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chemotherapy hyperthermia

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https://www.readbyqxmd.com/read/29141151/light-responsive-nanoparticles-for-highly-efficient-cytoplasmic-delivery-of-anticancer-agents
#1
Yangyun Wang, Yibin Deng, Huanhuan Luo, Aijun Zhu, Hengte Ke, Hong Yang, Huabing Chen
Stimuli-responsive nanostructures have shown great promise for intracellular delivery of anticancer compounds. A critical challenge remains in the exploration of stimuli-responsive nanoparticles for fast cytoplasmic delivery. Herein, near-infrared (NIR) light-responsive nanoparticles were rationally designed to generate highly efficient cytoplasmic delivery of anticancer agents for synergistic thermo-chemotherapy. The drug-loaded polymeric nanoparticles of selenium-inserted copolymer (I/D-Se-NPs) were rapidly dissociated in several minutes through reactive oxygen species (ROS)-mediated selenium oxidation upon NIR light exposure, and this irreversible dissociation of I/D-Se-NPs upon such a short irradiation promoted continuous drug release...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29135345/localized-drug-release-and-effective-chemotherapy-by-hyperthermia-governed-bubble-generating-hybrid-nanocapsule-system
#2
Ke Kang, Jin Ma, Qiangying Yi, Zhongwei Gu
AIM: To build up a remote triggering drug delivery system with hyperthermia-responsive ammonium bicarbonate salt and investigate its effects on tumor therapy. MATERIALS & METHODS: This hybrid nanocapsule system was prepared by a different strategy, doxorubicin (DOX) was encapsulated in the heparin shell first and then ammonium bicarbonate was diffused into the nanocapsules to generate DOX-bicarbonate salt, its characterizations and effects on tumor therapy were investigated...
November 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29134362/selecting-patients-for-hyperthermia-combined-with-preoperative-chemoradiotherapy-for-locally-advanced-rectal-cancer
#3
Sang-Won Kim, Ji Woon Yea, Jae Hwang Kim, Mi Jin Gu, Min Kyu Kang
BACKGROUND: This study investigated the role of hyperthermia combined with preoperative concurrent chemoradiotherapy (CCRT) for locally advanced rectal cancer (LARC) according to hypoxic marker expression. METHODS: One hundred and nine LARC patients with tissue blocks available for immunohistochemical assessment of carbonic anhydrase 9 (CA9) expression were reviewed. CA9 expression was considered positive when the staining percentage of tumor cells was >25% (n = 31)...
November 13, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29118984/clinical-trial-protocol-for-tardox-a-phase-i-study-to-investigate-the-feasibility-of-targeted-release-of-lyso-thermosensitive-liposomal-doxorubicin-thermodox%C3%A2-using-focused-ultrasound-in-patients-with-liver-tumours
#4
Paul C Lyon, Lucy F Griffiths, Jenni Lee, Daniel Chung, Robert Carlisle, Feng Wu, Mark R Middleton, Fergus V Gleeson, Constantin C Coussios
Background: TARDOX is a Phase I single center study of ultrasound triggered targeted drug delivery in adult oncology patients with incurable liver tumours. This proof of concept study is designed to demonstrate the safety and feasibility of targeted drug release and enhanced delivery of doxorubicin from thermally sensitive liposomes (ThermoDox®) triggered by mild hyperthermia induced by focused ultrasound in liver tumours. A key feature of the study is the direct quantification of the doxorubicin concentration before and after ultrasound exposure from tumour biopsies, using high performance liquid chromatography (HPLC)...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29071189/black-phosphorus-nanosheets-for-mild-hyperthermia-enhanced-chemotherapy-and-chemo-photothermal-combination-therapy
#5
Sheng Wang, Jian Weng, Xiao Fu, Jing Lin, Wenpei Fan, Nan Lu, JunLe Qu, Siping Chen, Tianfu Wang, Peng Huang
Near-infrared (NIR) light triggered photothermally enhanced cellular internalization strategy shows great potential to improve antitumor effect to fight against cancer. In this work, a black phosphorus (BP) nanosheet-based nanomedicine, which is composed of BP nanosheet, human serum albumin (HSA) and paclitaxel (PTX), was developed for mild hyperthermia-enhanced intracellular drug delivery and chemo-photothermal combination therapy. BP nanosheet was successfully synthesized by a one-pot biomimetic synthesis method using HSA as exfoliating agent and capping agent...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29057672/chemical-meningitis-related-to-intra-csf-liposomal-cytarabine
#6
B Durand, F Zairi, T Boulanger, J Bonneterre, L Mortier, Emilie Le Rhun
Therapeutic options of leptomeningeal metastases include intra-cerebrospinal fluid (CSF) chemotherapy. Among intra-CSF agents, liposomal cytarabine has advantages but can induce specific toxicities. A BRAF-V600E-mutated melanoma leptomeningeal metastases patient, treated by dabrafenib and liposomal cytarabine, presented after the first injection of liposomal cytarabine with hyperthermia and headaches. Despite sterile CSF/blood analyses, extended intravenous antibiotics were given and the second injection was delayed...
