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Taina T Nieminen, Walter Pavicic, Noora Porkka, Matti Kankainen, Heikki J Järvinen, Anna Lepistö, Päivi Peltomäki
Allele-specific expression (ASE) of the Adenomatous Polyposis Coli (APC) gene occurs in up to one-third of families with adenomatous polyposis (FAP) that have screened mutation-negative by conventional techniques. To advance our understanding of the genomic basis of this phenomenon, 54 APC mutation-negative families (21 with classical FAP and 33 with attenuated FAP, AFAP) were investigated. We focused on four families with validated ASE and scrutinized these families by sequencing of the blood transcriptomes (RNA-seq) and genomes (WGS)...
September 23, 2016: Oncotarget
Carolin Ludwig, Anno de Jong, Hilde Moyaert, Farid El Garch, Regina Janes, Ulrich Klein, Ian Morrissey, Julien Thiry, Myriam Youala
AIMS: The ComPath project is a pan-European programme dedicated to the monitoring of antimicrobial susceptibility of pathogens from diseased dogs and cats using standardized methods and centralized MIC determination. Here, the susceptibility of major pathogens is reported from antimicrobial non-treated animals with acute clinical signs of skin, wound or ear infections in 2008-2010. METHODS AND RESULTS: MICs were determined by agar dilution for commonly used antibiotics and interpreted using CLSI breakpoints, if available...
September 4, 2016: Journal of Applied Microbiology
Neeru Singh, Praveen K Bharti, N S Kumre
Balaghat district in Central India is characterized by perennial malaria transmission. In this study, we have estimated malaria parasite rates by microscopic examination of blood smears by conducting active (ACD) and passive surveillance (PCD) in the villages of Baihar community health center (CHC) during January 2012-December 2012. Comparison of the results of two methods revealed that ACD (active case detection) in villages provides relatively large numbers of malaria positive cases (1408/3601) as compared to PCD (passive case detection) at CHC (139/2743) (OR 12...
June 2016: Pathogens and Global Health
Malin Skagerlind, Bernd Stegmayr
Introduction Intermittent hemodialysis (IHD) is sometimes necessary in patients with a bleeding risk, i.e., before/after surgery or brain hemorrhage. In such case IHD has to be modified to limit the conventional anticoagulation used to avoid clotting of the extracorporeal circuit (ECC). We evaluated if priming using a heparin and albumin (HA) mixture could minimize the exposure to heparin. Methods Retrospective data from 1995 to 2013 were collected from 1408 acute dialysis treatment protocols that included 321 patients...
August 31, 2016: Hemodialysis International
Rachel Sutherland, Penny Reeves, Elizabeth Campbell, David R Lubans, Philip J Morgan, Nicole Nathan, Luke Wolfenden, Anthony D Okely, Karen Gillham, Lynda Davies, John Wiggers
BACKGROUND: Few school-based interventions have been successful in reducing physical activity decline and preventing overweight and obesity in adolescent populations. As a result, few cost effectiveness analyses have been reported. The aim of this paper is to report the cost and cost effectiveness of the Physical Activity 4 Everyone (PA4E1) intervention which was a multi-component intervention implemented in secondary schools located in low-income communities. Cost effectiveness was assessed using both the physical activity and weight status trial outcomes...
2016: International Journal of Behavioral Nutrition and Physical Activity
Irfan Ullah, Aamer Ali Shah, Anila Basit, Mazhar Ali, Afsar Khan, Ubaid Ullah, Muhammad Ihtesham, Sumaira Mehreen, Anita Mughal, Arshad Javaid
BACKGROUND: Multi-drug resistant tuberculosis (MDR-TB) is a major public health problem especially in developing countries. World Health Organization (WHO) recommends use of Xpert MTB/RIF assay to simultaneously detecting Mycobacterium tuberculosis (MTB) and rifampicin (RIF) resistance. The primary objective of this study was to determine the frequency of MDR-TB in patients suspected to have drug resistance in Khyber Pakhtunkhwa. The frequency of probes for various rpoB gene mutations using Xpert MTB/RIF assay within 81 bp RRDR (Rifampicin Resistance Determining Region) was the secondary objective...
