keyword
MENU ▼
Read by QxMD icon Read
search

Diabetic nephropath

keyword
https://www.readbyqxmd.com/read/29142574/frequency-of-type-2-diabetes-mellitus-in-nephropathic-patients-and-comparison-of-mean-magnesium-levels-in-nephropathic-patients-with-and-without-type-2-diabetes-mellitus
#1
Mariam Azeem, Adil Iqbal, Nasir Farooq Butt, Fawad Ahmad Randhawa, Uzma Malik
Objective: The objective of this study was to determine the frequency of Type 2 diabetes mellitus (T2DM) in patients with nephropathy (i.e. Chronic Kidney Disease Stage 1 to 3) and to compare the mean magnesium levels in diabetic nephropathic patients and non-diabetic nephropathic patients. Methods: This cross-sectional study was conducted in department of Medicine, Mayo Hospital Lahore from August 2014 to February 2015. Using non-probability purposive sampling 200 nephropathic (Chronic Kidney Disease Stage 1 to 3) patients were selected...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28767064/psoralea-corylifolia-l-seed-extract-attenuates-diabetic-nephropathy-by-inhibiting-renal-fibrosis-and-apoptosis-in-streptozotocin-induced-diabetic-mice
#2
Eunhui Seo, Hwansu Kang, Yoon Sin Oh, Hee-Sook Jun
The Psoralea corylifolia L. seed (PCS) is a widely used herbal medicine, but its possible effect against diabetic nephropathy has not been studied. To investigate the anti-nephropathic effect of PCS extracts, we performed experiments using a diabetic mouse model and high glucose-treated mesangial cells. Streptozotocin (STZ)-induced diabetic mice were orally administered PCS extract for 8 weeks (500 mg/kg/day). Increased creatinine clearance, urine volume, urine microalbumin, and mesangial expansion were observed in STZ-induced diabetic mice; these were significantly reduced by PCS extract administration...
August 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28600485/silencing-of-trb3-ameliorates-diabetic-tubule-interstitial-nephropathy-via-pi3k-akt-signaling-in-rats
#3
Yali Ma, Fang Chen, Suxia Yang, Yurui Duan, Zhiqiang Sun, Jun Shi
BACKGROUND Nephropathy, a chronic progressive kidney disease often characterized by glomeruli scarring and sclerosis, is a major complication of diabetes mellitus. Development of nephropathologic lesions has been shown to be associated with suppressed AKT phosphorylation and elevated level of apoptosis. Moreover, it has been established that the TRB3 gene is capable of inhibiting AKT phosphorylation and promoting apoptosis. MATERIAL AND METHODS In this study, we injected TRB3 siRNA into Wistar rats with type 1 diabetes, and monitored development of nephropathy in the rats...
June 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28554309/serum-levels-of-vaspin-and-its-correlation-with-nitric-oxide-in-type-2-diabetic-patients-with-nephropathy
#4
Aynaz Mihanfar, Mohammad Rahmati-Yamchi, Ali Mota, Sima Abediazar, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami
BACKGROUND: Diabetic nephropathy (DN), a serious and prevalent complication of diabetes, has been rapidly raising worldwide. Vaspin, as an adipokine with anti-diabetic effects, is predominantly released from visceral adipose tissue. Moreover, vaspin has the stimulatory effect on nitric oxide (NO) bioavailability through the activation of NO synthase. OBJECTIVE: The aim of the present study was to investigate serum levels of vaspin and their correlation with NO metabolite in diabetic patients with normal renal function and renal insufficiency...
