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https://www.readbyqxmd.com/read/29346055/pathology-in-practice
#1
Valerie M Wong, Michael H Jaffe
No abstract text is available yet for this article.
February 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29343532/clinical-laboratory-practice-recommendations-for-the-use-of-cardiac-troponin-in-acute-coronary-syndrome-expert-opinion-from-the-academy-of-the-american-association-for-clinical-chemistry-and-the-task-force-on-clinical-applications-of-cardiac-bio-markers-of
#2
Alan H B Wu, Robert H Christenson, Dina N Greene, Allan S Jaffe, Peter A Kavsak, Jordi Ordonez-Llanos, Fred S Apple
This document is an essential companion to the third iteration of the National Academy of Clinical Biochemistry [NACB,8 now the American Association for Clinical Chemistry (AACC) Academy] Laboratory Medicine Practice Guidelines (LMPG) on cardiac markers. The expert consensus recommendations were drafted in collaboration with the International Federation of Clinical Chemistry and Laboratory Medicine Task Force on Clinical Applications of Bio-Markers (IFCC TF-CB). We determined that there is sufficient clinical guidance on the use of cardiac troponin (cTn) testing from clinical practice groups...
January 17, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29343291/trends-in-the-performance-of-quality-indicators-for-diabetes-care-in-the-community-and-in-diabetes-related-health-status-an-israeli-ecological-study
#3
Ronit Calderon-Margalit, Michal Cohen-Dadi, Dana Opas, Dena H Jaffe, Jacob Levine, Arie Ben-Yehuda, Ora Paltiel, Orly Manor
BACKGROUND: Israel is one of the few countries that have a national program for quality assessment of community healthcare. We aimed to evaluate whether improved performance in diabetes care was associated with improved health of diabetic patients on a national level. METHODS: We conducted a nationwide ecological study estimating improvements in diabetes-related quality indicators and health outcomes. We estimated both correlations between composite measures of diabetes-related quality indicators and selected outcomes, and assessed through a joinpoint analysis whether trends in selected outcomes changed 4 years after the inception of the national program...
January 17, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29341896/luteinizing-hormone-signaling-phosphorylates-and-activates-the-cyclic-gmp-phosphodiesterase-pde5-in-mouse-ovarian-follicles-contributing-an-additional-component-to-the-hormonally-induced-decrease-in-cyclic-gmp-that-reinitiates-meiosis
#4
Jeremy R Egbert, Siu-Pok Yee, Laurinda A Jaffe
Prior to birth, oocytes within mammalian ovarian follicles initiate meiosis, but then arrest in prophase until puberty, when with each reproductive cycle, one or more follicles are stimulated by luteinizing hormone (LH) to resume meiosis in preparation for fertilization. Within preovulatory follicles, granulosa cells produce high levels of cGMP, which diffuses into the oocyte to maintain meiotic arrest. LH signaling restarts meiosis by rapidly lowering the levels of cGMP in the follicle and oocyte. Part of this decrease is mediated by the dephosphorylation and inactivation the NPR2 guanylyl cyclase in response to LH, but the mechanism for the remainder of the cGMP decrease is unknown...
January 13, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29334617/chains-of-risk-for-alcohol-use-disorder-mediators-of-exposure-to-neighborhood-deprivation-in-early-and-middle-childhood
#5
Katherine J Karriker-Jaffe, Sara L Lönn, Won K Cook, Kenneth S Kendler, Kristina Sundquist
Our goal was to test a cascade model to identify developmental pathways, or chains of risk, from neighborhood deprivation in childhood to alcohol use disorder (AUD) in young adulthood. Using Swedish general population data, we examined whether exposure to neighborhood deprivation during early and middle childhood was associated with indicators of social functioning in adolescence and emerging adulthood, and whether these were predictive of AUD. Structural equation models showed exposure to neighborhood deprivation was associated with lower school achievement during adolescence, poor social functioning during emerging adulthood, and the development of AUD for both males and females...
January 12, 2018: Health & Place
https://www.readbyqxmd.com/read/29331273/meta-analyses-and-interpretation-of-troponin-values-in-heart-failure
#6
EDITORIAL
Allan S Jaffe, Wayne L Miller
No abstract text is available yet for this article.
January 3, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29326153/treatment-effect-of-drug-coated-balloons-is-durable-to-3-years-in-the-femoropopliteal-arteries-long-term-results-of-the-in-pact-sfa-randomized-trial
#7
Peter A Schneider, John R Laird, Gunnar Tepe, Marianne Brodmann, Thomas Zeller, Dierk Scheinert, Christopher Metzger, Antonio Micari, Ravish Sachar, Michael R Jaff, Hong Wang, Melissa S Hasenbank, Prakash Krishnan
BACKGROUND: Randomized controlled trials have reported favorable 1-year outcomes with drug-coated balloons (DCBs) for the treatment of symptomatic peripheral arterial disease when compared with standard percutaneous transluminal angioplasty (PTA). Evidence remains limited on the durability of the treatment effect with DCBs in the longer term. METHODS AND RESULTS: IN.PACT SFA is a single-blind, randomized trial (Randomized Trial of IN.PACT Admiral Paclitaxel-Coated Percutaneous Transluminal Angioplasty [PTA] Balloon Catheter vs Standard PTA for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery [SFA] and/or Proximal Popliteal Artery [PPA]) that enrolled 331 patients with symptomatic (Rutherford 2-4) femoropopliteal lesions up to 18 cm in length...
