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https://www.readbyqxmd.com/read/28737566/high-flow-nasal-cannula-a-novel-approach-to-airway-management-in-awake-craniotomies
#1
Sara C Smith, Mark Burbridge, Richard Jaffe
No abstract text is available yet for this article.
July 21, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28734494/bone-transport-versus-acute-shortening-for-the-management-of-infected-tibial-non-unions-with-bone-defects
#2
Kevin Tetsworth, Cengiz Sen, John E Herzenberg, Matthew Jaffe, Dean C Maar, Vaida Glatt, Dror Paley, Erik Hohmann
INTRODUCTION: This study compared bone transport to acute shortening/lengthening in a series of infected tibial segmental defects for infected tibial non-union. METHODS: In a retrospective comparative study 42 patients treated for infected tibial non-union with segmental bone loss measuring between 3 and 10cm were included. Group A was treated with bone transport and Group B with acute shortening/lengthening. All patients were treated by Ilizarov methods for gradual correction as bi-focal or tri-focal treatment; the treating surgeon selected either transport or acute shortening based on clinical considerations...
July 12, 2017: Injury
https://www.readbyqxmd.com/read/28733516/my-week-jenny-jaffe
#3
Jenny Jaffe
Jenny Jaffe is a veterinarian who works on disease risk analysis and health surveillance at the Zoological Society of London. Here, she describes a recent week.
July 22, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28729250/stellarex-drug-coated-balloon-for-treatment-of-femoropopliteal-disease-12-month-outcomes-from-the-randomized-illumenate-pivotal-and-pharmacokinetic-studies
#4
Prakash Krishnan, Peter Faries, Khusrow Niazi, Ash Jain, Ravish Sachar, William B Bachinsky, Joseph A Cardenas, Martin Werner, Marianne Brodmann, J A Mustapha, Carlos I Mena-Hurtado, Michael R Jaff, Andrew H Holden, Sean P Lyden
Background -Drug-coated balloons (DCB) are a predominant revascularization therapy for symptomatic femoropopliteal artery disease. Due to differences in excipients, paclitaxel dose and coating morphologies, varying clinical outcomes have been observed with different DCBs. We report the results of two studies investigating the pharmacokinetic (PK) and clinical outcomes of a new DCB to treat femoropopliteal disease. Methods -In the ILLUMENATE Pivotal Study, 300 symptomatic patients (Rutherford class 2-4), were randomized to DCB (N=200) or standard angioplasty (PTA) (N=100)...
July 20, 2017: Circulation
https://www.readbyqxmd.com/read/28723859/determinants-of-follow-up-care-for-patients-with-celiac-disease
#5
Margot E Cohen, Ariel Jaffe, Carolyn B Strauch, Suzanne K Lewis, Benjamin Lebwohl, Peter H R Green
GOALS: This study aimed to investigate follow-up patterns among celiac disease (CD) patients. BACKGROUND: Gender factors are important in CD with women diagnosed more frequently than men despite equal seropositivity in screening studies. To determine if gender influences postdiagnosis care, we performed a retrospective cohort study investigating the impact of gender and mode of presentation on follow-up patterns after diagnosis. STUDY: The study included adults with biopsy-proven CD presenting to a single tertiary care center between 2005 and 2014...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28720073/heterogeneity-in-national-u-s-mortality-trends-within-heart-disease-subgroups-2000-2015
#6
Stephen Sidney, Charles P Quesenberry, Marc G Jaffe, Michael Sorel, Alan S Go, Jamal S Rana
BACKGROUND: The long-term downward national U.S. trend in heart disease-related mortality slowed substantially during 2011-2014 before turning upward in 2015. Examining mortality trends in the major subgroups of heart disease may provide insight into potentially more targeted and effective prevention and treatment approaches to promote favorable trajectories. We examined national trends between 2000 and 2015 in mortality attributed to major heart disease subgroups including ischemic heart disease, heart failure, and all other types of heart disease...
