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https://www.readbyqxmd.com/read/29331611/resistance-to-peer-influence-moderates-the-relationship-between-perceived-but-not-actual-peer-norms-and-binge-drinking-in-a-college-student-social-network
#1
Graham T DiGuiseppi, Matthew K Meisel, Sara G Balestrieri, Miles Q Ott, Melissa J Cox, Melissa A Clark, Nancy P Barnett
INTRODUCTION: Adolescent and young adult binge drinking is strongly associated with perceived social norms and the drinking behavior that occurs within peer networks. The extent to which an individual is influenced by the behavior of others may depend upon that individual's resistance to peer influence (RPI). METHODS: Students in their first semester of college (N=1323; 54.7% female, 57% White, 15.1% Hispanic) reported on their own binge drinking, and the perceived binge drinking of up to 10 important peers in the first-year class...
December 20, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29319374/sensitive-and-specific-assessment-of-recombinant-von-willebrand-factor-in-platelet-function-analyzer
#2
Isabell Pekrul, Thorsten Kragh, Peter L Turecek, Aaron R Novack, Helmut W Ott, Michael Spannagl
BACKGROUND: Recombinant von Willebrand factor (rVWF), which was licensed in the United States in 2015, has the multimeric distribution of freshly secreted VWF with ultralarge (UL) and high molecular weight multimers (HMWM) from endothelial cells and megakaryocytes since it has never been exposed to ADAMTS13 or any other proteolytic enzyme. Measurement of closure time (CT) using the platelet function analyzer-200 (PFA-200) is highly sensitive to the presence of UL VWF multimers in added VWF concentrates...
January 10, 2018: Platelets
https://www.readbyqxmd.com/read/29303305/spin-orbit-semimetal-sriro_-3-in-the-two-dimensional-limit
#3
D J Groenendijk, C Autieri, J Girovsky, M Carmen Martinez-Velarte, N Manca, G Mattoni, A M R V L Monteiro, N Gauquelin, J Verbeeck, A F Otte, M Gabay, S Picozzi, A D Caviglia
We investigate the thickness-dependent electronic properties of ultrathin SrIrO_{3} and discover a transition from a semimetallic to a correlated insulating state below 4 unit cells. Low-temperature magnetoconductance measurements show that spin fluctuations in the semimetallic state are significantly enhanced while approaching the transition point. The electronic properties are further studied by scanning tunneling spectroscopy, showing that 4 unit cell SrIrO_{3} is on the verge of a gap opening. Our density functional theory calculations reproduce the critical thickness of the transition and show that the opening of a gap in ultrathin SrIrO_{3} requires antiferromagnetic order...
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29300825/the-arabidopsis-thaliana-non-specific-phospholipase-c2-is-involved-in-the-response-to-pseudomonas-syringae-attack
#4
Zuzana Krcková, Daniela Kocourková, Michal Danek, Jitka Brouzdová, Premysl Pejchar, Martin Janda, Igor Pokotylo, Peter G Ott, Olga Valentová, Jan Martinec
Background and Aims: The non-specific phospholipase C (NPC) is a new member of the plant phospholipase family that reacts to abiotic environmental stresses, such as phosphate deficiency, high salinity, heat and aluminium toxicity, and is involved in root development, silicon distribution and brassinolide signalling. Six NPC genes (NPC1-NPC6) are found in the Arabidopsis genome. The NPC2 isoform has not been experimentally characterized so far. Methods: The Arabidopsis NPC2 isoform was cloned and heterologously expressed in Escherichia coli...
December 29, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29291510/an-event-and-network-level-analysis-of-college-students-maximum-drinking-day
#5
Matthew K Meisel, Angelo M DiBello, Sara G Balestrieri, Miles Q Ott, Graham T DiGuiseppi, Melissa A Clark, Nancy P Barnett
BACKGROUND: Heavy episodic drinking is common among college students and remains a serious public health issue. Previous event-level research among college students has examined behaviors and individual-level characteristics that drive consumption and related consequences but often ignores the social network of people with whom these heavy drinking episodes occur. The main aim of the current study was to investigate the network of social connections between drinkers on their heaviest drinking occasions...
