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https://www.readbyqxmd.com/read/28207778/neutrophil-gelatinase-associated-lipocalin-levels-are-u-shaped-in-the-ludwigshafen-risk-and-cardiovascular-health-luric-study-impact-for-mortality
#1
Rainer P Woitas, Hubert Scharnagl, Marcus E Kleber, Graciela E Delgado, Tanja B Grammer, Martin Pichler, Bernhard K Krämer, Winfried März, Tatjana Stojakovic
INTRODUCTION: Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein released by damaged renal tubular cells and mature neutrophils. It is elevated in kidney injury, but also in patients with coronary artery disease (CAD) and myocardial infarction. We investigated the prognostic value of NGAL for total and cardiovascular mortality in patients undergoing coronary angiography without history of renal insufficiency at inclusion into the study. PARTICIPANTS: The LURIC study is an ongoing prospective cohort study of patients referred for coronary angiography and is designed to evaluate determinants of cardiovascular health...
2017: PloS One
https://www.readbyqxmd.com/read/28204971/the-presence-of-cancerous-nodules-in-lymph-nodes-is-a-novel-indicator-of-distant-metastasis-and-poor-survival-in-patients-with-papillary-thyroid-carcinoma
#2
Ling Chen, Youzhi Zhu, Ke Zheng, Huihao Zhang, Hongkun Guo, Li Zhang, Kunlin Wu, Lingjun Kong, Weihong Ruan, Jianying Hu, Xin Zhang, Xiangjin Chen
PURPOSE: Several characteristics of lymph node metastasis (LNM) as predictors of the risk of recurrence or death were examined in patients with papillary thyroid carcinoma (PTC). The presence of cancerous nodules as a characteristic of LNMs in PTC has not yet been reported. The objective of this study was to evaluate the use of the cancerous nodules in the lymph node (CNLN) to determine the risk of distant metastasis and survival in patients with PTC. METHODS: This retrospective observational cohort study enrolled 1408 patients with pathologically confirmed PTC without initial distant metastasis who underwent thyroidectomy and neck dissection...
February 15, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28173844/differential-long-noncoding-rna-mrna-expression-profiling-and-functional-network-analysis-during-osteogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells
#3
Wenyuan Zhang, Rui Dong, Shu Diao, Juan Du, Zhipeng Fan, Fu Wang
BACKGROUND: Mesenchymal stem cells (MSCs) are the most promising cell types for bone regeneration and repair due to their osteogenic potential. MSC differentiation is precisely regulated and orchestrated by the mechanical and molecular signals from the extracellular environment, involving complex pathways regulated at both the transcriptional and post-transcriptional levels. However, the potential role of long noncoding RNA (lncRNA) in the osteogenic differentiation of human MSCs remains largely unclear...
February 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28157083/effect-of-perioperative-bacteriological-safety-on-hip-joint-infection-after-hip-replacement
#4
Iwona Morawik, Mirosław Jabłoński
BACKGROUND: In terms of clinical importance, deep infections are the most severe and problematic complications of hip replacement, and limiting the risk of these complications continues to pose a medical and organisational challenge. The aim of this retrospective study was to compare the incidence of early deep infection after hip arthroplasty in two 5-year periods separated by a long interval (1985-1989 and 2005-2009) with respect to analysing changes in the conditions of perioperative bacteriological safety...
May 5, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28134427/preliminary-estimates-of-the-economic-implications-of-addiction-in-the-united-arab-emirates
#5
C M Doran
This study aimed to provide preliminary estimates of the economic implications of addiction in the United Arab Emirates (UAE). Local and international data sources were used to derive estimates of substancerelated healthcare costs, lost productivity and criminal behaviour. From an estimated population of 8.26 million: ~1.47 million used tobacco (20.5% of adults); 380 085 used cannabis (> 5%); 14 077 used alcohol in a harmful manner (0.2%); and 1408 used opiates (0.02%). The cost of addiction was estimated at US$ 5...
January 23, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28115532/marginal-prescription-equivalent-to-the-isocenter-prescription-in-lung-stereotactic-body-radiotherapy-preliminary-study-for-japan-clinical-oncology-group-trial-jcog1408
#6
Daisuke Kawahara, Shuichi Ozawa, Tomoki Kimura, Akito Saito, Teiji Nishio, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
A new randomized Phase III trial, the Japan Clinical Oncology Group (JCOG) 1408, which compares two dose fractionations (JCOG 0403 and JCOG 0702) for medically inoperable Stage IA NSCLC or small lung lesions clinically diagnosed as primary lung cancer, involves the introduction of a prescribed dose to the D95% of the planning target volume (PTV) using a superposition/convolution algorithm. Therefore, we must determine the prescribed dose in the D95% prescribing method to begin JCOG1408. JCOG 0702 uses density correction and the D95% prescribing method...
January 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28097368/incidence-of-and-risk-factors-for-skin-cancer-in-organ-transplant-recipients-in-the-united-states
#7
Giorgia L Garrett, Paul D Blanc, John Boscardin, Amanda Abramson Lloyd, Rehana L Ahmed, Tiffany Anthony, Kristin Bibee, Andrew Breithaupt, Jennifer Cannon, Amy Chen, Joyce Y Cheng, Zelma Chiesa-Fuxench, Oscar R Colegio, Clara Curiel-Lewandrowski, Christina A Del Guzzo, Max Disse, Margaret Dowd, Robert Eilers, Arisa Elena Ortiz, Caroline Morris, Spring K Golden, Michael S Graves, John R Griffin, R Samuel Hopkins, Conway C Huang, Gordon Hyeonjin Bae, Anokhi Jambusaria, Thomas A Jennings, Shang I Brian Jiang, Pritesh S Karia, Shilpi Khetarpal, Changhyun Kim, Goran Klintmalm, Kathryn Konicke, Shlomo A Koyfman, Charlene Lam, Peter Lee, Justin J Leitenberger, Tiffany Loh, Stefan Lowenstein, Reshmi Madankumar, Jacqueline F Moreau, Rajiv I Nijhawan, Shari Ochoa, Edit B Olasz, Elaine Otchere, Clark Otley, Jeremy Oulton, Parth H Patel, Vishal Anil Patel, Arpan V Prabhu, Melissa Pugliano-Mauro, Chrysalyne D Schmults, Sarah Schram, Allen F Shih, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer A Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, Peggy Wu, Nicholas Zajdel, Daniel Zelac, Sarah T Arron
Importance: Skin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTRs), no study has estimated the posttransplant population-based incidence in the United States. Objective: To determine the incidence and evaluate the risk factors for posttransplant skin cancer, including squamous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs receiving a primary organ transplant in 2003 or 2008...
January 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28089997/the-impact-of-age-and-sex-on-in-hospital-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention
#8
Aris Karatasakis, Rahel Iwnetu, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, David E Kandzari, Nicholas J Lembo, Mitul Patel, Ehtisham Mahmud, William L Lombardi, R Michael Wyman, J Aaron Grantham, Anthony H Doing, Catalin Toma, James W Choi, Barry F Uretsky, Jeffrey W Moses, Ajay J Kirtane, Ziad A Ali, Manish Parikh, Judit Karacsonyi, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the effect of age and sex on procedural outcomes and efficiency of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1675 CTO-PCIs performed in 1644 patients between 2012 and 2016 at 15 United States centers. RESULTS: Mean age was 65.3 ± 10 years and 1408 (86%) were men. Overall technical and procedural success rates were 88% and 87%, respectively...
January 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28088548/soil-carbon-dioxide-emissions-from-a-rubber-plantation-on-tropical-peat
#9
Nur Wakhid, Takashi Hirano, Yosuke Okimoto, Siti Nurzakiah, Dedi Nursyamsi
Land-use change in tropical peatland potentially results in a large amount of carbon dioxide (CO2) emissions owing to drainage, which lowers groundwater level (GWL) and consequently enhances oxidative peat decomposition. However, field information on carbon balance is lacking for rubber plantations, which are expanding into Indonesia's peatlands. To assess soil CO2 emissions from an eight-year-old rubber plantation established on peat after compaction, soil CO2 efflux was measured monthly using a closed chamber system from December 2014 to December 2015, in which a strong El Niño event occurred, and consequently GWL lowered deeply...
