Shiva Borzouei, Vida Sheikh, Morteza Ghasemi, Alireza Zamani, Zahra Telikani, Zohre Zareighane, Iraj Salehi, Azadeh Mozayanimonfared, Mohammad Ali Amirzargar, Mahdi Alahgholi-Hajibehzad
Studies indicated that imbalance of proinflammatory and anti-inflammatory cytokines may contribute to development of type 2 diabetes mellitus (T2DM). We hypothesized that sitagliptin and VitD3 may exert more anti-inflammatory effects on the regulation of cytokine balance in T2DM. Nonnephropathic and nephropathic T2DM patients were divided into the subgroups, based on treatments. The effect of 8 months sitagliptin, alone or together with 2 months of VitD3, on serum IFN-γ, IL-4, IL-17, IL-6, IL-21, TGF-β, and IL-37 levels was determined using enzyme-linked immunosorbent assay...
March 11, 2019: Journal of Interferon & Cytokine Research