keyword
https://read.qxmd.com/read/38281923/hypertension-and-urologic-chronic-pelvic-pain-syndrome-an-analysis-of-mapp-i-data
#1
JOURNAL ARTICLE
Rosalynn R Z Conic, Terrie Vasilopoulos, Karthik Devulapally, Rene Przkora, Andrew Dubin, Kimberly T Sibille, Aaron D Mickle
BACKGROUND: Urologic chronic pelvic pain syndrome (UCPPS), which includes interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis (CP/CPPS), is associated with increased voiding frequency, nocturia, and chronic pelvic pain. The cause of these diseases is unknown and likely involves many different mechanisms. Dysregulated renin-angiotensin-aldosterone-system (RAAS) signaling is a potential pathologic mechanism for IC/BPS and CP/CPPS. Many angiotensin receptor downstream signaling factors, including oxidative stress, fibrosis, mast cell recruitment, and increased inflammatory mediators, are present in the bladders of IC/BPS patients and prostates of CP/CPPS patients...
January 28, 2024: BMC Urology
https://read.qxmd.com/read/38177637/progressive-alteration-of-murine-bladder-elasticity-in-actinic-cystitis-detected-by-brillouin-microscopy
#2
JOURNAL ARTICLE
Laura Martinez-Vidal, Claudia Testi, Emanuele Pontecorvo, Filippo Pederzoli, Elisa Alchera, Irene Locatelli, Chiara Venegoni, Antonello Spinelli, Roberta Lucianò, Andrea Salonia, Alessandro Podestà, Giancarlo Ruocco, Massimo Alfano
Bladder mechanical properties are critical for organ function and tissue homeostasis. Therefore, alterations of tissue mechanics are linked to disease onset and progression. This study aims to characterize the tissue elasticity of the murine bladder wall considering its different anatomical components, both in healthy conditions and in actinic cystitis, a state characterized by tissue fibrosis. Here, we exploit Brillouin microscopy, an emerging technique in the mechanobiology field that allows mapping tissue mechanics at the microscale, in non-contact mode and free of labeling...
January 4, 2024: Scientific Reports
https://read.qxmd.com/read/38172343/pan-cancer-analyses-of-the-associations-between-109-pre-existing-conditions-and-cancer-treatment-patterns-across-19-adult-cancers
#3
JOURNAL ARTICLE
Wai Hoong Chang, Alvina G Lai
Comorbidities present considerable challenges to cancer treatment and care. However, little is known about the effect of comorbidity on cancer treatment decisions across a wide range of cancer types and treatment modalities. Harnessing a cohort of 280,543 patients spanning 19 site-specific cancers, we explored pan-cancer frequencies of 109 comorbidities. Multinomial logistic regression was used to analyse the relationship between comorbidities and cancer treatment types, while binomial logistic regression examined the association between comorbidities and chemotherapy drug types, adjusting for demographic and clinical factors...
January 3, 2024: Scientific Reports
https://read.qxmd.com/read/38055393/emodin-inhibits-bladder-inflammation-and-fibrosis-in-mice-with-interstitial-cystitis-by-regulating-jmjd3
#4
JOURNAL ARTICLE
Junyu Lai, Xing Liu, Hongwei Su, Yongsheng Zhu, Ke Xin, Mingwei Huang, Songtao Luo, Hai Tang
PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a devastating urological chronic pelvic pain condition. In search of a potential treatment, we investigated the effect of emodin on IC/BPS inflammation and fibrosis, and explore the potential mechanism. METHODS: An experimental model of interstitial cystitis was induced by cyclophosphamide, and human bladder smooth muscle cells were treated with lipopolysaccharide to establish the cell model in vitro...
2023: Acta Cirúrgica Brasileira
https://read.qxmd.com/read/37931000/tgf-%C3%AE-inhibitor-treatment-of-h%C3%A2-o%C3%A2-induced-cystitis-models-provides-biochemical-mechanism-for-elucidating-interstitial-cystitis-painful-bladder-syndrome-patients
#5
JOURNAL ARTICLE
Hideto Taga, Tsunao Kishida, Yuta Inoue, Kenta Yamamoto, Shin-Ichiro Kotani, Tsujimoto Masashi, Osamu Ukimura, Osam Mazda
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic disease for which no effective treatment is available. Transforming growth factor-β (TGF-β) is thought to be involved in the pathogenesis of IC/PBS, and previous studies have suggested that administrations of a TGF-β inhibitor significantly ameliorated IC/PBS in a mouse model. However, the molecular mechanisms underlying the therapeutic effect of a TGF-b inhibitor on IC/PBS has not been comprehensively analyzed. TGF-β has a variety of actions, such as regulation of immune cells and fibrosis...