December 27, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29290397/antibacterial-potential-of-the-cistus-incanus-l-phenolics-as-studied-with-use-of-thin-layer-chromatography-combined-with-direct-bioautography-and-in-situ-hydrolysis
#6
Ágnes M Móricz, Dariusz Szeremeta, Magdalena Knaś, Ewa Długosz, Péter G Ott, Teresa Kowalska, Mieczysław Sajewicz
The main aim of this study was to detect and identify antibacterial components of fraction I derived from eleven commercial C. incanus herbal teas. Fraction I obtained by a well-established phytochemical protocol of a multi-step extraction was expected to contain flavonoid aglycons alone. Antibacterial profile of fraction I was demonstrated by means of thin-layer chromatography - direct bioautography (TLC-DB) using a Gram positive B. subtilis and a Gram negative A. fischeri strain. Six chromatographic zones of fraction I exhibited a well pronounced antibacterial potential...
December 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29284064/policies-for-biosimilar-uptake-in-europe-an-overview
#7
Evelien Moorkens, Arnold G Vulto, Isabelle Huys, Pieter Dylst, Brian Godman, Simon Keuerleber, Barbara Claus, Maria Dimitrova, Guenka Petrova, Ljiljana Sović-Brkičić, Juraj Slabý, Robin Šebesta, Ott Laius, Allan Karr, Morgane Beck, Jaana E Martikainen, Gisbert W Selke, Susan Spillane, Laura McCullagh, Gianluca Trifirò, Patricia Vella Bonanno, Asbjørn Mack, Antra Fogele, Anita Viksna, Magdalena Władysiuk, Helder Mota-Filipe, Dmitry Meshkov, Marija Kalaba, Simona Mencej Bedrač, Jurij Fürst, Corrine Zara, Peter Skiöld, Einar Magnússon, Steven Simoens
BACKGROUND: Across European countries, differences exist in biosimilar policies, leading to variations in uptake of biosimilars and divergences in savings all over Europe. OBJECTIVES: The aim of this article is to provide an overview of different initiatives and policies that may influence the uptake of biosimilars in different European countries. Recommendations will be formulated on how to create sustainable uptake. METHODS: An overview of policies on biosimilars was obtained via a questionnaire, supplemented with relevant articles...
2017: PloS One
https://www.readbyqxmd.com/read/29227201/early-rescue-from-acute-severe-clostridium-difficile-a-novel-treatment-strategy
#8
Biniam Kidane, Kalvin Lung, Greig McCreery, Chadia El-Khatib, Michael C Ott, Roberto Hernandez-Alejandro, Chris Vinden, Daryl Gray, Neil G Parry, Kenneth A Leslie, Tina S Mele
BACKGROUND: Severe Clostridium difficile infections (CDI) can lead to significant impediments to effective treatment. We developed a novel treatment protocol utilizing bedside gastrointestinal lavage (GIL) for the management of patients with severe, complicated CDI. We describe the development and early outcomes of non-operative bedside GIL in hospitalized patients with severe, complicated CDI following the Idea, Development, Exploration, Assessment, Long Term Study (IDEAL) framework at the Idea stage...
December 11, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29219430/gravitational-waves-from-binary-black-hole-mergers-inside-stars
#9
Joseph M Fedrow, Christian D Ott, Ulrich Sperhake, Jonathan Blackman, Roland Haas, Christian Reisswig, Antonio De Felice
We present results from a controlled numerical experiment investigating the effect of stellar density gas on the coalescence of binary black holes (BBHs) and the resulting gravitational waves (GWs). This investigation is motivated by the proposed stellar core fragmentation scenario for BBH formation and the associated possibility of an electromagnetic counterpart to a BBH GW event. We employ full numerical relativity coupled with general-relativistic hydrodynamics and set up a 30+30  M_{⊙} BBH (motivated by GW150914) inside gas with realistic stellar densities...