2016: BMC Infectious Diseases
Henrik Fox, Hans-Christian Purucker, Isabelle Holzhacker, Ulrich Tebtmann, Thomas Bitter, Dieter Horstkotte, Andrea Graml, Holger Woehrle, Olaf Oldenburg
PURPOSE: Coronary artery disease (CAD) is a leading cause of death and identification of risk factors for CAD is crucial. One such potential risk factor is sleep-disordered breathing (SDB). This prospective cohort study investigated the prevalence of SDB and determined risk factors for the presence of SDB in a large CAD cohort undergoing cardiac rehabilitation. METHODS: A total of 1425 patients with confirmed CAD starting rehabilitation were screened for SDB using cardiorespiratory polygraphy (n = 921) or polygraphy plus pulse oximetry (n = 484)...
August 3, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
Shweta Shah, Abbey C Thomas, Joshua M Noone, Christopher M Blanchette, Erik A Wikstrom
BACKGROUND: Ankle sprains represent a common injury in emergency departments, but little is known about common complications, procedures, and charges associated with ankle sprains in emergency departments. HYPOTHESIS: There will be a higher incidence of ankle sprains among younger populations (≤25 years old) and in female patients. Complications and procedures will differ between ankle sprain types. Lateral ankle sprains will have lower health care charges relative to medial and high ankle sprains...
July 29, 2016: Sports Health
Robert E Wiggins, Rebecca Etz
IMPORTANCE: There is disagreement as to whether Maintenance of Certification is creating value for physicians and their patients. To our knowledge, this report provides the first measures of the effectiveness of Part 4 of this activity in assisting ophthalmologists with quality improvement in their practices. OBJECTIVE: To evaluate the effectiveness of the American Board of Ophthalmology's quality improvement program-Maintenance of Certification Part 4 (Improvement in Medical Practice)-in assisting its diplomates with quality improvement in their practices...
September 1, 2016: JAMA Ophthalmology
Ingrid Bader, E Decker, J A Mayr, V Lunzer, J Koch, E Boltshauser, W Sperl, P Pietsch, B Ertl-Wagner, H Bolz, C Bergmann, O Rittinger
Joubert syndrome (JS) is a clinically and genetically heterogeneous ciliopathy characterized by episodic hyperpnea and apnea, hypotonia, ataxia, cognitive impairment and ocular motor apraxia. The "molar tooth sign" is pathognomonic of this condition. Mutations in the MKS1 gene are a major cause of Meckel-Gruber syndrome (MKS), the most common form of syndromic neural tube defects, frequently resulting in perinatal lethality. We present the phenotype and genotype of a child with severe JS and agenesis of the corpus callosum (ACC)...
August 2016: European Journal of Medical Genetics
Molly P O'Sullivan, Matthew R Nagy, Shannon S Block, Trevor R Tooley, Rebecca E Hasson
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Maricela Maldonado, Gerardo Ico, Karen Low, Rebeccah J Luu, Jin Nam
Electrospun scaffolds provide soft nanofibrous networks pliable by human induced pluripotent stem cells. J. Nam and co-workers show on page 1408 that such compliant scaffolding leads to the formation of stem cell colonies with a distinctive three-dimensional morphology. The morphological modulation resulted in the lineage-specific differentiation, suggesting a potential means to enhance translational applications of the stem cells.
June 2016: Advanced Healthcare Materials
Chiara Curreri, Valter Giantin, Nicola Veronese, Caterina Trevisan, Leonardo Sartori, Estella Musacchio, Sabina Zambon, Stefania Maggi, Egle Perissinotto, Maria Chiara Corti, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
We studied a cohort of 1408 older subjects to explore whether postural changes in blood pressure (BP; defined as orthostatic hypo- or hypertension) can predict the onset of cognitive deterioration. Orthostatic hypotension was defined as a drop of 20 mm Hg in systolic or 10 mm Hg in diastolic BP and orthostatic hypertension as a rise of 20 mm Hg in systolic BP. Orthostatic BP values were grouped into quintiles for secondary analyses. Two cognitive assessments were considered: (1) cognitive impairment, that is, Mini-Mental State Examination scores ≤24/30, and (2) cognitive decline (CD), that is, a 3-point decrease in Mini-Mental State Examination score from the baseline to the follow-up...
August 2016: Hypertension
Jonas Ockell, Anna Elander, Trude Staalesen, Monika Fagevik Olsén
BACKGROUND: Little is known about excess skin in the normal population. The aim of this study was, therefore, to analyse the prevalence, impairments, and discomfort of excess skin in a cross-section of the Swedish population. METHODS: From the population registry of the Swedish Tax Agency, 1408 subjects living in Västra Götaland County from 18-59 years of age were randomly selected with an equal distribution of the sexes. Additionally, age was equally distributed, although twice as many subjects under 40 years of age were sent the questionnaire due to an expected low response rate for younger people...
