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Morsal Samim, Timothy H Mungroop, Mohammed AbuHilal, Cas J Isfordink, Quintus I Molenaar, Marcel J van der Poel, Thomas A Armstrong, Arjun S Takhar, Neil W Pearce, John N Primrose, Scott Harris, Helena M Verkooijen, Thomas M van Gulik, Jeroen Hagendoorn, Olivier R Busch, Colin D Johnson, Marc G Besselink
BACKGROUND: Several studies advise the use of risk models when counseling patients for hepato-pancreato-biliary (HPB) surgery, but studies comparing these models to the surgeons' assessment are lacking. The aim of this study was to assess whether risk prediction models outperform surgeons' assessment for the risk of complications in HPB surgery. METHODS: This prospective study included adult patients scheduled for HPB surgery in three centers in the UK and the Netherlands...
April 17, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
James Rourke, Shabnam Asghari, Oliver Hurley, Mohamed Ravalia, Michael Jong, Wendy Graham, Wanda Parsons, Norah Duggan, Danielle O'Keefe, Scott Moffatt, Katherine Stringer, Carolyn Sturge Sparkes, Janelle Hippe, Kristin Harris Walsh, Donald McKay, Asoka Samarasena
INTRODUCTION: Rural recruitment and retention of physicians is a global issue. The Faculty of Medicine at Memorial University of Newfoundland, Canada, was established as a rural-focused medical school with a social accountability mandate that aimed to meet the healthcare needs of a sparse population distributed over a large landmass as well as the needs of other rural and remote areas of Canada. This study aimed to assess whether Memorial medical degree (MD) and postgraduate (PG) programs were effective at producing physicians for their province and rural physicians for Canada compared with other Canadian medical schools...
March 2018: Rural and Remote Health
Marissa R Cabay, Jasmine C Harris, Scott A Shippy
The fruit fly is a frequently used model system with a high degree of human disease-related genetic homology. The quantitative chemical analysis of fruit fly tissues and hemolymph uniquely brings chemical signaling and compositional information to fly experimentation. The work here explores the impact of measured chemical content of hemolymph with three aspects of sample collection and preparation. Cellular content of hemolymph was quantitated and removed to determine hemolymph composition changes for seven primary amine analytes...
April 3, 2018: Analytical Chemistry
N A Jocelyn, P A Harris, N J Menzies-Gow
BACKGROUND: The oral sugar test (OST) is used to identify equine insulin dysregulation (ID); however only a dose of 0.15 mL/kg bwt corn syrup has been evaluated. OBJECTIVES: To determine the effect of varying the dose of corn syrup on insulin and glucose response to the OST and the test's ability to distinguish between ponies with a history of laminitis (PL) and without laminitis (NL). STUDY DESIGN: Randomised crossover experiment. METHODS: After an overnight fast, in a three-way randomised crossover study with a 7-day washout, 0...
March 5, 2018: Equine Veterinary Journal
Max P L van der Sijp, Inger B Schipper, Stefan B Keizer, Pieta Krijnen, Arthur H P Niggebrugge
BACKGROUND: The Direct Anterior Approach (DAA) is an alternative approach to the currently most used Lateral Approach (LA) for hip replacement in femoral neck fracture patients. Compared to the LA, the DAA minimizes soft tissue damage. Sparing muscle tissue may facilitate early and improved postoperative mobility. It may also be associated with fewer complications, increased quality of life and lower 1-year mortality. The aim of this study is to compare postoperative complications, hip function and patient mobility after hemiarthroplasty via the anterior or lateral approach following a displaced femoral neck fracture...
August 23, 2017: BMC Musculoskeletal Disorders
Charlotte A Ruys, Monique van de Lagemaat, Martijn Jj Finken, Harrie N Lafeber
Background: Early nutritional interventions may modulate health risks in preterm-born infants. Previously, we showed that preterm-born infants fed an isocaloric protein- and mineral-enriched postdischarge formula (PDF) from term age to 6-mo corrected age (CA) gained more lean mass than did those fed term formula (TF). Long-term follow-up of randomized nutritional trials is important to test the hypothesis that short-term positive effects on health are sustainable.Objective: The aim of this follow-up study was to compare body size, body composition, and metabolic health at age 8 y in preterm-born children who were randomly assigned to receive either PDF or TF from term age until 6-mo CA...
