R Zibigu, A Abidan, D Adilai, Y Li, X Kang, Q Yu, B Deng, X Zheng, M Wang, J Li, H Wang, C Zhang
OBJECTIVE: To investigate the effect of LAG-3 deficiency (LAG3-/- ) on natural killer (NK) cell function and hepatic fibrosis in mice infected with Echinococcus multilocularis . METHODS: C57BL/6 mice, each weighing (20 ± 2) g, were divided into the LAG3-/- and wild type (WT) groups, and each mouse in both groups was inoculated with 3 000 E. multilocularis protoscoleces via the hepatic portal vein. Mouse liver and spleen specimens were collected 12 weeks post-infection, sectioned and stained with sirius red, and the hepatic lesions and fibrosis were observed...
April 7, 2024: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control