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https://www.readbyqxmd.com/read/29769262/a-new-molecular-assay-and-genomic-complexity-predict-outcome-in-conventional-and-leukemic-non-nodal-mantle-cell-lymphoma
#1
Guillem Clot, Pedro Jares, Eva Giné, Alba Navarro, Cristina Royo, Magda Pinyol, David Martín-Garcia, Santiago Demajo, Blanca Espinet, Antonio Salar, Ana Ferrer, Ana Muntañola, Marta Aymerich, Hilka Rauert-Wunderlich, Elaine S Jaffe, Joseph M Connors, Randy D Gascoyne, Jan Delabie, Armando López-Guillermo, German Ott, George W Wright, Louis M Staudt, Andreas Rosenwald, David W Scott, Lisa M Rimsza, Sílvia Beà, Elías Campo
Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy but some patients have a very indolent evolution. This heterogeneous course is related, in part, to the different biological characteristics of conventional MCL (cMCL) and the distinct subgroup of leukemic non-nodal MCL (nnMCL). Robust criteria to distinguish these MCL subtypes and additional biological parameters that influence their evolution are not well defined. Herein, we describe a novel molecular assay that reliably distinguishes cMCL and nnMCL using blood samples...
May 16, 2018: Blood
https://www.readbyqxmd.com/read/29761220/transcriptomic-analysis-of-the-harvested-endothelial-cells-in-a-swine-model-of-mechanical-thrombectomy
#2
Nasren Jaff, Rikard Grankvist, Lars Muhl, Arvin Chireh, Mikael Sandell, Stefan Jonsson, Fabian Arnberg, Ulf Eriksson, Staffan Holmin
PURPOSE: In mechanical thrombectomy (MT) for ischemic stroke, endothelial cells (ECs) from intracranial blood vessels adhere to the stent retriever device and can be harvested. However, understanding the molecular biology and the role of the endothelium in different pathological conditions remains insufficient. The purpose of the study was to characterize and analyze the molecular aspect of harvested ECs using cell culture and transcriptomic techniques in an MT swine model relevant to clinical ischemic stroke...
May 14, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29760219/detectable-high-sensitivity-cardiac-troponin-within-the-population-reference-interval-conveys-high-5-year-cardiovascular-risk-an-observational-study
#3
Martin P Than, Sally J Aldous, Richard W Troughton, Christopher J Pemberton, A Mark Richards, Christopher M A Frampton, Christopher M Florkowski, Peter M George, Samantha Bailey, Joanna M Young, Louise Cullen, Jaimi H Greenslade, William A Parsonage, Brendan M Everett, W Frank Peacock, Allan S Jaffe, John W Pickering
BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit of detection and < upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality. METHODS: A prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29757723/ct-and-mr-imaging-features-of-artificial-urinary-sphincters-penile-prostheses-and-other-devices-in-the-male-lower-genitourinary-tract
#4
Elizabeth T Chorney, Parvati Ramchandani, William I Jaffe, Evan S Siegelman
Urinary incontinence and erectile dysfunction are relatively common conditions in the aging male population. Surgical interventions for urinary incontinence include placement of an artificial urinary sphincter (AUS), perineal sling, or sacral nerve stimulator and injections of periurethral bulking agents. Erectile dysfunction can be treated surgically with placement of a penile prosthesis. The complications of these devices can be broadly categorized as device component malposition, malfunction, and infection...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29756663/coupling-trapped-ion-mobility-spectrometry-to-mass-spectrometry-tims-tof-ms-vs-tims-ft-icr-ms
#5
Lilian V Tose, Paolo Benigni, Dennys Leyva, Abigail Sundberg, César E Ramírez, Mark E Ridgeway, Melvin A Park, Wanderson Romão, Rudolf Jaffé, Francisco Fernandez-Lima
RATIONALE: There is a need for fast, post-ionization separation during the analysis of complex mixtures. In this study, we evaluate the use of a high-resolution mobility analyzer with high resolution and ultra-high-resolution mass spectrometry for unsupervised molecular feature detection. Goals include the study of the reproducibility of TIMS across platforms, applicability range and potential challenges during routine analysis. METHODS: A TIMS analyzer was coupled to TOF-MS and to an FT-ICR MS for the analysis of single charge species in the m/z 150-800 range of a complex mixture (Suwannee River Fulvic Acid Standard)...
May 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29753264/perineural-dexamethasone-successfully-prolongs-adductor-canal-block-when-assessed-by-objective-pinprick-sensory-testing-a-prospective-randomized-dose-dependent-placebo-controlled-equivalency-trial
#6
James D Turner, Daryl S Henshaw, Robert S Weller, J Douglas Jaffe, Christopher J Edwards, J Wells Reynolds, Gregory B Russell, Sean W Dobson
STUDY OBJECTIVE: To determine whether perineural dexamethasone prolongs peripheral nerve blockade (PNB) when measured objectively; and to determine if a 1 mg and 4 mg dose provide equivalent PNB prolongation compared to PNB without dexamethasone. SETTING: Multiple studies have reported that perineural dexamethasone added to local anesthetics (LA) can prolong PNB. However, these studies have relied on subjective end-points to quantify PNB duration. The optimal dose remains unknown...
