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https://www.readbyqxmd.com/read/28070820/development-of-a-new-catheter-prototype-for-laser-thrombolysis-under-guidance-of-optical-coherence-tomography-oct-validation-of-feasibility-and-efficacy-in-a-preclinical-model
#1
Rouven Berndt, Rene Rusch, Lars Hummitzsch, Matthias Lutz, Katharina Heß, Katharina Huenges, Bernd Panholzer, Christoph Otte, Assad Haneya, Georg Lutter, Alexander Schlaefer, Jochen Cremer, Justus Groß
In this feasibility study, a novel catheter prototype for laser thrombolysis under the guidance of optical coherence tomography (OCT) was designed and evaluated in a preclinical model. Human arteries and veins were integrated into a physiological flow model and occluded with thrombi made from the Chandler Loop. There were four experimental groups: placebo, 20 mg alteplase, laser, 20 mg alteplase + laser. The extent of thrombolysis was analyzed by weighing, OCT imaging and relative thrombus size. In the alteplase group, thrombus size decreased to 0...
January 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28070657/-how-to-incorporate-dual-energy-imaging-into-a-high-volume-abdominal-imaging-practice
#2
Eric P Tamm, Ott Le, Xinming Liu, Rick R Layman, Dianna D Cody, Priya R Bhosale
Dual-energy CT imaging has many potential uses in abdominal imaging. It also has unique requirements for protocol creation depending on the dual-energy scanning technique that is being utilized. It also generates several new types of images which can increase the complexity of image creation and image interpretation. The purpose of this article is to review, for rapid switching and dual-source dual-energy platforms, methods for creating dual-energy protocols, different approaches for efficiently creating dual-energy images, and an approach to navigating and using dual-energy images at the reading station all using the example of a pancreatic multiphasic protocol...
January 9, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28059802/recent-progress-in-translational-research-on-neurovascular-and-neurodegenerative-disorders
#3
Hans-Ulrich Demuth, Rick M Dijkhuizen, Tracy D Farr, Mathias Gelderblom, Karen Horsburgh, Costantino Iadecola, Damian D Mcleod, Dominik Michalski, Tim H Murphy, Josune Orbe, Willem M Otte, Gabor C Petzold, Nikolaus Plesnila, Georg Reiser, Klaus G Reymann, Maria A Rueger, Dorothee Saur, Sean I Savitz, Stephan Schilling, Neil J Spratt, Renée J Turner, Raghu Vemuganti, Denis Vivien, Manuel Yepes, Marietta Zille, Johannes Boltze
The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient's outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience...
January 3, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28041697/validity-of-the-j-cto-score-and-the-cl-score-for-predicting-successful-cto-recanalization
#4
J E Guelker, L Bansemir, R Ott, T Rock, K Kroeger, R Guelker, H G Klues, D I Shin, A Bufe
BACKGROUND: Percutaneous coronary intervention (PCI) of total chronic coronary occlusion (CTO) still remains a major challenge in interventional cardiology. To predict the probability of a successful intervention different scoring systems are available. We analyzed in this study the validity of two scoring systems, the Japanese CTO score (J-CTO score) and the newly developed Clinical and Lesion-related score (CL Score). METHODS: Between 2012 and 2015 we included 379 consecutive patients...
December 27, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28008609/randomized-trial-of-the-family-intervention-telephone-tracking-caregiver-for-dementia-caregivers-use-of-community-and-healthcare-resources
#5
Geoffrey Tremont, Jennifer D Davis, Brian R Ott, Rachel Galioto, Cara Crook, George D Papandonatos, Richard H Fortinsky, Pedro Gozalo, Duane S Bishop
OBJECTIVES: To examine the effects of a telephone-delivered intervention, Family Intervention: Telephone Tracking-Caregiver (FITT-C), on community support and healthcare use by dementia caregivers. DESIGN: Randomized, controlled trial. SETTING: Academic medical center. PARTICIPANTS: Dyads (n = 250) of distressed informal dementia caregivers and care recipients. INTERVENTION: Caregivers were randomly assigned to receive the FITT-C (n = 133) or telephone support (TS; n = 117)...
