Natalie C W Ho, Richard Ai Bethlehem, Jakob Seidlitz, Nikita Nogovitsyn, Paul Metzak, Pedro L Ballester, Stefanie Hassel, Susan Rotzinger, Jordan Poppenk, Raymond W Lam, Valerie H Taylor, Roumen Milev, Edward T Bullmore, Aaron F Alexander-Bloch, Benicio N Frey, Kate L Harkness, Jean Addington, Sidney H Kennedy, Katharine Dunlop
BACKGROUND: Patients with major depressive disorder (MDD) can present with altered brain structure and deficits in cognitive function similar to aging. Yet, the interaction between age-related brain changes and brain development in MDD remains understudied. In a cohort of adolescents and adults with and without MDD, we assessed brain aging differences and associations through a newly developed tool quantifying normative neurodevelopmental trajectories. METHODS: 304 MDD participants and 236 non-depressed controls were recruited and scanned from three studies under the Canadian Biomarker Integration Network for Depression...
April 26, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging