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https://www.readbyqxmd.com/read/29782391/impact-of-age-on-the-association-between-24-h-ambulatory-blood-pressure-measurements-and-target-organ-damage
#1
Thomas B Olesen, Manan Pareek, Jacob V Stidsen, Marie K Blicher, Susanne Rasmussen, Julie K K Vishram-Nielsen, Kathrine Kjaer-Hansen, Michael H Olsen
OBJECTIVE: The aim of this study was to evaluate the impact of age on the associations between hemodynamic components derived from 24-h ambulatory blood pressure (24-h ABPM) and target organ damage, in apparently healthy, nonmedicated individuals. METHODS: Twenty-four-hour ABPM and target organ damage (left ventricular mass index, pulse wave velocity, urine albumin : creatinine ratio and carotid atherosclerotic plaques) were evaluated in 1408 individuals. Associations were examined in regression models, stratified for age [middle-aged (41 or 51 years) or elderly (61 or 71 years)], and adjusted for sex, smoking status, and total-cholesterol...
May 17, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29752131/effectiveness-of-the-dtpa-hbv-ipv-hib-vaccine-against-invasive-haemophilus-influenzae-type-b-disease-in-the-netherlands-2003-16-a-case-control-study
#2
Susana Monge, Susan Jm Hahné, Hester E de Melker, Elisabeth Am Sanders, Arie van der Ende, Mirjam J Knol
BACKGROUND: In 2016, an increase in invasive Haemophilus influenzae serotype b (Hib) disease was reported in the Netherlands in children younger than 5 years, which coincided with the introduction of the hexavalent diphtheria, tetanus, and acellular pertussis-hepatitis B virus-inactivated polio virus/Hib vaccine (DTPa-HBV-IPV/Hib) from 2011 onwards. We aimed to estimate the effectiveness of the hexavalent vaccine to assess whether this increase could be explained by decreasing effectiveness...
May 8, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29735425/discovery-of-tetrahydroindazoles-as-a-novel-class-of-potent-and-in-vivo-efficacious-gamma-secretase-modulators
#3
Kai Gerlach, Scott Hobson, Christian Eickmeier, Ulrike Groß, Clemens Braun, Peter Sieger, Michel Garneau, Stefan Hoerer, Niklas Heine
The identification and optimization of a novel series of centrally efficacious gamma secretase modulators (GSMs) offering an alternative to the privileged aryl imidazole motif is described. Chiral bicyclic tetrahydroindazolyl amine substituted triazolopyridines were identified as structurally distinct novel series of GSMs. Representative compound BI-1408 ((R)-42) was demonstrated to be centrally efficacious in rats at a 30 mg/kg oral dose.
April 30, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29725984/meta-analysis-of-the-association-between-gaba-receptor-polymorphisms-and-autism-spectrum-disorder-asd
#4
REVIEW
Manijeh Mahdavi, Majid Kheirollahi, Roya Riahi, Fariborz Khorvash, Mehdi Khorrami, Maryam Mirsafaie
Previous studies have reported the association of GABA receptor subunits B3, A5, and G3 single-nucleotide polymorphisms (SNPs) in chromosome 15q11-q13 with autism spectrum disorders (ASDs). However, the currently available results are inconsistent. This study aimed to investigate the association between ASD and the GABA receptor SNPs in chromosomal region 15q11-q13. The association was calculated by the overall odds ratio (OR) with a 95% confidence interval (CI). We used sensitivity analyses and the assessment of publication bias in our meta-analysis...
May 3, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29718465/proteinase-3-and-myeloperoxidase-serotype-in-relation-to-demographic-factors-and-geographic-distribution-in-anti-neutrophil-cytoplasmic-antibody-associated-glomerulonephritis
#5
Maria Weiner, Rune Bjørneklett, Zdenka Hrušková, Bruce Mackinnon, Caroline J Poulton, Leo Sindelar, Aladdin J Mohammad, Per Eriksson, Loreto Gesualdo, Duvuru Geetha, Matija Crnogorac, David Jayne, Susan L Hogan, Colin Geddes, Vladimir Tesar, Knut Aasarød, Mårten Segelmark
Background: In anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, antigen specificity varies between myeloperoxidase (MPO) and proteinase 3 (PR3). This has been reported to vary in relation to age, gender, geography and extrarenal manifestations. However, studies are difficult to compare as criteria for inclusion vary. The aim of this study was to investigate the relationship between ANCA serotype, latitude, ultraviolet (UV) radiation levels, age, gender and renal function at diagnosis in a large study with uniform inclusion criteria...
