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https://www.readbyqxmd.com/read/29456579/splenic-cyst-as-a-rare-cause-of-fetal-abdominal-cystic-mass-a-multicenter-series-of-nine-cases-and-review-of-the-literature
#1
Waldo Sepulveda, Jose H Ochoa, Daniel Cafici, Amy E Wong, Federico Badano, Elena Andreeva, Elena Y Andreeva
Introduction: Congenital splenic cysts are a rare cause of abdominal cystic masses in the fetus. We describe nine cases of this condition, the largest reported experience to date. A review of the literature for similar cases was also performed. Methods: Cases of congenital splenic cyst were collected from three prenatal diagnostic centers and from a dedicated website of prenatal diagnosis. Information regarding clinical and sonographic findings was obtained by reviewing ultrasound reports and medical records...
February 2018: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29456247/b-cells-are-the-predominant-mediators-of-early-systemic-viral-dissemination-during-rectal-lcmv-infection
#2
Martin Trapecar, Shahzada Khan, Benjamin L Cohn, Frank Wu, Shomyseh Sanjabi
Determining the magnitude of local immune response during mucosal exposure to viral pathogens is critical to understanding the mechanism of viral pathogenesis. We previously showed that vaginal inoculation of lymphocytic choriomeningitis virus (LCMV) fails to induce a robust innate immune response in the lower female reproductive tract (FRT), allowing high titer viral replication and a delay in T-cell-mediated viral control. Despite this immunological delay, LCMV replication remained confined mainly to the FRT and the draining iliac lymph node...
February 19, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29455290/laparoscopic-hemi-splenectomy
#3
Matteo De Pastena, Maarten W Nijkamp, Thomas G van Gulik, Olivier R Busch, H S Hermanides, Marc G Besselink
Laparoscopic splenectomy is now established as a safe and feasible procedure. However, it remains associated with some short- and long-term postoperative complications, especially infectious complications. To our knowledge, this is the first report (with video) focusing on the safety and feasibility of laparoscopic hemi-splenectomy and its surgical outcomes for the treatment of splenic abscesses causing septic emboli. This technique combines the immunological benefits of partial splenectomy and the postoperative benefits of a minimally invasive approach...
February 17, 2018: Surgery Today
https://www.readbyqxmd.com/read/29455235/enlarged-spleen-is-associated-with-low-neutrophil-and-platelet-engraftment-rates-and-poor-survival-after-allogeneic-stem-cell-transplantation-in-patients-with-acute-myeloid-leukemia-and-myelodysplastic-syndrome
#4
Yoshimitsu Shimomura, Masahiko Hara, Daisuke Katoh, Hisako Hashimoto, Takayuki Ishikawa
Primary graft failure can be a cause of early morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT), as it leads to a high risk of severe infections and bleeding. Splenomegaly is associated with primary graft failure in patients of myelofibrosis, but the association between splenomegaly and outcomes after HSCT in patients with myeloid malignancies has not been previously evaluated. The aim of this study was to investigate the effect of spleen volume on engraftment kinetics in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)...
February 17, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29455011/hybrid-retrograde-celiac-artery-stenting-for-acute-mesenteric-ischemia-after-gastric-surgery
#5
Duarte Rego, Paulo Almeida, Paulo Soares, Rui Almeida
INTRODUCTION: Celiac artery (CA) occlusions/stenosis are infrequently associated with liver ischemia due to its unique vascularization where portal vein provides about 75% of liver's perfusion. Collateral flow from gastroduodenal artery also provides, in most cases, enough blood supply to prevent ischemic hepatitis. In cases where these collateral pathways are compromised severe liver ischemia can occur. METHODS: We present a case of acute mesenteric ischemia following gastric surgery that was treated with a hybrid retrograde CA stenting...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29454161/physiological-low-dose-oestrogen-promotes-the-development-of-experimental-autoimmune-thyroiditis-through-the-up-regulation-of-th1-th17-responses
#6
Yang Xiang, Qian Jin, Li Li, Yali Yang, Hongmei Zhang, Miao Liu, Chenling Fan, Jing Li, Zhongyan Shan, Weiping Teng
Previous studies have reported a preponderance of autoimmune thyroiditis (AIT) in females, but the detailed mechanisms have not been elucidated. In this study, we explored the effects of oestrogen on experimental AIT (EAT) and its potential mechanisms in an ovariectomised mouse model through the supplementation of high (equivalent to the level during pregnancy) or low (equivalent to the level at the oestrus stage) doses of oestradiol (E2). We found that EAT incidence, the intrathyroidal inflammatory score, serum anti-thyroglobulin IgG2b levels, splenic mRNA expression of Th1- and Th17-specific transcription factors and typical cytokines and the proportion of IL-12-producing dendritic cells were significantly increased in EAT mice treated with low-dose E2 compared with those in the control group...
