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chemotherapy hyperthermia

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https://www.readbyqxmd.com/read/28625619/intra-thoracic-chemo-hyperthermia-for-pleural-recurrence-of-thymoma
#1
Jean Michel Maury, Nicolas Girard, Mayeul Tabutin, Renaud Grima, Lara Chalabreysse, Isabelle Pavlakovic, Annie Sayag-Beaujard, Caroline Leroux, Pierre-Jean Souquet, Olivier Glehen, François Tronc
BACKGROUND: Pleural recurrences are a hallmark of thymomas, and represent a challenge for multidisciplinary management. The purpose of this study was to assess the feasibility and the results in terms of morbidity, mortality and survival rates, of Intra-Thoracic Chemo-Hyperthermia (ITCH) for the treatment of pleural recurrences of thymomas. METHODS: Retrospective analysis of 19 consecutives patients between 1997 and 2015 treated by surgical cytoreduction (pleurectomy) followed by ITCH with 25mg/m(2) of mitomycin, and 50mg/m(2) of Cisplatin...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28592133/concurrent-hyperthermia-and-re-irradiation-for-recurrent-high-grade-gliomas
#2
J Heo, S H Kim, Y T Oh, M Chun, O K Noh
Salvage therapy for recurrent high grade gliomas (HGG) includes surgery, radiotherapy and chemotherapy, however, standard treatment does not exist. We evaluated the tolerability and efficacy of re-irradiation (re-RT) with hyperthermia (HT) for patients with recurrent HGG. From September 2010 to July 2015, 20 patients with recurrent HGG were treated with re-RT and HT. The radiotherapy dose of 30 Gray (Gy) was delivered with 2 Gy per fraction daily, and HT was performed twice weekly. Primary endpoints were treatment compliance and toxicity...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28588736/treatment-outcomes-of-concurrent-hyperthermia-and-chemoradiotherapy-for-pancreatic-cancer-insights-into-the-significance-of-hyperthermia-treatment
#3
Toshiya Maebayashi, Naoya Ishibashi, Takuya Aizawa, Masakuni Sakaguchi, Tsutomu Sato, Jiro Kawamori, Yoshiaki Tanaka
Patients with locally advanced unresectable pancreatic cancer (LAUPC) have a poor prognosis. In addition their quality of life impaired by cancer pain and biliary tract infections. Therefore, multimodality therapy and selection of optimal treatment methods are essential for achieving prolonged survival. The present study investigated the significance of using hyperthermia concurrently with multimodality therapy to improve treatment outcomes in patients with LAUPC. In total, 13 patients receiving concurrent hyperthermia and chemoradiotherapy (HCR) or chemoradiotherapy (CR) alone for LAUPC between 2002 and 2013 were analyzed retrospectively...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28557569/the-global-end-diastolic-volume-gedv-could-be-more-appropiate-to-fluid-management-than-central-venous-pressure-cvp-during-closed-hyperthermic-intrabdominal-chemotherapy-with-co2-circulation
#4
Francisco Javier Redondo, David Padilla, Pedro Villarejo, Victor Baladron, Patricia Faba, Sergio Sánchez, José Ramón Muñoz-Rodríguez, Natalia Bejarano
BACKGROUND: Closed hyperthermic intraperitoneal chemotherapy (HIPEC) may increase abdominal pressure and effects of hemodynamic changes due to maintenance hyperthermia. Our aim was to analyze the safety and effectiveness of our closed technique with CO2 circulation in management fluid status and hemodynamic parameters by means of cardiac preload control measured by Global End Diastolic Values (GEDV) and a gas exchanger. MATERIAL AND METHODS: A Pilot Clinical Study that included 18 advanced ovarian cancer patients undergoing citoreductive surgery and HIPEC...