October 23, 2017: CNS Oncology
https://www.readbyqxmd.com/read/29030300/gold-nanocage-decorated-ph-sensitive-micelle-for-highly-effective-photothermo-chemotherapy-and-photoacoustic-imaging
#7
Guoyong Zhou, Hong Xiao, Xiaoxia Li, Yi Huang, Wei Song, Liang Song, Meiwan Chen, Du Cheng, Xintao Shuai
A pH-sensitive copolymer PAsp(DIP)-b-PAsp(MEA) (PDPM) was synthesized and self-assembled to micelle loading chemotherapeutic drug doxorubicin (DOX) and introducing a gold nanocage structure for photothermo-chemotherapy and photoacoustic imaging. After further surface modification with polyethylene glycol (PEG), the DOX-loaded pH-sensitive gold nanocage (D-PGNC) around 100 nm possessed a uniform spherical structure with a pH-sensitive core of PAsp(DIP) incorporating DOX, an interlayer crosslinked via disulfide bonds and decorated with discontinuous gold shell, and a PEG corona...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29024917/thermo-responsive-mesoporous-silica-lipid-bilayer-hybrid-nanoparticles-for-doxorubicin-on-demand-delivery-and-reduced-premature-release
#8
Qing Zhang, Xuanxuan Chen, Huihui Shi, Gaoqiu Dong, Meiling Zhou, Tianji Wang, Hongliang Xin
Hybrid nanocarriers based on mesoporous silica nanoparticles (MSNs) and supported lipid bilayer (SLB) have been studied as drug delivery system. It still remains challenges to develop these nanocarriers (SLB-MSNs) with on-demand drug release profile for chemotherapy. Here, we reported the biocompatible SLB-MSNs with high drug loading, which could release doxorubicin (DOX) in response to hyperthermia and reduce premature release. After synthesis of MSNs via a sol-gel procedure, the thermo-responsive SLB was deposited on the MSNs by sonication to completely seal the mesopores...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28971453/gold-rods-irradiated-with-ultrasound-for-combination-of-hyperthermia-and-cancer-chemotherapy
#9
Andre Barros, Carlos Austerlitz, Ioannis Gkigkitzis, Diana Campos, Jeyce Andrade, Christina Peixoto, Jaciana Aguiar, Silene Nascimento, Teresinha G Silva, Ioannis Haranas
PURPOSE: The aim of this study was to analyze feasibility (in vitro and in vivo) the use of hyperthermia produced by gold rods irradiated with ultrasound and their combination with chemotherapy with doxorubicin. MATERIALS AND METHODS: initially was determined the cell viability and Hsp70 levels after treatment by gold rods irradiated with ultrasound (GR+U) in cell culture. The pretreatment with GR+U combined with doxorubicin (DOX) was evaluated from IC50, caspase-3 expression and mechanisms of cell death by electron microscopy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28971442/preclinical-validation-of-the-located-hyperthermia-using-gold-macro-rods-and-ultrasound-as-an-effective-treatment-for-solid-tumors
#10
Andre L S Barros, Carlos Austerlitz, Ioannis Gkigkitzis, Diana Campos, Jeyce K F de Andrade, Teresinha G Silva, Silene C Nascimento, Ioannis Haranas
Hyperthermia, the procedure of raising the temperature of a part of or the whole body above normal for a defined period of time, is applied alone or as an adjunctive with various established cancer treatment modalities such as radiotherapy and chemotherapy. In this study used a method for inducing hyperthermia in solid tumors with a combination of gold macro rod (GR) and ultrasound, the feasibility of this technique was described only with computational models and in vitro. The Ehrlich tumor, derived from a mouse adenocarcinoma, has been used to investigate the bio-heat transfer and the effect of gold rods irradiated with ultrasound...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28944118/dramatic-response-of-an-aggressive-chest-wall-recurrence-to-hyperthermia-radiation-and-chemotherapy
#11
Justin Cohen, Stephanie Rice, Tejan Diwanji, Steven J Feigenberg, Zeljko Vujaskovic
Hyperthermia has been demonstrated to be an effective adjuvant oncological treatment modality in combination with chemotherapy and/or radiation. Published data have demonstrated that the addition of hyperthermia can improve local control for breast cancer chest wall recurrences. We present a patient with a very aggressive estrogen receptor-negative, progesterone receptor-negative, HER2/neu receptor-negative chest wall recurrence status-post a right modified radical mastectomy. Despite having metastatic disease, in an attempt to achieve local control and provide palliation, she was treated with hyperthermia, radiation, and chemotherapy...
