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chemotherapy hyperthermia

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https://www.readbyqxmd.com/read/29777957/dual-ph-reduction-responsive-hybrid-polymeric-micelles-for-targeted-chemo-photothermal-combination-therapy
#1
Linhua Zhang, Yu Qin, Zhiming Zhang, Fan Fan, Chenlu Huang, Li Lu, Hai Wang, Xu Jin, Hanxue Zhao, Deling Kong, Chun Wang, Hongfan Sun, Xigang Leng, Dunwan Zhu
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs exhibited nano-sized structure (∼100 nm) with good monodispersity, high encapsulation efficiency of both ICG and DOX, triggered DOX release in response to acid pH and reduction environment, and excellent temperature conversion with laser irradiation...
May 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29763773/ultrasound-doppler-as-an-imaging-modality-for-selection-of-murine-4t1-breast-tumors-for-combination-radiofrequency-hyperthermia-and-chemotherapy
#2
Martyna Krzykawska-Serda, Jason Chak-Shing Ho, Matthew J Ware, Justin J Law, Jared M Newton, Lam Nguyen, Mahdi Agha, Steven A Curley, Stuart J Corr
Noninvasive radiofrequency-induced (RF) hyperthermia has been shown to increase the perfusion of chemotherapeutics and nanomaterials through cancer tissue in ectopic and orthotopic murine tumor models. Additionally, mild hyperthermia (37°C-45°C) has previously shown a synergistic anticancer effect when used with standard-of-care chemotherapeutics such as gemcitabine and Abraxane. However, RF hyperthermia treatment schedules remain unoptimized, and the mechanisms of action of hyperthermia and how they change when treating various tumor phenotypes are poorly understood...
May 11, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29752115/core-shell-structure-of-fe-3-o-4-mtx-ldh-au-nps-for-cancer-therapy
#3
Xiu-Fen Zhao, Wei-Yuan Wang, Xiao-Dong Li, Shu-Ping Li, Fu-Gui Song
Nearly monodispersed magnetic Fe3 O4 @MTX-LDH/Au nanoparticles (NPs) containing the anticancer agent of methotrexate (MTX) were prepared via a coprecipitation-electrostatic interaction strategy. Firstly, layered double hydroxide (LDH) materials were deposited over the surface of Fe3 O4 NPs by the coprecipitation method. Secondly, Au NPs were successfully conjugated onto the surface of LDH through electrostatic interaction. Herein, MTX was used both as the agent for surface modification and the anticancer drug for chemotherapy...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752021/hyperthermic-treatment-at-56-%C3%A2-c-induces-tumour-specific-immune-protection-in-a-mouse-model-of-prostate-cancer-in-both-prophylactic-and-therapeutic-immunization-regimens
#4
Francesco De Sanctis, Sara Sandri, Matteo Martini, Marta Mazzocco, Alessandra Fiore, Rosalinda Trovato, Stefano Garetto, Davide Brusa, Stefano Ugel, Silvia Sartoris
Most active cancer immunotherapies able to induce a long-lasting protection against tumours are based on the activation of tumour-specific cytotoxic T lymphocytes (CTLs). Cell death by hyperthermia induces apoptosis followed by secondary necrosis, with the production of factors named "danger associated molecular pattern" (DAMP) molecules (DAMPs), that activate dendritic cells (DCs) to perform antigen uptake, processing and presentation, followed by CTLs cross priming. In many published studies, hyperthermia treatment of tumour cells is performed at 42-45 °C; these temperatures mainly promote cell surface expression of DAMPs...