May 8, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29748435/end-of-treatment-and-serial-pet-imaging-in-primary-mediastinal-b-cell-lymphoma-following-dose-adjusted-epoch-r-a-paradigm-shift-in-clinical-decision-making
#7
Christopher Melani, Ranjana Advani, Mark Roschewski, Kelsey M Walters, Clara C Chen, Lucia Baratto, Mark A Ahlman, Milos D Miljkovic, Seth M Steinberg, Jessica Lam, Margaret Shovlin, Kieron Dunleavy, Stefania Pittaluga, Elaine S Jaffe, Wyndham H Wilson
Dose-adjusted-EPOCH-R obviates the need for radiotherapy in most patients with primary mediastinal B-cell lymphoma. End-of-treatment PET, however, does not accurately identify patients at risk of treatment failure, thereby confounding clinical decision making. To define the role of PET in primary mediastinal B-cell lymphoma following dose-adjusted-EPOCH-R, we extended enrollment and follow-up on our published phase II trial and independent series. Ninety-three patients received dose-adjusted-EPOCH-R without radiotherapy...
May 10, 2018: Haematologica
https://www.readbyqxmd.com/read/29737180/copeptin-to-rule-out-myocardial-infarction-in-blacks-versus-caucasians
#8
Neil Beri, Lori B Daniels, Allan Jaffe, Christian Mueller, Inder Anand, W Frank Peacock, Judd E Hollander, Christopher DeFilippi, Donald Schreiber, James McCord, Alexander T Limkakeng, Alan H B Wu, Fred S Apple, Deborah B Diercks, John T Nagurney, Richard M Nowak, Chad M Cannon, Paul Clopton, Sean-Xavier Neath, Robert H Christenson, Christopher Hogan, Gary Vilke, Alan Maisel
BACKGROUND: Copeptin in combination with troponin has been shown to have incremental value for the early rule-out of myocardial infarction, but its performance in Black patients specifically has never been examined. In light of a potential for wider use, data on copeptin in different relevant cohorts are needed. This is the first study to determine whether copeptin is equally effective at ruling out myocardial infarction in Black and Caucasian races. METHODS: This analysis of the CHOPIN trial included 792 Black and 1075 Caucasian patients who presented to the emergency department with chest pain and had troponin-I and copeptin levels drawn...
May 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29730377/adventitial-drug-delivery-of-dexamethasone-to-improve-primary-patency-in-the-treatment-of-superficial-femoral-and-popliteal-artery-disease-12-month-results-from-the-dance-clinical-trial
#9
Mahmood K Razavi, Dennis Donohoe, Ralph B D'Agostino, Michael R Jaff, George Adams
OBJECTIVES: This study was designed to evaluate outcomes of adventitial dexamethasone delivery adjunctive to standard endovascular revascularization in femoropopliteal peripheral artery disease. BACKGROUND: Drug-coated balloons and drug-eluting stents improve patency of endovascular interventions with passive diffusion of antiproliferative drugs. Adventitial dexamethasone delivery targets the initial triggers of the inflammatory reaction to injury, thus potentially providing a potent antirestenotic strategy...
April 27, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29726328/scientists-and-physicians-run-for-office-in-the-usa
#10
Susan Jaffe
No abstract text is available yet for this article.
April 28, 2018: Lancet
https://www.readbyqxmd.com/read/29720485/consensus-recommendations-for-the-diagnosis-and-clinical-management-of-rosai-dorfman-destombes-disease
#11
Oussama Abla, Eric Jacobsen, Jennifer Picarsic, Zdenka Krenova, Ronald Jaffe, Jean-Francois Emile, Benjamin H Durham, Jorge Braier, Frédéric Charlotte, Jean Donadieu, Fleur Cohen Aubart, Carlos Rodriguez-Galindo, Carl Allen, James A Whitlock, Sheila Weitzman, Kenneth L McClain, Julien Haroche, Eli L Diamond
Rosai-Dorfman-Destombes disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by accumulation of activated histiocytes within affected tissues. RDD, which now belongs to the R group of the 2016 revised histiocytoses classification, is a widely heterogeneous entity with a range of clinical phenotypes occurring in isolation or in association with autoimmune or malignant diseases. Recent studies have found NRAS, KRAS, MAP2K1 and ARAF mutations in lesional tissues, raising the possibility of a clonal origin in some forms of RDD...
May 2, 2018: Blood
https://www.readbyqxmd.com/read/29718715/treatment-outcomes-among-a-cohort-of-african-american-buprenorphine-patients-follow-up-at-12-months
#12
Laura B Monico, Jan Gryczynski, Robert P Schwartz, Jerome H Jaffe, Kevin E O'Grady, Shannon Gwin Mitchell
BACKGROUND: Although buprenorphine/naloxone (bup/nal) is well-established as a safe and effective treatment for opioid use disorders (OUDs), there are few studies reporting 12-month outcomes of patients receiving bup/nal in formerly drug-free outpatient programs. OBJECTIVES: To examine 12-month outcomes by bup/nal treatment enrollment status among a cohort of African American patients enrolled in a clinical trial. METHODS: This analysis builds upon a randomized trial of 300 opioid-dependent African American bup/nal patients in two outpatient programs in Baltimore, MD...
