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https://www.readbyqxmd.com/read/29793070/intradialytic-blood-pressure-pattern-recognition-based-on-density-peak-clustering
#1
Feng Wang, Jing-Yi Zhou, Yu Tian, Yu Wang, Ping Zhang, Jiang-Hua Chen, Jing-Song Li
End-stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD) and requires hemodialysis (HD) for survival. Intradialytic blood pressure (IBP) measurements are necessary to ensure patient safety during HD treatments and have critical clinical and prognostic significance. Studies on IBP measurements, especially IBP patterns, are limited. All related studies have been based on a priori knowledge and artificially classified IBP patterns. Therefore, the results were influenced by subjective concepts...
May 21, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29792988/towards-quantitative-prediction-of-the-performance-of-dry-powder-inhalers-by-multi-scale-simulations-and-experiments
#2
Duy Nguyen, Johan Remmelgas, Ingela Niklasson Björn, Berend van Wachem, Kyrre Thalberg
This work demonstrates the use of multi-scale simulations coupled with experiments to build a quantitative prediction tool for the performance of adhesive mixtures in a dry powder inhaler (DPI). Using discrete element model (DEM), the behaviour of fine-carrier particle assemblies upon different mechanisms encountered during dose entrainment and dispersion can be described at the individual particle level. Combining these results with computational fluid dynamics (CFD) simulations, the complete dosing event from a DPI can be captured and key performance measures can be extracted...
May 21, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29792865/aspirin-restores-abt-737-mediated-apoptosis-in-human-renal-carcinoma-cells
#3
Yen-Chuan Ou, Jian-Ri Li, Jiaan-Der Wang, Wen-Ying Chen, Yu-Hsiang Kuan, Ching-Ping Yang, Su-Lan Liao, Hsi-Chi Lu, Chun-Jung Chen
Aspirin is a novel chemopreventive agent against malignancy. However, outcomes of aspirin monotherapy of renal cell carcinoma (RCC) are inconsistent across studies. ABT-737, an BH3 mimetic inhibitor, is also a promising antitumor drug. Cancer cells including those from RCC, that have high levels of Mcl-1, are refractory to ABT-737-induced apoptosis. We here investigated how aspirin treatment modulates the ABT-737-induced apoptosis. Using the in vitro model of human 786-O cells, we showed that aspirin had sensitized cells to ABT-737 induced apoptosis...
May 21, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29792448/the-experimental-evidence-for-parapsychological-phenomena-a-review
#4
Etzel Cardeña
This article presents a comprehensive integration of current experimental evidence and theories about so-called parapsychological (psi) phenomena. Throughout history, people have reported events that seem to violate the common sense view of space and time. Some psychologists have been at the forefront of investigating these phenomena with sophisticated research protocols and theory, while others have devoted much of their careers to criticizing the field. Both stances can be explained by psychologists' expertise on relevant processes such as perception, memory, belief, and conscious and nonconscious processes...
May 24, 2018: American Psychologist
https://www.readbyqxmd.com/read/29792018/predictive-factors-of-a-poor-outcome-following-revascularization-for-critical-limb-ischemia-implications-for-practice
#5
Mireia Martínez, Claudia Sosa, Alina Velescu, Carme Llort, Roberto Elosua, Albert Clarà
BACKGROUND/OBJECTIVE: Advancements in open and endovascular techniques have brought a widespread indication of revascularization in the majority of patients with critical limb ischemia (CLI). However, some cases still have a dismal short-term outcome. Identifying preoperative variables that characterize these patients could be important to prevent futile decisions. The aim of this study was to define predictive risk factors of mortality and/or major amputation after revascularization for CLI...
May 23, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29791865/executive-and-arousal-vigilance-decrement-in-the-context-of-the-attentional-networks-the-anti-vea-task
#6
Fernando Gabriel Luna, Julián Marino, Javier Roca, Juan Lupiáñez
BACKGROUND: Vigilance is generally understood as the ability to detect infrequent critical events through long time periods. In tasks like the Sustained Attention to Response Task (SART), participants tend to detect fewer events across time, a phenomenon known as "vigilance decrement". However, vigilance might also involve sustaining a tonic arousal level. In the Psychomotor Vigilance Test (PVT), the vigilance decrement corresponds to an increment across time in both mean and variability of reaction time...
May 20, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29791247/a-randomized-trial-of-a-family-support-intervention-in-intensive-care-units
#7
Douglas B White, Derek C Angus, Anne-Marie Shields, Praewpannarai Buddadhumaruk, Caroline Pidro, Cynthia Paner, Elizabeth Chaitin, Chung-Chou H Chang, Francis Pike, Lisa Weissfeld, Jeremy M Kahn, Joseph M Darby, Amy Kowinsky, Susan Martin, Robert M Arnold
Background Surrogate decision makers for incapacitated, critically ill patients often struggle with decisions related to goals of care. Such decisions cause psychological distress in surrogates and may lead to treatment that does not align with patients' preferences. Methods We conducted a stepped-wedge, cluster-randomized trial involving patients with a high risk of death and their surrogates in five intensive care units (ICUs) to compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care...