February 7, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29452668/should-rituximab-replace-splenectomy-in-the-management-of-splenic-marginal-zone-lymphoma
#7
REVIEW
Christina Kalpadakis, Gerassimos A Pangalis, Maria K Angelopoulou, Sotirios Sachanas, Theodoros P Vassilakopoulos
SMZL is a relatively rare low grade B-cell lymphoma, characterized usually by an indolent clinical behavior. Since there is no prospective randomized trials to establish the best treatment approach, decision on therapeutic management should be based on the available retrospective series. Based on these data, rituximab and splenectomy appear to be the most effective. Splenectomy represented the standard treatment modality until early 2000s. More than 90% of the patients present quick amelioration of splenomegaly related symptoms along with improvement of cytopenias related to hypersplenism...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29451641/splenic-implant-preservation-after-conservation-in-lactated-ringer%C3%A2-s-solution
#8
Argos Soares DE Matos Filho, Andy Petroianu, Valbert Nascimento Cardoso, Paula Vieira Teixeira Vidigal
OBJECTIVE: to evaluate the morphology and function of autogenous splenic tissue implanted in the greater omentum, 24 hours after storage in Ringer-lactate solution. METHODS: we divided 35 male rats into seven groups (n=5): Group 1: no splenectomy; Group 2: total splenectomy without implant; Group 3: total splenectomy and immediate autogenous implant; Group 4: total splenectomy, preservation of the spleen in Ringer-lactate at room temperature, then sliced ​​and implanted; Group 5: total splenectomy, ​​spleen sliced and preserved in Ringer-lactate at room temperature before implantation; Group 6: total splenectomy with preservation of the spleen in Ringer-lactate at 4°C and then sliced ​​and implanted; Group 7: total splenectomy and the spleen sliced for preservation in Ringer-lactate at 4°C before implantation...
2018: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29450973/difference-between-renal-and-splenic-resistive-index-as-a-novel-criterion-in-doppler-evaluation-of-renal-artery-stenosis
#9
Clemens Grupp, Michael J Koziolek, Manuel Wallbach, Kerstin Hoxhold, Gerhard A Müller, Carsten Bramlage
Detection of renal artery stenosis (RAS) using Doppler is difficult to evaluate, particularly under conditions such as bilateral RAS or difficultly accessible renal arteries (RA). The objective of the present study was to assess the utility of splenic arterial compared to renal flow as an additional parameter in the Doppler evaluation of RAS. The difference between the resistive indices (RI) determined in renal and splenic parenchymal arteries (ΔRI K-S ) was evaluated in 181 hypertensive subjects without any evidence of RAS...
February 16, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29450630/outermost-layer-oriented-medial-approach-for-infrapyloric-nodal-dissection-in-laparoscopic-distal-gastrectomy
#10
Susumu Shibasaki, Koichi Suda, Masaya Nakauchi, Tetsuya Nakamura, Shinichi Kadoya, Kenji Kikuchi, Kazuki Inaba, Ichiro Uyama
BACKGROUND: Based on our experience of suprapancreatic nodal dissection in laparoscopic gastrectomy, we developed an outermost layer-oriented medial approach for infrapyloric nodal dissection. The objective of this single-institution retrospective study was to determine the feasibility, safety, and reproducibility of this novel and unique dissection procedure. METHODS: This approach can be performed in the same manner as suprapancreatic nodal dissection but by replacing the left gastric artery with the right gastroepiploic artery (RGEA), the common hepatic artery with the anterior superior pancreaticoduodenal artery (ASPDA), and the splenic artery with the gastroduodenal artery...