May 2, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29709396/rivaroxaban-plus-percutaneous-catheter-directed-treatment-for-a-patient-with-massive-pulmonary-embolism-and-colporrhagia
#13
Wuchao Wang
Massive pulmonary embolism (PE) is defined by acute PE with sustained systemic arterial hypotension that is below 90 mm Hg for at least 15 min or requires inotropic agents (Jaff et al., 2011). For patients with absolute contraindications to thrombolysis, interventional treatment requires the removal of obstructing thrombi from the main pulmonary arteries to facilitate RV recovery and improve symptoms and survival (European Respiratory Society et al., 2014). For patients with acute PE, anticoagulation is recommended, with the objective of preventing both early death and recurrent symptomatic or fatal VTE...
April 19, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29708913/case-report-of-an-awake-craniotomy-in-a-patient-with-eisenmenger-syndrome
#14
Boris D Heifets, Erin Crawford, Ethan Jackson, Jessica Brodt, Richard A Jaffe, Mark A Burbridge
We present a detailed report of an awake craniotomy for recurrent third ventricular colloid cyst in a patient with severe pulmonary arterial hypertension in the setting of Eisenmenger syndrome, performed 6 weeks after we managed the same patient for a more conservative procedure. This patient has a high risk of perioperative mortality and may be particularly susceptible to perioperative hemodynamic changes or fluid shifts. The risks of general anesthesia induction and emergence must be balanced against the risks inherent in an awake craniotomy on a per case basis...
May 1, 2018: A&A practice
https://www.readbyqxmd.com/read/29707481/brugada-type-electrocardiogram-changes-associated-with-nitroprusside-toxicity
#15
Jonathan T Jaffe, Lee-Gardie Jean, Richard J Murray
No abstract text is available yet for this article.
March 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29700951/recommended-treatment-protocols-to-improve-management-of-hypertension-globally-a-statement-by-resolve-to-save-lives-and-the-world-hypertension-league-whl
#16
Marc G Jaffe, Thomas R Frieden, Norman R C Campbell, Kunihiro Matsushita, Lawrence J Appel, Daniel T Lackland, Xin Hua Zhang, Arumugam Muruganathan, Paul K Whelton
No abstract text is available yet for this article.
April 27, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29691970/scai-consensus-guidelines-for-device-selection-in-femoral-popliteal-arterial-interventions
#17
Dmitriy N Feldman, Ehrin J Armstrong, Herbert D Aronow, Osvaldo S Gigliotti, Michael R Jaff, Andrew J Klein, Sahil A Parikh, Anand Prasad, Kenneth Rosenfield, Mehdi H Shishehbor, Rajesh V Swaminathan, Christopher J White
No abstract text is available yet for this article.
April 24, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29687107/multiparameter-cell-tracking-intrinsic-cytometry-for-single-cell-characterization
#18
N Apichitsopa, A Jaffe, J Voldman
An abundance of label-free microfluidic techniques for measuring cell intrinsic markers exists, yet these techniques are seldom combined because of integration complexity such as restricted physical space and incompatible modes of operation. We introduce a multiparameter intrinsic cytometry approach for the characterization of single cells that combines ≥2 label-free measurement techniques onto the same platform and uses cell tracking to associate the measured properties to cells. Our proof-of-concept implementation can measure up to five intrinsic properties including size, deformability, and polarizability at three frequencies...
May 15, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29686002/global-implications-of-blood-pressure-thresholds-and-targets-guideline-conversations-from-the-world-hypertension-league
#19
Daniel T Lackland, Lawrence J Beilin, Norm R C Campbell, Marc G Jaffe, Marcelo Orias, C Venkata Ram, Michael A Weber, Xin-Hua Zhang
No abstract text is available yet for this article.
April 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29686001/biological-sex-modulates-the-adrenal-and-blood-pressure-responses-to-angiotensin-ii
#20
Mohammad Zaki Shukri, Jia Wei Tan, Worapaka Manosroi, Luminita H Pojoga, Alicia Rivera, Jonathan S Williams, Ellen W Seely, Gail K Adler, Iris Z Jaffe, Richard H Karas, Gordon H Williams, Jose R Romero
The relationship between biological sex and aldosterone on blood pressure (BP) is unclear. We hypothesized that sex would modify the interaction between aldosterone and vascular responses to salt intake and angiotensin II (AngII). To test this hypothesis, in 1592 subjects from the well-controlled Hypertensive Pathotype cohort, we compared responses of women and men to chronic (BP and aldosterone levels in response to dietary salt) and acute (BP, renal plasma flow, and aldosterone responses to AngII infusion) manipulations...
June 2018: Hypertension
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