May 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29745932/analysis-of-tolerance-and-security-of-chemo-hyperthermia-with-mitomycin-c-for-the-treatment-of-non-muscle-invasive-bladder-cancer
#5
Juan León-Mata, José Luis Domínguez, Joan Palou Redorta, Daniel Sousa González, María Alvarez Casal, Alejandro Sousa Escandón, Eva Piñeiro Vázquez
OBJECTIVES: The treatment of non muscle invasive bladder cancer (NMIBC) continues to be a challenge. Hyperthermia (HT) combined with intravesical chemotherapy is used to enhance the effects of chemotherapy. METHODS: A review of the publications was carried out to synthesize the adverse effects (AE) reported by the use of chemohyperthermia (QHT) with Mitomycin-C (MMC). The most relevant data are exposed for each of the devices currently used in the QHT. RESULTS: SYNERGO®: The dropout rate varied between 3-40%, and the AE rate is up to 88%...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745931/-mitomycin-c-hivec-update-and-results-in-high-risk-patients
#6
Félix Guerrero-Ramos, Daniel Castellano-Gauna, Esther García-Rojo, José Manuel Duarte-Ojeda, Federico de la Rosa-Kehrmann, Felipe Villacampa-Aubá
Adjuvant endovesical treatment is a research field in constant exploration with the aim to minimize the risk of recurrence and progression of non muscle invasive bladder tumors. Over the last years, the administration of chemotherapy in a chemo hyperthermia regimen has been added to the existing regimens. There are various systems for its administration, but this article focus on HIVEC (Hyperthermic IntraVEsical Chemotherapy) and its current status. In this review article we update the results of this system in the case-scenarios it has been used (preoperative with ablative intention and as adjuvant therapy with prophylactic purposes), tolerance and security issues, on-going clinical trials and future perspectives...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745929/-chemohyperthermia-using-mmc-in-non-muscle-invasive-bladder-cancer-current-status-and-future-perspectives
#7
Jacqueline J M J H Coenen, F Johannes P van Valenberg, Tom J H Arends, J Alfred Witjes
In an effort to decrease recurrence and progression rates in non-muscle-invasive bladder cancer (NMIBC), transurethral resection of a bladder tumor is followed by intravesical instillations using Mitomycin-C (MMC) and Bacillus Calmette-Guérin (BCG). In spite of these adjuvant treatment modalities, recurrence and progression rates remain high. Because of these limitations of current standard therapy and the shortage of BCG, there is a search for alternative forms of treatment in NMIBC. Intravesical MMC combined with hyperthermia, especially RF-induced QHT being most extensively investigated in the past 20 years, is one of these alternatives for intermediate- and high-risk NMIBC...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745922/-bcg-and-bladder-cancer-past-present-and-future
#8
Álvaro Sánchez González, Oscar Rodríguez Faba, Lucía Mosquera, Laia Sabiote, Alberto Breda, Joan Palou Redorta
BCG has been used in the treatment of NMIBC for more than 40 years. Nevertheless, its exact working mechanisms have not been completely discovered. Clinical and basic research done over all these years has generated much information but it could be summarized in a few simple statements. It has been demonstrated the best route of administration is intravesical, BCG is superior than intracavitary chemotherapy to prevent recurrence but its adverse events are worse. Recently, it has been demonstrated that BCG could delay or prevent progression to infiltrative cancer...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29743489/magnetic-mesoporous-calcium-sillicate-chitosan-porous-scaffolds-for-enhanced-bone-regeneration-and-photothermal-chemotherapy-of-osteosarcoma
#9
Fan Yang, Jiawei Lu, Qinfei Ke, Xiaoyuan Peng, Yaping Guo, Xuetao Xie
The development of multifunctional biomaterials to repair bone defects after neoplasm removal and inhibit tumor recurrence remained huge clinical challenges. Here, we demonstrate a kind of innovative and multifunctional magnetic mesoporous calcium sillicate/chitosan (MCSC) porous scaffolds, made of M-type ferrite particles (SrFe12 O19 ), mesoporous calcium silicate (CaSiO3 ) and chitosan (CS), which exert robust anti-tumor and bone regeneration properties. The mesopores in the CaSiO3 microspheres contributed to the drug delivery property, and the SrFe12 O19 particles improved photothermal therapy (PTT) conversion efficacy...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29733199/nanosystems-based-on-magnetic-nanoparticles-and-thermo-or-ph-responsive-polymers-an-update-and-future-perspectives
#10
Binh T Mai, Soraia Fernandes, Preethi B Balakrishnan, Teresa Pellegrino
Combining hard matter, like inorganic nanocrystals, and soft materials, like polymers, can generate multipurpose materials with a broader range of applications with respect to the individual building blocks. Given their unique properties at the nanoscale, magnetic nanoparticles (MNPs) have drawn a great deal of interest due to their potential use in the biomedical field, targeting several applications such as heat hubs in magnetic hyperthermia (MHT, a heat-damage based therapy), contrast agents in magnetic resonance imaging (MRI), and nanocarriers for targeted drug delivery...