May 29, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28447736/investigation-of-hypoglycemic-hypolipidemic-and-anti%C3%A2-nephritic-activities-of-paecilomyces-tenuipesn45-in-diet-streptozotocin%C3%A2-induced-diabetic-rats
#5
Chungang Liu, Xuerui Zeng, Yi Li, Hongli Ma, Jingjing Song, Yuhuan Li, Yulin Zhou, Robert J Lee, Di Wang
Due to its pharmacological activities, Paecilomyces tenuipes has previously been used as a folk medicine in Asia. The primary aim of the present study was to investigate the hypoglycemic, hypolipidemic and anti‑nephritic effects of P. tenuipes N45 aqueous extracts (PTNE) in a high fat diet/streptozotocin‑induced diabetic rat model. The rats were treated with 120 mg/kg of metformin or 0.04, 0.2 or 1.0 g/kg PTNE for 4 weeks. The hypoglycemic activity of PTNE was confirmed by the observation of reduced fasting blood glucose level and by partially normalized oral glucose tolerance...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28279626/maternal-foetal-outcomes-in-pregnant-women-with-glomerulonephritides-are-all-glomerulonephritides-alike-in-pregnancy
#6
Giorgina Barbara Piccoli, Rossella Attini, Gianfranca Cabiddu, Isabelle Kooij, Federica Fassio, Martina Gerbino, Stefania Maxia, Marilisa Biolcati, Elisabetta Versino, Tullia Todros
In spite of the interest for chronic renal diseases (CKD) in pregnancy data on specific diseases is fragmentary; while recent studies analysed the most common glomerulonephritides (GN), none was addressed at GN as a group. The aim of our study was to analyse the main pregnancy-related outcomes in GN patients in a large multicentre cohort. Patients with a diagnosis of GN were selected from the TOCOS cohort (TOCOS: TOrino Cagliari Observational Study): out of 714 singleton deliveries GN was the diagnosis in 126; lupus GN and IgA nephropathy accounted for 37 and 33 cases; 1418 low-risk singleton deliveries followed-up in the same Centers served as controls (non diabetic, non nephropathic, non obese women, without any other known chronic illness; pregnancies after ovodonation or in vitro fertilisation were excluded, if declared)...
May 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28276300/value-of-renal-biopsy-in-diagnosing-infantile-nephropathic-cystinosis-associated-with-secondary-nephrogenic-diabetes-insipidus
#7
Emily Joyce, Jacqueline Ho, Areeg El-Gharbawy, Cláudia M Salgado, Sarangarajan Ranganathan, Miguel Reyes-Múgica
Cystinosis is the most common cause of inherited renal Fanconi syndrome in young children, and typically presents with laboratory findings of a proximal tubulopathy and corneal crystals by one year of age. We describe here renal biopsy findings in a 20-month-old patient with an atypical presentation of distal renal tubular acidosis, diabetes insipidus, and the absence of corneal crystals. Although renal biopsy is usually not necessary to establish the diagnosis of cystinosis, when the patient presents with atypical signs and symptoms, a renal biopsy may be extremely valuable...
January 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/27891460/assessment-and-correlation-of-urea-and-creatinine-levels-in-saliva-and-serum-of-patients-with-chronic-kidney-disease-diabetes-and-hypertension-a-research-study
#8
Divya Pandya, Anil Kumar Nagrajappa, K S Ravi
INTRODUCTION: Serum urea and creatinine are most widely accepted parameters to assess Chronic Kidney Disease (CKD)status as well as to assess renal status in susceptible diabetic and hypertensive subjects. AIM: To assess and correlate the serum and salivary urea and creatinine levels of CKD, diabetes mellitus and hypertensive subjects. MATERIALS AND METHODS: This cross-sectional study was done on 120 subjects involving 30 CKD, 30 diabetic, 30 hypertensive subjects and 30 healthy controls...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27853039/pharmacoeconomic-evaluation-of-diabetic-nephropathic-patients-attending-nephrology-department-in-a-tertiary-care-hospital
#9
J V Jose, M Jose, P Devi, R Satish
AIMS: To evaluate the cost of pharmacotherapy and its determinants in diabetic nephropathy (DN) in the nephrology department of a tertiary care hospital. MATERIALS AND METHODS: A prospective observational study was conducted among adult patients visiting nephrology outpatient department (February-July 2015). Data on demography, investigations, and medications prescribed, direct cost and indirect costs were analyzed. We used Chi-squared test for categorical variables and multivariate linear regression analysis to identify determinants of cost of pharmacotherapy and total cost...