July 16, 2017: Curēus
https://www.readbyqxmd.com/read/28926732/multifunctional-mesoporous-zro2-encapsulated-upconversion-nanoparticles-for-mild-nir-light-activated-synergistic-cancer-therapy
#12
Lili Feng, Shili Gai, Fei He, Yunlu Dai, Chongna Zhong, Piaoping Yang, Jun Lin
Desirable nanosystem that could not only deliver drugs safely and effectively into tumor sites, but also be expected to serve as photosensitizer to realize the photodynamic therapeutic function, would be of great significance in the synergistic cancer therapy. To perform this task, a multifunctional nanosystem has been developed for markedly enhanced cancer therapeutic efficacy by loading chemotherapy agent (doxorubicin hydrochloride, DOX) and photosensitive drug chlorin e6 (Ce6) into the channels of mesoporous zirconium dioxide (ZrO2) layer which coats on Nd(3+)-doped upconversion nanoparticles (UCNPs)...
December 2017: Biomaterials
https://www.readbyqxmd.com/read/28924531/efficacy-of-metabolically-supported-chemotherapy-combined-with-ketogenic-diet-hyperthermia-and-hyperbaric-oxygen-therapy-for-stage-iv-triple-negative-breast-cancer
#13
Mehmet Salih İyikesici, Abdul Kadir Slocum, Ayshe Slocum, Ferhan Bulent Berkarda, Miriam Kalamian, Thomas N Seyfried
Triple-negative breast cancer (TNBC) is more aggressive and metastatic than other breast cancer types. Cytotoxic chemotherapy is presently the predominant systemic therapy for TNBC patients. This case report highlights the influence of metabolically supported chemotherapy (MSCT), ketogenic diet (KD), hyperthermia (HT), and hyperbaric oxygen therapy (HBOT) in an overweight 29-year-old woman with stage IV (T4N3M1) triple-negative invasive ductal carcinoma of the breast. The patient presented with an observable mass in her left breast detected during a physical examination in December 2015...
July 7, 2017: Curēus
https://www.readbyqxmd.com/read/28901139/injectable-and-self-healing-thermosensitive-magnetic-hydrogel-for-asynchronous-control-release-of-doxorubicin-and-docetaxel-to-treat-triple-negative-breast-cancer
#14
Wensheng Xie, Qin Gao, Zhenhu Guo, Dan Wang, Fei Gao, Xiumei Wang, Yen Wei, Lingyun Zhao
Integration of two or more drugs into a multiagent delivery system has been considered to have profound impact on both in vitro and in vivo cancer treatment due to their efficient synergistic effect. This study presents a cheap and simple chitosan hydrogel cross-linked with telechelic difunctional poly(ethylene glycol) (DF-PEG-DF) for synthesis of an injectable and self-healing thermosensitive dual-drug-loaded magnetic hydrogel (DDMH), which contains both doxorubicin (DOX) and docetaxel (DTX) for chemotherapy and iron oxide for magnetic hyperthermia induced stimuli responsive drug release...
October 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28870927/response-of-ovcar-3-cells-to-cisplatin-and-hyperthermia-does-hyperthermia-really-matter
#15
Arturas Sukovas, Vaidotas Cesna, Aldona Jasukaitiene, Giedrius Barauskas, Ruta Jolanta Nadisauskiene, Zilvinas Dambrauskas, Saulius Paskauskas, Antanas Gulbinas
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) is proposed as a promising treatment method, but fundamental information about the contribution of hyperthermia to intraperitoneal chemotherapy is lacking. The purpose of this study was to investigate the cytotoxic effect of hyperthermia and cisplatin on OVCAR-3 cells in vitro. MATERIALS AND METHODS: Imitating the typical clinical conditions of HIPEC, OVCAR-3 cells were exposed to hyperthermia and cisplatin for 1 h...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28843746/cytological-and-histological-changes-in-the-urothelium-produced-by-electromotive-drug-administration-emda-and-by-the-combination-of-intravescical-hyperthermia-and-chemotherapy-thermochemotherapy
#16
Francesco Pierconti, Patrizia Straccia, Sacco Emilio, Pier Francesco Bassi, Ivana De Pascalis, Rita C Marques, Metka Volavsek, Luigi M Larocca, Antonio Lopez-Beltran
The treatment of non muscle-invasive bladder cancer (NMIBC) encompasses a range of different procedures. Electromotive drug administration (EMDA) and chemo-hyperthermia (C-HT; Synergo) represent a minimally-invasive methods of intravesical instillation of therapeutic agents as mitomycin C (MMC). We selected patients with high grade NMIBC, BCG non responder, treated with EMDA/MMC and C-HT/MMC and we also examined the morphological changes in urine cytology samples. During the period from 2012 to 2014, 110 patients with high grade NMIBC, BCG refractory were selected...
