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Jeanette K Doorduijn, Gustaaf W van Imhoff, Bronno van der Holt, Harry C Schouten, Martijn R Schaafsma, Marius A MacKenzie, Joke W Baars, Marie José Kersten, Pieternella J Lugtenburg, Martin J van den Bent, Roelien H Enting, Fokje M Spoelstra, Philip Poortmans, Jacoline E C Bromberg
The prognosis of central nervous system (CNS) relapse of systemic non-Hodgkin lymphoma is poor with 1-year survival historically at 0% to 20%. Aiming to improve these results, we performed a multicenter phase 2 study in patients with a CNS relapse, with or without concurrent systemic relapse. Treatment consisted of 2 cycles of R-DHAP alternating with high-dose methotrexate (MTX) and was combined with intrathecal rituximab. Responding patients received a third R-DHAP-MTX cycle followed by busulfan and cyclophosphamide myeloablative therapy and autologous stem cell transplantation...
August 17, 2016: Hematological Oncology
Joan E Walter, Marjolein A Heuvelmans, Pim A de Jong, Rozemarijn Vliegenthart, Peter M A van Ooijen, Robin B Peters, Kevin Ten Haaf, Uraujh Yousaf-Khan, Carlijn M van der Aalst, Geertruida H de Bock, Willem Mali, Harry J M Groen, Harry J de Koning, Matthijs Oudkerk
BACKGROUND: US guidelines now recommend lung cancer screening with low-dose CT for high-risk individuals. Reports of new nodules after baseline screening have been scarce and are inconsistent because of differences in definitions used. We aimed to identify the occurrence of new solid nodules and their probability of being lung cancer at incidence screening rounds in the Dutch-Belgian Randomized Lung Cancer Screening Trial (NELSON). METHODS: In the ongoing, multicentre, randomised controlled NELSON trial, between Dec 23, 2003, and July 6, 2006, 15 822 participants who had smoked at least 15 cigarettes a day for more than 25 years or ten cigarettes a day for more than 30 years and were current smokers, or had quit smoking less than 10 years ago, were enrolled and randomly assigned to receive either screening with low-dose CT (n=7915) or no screening (n=7907)...
July 2016: Lancet Oncology
Mehmet Faruk Çatma, Serhan Ünlü, Alper Öztürk, Atıf M Aksekili, Önder Ersan, Yalım Ateş
PURPOSE: The purpose of this study was to compare two distinct fixation methods for a total hip replacement performed via transverse femoral shortening osteotomy for patients with severe hip dysplasia. METHODS: In this retrospective study we compared two fixation methods for total hip replacement of 78 hips in 76 patients exhibiting Crowe type IV developmental hip dysplasia (DDH). The hip replacements were performed via a transverse femoral shortening osteotomy and carried out between September 2009 and December 2013...
March 3, 2016: International Orthopaedics
Kellie A Charles, Benjamin D W Harris, Carol R Haddad, Stephen J Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J Gill, Michael Back, David Veivers, Thomas Eade
BACKGROUND: Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clinical outcomes in a heterogeneous cohort of HNSCC cancer patients. METHODS: We performed a retrospective analysis to identify associations between NLR and clinicopathological features to recurrence free survival (RFS) and overall survival (OS)...
2016: BMC Cancer
Claire L Jackson, Laura Behan, Samuel A Collins, Patricia M Goggin, Elizabeth C Adam, Janice L Coles, Hazel J Evans, Amanda Harris, Peter Lackie, Samantha Packham, Anton Page, James Thompson, Woolf T Walker, Claudia Kuehni, Jane S Lucas
Diagnosis of primary ciliary dyskinesia (PCD) lacks a "gold standard" test and is therefore based on combinations of tests including nasal nitric oxide (nNO), high-speed video microscopy analysis (HSVMA), genotyping and transmission electron microscopy (TEM). There are few published data on the accuracy of this approach.Using prospectively collected data from 654 consecutive patients referred for PCD diagnostics we calculated sensitivity and specificity for individual and combination testing strategies. Not all patients underwent all tests...