February 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29446669/segmental-arterial-mediolysis-abdominal-imaging-of-and-disease-course-in-111-patients
#11
Sailen G Naidu, Christine O Menias, Rahmi Oklu, Robert S Hines, Kinan Alhalabi, Gerges Makar, Fadi E Shamoun, Stanislav Henkin, Robert D McBane
OBJECTIVE: The purpose of this study is to identify the imaging characteristics of segmental arterial mediolysis (SAM) at presentation and establish the longitudinal course of disease. MATERIALS AND METHODS: We retrospectively identified patients with SAM at a single institution from 2000 through 2015. Diagnosis was based on published guidelines with multidisciplinary consensus. Imaging studies obtained at initial evaluation were reviewed to evaluate imaging findings and vascular territory distribution...
February 15, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29445372/robust-phenotypic-activation-of-eosinophils-during-experimental-toxocara-canis-infection
#12
Joice Margareth de Almeida Rodolpho, Luciana Camillo, Márcio Sobreira Silva Araújo, Elaine Speziali, Jordana Grazziela Coelho-Dos-Reis, Ricardo de Oliveira Correia, Débora Meira Neris, Olindo Assis Martins-Filho, Andréa Teixeira-Carvalho, Fernanda de Freitas Anibal
Eosinophils are multifunctional cells that have cytotoxic proinflammatory activities and stimulate CD4 + T-cells in experimental models of allergy and parasitic infections. Eosinophils, when exposed to antigens, are activated, expressing the CD38/CD69 molecules and exhibited increased expression of major histocompatibility complex (MHC-II), CD80 and CD86, suggesting they play a role upon Toxocara canis antigen stimulation. In the present study, we evaluated the profile of eosinophils using conventional and image flow cytometry upon experimental T...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29445365/-babesia-microti-infection-changes-host-spleen-architecture-and-is-cleared-by-a-th1-immune-response
#13
Vitomir Djokic, Lavoisier Akoolo, Nikhat Parveen
Babesia microti is a malaria-like parasite, which infects ∼2000 people annually, such that babesiosis is now a notifiable disease in the United States. Immunocompetent individuals often remain asymptomatic and are tested only after they feel ill. Susceptible C3H/HeJ mice show several human-like disease manifestations and are ideal to study pathogenesis of Babesia species. In this study, we examined parasitemia of B. microti at different time points and assessed its impact on hemoglobin levels in blood, on spleen pathology and overall immune response in C3H/HeJ mice...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29445164/inactivation-of-trpm7-kinase-in-mice-results-in-enlarged-spleens-reduced-t-cell-proliferation-and-diminished-store-operated-calcium-entry
#14
Pavani Beesetty, Krystyna B Wieczerzak, Jennifer N Gibson, Taku Kaitsuka, Charles Tuan Luu, Masayuki Matsushita, J Ashot Kozak
T lymphocytes enlarge (blast) and proliferate in response to antigens in a multistep program that involves obligatory cytosolic calcium elevations. Store-operated calcium entry (SOCE) pathway is the primary source of Ca 2+ in these cells. Here, we describe a novel modulator of blastogenesis, proliferation and SOCE: the TRPM7 channel kinase. TRPM7 kinase-dead (KD) K1646R knock-in mice exhibited splenomegaly and impaired blastogenic responses elicited by PMA/ionomycin or anti-CD3/CD28 antibodies. Splenic T-cell proliferation in vitro was weaker in the mutant compared to wildtype littermates...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445074/intrapancreatic-accessory-spleen-in-a-harbor-porpoise-phocoena-phocoena
#15
Shotaro Nakagun, Josué Díaz-Delgado, Kátia R Groch, Yoshiyasu Kobayashi
The occurrence of accessory spleens in cetacean species is high yet confirmed reports of intrapancreatic accessory spleen, a congenital malformation, remain undescribed. The current study provides the gross, microscopical, histochemical and immunohistochemical features of an intrapancreatic accessory spleen in a harbor porpoise (Phocoena phocoena). Grossly, a 17 × 18 × 9 mm well-demarcated, dark brown to red mass expanded the left pancreatic lobe. Microscopically, this mass consisted of mature splenic tissue interspersed with exocrine pancreatic acini...