October 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29165623/effects-of-pharmacologic-and-nonpharmacologic-interventions-on-insomnia-symptoms-and-subjective-sleep-quality-in-women-with-hot-flashes-a-pooled-analysis-of-individual-participant-data-from-4-msflash-trials
#10
Katherine A Guthrie, Joseph C Larson, Kristine E Ensrud, Garnet L Anderson, Janet S Carpenter, Ellen W Freeman, Hadine Joffe, Andrea Z LaCroix, JoAnn E Manson, Charles M Morin, Katherine M Newton, Julie Otte, Susan D Reed, Susan M McCurry
Study Objectives: The Menopause Strategies: Finding Lasting Answers for Symptoms and Health network conducted three randomized clinical trials (RCT) testing six interventions treating vasomotor symptoms (VMS), and also collected self-reported sleep outcomes. A fourth RCT assessed an intervention for insomnia symptoms among women with VMS. We describe these seven interventions' effects relative to control in women with comparably severe insomnia symptoms and VMS. Methods: We analyzed pooled individual-level data from 546 peri- and postmenopausal women with Insomnia Severity Index (ISI) >12, and ≥14 bothersome VMS/week across the four RCTs...
November 20, 2017: Sleep
https://www.readbyqxmd.com/read/29153353/-something-humane-has-been-lost-re-evaluation-of-the-attitudes-of-senior-physicians-towards-the-g-drg-system-a-qualitative-normative-analysis
#11
Marco Knoll, Ina Otte, Sabine Salloch, Caroline Ruiner, Esta Kruppa, Jochen Vollmann
Only a few years after the implementation of the G-DRG (German Diagnosis Related Group) system physicians already began to complain of its negative effects on the quality of inpatient healthcare. The present study examines the recent experiences senior physicians have made with regard to the impact of the G-DRG system on the quality of healthcare and medical professionalism. Nine qualitative guided expert interviews were conducted focusing on the experiences of physicians in leading positions dealing with the G-DRG system in their everyday work...
November 15, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29143551/independent-validation-of-the-icu-requirement-score-in-a-cohort-of-acutely-poisoned-adults
#12
Regina Böll, Katrin Romanek, Sabrina Schmoll, Raphael Stich, Armin Ott, Jochen Stenzel, Stefanie Geith, Florian Eyer, Christian Rabe
OBJECTIVE: To independently validate the predictive value of the intensive care requirement score (IRS) in unselected poisoned patients. DESIGN: Retrospective chart review. PATIENTS AND METHODS: Five hundred and seventeen out of 585 admissions for acute intoxications could be analyzed. Eleven were excluded for a condition already requiring intensive care unit (ICU) support at admission (e.g., preclinical intubation). A further 57 admissions were excluded due to missing data...
November 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29127566/monitoring-and-treating-metabolic-abnormalities-in-patients-with-early-psychosis-initiated-on-antipsychotic-medications
#13
Kevin M Bozymski, Jessica A Whitten, Mary E Blair, Ashley M Overley, Carol A Ott
Antipsychotic medications carry an established lifetime risk of metabolic syndrome. This retrospective chart review evaluated feasibility of a metabolic monitoring clinical decision support tool (CDST) for weight, lipid, blood glucose, and blood pressure management of 163 clients in an early psychosis outpatient clinic over 2 years. Each parameter had at least 98 (60.1%) clients with a recorded value, the most being documented for weight with 112 (68.7%) clients. CDST adherence ranged from at least 54.3-100% for non-pharmacologic interventions (e...