April 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29696390/treatment-costs-and-cost-drivers-among-osteoporotic-fracture-patients-in-japan-a-retrospective-database-analysis
#6
Yurie Taguchi, Yuta Inoue, Taichi Kido, Nobuhiro Arai
This study estimated the direct medical costs of osteoporotic fractures from a large claim database in Japan. We further identified several comorbidities which drove the treatment costs. The results would contribute to health economic analysis as well as understanding of individual financial burden in Japan. INTRODUCTION: The purposes of this study were to estimate treatment costs of osteoporotic fractures and to investigate the cost drivers. METHODS: Male and female patients aged 50 years and older with a hip, vertebral, or non-hip/non-vert (NHNV) fracture between April 2008 and December 2016 were analyzed from claim database...
April 25, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29680662/insulin-sensitivity-linked-skeletal-muscle-nr4a1-dna-methylation-is-programmed-by-the-maternal-diet-and-modulated-by-voluntary-exercise-in-mice
#7
Juliane Kasch, Isabel Kanzleiter, Sophie Saussenthaler, Annette Schürmann, Jaap Keijer, Evert van Schothorst, Susanne Klaus, Sara Schumann
Perinatal maternal high-fat consumption is known to increase the obesity and type 2 diabetes susceptibility and to impair exercise performance in the offspring. We hypothesize that epigenetic modifications in the skeletal muscle are partly responsible for this phenotype. To detect skeletal muscle genes affected by maternal nutrition, male offspring of low-fat (LF) and high-fat (HF) diet fed dams (BL6 mice) received LF diet upon weaning and were sacrificed at 6 or 25 weeks of age. Gene expression of Musculus quadriceps was investigated by microarray analysis revealing an up-regulation of the nuclear receptor Nr4a1 by maternal HF feeding...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29678798/analysis-of-college-students-personal-health-information-activities-online-survey
#8
Sujin Kim, Donghee Sinn, Sue Yeon Syn
BACKGROUND: With abundant personal health information at hand, individuals are faced with a critical challenge in evaluating the informational value of health care records to keep useful information and discard that which is determined useless. Young, healthy college students who were previously dependents of adult parents or caregivers are less likely to be concerned with disease management. Personal health information management (PHIM) is a special case of personal information management (PIM) that is associated with multiple interactions among varying stakeholders and systems...
April 20, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29669538/predictors-of-women-s-utilization-of-primary-health-care-for-skilled-pregnancy-care-in-rural-nigeria
#9
Friday Okonofua, Lorretta Ntoimo, Julius Ogungbangbe, Seun Anjorin, Wilson Imongan, Sanni Yaya
BACKGROUND: Although Primary Health Care (PHC) was designed to provide universal access to skilled pregnancy care for the prevention of maternal deaths, very little is known of the factors that predict the use of PHC for skilled maternity care in rural parts of Nigeria - where its use is likely to have a greater positive impact on maternal health care. The objective of this study was to identify the factors that lead pregnant women to use or not use existing primary health care facilities for antenatal and delivery care...
April 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29666478/two-new-spliceostatin-analogs-from-the-strain-pseudomonas-sp-hs-nf-1408
#10
Yue Zhao, Junwei Zhao, Chang Lu, Hui Zhang, Huan Qi, Shanwen Jiang, Xiaowei Guo, Jidong Wang, Wensheng Xiang
Two new spliceostatin derivatives, designed as spliceostatin H (1) and spliceostatin I (2), and one known compound FR901464 (3), were isolated from the strain Pseudomonas sp. HS-NF-1408. Their structures were determined by the comprehensive spectroscopic data, including 1D, 2D NMR, MS spectral analysis and comparison with data from the literature. Compound 1 exhibited potent cytotoxicity activity against A549 and HepG2 with IC50 values of 3.57 and 16.72 μg/ml, respectively.
April 17, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29588494/global-negative-effects-of-nitrogen-deposition-on-soil-microbes
#11
Tian'an Zhang, Han Y H Chen, Honghua Ruan
Soil microbes comprise a large portion of the genetic diversity on Earth and influence a large number of important ecosystem processes. Increasing atmospheric nitrogen (N) deposition represents a major global change driver; however, it is still debated whether the impacts of N deposition on soil microbial biomass and respiration are ecosystem-type dependent. Moreover, the extent of N deposition impacts on microbial composition remains unclear. Here we conduct a global meta-analysis using 1408 paired observations from 151 studies to evaluate the responses of soil microbial biomass, composition, and function to N addition...