2023: PloS One
https://read.qxmd.com/read/37668867/effects-of-low-intensity-extracorporeal-shock-wave-therapy-on-lipopolysaccharide-cystitis-in-a-rat-model-of-interstitial-cystitis-bladder-pain-syndrome
#6
JOURNAL ARTICLE
Naohisa Kusakabe, Tadanobu Chuyo Kamijo, Naoki Wada, Hiroki Chiba, Nobuo Shinohara, Minoru Miyazato
PURPOSE: To investigate the effect of low-intensity extracorporeal shock wave therapy (LiESWT) on lipopolysaccharide (LPS)-induced cystitis in an animal model of interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: Sprague-Dawley rats were divided into three groups: control, cystitis (LPS group, intravesical injection of LPS (1 mg) twice), and cystitis with LiESWT (LiESWT group). On the third and fourth days, LiESWT was administered (0.12 mJ/mm2 , 300 shots each time) on the lower abdomen toward the bladder...
September 5, 2023: International Urology and Nephrology
https://read.qxmd.com/read/37589872/eosinophilic-cystitis-a-case-report-of-a-pseudotumoral-lesion
#7
REVIEW
Mirco Cleva, Bruschi Ennio, Bruschi Ferdinando, Valentino Massimo
Eosinophilic cystitis is a rare inflammatory disorder of the bladder, characterized by eosinophilic infiltration of the bladder wall, fibrosis of the mucosa, and muscle necrosis. Ultrasonography, when performed, shows a pseudotumoral mass that can be mistaken for malignancy. We report a case of a woman referred to our department in which an ultrasound showed a bladder mass and the biopsy demonstrated the presence of eosinophilic cystitis. The patient was treated with medical treatment and the outcome was favorable with the disappearance of symptoms and no recurrence at controls...
December 2023: Journal of Ultrasound
https://read.qxmd.com/read/37545795/pathophysiology-clinical-presentation-and-management-of-ketamine-induced-cystitis
#8
JOURNAL ARTICLE
Jia-Fong Jhang, Lori A Birder, Hann-Chorng Kuo
Ketamine is illegally used as a recreational drug in many Asian countries. Long-term ketamine abusers often develop irritable bladder symptoms that gradually develop into more severe urinary frequency and urgency and eventually into a painful ulcerated bladder. These patients typically have reduced functional bladder capacity, increased bladder sensation, detrusor overactivity, severe urgency, urinary incontinence, and bladder contracture. Ketamine metabolites can cause severe inflammation of the urothelium, urothelial barrier deficits, vascular endothelial fibrinoid changes, increased oxidative stress, and bladder wall fibrosis...
2023: Tzu chi medical journal
https://read.qxmd.com/read/37501638/haemorrhagic-cystitis-a-review-of-management-strategies-and-emerging-treatments
#9
REVIEW
Kevin D Li, Charles P Jones, Nizar Hakam, Bradley A Erickson, Alex J Vanni, Michael B Chancellor, Benjamin N Breyer
Haemorrhagic cystitis (HC) is characterised by persistent haematuria and lower urinary tract symptoms following radiotherapy or chemotherapy. Its pathogenesis is poorly understood but thought to be related to acrolein toxicity following chemotherapy or fibrosis/vascular remodelling after radiotherapy. There is no standard of care for patients with HC, although existing strategies including fulguration, hyperbaric oxygen therapy, botulinum toxin A, and other intravesical therapies have demonstrated short-term efficacy in cohort studies...
July 28, 2023: BJU International
https://read.qxmd.com/read/37221266/therapeutic-effects-of-axitinib-an-anti-angiogenic-tyrosine-kinase-inhibitor-on-interstitial-cystitis
#10
JOURNAL ARTICLE
Jung Hyun Shin, Chae-Min Ryu, Hwan Yeul Yu, Yang Soon Park, Dong-Myung Shin, Myung-Soo Choo
To investigate the therapeutic effects of axitinib, a tyrosine kinase inhibitor, in an interstitial cystitis (IC) rat model. IC patients with or without Hunner lesion and non-IC controls were enrolled (n = 5/group). Bladder tissues were stained with vascular endothelial growth factor (VEGF), VEGF receptor 2 (VEGFR-2), platelet-derived growth factor (PDGF), and PDGF receptor B (PDGFR-B). The IC group showed extensive VEGFR-2 and PDGFR-B staining compared with controls. Next, ten-week-old female Sprague Dawley rats were divided into three groups (n = 10/group): sham, hydrochloride (HCl), and axitinib groups...