January 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27984592/inferring-aggregated-functional-traits-from-metagenomic-data-using-constrained-non-negative-matrix-factorization-application-to-fiber-degradation-in-the-human-gut-microbiota
#10
Sébastien Raguideau, Sandra Plancade, Nicolas Pons, Marion Leclerc, Béatrice Laroche
Whole Genome Shotgun (WGS) metagenomics is increasingly used to study the structure and functions of complex microbial ecosystems, both from the taxonomic and functional point of view. Gene inventories of otherwise uncultured microbial communities make the direct functional profiling of microbial communities possible. The concept of community aggregated trait has been adapted from environmental and plant functional ecology to the framework of microbial ecology. Community aggregated traits are quantified from WGS data by computing the abundance of relevant marker genes...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27912868/correlation-between-total-solar-irradiance-and-glycated-hemoglobin-2-to-3-months-later-in-patients-with-diabetes-a-big-data-analysis
#11
Shigesumi Kinchiku, Kazuhiko Kotani, Yukiko Maruguchi, Anna Aikou, Hitoshi Uenomachi, Shouko Kajiya
OBJECTIVES: Much attention has been paid recently to a relationship between glucose metabolism and weather. This study investigated the temporal correlation between total solar irradiance (TSI) and glycated hemoglobin (A1C) values in patients with diabetes. METHODS: In 1531 patients with diabetes who received follow-up care between 2009 and 2013 (type 1 diabetes, 123 patients; type 2 diabetes, 1408 patients; male 53.6%; mean age, 61.2 years), A1C levels were measured a total of 58,830 times...
December 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27904428/a-cross-sectional-anthropometric-study-of-cranial-capacity-among-ukwuani-people-of-south-nigeria
#12
Dennis Erhisenebe Eboh, Ewaen Churchill Okoro, Kingsley Afoke Iteire
BACKGROUND: Cranial capacity is used as a measure of brain volume and has a relationship with age and gender. The purpose of this study was to provide normative data and population-, age- and gender-specific regression formulae related to cranial capacity using head dimensions among the Ukwuani people of Nigeria. METHODS: This study included 605 subjects grouped according to age as follows: 6-12 years, 13-19 years and ≥20 years. A cross-sectional study design using multistage sampling technique was adopted...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27867879/relationship-of-lean-mass-and-obesity-in-indian-urban-children-and-adolescents
#13
M K Garg, Raman K Marwaha, Namita Mahalle, Nikhil Tandon
BACKGROUND: The association of obesity and lean mass (LM) has not been examined well in children and adolescents, and it remains controversial. OBJECTIVE: The objective of this study was to evaluate the relationship of body mass index (BMI) categories and regional obesity with total and regional LM in children and adolescents. METHODS: A total of 1408 children and adolescents (boys 58.9%; girls 41.1%) divided according to BMI (normal weight 79...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27861232/safety-and-efficacy-of-magnetic-resonance-guided-vacuum-assisted-large-volume-breast-biopsy-mr-guided-valb
#14
Simone Schrading, Kevin Strobel, Annika Keulers, Timm Dirrichs, Christiane K Kuhl
OBJECTIVE: Magnetic resonance (MR)-guided vacuum-biopsy is technically demanding and may fail depending on target-lesion size or breast size, and location of lesions within the breast. We developed an MR-guided vacuum-assisted biopsy protocol that collects larger amounts of tissue, aiming at an at least partial or complete ablation of the target-lesion, just as it is intended during surgical (excisional) biopsy. Rationale is to avoid biopsy failures (false-negative results due to undersampling) by collecting larger amounts of tissue...