March 27, 2018: ISME Journal
https://www.readbyqxmd.com/read/29530002/time-to-diagnosis-and-associated-costs-of-an-outpatient-vs-inpatient-setting-in-the-diagnosis-of-lymphoma-a-retrospective-study-of-a-large-cohort-of-major-lymphoma-subtypes-in-spain
#12
Xavier Bosch, Carmen Sanclemente-Ansó, Ona Escoda, Esther Monclús, Jonathan Franco-Vanegas, Pedro Moreno, Mar Guerra-García, Neus Guasch, Alfons López-Soto
BACKGROUND: Mainly because of the diversity of clinical presentations, diagnostic delays in lymphoma can be excessive. The time spent in primary care before referral to the specialist may be relatively short compared with the interval between hospital appointment and diagnosis. Although studies have examined the diagnostic intervals and referral patterns of patients with lymphoma, the time to diagnosis of outpatient compared to inpatient settings and the costs incurred are unknown. METHODS: We performed a retrospective study at two academic hospitals to evaluate the time to diagnosis and associated costs of hospital-based outpatient diagnostic clinics or conventional hospitalization in four representative lymphoma subtypes...
March 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29516953/-in-silico-identification-of-potent-small-molecule-inhibitors-targeting-epidermal-growth-factor-receptor-1
#13
Zheng Shi, Jie Chen, Xiaolan Guo, Lijia Cheng, Xiaoheng Guo, Tian Yu
Background: The receptor tyrosine kinase of the epidermal growth factor receptor (EGFR, ErbB) family played an important role in multisignaling pathways, which controlled numerous biological activities including proliferation, differentiation, apoptosis, etc. EGFR abnormalities have been associated with a variety of human tumors, which was a well-characterized target for cancer treatment. It was known to all that drug repositioning has been considered as a useful tool to accelerate the process of drug development...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29449720/biallelic-inactivating-variants-in-the-gtpbp2-gene-cause-a-neurodevelopmental-disorder-with-severe-intellectual-disability
#14
Aida M Bertoli-Avella, Jose M Garcia-Aznar, Oliver Brandau, Fahad Al-Hakami, Zafer Yüksel, Anett Marais, Nana-Maria Grüning, Lia Abbasi Moheb, Omid Paknia, Nahla Alshaikh, Seham Alameer, Makia J Marafi, Fahd Al-Mulla, Nouriya Al-Sannaa, Arndt Rolfs, Peter Bauer
Congenital neurological disorders are genetically highly heterogeneous. Rare forms of hereditary neurological disorders are still difficult to be adequately diagnosed. Pertinent studies, especially when reporting only single families, need independent confirmation. We present three unrelated families in which whole-exome sequencing identified the homozygous non-sense variants c.430[C>T];[C>T] p.(Arg144*), c.1219[C>T];[C>T] p.(Gln407*) and c.1408[C>T];[C>T] p.(Arg470*) in GTPBP2. Their clinical presentations include early onset and apparently non-progressive motor and cognitive impairment, and thereby overlap with findings in a recently described family harbouring a homozygous GTPBP2 splice site variant...
April 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29410107/laparoscopic-vs-transvaginal-cuff-closure-after-total-laparoscopic-hysterectomy-a-randomized-trial-by-the-italian-society-of-gynecologic-endoscopy
#15
Stefano Uccella, Mario Malzoni, Antonella Cromi, Renato Seracchioli, Giuseppe Ciravolo, Francesco Fanfani, Fevzi Shakir, Salvatore Gueli Alletti, Francesco Legge, Roberto Berretta, Giacomo Corrado, Lucia Casarella, Paolo Donarini, Margherita Zanello, Emanuele Perrone, Baldo Gisone, Enrico Vizza, Giovanni Scambia, Fabio Ghezzi
BACKGROUND: Vaginal cuff dehiscence following hysterectomy is considered an infrequent but potentially devastating complication. Different possible techniques for cuff closure have been proposed to reduce this threatening adverse event. OBJECTIVE: The aim of the present randomized study was to compare laparoscopic and transvaginal suture of the vaginal vault at the end of a total laparoscopic hysterectomy, in terms of incidence of vaginal dehiscence and vaginal cuff complications...
May 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29399706/differential-diagnostic-perspectives-provided-by-en-face-microscopic-examination-of-articular-surface-defects
#16
Bruce M Rothschild
Surface defects have a central position in diagnosis of articular pathology. Recognizing the limitations of standard radiologic techniques and those imposed by positioning and averaging artifacts on CT evaluation, direct visualization of surface defects was pursued to identify disease characteristics that would facilitate interpretation of radiologic findings. Epi-illumination surface microscopy was utilized to examine macroscopically recognized articular surface defects in individuals in the Hamann-Todd, Terry, and Huntington human skeletal collections with previously verified diagnoses of rheumatoid arthritis, spondyloarthropathy, juvenile inflammatory arthritis (JIA), calcium pyrophosphate deposition disease (CPPD), gout, metastatic cancer, multiple myeloma, septic arthritis, tuberculosis, fungal arthritis, histiocytosis and sickle cell anemia (Rothschild and Rothschild Clin Infect Dis 20(5):1402-1408, 1995; Rothschild et al...