May 30, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28553112/ionp-doped-nanoparticles-for-highly-effective-nir-controlled-drug-release-and-combination-tumor-therapy
#5
Xudong Fu, Xinjun Wang, Shaolong Zhou, Yanyan Zhang
Despite advances in controlled drug delivery, drug delivery systems (DDSs) with controlled activated drug release and high spatial and temporal resolution are still required. Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. In this study, a near-infrared light-controlled "off-on" DDS with magnetic resonance imaging and magnetic targeting properties was developed using a hybrid nanoplatform (carbon nanotubes [CNTs]-iron oxide nanoparticle)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28540819/a-remote-temperature-sensor-for-an-ultrasound-hyperthermia-system-using-the-acoustic-signal-derived-from-the-heating-signals
#6
Dibbyan Mazumder, Ram Mohan Vasu, Debasish Roy, Rajan Kanhirodan
We demonstrate a non-invasive technique, based on the modal frequency shift of a region insonified by a dual-beam ultrasound (US) transducer (region of interest, ROI), to remotely assess the temperature of the region in a tissue-mimicking object. The application is in ultrasound hyperthermia systems for controlled maintenance of tumour temperature during chemotherapy. Towards this, we have characterised the variation of the storage modulus with the temperature of two tissue-mimicking visco-elastic materials...
May 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28538407/unusual-jaw-metastasis-from-squamous-cell-lung-cancer-in-heavy-smoker-two-case-reports-and-review-of-the-literature
#7
Aldo Pezzuto, Michelangelo Morrone, Elidon Mici
RATIONALE: Jaw metastasis is a very rare condition associated with lung cancer evolution. In this paper we present two cases of patients who underwent different approach.Lung cancer is the leading cause of cancer related death worldwide. Survival depends on the staging and biology of tumor. Smoking may affect the prognosis. PATIENT CONCERNS: There are herein reported the cases of two patients affected by squamous cell lung cancer with spread to mandibular bone. DIAGNOSES: In the first case a computed tomography (CT scan) showed a large mass located in upper right lung , then bronchoscopy was performed with biopsies and the histology revealed a squamous cell carcinoma P63+ and TTF-...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28535418/a-study-of-peritoneal-metastatic-xenograft-model-of-colorectal-cancer-in-the-treatment-of-hyperthermic-intraperitoneal-chemotherapy-with-raltitrexed
#8
Cen Qiu, Yueqi Li, Xin Liang, Yingxue Qi, Yiyang Chen, Xianke Meng, Hongtu Zheng, Ye Xu, Sanjun Cai, Guoxiang Cai, Jianwen Liu
Peritoneal metastasis of colorectal cancer is one of the most incident and fateful diseases among relapse cases. It shows a certain resistance to systemic chemotherapy. The perfusion system in clinic is complex and hard to be used in fundamental researches. This study aims at evaluating the effect of an improved hyperthermic intraperitoneal chemotherapy with Raltitrexed used in tumor-bearing mice with peritoneal metastatic colorectal carcinoma. The results showed that no severe adverse effect was observed. All control animals developed extensive peritoneal and mesenteric metastatic nodes...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28534018/hyperthermic-intrathoracic-chemotherapy-with-cisplatin-for-ovarian-cancer-with-pleural-metastasis
#9
Su Youn Jun, Yang Ki Seok, Tomoyasu Kato, Da Som Chun, Yoon Hee Lee, Gun Oh Chong, Yoon Soon Lee, Young Lae Cho, Dae Gy Hong
Intrathoracic metastasis of ovarian cancer has poor prognosis regardless of treatment modality. Recent development of surgical techniques and the new concept of direct infusion of chemotherapeutic agents with hyperthermia could help with the treatment of disseminated diseases in ovarian cancer. Using video-assisted thoracoscopic surgery and intracavitary chemotherapy with hyperthermia, we tried hyperthermic intrathoracic chemotherapy for a case of stage IV high-grade serous ovarian cancer with pleural metastasis...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28525950/hydrophobic-drug-loaded-pegylated-magnetic-liposomes-for-drug-controlled-release
#10
Andri Hardiansyah, Ming-Chien Yang, Ting-Yu Liu, Chih-Yu Kuo, Li-Ying Huang, Tzu-Yi Chan
Less targeted and limited solubility of hydrophobic-based drug are one of the serious obstacles in drug delivery system. Thus, new strategies to enhance the solubility of hydrophobic drug and controlled release behaviors would be developed. Herein, curcumin, a model of hydrophobic drug, has been loaded into PEGylated magnetic liposomes as a drug carrier platform for drug controlled release system. Inductive magnetic heating (hyperthermia)-stimulated drug release, in vitro cellular cytotoxicity assay of curcumin-loaded PEGylated magnetic liposomes and cellular internalization-induced by magnetic guidance would be investigated...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28521752/synthesis-characterization-and-biological-verification-of-anti-her2-indocyanine-green-doxorubicin-loaded-polyethyleneimine-coated-perfluorocarbon-double-nanoemulsions-for-targeted-photochemotherapy-of-breast-cancer-cells
#11
Yu-Hsiang Lee, Yun-Ting Ma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer is known to be more aggressive and often resistant to medicinal treatment, leading to an insufficient prognosis and poor susceptibility to chemotherapy and/or hormonal therapy in the current clinic. These circumstances implicate that developing an improved therapeutic strategy rather than persistently changing the anticancer drugs for trying is truly needed to successfully cure this type of breast cancer...