June 10, 2016: Journal of Plastic Surgery and Hand Surgery
Nayoung Sung, Joanne Kwak-Kim, H S Koo, K M Yang
PURPOSE: To investigate hCG-β level on postovulatory day (POD) 12 and its fold increase as predictors for pregnancy outcome after in vitro fertilization (IVF) cycles. METHODS: A retrospective cohort study was performed in total 1408 fresh and 598 frozen cycles between November 2008 and October 2011, which resulted in biochemical pregnancy, early pregnancy loss, or live birth of singleton pregnancy. The serum hCG-β levels of POD 12 and 14 were compared among biochemical pregnancy, early pregnancy loss, and live birth groups...
September 2016: Journal of Assisted Reproduction and Genetics
Suzanne C Schiffman, Shira Abberbock, Sharon Winters, Cindy Valko, Jennifer Steve, Amer H Zureikat, Herbert J Zeh, Melissa E Hogg
BACKGROUND: The purpose of this study was to evaluate the impact of a multidisciplinary clinic (MDC) on the treatment of pancreatic ductal adenocarcinoma. We hypothesized that an MDC would improve trial participation, multimodality therapy, neoadjuvant therapy, time to treatment, and survival. MATERIALS AND METHODS: Pancreatic ductal adenocarcinoma cancer registry patients from 2008-2012 were analyzed. Outcomes of patients evaluated at the MDC were compared with patients not evaluated at the MDC (non-MDC)...
May 15, 2016: Journal of Surgical Research
Takayuki Katsube, Toru Ishibashi, Takeshi Kano, Toshihiro Wajima
OBJECTIVES: The aim of this study was to develop a population pharmacokinetic (PK)/pharmacodynamic (PD) model for describing plasma lusutrombopag concentrations and platelet response following oral lusutrombopag dosing and for evaluating covariates in the PK/PD profiles. METHODS: A population PK/PD model was developed using a total of 2539 plasma lusutrombopag concentration data and 1408 platelet count data from 78 healthy adult subjects following oral single and multiple (14-day once-daily) dosing...
May 21, 2016: Clinical Pharmacokinetics
M J Arnett, R J Thorpe, D J Gaskin, J V Bowie, T A LaVeist
Compared to White Americans, African-Americans are less likely to use primary care (PC) as their usual source of care. This is generally attributed to race differences in socioeconomic status and in access to primary care services. Little is known about the relationship between race differences in medical mistrust and the usual source of care disparity. Using data from the Exploring Health Disparities in Integrated Communities (EHDIC) study, we examined the role of medical mistrust in choosing usual source of care in 1408 black and white adults who were exposed to the same healthcare facilities and low-income racially integrated community...
June 2016: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Elizabeth X Zheng, Simona Rossi, Robert J Fontana, Raj Vuppalanchi, Jay H Hoofnagle, Ikhlas Khan, Victor J Navarro
INTRODUCTION: Herbal and dietary supplements (HDS) have been increasingly recognized as a cause for acute liver injury (Navarro et al. Hepatology 60(4):1399-1408, 2014; Bailey et al. J Nutr 141:261-266, 2011). HDS products frequently contain numerous ingredients, and are marketed under various product names. A perusal of marketed weight loss products indicates that green tea extract (GTE) is a common ingredient in many. We aimed to describe the course and outcome of six patients who developed liver injury attributed to SLIMQUICK(®) weight loss products...
August 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Lionel Perrier, Magali Morelle, Pascal Pommier, Pierre Boisselier, Bernard Coche-Dequeant, Olivier Gallocher, Marc Alfonsi, Etienne Bardet, Michel Rives, Valentin Calugaru, Enrique Chajon, Georges Noel, Hinda Mecellem, David Pérol, Sophie Dussart, Philippe Giraud
PURPOSE: This cost analysis aimed to prospectively assess differences in costs between TomoTherapy and volumetric modulated arc therapy (VMAT) in patients with head and neck cancer. METHODS AND MATERIALS: Economic data were gathered from a multicenter study. However, randomization was not possible due to the availability of equipment. Costs were calculated using the microcosting technique from the hospital's perspective (in 2013 euros), and the time horizon was radiation therapy...
June 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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