July 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28719430/high-sensitivity-cardiac-troponin-t-improves-the-diagnosis-of-perioperative-mi
#7
Jamie C Brown, Eslam Samaha, Srikar Rao, Mohammad A Helwani, Andreas Duma, Frank Brown, Brian F Gage, J Philip Miller, Allan S Jaffe, Fred S Apple, Mitchell G Scott, Peter Nagele
BACKGROUND: The diagnosis of myocardial infarction (MI) after noncardiac surgery has traditionally relied on using relatively insensitive contemporary cardiac troponin (cTn) assays. We hypothesized that using a recently introduced novel high-sensitivity cTnT (hscTnT) assay would increase the detection rate of perioperative MI. METHODS: In this ancillary study of the Vitamins in Nitrous Oxide trial, readjudicated incidence rates of myocardial injury (new isolated cTn elevation) and MI were compared when diagnosed by contemporary cTnI versus hscTnT...
July 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28716309/arginine-vasopressin-copeptin-and-the-development-of-relative-avp-deficiency-in-hemorrhagic-shock
#8
Carrie A Sims, Yuxia Guan, Meredith Bergey, Rebecca Jaffe, Lilias Holmes-Maguire, Niels Martin, Patrick Reilly
BACKGROUND: Arginine vasopressin (AVP) is critical for maintaining vasomotor tone and low levels have been associated with the development of irreversible shock. We investigated the clinical relationship between AVP, copeptin (the C-terminal fragment of the AVP precursor), and the development of relative AVP deficiency following hemorrhagic shock. METHODS: A prospective, observational study of 21 hypotensive (SBP<90 mmHg X 2) or presumptively bleeding trauma patients was conducted...
June 24, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28715558/prevalence-of-intracranial-aneurysm-in-women-with-fibromuscular-dysplasia-a-report-from-the-us-registry-for-fibromuscular-dysplasia
#9
Henry D Lather, Heather L Gornik, Jeffrey W Olin, Xiaokui Gu, Steven T Heidt, Esther S H Kim, Daniella Kadian-Dodov, Aditya Sharma, Bruce Gray, Michael R Jaff, Yung-Wei Chi, Pamela Mace, Eva Kline-Rogers, James B Froehlich
Importance: The prevalence of intracranial aneurysm in patients with fibromuscular dysplasia (FMD) is uncertain. Objective: To examine the prevalence of intracranial aneurysm in women diagnosed with FMD. Design, Setting, and Participants: This cross-sectional study included 669 women with intracranial imaging registered in the US Registry for Fibromuscular Dysplasia, an observational disease-based registry of patients with FMD confirmed by vascular imaging and currently enrolling at 14 participating US academic centers...
July 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28706488/postnatal-maturation-of-the-glomerular-filtration-rate-in-conventional-growing-piglets-as-potential-juvenile-animal-model-for-preclinical-pharmaceutical-research
#10
Elke Gasthuys, Mathias Devreese, Joske Millecam, Stanislas Sys, Katrien Vanderperren, Joris Delanghe, Johan Vande Walle, Marjolein Heyndrickx, Siska Croubels
Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation. Over the years, pigs were presented as a potential animal model, since they display a high degree of anatomical and physiological similarities with humans. To assess the suitability of piglets as a preclinical animal model for children, the ontogeny and maturation processes of several organ systems have to be unraveled and compared between both species...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28706364/prediction-of-preeclampsia-in-early-pregnancy-by-estimating-the-spot-urinary-albumin-creatinine-ratio
#11
Nupur Gupta, Taru Gupta, Deepti Asthana
OBJECTIVE: To assess whether a spot urinary albumin:creatinine ratio (ACR) measured before 20 weeks of gestation can predict subsequent development of preeclampsia. METHODS: The ACR was determined from midstream urine sample taken between 17 and 20 weeks of gestation. Urine albumin was measured by immunoturbidimetric method using commercially available kit (Beckman Coulter) through Beckman AU 480 fully automated biochemistry analyzer. Urine creatinine was measured by modified kinetic Jaffe reaction without deproteinization...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28701475/hif-activation-causes-synthetic-lethality-between-the-vhl-tumor-suppressor-and-the-ezh1-histone-methyltransferase
#12
Abhishek A Chakraborty, Eijiro Nakamura, Jun Qi, Amanda Creech, Jacob D Jaffe, Joshiawa Paulk, Jesse S Novak, Kshithija Nagulapalli, Samuel K McBrayer, Glenn S Cowley, Javier Pineda, Jiaxi Song, Yaoyu E Wang, Steven A Carr, David E Root, Sabina Signoretti, James E Bradner, William G Kaelin
Inactivation of the von Hippel-Lindau tumor suppressor protein (pVHL) is the signature lesion in the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. Moreover, chromatin regulators are frequently mutated in this disease. We found that ccRCC displays increased H3K27 acetylation and a shift toward mono- or unmethylated H3K27 caused by an HIF-dependent increase in H3K27 demethylase activity...