March 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Soroush Ardekani, Harry A Scott, Sharad Gupta, Shane Eum, Xiao Yang, Alexander R Brunelle, Sean M Wilson, Umar Mohideen, Kaustabh Ghosh
Nitroglycerin (NTG) markedly enhances nitric oxide (NO) bioavailability. However, its ability to mimic the anti-inflammatory properties of NO remains unknown. Here, we examined whether NTG can suppress endothelial cell (EC) activation during inflammation and developed NTG nanoformulation to simultaneously amplify its anti-inflammatory effects and ameliorate adverse effects associated with high-dose NTG administration. Our findings reveal that NTG significantly inhibits human U937 cell adhesion to NO-deficient human microvascular ECs in vitro through an increase in endothelial NO and decrease in endothelial ICAM-1 clustering, as determined by NO analyzer, microfluorimetry, and immunofluorescence staining...
November 20, 2015: Scientific Reports
Cornelis Verhoef, Neil Singla, Greg Moneta, William Muir, Arjen Rijken, Harry Lockstadt, Johannes H W de Wilt, Albert O-Yurvati, Linda A Zuckerman, Paul Frohna, Robert J Porte
BACKGROUND: Fibrocaps, a ready-to-use, dry-powder fibrin sealant containing human plasma-derived thrombin and fibrinogen, is being developed as an adjunct for surgical hemostasis. MATERIALS AND METHODS: Safety and efficacy of Fibrocaps applied directly or by spray device, in combination with gelatin sponge, was compared with that of gelatin sponge-alone in two randomized, single-blind controlled trials: FC-002 US (United States) and FC-002 NL (the Netherlands). A total of 126 adult patients were randomized (Fibrocaps: n = 47 [FC-002 US], n = 39 [FC-002 NL]; gelatin sponge alone: n = 23 [FC-002 US], n = 17 [FC-002 NL)...
April 2015: Journal of Surgical Research
Nanda Horeweg, Joost van Rosmalen, Marjolein A Heuvelmans, Carlijn M van der Aalst, Rozemarijn Vliegenthart, Ernst Th Scholten, Kevin ten Haaf, Kristiaan Nackaerts, Jan-Willem J Lammers, Carla Weenink, Harry J Groen, Peter van Ooijen, Pim A de Jong, Geertruida H de Bock, Willem Mali, Harry J de Koning, Matthijs Oudkerk
BACKGROUND: The main challenge in CT screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer. Management protocols use thresholds for nodule size and growth rate to determine which nodules require additional diagnostic procedures, but these should be based on individuals' probabilities of developing lung cancer. In this prespecified analysis, using data from the NELSON CT screening trial, we aimed to quantify how nodule diameter, volume, and volume doubling time affect the probability of developing lung cancer within 2 years of a CT scan, and to propose and evaluate thresholds for management protocols...
November 2014: Lancet Oncology
Nanda Horeweg, Ernst Th Scholten, Pim A de Jong, Carlijn M van der Aalst, Carla Weenink, Jan-Willem J Lammers, Kristiaan Nackaerts, Rozemarijn Vliegenthart, Kevin ten Haaf, Uraujh A Yousaf-Khan, Marjolein A Heuvelmans, Erik Thunnissen, Matthijs Oudkerk, Willem Mali, Harry J de Koning
BACKGROUND: Low-dose CT screening is recommended for individuals at high risk of developing lung cancer. However, CT screening does not detect all lung cancers: some might be missed at screening, and others can develop in the interval between screens. The NELSON trial is a randomised trial to assess the effect of screening with increasing screening intervals on lung cancer mortality. In this prespecified analysis, we aimed to assess screening test performance, and the epidemiological, radiological, and clinical characteristics of interval cancers in NELSON trial participants assigned to the screening group...