December 23, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28003343/ectodomain-shedding-of-cd99-within-highly-conserved-regions-is-mediated-by-the-metalloprotease-meprin-%C3%AE-and-promotes-transendothelial-cell-migration
#6
Tillmann Bedau, Florian Peters, Johannes Prox, Philipp Arnold, Frederike Schmidt, Malin Finkernagel, Sandra Köllmann, Rielana Wichert, Anna Otte, Anke Ohler, Marit Stirnberg, Ralph Lucius, Tomas Koudelka, Andreas Tholey, Valentina Biasin, Claus U Pietrzik, Grazyna Kwapiszewska, Christoph Becker-Pauly
The adhesion molecule CD99 is essential for the transendothelial migration of leukocytes. In this study, we used biochemical and cellular assays to show that CD99 undergoes ectodomain shedding by the metalloprotease meprin β and subsequent intramembrane proteolysis by γ-secretase. The cleavage site in CD99 was identified by mass spectrometry within an acidic region highly conserved through different vertebrate species. This finding fits perfectly to the unique cleavage specificity of meprin β with a strong preference for aspartate residues and suggests coevolution of protease and substrate...
December 21, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28003251/effect-of-arteriovenous-anastomosis-on-blood-pressure-reduction-in-patients-with-isolated-systolic-hypertension-compared-with-combined-hypertension
#7
Christian Ott, Melvin D Lobo, Paul A Sobotka, Felix Mahfoud, Alice Stanton, John Cockcroft, Neil Sulke, Eamon Dolan, Markus van der Giet, Joachim Hoyer, Stephen S Furniss, John P Foran, Adam Witkowski, Andrzej Januszewicz, Danny Schoors, Konstantinos Tsioufis, Benno J Rensing, Manish Saxena, Benjamin Scott, G André Ng, Stephan Achenbach, Roland E Schmieder
BACKGROUND: Options for interventional therapy to lower blood pressure (BP) in patients with treatment-resistant hypertension include renal denervation and the creation of an arteriovenous anastomosis using the ROX coupler. It has been shown that BP response after renal denervation is greater in patients with combined hypertension (CH) than in patients with isolated systolic hypertension (ISH). We analyzed the effect of ROX coupler implantation in patients with CH as compared with ISH...
December 21, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27997743/metal-nhc-complexes-with-naphthalimide-ligands-as-dna-interacting-antiproliferative-agents
#8
Wojciech Streciwilk, Alessio Terenzi, Rainer Misgeld, Corazon Frias, Peter G Jones, Aram Prokop, Bernhard Keppler, Ingo Ott
Naphthalimide-based N-heterocyclic carbene (NHC) complexes of the type [(COD)(NHC)RhCl) (4a-c), [(p-cymene)(NHC)RuCl2) (5a-c) and [(NHC)CuBr] (6a-c) were synthesised and investigated as antiproliferative agents that target DNA. The cytotoxic effects were largely driven by the naphthalimide structure, which represents a DNA intercalating moiety. Regarding the metal centre, the highest activities were observed with the rhodium complexes and the cytotoxic activity was strongly decreased for the ruthenium derivatives...
December 20, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27910389/overview-of-diagnostic-performance-and-results-for-the-first-operation-phase-in-wendelstein-7-x-invited
#9
M Krychowiak, A Adnan, A Alonso, T Andreeva, J Baldzuhn, T Barbui, M Beurskens, W Biel, C Biedermann, B D Blackwell, H S Bosch, S Bozhenkov, R Brakel, T Bräuer, B Brotas de Carvalho, R Burhenn, B Buttenschön, A Cappa, G Cseh, A Czarnecka, A Dinklage, P Drews, A Dzikowicka, F Effenberg, M Endler, V Erckmann, T Estrada, O Ford, T Fornal, H Frerichs, G Fuchert, J Geiger, O Grulke, J H Harris, H J Hartfuß, D Hartmann, D Hathiramani, M Hirsch, U Höfel, S Jabłoński, M W Jakubowski, J Kaczmarczyk, T Klinger, S Klose, J Knauer, G Kocsis, R König, P Kornejew, A Krämer-Flecken, N Krawczyk, T Kremeyer, I Książek, M Kubkowska, A Langenberg, H P Laqua, M Laux, S Lazerson, Y Liang, S C Liu, A Lorenz, A O Marchuk, S Marsen, V Moncada, D Naujoks, H Neilson, O Neubauer, U Neuner, H Niemann, J W Oosterbeek, M Otte, N Pablant, E Pasch, T Sunn Pedersen, F Pisano, K Rahbarnia, L Ryć, O Schmitz, S Schmuck, W Schneider, T Schröder, H Schuhmacher, B Schweer, B Standley, T Stange, L Stephey, J Svensson, T Szabolics, T Szepesi, H Thomsen, J-M Travere, H Trimino Mora, H Tsuchiya, G M Weir, U Wenzel, A Werner, B Wiegel, T Windisch, R Wolf, G A Wurden, D Zhang, A Zimbal, S Zoletnik
