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Johannes Budjan, Elke A Sauter, John N Morelli, Marco Nolden, Andreas Fetzer, Lothar Pilz, Miriam Reichert, Theresa Brandt, Jan Hansmann, Stefan Haneder, Nils Rathmann, Steffen J Diehl, Hans-Peter Meinzer, Stefan O Schoenberg, Ulrike I Attenberger
AIM: To perform a quantitative, volumetric analysis of therapeutic effects of trans-arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. PATIENTS AND METHODS: Entire tumor volume and a subset of hypervascular tumor portions were analyzed pre- and post-TACE in magnetic resonance imaging datasets of 22 HCC patients using a semi-automated segmentation and evaluation tool from the Medical Imaging Interaction Toolkit. Results were compared to mRECIST measurements and inter-reader variability was assessed...
August 2016: Anticancer Research
Anika Jonitz-Heincke, Katrin Lochner, Christoph Schulze, Diana Pohle, Wera Pustlauk, Doris Hansmann, Rainer Bader
One of the major reasons for failure after total joint arthroplasty is aseptic loosening of the implant. At articulating surfaces, defined as the interface between implant and surrounding bone cement, wear particles can be generated and released into the periprosthetic tissue, resulting in inflammation and osteolysis. The aim of the present study was to evaluate the extent to which osteoblasts and macrophages are responsible for the osteolytic and inflammatory reactions following contact with generated wear particles from Ti‑6Al‑7Nb and Co‑28Cr‑6Mo hip stems...
August 2016: Molecular Medicine Reports
Laurent Calvier, Ekaterina Legchenko, Lena Grimm, Hannes Sallmon, Adam Hatch, Brian D Plouffe, Christoph Schroeder, Johann Bauersachs, Shashi K Murthy, Georg Hansmann
BACKGROUND: Several studies have identified circulating biomarkers to be associated with the presence and severity of pulmonary arterial hypertension (PAH). Recent evidence supports a role for galectin-3 (Gal-3) and the mineralcorticoid aldosterone in left ventricular failure. However, studies on aldosterone together with Gal-3 in PAH are lacking. OBJECTIVE: We investigated a novel Aldosterone-galectin-3 (Gal-3) tandem and several other potential PAH biomarkers and their association with the disease severity...
March 2016: Heart: Official Journal of the British Cardiac Society
Jan Hansmann, Paul Apfaltrer, Frank G Zoellner, Thomas Henzler, Mathias Meyer, Gerald Weisser, Stefan O Schoenberg, Ulrike I Attenberger
AIM: To correlate dual-energy computed tomography (DECT) pulmonary angiography derived iodine maps with parameter maps of quantitative pulmonary perfusion magnetic resonance imaging (MRI). METHODS: Eighteen patients with pulmonary perfusion defects detected on DECT derived iodine maps were included in this prospective study and additionally underwent time-resolved contrast-enhanced pulmonary MRI [dynamic contrast enhanced (DCE)-MRI]. DCE-MRI data were quantitatively analyzed using a pixel-by-pixel deconvolution analysis calculating regional pulmonary blood flow (PBF), pulmonary blood volume (PBV) and mean transit time (MTT) in visually normal lung parenchyma and perfusion defects...
May 28, 2013: World Journal of Radiology
Jan Hansmann, Christian Fink, Gregor Jost, Hubertus Pietsch, Mathias Meyer, John W Nance, Uwe J Schoepf, Ulrike I Attenberger, Stefan O Schoenberg, Thomas Henzler
RATIONALE AND OBJECTIVES: To prospectively compare four contrast material injection protocols for dual-energy computed tomography (CT) pulmonary angiography (DE-CTPA) in patients with suspected pulmonary embolism (PE). MATERIALS AND METHODS: One hundred twenty consecutive patients were randomized to contrast material injection protocols defined by different iodine concentrations and iodine delivery rates (IDRs): (A) 80 mL iopromide 370/4 mL/sec = IDR 1.4 gI/sec; (B) 80 mL iopromide 370 at 3 mL/sec = IDR 1...
August 2013: Academic Radiology
Xavier Argemi, Yves Hansmann, Daniel Christmann, Sophie Lefebvre, Benoit Jaulhac, François Jehl
Enterococcus faecalis (E. faecalis) has become a major leading cause of nosocomial endocarditis. Treatment of such infections remains problematic and new therapeutic options are needed. Nine E. faecalis strains were tested: six obtained from patients presenting endocarditis, one with isolated bacteremia, and two reference strains. Antibiotics included daptomycin, alone or in combination, linezolid, tigecycline, rifampicin, gentamicin, teicoplanin, ceftriaxone and amoxicillin. Time-kill studies included colony counts at 1, 4 and 24 h of incubation...
