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https://www.readbyqxmd.com/read/29666665/splenic-abscess-an-uncommon-entity-with-potentially-life-threatening-evolution
#1
Mei-Chun Lee, Chun-Ming Lee
Background/Purpose: Splenic abscess is rare with potentially life-threatening evolution. The aim of this study is to review the clinical features, microbiological etiologies, treatment, and outcomes of patients with splenic abscess. Methods: We reviewed the admitted patients with suspected splenic abscess and made the diagnosis of splenic abscess. The clinical characteristics, underlying diseases, treatment course, organism spectra, abscess number and size, therapeutic methods, and clinical outcome at a tertiary medical center in Taiwan over a period of 5 years were analyzed...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29666112/increased-erythrophagocytosis-induces-ferroptosis-in-red-pulp-macrophages-in-a-mouse-model-of-transfusion
#2
Lyla A Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P Weisberg, Brent R Stockwell, Eldad A Hod, Steven L Spitalnik
Macrophages play important roles in recycling iron derived from the clearance of red blood cells (RBCs). They are also a critically important component of host defense, protecting against invading pathogens. However, the effects on macrophage biology of acutely ingesting large numbers of RBCs are not completely understood. To investigate this issue, we used a mouse model of RBC transfusion and clearance, which mimics the clinical setting. In this model, transfusions of refrigerator storage-damaged (i.e., "old") RBCs led to increased erythrophagocytosis by splenic red pulp macrophages (RPMs)...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29664837/chronic-alcohol-ingestion-worsens-survival-and-alters-gut-epithelial-apoptosis-and-cd8-t-cell-function-after-pseudomonas-aeruginosa-pneumonia-induced-sepsis
#3
Nathan J Klingensmith, Katherine T Fay, John D Lyons, Ching-Wen Chen, Shunsuke Otani, Zhe Liang, Deena B Chihade, Eileen M Burd, Mandy L Ford, Craig M Coopersmith
Mortality is higher in septic patients with a history of alcohol use disorder than in septic patients without a history of chronic alcohol usage. We have previously described a model of chronic alcohol ingestion followed by sepsis from cecal ligation and puncture in which alcohol-fed septic mice have higher mortality than water-fed septic mice, associated with altered gut integrity and increased production of TNF and IFNγ by splenic CD4 T cells without alterations in CD8 T cell function. The purpose of this study was to determine whether this represents a common host response to the combination of alcohol and sepsis by creating a new model in which mice with chronic alcohol ingestion were subjected to a different model of sepsis...
April 16, 2018: Shock
https://www.readbyqxmd.com/read/29664715/late-infection-related-mortality-in-asplenic-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#4
Brent R Weil, Arin L Madenci, Qi Liu, Rebecca M Howell, Todd M Gibson, Yutaka Yasui, Joseph P Neglia, Wendy M Leisenring, Susan A Smith, Emily S Tonorezos, Danielle N Friedman, Louis S Constine, Christopher L Tinkle, Lisa R Diller, Gregory T Armstrong, Kevin C Oeffinger, Christopher B Weldon
Purpose Infection-related outcomes associated with asplenia or impaired splenic function in survivors of childhood cancer remains understudied. Methods Late infection-related mortality was evaluated in 20,026 5-year survivors of childhood cancer (diagnosed < 21 years of age from 1970 to 1999; median age at diagnosis, 7.0 years [range, 0 to 20 years]; median follow-up, 26 years [range, 5 to 44 years]) using cumulative incidence and piecewise-exponential regression models to estimate adjusted relative rates (RRs)...
April 17, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29662866/a-rare-case-of-splenic-diffuse-red-pulp-small-b-cell-lymphoma-sdrpl-a-review-of-the-literature-on-primary-splenic-lymphoma-with-hairy-cells
#5
Tanush Vig, Thomas Alex Kodiatte, Marie Therese Manipadam, Fouzia Nambiathayil Aboobacker
No abstract text is available yet for this article.
