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https://www.readbyqxmd.com/read/27829880/immunosuppression-therapy-in-the-management-of-peripartum-cardiomyopathy-a-case-series-and-literature-review
#1
Joyee Basu, Christopher Redman, Oliver Ormerod
Peripartum cardiomyopathy is a heart failure syndrome occurring late in pregnancy or during the early post-natal period. The pathophysiology of peripartum cardiomyopathy is not fully understood and various mechanisms have been postulated including an underlying inflammatory process. We here report four cases presenting with acute left ventricular systolic dysfunction. Three out of four of the patients presented with a left ventricular ejection fraction <30% and one with a left ventricular ejection fraction of 35%...
December 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27790717/in-utero-coxsackievirus-b4-infection-of-the-mouse-thymus
#2
Hela Jaïdane, Aymen Halouani, Habib Jmii, Firas Elmastour, Saïda Abdelkefi, Gwennaëlle Bodart, Hélène Michaux, Tahar Chakroun, Famara Sane, Moncef Mokni, Vincent Geenen, Didier Hober, Mahjoub Aouni
Type B Coxsackievirus (CV-B) infections are frequently involved in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes, encephalitis, thyroiditis, or Sjögren's syndrome. Serological and virological evidence suggests that maternal infections during pregnancy can play a role in the appearance of these diseases in offspring. The current study aims to explore the effect of an in utero CV-B infection on the fetal thymus, the central site for programming immunological self-tolerance...
October 28, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27742423/reproductive-history-of-women-with-takotsubo-cardiomyopathy
#3
Elena Salmoirago-Blotcher, Shira Dunsiger, Heather H Swales, Gerard P Aurigemma, Ira Ockene, Lindsey Rosman, Ilan S Wittstein
Takotsubo cardiomyopathy (TC) occurs predominantly in postmenopausal women, suggesting a possible role of reproductive and hormonal factors in the pathophysiology of this condition. Yet reproductive characteristics of women with TC have received limited attention. This prospective case-control study sought to explore reproductive characteristics associated with TC. Incident TC cases and myocardial infarction (MI) controls were recruited among consecutive women presenting at the emergency departments of 2 large medical centers in Massachusetts and Connecticut...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27285199/women-s-experiences-being-diagnosed-with-peripartum-cardiomyopathy-a-qualitative-study
#4
Rebecca L Dekker, Christine H Morton, Paula Singleton, Audrey Lyndon
INTRODUCTION: Cardiovascular disease has been identified as the leading cause of maternal mortality in the United States, with cardiomyopathy, including peripartum cardiomyopathy (PPCM), accounting for 12% to 16% of all pregnancy-related deaths. The purpose of this study was to describe women's experiences being diagnosed with PPCM. METHODS: This investigation was conducted using a qualitative design. We collected publicly available narratives posted by 92 women with PPCM (mean [SD] age 29 [6] years, mean [SD] ejection fraction 25...
July 2016: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/26970832/relaxin-2-and-soluble-flt1-levels-in-peripartum-cardiomyopathy-results-of-the-multicenter-ipac-study
#5
Julie Damp, Michael M Givertz, Marc Semigran, Rami Alharethi, Gregory Ewald, G Michael Felker, Biykem Bozkurt, John Boehmer, Jennifer Haythe, Hal Skopicki, Karen Hanley-Yanez, Jessica Pisarcik, Indrani Halder, John Gorcsan, Sarosh Rana, Zoltan Arany, James D Fett, Dennis M McNamara
OBJECTIVES: This study explored the association of vascular hormones with myocardial recovery and clinical outcomes in peripartum cardiomyopathy (PPCM). BACKGROUND: PPCM is an uncommon disorder with unknown etiology. Angiogenic imbalance may contribute to its pathophysiology. METHODS: In 98 women with newly diagnosed PPCM enrolled in the Investigation in Pregnancy Associated Cardiomyopathy study, serum was obtained at baseline for analysis of relaxin-2, prolactin, soluble fms-like tyrosine kinase 1 (sFlt1), and vascular endothelial growth factor (VEGF)...