2013: PloS One
Dirk Holzinger, Michael Frosch, Astrid Kastrup, Femke H M Prince, Marieke H Otten, Lisette W A Van Suijlekom-Smit, Rebecca ten Cate, Esther P A H Hoppenreijs, Sandra Hansmann, Halima Moncrieffe, Simona Ursu, Lucy R Wedderburn, Johannes Roth, Dirk Foell, Helmut Wittkowski
BACKGROUND: Analysis of myeloid-related protein 8 and 14 complex (MRP8/14) serum concentrations is a potential new tool to support the diagnosis of systemic-onset juvenile idiopathic arthritis (SJIA) in the presence of fever of unknown origin. OBJECTIVE: To test the ability of MRP8/14 serum concentrations to monitor disease activity in patients with SJIA and stratify patients at risk of relapse. METHODS: Serum concentrations of MRP8/14 in 52 patients with SJIA were determined by a sandwich ELISA...
June 2012: Annals of the Rheumatic Diseases
David W Newell, M Mohsin Shah, Robert Wilcox, Douglas R Hansmann, Erik Melnychuk, John Muschelli, Daniel F Hanley
OBJECT: Catheter-based evacuation is a novel surgical approach for the treatment of brain hemorrhage. The object of this study was to evaluate the safety and efficacy of ultrasound in combination with recombinant tissue plasminogen activator (rt-PA) delivered through a microcatheter directly into spontaneous intraventricular (IVH) or intracerebral (ICH) hemorrhage in humans. METHODS: Thirty-three patients presenting to the Swedish Medical Center in Seattle, Washington, with ICH and IVH were screened between November 21, 2008, and July 13, 2009, for entry into this study...
September 2011: Journal of Neurosurgery
Azita Soltani, Ruchi Singhal, Melissa Obtera, Ronald A Roy, Wayne M Clark, Douglas R Hansmann
Transcranial ultrasound in combination with intravenously administered ultrasound contrast agents (UCA) in the presence or absence of recombinant tissue plasminogen activator (rt-PA) has been widely evaluated as a new modality for treatment of ischemic stroke. Despite the successful demonstration of accelerated clot lysis there are inherent limitations associated with this modality such as inconsistency in temporal window thickness and/or potential serious cardiopulmonary reactions to intravenous administration of UCA that prevent broad application to ischemic stroke populations...
January 2011: Journal of Thrombosis and Thrombolysis
Andreas Conrad, Cathrin Hansmann, Inge Engels, Franz D Daschner, Uwe Frank
Clinical data show that EPs 7630, an aqueous ethanolic extract from the roots of Pelargonium sidoides, can be used for the treatment of upper respiratory tract infections (URTI). The biological effects of the preparation have not been fully investigated. The objective of this study was to examine the impact of EPs 7630 on the activity of human peripheral blood phagocytes (PBP). A whole blood-based, flow cytometric assay was used to simultaneously assess phagocytosis and oxidative burst. Calcein-AM stained Candida albicans (DSM 1386) were used as target organisms...
2007: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Robert Arnulf Wahl, Christian Vorländer, Susanne Kriener, Johanna Pedall, Martin Spitza, Martin-Leo Hansmann
BACKGROUND: Autopsy studies show that C cells deriving from the ultimobranchial body and migrating into the thyroid do not reach the isthmus region and are distributed along the vertical axes of thyroid lobes. This was confirmed in a surgical series of 58 patients (34 with preoperatively normal and 24 with elevated serum calcitonin) where no calcitonin-positive cells were demonstrable immunohistochemically within separately investigated isthmi. Consequently, isthmus-preserving total bilateral lobectomy (IPTB) may be regarded as an adequate surgical procedure for C-cell hyperplasia (CCH)...
May 2006: World Journal of Surgery
Thomas Diebold, Tanja Hahn, Christine Solbach, Achim Rody, Joern O Balzer, Martin L Hansmann, Andreas Marx, Fernando Viana, Jutta Peters, Volkmar Jacobi, Manfred Kaufmann, Thomas J Vogl
PURPOSE: The purpose of this study was to evaluate the potential of the new 8G stereotactic vacuum-assisted breast biopsy (ST-driver, Mammotome; Ethicon Endosurgery) in the histologic evaluation of BI-RADS IV microcalcifications. MATERIALS AND METHODS: Fifty-eight patients with 61 mammographic BI-RADS IV microcalcifications underwent stereotactic vacuum-assisted breast biopsy (SVAB). The new 8G system was mounted on the ST driver, which was formerly used only with the hand-held version under sonographic guidance...
July 2005: Investigative Radiology
Andreas Hansmann, Maarten F Schim van der Loeff, Steve Kaye, Akum Aveika Awasana, Ramu Sarge-Njie, Diarmuid O'Donovan, Koya Ariyoshi, Abraham Alabi, Paul Milligan, Hilton C Whittle
OBJECTIVES: To estimate and compare the all-cause mortality rates among HIV-1-infected, HIV-2-infected, and uninfected women and to assess the predictive value of baseline plasma viral load (PVL) and CD4 cell percentage (CD4%) for mortality. DESIGN: Cohort study. METHODS: At presentation to antenatal clinics in The Gambia in 1993-1995, pregnant women were screened for antibodies to HIV-1 and HIV-2. Seropositive subjects and a similar number of seronegative controls were enrolled, and baseline PVL and CD4% were measured...
