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cystitis fibrosis

Cheng-Huang Shen, Shou-Chieh Wang, Shou-Tsung Wang, Shu-Mei Lin, Jiann-Der Wu, Chang-Te Lin, Yi-Wen Liu
Long-term ketamine abuse has been shown to affect the lower urinary tract and result in interstitial cystitis-like syndrome. However, the causative mechanism of ketamine-induced dysfunction remains unclear. The present study aimed to investigate the physiological, histological and molecular changes on ketamine‑associated cystitis (KC) in a mouse model. Both male and female Balb/c mice were separately distributed into the control group (normal saline) and ketamine group, which received ketamine hydrochloride (100 mg/kg/day) daily by intraperitoneal injection for a total period of 20 weeks...
September 2016: Molecular Medicine Reports
Youssef H Zeidan, Nan Xiao, Hongbin Cao, Christina Kong, Quynh-Thu Le, Davud Sirjani
PURPOSE: Xerostomia is a common radiation sequela, which has a negative impact on the quality of life of patients with head and neck cancer. Current treatment strategies offer only partial relief. Botulinum toxins (BTX) have been successfully used in treating a variety of radiation sequelae such as cystitis, proctitis, fibrosis, and facial pain. The purpose of this study was to evaluate the effect of BTX on radiation-induced salivary gland damage. METHODS AND MATERIALS: We used a previously established model for murine salivary gland irradiation (IR)...
April 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Thais Figueiredo Palma, Márcia Lanzoni de Alvarenga, Amedea Barozzi Seabra, Marcelo Ganzarolli de Oliveira, Cássio Luis Zanettini Riccetto
OBJECTIVE: The aim of this study was to develop an experimental model of inducing interstitial cystitis through intravesical instillation of a polymeric solution containing the NO donor S-nitrousglutathione (GSNO) and to compare it to the experimental interstitial cystitis induced by vesical instillation of protamine and potassium chloride. METHODS: A total of 40 female Wistar rats were used and divided into four groups: 1 - ten rats treated with saline solution + GSNO; 2 - ten rats treated with saline solution + polymeric solution (without GNSO); 3 - ten rats treated with protamine sulphate + KCl; 4 - ten rats treated with protamine sulphate + GSNO...
September 2010: Einstein
A Kocot, H Riedmiller
BACKGROUND: Radiotherapy plays a substantial role in the treatment of malignancies. The side effects and long-term sequelae of radiotherapy are manifold and depend on the single doses and the total dosage, the time interval between two doses, the size of the irradiated tissue area and the radiation sensitivity of individual tissues. The urological complications following radiotherapy include inflammatory alterations of the bladder (radiation-induced hemorrhagic cystitis), fibrosis with subsequent radiogenic shrunken bladder, stenosis of the ureter and formation of secondary retroperitoneal fibrosis...
December 2015: Der Urologe. Ausg. A
Urszula Zaleska-Dorobisz, Anna Biel, Dąbrówka Sokołowska-Dąbek, Cyprian Olchowy, Mateusz Łasecki
OBJECTIVE: The aim of this study was to evaluate the usefulness of ultrasonography in the diagnosis of hemorrhagic cystitis following bone marrow transplantation in children. MATERIAL AND METHODS: The study involved an analysis of clinical material and the results of imaging tests performed in 334 patients who underwent hematopoietic cell transplantation. Ultrasonographic findings in 42 patients with hemorrhagic cystitis were analyzed in detail. The ultrasound images served to assess the severity of hemorrhagic cystitis and the results were compared with the clinical assessment of the disease on the Droller scale, as well as the laboratory and endoscopic tests...
September 2014: Journal of Ultrasonography
Brian Becknell, Ahmad Z Mohamed, Birong Li, Michael E Wilhide, Susan E Ingraham
PURPOSE: Urinary stasis is a risk factor for recurrent urinary tract infection (UTI). Homozygous mutant Megabladder (Mgb-/-) mice exhibit incomplete bladder emptying as a consequence of congenital detrusor aplasia. We hypothesize that this predisposes Mgb-/- mice to spontaneous and experimental UTI. METHODS: Mgb-/-, Mgb+/-, and wild-type female mice underwent serial ultrasound and urine cultures at 4, 6, and 8 weeks to detect spontaneous UTI. Urine bacterial isolates were analyzed by Gram stain and speciated...
2015: PloS One
N M Dreger, S Degener, S Roth, A S Brandt, D A Lazica
BACKGROUND: Urethral pain syndrome is a symptom complex including dysuria, urinary urgency and frequency, nocturia and persistent or intermittent urethral and/or pelvic pain in the absence of proven infection. These symptoms overlap with several other conditions, such as interstitial cystitis bladder pain syndrome and overactive bladder. Urethral pain syndrome may occur in men but is more frequent in women. DIAGNOSTIC: The exact etiology is unknown but infectious and psychogenic factors, urethral spasms, early interstitial cystitis, hypoestrogenism, squamous metaplasia as well as gynecological risk factors are discussed...