Wendelstein 7-X, a superconducting optimized stellarator built in Greifswald/Germany, started its first plasmas with the last closed flux surface (LCFS) defined by 5 uncooled graphite limiters in December 2015. At the end of the 10 weeks long experimental campaign (OP1.1) more than 20 independent diagnostic systems were in operation, allowing detailed studies of many interesting plasma phenomena. For example, fast neutral gas manometers supported by video cameras (including one fast-frame camera with frame rates of tens of kHz) as well as visible cameras with different interference filters, with field of views covering all ten half-modules of the stellarator, discovered a MARFE-like radiation zone on the inboard side of machine module 4...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909737/-attitudes-towards-psychotherapy-in-south-korea-and-germany-a%C3%A2-cross-cultural-comparative-study
#10
W Schulz, M A Shin, G Schmid-Ott
BACKGROUND: Due to the relatively recent introduction of psychotherapy in South Korea and against the background of collectivist and Confucian values, it has been suggested that South Koreans harbor more negative attitudes towards psychotherapy compared to Germans and that the social acceptance of psychotherapy is lower. METHODS: We compared the attitudes of 99 women from South Korea with 98 German women using the questionnaire on attitudes towards psychotherapeutic treatment (FEP)...
December 1, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27882298/high-frequency-oscillations-and-high-frequency-functional-network-characteristics-in-the-intraoperative-electrocorticogram-in-epilepsy
#11
W J E M Zweiphenning, M A van 't Klooster, E van Diessen, N E C van Klink, G J M Huiskamp, T A Gebbink, F S S Leijten, P H Gosselaar, W M Otte, C J Stam, K P J Braun, G J M Zijlmans
OBJECTIVE: High frequency oscillations (HFOs; > 80 Hz), especially fast ripples (FRs, 250-500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas showing FRs and 'baseline' functional connectivity within EEG networks, especially in the high frequency bands. METHODS: We marked FRs, ripples (80-250 Hz) and spikes in the electrocorticogram of 14 patients with refractory temporal lobe epilepsy...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27821887/times-to-key-events-in-zika-virus-infection-and-implications-for-blood-donation-a-systematic-review
#12
REVIEW
Justin Lessler, Cassandra T Ott, Andrea C Carcelen, Jacob M Konikoff, Joe Williamson, Qifang Bi, Lauren M Kucirka, Derek At Cummings, Nicholas G Reich, Lelia H Chaisson
OBJECTIVE: To estimate the timing of key events in the natural history of Zika virus infection. METHODS: In February 2016, we searched PubMed, Scopus and the Web of Science for publications containing the term Zika. By pooling data, we estimated the incubation period, the time to seroconversion and the duration of viral shedding. We estimated the risk of Zika virus contaminated blood donations. FINDINGS: We identified 20 articles on 25 patients with Zika virus infection...
November 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27806658/the-association-between-maternal-hydronephrosis-and-acute-flank-pain-during-pregnancy-a-prospective-pilot-study
#13
Alex Farr, Johannes Ott, Verena Kueronya, Markus Margreiter, Elchin Javadli, Sabrina Einig, Peter W Husslein, Dagmar Bancher-Todesca
PURPOSE: Maternal hydronephrosis may cause flank pain during pregnancy. We aimed to investigate the association between maternal hydronephrosis and flank pain intensity. METHODS: From 2014 to 2015, all consecutive women with singleton pregnancies, who presented at our tertiary center due to acute flank pain, were prospectively evaluated by renal ultrasonography and pain questionnaires. A visual analogue scale was used to assess pain intensity. The study had 90% power to detect a significant correlation between hydronephrosis and flank pain (Spearman's test)...