August 2017: American Journal of Clinical Nutrition
Marco Grisi, Franck Vincent, Beatrice Volpe, Roberto Guidetti, Nicola Harris, Armin Beck, Giovanni Boero
Nuclear magnetic resonance (NMR) spectroscopy enables non-invasive chemical studies of intact living matter. However, the use of NMR at the volume scale typical of microorganisms is hindered by sensitivity limitations, and experiments on single intact organisms have so far been limited to entities having volumes larger than 5 nL. Here we show NMR spectroscopy experiments conducted on single intact ova of 0.1 and 0.5 nL (i.e. 10 to 50 times smaller than previously achieved), thereby reaching the relevant volume scale where life development begins for a broad variety of organisms, humans included...
March 20, 2017: Scientific Reports
Jeanette K Doorduijn, Gustaaf W van Imhoff, Bronno van der Holt, Harry C Schouten, Martijn R Schaafsma, Marius A MacKenzie, Joke W Baars, Marie José Kersten, Pieternella J Lugtenburg, Martin J van den Bent, Roelien H Enting, Fokje M Spoelstra, Philip Poortmans, Jacoline E C Bromberg
The prognosis of central nervous system (CNS) relapse of systemic non-Hodgkin lymphoma is poor with 1-year survival historically at 0% to 20%. Aiming to improve these results, we performed a multicenter phase 2 study in patients with a CNS relapse, with or without concurrent systemic relapse. Treatment consisted of 2 cycles of R-DHAP alternating with high-dose methotrexate (MTX) and was combined with intrathecal rituximab. Responding patients received a third R-DHAP-MTX cycle followed by busulfan and cyclophosphamide myeloablative therapy and autologous stem cell transplantation...
December 2017: Hematological Oncology
Joan E Walter, Marjolein A Heuvelmans, Pim A de Jong, Rozemarijn Vliegenthart, Peter M A van Ooijen, Robin B Peters, Kevin Ten Haaf, Uraujh Yousaf-Khan, Carlijn M van der Aalst, Geertruida H de Bock, Willem Mali, Harry J M Groen, Harry J de Koning, Matthijs Oudkerk
BACKGROUND: US guidelines now recommend lung cancer screening with low-dose CT for high-risk individuals. Reports of new nodules after baseline screening have been scarce and are inconsistent because of differences in definitions used. We aimed to identify the occurrence of new solid nodules and their probability of being lung cancer at incidence screening rounds in the Dutch-Belgian Randomized Lung Cancer Screening Trial (NELSON). METHODS: In the ongoing, multicentre, randomised controlled NELSON trial, between Dec 23, 2003, and July 6, 2006, 15 822 participants who had smoked at least 15 cigarettes a day for more than 25 years or ten cigarettes a day for more than 30 years and were current smokers, or had quit smoking less than 10 years ago, were enrolled and randomly assigned to receive either screening with low-dose CT (n=7915) or no screening (n=7907)...
July 2016: Lancet Oncology
Mehmet Faruk Çatma, Serhan Ünlü, Alper Öztürk, Atıf M Aksekili, Önder Ersan, Yalım Ateş
PURPOSE: The purpose of this study was to compare two distinct fixation methods for a total hip replacement performed via transverse femoral shortening osteotomy for patients with severe hip dysplasia. METHODS: In this retrospective study we compared two fixation methods for total hip replacement of 78 hips in 76 patients exhibiting Crowe type IV developmental hip dysplasia (DDH). The hip replacements were performed via a transverse femoral shortening osteotomy and carried out between September 2009 and December 2013...