May 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/26875582/-the-clinical-characteristics-and-prognosis-of-patients-with-peripartum-cardiomyopathy
#6
Xiaoxiao Guo, Yongtai Liu, Ligang Fang, Quan Fang
OBJECTIVE: To explore the clinical characteristics and risk factors in patients with peripartum cardiomyopathy (PPCM). METHODS: A total of 35 patients admitted in Peking Union Medical College Hospital and diagnosed with PPCM between January 1995 and December 2014 was included and analyzed in this study. The subjects were divided into two groups: the early recovery and delayed recovery. Early recovery was defined as normalization of left ventricle ejection fraction (LVEF) ≥50% before 6 months post-diagnosis...
February 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/26515744/symptoms-in-women-with-peripartum-cardiomyopathy-a-mixed-method-study
#7
Harshida Patel, Marie Berg, Anders Barasa, Cecily Begley, Maria Schaufelberger
OBJECTIVE: Peripartum Cardiomyopathy is a form of cardiac disease often associated with cardiac failure, occurring in late pregnancy or after childbirth. The anatomical and physiological changes in the mother associated with normal pregnancy are profound, and this may result in symptoms and signs that overlap with Peripartum Cardiomyopathy, leading to missed or delayed diagnosis. Women's experiences of Peripartum Cardiomyopathy symptoms remain poorly studied. The aim of this study was to explore and describe women's experiences of symptoms in Peripartum Cardiomyopathy...
January 2016: Midwifery
https://www.readbyqxmd.com/read/26474841/current-knowledge-and-recent-development-on-management-of-peripartum-cardiomyopathy
#8
Nadia Bouabdallaoui, Frederic Mouquet, Guillaume Lebreton, Pierre Demondion, Thierry H Le Jemtel, Pierre V Ennezat
Heart failure with left ventricular dysfunction occurring during pregnancy or during the post-partum period in patients without history of cardiovascular disease defines peripartum cardiomyopathy (PPCM). PPCM carries a high morbidity and mortality rate as well as the possibility of recovery ad integrum. Its incidence shows ethnic variations, with a greater prevalence of the disease among women with African descent. Pathogenesis of PPCM remains poorly understood. Both "oxidative stress-prolactin axis" and "anti-angiogenic-signaling excess" hypotheses are currently being investigated...
October 16, 2015: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/26293760/clinical-outcomes-for-peripartum-cardiomyopathy-in-north-america-results-of-the-ipac-study-investigations-of-pregnancy-associated-cardiomyopathy
#9
MULTICENTER STUDY
Dennis M McNamara, Uri Elkayam, Rami Alharethi, Julie Damp, Eileen Hsich, Gregory Ewald, Kalgi Modi, Jeffrey D Alexis, Gautam V Ramani, Marc J Semigran, Jennifer Haythe, David W Markham, Josef Marek, John Gorcsan, Wen-Chi Wu, Yan Lin, Indrani Halder, Jessica Pisarcik, Leslie T Cooper, James D Fett
BACKGROUND: Peripartum cardiomyopathy (PPCM) remains a major cause of maternal morbidity and mortality. OBJECTIVES: This study sought to prospectively evaluate recovery of the left ventricular ejection fraction (LVEF) and clinical outcomes in the multicenter IPAC (Investigations of Pregnancy Associated Cardiomyopathy) study. METHODS: We enrolled and followed 100 women with PPCM through 1 year post-partum. The LVEF was assessed by echocardiography at baseline and at 2, 6, and 12 months post-partum...
August 25, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/26105465/pp144-profile-of-lupus-pregnancy-in-internal-medecine-practice
#10
T Haddad, D Hakem, A Berrah
INTRODUCTION: The pregnancies in systemic erythematous lupus (SLE) disease is a situation of high risk and involve both the mother and the fetus. The prematurity and the miscarriage are there more frequent, with increase risks of eclampsia, acute hypertension, HELP syndrome and of worsening renal disease. So the morbimortality is multiplied particularly when a anti-phospholipid syndrome 'APLS' is associated. The pregnancy remains however authorized when the SLE is in remission for more than 6 months with a validated treatment and successful means of monitoring...