November 2014: Lancet Oncology
Amanda Harris, Esther Bhullar, Kerry Gove, Rhiannon Joslin, Jennifer Pelling, Hazel J Evans, Woolf T Walker, Jane S Lucas
BACKGROUND: Nasal nitric oxide (nNO) levels are very low in primary ciliary dyskinesia (PCD) and it is used as a screening test. METHODS: We assessed the reliability and usability of a hand-held analyser in comparison to a stationary nitric oxide (NO) analyser in 50 participants (15 healthy, 13 PCD, 22 other respiratory diseases; age 6-79 years). Nasal NO was measured using a stationary NO analyser during a breath-holding maneuver, and using a hand-held analyser during tidal breathing, sampling at 2 ml/sec or 5 ml/sec...
2014: BMC Pulmonary Medicine
Muriel Thomas, Lydie Lemonnier, Vincent Gulmans, Lutz Naehrlich, François Vermeulen, Harry Cuppens, Carlo Castellani, Aleksandra Norek, Kris De Boeck
BACKGROUND: Cystic fibrosis (CF) spans a wide spectrum. Therefore, benchmarking between registries implies comparing similar cohorts. OBJECTIVE AND METHODS: Explore patient characteristics in Belgian (B), French (F), German (G) and Dutch (NL) registries (total N=13,122) and determine whether they fulfill predefined diagnostic criteria. RESULTS: Using as case definition sweat chloride >60mmol/L or 2 CFTR mutations identified, CF diagnosis was not documented in 2...
May 2014: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Firdaus A A Mohamed Hoesein, Michael Schmidt, Onno M Mets, Hester A Gietema, Jan-Willem J Lammers, Pieter Zanen, Harry J de Koning, Carlijn van der Aalst, Matthijs Oudkerk, Rozemarijn Vliegenthart, Ivana Isgum, Mathias Prokop, Bram van Ginneken, Eva M van Rikxoort, Pim A de Jong
BACKGROUND: Finding phenotypes within COPD patients may prove imperative for optimizing treatment and prognosis. We hypothesized that it would be possible to discriminate emphysematous, large airway wall thickening and small airways disease dominant phenotypes. METHODS: Inspiratory and expiratory CTs were performed in 1140 male smokers without or with mild COPD to quantify emphysema, airway wall thickness and air trapping. Spirometry, residual volume to total lung capacity (RV/TLC) and diffusion capacity (Kco) were measured...
January 2014: Respiratory Medicine
N J Menzies-Gow, H Wray, S R Bailey, P A Harris, J Elliott
REASONS FOR PERFORMING STUDY: The mechanisms underlying predisposition to pasture-associated laminitis remain unclear; chronic inflammation is implicated, and this may be exacerbated by physical inactivity. OBJECTIVES: To determine whether exercise affects the inflammatory profile of normal and previously laminitic ponies. STUDY DESIGN: Prospective case-control study. METHODS: The short (1 day) and longer term (14 days) effects of low intensity (10 min walking and 5 min trotting) exercise on plasma inflammatory marker concentrations in normal (NL) and previously laminitic (PL) nonobese ponies (n = 6/group) was determined...
May 2014: Equine Veterinary Journal
Catherine Carr, Sahil Shah, Go Ashida, Thomas McColgan, Hermann Wagner, Paula T Kuokkanen, Richard Kempter, Christine Köppl
Axons from the nucleus magnocellularis (NM) and their targets in nucleus laminaris (NL) form the circuit responsible for encoding interaural time differences (ITDs). In barn owls, NL receives bilateral inputs from NM such that axons from the ipsilateral NM enter NL dorsally, while contralateral axons enter from the ventral side. These afferents and their synapses on NL neurons generate a tone-induced local field potential, or neurophonic, that varies systematically with position in NL. From dorsal to ventral within the nucleus, the best interaural time difference (ITD) of the neurophonic shifts from contralateral space to best ITDs around 0 µs...
2013: Advances in Experimental Medicine and Biology
Firdaus A A Mohamed Hoesein, Pieter Zanen, Pim A de Jong, Bram van Ginneken, H Marike Boezen, Harry J M Groen, Mathijs Oudkerk, Harry J de Koning, Dirkje S Postma, Jan-Willem J Lammers
BACKGROUND: Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers. METHODS: 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up...