March 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29381687/enrolling-children-with-acute-lymphoblastic-leukaemia-on-a-clinical-trial-improves-event-free-survival-a-population-based-study
#17
Caron Strahlendorf, Jason D Pole, Randy Barber, David Dix, Ketan Kulkarni, Emilie Martineau, Alicia Randall, David Stammers, Douglas Strother, Tony H Truong, Lillian Sung
BACKGROUND: The objectives of this study were to describe the impact of trial enrollment at diagnosis on event-free and overall survival in paediatric acute lymphoblastic leukaemic (ALL) using a population-based approach. METHODS: We conducted a retrospective cohort study that included children newly diagnosed with ALL between 1 and 14 years of age. The data source was the Cancer in Young People in Canada (CYP-C) national paediatric cancer population-based database...
March 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29359444/three-patients-with-schaaf-yang-syndrome-exhibiting-arthrogryposis-and-endocrinological-abnormalities
#18
Takuji Enya, Nobuhiko Okamoto, Yoshinori Iba, Tomoki Miyazawa, Mitsuru Okada, Shinobu Ida, Takuya Naruto, Issei Imoto, Atsushi Fujita, Noriko Miyake, Naomichi Matsumoto, Keisuke Sugimoto, Tsukasa Takemura
MAGEL2 is the paternally expressed gene within Prader-Willi syndrome critical region at 15q11.2. We encountered three individuals in whom truncating mutations of MAGEL2 were identified. Patients 1 and 2, siblings born to healthy, non-consanguineous Japanese parents, showed generalized hypotonia, lethargy, severe respiratory difficulty, poor feeding, and multiple anomalies including arthrogryposis soon after birth. We carried out whole-exome sequencing, which detected a MAGEL2 mutation (c.1912C>T, p.Gln638*, heterozygous)...
March 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29353085/reactions-of-a-tetranuclear-pt-thiosemicarbazone-complex-with-model-proteins
#19
Tiziano Marzo, Francisco Navas, Damiano Cirri, Antonello Merlino, Giarita Ferraro, Luigi Messori, Adoracion G Quiroga
The tetranuclear Pt complex (PtL)4 (where L2- is the anion derived from para-isopropyl thiosemicarbazone) was first described in A.G. Quiroga et al., J. Med. Chem. 41, 1998, 1399-1408. (PtL)4 manifests antiproliferative properties toward various cancer cell lines being a promising anticancer drug candidate. Yet, details of its reactivity with biomolecules have not been elucidated. To this end, we investigated the reactions of (PtL)4 with a few model proteins, i.e. bovine pancreatic ribonuclease (RNase A), cytochrome c (Cyt c) and hen egg white lysozyme (Lysozyme), through electrospray ionization mass spectrometry and other biophysical methods...
April 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29305624/evidence-of-a-liver-alpha-cell-axis-in-humans-hepatic-insulin-resistance-attenuates-relationship-between-fasting-plasma-glucagon-and-glucagonotropic-amino-acids
#20
Nicolai J Wewer Albrechtsen, Kristine Færch, Troels M Jensen, Daniel R Witte, Jens Pedersen, Yuvaraj Mahendran, Anna E Jonsson, Katrine D Galsgaard, Marie Winther-Sørensen, Signe S Torekov, Torsten Lauritzen, Oluf Pedersen, Filip K Knop, Torben Hansen, Marit E Jørgensen, Dorte Vistisen, Jens J Holst
AIMS/HYPOTHESIS: The secretion of glucagon is controlled by blood glucose and inappropriate secretion of glucagon contributes to hyperglycaemia in diabetes. Besides its role in glucose regulation, glucagon regulates amino acid metabolism in hepatocytes by increasing ureagenesis. Disruption of this mechanism causes hyperaminoacidaemia, which in turn increases glucagon secretion. We hypothesised that hepatic insulin resistance (secondary to hepatic steatosis) via defective glucagon signalling/glucagon resistance would lead to impaired ureagenesis and, hence, increased plasma concentrations of glucagonotropic amino acids and, subsequently, glucagon...
March 2018: Diabetologia
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