September 2015: Der Urologe. Ausg. A
Miho Song, Hwan Yeul Yu, Ji-Youn Chun, Dong-Myung Shin, Soo Hyun Song, Myung-Soo Choo, Yun Seob Song
Ketamine abusers have greatly increased in number worldwide during recent years. The consumption of ketamine has increased, as have the number of published accounts of devastating urological sequelae. However, the mechanism of ketamine-associated urinary tract dysfunction remains unclear. This study was to evaluate the ketamine dose-dependency of ketamine-induced cystitis (KC) in a rat model. A total of 42 Sprague-Dawley rats (female, 10-week-old) were used. Each of the 7 KC rat models were induced by 1, 5, 10, 25 and 50 mg/kg ketamine intravenous injection for two weeks...
2016: Drug and Chemical Toxicology
Keh-Min Liu, Shu-Mien Chuang, Cheng-Yu Long, Yi-Lun Lee, Chao-Chuan Wang, Mei-Chin Lu, Rong-Jyh Lin, Jian-He Lu, Mei-Yu Jang, Wen-Jeng Wu, Wan-Ting Ho, Yung-Shun Juan
Ketamine abusers develop severe lower urinary tract symptoms. The major aims of the present study were to elucidate ketamine-induced ulcerative cystitis and bladder apoptosis in association with oxidative stress mediated by mitochondria and the endoplasmic reticulum (ER). Sprague-Dawley rats were distributed into three different groups, which received normal saline or ketamine for a period of 14 or 28 days, respectively. Double-labeled immunofluorescence experiments were performed to investigate tight junction proteins for urothelial barrier functions...
August 15, 2015: American Journal of Physiology. Renal Physiology
Miao Zhang, Shu-Kun Jiang, Zhi-Ling Tian, Meng Wang, Rui Zhao, Lin-Lin Wang, Shan-Shan Li, Min Liu, Jiao-Yong Li, Meng-Zhou Zhang, Da-Wei Guan
Skeletal muscle injuries repair typically is an overlapping event between inflammation and tissue repair. Our previous study has demonstrated that activation of cannabinoid receptor type 2 (CB2R) by JWH-133 alleviates fibrosis in the repair of rat skeletal muscle contusion. Meanwhile, accumulated data show that CB2R stimulation exerts anti-inflammatory property in sepsis and cystitis. However, the effects of CB2R on inflammatory cytokines in response to the repair of skeletal muscle contusion are still unknown...
2015: International Journal of Clinical and Experimental Pathology
Yung-Shun Juan, Yi-Lun Lee, Cheng-Yu Long, Jhen-Hong Wong, Mei-Yu Jang, Jian-He Lu, Wen-Jeng Wu, Yen-Shun Huang, Wei-Chiao Chang, Shu-Mien Chuang
The number of ketamine abusers has increased significantly recently. Ketamine abusers exhibit urinary frequency, urgency, and at times urinary incontinence. Our aim was to investigate the role of transcription factor NF-κB and cyclooxygenase (COX)-2 in ketamine-induced cystitis. Sprague-Dawley rats were distributed into three groups, which received saline or treatment with ketamine or ketamine combined with a Cox-2 inhibitor (parecoxib). In addition, the toxic effect of ketamine and its metabolites were examined by primary urothelial cell culture...
August 2015: American Journal of Pathology
Anna Brzozowska, Magdalena Idziak, Franciszek Burdan, Maria Mazurkiewicz
Radiotherapy is one of the main methods of cancer treatment alone or in combination with chemotherapy. It is applied in about 60% of oncological patients. However, in spite of its clinical usefulness, radiotherapy is associated with a high risk of radiation-induced side effects, including dermatitis, enteritis, cystitis, pericarditis, pneumonia or depression, sexual function disorders, cardiomiopathy, coronary heart disease, anomalies of heart valves and development of second malignant tumor. The early diagnosis and proper treatment of radiation-induced side effects have a major impact on patients` quality of life and future prognosis...
May 2015: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
E V Kul'chavenia, D P Kholtobin
A comparative analysis of cystoscopic and pathologic patterns in 190 patients hospitalized for differential diagnosis or treatment of genitourinary tuberculosis in 2008-2011 was performed. All patients underwent polyfocal biopsy followed by pathologic examination of biopsy specimens. Furthermore, a comparison of results ofpathomorphological studies of tissue obtained by biopsy and after cystectomy was conducted. Cystoscopy in all patients with tuberculosis of the bladder (TB) revealed the reduced bladder capacity in contrast to patients with other urological diseases...