November 11, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29125984/ultraviolet-germicidal-efficacy-as-a-function-of-pulsed-radiation-parameters-studied-by-spore-film-dosimetry
#14
Stefan Bauer, Hans Holtschmidt, Günter Ott
Disinfection by pulsed ultraviolet (UV) radiation is a commonly used method, e.g. in industry or medicine and can be carried out either with lasers or broadband UV radiation sources. Detrimental effects to biological materials depending on parameters such as pulse duration τ or pulse repetition frequency fp are well-understood for pulsed coherent UV radiation, however, relatively little is known for its incoherent variant. Therefore, within this work, it is the first time that disinfection rates of pulsed and continuous (cw) incoherent UV radiation studied by means of spore film dosimetry are presented, compared with each other, and in a second step further investigated regarding two pulse parameters...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29102034/under-reporting-bicycle-accidents-to-police-in-the-cost-tu1101-international-survey-cross-country-comparisons-and-associated-factors
#15
D Shinar, P Valero-Mora, M van Strijp-Houtenbos, N Haworth, A Schramm, Guido De Bruyne, V Cavallo, J Chliaoutakis, J Dias, O E Ferraro, A Fyhri, A Hursa Sajatovic, K Kuklane, R Ledesma, O Mascarell, A Morandi, M Muser, D Otte, M Papadakaki, J Sanmartín, D Dulf, M Saplioglu, G Tzamalouka
Police crash reports are often the main source for official data in many countries. However, with the exception of fatal crashes, crashes are often underreported in a biased manner. Consequently, the countermeasures adopted according to them may be inefficient. In the case of bicycle crashes, this bias is most acute and it probably varies across countries, with some of them being more prone to reporting accidents to police than others. Assessing if this bias occurs and the size of it can be of great importance for evaluating the risks associated with bicycling...
October 26, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29101162/ex-vivo-profiling-of-pd-1-blockade-using-organotypic-tumor-spheroids
#16
Russell W Jenkins, Amir R Aref, Patrick H Lizotte, Elena Ivanova, Susanna Stinson, Chensheng W Zhou, Michaela Bowden, Jiehui Deng, Hongye Liu, Diana Miao, Meng Xiao He, William Walker, Gao Zhang, Tian Tian, Chaoran Cheng, Zhi Wei, Sangeetha Palakurthi, Mark Bittinger, Hans Vitzthum, Jong Wook Kim, Ashley Merlino, Max Quinn, Chandrasekar Venkataramani, Joshua A Kaplan, Andrew Portell, Prafulla C Gokhale, Bart Phillips, Alicia Smart, Asaf Rotem, Robert E Jones, Lauren Keogh, Maria Anguiano, Lance Stapleton, Zhiheng Jia, Michal Barzily-Rokni, Israel Cañadas, Tran C Thai, Marc R Hammond, Raven Vlahos, Eric S Wang, Hua Zhang, Shuai Li, Glenn J Hanna, Wei Huang, Mai P Hoang, Adriano Piris, Jean-Pierre Eliane, Anat O Stemmer-Rachamimov, Lisa Cameron, Mei-Ju Su, Parin Shah, Benjamin Izar, Manisha Thakuria, Nicole R LeBoeuf, Guilherme Rabinowits, Viswanath Gunda, Sareh Parangi, James M Cleary, Brian C Miller, Shunsuke Kitajima, Rohit Thummalapalli, Benchun Miao, Thanh U Barbie, Vivek Sivathanu, Joshua Wong, William G Richards, Raphael Bueno, Charles H Yoon, Juan Miret, Meenhard Herlyn, Levi A Garraway, Eliezer M Van Allen, Gordon J Freeman, Paul T Kirschmeier, Jochen H Lorch, Patrick A Ott, F Stephen Hodi, Keith T Flaherty, Roger D Kamm, Genevieve M Boland, Kwok-Kin Wong, David Dornan, Cloud Peter Paweletz, David A Barbie
Ex vivo systems that incorporate features of the tumor microenvironment (TME) and model the dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision immuno-oncology and the development of effective combination therapies. Here, we demonstrate the ability to interrogate ex vivo response to ICB using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS). MDOTS/PDOTS isolated from mouse and human tumors retain autologous lymphoid and myeloid cell populations, and respond to ICB in short-term 3-dimensional microfluidic culture...