January 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27777973/systems-biology-analysis-reveals-role-of-mdm2-in-diabetic-nephropathy
#10
Rintaro Saito, Anaïs Rocanin-Arjo, Young-Hyun You, Manjula Darshi, Benjamin Van Espen, Satoshi Miyamoto, Jessica Pham, Minya Pu, Simone Romoli, Loki Natarajan, Wenjun Ju, Matthias Kretzler, Robert Nelson, Keiichiro Ono, Dana Thomasova, Shrikant R Mulay, Trey Ideker, Vivette D'Agati, Ergin Beyret, Juan Carlos Izpisua Belmonte, Hans Joachim Anders, Kumar Sharma
To derive new insights in diabetic complications, we integrated publicly available human protein-protein interaction (PPI) networks with global metabolic networks using metabolomic data from patients with diabetic nephropathy. We focused on the participating proteins in the network that were computationally predicted to connect the urine metabolites. MDM2 had the highest significant number of PPI connections. As validation, significant downregulation of MDM2 gene expression was found in both glomerular and tubulointerstitial compartments of kidney biopsy tissue from 2 independent cohorts of patients with diabetic nephropathy...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27765534/diabetic-nephropathy-and-endothelial-dysfunction-current-and-future-therapies-and-emerging-of-vascular-imaging-for-preclinical-renal-kinetic-study
#11
REVIEW
Wilson Kc Leung, L Gao, Parco M Siu, Christopher Wk Lai
An explosion in global epidemic of type 2 diabetes mellitus poses major rise in cases with vascular endothelial dysfunction ranging from micro- (retinopathy, nephropathy and neuropathy) to macro-vascular (atherosclerosis and cardiomyopathy) conditions. Functional destruction of endothelium is regarded as an early event that lays the groundwork for the development of renal microangiopathy and subsequent clinical manifestation of nephropathic symptoms. Recent research has shed some light on the molecular mechanisms of type 2 diabetes-associated comorbidity of endothelial dysfunction and nephropathy...
December 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/27663212/comparison-of-serum-levels-of-il-18-in-peripheral-blood-of-patients-with-type-ii-diabetes-with-nephropathy-clinical-protests-and-patients-with-type-ii-diabetes-without-nephropathy-clinical-protests
#12
M Mir, A Rostami, M Hormozi
BACKGROUND AND AIM: Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardiovascular diseases. This study aimed to test the hypothesis that the serum level of IL-18 is a common predictor of nephropathy and atherosclerosis in patients with type 2 diabetes...
October 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27536690/autophagy-in-chronic-kidney-diseases
#13
REVIEW
Na Liu, Yingfeng Shi, Shougang Zhuang
BACKGROUND: Autophagy is the degrading process of protein and organelles mediated by lysosomes. This process is involved in purging senescent organelles and subversive proteins while maintaining the stability of the intracellular environment. This phenomenon is highly conservative, existing in nearly every species, and is involved in cell growth, proliferation and tumorigenesis. SUMMARY: In recent decades, with the discovery of autophagy-related genes and proteins in conjunction with the improvement in detection methods, the study of autophagy is constantly achieving new breakthroughs...
April 2016: Kidney Diseases
https://www.readbyqxmd.com/read/27399115/urinary-n-acetyl-%C3%AE-d-glucosaminidase-an-early-marker-of-diabetic-kidney-disease-might-reflect-glucose-excursion-in-patients-with-type-2-diabetes
#14
COMPARATIVE STUDY
So Ra Kim, Yong-Ho Lee, Sang-Guk Lee, Eun Seok Kang, Bong-Soo Cha, Jeong-Ho Kim, Byung-Wan Lee
Recently, several renal tubular damage markers have gained considerable attention because of their clinical implications as sensitive and specific biomarkers for early stage diabetic kidney disease. However, little is known about the demographic and glucometabolic factors affecting levels of urinary N-acetyl-β-D-glucosaminidase (NAG), a marker of proximal tubular damage, in type 2 diabetes mellitus (T2DM).The aim of this study was to investigate the clinical relevance of urinary NAG with regard to demographic and glucometabolic parameters, as well as nephropathic parameters, by comparing the glomerulopathic marker of albuminuria...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26816588/role-of-alteration-in-treg-th17-cells-balance-in-nephropathic-patients-with-type-2-diabetes-mellitus
#15
Sameh Abouzeid, Nevine Sherif
INTRODUCTION: In type 2 diabetes mellitus, the adaptive immune system drives systemic inflammation, promoting insulin resistance and related complications, such as diabetic nephropathy. Increased infiltration of activated T lymphocytes has been found in patients with diabetic nephropathy. T-cell influx and accumulation are the factors that aggravate diabetic nephropathy and link with glomerular filtration surface and albumin excretion. An appropriate balance between pro-inflammatory (T helper 17: Th17, and T helper 1: Th1) and anti-inflammatory (regulatory T cells: Tregs) subsets of T cells is critical to maintain homeostasis and avoid inflammatory disease...