March 1, 2005: Journal of Acquired Immune Deficiency Syndromes: JAIDS
C Fink, L Grenacher, H J Hansmann, M Düx, R Leipold, E Spielhaupter, G W Kauffmann, G M Richter
PURPOSE: To compare thin-section hydro-CT and MRI in the detection of pancreatic neoplasms. Evaluation of an oral, superparamagnetic contrast agent (OMP) for pancreatic MRI. MATERIAL AND METHODS: 45 patients with suspected pancreatic neoplasms were examined with consecutive thin-section helical CT (Hydro-CT, 3/6/3, 130 ml Ultravist, Schering) and MRI (1.0 T, breath-holding, T1w-GRE, T1w-GRE fat-sat, T2w-TSE). The MRI protocol included precontrast studies, studies after oral administration of OMP (Abdoscan, Nycomed Amersham) and studies after administration of OMP and Gadodiamide i...
August 2001: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
M Martinot, Y Hansmann, S De Martino, O Lesens, G Coumaros, E Pencreach, M Bertrand, D Christmann
OBJECTIVES: Procalcitonin (PCT) is an acute-phase protein involved in the specific inflammatory reaction to severe bacterial or fungal infections. This protein does however lack sensitivity in focal infections. PATIENTS AND METHODS: In this study, we investigated PCT, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), leukocytosis, and fibrinogen levels at admission among adult patients hospitalized for community-acquired pneumonia (n = 33) or pyelonephritis (n = 30) and in a control population (n = 27) of patients with viral infections and non-infectious inflammatory diseases...
June 30, 2001: La Presse Médicale
R L Schild, C Knobloch, C Dorn, R Fimmers, H van der Ven, M Hansmann
The study was designed to investigate the role of ovarian volume, as assessed by three-dimensional (3D) sonography, in predicting conception in an in-vitro fertilization-embryo transfer (IVF-ET) programme. Transvaginal 3D sonography was performed in 152 cycles before initiation of ovarian stimulation (day 1) and on the day of oocyte retrieval. Ovarian volume showed no significant correlation with IVF outcome. On the contrary, all ovarian measurements were lower, albeit nonsignificantly, in the conception group...
May 2001: Archives of Gynecology and Obstetrics
R L Schild, C Knobloch, C Dorn, R Fimmers, H van der Ven, M Hansmann
OBJECTIVE: To investigate the role of sonographic parameters in assessing endometrial receptivity in an in vitro fertilization (IVF) program. DESIGN: Prospective clinical study. SETTING: University setting. PATIENT(S): One hundred thirty-five patients in our IVF program, selected prospectively on the day of oocyte retrieval. INTERVENTION(S): Transvaginal ultrasound examination was performed before oocyte collection...
February 2001: Fertility and Sterility
H J Hansmann, N Döbert, H Kücherer, G M Richter
PURPOSE: Development of an optimized Spiral CT protocol type for the diagnosis of aortic dissections. MATERIAL AND METHODS: 121 consecutive CT examinations applying 5 different protocol types were blindly read by two experienced radiologists and then compared with: (a) 45 biplane transesophageal echocardiographies (TEE), (b) 52 transthoracic echocardiographies (TTE), (c) 52 operative findings and, furthermore, related to the clinical course over at least six months in 79 patients...
November 2000: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
M Düx, G M Richter, J Hansmann, C Kuntz, G W Kauffmann
PURPOSE: The purpose of this work was to define the accuracy of helical hydro-CT (HHCT) in the diagnosis and staging of gastric carcinoma. METHOD: One hundred twelve patients with gastric carcinoma were preoperatively imaged by HHCT. Gastric distension was achieved by ingestion of up to 1,500 ml of water. Bolus tracking was performed, and peristalsis was minimized by intravenously administered spasmolytics. Contrast material was then injected, and helical scanning was performed at the time of peak enhancement of the liver...
November 1999: Journal of Computer Assisted Tomography
A Cecille, H Schuster, Y Hansmann, M J Wendling, D Christmann, J P Gut
Neurological complications following rubella are only rarely encountered. We report a case of isolated myelitis. A 44-year-old healthy female suffered from an erythematous macular rash which rapidly cleared. However, the following days, dysuria initiated hospitalization. On admission, she was febrile but alert and in normal mental status. General physical examination was quite unremarkable. Four days later, she suffered from acute urinary retention, fecal retention and vaginal hypoesthesia. Routine laboratory data, chest skull and spinal column X-rays were unremarkable...
May 1999: Pathologie-biologie
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