November 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27791035/mirna92a-targets-klf2-and-the-phosphatase-pten-signaling-to-promote-human-t-follicular-helper-precursors-in-t1d-islet-autoimmunity
#14
Isabelle Serr, Rainer W Fürst, Verena B Ott, Martin G Scherm, Alexei Nikolaev, Füsun Gökmen, Stefanie Kälin, Stephanie Zillmer, Melanie Bunk, Benno Weigmann, Nicole Kunschke, Brigitta Loretz, Claus-Michael Lehr, Benedikt Kirchner, Bettina Haase, Michael Pfaffl, Ari Waisman, Richard A Willis, Anette-G Ziegler, Carolin Daniel
Aberrant immune activation mediated by T effector cell populations is pivotal in the onset of autoimmunity in type 1 diabetes (T1D). T follicular helper (TFH) cells are essential in the induction of high-affinity antibodies, and their precursor memory compartment circulates in the blood. The role of TFH precursors in the onset of islet autoimmunity and signaling pathways regulating their differentiation is incompletely understood. Here, we provide direct evidence that during onset of islet autoimmunity, the insulin-specific target T-cell population is enriched with a C-X-C chemokine receptor type 5 (CXCR5)(+)CD4(+) TFH precursor phenotype...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27768364/-7-be-n-%C3%AE-4-he-reaction-and-the-cosmological-lithium-problem-measurement-of-the-cross-section-in-a-wide-energy-range-at-n_tof-at-cern
#15
M Barbagallo, A Musumarra, L Cosentino, E Maugeri, S Heinitz, A Mengoni, R Dressler, D Schumann, F Käppeler, N Colonna, P Finocchiaro, M Ayranov, L Damone, N Kivel, O Aberle, S Altstadt, J Andrzejewski, L Audouin, M Bacak, J Balibrea-Correa, S Barros, V Bécares, F Bečvář, C Beinrucker, E Berthoumieux, J Billowes, D Bosnar, M Brugger, M Caamaño, M Calviani, F Calviño, D Cano-Ott, R Cardella, A Casanovas, D M Castelluccio, F Cerutti, Y H Chen, E Chiaveri, G Cortés, M A Cortés-Giraldo, S Cristallo, M Diakaki, C Domingo-Pardo, E Dupont, I Duran, B Fernandez-Dominguez, A Ferrari, P Ferreira, W Furman, S Ganesan, A García-Rios, A Gawlik, T Glodariu, K Göbel, I F Gonçalves, E González-Romero, E Griesmayer, C Guerrero, F Gunsing, H Harada, T Heftrich, J Heyse, D G Jenkins, E Jericha, T Katabuchi, P Kavrigin, A Kimura, M Kokkoris, M Krtička, E Leal-Cidoncha, J Lerendegui, C Lederer, H Leeb, S Lo Meo, S J Lonsdale, R Losito, D Macina, J Marganiec, T Martínez, C Massimi, P Mastinu, M Mastromarco, A Mazzone, E Mendoza, P M Milazzo, F Mingrone, M Mirea, S Montesano, R Nolte, A Oprea, A Pappalardo, N Patronis, A Pavlik, J Perkowski, M Piscopo, A Plompen, I Porras, J Praena, J Quesada, K Rajeev, T Rauscher, R Reifarth, A Riego-Perez, P Rout, C Rubbia, J Ryan, M Sabate-Gilarte, A Saxena, P Schillebeeckx, S Schmidt, P Sedyshev, A G Smith, A Stamatopoulos, G Tagliente, J L Tain, A Tarifeño-Saldivia, L Tassan-Got, A Tsinganis, S Valenta, G Vannini, V Variale, P Vaz, A Ventura, V Vlachoudis, R Vlastou, J Vollaire, A Wallner, S Warren, M Weigand, C Weiß, C Wolf, P J Woods, T Wright, P Žugec
The energy-dependent cross section of the ^{7}Be(n,α)^{4}He reaction, of interest for the so-called cosmological lithium problem in big bang nucleosynthesis, has been measured for the first time from 10 meV to 10 keV neutron energy. The challenges posed by the short half-life of ^{7}Be and by the low reaction cross section have been overcome at n_TOF thanks to an unprecedented combination of the extremely high luminosity and good resolution of the neutron beam in the new experimental area (EAR2) of the n_TOF facility at CERN, the availability of a sufficient amount of chemically pure ^{7}Be, and a specifically designed experimental setup...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27746950/crystal-structures-of-di-aquadi-%C3%AE-hydroxido-tris-tri-methyl-tin-iv-diformatotri-methyl-stannate-iv-and-di-%C3%AE-hydroxido-tris-tri-methyl-tin-iv-chloride-monohydrate
#16
Felix Otte, Stephan G Koller, Christopher Golz, Carsten Strohmann
The title compounds, [Sn3(CH3)9(OH)2(H2O)2][Sn(CH3)3(CHO2)2] (1) and [Sn3(CH3)9(OH)2]Cl·H2O (2), are partially condensed products of hydrolysed tri-methyl-tin chloride. In the structures of 1 and 2, short cationic tris-tannatoxanes (C9H29O2Sn3) are bridged by a diformatotri-methyl-tin anion or a chloride anion, respectively. Hydrogen bridges are present and supposedly stabilize these structures against further polymerization to the known polymeric tri-methyl-tin hydroxide. Especially noteworthy is that the formate present in this structure was formed from atmospheric CO2...
