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proton bomb inhibitors

Nelson Cunha, António Pedro Machado
Proton pump inhibitors are currently one of the most prescribed pharmacological classes in developed countries, given their effectiveness and safety profile previously considered favourable. However, over the last few years, several papers have been published that associate prolonged use of these drugs with a wide range of adverse effects, posing doubts about their safety. Among the adverse effects described, one should emphasize the increased risk of cardiovascular events. This relationship was first described in subjects after acute coronary syndrome by the interference of proton pump inhibitors in cytochrome P450 2C19 and the conversion of clopidogrel to active metabolite...
May 24, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Kosuke Okada, Yumiko Yamaguch, Nanao Kamada, Masahiro Okada, Shigeko Katoh, Hidemi Sasaki
AIM: As part of a broader study on polypharmacy among elderly nursing home residents, we examined the impact of reducing or discontinuing the prescription of proton pump inhibitors and other anti-ulcer drugs. METHODS: We employed a strategy of reducing and discontinuing the prescription of drugs to 160 elderly residents of the Hiroshima Atomic Bomb survivors nursing home, Kandayama Yasuragien. The residents had entered the home between April 2012 and November 2015...
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Pedro López-Dóriga Bonnardeaux, Marta Neira Álvarez, Sara Mansilla Laguía
INTRODUCTION: The use of proton pump inhibitors (PPI) has increased exponentially since they were introduced. However concerns have been raised regarding the appropriateness of these prescriptions, and the potential side effects, particularly in frail elderly people, as well as the cost of this treatment. The aim of this study was to assess the extent and appropriateness of PPI prescribing in a group of patients over 65 years old admitted to the functional recovery unit of a medium-stay hospital...
November 2013: Revista Española de Geriatría y Gerontología
João de Souza Coelho-Neto, Nelson Adami Andreollo, Luiz Roberto Lopes, Nancy F Nishimura, Nelson Ary Brandalise, Luiz Sergio Leonardi
BACKGROUND: The gastrectomy is an uncommon procedure because the proton bomb inhibitors associated to the antibiotic outlines used to eradicate the Helicobacter pylori changed the focus of the peptic ulcer treatment. AIMS: Later evaluation on those patients who underwent partial gastrectomy as a treatment for peptic ulcer, at that time when any drug to eradicate the Helicobacter pylori was not used. The clinical evaluation included the late postoperative symptoms and postgastrectomy syndromes like dumping, diarrhea, alkaline gastritis and nutritional aspects...
July 2005: Arquivos de Gastroenterologia
R Ruíz Chávez
Gastric acid, a product of parietal cells secretion, full fills multiple biological roles which are absolutely necessary to keep corporal homeostasis. The production of the acid depends upon an effector cellular process represented in the first step by histamine, acetilcholine and gastrin, first messengers of the process. These interact with specific receptors than in sequence activate second messengers -cAMP and the calcium-calmodulin system- which afterwards activate a kinase. An specific protein is then phosphorilated by this enzyme, being the crucial factor that starts the production of acid...
September 1996: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
J A Ruiz, A Rocca, M T García de Dávila, L Sassón, E Guastavino, S de Rosa
From 1990 to 1998, 12 patients with columnar metaplasia of the lower esophagus were diagnosed. Only 4 of them displayed a Barrett's epithelium (BE) with a specialized columnar epithelium and globet cells. As it is already published, a male predominance was observed. In three of these patients some predisposing factor to develop BE was detected (i.e. severe central nervous system damage, chronic pulmonary disease, esophageal atresia and chemotherapy). All patients had severe gastroesophageal reflux (GER) with abnormal pH probe...
1999: Acta Gastroenterologica Latinoamericana
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