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662860/splenic-myeloid-metaplasia-in-warm-autoimmune-hemolytic-anemia-waiha-a-retrospective-study
#6
Víctor Manuel Anguiano-Álvarez, Alonso Hernández-Company, Nashla Hamdan-Pérez, Daniel Montante-M, Diego A Zúñiga-Tamayo, Sergio Rodríguez-Rodríguez, Alan Pomerantz, Elena J Tuna-Aguilar
Background: Splenic myeloid metaplasia (SMM) is a kind of extramedullary hematopoiesis, whereas its clinical significance in wAIHA remains unclear. The aim of this study is evaluating the frequency and clinical characteristics of SMM, compared with splenic-congestion (SC). Methods: We included patients with wAIHA treated in a Mexican tertiary hospital between January 1992 and December 2015. All patients received steroids as first-line treatment and splenectomy as second-line treatment...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662328/hyporeninemic-hypoaldosteronism-in-a-patient-with-diabetes-mellitus-an-unforgettable-case-report
#7
Naziha Chelaghma, Samson O Oyibo
A 58-year-old man presented with a 3-year history of chronic and intermittent hyperkalemia requiring recurrent attendances to the emergency department for urgent treatment. His medical history included secondary diabetes mellitus following a bout of acute pancreatitis and a previous splenectomy for a spontaneous splenic rupture. He also had a history of prolonged use of non-steroidal anti-inflammatory drugs for back pain and painful neuropathy. He was not on any medication or diet that would cause a raised serum potassium level and his renal function was normal...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29662129/intracellular-replication-of-streptococcus-pneumoniae-inside-splenic-macrophages-serves-as-a-reservoir-for-septicaemia
#8
Giuseppe Ercoli, Vitor E Fernandes, Wen Y Chung, Joseph J Wanford, Sarah Thomson, Christopher D Bayliss, Kornelis Straatman, Paul R Crocker, Ashley Dennison, Luisa Martinez-Pomares, Peter W Andrew, E Richard Moxon, Marco R Oggioni
Bacterial septicaemia is a major cause of mortality, but its pathogenesis remains poorly understood. In experimental pneumococcal murine intravenous infection, an initial reduction of bacteria in the blood is followed hours later by a fatal septicaemia. These events represent a population bottleneck driven by efficient clearance of pneumococci by splenic macrophages and neutrophils, but as we show in this study, accompanied by occasional intracellular replication of bacteria that are taken up by a subset of CD169+ splenic macrophages...
April 16, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29661827/oral-nahco-3-activates-a-splenic-anti-inflammatory-pathway-evidence-that-cholinergic-signals-are-transmitted-via-mesothelial-cells
#9
Sarah C Ray, Babak Baban, Matthew A Tucker, Alec J Seaton, Kyu Chul Chang, Elinor C Mannon, Jingping Sun, Bansari Patel, Katie Wilson, Jacqueline B Musall, Hiram Ocasio, Debra Irsik, Jessica A Filosa, Jennifer C Sullivan, Brendan Marshall, Ryan A Harris, Paul M O'Connor
We tested the hypothesis that oral NaHCO3 intake stimulates splenic anti-inflammatory pathways. Following oral NaHCO3 loading, macrophage polarization was shifted from predominantly M1 (inflammatory) to M2 (regulatory) phenotypes, and FOXP3+ CD4+ T-lymphocytes increased in the spleen, blood, and kidneys of rats. Similar anti-inflammatory changes in macrophage polarization were observed in the blood of human subjects following NaHCO3 ingestion. Surprisingly, we found that gentle manipulation to visualize the spleen at midline during surgical laparotomy (sham splenectomy) was sufficient to abolish the response in rats and resulted in hypertrophy/hyperplasia of the capsular mesothelial cells...
April 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29661716/small-cell-lymphocytic-variant-of-marginal-zone-lymphoma-a-distinct-form-of-marginal-zone-lymphoma-derived-from-na%C3%A3-ve-b-cells-as-a-cutaneous-counterpart-to-the-na%C3%A3-ve-marginal-zone-lymphoma-of-splenic-origin
#10
REVIEW
Cynthia M Magro, Luke C Olson
Primary cutaneous marginal zone lymphoma most commonly represents an indolent form of cutaneous B cell lymphoma. However, epidermotropic marginal zone lymphoma, blastic marginal zone lymphoma and B cell dominant variants without isotype switching can be associated with extracutaneous dissemination. The presumptive cell of origin is a post germinal center B cell with plasmacytic features. In the extracutaneous setting, however, a naïve B cell origin has been proposed for a subset of marginal zone lymphomas, notably splenic marginal zone lymphoma...