March 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27853039/pharmacoeconomic-evaluation-of-diabetic-nephropathic-patients-attending-nephrology-department-in-a-tertiary-care-hospital
#15
J V Jose, M Jose, P Devi, R Satish
AIMS: To evaluate the cost of pharmacotherapy and its determinants in diabetic nephropathy (DN) in the nephrology department of a tertiary care hospital. MATERIALS AND METHODS: A prospective observational study was conducted among adult patients visiting nephrology outpatient department (February-July 2015). Data on demography, investigations, and medications prescribed, direct cost and indirect costs were analyzed. We used Chi-squared test for categorical variables and multivariate linear regression analysis to identify determinants of cost of pharmacotherapy and total cost...
November 16, 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27851044/1408-genetic-variants-associated-with-hyperinflammation-in-septic-shock
#16
Kate Kernan, Lina Ghaloul-Gonzalez, Rahil Sethi, Uma Chandran, Janette Lamb, John Kellum, Derek Angus, Joseph Carcillo
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27832553/pharmacological-agents-for-reducing-the-haemodynamic-response-to-tracheal-intubation-in-paediatric-patients-a-systematic-review
#17
M Nazir, B Salim, F A Khan
The primary aim of this review was to assess the effect of pharmacological agents administered to attenuate the haemodynamic response to tracheal intubation in paediatric patients up to 16 years of age undergoing elective surgery. Secondary aims were to identify adverse effects related to these agents, and the agents' roles in decreasing arrhythmias. A systematic search was conducted for articles listed in PubMed, CINAHL or the Cochrane database between January 1980 and June 2014. We included randomised controlled trials where the stated aim of the study included observing the effects of pharmacological agents on the haemodynamic response to tracheal intubation...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27815010/determinants-of-major-league-baseball-pitchers-career-length
#18
Rich Hardy, Tiwaloluwa Ajibewa, Ray Bowman, Jefferson C Brand
PURPOSE: To investigate variables (injury, position, performance, and pitching volume) that affect the career longevity of Major League Baseball pitchers. METHODS: To be eligible, pitchers must have entered Major League Baseball between 1989 and 1992 without missing information for the variables on the website http://www.baseball-reference.com. The variables assessed were average innings pitched per year before and after age 25 years, earned run average, walks and hits divided by innings pitched, strikeout to walk ratio, pitching position, time on the disabled list, length of career, and starting and retirement age...
February 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27683109/pseudoexons-provide-a-mechanism-for-allele-specific-expression-of-apc-in-familial-adenomatous-polyposis
#19
Taina T Nieminen, Walter Pavicic, Noora Porkka, Matti Kankainen, Heikki J Järvinen, Anna Lepistö, Päivi Peltomäki
Allele-specific expression (ASE) of the Adenomatous Polyposis Coli (APC) gene occurs in up to one-third of families with adenomatous polyposis (FAP) that have screened mutation-negative by conventional techniques. To advance our understanding of the genomic basis of this phenomenon, 54 APC mutation-negative families (21 with classical FAP and 33 with attenuated FAP, AFAP) were investigated. We focused on four families with validated ASE and scrutinized these families by sequencing of the blood transcriptomes (RNA-seq) and genomes (WGS)...
September 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27593360/antimicrobial-susceptibility-monitoring-of-dermatological-bacterial-pathogens-isolated-from-diseased-dogs-and-cats-across-europe-compath-results
#20
C Ludwig, A de Jong, H Moyaert, F El Garch, R Janes, U Klein, I Morrissey, J Thiry, M Youala
AIMS: The ComPath project is a pan-European programme dedicated to the monitoring of antimicrobial susceptibility of pathogens from diseased dogs and cats using standardized methods and centralized minimum inhibitory concentration (MIC) determination. Here, the susceptibility of major pathogens is reported from antimicrobial nontreated animals with acute clinical signs of skin, wound or ear infections in 2008-2010. METHODS AND RESULTS: MICs were determined by agar dilution for commonly used antibiotics and interpreted using CLSI breakpoints, if available...
November 2016: Journal of Applied Microbiology
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