May 23, 2023: Scientific Reports
https://read.qxmd.com/read/37091883/immobilizing-interstitial-cardiac-fibrosis
#11
JOURNAL ARTICLE
Yuriy L Shevchenko, Alexey V Plotnitsky, Daniil S Ulbashev
BACKGROUND: The alterations in the endomysium and perimysium might cause compaction and gradual mechanical compression of cardiomyocytes resulting in their immobilization. This process finally leads to severe stiffening, so that the newly formed frame around individual cardiomyocytes and their clusters hinders normal diastole, and later systole. This phenomenon is referred to as immobilizing interstitial cardiac fibrosis (IICF). Deciphering the molecular and structural elements of myocardial changes is the key to understanding the pathogenetic foundations of heart failure development...
April 2023: Cardiology Research
https://read.qxmd.com/read/36914420/tropisetron-ameliorated-cyclophosphamide-induced-hemorrhagic-cystitis-via-restraining-tlr-4-nf-%C3%AE%C2%BAb-and-jak1-stat3-signaling-pathways
#12
JOURNAL ARTICLE
Li Guo, Chen Ma, Meiyu Wang, Yuefeng Du
OBJECTIVE: The main pathological changes of hemorrhagic cystitis (HC) are bladder inflammation, bladder epithelial damage and mast cell infiltration. Tropisetron has been corroborate to conduct a protective role in HC, but its specific etiology remains unclear. The objective of this research was to estimate the mechanism of action of Tropisetron in haemorrhagic cystitis tissue. METHODS: Cyclophosphamide (CTX) was utilized to induce the construction of HC rat model, and rats were handled with different doses of Tropisetron...
February 2023: Archivos Españoles de Urología
https://read.qxmd.com/read/36600004/the-efficacy-and-safety-of-a-human-perirenal-adipose-tissue-derived-stromal-vascular-fraction-in-an-interstitial-cystitis-rat-model
#13
JOURNAL ARTICLE
Ji Yong Ha, Eun Hye Lee, So Young Chun, Jun Nyung Lee, Yun-Sok Ha, Jae-Wook Chung, Bo Hyun Yoon, Minji Jeon, Hyun Tae Kim, Tae Gyun Kwon, Eun Sang Yoo, Bum Soo Kim
BACKGROUND: Interstitial cystitis (IC) is a chronic and intractable disease that can severely deteriorate patients' quality of life. Recently, stem cell therapy has been introduced as a promising alternative treatment for IC in animal models. We aimed to verify the efficacy and safety of the human perirenal adipose tissue-derived stromal vascular fraction (SVF) in an IC rat model. METHODS: From eight-week-old female rats, an IC rat model was established by subcutaneous injection of 200 μg of uroplakin3A...
January 4, 2023: Tissue Engineering and Regenerative Medicine
https://read.qxmd.com/read/36498919/broaden-horizons-the-advancement-of-interstitial-cystitis-bladder-pain-syndrome
#14
REVIEW
Jin Li, Xianyanling Yi, Jianzhong Ai
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease that induces mental stress, lower urinary symptoms, and pelvic pain, therefore resulting in a decline in quality of life. The present diagnoses and treatments still lead to unsatisfactory outcomes, and novel diagnostic and therapeutic modalities are needed. Although our understanding of the etiology and pathophysiology of IC/BPS is growing, the altered permeability of the impaired urothelium, the sensitized nerves on the bladder wall, and the chronic or intermittent sensory pain with inaccurate location, as well as pathologic angiogenesis, fibrosis, and Hunner lesions, all act as barriers to better diagnoses and treatments...
November 23, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36362848/dehydrated-human-amnion-chorion-membrane-extracts-can-ameliorate-interstitial-cystitis-in-rats-by-down-regulating-inflammatory-cytokines-and-protein-coding-genes-a-preclinical-study
#15
JOURNAL ARTICLE
Che-Hsueh Yang, Min-Che Tung, Yi-Sheng Lin, Chao-Yu Hsu, Ivan Akhrymuk, Kok-Tong Tan, Yen-Chuan Ou, Chi-Chien Lin
The study aimed to investigate the therapeutic impact of intravesical instillation of dehydrated human amnion-chorion membrane (HACM) extracts based on the primary pathological feature of interstitial cystitis (IC). We divided 15 female Sprague-Dawley rats into three groups: sham control, IC, and treatment group. IC was induced by 400-µL lipopolysaccharide (1 µg/µL), and it was replaced with normal saline in the sham control group. After IC induction, 300 µL dehydrated HACM extracts (3 mg/kg) were instilled into rats' urinary bladder weekly for 3 weeks...
October 25, 2022: Life
https://read.qxmd.com/read/36208109/intravesical-ir-780-instillation-prevents-radiation-cystitis-by-protecting-urothelial-integrity
#16
JOURNAL ARTICLE
Jinjin Li, Chongxing Shen, Heping Qiu, Jianwu Wang, Xiaofeng Yue, Linyong Dai, Yuandi Huang, Tong Li, Qiang Fang, Yi Zhi, Chunmeng Shi, Weibing Li
PURPOSE: To explore an efficient preventive strategy for radiation cystitis. METHODS: We instilled IR-780 into the bladders of rats 1 h before bladder irradiation, and its bio-distribution was observed at different times. Bladders were then examined for pathogenic alterations and inflammation levels by day 3 and week 12 postirradiation, and the functional characteristics of the bladder were tested via cystometry by week 12. Human uroepithelial sv-huc-1 cells were used to determine the effect of IR-780 on cell viability, regardless of irradiation...
October 8, 2022: Neurourology and Urodynamics
https://read.qxmd.com/read/36160201/chicken-igy-reduces-the-risk-of-pseudomonas-aeruginosa-urinary-tract-infections-in-a-murine-model
#17
JOURNAL ARTICLE
Franziska A Schwartz, Lars Christophersen, Kim Thomsen, Sarah Baekdal, Maria Pals Bendixen, Mette Jørgensen, Ida Kirstine Bull Rasmussen, Anne Sofie Laulund, Niels Høiby, Claus Moser
Introduction: Urinary tract infections (UTIs) with Pseudomonas aeruginosa are a severe problem in disposed patients in modern healthcare. Pseudomonas aeruginosa establishes recalcitrant biofilm infections and can develop antibiotic resistance. Gargling with avian egg yolk anti- Pseudomonas antibodies (IgY) has shown clinical effect in preventing onset of chronic P. aeruginosa lung infections in patients with cystic fibrosis (CF). Therefore, we speculated whether passive intravesically administered IgY immunotherapy could be a novel strategy against P...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/36101361/two-new-potential-therapeutic-approaches-in-radiation-cystitis-derived-from-mesenchymal-stem-cells-extracellular-vesicles-and-conditioned-medium
#18
JOURNAL ARTICLE
Carole Helissey, Nathalie Guitard, Hélène Théry, Sylvie Goulinet, Philippe Mauduit, Maria Girleanu, Anne-Laure Favier, Michel Drouet, Charles Parnot, Cyrus Chargari, Sophie Cavallero, Sabine François
Background: Radiation cystitis (RC) results from chronic inflammation, fibrosis, and vascular damage. The urinary symptoms it causes have a serious impact on patients' quality of life. Despite the improvement in irradiation techniques, the incidence of radiation cystitis remains stable over time, and the therapeutic possibilities remain limited. Mesenchymal stem/stromal cells (MSC) appear to offer2 a promising therapeutic approach by promoting tissue repair through their paracrine action via extracellular vesicles (MSC-EVs) or conditioned medium from human mesenchymal stromal cells (MSC-CM)...
June 28, 2022: Biology
https://read.qxmd.com/read/36076544/cultured-versus-freshly-isolated-adipose-derived-stem-cells-in-improvement-of-the-histopathological-outcomes-in-hcl-induced-cystitis-in-a-rat-model
#19
JOURNAL ARTICLE
Hanan Hendawy, Elsayed Metwally, Ahmed Elfadadny, Tomohiko Yoshida, Danfu Ma, Kazumi Shimada, Lina Hamabe, Kenta Sasaki, Ryou Tanaka
Interstitial cystitis (IC) is an incurable chronic disease. The etiology of IC is unclear, and no effective therapies have been established. Here, using a hydrogen chloride (HCL)-induced IC in a rat model, the therapeutic potency of stromal vascular fraction (SVF) and Adipose-derived stem cells (ADSCs) was studied. Thirty-six female Sprague Dawley rats were divided into four groups: the sham, HCL, (HCL+SVF) group, and (HCL+ADSCs) group (9 for each). Cystitis was induced by transurethral instillation of HCL, while PBS was used for the sham group...
September 2022: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/35812545/pelvic-irradiation-a-rare-cause-of-concomitant-radiation-cystitis-and-uretero-iliac-artery-fistula-causing-gross-hematuria-and-hemorrhagic-shock
#20
Maleeha Saleem, Karan H Pahuja, Alex Arnouk
Uretero-iliac artery fistulas (UIAFs) are a rare cause of gross hematuria. They form as a result of poorly vascularized uretero-iliac adhesions and the resultant fibrosis and chronic inflammatory changes. Causes include previous pelvic surgery, radiotherapy, and chronic ureteral stenting. The presentation is usually intermittent massive gross hematuria with acute anemia and hemorrhagic shock. A high index of suspicion is warranted in patients with predisposing factors for prompt diagnosis and management as it may be associated with life-threatening hemorrhage...
June 2022: Curēus
keyword
keyword
99043
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.