November 3, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29094590/discrepancies-and-uncertainties-in-bottom-up-gridded-inventories-of-livestock-methane-emissions-for-the-contiguous-united-states
#17
Alexander Hristov, Michael Harper, Robert Meinen, Rick Day, Juliana Lopes, Troy L Ott, Aranya Venkatesh, Cynthia A Randles
In this analysis we used a spatially-explicit, simplified bottom-up approach, based on animal inventories, feed dry matter intake, and feed intake-based emission factors to estimate county-level enteric methane emissions for cattle and manure methane emissions for cattle, swine, and poultry for the contiguous United States. Overall, this analysis yielded total livestock methane emissions (8,916 Gg/yr; lower and upper 95% confidence bounds of ±19.3%) for 2012 (last census of agriculture) that are comparable to the current USEPA estimates for 2012 and to estimates from the global gridded Emission Database for Global Atmospheric Research (EDGAR) inventory...
November 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29069277/a-novel-pretherapeutic-gene-expression-based-risk-score-for-treatment-guidance-in-gastric-cancer
#18
L Bauer, A Hapfelmeier, S Blank, M Reiche, J Slotta-Huspenina, M Jesinghaus, A Novotny, T Schmidt, B Grosser, M Kohlruss, W Weichert, K Ott, G Keller
Background: Perioperative chemotherapy is an established treatment for advanced gastric cancer patients. Treatment selection is based on clinical staging (cT). We aimed to establish and validate a prognostic score including clinical and molecular factors, to optimize treatment decisions for these patients. Patients and methods: We analyzed 626 carcinomas of the stomach and of the gastro-oesophageal junction from two academic centers including primarily resected and pre-/perioperatively treated patients...
October 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29061728/central-iliac-arteriovenous-anastomosis-for-uncontrolled-hypertension-one-year-results-from-the-rox-control-htn-trial
#19
RANDOMIZED CONTROLLED TRIAL
Melvin D Lobo, Christian Ott, Paul A Sobotka, Manish Saxena, Alice Stanton, John R Cockcroft, Neil Sulke, Eamon Dolan, Markus van der Giet, Joachim Hoyer, Stephen S Furniss, John P Foran, Adam Witkowski, Andrzej Januszewicz, Danny Schoors, Konstantinos Tsioufis, Benno J Rensing, Benjamin Scott, G André Ng, Roland E Schmieder
Creation of a central iliac arteriovenous anastomosis using a novel nitinol coupler device results in an immediate, significant reduction of blood pressure (BP). We present efficacy and safety findings at 12 months post-coupler insertion. This open-label, multicenter, prospective, randomized trial enrolled patients with a baseline office systolic BP ≥140 mm Hg and average daytime ambulatory BP ≥135/85 mm Hg. Subjects were randomly allocated to coupler implantation and continuing previous pharmacotherapy or to maintain previous treatment alone...
December 2017: Hypertension
https://www.readbyqxmd.com/read/29058480/clinical-and-demographic-predictors-of-concussion-resolution-in-adolescents-a-retrospective-study
#20
Seema S Aggarwal, Summer D Ott, Nikhil S Padhye, Janet C Meininger, Terri S Armstrong
Concussions in adolescents are a growing public health concern. The aim of this study was to identify clinical (e.g., concussion history, migraine history, learning disabilities/ADHD) and demographic factors (e.g., age, sex, race, health insurance status, mechanism of injury, education) that predict concussion recovery times. In a retrospective cohort study of 118 adolescents 13-19 years old who were evaluated for an acute concussion (≤10 days from injury), recovery times were calculated from the date of concussive injury to the date of clearance to return to play and/or normal activities...
October 23, 2017: Applied Neuropsychology. Child
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