July 2012: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25885847/anesthetic-management-for-caesarean-section-in-a-case-of-peripartum-cardiomyopathy
#11
Akanksha Dutt, Akshi Agarwal, Rama Chatterji, Farid Ahmed
Peripartum cardiomyopathy (PPCM) is a disease of unknown etiology which affects pregnant females during late pregnancy or during the first 5 months post-partum. The clinical presentation of these patients is similar to that of patients with dilated cardiomyopathy. Anesthetic management of such cases poses a challenge; due to the increased risk of various perioperative complications. We report the successful anesthetic management of lower segment caesarean section in a patient with PPCM.
May 2013: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/25495817/challenges-in-cardiology-research-in-pregnancy
#12
REVIEW
Tasneem Z Naqvi
Research in pregnancy is challenging as it involves a special 'vulnerable' group due to the involvement of the mother and the fetus. These challenges, which are inherent in studying pregnancy in physiologic and pathologic states, have contributed to the scant research in pregnancy. Until recently, most studies in pregnancy were nonrandomized and retrospective in nature, representing prevailing clinical standards of practice and clinicians' biases. Prospective studies were generally limited to single centers, comprising of small sample sizes and were observational in nature, rather than randomized studies involving therapy...
November 2014: Future Cardiology
https://www.readbyqxmd.com/read/25399800/why-do-some-recovered-peripartum-cardiomyopathy-mothers-experience-heart-failure-with-a-subsequent-pregnancy
#13
James D Fett, Tina P Shah, Dennis M McNamara
After concerns about survival and recovery from peripartum cardiomyopathy (PPCM), the question commonly asked is, "Is it safe to have another pregnancy?" While important advances have been made in the past decade in the recognition and treatment of PPCM, we still do not know why some apparently recovered PPCM mothers have a relapse of heart failure in a subsequent pregnancy. Knowing that some risk for relapse is always present, careful monitoring of the post-PPCM pregnancy is currently the best way to enable earlier diagnosis with institution of effective evidence-based treatment...
January 2015: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/25309691/a-pedunculated-left-ventricular-thrombus-in-a-women-with-peripartum-cardiomyopathy-evaluation-by-three-dimensional-echocardiography
#14
Rajiv Bharat Kharwar, Sharad Chandra, Sudhanshu Kumar Dwivedi, Ram Kirti Saran
Peripartum cardiomyopathy is a cardiac condition characterized by development of heart failure during the last month of pregnancy or during the first five months of post partum period without any other identifiable cause of heart failure. The hypercoagulable state in the pregnancy along with left ventricular (LV) systolic dysfunction predisposes the patient to thromboembolic complications like intraventricular thrombi. We report a case of a 30-year-old female with peripartum cardiomyopathy along with a highly mobile mass in the LV cavity on two dimensional echocardiography...
September 2014: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/25031933/pregnancy-in-a-patient-with-cancer-and-heart-failure-challenges-and-complexities
#15
Anecita P Fadol, Tara Lech, Courtney Bickford, Syed Wamique Yusuf
A 24-year-old African American female (L.R.) with a history of smoking and gestational diabetes was diagnosed with Hodgkin lymphoma. She received multiple chemotherapies, including six cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), followed by radiation therapy to left inguinal areas for a total of 30.6 Gy in 17 fractions; she obtained complete remission. Two years later, L.R. had disease relapse in the mediastinum and received two cycles of ESHAP (etoposide, methylprednisolone, high-dose cytarabine, cisplatin) followed by etoposide and ifosfamide...