July 12, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28700774/a-unique-program-to-incorporate-volunteers-into-a-nationwide-emergency-medical-system-maximizing-preparedness-for-a-mass-casualty-incident
#13
Eli Jaffe, Evan Avraham Alpert, Ari M Lipsky
No abstract text is available yet for this article.
July 12, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28698238/protective-factors-for-social-emotional-well-being-of-refugee-children-in-the-first-three-years-of-settlement-in-australia
#14
Karen Zwi, Lisa Woodland, Katrina Williams, Pamela Palasanthiran, Santuri Rungan, Adam Jaffe, Susan Woolfenden
AIM: This longitudinal study investigated protective factors for social-emotional well-being in refugee children in Australia. METHODS: Newly arrived refugee children aged 4-15 years were recruited between 2009 and 2013 and assessments were conducted at two points, at years 2 and 3 postarrival. Social-emotional well-being was assessed using the Strengths and Difficulties Questionnaire (SDQ). Protective factors were assessed by structured interview and the Social Readjustment Rating Scale (SRRS); scores <150 reflect fewer stressful life events in the previous year...
July 11, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28697881/incarceration-of-the-posterior-tibial-tendon-in-an-isolated-comminuted-medial-malleolus-fracture
#15
David Jaffe, Matthew W Christian, Annie Weber, R Frank Henn
Isolated medial malleolar fractures are a less common presentation of an ankle fracture. Treatment is not universally accepted, although many have agreed that any displacement warrants anatomic reduction and fixation. We present a case of an isolated, comminuted medial malleolar fracture that was displaced secondary to entrapment of the posterior tibial tendon between the fracture fragments requiring surgical intervention. The patient was treated with prompt open reduction and internal fixation and had an excellent functional outcome at 1 year...
July 8, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28696753/evolution-of-the-reactor-antineutrino-flux-and-spectrum-at-daya-bay
#16
F P An, A B Balantekin, H R Band, M Bishai, S Blyth, D Cao, G F Cao, J Cao, Y L Chan, J F Chang, Y Chang, H S Chen, Q Y Chen, S M Chen, Y X Chen, Y Chen, J Cheng, Z K Cheng, J J Cherwinka, M C Chu, A Chukanov, J P Cummings, Y Y Ding, M V Diwan, M Dolgareva, J Dove, D A Dwyer, W R Edwards, R Gill, M Gonchar, G H Gong, H Gong, M Grassi, W Q Gu, L Guo, X H Guo, Y H Guo, Z Guo, R W Hackenburg, S Hans, M He, K M Heeger, Y K Heng, A Higuera, Y B Hsiung, B Z Hu, T Hu, E C Huang, H X Huang, X T Huang, Y B Huang, P Huber, W Huo, G Hussain, D E Jaffe, K L Jen, X P Ji, X L Ji, J B Jiao, R A Johnson, D Jones, L Kang, S H Kettell, A Khan, S Kohn, M Kramer, K K Kwan, M W Kwok, T J Langford, K Lau, L Lebanowski, J Lee, J H C Lee, R T Lei, R Leitner, J K C Leung, C Li, D J Li, F Li, G S Li, Q J Li, S Li, S C Li, W D Li, X N Li, X Q Li, Y F Li, Z B Li, H Liang, C J Lin, G L Lin, S Lin, S K Lin, Y-C Lin, J J Ling, J M Link, L Littenberg, B R Littlejohn, J L Liu, J C Liu, C W Loh, C Lu, H Q Lu, J S Lu, K B Luk, X Y Ma, X B Ma, Y Q Ma, Y Malyshkin, D A Martinez Caicedo, K T McDonald, R D McKeown, I Mitchell, Y Nakajima, J Napolitano, D Naumov, E Naumova, H Y Ngai, J P Ochoa-Ricoux, A Olshevskiy, H-R Pan, J Park, S Patton, V Pec, J C Peng, L Pinsky, C S J Pun, F Z Qi, M Qi, X Qian, R M Qiu, N Raper, J Ren, R Rosero, B Roskovec, X C Ruan, H Steiner, P Stoler, J L Sun, W Tang, D Taychenachev, K Treskov, K V Tsang, C E Tull, N Viaux, B Viren, V Vorobel, C H Wang, M Wang, N Y Wang, R G Wang, W Wang, X Wang, Y F Wang, Z Wang, Z Wang, Z M Wang, H Y Wei, L J Wen, K Whisnant, C G White, L Whitehead, T Wise, H L H Wong, S C F Wong, E Worcester, C-H Wu, Q Wu, W J Wu, D M Xia, J K Xia, Z Z Xing, J L Xu, Y Xu, T Xue, C G Yang, H Yang, L Yang, M S Yang, M T Yang, Y Z Yang, M Ye, Z Ye, M Yeh, B L Young, Z Y Yu, S Zeng, L Zhan, C Zhang, C C Zhang, H H Zhang, J W Zhang, Q M Zhang, R Zhang, X T Zhang, Y M Zhang, Y X Zhang, Y M Zhang, Z J Zhang, Z Y Zhang, Z P Zhang, J Zhao, L Zhou, H L Zhuang, J H Zou