May 23, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791005/no-one-left-behind-postevent-experiences-of-differently-abled-individuals-in-denmark
#8
Adnan Todorovac, Louise Damsbo Simonsen, Ask Elklit
PURPOSE: This descriptive study explored barriers and difficulties faced by individuals with a physical disability (IPD) in Denmark in situations of disaster and in everyday problems. METHODS: Semistructured interviews were conducted with 12 IPD who had experienced a possible traumatic event. Due to a lack of participants who experienced a traumatic event, the authors expanded their recruitment strategy to include IPD, who had experienced other critical situations (eg, accidents and personal crises)...
March 2018: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29791002/optimizing-stadium-evacuation-by-integrating-geocomputation-and-affordance-theory
#9
Joslyn Zale, Bandana Kar, David Cochran
Football is culturally and economically important in the United States, and football stadiums are part of the country's critical infrastructure, thus receiving government protection against hazard events. In this project, an agent-based evacuation model was implemented to optimize evacuation time from The University of Southern Mississippi's M.M. Roberts Stadium (football) by accounting for evacuees' age, gender, physical fitness, alcohol consumption, and prior experience with hazard events. The findings revealed that (i) the age and gender of an individual impact his/her locomotion speed and (ii) evacuation route choice is influenced by evacuees' perception of its safety and effectiveness...
March 2018: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29790720/recanalization-of-ctos-with-soundbitetm-active-wire
#10
Marianne Brodmann, Eric Thérasse, Andrew Benko, Louis-Philippe Riel, Steven Dion, Philippe Généreux, Martin Brouillette
BACKGROUND: The aim of this study was to examine the safety and efficacy of the SoundBite™ Crossing System for the recanalization of infrainguinal chronic total occlusion (CTO) lesions. CTOs are frequent among patients with severe claudication or critical limb ischemia. Failure to recanalize CTOs remains common and is associated with poor prognosis. The SoundBite™ Crossing System (SoundBite Medical Solutions Inc., Montreal, Canada) is a newly developed device that uses a 0.018-inch wire (SoundBite™ Active Wire) to deliver acoustic shock waves to the distal tip of a steerable guidewire to facilitate directed penetration of the proximal cap and crossing of the occlusion...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790143/-managing-the-adverse-effects-related-to-immune-checkpoint-inhibitors
#11
Hsiao-Hsuan Kuo, Wei-Wu Chen
Immune checkpoint inhibitors (ICIs) have become the new posterchild of cancer treatment in recent years largely due to their impressive clinical efficacy. Drugs targeting cytotoxic T- lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death-1 (PD-1) antibodies, e.g., ipilimumab (Yervoy®), pembrolizumab (Keytruda®), and nivolumab (Opdivo®), reinvigorate cytotoxic T cells to kill cancer cells in patients. Despite the impressive clinical benefits, ICIs may induce immune-related adverse events (irAE) of the skin, gastrointestinal tract, liver, endocrine, and lung with a wide spectrum of severity...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29789025/tethered-balloon-technology-in-design-solutions-for-rescue-and-relief-team-emergency-communication-services
#12
Saeed Hamood Alsamhi, Mohd Samar Ansari, Ou Ma, Faris Almalki, Sachin Kumar Gupta
The actions taken at the initial times of a disaster are critical. Catastrophe occurs because of terrorist acts or natural hazards which have the potential to disrupt the infrastructure of wireless communication networks. Therefore, essential emergency functions such as search, rescue, and recovery operations during a catastrophic event will be disabled. We propose tethered balloon technology to provide efficient emergency communication services and reduce casualty mortality and morbidity for disaster recovery...
May 23, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29788771/understanding-design-vulnerabilities-in-the-physical-environment-relating-to-patient-fall-patterns-in-a-psychiatric-hospital-seven-years-of-sentinel-events
#13
Sara Bayramzadeh, Margaret Portillo, Candy Carmel-Gilfilen
BACKGROUND: The influence of the physical environment on patient falls has not been fully explored in psychiatric units, despite this patient population's vulnerability and the critical role of the physical environment in patient safety. AIMS: The research objective is to describe the spatial and temporal pattern of falls occurrences and their location in relation to the levels of safety continuum model. METHOD: This article presents an exploratory case study design...