May 7, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29723626/doxorubicin-hydrochloride-loaded-electrospun-chitosan-cobalt-ferrite-titanium-oxide-nanofibers-for-hyperthermic-tumor-cell-treatment-and-controlled-drug-release
#11
Maryam Radmansouri, Ehsan Bahmani, Einollah Sarikhani, Keivan Rahmani, Fariborz Sharifianjazi, Mohammad Irani
In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample magnetometer (VSM) analysis...
April 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29715088/application-of-albumin-embedded-magnetic-nanoheaters-for-release-of-etoposide-in-integrated-chemotherapy-and-hyperthermia-of-u87-mg-glioma-cells
#12
Melánia Babincová, Hana Vrbovská, Paul Sourivong, Peter Babinec, Štefan Durdík
BACKGROUND/AIM: Malignant gliomas remain refractory to several therapeutic approaches and the requirement for novel treatment modalities is critical to combat this disease. Etoposide is a topoisomerase-II inhibitor, which promotes DNA damage and apoptosis of cancer cells. In this study, we prepared albumin with embedded magnetic nanoparticles and etoposide for in vitro evaluation of combined hyperthermia and chemotherapy. MATERIAL AND METHODS: Magnetic nanoparticles were prepared by a modified co-precipitation method in the presence of human serum albumin and etoposide...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29697100/the-comparative-effect-of-wrapping-solid-gold-nanoparticles-and-hollow-gold-nanoparticles-with-doxorubicin-loaded-thermosensitive-liposomes-for-cancer-thermo-chemotherapy
#13
Yanan Li, Dongsheng He, Jiasheng Tu, Ru Wang, Chang Zu, You Chen, Wenqian Yang, Di Shi, Thomas J Webster, Yan Shen
Since conventional chemotherapy is a systemic treatment that affects the body globally and will not concentrate inside the tumor, it causes adverse side effects to patients. In this study, doxorubicin (DOX) together with solid gold nanoparticles (GNPs) or hollow gold nanoparticles (HGNPs), respectively, is loaded inside thermosensitive liposomes (GNPs&DOX-TLs and HGNPs&DOX-TLs), where the GNPs and HGNPs act as a "nanoswitch" for killing tumor cells directly by hyperthermia and triggering DOX release from TLs in the tumor quickly by near infrared laser (NIR) illumination...
April 26, 2018: Nanoscale
https://www.readbyqxmd.com/read/29676175/epigenetic-agents-in-combined-anticancer-therapy
#14
Zdeněk Kejík, Milan Jakubek, Robert Kaplánek, Jarmila Králová, Ivan Mikula, Pavel Martásek, Vladimír Král
In the last decade, epigenetic drugs (such as inhibitors of DNA methyltransferases and histone deacetylases) have been intensively used for cancer treatment. Their applications have shown high anticancer effectivity and tolerable side effects. However, they are unfortunately not effective in the treatment of some types and phenotypes of cancers. Nevertheless, several studies have demonstrated that problems of drug efficacy can be overcome through the combined application of therapeutic modulates. Therefore, combined applications of epigenetic agents with chemotherapy, radiation therapy, immunotherapy, oncolytic virotherapy and hyperthermia have been presented...
April 20, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29673642/hyperthermia-mediated-drug-delivery-induces-biological-effects-at-the-tumor-and-molecular-levels-that-improve-cisplatin-efficacy-in-triple-negative-breast-cancer
#15
Michael Dunne, Yannan N Dou, Danielle M Drake, Tara Spence, Sávio M L Gontijo, Peter G Wells, Christine Allen
Triple negative breast cancer is an aggressive disease that accounts for at least 15% of breast cancer diagnoses, and a disproportionately high percentage of breast cancer related morbidity. Intensive research efforts are focused on the development of more efficacious treatments for this disease, for which therapeutic options remain limited. The high incidence of mutations in key DNA repair pathways in triple negative breast cancer results in increased sensitivity to DNA damaging agents, such as platinum-based chemotherapies...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29663543/surface-nanopore-engineering-of-2d-mxenes-for-targeted-and-synergistic-multitherapies-of-hepatocellular-carcinoma
#16
Zhenli Li, Han Zhang, Jun Han, Yu Chen, Han Lin, Tian Yang
Hepatocellular carcinoma (HCC) is one of the most common and deadly gastrointestinal malignancies. Given its insensitivity to traditional systematic chemotherapy, new therapeutic strategies for efficient HCCs treatment are urgently needed. Here, the development of a novel 2D MXene-based composite nanoplatform for highly efficient and synergistic chemotherapy and photothermal hyperthermia against HCC is reported. A surface-nanopore engineering strategy is developed for the MXenes' surface functionalization, which achieves the uniform coating of a thin mesoporous-silica layer onto the surface of 2D Ti3 C2 MXene (Ti3 C2 @mMSNs)...