February 21, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661276/postoperative-morbidity-and-mortality-for-malignant-colon-obstruction-the-american-college-of-surgeon-calculator-reliability
#11
Maxime K Collard, David Moszkowicz, Anne-Caroline Clause-Verdreau, Alain Beauchet, Tristan Cudennec, Karina Vychnevskaia, Robert Malafosse, Frédérique Peschaud
BACKGROUND: The American College of surgical risk calculator (SRC) score has never been validated specifically for surgery in emergency. The objective was to evaluate the reliability of this calculator in patients with malignant colon obstruction. MATERIALS AND METHODS: We retrospectively have analyzed the morbidity and mortality observed in operated patients. Risk factors for postoperative morbidity and mortality were analyzed by logistic regression model. We have compared the morbidity and mortality estimated by the SRC score with that observed using the Brier Score (BS)...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29660280/comparison-of-linear-and-hyperbranched-polyether-lipids-for-liposome-shielding-by-18f-radiolabeling-and-positron-emission-tomography
#12
Karolin Wagener, Matthias Worm, Stefanie Pektor, Meike Schinnerer, Raphael Thiermann, Matthias Miederer, Holger Frey, Frank Rösch
Multifunctional and highly biocompatible polyether structures play a key role in shielding liposomes from degradation in the bloodstream, providing also multiple functional groups for further attachment of targeting moieties. In this work hyperbranched polyglycerol (hbPG) bearing lipids with long alkyl chain anchor are evaluated with respect to steric stabilization of liposomes. The branched polyether lipids possess a hydrophobic bis(hexadecyl)glycerol membrane anchor for the liposomal membrane. hbPG was chosen as a multifunctional alternative to PEG, enabling the eventual linkage of multiple targeting vectors...
April 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29658679/iatrogenic-spleen-injury-during-minimally-invasive-left-colonic-flexure-mobilization-the-quest-for-evidence-based-results
#13
Alberto Mangano, Federico Gheza, Pier C Giulianotti
INTRODUCTION: To assess the frequency, risk factors and outcomes of iatrogenic spleen injury during minimally invasive colo-rectal surgery with a particular focus on the routine splenic flexure mobilization tehcnique. EVIDENCE ACQUISITION: Exclusion criteria: 1. topic not pertinent to the main topic of the review; 2. All case reports, editorials, conference highlights were excluded. After a title and abstract first selection and a final full-text analysis has been performed...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29657728/can-we-predict-delayed-undesirable-events-after-blunt-injury-to-the-torso-visceral-organs
#14
Kenichiro Uchida, Yasumitsu Mizobata, Naohiro Hagawa, Tomonori Yamamoto, Shinichiro Kaga, Tomohiro Noda, Naoki Shinyama, Tetsuro Nishimura, Hiromasa Yamamoto
Aim: Blunt injuries to visceral organs have the potential to lead to delayed pseudoaneurysm formation or organ rupture, but current trauma and surgical guidelines do not recommend repetitive imaging. This study examined the incidence and timing of delayed undesirable events and established advisable timing for follow-up imaging and appropriate observational admission. Methods: Patients with blunt splenic (S), liver (L), or kidney (K) injury treated with non-operative management (NOM) in our institution were included and retrospectively reviewed...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29657712/recent-advances-in-understanding-the-biology-of-marginal-zone-lymphoma
#15
REVIEW
Francesco Bertoni, Davide Rossi, Emanuele Zucca
There are three different marginal zone lymphomas (MZLs): the extranodal MZL of mucosa-associated lymphoid tissue (MALT) type (MALT lymphoma), the splenic MZL, and the nodal MZL. The three MZLs share common lesions and deregulated pathways but also present specific alterations that can be used for their differential diagnosis. Although trisomies of chromosomes 3 and 18, deletions at 6q23, deregulation of nuclear factor kappa B, and chromatin remodeling genes are frequent events in all of them, the three MZLs differ in the presence of recurrent translocations, mutations affecting the NOTCH pathway, and the transcription factor Kruppel like factor 2 ( KLF2) or the receptor-type protein tyrosine phosphatase delta ( PTPRD )...