May 1, 2018: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/29788455/a-10-yr-analysis-of-chronic-pelvic-pain-and-chronic-opioid-therapy-in-the-women-veteran-population
#14
Sara B Cichowski, Rebecca G Rogers, Yuko Komesu, Erin Murata, Clifford Qualls, Allison Murata, Glen Murata
Introduction: Chronic pelvic pain (CPP) affects an estimated 30% of women Veterans. Previous research shows high rates of narcotic abuse in the women Veteran population. Narcotics are not recommended for the treatment of CPP. Understanding how CPP impacts narcotic prescribing in the women Veteran population is critical to addressing the public health crisis of opioid abuse. Our objective was to compare chronic opioid therapy (COT) prescribed 5 yr prior to and following CPP diagnosis and to identify predictors of COT as well as adverse events associated with COT...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29788330/the-evolution-of-gene-expression-underlying-vision-loss-in-cave-animals
#15
David B Stern, Keith A Crandall
Dissecting the evolutionary genetic processes underlying eye reduction and vision loss in obligate cave-dwelling organisms has been a long-standing challenge in evolutionary biology. Independent vision loss events in related subterranean organisms can provide critical insight into these processes as well as into the nature of convergent loss of complex traits. Advances in evolutionary developmental biology have illuminated the significant role of heritable gene expression variation in the evolution of new forms...
May 21, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29787763/the-torc1-signaling-pathway-regulates-respiration-induced-mitophagy-in-yeast
#16
Yang Liu, Koji Okamoto
Mitophagy is an evolutionarily conserved autophagy process that selectively degrades mitochondria. This catabolic event is considered to be a mitochondrial quality control system crucial for cell homeostasis, however, mechanisms regulating mitophagy remain largely unknown. Here we show that the TORC1 (target of rapamycin complex 1) signaling pathway regulates mitophagy in budding yeast via SEACIT (Seh1-associated complex inhibiting TORC1) consisting of Iml1, Npr2, and Npr3. Cells lacking SEACIT displayed significant reductions in mitophagy during prolonged respiratory growth, while the other selective autophagy processes are less affected...
May 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29787325/barriers-to-self-reporting-patient-safety-incidents-by-paramedics-a-mixed-methods-study
#17
Julie E Sinclair, Michael A Austin, Christopher Bourque, Jennifer Kortko, Justin Maloney, Richard Dionne, Andrew Reed, Penny Price, Lisa A Calder
BACKGROUND: A minimal amount of research exists examining the extent to which patient safety events occur within paramedicine and even fewer studies investigating patient safety systems for self-reporting by paramedics. The purpose of this study was to identify barriers to paramedic self-reporting of patient safety incidents (PSIs). METHODS: We randomly distributed paper-based surveys among 1,153 paramedics in an Ontario region in Canada. The survey described one of 5 different PSI clinical scenarios (near miss, adverse event, and minor, major or critical patient care variances) and listed 18 potential barriers to self-reporting PSIs as statements presented for rating on a 5-point Likert scale (very significant = 1 - very insignificant = 5)...
May 22, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29786653/role-for-cystathionine-%C3%AE-lyase-cse-in-an-ethanol-e-induced-lesion-in-fetal-brain-gsh-homeostasis
#18
Dhyanesh Patel, Marylatha Rathinam, Courtney Jarvis, Lenin Mahimainathan, George Henderson, Madhusudhanan Narasimhan
Earlier, we reported that gestational ethanol (E) can dysregulate neuron glutathione (GSH) homeostasis partially via impairing the EAAC1-mediated inward transport of Cysteine (Cys) and this can affect fetal brain development. In this study, we investigated if there is a role for the transulfuration pathway (TSP), a critical bio-synthetic point to supply Cys in E-induced dysregulation of GSH homeostasis. These studies utilized an in utero E binge model where the pregnant Sprague⁻Dawley (SD) rat dams received five doses of E at 3...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29785967/eighty-routes-to-a-ribonucleotide-world-dispersion-and-stringency-in-the-decisive-selection
#19
Michael Yarus
We examine the initial emergence of genetics; that is, of an inherited chemical capability. The crucial actors are ribonucleotides, occasionally meeting in a prebiotic landscape. Previous work identified six influential variables during such random ribonucleotide pooling. Geochemical pools can be in periodic danger (e.g., from tides) or constant danger (e.g., from unfavorable weather). Such pools receive Gaussian nucleotide amounts sporadically, at random times, or get varying substrates simultaneously. Pools use cross-templated RNA synthesis (5'-5' product from 5'-3' template) or para-templated (5'-5' product from 5'-5' template) synthesis...
May 21, 2018: RNA
https://www.readbyqxmd.com/read/29785851/a-red-emitting-fluorescent-probe-for-detection-of-%C3%AE-glutamyltranspeptidase-and-its-application-of-real-time-imaging-under-oxidative-stress-in-cells-and-in-vivo
#20
Feiyan Liu, Zhen Wang, Wenli Wang, Jian-Guang Luo, Lingyi Kong
γ-Glutamyltranspeptidase (GGT) plays critical roles in regulating various physiological/pathophysiological processes including the intracellular redox homeostasis. However, an effective fluorescent probe for dissecting the relationships between GGT and oxidative stress in vivo remains largely unexplored. Herein, we present a light-up fluorescent probe (DCDHF-Glu) with long wavelength emission (613 nm) for the highly sensitive and selective detection of GGT using dicyanomethylenedihydrofuran derivative as the fluorescent reporter and γ-glutamyl group as the enzyme-active trigger...
May 22, 2018: Analytical Chemistry
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