November 2016: International Orthopaedics
Kellie A Charles, Benjamin D W Harris, Carol R Haddad, Stephen J Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J Gill, Michael Back, David Veivers, Thomas Eade
BACKGROUND: Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clinical outcomes in a heterogeneous cohort of HNSCC cancer patients. METHODS: We performed a retrospective analysis to identify associations between NLR and clinicopathological features to recurrence free survival (RFS) and overall survival (OS)...
February 18, 2016: BMC Cancer
Claire L Jackson, Laura Behan, Samuel A Collins, Patricia M Goggin, Elizabeth C Adam, Janice L Coles, Hazel J Evans, Amanda Harris, Peter Lackie, Samantha Packham, Anton Page, James Thompson, Woolf T Walker, Claudia Kuehni, Jane S Lucas
Diagnosis of primary ciliary dyskinesia (PCD) lacks a "gold standard" test and is therefore based on combinations of tests including nasal nitric oxide (nNO), high-speed video microscopy analysis (HSVMA), genotyping and transmission electron microscopy (TEM). There are few published data on the accuracy of this approach.Using prospectively collected data from 654 consecutive patients referred for PCD diagnostics we calculated sensitivity and specificity for individual and combination testing strategies. Not all patients underwent all tests...
March 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Soroush Ardekani, Harry A Scott, Sharad Gupta, Shane Eum, Xiao Yang, Alexander R Brunelle, Sean M Wilson, Umar Mohideen, Kaustabh Ghosh
Nitroglycerin (NTG) markedly enhances nitric oxide (NO) bioavailability. However, its ability to mimic the anti-inflammatory properties of NO remains unknown. Here, we examined whether NTG can suppress endothelial cell (EC) activation during inflammation and developed NTG nanoformulation to simultaneously amplify its anti-inflammatory effects and ameliorate adverse effects associated with high-dose NTG administration. Our findings reveal that NTG significantly inhibits human U937 cell adhesion to NO-deficient human microvascular ECs in vitro through an increase in endothelial NO and decrease in endothelial ICAM-1 clustering, as determined by NO analyzer, microfluorimetry, and immunofluorescence staining...
November 20, 2015: Scientific Reports
Cornelis Verhoef, Neil Singla, Greg Moneta, William Muir, Arjen Rijken, Harry Lockstadt, Johannes H W de Wilt, Albert O-Yurvati, Linda A Zuckerman, Paul Frohna, Robert J Porte
BACKGROUND: Fibrocaps, a ready-to-use, dry-powder fibrin sealant containing human plasma-derived thrombin and fibrinogen, is being developed as an adjunct for surgical hemostasis. MATERIALS AND METHODS: Safety and efficacy of Fibrocaps applied directly or by spray device, in combination with gelatin sponge, was compared with that of gelatin sponge-alone in two randomized, single-blind controlled trials: FC-002 US (United States) and FC-002 NL (the Netherlands). A total of 126 adult patients were randomized (Fibrocaps: n = 47 [FC-002 US], n = 39 [FC-002 NL]; gelatin sponge alone: n = 23 [FC-002 US], n = 17 [FC-002 NL)...
April 2015: Journal of Surgical Research
Nanda Horeweg, Joost van Rosmalen, Marjolein A Heuvelmans, Carlijn M van der Aalst, Rozemarijn Vliegenthart, Ernst Th Scholten, Kevin ten Haaf, Kristiaan Nackaerts, Jan-Willem J Lammers, Carla Weenink, Harry J Groen, Peter van Ooijen, Pim A de Jong, Geertruida H de Bock, Willem Mali, Harry J de Koning, Matthijs Oudkerk
BACKGROUND: The main challenge in CT screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer. Management protocols use thresholds for nodule size and growth rate to determine which nodules require additional diagnostic procedures, but these should be based on individuals' probabilities of developing lung cancer. In this prespecified analysis, using data from the NELSON CT screening trial, we aimed to quantify how nodule diameter, volume, and volume doubling time affect the probability of developing lung cancer within 2 years of a CT scan, and to propose and evaluate thresholds for management protocols...
