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https://www.readbyqxmd.com/read/28516840/victim-alcohol-intoxication-during-a-sexual-assault-relations-with-subsequent-ptsd-symptoms
#1
Anna E Jaffe, Anne L Steel, David DiLillo, Lesa Hoffman, Kim L Gratz, Terri L Messman-Moore
This study examines associations between women's alcohol intoxication at the time of sexual assault and posttraumatic stress disorder (PTSD) symptoms. Drawing on the dual representation theory (Brewin, Gregory, Lipton, & Burgess, 2010), we hypothesized that intoxication at the time of assault would be positively associated with both overall symptoms of PTSD and PTSD reexperiencing symptoms in particular. A total of 143 community women (ages 18-26 years; 71.3% European American) reporting sexual victimization completed questionnaires assessing severity of coercion involved in the assault, perceived level of intoxication at the time of assault, and current PTSD symptoms...
May 17, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28515003/reverse-atrial-electrical-remodeling-induced-by-cardiac-resynchronization-therapy
#2
Bryce Alexander, Fariha Sadiq, Kousha Azimi, Benedict Glover, Pavel Antiperovitch, Wilma M Hopman, Zardasht Jaff, Adrian Baranchuk
PURPOSE: Cardiac resynchronization therapy (CRT) has been shown to improve left atrial function; however the effect on reverse electrical remodeling has been poorly evaluated. We hypothesized that CRT might induce reverse atrial electrical remodeling manifesting in the surface ECG as a shortening in P-wave duration. METHODS: Patients with CRT and more than 92% biventricular pacing at minimum follow-up of 1 year were included in the analysis. Those with prior history of atrial fibrillation (AF) were excluded...
April 28, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28505772/fame-and-obsolescence-disentangling-growth-and-aging-dynamics-of-patent-citations
#3
K W Higham, M Governale, A B Jaffe, U Zülicke
We present an analysis of citations accrued over time by patents granted by the United States Patent and Trademark Office in 1998. In contrast to previous studies, a disaggregation by technology category is performed, and exogenously caused citation-number growth is controlled for. Our approach reveals an intrinsic citation rate that clearly separates into an-in the long run, exponentially time-dependent-aging function and a completely time-independent preferential-attachment-type growth kernel. For the general case of such a separable citation rate, we obtain the time-dependent citation distribution analytically in a form that is valid for any functional form of its aging and growth parts...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28505623/effect-of-a-low-rank-denoising-algorithm-on-quantitative-magnetic-resonance-imaging-based-measures-of-liver-fat-and-iron
#4
Brian C Allen, Felix Lugauer, Dominik Nickel, Lubna Bhatti, Randa A Dafalla, Brian M Dale, Tracy A Jaffe, Mustafa R Bashir
PURPOSE: This study aimed to assess the effect of a low-rank denoising algorithm on quantitative magnetic resonance imaging-based measures of liver fat and iron. MATERIALS AND METHODS: This was an institutional review board-approved, Health Insurance Portability and Accountability Act-compliant, retrospective analysis of 42 consecutive subjects who were imaged at 3T using a multiecho gradient echo sequence that was reconstructed using the multistep adaptive fitting algorithm to obtain quantitative proton density fat fraction (PDFF) and R2* maps (original maps)...
May 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28504642/ion-recombination-correction-factor-in-scanned-light-ion-beams-for-absolute-dose-measurement-using-plane-parallel-ionisation-chambers
#5
Severine Rossomme, Julian Horn, Stephan Brons, Oliver Jaekel, Andrea Mairani, Mario Ciocca, Vincent Floquet, Francesco Romano, Diana Rodriguez Garcia, Stefaan Vynckier, Hugo Palmans
Based on international reference dosimetry protocols for light-ion beams, a correction factor (<i>k<sub>s</sub></i>) has to be applied to the response of a plane-parallel ionisation chamber, to account for recombination of negative and positive charges in its air cavity before these charges can be collected on the electrodes. In this work, <i>k<sub>s</sub></i> for IBA PPC40 Roos-type chambers is investigated in four scanned light-ion beams (proton, helium, carbon and oxygen)...