January 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29323193/rapid-thermal-processing-to-enhance-steel-toughness
#8
V K Judge, J G Speer, K D Clarke, K O Findley, A J Clarke
Quenching and Tempering (Q&T) has been utilized for decades to alter steel mechanical properties, particularly strength and toughness. While tempering typically increases toughness, a well-established phenomenon called tempered martensite embrittlement (TME) is known to occur during conventional Q&T. Here we show that short-time, rapid tempering can overcome TME to produce unprecedented property combinations that cannot be attained by conventional Q&T. Toughness is enhanced over 43% at a strength level of 1...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321450/microfluidic-paper-based-analytical-devices-for-determination-of-creatinine-in-urine-samples
#9
Suphanan Sununta, Poomrat Rattanarat, Orawon Chailapakul, Narong Praphairaksit
Simple, low-cost and portable microfluidic paper-based analytical devices (μPADs) for determination of creatinine in urine samples were developed. The methodology was based on Jaffé reaction between the creatinine and picric acid in alkaline conditions, generating a colorimetric creatinine-alkaline picrate complex. The product exhibits an orange color that is clearly visible on the μPADs. The color intensity of the complex, which is indicative of the concentration of creatinine, is then quantitatively determined using ImageJ software...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29319684/mapping-the-global-influence-of-published-research-on-industry-and-innovation
#10
Osmat A Jefferson, Adam Jaffe, Doug Ashton, Ben Warren, Deniz Koellhofer, Uwe Dulleck, Aaron Ballagh, John Moe, Michael DiCuccio, Karl Ward, Geoff Bilder, Kevin Dolby, Richard A Jefferson
No abstract text is available yet for this article.
January 10, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29315303/genome-wide-comparison-of-ethiopian-leishmania-donovani-strains-reveals-differences-potentially-related-to-parasite-survival
#11
Arie Zackay, James A Cotton, Mandy Sanders, Asrat Hailu, Abedelmajeed Nasereddin, Alon Warburg, Charles L Jaffe
Leishmania donovani is the main cause of visceral leishmaniasis (VL) in East Africa. Differences between northern Ethiopia/Sudan (NE) and southern Ethiopia (SE) in ecology, vectors, and patient sensitivity to drug treatment have been described, however the relationship between differences in parasite genotype between these two foci and phenotype is unknown. Whole genomic sequencing (WGS) was carried out for 41 L. donovani strains and clones from VL and VL/HIV co-infected patients in NE (n = 28) and SE (n = 13)...
January 9, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29305092/comparing-analytical-outliers-and-the-percent-of-emergency-department-patients-with-results-above-the-99th-percentile-upper-reference-limit-for-2-conventional-and-one-high-sensitivity-troponin-assay
#12
Brad S Karon, Amy M Wockenfus, Katherine J Hartung, Renee J Scott, Steven D Carter, Allan S Jaffe
OBJECTIVES: We compared rates of analytical outliers, and percent of emergency department (ED) patients with cardiac troponin (cTn) values above the 99th percentile upper reference limit (URL), for two conventional and one high sensitivity cTn assay. METHODS: We measured 3008 samples from 1931 ED patients by Roche e411 4th generation Troponin T (cTnT); and Abbott STAT Troponin I (cTnI) and high sensitivity troponin I (hscTnI) on an Architect i2000. Within 24h of initial measurement, samples were aliquoted, re-centrifuged, and repeated in duplicate by all methods...
January 2, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29303724/us-children-s-health-insurance-program-in-jeopardy
#13
Susan Jaffe
No abstract text is available yet for this article.
December 23, 2018: Lancet
https://www.readbyqxmd.com/read/29296913/clinicopathologic-consensus-study-of-gray-zone-lymphoma-with-features-intermediate-between-dlbcl-and-classical-hl
#14
Monika Pilichowska, Stefania Pittaluga, Judith A Ferry, Jessica Hemminger, Hong Chang, Jennifer A Kanakry, Laurie H Sehn, Tatyana Feldman, Jeremy S Abramson, Athena Kritharis, Francisco J Hernandez-Ilizaliturri, Izidore S Lossos, Oliver W Press, Timothy S Fenske, Jonathan W Friedberg, Julie M Vose, Kristie A Blum, Deepa Jagadeesh, Bruce Woda, Gaurav K Gupta, Randy D Gascoyne, Elaine S Jaffe, Andrew M Evens
Gray zone lymphoma (GZL) is described as sharing features with classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL). However, there remains complexity in establishing diagnosis, delineating prognosis, and determining optimum therapy. Sixty-eight cases diagnosed as GZL across 15 North American academic centers were evaluated by central pathology review to achieve consensus. Of these, only 26 (38%) were confirmed as GZL. Morphology was critical to GZL consensus diagnosis (eg, tumor cell richness); immunohistochemistry showed universal B-cell derivation, frequent CD30 expression, and rare Epstein-Barr virus (EBV) positivity (CD20+, 83%; PAX5+, 100%; BCL6+, 20%; MUM1+, 100%; CD30+, 92%; EBV+, 4%)...