November 2014: Urologii︠a︡
Yi Song Lv, You Sheng Yao, Lu Rong, Ming En Lin, Bi Hua Deng, Yun Xie, Hai Huang, Tian Xin Lin, Ke Wei Xu, Jian Huang
OBJECTIVES: To determine whether a potential rat model of bladder pain syndrome could be developed through long-term intermittent intravesical hyaluronidase. METHODS: A total of 64 female Sprague-Dawley rats were divided into a control group, a low-dose hyaluronidase (1 mg/mL) group, a high-dose hyaluronidase (4 mg/mL) group and a hyaluronic acid-treated group. Hyaluronidase was given intravesically three times a week for 1 month. Hyaluronic acid (0.5 mL, 0.8 mg/mL) was introduced intravesically to hyaluronidase-treated rats' bladders...
June 2014: International Journal of Urology: Official Journal of the Japanese Urological Association
Geoffrey Burnstock
Purinergic signalling is involved in a number of physiological and pathophysiological activities in the lower urinary tract. In the bladder of laboratory animals there is parasympathetic excitatory cotransmission with the purinergic and cholinergic components being approximately equal, acting via P2X1 and muscarinic receptors, respectively. Purinergic mechanosensory transduction occurs where ATP, released from urothelial cells during distension of bladder and ureter, acts on P2X3 and P2X2/3 receptors on suburothelial sensory nerves to initiate the voiding reflex, via low threshold fibres, and nociception, via high threshold fibres...
March 2014: Purinergic Signalling
Raul Ordorica, Lucas R Wiegand, J Christopher Webster, Jorge L Lockhart
PURPOSE: Ureteral loss represents a surgical challenge to provide low pressure drainage while avoiding urinary stasis and reflux. The ideal replacement should optimize drainage while minimizing absorption, allowing for ureteral repair of varied lengths and locations with maximal preservation of the urinary tract. We reviewed our experience with ureteral repair, focusing on the use of reconfigured intestine. We report what is to our knowledge the novel use of reconfigured intestine as an onlay flap on the preserved ureteral segment and as a circumferential interpositioned segment...
May 2014: Journal of Urology
Woong-Jin Bae, U-Syn Ha, Seol Kim, Su-Jin Kim, Sung-Hoo Hong, Ji-Youl Lee, Tae-Kon Hwang, Sung-Yeoun Hwang, Hong-Jun Kim, Sae-Woong Kim
AIMS: We investigated the effect of the multi-herbal medicine, WSY-1075 in an animal model of hydrochloric acid (HCl)-induced cystitis. METHODS: Rats were randomly assigned to three groups: sham-operated (control), HCl-induced only (HC), and HC treated with WSY-1075 (HC + WT). Oral administration of either distilled water (control, HC) or WSY-1075 (400 mg/kg) was continued for 4 weeks. In HC and HC + WT groups, cystitis was induced with 0.4 M HCl beginning on the 22nd day...
January 2015: Neurourology and Urodynamics
Jin Kyu Oh, Khae-Hawn Kim
A 50-year-old female who had undergone laparoscopic total hysterectomy at a local clinic owing to leiomyoma of the uterus was referred to our hospital after having dysuria, urgency, frequency, lower abdominal pain and right flank pain over several months. After routine examinations, cystoscopy, computed tomography and magnetic resonance imaging were performed, and non-ulcerative interstitial cystitis accompanied by postoperative fibrosis secondary to a previous surgery was suggested. Pentosan sulfuric polyester (Elmiron, Alza Pharmaceuticals, Mountain View, CA) reduced her severely debilitating symptoms and improved her quality of life...
May 2013: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Shu-Mien Chuang, Keh-Min Liu, Yi-Lun Li, Mei-Yu Jang, Hei-Hwa Lee, Wen-Jeng Wu, Wei-Chiao Chang, Robert M Levin, Yung-Shun Juan
AIMS: The aims of the present study were to investigate voiding patterns, tissue constituents and the expressions of cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS) involved in ketamine-induced ulcerative cystitis in rat urinary bladder. METHODS: Thirty Sprague-Dawley rats were distributed into three groups which received saline or ketamine (25 mg/kg/day) for a period of 14 and 28 days. In each group, cystometry was performed weekly and the concentration of ketamine and its metabolites (norketamine) was assayed...
November 2013: Neurourology and Urodynamics
Haytham M Shebel, Khaled M Elsayes, Heba M Abou El Atta, Yehia M Elguindy, Tarek A El-Diasty
Genitourinary schistosomiasis is produced by Schistosoma haematobium, a species of fluke that is endemic to Africa and the Middle East, and causes substantial morbidity and mortality in those regions. It also may be seen elsewhere, as a result of travel or immigration. S haematobium, one of the five fluke species that account for most human cases of schistosomiasis, is the only species that infects the genitourinary system, where it may lead to a wide spectrum of clinical symptoms and signs. In the early stages, it primarily involves the bladder and ureters; later, the kidneys and genital organs are involved...
July 2012: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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