May 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28513646/biocompatibility-and-therapeutic-evaluation-of-magnetic-liposomes-designed-for-self-controlled-cancer-hyperthermia-and-chemotherapy
#12
Manashjit Gogoi, Manish K Jaiswal, Haladhar Dev Sarma, Dhirendra Bahadur, Rinti Banerjee
Magnetic liposome-mediated combined chemotherapy and hyperthermia is gaining importance as an effective therapeutic modality for cancer. However, control and maintenance of optimum hyperthermia are major challenges in clinical settings due to the overheating of tissues. To overcome this problem, we developed a novel magnetic liposomes formulation co-entrapping a dextran coated biphasic suspension of La0.75Sr0.25MnO3 (LSMO) and iron oxide (Fe3O4) nanoparticles for self-controlled hyperthermia and chemotherapy...
May 17, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28472102/injectable-plga-fe3o4-implants-carrying-cisplatin-for-synergistic-magnetic-hyperthermal-ablation-of-rabbit-vx2-tumor
#13
Yang Yang, Fengjuan Wang, Kaiyuan Zheng, Liming Deng, Lu Yang, Nan Zhang, Chunyan Xu, Haitao Ran, Zhaoxia Wang, Zhigang Wang, Yuanyi Zheng
Magnetic hyperthermia ablation has attracted wide attention in tumor therapy for its minimal invasion. Although the chemo-hyperthermal synergism has been proven to be effective in subcutaneously xenografted tumors of nude mice in our previous experiment, the occurrence of residual tumors due to incomplete ablation is more common in relatively larger and deeper-seated tumors in anti-tumor therapy. Thus, a larger tumor and larger animal model are needed for further study of the therapeutic efficacy. In this study, we tested the efficiency of this newly developed technique using a rabbit tumor model...
2017: PloS One
https://www.readbyqxmd.com/read/28450782/gold-nanorod-based-poly-lactic-co-glycolic-acid-with-manganese-dioxide-core-shell-structured-multifunctional-nanoplatform-for-cancer-theranostic-applications
#14
Lei Wang, Dong Li, Yongwei Hao, Mengya Niu, Yujie Hu, Hongjuan Zhao, Junbiao Chang, Zhenzhong Zhang, Yun Zhang
Recently, photothermal therapy has become a promising strategy in tumor treatment. However, the therapeutic effect was seriously hampered by the low tissue penetration of laser. Therefore, in this study, radiofrequency (RF) with better tissue penetration was used for tumor hyperthermia. First, one type of gold nanorods (AuNRs) suitable for RF hyperthermia was selected. Then, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with AuNRs and docetaxel (DTX) (PLGA/AuNR/DTX) NPs were constructed. Finally, manganese dioxide (MnO2) ultrathin nanofilms were coated on the surfaces of PLGA/AuNR/DTX NPs by the reduction of KMnO4 to construct the PLGA/AuNR/DTX@MnO2 drug delivery system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28449703/a-short-time-interval-between-radiotherapy-and-hyperthermia-reduces-in-field-recurrence-and-mortality-in-women-with-advanced-cervical-cancer
#15
Caspar M van Leeuwen, Arlene L Oei, Kenneth W T K Chin, Johannes Crezee, Arjan Bel, Anneke M Westermann, Marrije R Buist, Nicolaas A P Franken, Lukas J A Stalpers, H Petra Kok
BACKGROUND: Combined radiotherapy and hyperthermia is a well-established alternative to chemoradiotherapy for advanced stage cervical cancer patients with a contraindication for chemotherapy. Pre-clinical evidence suggests that the radiosensitizing effect of hyperthermia decreases substantially for time intervals between radiotherapy and hyperthermia as short as 1-2 h, but clinical evidence is limited. The purpose of this study is to determine the effect of the time interval between external beam radiotherapy (EBRT) and same-day hyperthermia on in-field recurrence rate, overall survival and late toxicity in women with advanced stage cervical cancer...