May 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28489477/combined-sciatic-and-lumbar-plexus-nerve-blocks-for-the-analgesic-management-of-hip-arthroscopy-procedures-a-retrospective-review
#6
J Douglas Jaffe, Theodore Ross Morgan, Gregory B Russell
Hip arthroscopy is a minimally invasive alternative to open hip surgery. Despite its minimally invasive nature, there can still be significant reported pain following these procedures. The impact of combined sciatic and lumbar plexus nerve blocks on postoperative pain scores and opioid consumption in patients undergoing hip arthroscopy was investigated. A retrospective analysis of 176 patients revealed that compared with patients with no preoperative peripheral nerve block, significant reductions in pain scores to 24 hours were reported and decreased opioid consumption during the post anesthesia care unit (PACU) stay was recorded; no significant differences in opioid consumption out to 24 hours were discovered...
May 10, 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28489285/scai-appropriate-use-criteria-for-peripheral-arterial-interventions-an-update
#7
Andrew J Klein, Michael R Jaff, Bruce H Gray, Herbert D Aronow, Robert M Bersin, Larry J Diaz-Sandoval, Robert S Dieter, Douglas Drachman, Dmitriy N Feldman, Osvaldo S Gigliotti, Kamal Gupta, Sahil A Parikh, Duane S Pinto, Mehdi H Shishehbor, Christopher J White
No abstract text is available yet for this article.
May 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28485729/altered-expression-of-histamine-signaling-genes-in-autism-spectrum-disorder
#8
C Wright, J H Shin, A Rajpurohit, A Deep-Soboslay, L Collado-Torres, N J Brandon, T M Hyde, J E Kleinman, A E Jaffe, A J Cross, D R Weinberger
The histaminergic system (HS) has a critical role in cognition, sleep and other behaviors. Although not well studied in autism spectrum disorder (ASD), the HS is implicated in many neurological disorders, some of which share comorbidity with ASD, including Tourette syndrome (TS). Preliminary studies suggest that antagonism of histamine receptors 1-3 reduces symptoms and specific behaviors in ASD patients and relevant animal models. In addition, the HS mediates neuroinflammation, which may be heightened in ASD...
May 9, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28485405/investigating-the-neuroimmunogenic-architecture-of-schizophrenia
#9
R Birnbaum, A E Jaffe, Q Chen, J H Shin, J E Kleinman, T M Hyde, D R Weinberger
The role of the immune system in schizophrenia remains controversial despite numerous studies to date. Most studies have profiled expression of select genes or proteins in peripheral blood, but none have focused on the expression of canonical pathways that mediate overall immune response. The current study used a systematic genetic approach to investigate the role of the immune system in a large sample of post-mortem brain of patients with schizophrenia: RNA sequencing was performed to assess the differential expression of 561 immune genes and 20 immune pathways in dorsolateral prefrontal cortex (DLPFC) (144 schizophrenia and 196 control subjects) and hippocampus (83 schizophrenia and 187 control subjects)...
May 9, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28485403/gad1-alternative-transcripts-and-dna-methylation-in-human-prefrontal-cortex-and-hippocampus-in-brain-development-schizophrenia
#10
R Tao, K N Davis, C Li, J H Shin, Y Gao, A E Jaffe, M C Gondré-Lewis, D R Weinberger, J E Kleinman, T M Hyde
Genetic variations and adverse environmental events in utero or shortly after birth can lead to abnormal brain development and increased risk of schizophrenia. γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian brain, plays a vital role in normal brain development. GABA synthesis is controlled by enzymes derived from two glutamic acid decarboxylase (GAD) genes, GAD1 and GAD2, both of which produce transcript isoforms. While the full-length GAD1 transcript (GAD67) has been implicated in the neuropathology of schizophrenia, the transcript structure of GAD1 in the human brain has not been fully characterized...