2013: Respiratory Research
H Wray, J Elliott, S R Bailey, P A Harris, N J Menzies-Gow
REASONS FOR PERFORMING STUDY: The mechanisms underlying individual animal predisposition to pasture-associated laminitis remain unclear; however, chronic inflammation is implicated. OBJECTIVES: To identify differences in the inflammatory profile of a group of previously laminitic ponies compared with control animals at pasture in late spring and winter. METHODS: Previously laminitic (PL; n = 38 and 42) and nonlaminitic control ponies (NL; n = 41 and 39) were sampled in late spring and winter...
September 2013: Equine Veterinary Journal
Nanda Horeweg, Carlijn M van der Aalst, Erik Thunnissen, Kristiaan Nackaerts, Carla Weenink, Harry J M Groen, Jan-Willem J Lammers, Joachim G Aerts, Ernst T Scholten, Joost van Rosmalen, Willem Mali, Matthijs Oudkerk, Harry J de Koning
RATIONALE: The NELSON (Nederlands Leuvens Longkanker Screenings Onderzoek) trial is, with 15,822 participants, the largest European lung cancer computer tomography screening trial. A volumetry-based screening strategy, stringent criteria for a positive screening, and an increasing length of screening interval are particular features of the NELSON trial. OBJECTIVES: To determine the effect of stringent referral criteria and increasing screening interval on the characteristics of screen-detected lung cancers, and to compare this across screening rounds, between sexes, and with other screening trials...
April 15, 2013: American Journal of Respiratory and Critical Care Medicine
Gert J Ossenkoppele, Georg Stussi, Johan Maertens, Kees van Montfort, Bart J Biemond, Dimitri Breems, August Ferrant, Carlos Graux, Georgine E de Greef, C J M Halkes, Mels Hoogendoorn, Rene M Hollestein, Mojca Jongen-Lavrencic, Mark D Levin, Arjan A van de Loosdrecht, Marinus van Marwijk Kooij, Yvette van Norden, Thomas Pabst, Harry C Schouten, Edo Vellenga, Gregor E G Verhoef, Okke de Weerdt, Pierre Wijermans, Jakob R Passweg, Bob Löwenberg
An urgent need for new treatment modalities is emerging in elderly patients with acute myeloid leukemia (AML). We hypothesized that targeting VEGF might furnish an effective treatment modality in this population. Elderly patients with AML were randomly assigned in this phase 2 study (n = 171) to receive standard chemotherapy (3 + 7) with or without bevacizumab at a dose of 10 mg/kg intravenously at days 1 and 15. In the second cycle, patients received cytarabine 1000 mg/m(2) twice daily on days 1-6 with or without bevacizumab...
December 6, 2012: Blood
Arjen Lommen, Henk J van der Kamp, Harrie J Kools, Martijn K van der Lee, Guido van der Weg, Hans G J Mol
A new alternative data processing tool set, metAlignID, is developed for automated pre-processing and library-based identification and concentration estimation of target compounds after analysis by comprehensive two-dimensional gas chromatography with mass spectrometric detection. The tool set has been developed for and tested on LECO data. The software is developed to run multi-threaded (one thread per processor core) on a standard PC (personal computer) under different operating systems and is as such capable of processing multiple data sets simultaneously...
November 9, 2012: Journal of Chromatography. A
Armando G Villaseñor, April Wong, Ada Shao, Ankur Garg, Timothy J Donohue, Andreas Kuglstatter, Seth F Harris
Focused acoustic energy allows accurate and precise liquid transfer on scales from picolitre to microlitre volumes. This technology was applied in protein crystallization, successfully transferring a diverse set of proteins as well as hundreds of precipitant solutions from custom and commercial crystallization screens and achieving crystallization in drop volumes as small as 20 nl. Only higher concentrations (>50%) of 2-methyl-2,4-pentanediol (MPD) appeared to be systematically problematic in delivery. The acoustic technology was implemented in a workflow, successfully reproducing active crystallization systems and leading to the discovery of crystallization conditions for previously uncharacterized proteins...
August 2012: Acta Crystallographica. Section D, Biological Crystallography
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