November 2014: Lancet Oncology
Nanda Horeweg, Ernst Th Scholten, Pim A de Jong, Carlijn M van der Aalst, Carla Weenink, Jan-Willem J Lammers, Kristiaan Nackaerts, Rozemarijn Vliegenthart, Kevin ten Haaf, Uraujh A Yousaf-Khan, Marjolein A Heuvelmans, Erik Thunnissen, Matthijs Oudkerk, Willem Mali, Harry J de Koning
BACKGROUND: Low-dose CT screening is recommended for individuals at high risk of developing lung cancer. However, CT screening does not detect all lung cancers: some might be missed at screening, and others can develop in the interval between screens. The NELSON trial is a randomised trial to assess the effect of screening with increasing screening intervals on lung cancer mortality. In this prespecified analysis, we aimed to assess screening test performance, and the epidemiological, radiological, and clinical characteristics of interval cancers in NELSON trial participants assigned to the screening group...
November 2014: Lancet Oncology
Amanda Harris, Esther Bhullar, Kerry Gove, Rhiannon Joslin, Jennifer Pelling, Hazel J Evans, Woolf T Walker, Jane S Lucas
BACKGROUND: Nasal nitric oxide (nNO) levels are very low in primary ciliary dyskinesia (PCD) and it is used as a screening test. METHODS: We assessed the reliability and usability of a hand-held analyser in comparison to a stationary nitric oxide (NO) analyser in 50 participants (15 healthy, 13 PCD, 22 other respiratory diseases; age 6-79 years). Nasal NO was measured using a stationary NO analyser during a breath-holding maneuver, and using a hand-held analyser during tidal breathing, sampling at 2 ml/sec or 5 ml/sec...
2014: BMC Pulmonary Medicine
Muriel Thomas, Lydie Lemonnier, Vincent Gulmans, Lutz Naehrlich, François Vermeulen, Harry Cuppens, Carlo Castellani, Aleksandra Norek, Kris De Boeck
BACKGROUND: Cystic fibrosis (CF) spans a wide spectrum. Therefore, benchmarking between registries implies comparing similar cohorts. OBJECTIVE AND METHODS: Explore patient characteristics in Belgian (B), French (F), German (G) and Dutch (NL) registries (total N=13,122) and determine whether they fulfill predefined diagnostic criteria. RESULTS: Using as case definition sweat chloride >60mmol/L or 2 CFTR mutations identified, CF diagnosis was not documented in 2...
May 2014: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Firdaus A A Mohamed Hoesein, Michael Schmidt, Onno M Mets, Hester A Gietema, Jan-Willem J Lammers, Pieter Zanen, Harry J de Koning, Carlijn van der Aalst, Matthijs Oudkerk, Rozemarijn Vliegenthart, Ivana Isgum, Mathias Prokop, Bram van Ginneken, Eva M van Rikxoort, Pim A de Jong
BACKGROUND: Finding phenotypes within COPD patients may prove imperative for optimizing treatment and prognosis. We hypothesized that it would be possible to discriminate emphysematous, large airway wall thickening and small airways disease dominant phenotypes. METHODS: Inspiratory and expiratory CTs were performed in 1140 male smokers without or with mild COPD to quantify emphysema, airway wall thickness and air trapping. Spirometry, residual volume to total lung capacity (RV/TLC) and diffusion capacity (Kco) were measured...
January 2014: Respiratory Medicine
N J Menzies-Gow, H Wray, S R Bailey, P A Harris, J Elliott
REASONS FOR PERFORMING STUDY: The mechanisms underlying predisposition to pasture-associated laminitis remain unclear; chronic inflammation is implicated, and this may be exacerbated by physical inactivity. OBJECTIVES: To determine whether exercise affects the inflammatory profile of normal and previously laminitic ponies. STUDY DESIGN: Prospective case-control study. METHODS: The short (1 day) and longer term (14 days) effects of low intensity (10 min walking and 5 min trotting) exercise on plasma inflammatory marker concentrations in normal (NL) and previously laminitic (PL) nonobese ponies (n = 6/group) was determined...
May 2014: Equine Veterinary Journal
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