August 1, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28842557/functionalized-non-vascular-nitinol-stent-via-electropolymerized-polydopamine-thin-film-coating-loaded-with-bortezomib-adjunct-to-hyperthermia-therapy
#17
Ludwig Erik Aguilar, Batgerel Tumurbaatar, Amin Ghavaminejad, Chan Hee Park, Cheol Sang Kim
Gastrointestinal malignancies have been a tremendous problem in the medical field and cover a wide variety of parts of the system, (i.e. esophagus, duodenum, intestines, and rectum). Usually, these malignancies are treated with palliation with the use of non-vascular nitinol stents. However, stenting is not a perfect solution for these problems. While it can enhance the quality of life of the patient, in time the device will encounter problems such as re-occlusion due to the rapid growth of the tumor. In this study, we propose a functionalization technique using electropolymerization of polydopamine directly onto the nitinol stent struts for the combined application of hyperthermia and chemotherapy...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837053/a-multi-controlled-drug-delivery-system-based-on-magnetic-mesoporous-fe3o4-nanopaticles-and-a-phase-change-material-for-cancer-thermo-chemotherapy
#18
Qi Zhang, Jian Liu, Kunjie Yuan, Zhengguo Zhang, Xiaowen Zhang, Xiaoming Fang
Herein a novel multi-controlled drug release system for doxorubicin (DOX) was developed, in which monodisperse mesoporous Fe3O4 nanoparticles were combined with a phase change material (PCM) and polyethylene glycol 2000 (PEG2000). It is found that the PCM/PEG/DOX mixture containing 20% PEG could be dissolved into water at 42 °C. The mesoporous Fe3O4 nanoparticles prepared by the solvothermal method had sizes of around 25 nm and exhibited a mesoporous microstructure. A simple solvent evaporation process was employed to load the PCM/PEG/DOX mixture on the mesoporous Fe3O4 nanoparticles completely...
August 24, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28830646/dynamics-of-patient-reported-quality-of-life-and-symptoms-in-the-acute-phase-of-online-adaptive-external-beam-radiation-therapy-for-locally-advanced-cervical-cancer
#19
S T Heijkoop, R A Nout, S Quint, J W M Mens, B J M Heijmen, M S Hoogeman
OBJECTIVE: For locally advanced cervical cancer patients, treated with External Beam Radiotherapy (EBRT), Quality of Life (QoL) questionnaires arefrequently used to evaluate treatment-related symptoms and functioning scales. Currently, it is unknown how those evolve during the radiation treatment course. In this prospective study we report on weekly-captured patient-reported QoL and symptoms during image-guided adaptive radiotherapy (IGART) of cervical cancer patients. MATERIAL AND METHODS: Between January 2012 and September 2016, all locally advanced cervical cancer patients treated with IGART and brachytherapy with or without chemotherapy or hyperthermia, were eligible...
November 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28826283/radiotherapy-and-hyperthermia-with-curative-intent-in-recurrent-high-risk-soft-tissue-sarcomas
#20
Franziska Eckert, Lore Helene Braun, Frank Traub, Hans-Georg Kopp, Bence Sipos, Ulf Lamprecht, Arndt-Christian Müller, Frank Paulsen, Daniel Zips
PURPOSE: Radiotherapy before or after resection is one of the pillars of treatment for localised high risk soft tissue sarcomas. Treatment intensification has been described with concurrent chemotherapy and hyperthermia. The aim of this study is to assess local control after multimodal treatment, focussing on the treatment of local recurrences after surgery only. PATIENTS AND METHODS: Of 42 patients treated in a prospective protocol with radiotherapy and hyperthermia, nine were treated for isolated local recurrences without metastatic spread...
August 21, 2017: International Journal of Hyperthermia
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