December 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29294900/characterizing-sexual-violence-in-intimate-relationships-an-examination-of-blame-attributions-and-rape-acknowledgment
#15
Anna E Jaffe, Anne L Steel, David DiLillo, Terri L Messman-Moore, Kim L Gratz
Rape by an intimate partner frequently involves a precedence of sexual consent between victim and perpetrator, often does not include the use of physical force, and may not fit societal definitions of rape. Given these unique characteristics, women who are assaulted by an intimate partner may be less likely to acknowledge the experience as a rape. In turn, they might make fewer blame attributions toward themselves and their perpetrators than victims of rape by a nonpartner. Consistent with these expectations, results from 208 community women reporting rape in adulthood revealed the presence of indirect effects of perpetrator type (nonpartner vs...
August 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29285955/novel-nitinol-stent-for-lesions-up-to-24-cm-in-the-superficial-femoral-and-proximal-popliteal-arteries-24-month-results-from-the-tigris-randomized-trial
#16
John R Laird, Thomas Zeller, Christian Loewe, Jack Chamberlin, Richard Begg, Peter A Schneider, Aravinda Nanjundappa, Frank Bunch, Scott Schultz, Stuart Harlin, Alexandra Lansky, Michael R Jaff
PURPOSE: To evaluate the safety and effectiveness of the TIGRIS stent for lesions up to 24 cm in the superficial femoral and proximal popliteal arteries (SFA/PPA). METHODS: This prospective, multicenter, randomized study enrolled 274 subjects at 36 sites in the United States and Europe. Subjects were randomly assigned in a 3:1 ratio to treatment with the TIGRIS stent (n=197; mean age 66.7±9.28 years; 141 men) or LifeStent (n=70; mean age 67.9±8.87 years; 49 men)...
December 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29278915/how-is-cardiac-troponin-released-from-injured-myocardium
#17
Johannes Mair, Bertil Lindahl, Ola Hammarsten, Christian Müller, Evangelos Giannitsis, Kurt Huber, Martin Möckel, Mario Plebani, Kristian Thygesen, Allan S Jaffe
Cardiac troponin I and cardiac troponin T are nowadays the criterion biomarkers for the laboratory diagnosis of acute myocardial infarction due to their very high sensitivities and specificities for myocardial injury. However, still many aspects of their degradation, tissue release and elimination from the human circulation are incompletely understood. Myocardial injury may be caused by a variety of different mechanisms, for example, myocardial ischaemia, inflammatory and immunological processes, trauma, drugs and toxins, and myocardial necrosis is preceded by a substantial reversible prelethal phase...
December 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29275398/helping-refugee-children-thrive-what-we-know-and-where-to-next
#18
Karen Zwi, Lisa Woodland, Sarah Mares, Santuri Rungan, Pamela Palasanthiran, Katrina Williams, Susan Woolfenden, Adam Jaffe
No abstract text is available yet for this article.
December 23, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29259114/mathematical-picture-language-program
#19
Arthur M Jaffe, Zhengwei Liu
We give an overview of our philosophy of pictures in mathematics. We emphasize a bidirectional process between picture language and mathematical concepts: abstraction and simulation. This motivates a program to understand different subjects, using virtual and real mathematical concepts simulated by pictures.
December 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29237722/pannexin-1-channels-as-an-unexpected-new-target-of-the-anti-hypertensive-drug-spironolactone
#20
Miranda E Good, Yu-Hsin Chiu, Ivan K Poon, Christopher B Medina, Joshua T Butcher, Suresh K Mendu, Leon J DeLalio, Alexander W Lohman, Norbert Leitinger, Eugene J Barrett, Ulrike M Lorenz, Bimal N Desai, Iris Z Jaffe, Douglas Bayliss, Brant E Isakson, Kodi S Ravichandran
Rationale: Resistant hypertension is a major health concern with unknown etiology. Spironolactone is an effective anti-hypertensive drug, especially for patients with resistant hypertension, and is considered by the World Health Organization (WHO) as an "essential" medication. Although spironolactone can act at the mineralocorticoid receptor (NR3C2), there is increasing evidence of mineralocorticoid receptor (MR)-independent effects of spironolactone. Objective: Here, we detail the unexpected discovery that pannexin 1 (Panx1) channels could be a relevant in vivo target of spironolactone...
December 13, 2017: Circulation Research
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