2018: F1000Research
https://www.readbyqxmd.com/read/29657256/colonal-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-with-novel-phenotype-of-cytoplasmic-cd3-expression
#16
Yumi Aoyama, Hiroko Tsunemine, Yuriko Zushi, Hayato Maruoka, Yuta Goto, Taiichi Kodaka, Tomoo Itoh, Takayuki Takahashi
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a new clinical entity that was reclassified from enteropathy-associated T-cell lymphoma in the 2016 WHO classification. An 83-year-old man with fever and diarrhea was referred to our hospital because of free air in the abdominal cavity and wall thickening of the large intestine on CT. Colonofiberscopic examination revealed mucosal edema and multiple ulcers at the sigmoid colon, splenic flexure, and transverse colon. Histopathological examination of the mucosal biopsy specimen demonstrated dense infiltration of small lymphocytes with nuclear atypia, some of which exhibited intraepithelial invasion...
April 13, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29656712/isolated-splenic-lymphangioma-presenting-as-a-huge-mass-causing-anemia-and-abdominal-distension-in-an-adult-patient-a-case-report
#17
Boubacar Efared, Gabrielle Atsame-Ebang, Aliou Zabeirou, Nawal Hammas, Khalid Mazaz, Hinde El Fatemi, Laila Chbani
BACKGROUND: Lymphangiomas are uncommon benign lesions of lymphatic vessels very rarely affecting the spleen. Isolated involvement of the spleen in adult patients is rarely reported. CASE PRESENTATION: We report a case of a 40-year-old Arabic woman who presented with a 25-cm abdominal mass, fatigue, and anemia evolving for 6 months. Her physical examination revealed anemic syndrome and an enormous splenomegaly extending beyond the umbilical area. An abdominal computed tomographic scan showed a 25-cm splenic mass with multiple hypodense nodules without enhancement after contrast injection...
April 16, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29656597/splenic-artery-as-a-simple-landmark-indicating-difficulty-during-laparoscopic-distal-pancreatectomy
#18
Yoshiya Ishikawa, Daisuke Ban, Shuichi Watanabe, Keiichi Akahoshi, Hiroaki Ono, Yusuke Mitsunori, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe
INTRODUCTION: The use of laparoscopic distal pancreatectomy (LDP) is increasing worldwide. It is important for surgeons to predict preoperatively the difficulty and risks of a surgery. However, very few reports have evaluated the impact of patient or tumor factors on the difficulty of LDP. We aimed to determine the predictors of technical difficulties when performing LDP. METHODS: This study included 34 patients who underwent LDP. Patient information was obtained retrospectively and included age, gender, BMI, primary disease, previous abdominal surgery, previous pancreatitis, tumor size, tumor proximity to the splenic arterial origin, type of splenic artery (SpA), operative time, blood loss, postoperative pancreatic fistula, and length of hospital stay...
April 15, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29652553/mahonia-oiwakensis-extract-and-its-bioactive-compounds-exert-anti-inflammatory-activities-and-vegf-production-through-m2-macrophagic-polarization-and-stat6-activation
#19
Yea-Chen Liu, Yu-Ying Hsiao, Kuo-Lung Ku, Hui-Fen Liao, Wei-Chun Chao
Macrophages play an indispensable role in the host immune defense. Macrophages can undergo polarization into classically (M1) and alternatively (M2) activated macrophages. M1 macrophages activate immune and inflammatory response, while M2 macrophages are involved in tissue remodeling. Mahonia oiwakensis (Mo) is a herbal medicine in Asia used for its anti-inflammatory and analgesic properties; however, the mechanism is unclear. This study analyzed the effect of Mo extracts and its effects on the polarization of both macrophage RAW264...
April 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29651739/prognostic-utility-of-splenic-response-ratio-in-dipyridamole-pet-myocardial-perfusion-imaging
#20
Karan Bami, Shrankhala Tewari, Fadi Guirguis, Linda Garrard, Ann Guo, Alomgir Hossain, Terrence D Ruddy, Rob S B Beanlands, Robert A deKemp, Benjamin J W Chow, Girish Dwivedi
BACKGROUND: Cardiac magnetic resonance perfusion studies with adenosine stress have shown that splenic response can identify patients with inadequate pharmacologic stress. We investigate the incremental prognostic impact of splenic response ratio (SRR) in patients with normal Rubidium (Rb)-82 PET myocardial perfusion imaging (MPI). METHODS: Consecutive patients undergoing dipyridamole Rb-82 PET MPI for the evaluation of coronary artery disease were screened. Spleen and liver Rb-82 activity was measured and the SRR was calculated: SRR = (Spleen stress/Liver stress)/(Spleen rest/Liver rest)...
April 12, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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