December 2015: Electronic Physician
https://www.readbyqxmd.com/read/26812958/dysmorphic-erythrocytes-are-superior-to-hematuria-for-indicating-non-diabetic-renal-disease-in-type%C3%A2-2-diabetics
#16
Zhe-yi Dong, Yuan-da Wang, Qiang Qiu, Kai Hou, Li Zhang, Jie Wu, Han-yu Zhu, Guang-yan Cai, Xue-feng Sun, Xue-guang Zhang, Mo-yan Liu, Jia Kou, Xiang-mei Chen
AIMS/INTRODUCTION: There are sparse and limited studies on erythrocyte morphology in renal biopsy identifying nephropathic patients among type 2 diabetics. The present study sought to clarify the predictive value of dysmorphic erythrocytes in type 2 diabetics with non-diabetic renal disease and influences on hematuria. MATERIALS AND METHODS: We examined 198 patients with type 2 diabetes who underwent kidney biopsies between 2012 and 2013. Hematuria was defined as >3 or >10 red blood cells per high-power field (RBCs/hpf) in urine sediment...
January 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/26718133/anti-diabetic-activities-of-paecilomyces-tenuipes-n45-extract-in-alloxan-induced-diabetic-mice
#17
Linna Du, Chungang Liu, Meiyu Teng, Qingfan Meng, Jiahui Lu, Yulin Zhou, Yan Liu, Yingkun Cheng, Di Wang, Lesheng Teng
Due to the limitations of existing anti-diabetic drugs, the treatment of diabetes mellitus remains a significant challenge. The present study aimed to investigate the hypoglycemic, hypolipidemic and antioxidant effects of Paecilomyces tenuipes N45 extracts on alloxan-induced type I diabetes mellitus in mice. Diabetic Kunming mice were orally administered with water extract (WE) at doses of 2.50, 0.25 and 0.05 g/kg) or alcohol extract (AE) at doses of 2.00, 0.20 and 0.04 g/kg, for 3 weeks, following which the levels of factors associated with blood glucose, lipids and free radicals were determined...
February 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26580242/the-value-of-renal-biopsy-in-diagnosing-infantile-nephropathic-cystinosis-associated-with-secondary-nephrogenic-diabetes-insipidus
#18
Emily Joyce, Jacqueline Ho, Areeg El-Gharbawy, Cláudia M Salgado, Sarangarajan Ranganathan, Miguel Reyes-Múgica
Cystinosis is a rare autosomal recessive disorder and the most common cause of inherited renal Fanconi syndrome in young children. Renal biopsy is usually not necessary to establish the diagnosis, but when the patient presents with atypical signs and symptoms, a renal biopsy may be extremely valuable. We describe here renal biopsy findings in a patient with cystinosis. A 20-month-old male presented with failure to thrive, polyuria, polydipsia and rickets. He initially showed evidence of a renal tubular acidosis, mild renal insufficiency and nephrogenic diabetes insipidus...
November 18, 2015: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/26428531/does-glimepiride-alter-the-pharmacokinetics-of-sildenafil-citrate-in-diabetic-nephropathy-animals-investigating-mechanism-of-interaction-by-molecular-modeling-studies
#19
Alok Shiomurti Tripathi, Ajay Kumar Timiri, Papiya Mitra Mazumder, Anil Chandewar
The present study evaluates possible drug interactions between glimepiride (GLIM) and sildenafil citrate (SIL) in streptozotocin (STZ)-induced diabetic nephropathic (DN) animals and also postulates the possible mechanism of interaction based on molecular modeling studies. Diabetic nephropathy was induced by single dose of STZ (60 mg kg(-1), i.p.) and was confirmed by assessing blood and urine biochemical parameters 28 days after induction. Selected DN animals were used to explore the drug interaction between GLIM (0...
October 2015: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/26295204/sildenafil-a-phosphodiesterase-type-5-inhibitor-attenuates-diabetic-nephropathy-in-stz-induced-diabetic-rats
#20
COMPARATIVE STUDY
Alok Shiomurti Tripathi, Papiya Mitra Mazumder, Anil Vilasrao Chandewar
BACKGROUND: The present study evaluates the possible mechanism of sildenafil citrate (SIL) for the attenuation of renal failure in diabetic nephropathic (DN) animals. METHODS: Diabetic nephropathy was induced by a single dose of streptozotocin (STZ) (60 mg/kg, i.p.) and confirmed by assessing the blood and urine biochemical parameters on the 28th day of its induction. The selected DN animals were treated with glimepiride (0.5 mg/kg, p.o.) and SIL (2.5 mg/kg, p.o...
January 2016: Journal of Basic and Clinical Physiology and Pharmacology
keyword
keyword
99016
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"