April 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29659611/preoperative-evaluation-of-the-efficacy-of-radio-hyperthermo-chemotherapy-for-soft-tissue-sarcoma-in-a-case-series
#17
Hisaki Aiba, Satoshi Yamada, Jun Mizutani, Norio Yamamoto, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Yoshihiro Araki, Hiroyuki Tsuchiya, Takanobu Otsuka
PURPOSE: Radio-hyperthermo-chemo (RHC) therapy, which combines radiotherapy, hyperthermia, and chemotherapy, for malignant soft tissue tumors has been introduced with the aim of decreasing the possibility of local recurrence after surgery. To avoid unnecessary neoadjuvant therapy and to plan the appropriate surgical treatment, surveillance of RHC therapeutic efficacy during treatment is necessary. In this study, we determined the optimal response criteria to evaluate the efficacy of RHC by comparing preoperative images before and after RHC with pathological evaluation of necrosis in the resected tumor...
2018: PloS One
https://www.readbyqxmd.com/read/29626787/enzyme-triggered-size-shrink-and-laser-enhanced-no-release-nanoparticles-for-deep-tumor-penetration-and-combination-therapy
#18
Chuan Hu, Xingli Cun, Shaobo Ruan, Rui Liu, Wei Xiao, Xiaotong Yang, Yuanyuan Yang, Chuanyao Yang, Huile Gao
Chemotherapy remains restricted by poor drug delivery efficacy due to the heterogenous nature of tumor. Herein, we presented a novel nanoparticle that could not only response to the tumor microenvironment but also modulate it for deep tumor penetration and combination therapy. The intelligent nanoparticle (IDDHN) was engineered by hyaluronidase (HAase)-triggered size shrinkable hyaluronic acid shells, which were modified with NIR laser sensitive nitric oxide donor (HN), small-sized dendrimeric prodrug (IDD) of doxorubicin (DOX) as chemotherapy agent and indocyanine green (ICG) as photothermal agent into a single nanoparticle...
March 27, 2018: Biomaterials
https://www.readbyqxmd.com/read/29626594/population-pharmacokinetics-of-oxaliplatin-after-intraperitoneal-administration-with-hyperthermia-in-wistar-rats
#19
M I Mas-Fuster, A Ramon-Lopez, F J Lacueva, A Arroyo, P Más-Serrano, R Nalda-Molina
BACKGROUND: The evaluation of the efficacy and toxicity of hyperthermic intraoperative peritoneal chemotherapy presents some difficulties, due in part to the lack of information about the pharmacokinetic behavior of the drugs administered in this procedure. The aim of this study was to characterize the population pharmacokinetics of hyperthermic intraoperative peritoneal oxaliplatin in Wistar rats and to evaluate the effect of treatment-related covariates dose, instillation time and temperature on the pharmacokinetic parameters...
April 4, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29623854/cytotoxic-effect-of-5-fluorouracil-loaded-polymer-coated-magnetite-nanographene-oxide-combined-with-radiofrequency
#20
Leili Asadi, Sakine Shirvalilou, Sepideh Khoee, Samideh Khoei
Despite the development of conventional therapies, include surgery, radiotherapy, chemotherapy and hyperthermia, the prognosis remains very poor. Recently, integration of conventional therapy and multifunctional nanoparticles have attracted a lot of attention because it produces a synergistic effect and better diagnostic and therapeutic efficiency. OBJECTIVE: This study aimed to investigate the uptake and cytotoxic effects of polycaprolactone (PCL)/chitosan (CHI)-coated superparamagnetic iron oxide nano-graphene oxide (SPION-NGO) as a carrier of 5-fluorouracil (5-Fu) and radiofrequency (RF) hyperthermia using an alternate magnetic field (AMF) with 13...
April 4, 2018: Anti-cancer Agents in Medicinal Chemistry
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