February 14, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29444810/disharmonious-patterns-of-heterotaxy-and-isomerism-how-often-are-the-classic-patterns-breached
#16
Deane Yim, Hazumu Nagata, Christopher Z Lam, Lars Grosse-Wortmann, Mike Seed, Edgar Jaeggi, Shi-Joon Yoo
BACKGROUND: It is advocated that heterotaxy should be segregated into right or left isomerism according to atrial appendage morphology. However, atrial situs determination is often based on the pattern of associated findings rather than on atrial morphology itself, which can be difficult to define. The objective was to assess how often concordant patterns of isomerism classified by atrial appendage morphology, bronchopulmonary pattern, and splenic status are breached using cardiac magnetic resonance or computed tomography...
February 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29444633/talaromycosis-penicilliosis-in-a-cynomolgus-macaque
#17
William O Iverson, Subramanya Karanth, Angela Wilcox, Cau D Pham, Shawn R Lockhart, Simone M Nicholson
A sexually mature Chinese-origin female Macaca fascicularis assigned to the high-dose group in a 26-week toxicology study with an experimental immunomodulatory therapeutic antibody (a CD40 L antagonist fusion protein) was euthanized at the scheduled terminal sacrifice on study day 192. The animal was healthy at study initiation and remained clinically normal throughout the study. On study day 141, abnormal clinical pathology changes were found during a scheduled evaluation; splenomegaly was detected on study day 149 and supported by ultrasound examination...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29444079/sensitive-and-less-invasive-confirmatory-diagnosis-of-visceral-leishmaniasis-in-sudan-using-loop-mediated-isothermal-amplification-lamp
#18
Maowia Mukhtar, Sababil S Ali, Salah A Boshara, Audrey Albertini, Séverine Monnerat, Paul Bessell, Yasuyoshi Mori, Yutaka Kubota, Joseph M Ndung'u, Israel Cruz
BACKGROUND: Confirmatory diagnosis of visceral leishmaniasis (VL), as well as diagnosis of relapses and test of cure, usually requires examination by microscopy of samples collected by invasive means, such as splenic, bone marrow or lymph node aspirates. This causes discomfort to patients, with risks of bleeding and iatrogenic infections, and requires technical expertise. Molecular tests have great potential for diagnosis of VL using peripheral blood, but require well-equipped facilities and trained personnel...
February 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29438854/thrombosis-of-the-spleno-mesentiric-portal-axis-following-laparoscopic-sleeve-gastrectomy-a-rare-case-report
#19
Saleh Alshreadah, Rasees Alotaibi, Abdulaziz Aldabaeab, Ibrahim Alhafid
INTRODUCTION: Mesenteric, splenic and portal veins thrombosis (MSPVT) is uncommon complication after sleeve gastrectomy. CASE REPORT: A 38-year-old female underwent laparoscopic sleeve gastrectomy (LSG) for the treatment of morbid obesity, presented 4 weeks later with epigastric pain. Computed tomography (CT) scan revealed superior mesenteric, splenic and the portal veins thrombosis. CONCLUSION: MSPVT is a rare presentation after laparoscopic sleeve gastrectomy, which requires early diagnosis and management and it should be included in the differential diagnosis for unexplained abdominal symptoms after laparoscopic sleeve gastrectomy...
February 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29438774/palliative-effects-of-moringa-olifera-ethanolic-extract-on-hemato-immunologic-impacts-of-melamine-in-rats
#20
Yasmina M Abd-Elhakim, Khlood M El Bohi, Sahar Khalifa Hassan, Shorouk El Sayed, Sabry M Abd-Elmotal
Melamine (MEL) is a widespread food contaminant and adulterant. Moringa olifera is a widely known medicinal plant with various pharmacological properties. Herein, this study aimed to investigate, for the first time, the probable protective or therapeutic role of M. olifera ethanolic extract (MOE) against MEL induced hemato-immune toxic hazards. Fifty Sprague Dawely male rats were orally treated with distilled water, MOE (800 mg/kg bw), MEL (700 mg/kg bw), MOE/MEl or MOE + MEl. Erythrogram and leukogram profiling were evaluated to assess hematological status...
February 10, 2018: Food and Chemical Toxicology
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