March 2012: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/24888912/takotsubo-cardiomyopathy-after-cesarean-a-case-report-and-published-work-review-of-pregnancy-related-cases
#16
REVIEW
Miki Minatoguchi, Atsuo Itakura, Eiji Takagi, Manabu Nishibayashi, Mariko Kikuchi, Osamu Ishihara
Takotsubo cardiomyopathy (TCM) primarily affects postmenopausal women and is an important differential diagnosis of acute coronary syndrome. We describe a rare case of post-partum TCM, and present a published work review of the cases of pregnancy-associated TCM. A 24-year-old Japanese woman pregnant with twins suffered from premature membrane rupture at 31 gestational weeks. Following emergency cesarean delivery, she complained of sudden dyspnea. Transthoracic echocardiography revealed an inverted Takotsubo pattern (ejection fraction, 46%)...
June 2014: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/24754482/a-fatal-case-of-peripartum-cardiomyopathy
#17
Ronny Cohen, Thierry Mallet, Brooks Mirrer, Pablo Loarte, Michael Gale, Paul Kastell
Peripartum cardiomyopathy is a life-threatening cardiac condition affecting pregnant women either late in pregnancy or early in the post-partum period. The latest studies show a dramatic improvement in the mortality rates of women affected with this disorder, which has been correlated with advances in medical therapy for heart failure. However, patients continue to die of this condition. The following case report describes a typical patient with peripartum cardiomyopathy diagnosed on clinical grounds, along with echocardiogram findings of severe systolic dysfunction and global hypokinesis consistent with dilated cardiomyopathy...
June 2014: Acute Cardiac Care
https://www.readbyqxmd.com/read/24596396/pregnancy-in-women-with-an-implantable-cardioverter-defibrillator-is-it-safe
#18
Stéphane Boulé, Lionel Ovart, Christelle Marquié, Edward Botcherby, Didier Klug, Claude Kouakam, François Brigadeau, Laurence Guédon-Moreau, Ludivine Wissocque, Jonathan Meurice, Dominique Lacroix, Salem Kacet
AIMS: To describe obstetric/neonatal and cardiac outcomes for a cohort of women carrying implantable cardioverter-defibrillators (ICDs) during pregnancy. METHODS AND RESULTS: All women in routine follow-up at our institution for ICD implantation who became pregnant between 2006 and 2013 were included in this study. All ICDs were pre-pectoral devices with bipolar endocardial leads. Obstetric/neonatal and cardiac outcomes were assessed during pregnancy and post-partum...
November 2014: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/24459193/incidence-and-prevalence-of-pregnancy-related-heart-disease
#19
REVIEW
Karen Sliwa, Michael Böhm
Worldwide, the numbers of women who have a pre-existing cardiovascular disease or develop cardiac problems during pregnancy are increasing and, due to the lack of evidenced-based data, this provides challenges for the treating physician. Cardiovascular disease in pregnancy is a complex topic as women can present either pre- or post-partum, due to a pre-existing heart disease such as operated on or unoperated on congenital heart disease, valvular heart disease, chronic hypertension, or familial dilated cardiomyopathy...
March 15, 2014: Cardiovascular Research
https://www.readbyqxmd.com/read/24443515/outcomes-of-patients-with-peripartum-cardiomyopathy-who-received-mechanical-circulatory-support-data-from-the-interagency-registry-for-mechanically-assisted-circulatory-support
#20
Renzo Y Loyaga-Rendon, Salpy V Pamboukian, Jose A Tallaj, Deepak Acharya, Ryan Cantor, Randall C Starling, David Naftel, James Kirklin
BACKGROUND: We describe the characteristics and outcomes of peripartum cardiomyopathy (PPCMP) patients who received durable mechanical circulatory support and compared it with other etiologies of advanced heart failure. METHODS AND RESULTS: We analyzed 1258 women who were registered in Interagency Registry for Mechanically Assisted Circulatory Support between June 2006 and March 2012. Baseline characteristics, implant strategies, hemodynamics, echocardiographic data, and outcomes were compared...
March 1, 2014: Circulation. Heart Failure
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