The Daya Bay experiment has observed correlations between reactor core fuel evolution and changes in the reactor antineutrino flux and energy spectrum. Four antineutrino detectors in two experimental halls were used to identify 2.2 million inverse beta decays (IBDs) over 1230 days spanning multiple fuel cycles for each of six 2.9 GW_{th} reactor cores at the Daya Bay and Ling Ao nuclear power plants. Using detector data spanning effective ^{239}Pu fission fractions F_{239} from 0.25 to 0.35, Daya Bay measures an average IBD yield σ[over ¯]_{f} of (5...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28696081/peripheral-artery-disease-breakthroughs-in-techniques-and-treatments
#17
Michael R Jaff
No abstract text is available yet for this article.
October 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28680766/cerebrovascular-fibromuscular-dysplasia-the-mgh-cohort-and-literature-review
#18
Andrea M Harriott, Eli Zimmerman, Aneesh B Singhal, Michael R Jaff, Mark E Lindsay, Guy A Rordorf
BACKGROUND: Fibromuscular dysplasia (FMD) is a rare noninflammatory, nonatherosclerotic arteriopathy of medium-sized arteries affecting up to 7% of the population. The disease can affect any artery but commonly affects renal, extracranial carotid, and vertebral arteries. The epidemiology and natural course of cerebrovascular FMD is unknown and requires further investigation. METHODS: We present demographic and outcomes data on a case series of 81 patients with cerebrovascular FMD from Massachusetts General Hospital presenting between 2011 and 2015 followed by a review of the peer-reviewed literature...
June 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28679093/pd-1-blockade-in-mediastinal-gray-zone-lymphoma
#19
LETTER
Christopher Melani, Ajay Major, Jeffrey Schowinsky, Mark Roschewski, Stefania Pittaluga, Elaine S Jaffe, Svetlana D Pack, Zied Abdullaev, Mark A Ahlman, Jennifer J Kwak, Rustain Morgan, Rachel Rabinovitch, Zenggang Pan, Bradley M Haverkos, Jonathan A Gutman, Daniel A Pollyea, Clayton A Smith, Wyndham H Wilson, Manali Kamdar
New England Journal of Medicine, Volume 377, Issue 1, Page 89-91, July 2017.
July 6, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28657323/doubly-resonant-nanoantennas-on-diamond-for-spatial-addressing-of-spin-states
#20
Tzach Jaffe, Ofir Sorias, Lior Gal, Rafi Kalish, Meir Orenstein
The negatively charged nitrogen-vacancy (NV) color center in diamond is an important atom-like system for emergent quantum technologies and sensing at room temperature. The light emission rates and collection efficiency are key issues toward realizing NV-based quantum devices. In that aspect, we propose and experimentally demonstrate a selective and spatially localized method for enhancing the light-matter interaction of shallow NV centers in bulk diamonds. This was achieved by polarized doubly resonant plasmonic antennas, tuned to the NV phonon sideband transition peak in the red and the narrowband near infrared (NIR) singlet transition...
June 28, 2017: Nano Letters
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