May 9, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28485182/a-quantitative-angiographic-comparison-of-restenotic-tissue-following-placement-of-drug-eluting-stents-and-bare-metal-stents-in-symptomatic-patients-with-femoropopliteal-disease
#11
Gary M Ansel, Michael R Jaff, Jeffrey J Popma, Anthony J Battisti, Aaron E Lottes, Paul Harnish, Michael D Dake
PURPOSE: To evaluate the patterns of in-stent restenosis (ISR) within femoropopliteal bare metal stents (BMS) and drug-eluting stents (DES) as determined by quantitative angiographic analysis. METHODS: Utilizing results from independent core laboratory angiographic imaging analysis, quantitative assessment of the restenotic tissue burden was evaluated in 33 patients with symptomatic femoropopliteal ISR, including 20 lesions in 19 patients (mean age 71.5±8.1 years; 11 men) treated with DES and 14 lesions in 14 patients (mean age 70...
May 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28485179/what-to-do-when-you-question-cardiac-troponin-values
#12
Johannes Mair, Bertil Lindahl, Christian Müller, Evangelos Giannitsis, Kurt Huber, Martin Möckel, Mario Plebani, Kristian Thygesen, Allan S Jaffe
High-sensitivity cardiac troponin assays enable cardiac troponin measurement with a high degree of analytical sensitivity and a low level of analytical imprecision at the low measuring range. One of the most important advantages of these new assays is that they allow novel, more rapid approaches for ruling in or ruling out acute myocardial infarctions. The increase in the early diagnostic sensitivity of high-sensitivity cardiac troponin assays comes at the cost of a reduced acute myocardial infarction specificity of the biomarker, because more patients with other causes of acute or chronic myocardial injury without overt myocardial ischaemia are detected than with previous cardiac troponin assays...
May 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28481942/adult-arabs-have-higher-risk-for-diabetes-mellitus-than-jews-in-israel
#13
Anat Jaffe, Shmuel Giveon, Liat Wulffhart, Bernice Oberman, Maslama Baidousi, Arnona Ziv, Ofra Kalter-Leibovici
OBJECTIVE: Diabetes mellitus is an emerging epidemic in the Arab world. Although high diabetes prevalence is documented in Israeli Arabs, information from cohort studies is scant. METHODS: This is a population study, based on information derived between 2007-2011, from the electronic database of the largest health fund in Israel, among Arabs and Jews. Prevalence, 4-year-incidence and diabetes hazard ratios [HRs], adjusted for sex and the metabolic-syndrome [MetS]-components, were determined in 3 age groups (<50 years, 50-59 years, and ≥60 years)...
2017: PloS One
https://www.readbyqxmd.com/read/28479207/measures-that-identify-prescription-medication-misuse-abuse-and-related-events-in-clinical-trials-acttion-critique-and-recommended-considerations
#14
Shannon M Smith, Judith K Jones, Nathaniel P Katz, Carl L Roland, Beatrice Setnik, Jeremiah J Trudeau, Stephen Wright, Laurie B Burke, Sandra D Comer, Richard C Dart, Raymond Dionne, J David Haddox, Jerome H Jaffe, Ernest A Kopecky, Bridget A Martell, Ivan D Montoya, Marsha Stanton, Ajay D Wasan, Dennis C Turk, Robert H Dworkin
Accurate assessment of inappropriate medication use events (i.e., misuse, abuse, and related events [MAREs]) occurring in clinical trials is an important component in evaluating a medication's abuse potential. A meeting was convened to review all instruments measuring such events in clinical trials according to previously published standardized terminology and definitions [27]. Only 2 approaches have been reported that are specifically designed to identify and classify MAREs occurring in clinical trials, rather than to measure an individual's risk of using a medication inappropriately: the Self-Reported Misuse, Abuse, and Diversion [SR-MAD] instrument and the Misuse, Abuse, and Diversion Drug Event Reporting System [MADDERS]...