April 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28448900/dual-responsive-magnetic-composite-nanogels-for-thermo-chemotherapy
#16
S Indulekha, P Arunkumar, D Bahadur, R Srivastava
With the onset of hyperthermia and their advantage in increasing vascular perfusion and permeability in the cancer milieu, thermo-responsive polymers have become an attractive candidate for designing therapeutic nano-vehicles for targeted on-demand delivery of bioactive agents. For this purpose, we developed a dual (thermo- and pH-) responsive nanotherapeutic composite system rendering a combinational therapy of hyperthermia mediated drug delivery. This composite system comprises of magnetic chitosan-g-PNVCL (MCP) polymeric nanogels loaded with anticancer drug, Doxorubicin (DOX)...
April 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28429764/fabrication-characterization-and-biological-evaluation-of-anti-her2-indocyanine-green-doxorubicin-encapsulated-peg-b-plga-copolymeric-nanoparticles-for-targeted-photochemotherapy-of-breast-cancer-cells
#17
Yu-Hsiang Lee, Da-Sheng Chang
In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. The HIDPPNPs were fabricated using a solvent evaporation technique followed by carbodiimide-mediated antibody conjugation on the nanoparticle surface...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417560/treatment-of-tumor-in-lymph-nodes-using-near-infrared-laser-light-activated-thermosensitive-liposome-encapsulated-doxorubicin-and-gold-nanorods
#18
Daisuke Matsuki, Oladipo Adewale, Sachiko Horie, Junnosuke Okajima, Atsuki Komiya, Oluwatobi Oluwafemi, Shigenao Maruyama, Shiro Mori, Tetsuya Kodama
Tumor metastasis to lymph nodes is an important contributory factor for cancer-related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX-TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma-like cells) and intranodal DOX release was activated using near-infrared (NIR) laser irradiation...
April 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28415398/combinatorial-delivery-of-superparamagnetic-iron-oxide-nanoparticles-%C3%AE-fe2o3-and-doxorubicin-using-folate-conjugated-redox-sensitive-multiblock-polymeric-nanocarriers-for-enhancing-the-chemotherapeutic-efficacy-in-cancer-cells
#19
Chetan Nehate, M R Aji Alex, Arun Kumar, Veena Koul
Redox sensitive, folate conjugated multiblock polymeric system of (-PLGA-PEG-PLGA-urethane-ss-) demonstrated self-assembly into stable nanoplatforms. The polymeric nanocarriers were encapsulated with doxorubicin and highly crystalline γFe2O3 superparamagnetic iron oxide nanoparticles (SPIONs), for co-delivery of the same to cancer cells, with average particle size of ~170nm and zeta potential of ~-33mV. Furthermore, the designed formulation was evaluated for protein adsorption, hemo-cytocompatibility and stability...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413682/multi-focal-hifu-reduces-cavitation-in-mild-hyperthermia
#20
Vandiver Chaplin, Charles F Caskey
BACKGROUND: Mild-hyperthermia therapy (40-45 °C) with high-intensity focused ultrasound (HIFU) is a technique being considered in a number of different treatments such as thermally activated drug delivery, immune-stimulation, and as a chemotherapy adjuvant. Mechanical damage and loss of cell viability associated with HIFU-induced acoustic cavitation may pose a risk during these treatments or may hinder their success. Here we present a method that achieves mild heating and reduces cavitation by using a multi-focused HIFU beam...
2017: Journal of Therapeutic Ultrasound
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