October 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27715117/insight-into-the-narrow-structure-in-%C3%AE-photoproduction-on-the-neutron-from-helicity-dependent-cross-sections
#17
L Witthauer, M Dieterle, S Abt, P Achenbach, F Afzal, Z Ahmed, J R M Annand, H J Arends, M Bashkanov, R Beck, M Biroth, N S Borisov, A Braghieri, W J Briscoe, F Cividini, S Costanza, C Collicott, A Denig, E J Downie, P Drexler, M I Ferretti-Bondy, S Gardner, S Garni, D I Glazier, D Glowa, W Gradl, M Günther, G M Gurevich, D Hamilton, D Hornidge, G M Huber, A Käser, V L Kashevarov, S Kay, I Keshelashvili, R Kondratiev, M Korolija, B Krusche, A B Lazarev, J M Linturi, V Lisin, K Livingston, S Lutterer, I J D MacGregor, J Mancell, D M Manley, P P Martel, V Metag, W Meyer, R Miskimen, E Mornacchi, A Mushkarenkov, A B Neganov, A Neiser, M Oberle, M Ostrick, P B Otte, D Paudyal, P Pedroni, A Polonski, S N Prakhov, A Rajabi, G Reicherz, G Ron, T Rostomyan, A Sarty, C Sfienti, M H Sikora, V Sokhoyan, K Spieker, O Steffen, I I Strakovski, Th Strub, I Supek, A Thiel, M Thiel, A Thomas, M Unverzagt, Yu A Usov, S Wagner, N K Walford, D P Watts, D Werthmüller, J Wettig, M Wolfes, L Zana
The double polarization observable E and the helicity dependent cross sections σ_{1/2} and σ_{3/2} were measured for η photoproduction from quasifree protons and neutrons. The circularly polarized tagged photon beam of the A2 experiment at the Mainz MAMI accelerator was used in combination with a longitudinally polarized deuterated butanol target. The almost 4π detector setup of the Crystal Ball and TAPS is ideally suited to detect the recoil nucleons and the decay photons from η→2γ and η→3π^{0}...
September 23, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27713560/efficient-enrichment-of-bacterial-mrna-from-host-bacteria-total-rna-samples
#18
Nikhil Kumar, Mingqun Lin, Xuechu Zhao, Sandra Ott, Ivette Santana-Cruz, Sean Daugherty, Yasuko Rikihisa, Lisa Sadzewicz, Luke J Tallon, Claire M Fraser, Julie C Dunning Hotopp
Despite numerous advances in genomics and bioinformatics, technological hurdles remain to examine host-microbe transcriptomics. Sometimes the transcriptome of either or both can be ascertained merely by generating more sequencing reads. However, many cases exist where bacterial mRNA needs to be enriched further to enable cost-effective sequencing of the pathogen or endosymbiont. While a suitable method is commercially available for mammalian samples of this type, development of such methods has languished for invertebrate samples...
October 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27701255/a-new-species-of-the-genus-apollophanes-o-pickard-cambridge-1898-araneae-philodromidae-with-the-first-record-to-the-atlantic-rainforest
#19
Rafael Carlo Francisco, Ricardo Ott, Renato Augusto Teixeira
Apollophanes has a wide distribution, with some species in Asia and most of the species recorded from North and Central America (World Spider Catalog 2016). New species described from the Galapagos Islands by Baert (2013) have extended the genus range to South America. According to Dondale and Redner (1975) and Dondale and Redner (1978), the species of Apollophanes have a moderately low prosoma, usually of yellow to orange-brown color and with black or brown spots on the lateral margins. The posterior eyes distances are equally spaced and the legs are long, slender and speckled with dark spots, with leg I usually being longer than IV (characteristic observed only in the male exemplar of the new species)...
September 26, 2016: Zootaxa
https://www.readbyqxmd.com/read/27698117/regulation-of-mir165-166-by-class-ii-and-class-iii-homeodomain-leucine-zipper-proteins-establishes-leaf-polarity
#20
Paz Merelo, Hathi Ram, Monica Pia Caggiano, Carolyn Ohno, Felix Ott, Daniel Straub, Moritz Graeff, Seok Keun Cho, Seong Wook Yang, Stephan Wenkel, Marcus G Heisler
A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial-abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown...
October 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
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