May 4, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28473130/carotid-artery-stenting-versus-endarterectomy-for-stroke-prevention-a-meta-analysis-of-clinical-trials
#15
Partha Sardar, Saurav Chatterjee, Herbert D Aronow, Amartya Kundu, Preethi Ramchand, Debabrata Mukherjee, Ramez Nairooz, William A Gray, Christopher J White, Michael R Jaff, Kenneth Rosenfield, Jay Giri
BACKGROUND: Data conflict regarding the relative effectiveness of carotid artery stenting (CAS) and carotid artery endarterectomy (CEA) for the prevention of stroke due to carotid artery stenosis. OBJECTIVES: The authors performed an updated meta-analysis evaluating the efficacy and safety of CAS versus CEA, given recently published clinical trial data. METHODS: Databases were searched through April 30, 2016. Randomized trials with ≥50 patients, that had exclusive use of embolic-protection devices, and that compared CAS against CEA for the treatment of carotid artery stenosis were selected...
May 9, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28471566/should-we-absorb-the-concept-of-three-dimensional-quantitative-coronary-angiography-in-the-catheterization-laboratory
#16
EDITORIAL
Ronen Rubinshtein, Ronen Jaffe
No abstract text is available yet for this article.
July 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28471091/superb-final-3-year-outcomes-using-interwoven-nitinol-biomimetic-supera-stent
#17
Lawrence A Garcia, Kenneth R Rosenfield, Christopher D Metzger, Frank Zidar, Ashish Pershad, Jeffrey J Popma, Margo Zaugg, Michael R Jaff
IMPORTANCE: Long-term outcomes of an interwoven nitinol stent design represent the best in class for treatment of lower limb arterial obstructive disease METHODS: The subjects were enrolled in an open single arm study comparing the outcomes to an FDA mandated objective performance goal (OPG). RESULTS: About 325 patients (264 intention-to-treat and 64 roll-in subjects) were enrolled. Mean follow-up period was 887+/- 352 days. Treated lesion lengths were 7.8 cm ± 4...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28470609/generation-of-recombinant-n-linked-glycoproteins-in-e-coli
#18
Benjamin Strutton, Stephen R P Jaffé, Jagroop Pandhal, Phillip C Wright
The production of N-linked recombinant glycoproteins is possible in a variety of biotechnology host cells, and more recently in the bacterial workhorse, Escherichia coli. This methods chapter will outline the components and procedures needed to produce N-linked glycoproteins in E. coli, utilizing Campylobacter jejuni glycosylation machinery, although other related genes can be used with minimal tweaks to this methodology. To ensure a successful outcome, various methods will be highlighted that can confirm glycoprotein production to a high degree of confidence, including the gold standard of mass spectrometry analysis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28464826/microtaboo-a-general-and-practical-solution-to-the-k-disjoint-problem
#19
Mohammed Al-Jaff, Eric Sandström, Manfred Grabherr
BACKGROUND: A common challenge in bioinformatics is to identify short sub-sequences that are unique in a set of genomes or reference sequences, which can efficiently be achieved by k-mer (k consecutive nucleotides) counting. However, there are several areas that would benefit from a more stringent definition of "unique", requiring that these sub-sequences of length W differ by more than k mismatches (i.e. a Hamming distance greater than k) from any other sub-sequence, which we term the k-disjoint problem...
May 2, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28461016/comparison-of-visual-outcomes-in-coats-disease-a-20-year-experience
#20
Sally S Ong, Edward G Buckley, Brooks W McCuen, Glenn J Jaffe, Eric A Postel, Tamer H Mahmoud, Sandra S Stinnett, Cynthia A Toth, Lejla Vajzovic, Prithvi Mruthyunjaya
PURPOSE: To report differences in visual acuities among patients with Coats' disease who sought treatment at a tertiary care university-based practice. DESIGN: Single-center retrospective cohort study. PARTICIPANTS: Patients with Coats' disease diagnosed clinically, angiographically, or both from 1995 through 2015. METHODS: Patients were divided into 2 groups based on date of presentation: decade 1 (1995-2005) and decade 2 (2006-2015)...
April 28, 2017: Ophthalmology
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