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https://www.readbyqxmd.com/read/29765549/deregulation-of-methylation-of-transcribed-ultra-conserved-regions-in-colorectal-cancer-and-their-value-for-detection-of-adenomas-and-adenocarcinomas
#1
Anastasia E Kottorou, Anna G Antonacopoulou, Foteinos-Ioannis D Dimitrakopoulos, Georgia Diamantopoulou, Chaido Sirinian, Melpomeni Kalofonou, Theodoros Theodorakopoulos, Chrysa Oikonomou, Evangelos C Katsakoulis, Angelos Koutras, Thomas Makatsoris, Nikos Demopoulos, Georgia Stephanou, Michalis Stavropoulos, Konstantinos C Thomopoulos, Haralabos P Kalofonos
Expression of Transcribed Ultraconserved Regions (T-UCRs) is often deregulated in cancer. The present study assesses the expression and methylation of three T-UCRs (Uc160, Uc283 and Uc346) in colorectal cancer (CRC) and explores the potential of T-UCR methylation in circulating DNA for the detection of adenomas and adenocarcinomas. Expression levels of Uc160, Uc283 and Uc346 were lower in neoplastic tissues from 64 CRC patients (statistically significant for Uc160, p <0.001), compared to non-malignant tissues, while methylation levels displayed the inverse pattern ( p <0...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29581345/ischemic-stroke-alters-the-expression-of-the-transcribed-ultraconserved-regions-of-the-genome-in-rat-brain
#2
Suresh L Mehta, Raghu Vemuganti
BACKGROUND AND PURPOSE: Human and rodent genomes diverged ≈75 million years ago. However, 481 regions of their genomes (200-779 nucleotide each) remained absolutely conserved and form noncoding RNAs known as transcribed ultraconserved regions (T-UCRs). The functional significance of T-UCRs is not apparent, but their altered expression is associated with many diseases, and thus thought to be critical for life. We presently investigated the poststroke temporal changes in the expression of T-UCRs with potential functional significance...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29494516/the-unforeseen-non-coding-rnas-in-head-and-neck-cancer
#3
REVIEW
Alexandra Iulia Irimie, Alina-Andreea Zimta, Cristina Ciocan, Nikolay Mehterov, Diana Dudea, Cornelia Braicu, Ioana Berindan-Neagoe
Previously ignored non-coding RNAs (ncRNAs) have become the subject of many studies. However, there is an imbalance in the amount of consideration that ncRNAs are receiving. Some transcripts such as microRNAs (miRNAs) or small interfering RNAs (siRNAs) have gained much attention, but it is necessary to investigate other "pieces of the RNA puzzle". These can offer a more complete view over normal and pathological cell behavior. The other ncRNA species are less studied, either due to their recent discovery, such as stable intronic sequence RNA (sisRNA), YRNA, miRNA-offset RNAs (moRNA), telomerase RNA component (TERC), natural antisense transcript (NAT), transcribed ultraconserved regions (T-UCR), and pseudogene transcript, or because they are still largely seen as non-coding transcripts with no relevance to pathogenesis...
March 1, 2018: Genes
https://www.readbyqxmd.com/read/29425744/lncrna-uc-173-is-a-key-molecule-for-the-regulation-of-lead-induced-renal-tubular-epithelial-cell-apoptosis
#4
Jiabi Qin, Huacheng Ning, Yao Zhou, Yue Hu, Bo Huang, Yue Wu, Ruixue Huang
Transcribed ultra-conserved region (T-UCR) transcripts are a novel class of long non-coding RNAs (lncRNAs) transcribed from ultra-conserved region which is highly conserved in human, rat, and mouse genome. LncRNA UC.173 has been found significantly down-regulated in lead-exposed population and lead-exposed animal mode, and had an inhibitory effect on lead-induced nerve cell apoptosis. We supposed that lncRNA UC.173 had an inhibitory effect on lead-induced renal tubular epithelial cell apoptosis. Thus, the aim of our study was to explore the function of lncRNA UC...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29212226/transcribed-ultraconserved-region-uc-63-promotes-resistance-to-docetaxel-through-regulation-of-androgen-receptor-signaling-in-prostate-cancer
#5
Yohei Sekino, Naoya Sakamoto, Keisuke Goto, Ririno Honma, Yoshinori Shigematsu, Kazuhiro Sentani, Naohide Oue, Jun Teishima, Akio Matsubara, Wataru Yasui
Docetaxel is the standard chemotherapy for metastatic castration-resistant prostate cancer (CRPC). However, nearly all patients ultimately become refractory due to the development of docetaxel resistance. The transcribed ultraconserved regions (T-UCRs) are a novel class of non-coding RNAs that are absolutely conserved across species and are involved in carcinogenesis including prostate cancer (PC). In this study, we investigated the transcriptional levels of 26 representative T-UCRs and determined the regions that were differentially expressed in PC...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29180617/transcribed-ultraconserved-region-339-promotes-carcinogenesis-by-modulating-tumor-suppressor-micrornas
#6
Ivan Vannini, Petra M Wise, Kishore B Challagundla, Meropi Plousiou, Mirco Raffini, Erika Bandini, Francesca Fanini, Giorgia Paliaga, Melissa Crawford, Manuela Ferracin, Cristina Ivan, Linda Fabris, Ramana V Davuluri, Zhiyi Guo, Maria Angelica Cortez, Xinna Zhang, Lu Chen, Shuxing Zhang, Cecilia Fernandez-Cymering, Leng Han, Silvia Carloni, Samanta Salvi, Hui Ling, Mariam Murtadha, Paolo Neviani, Barbara J Gitlitz, Ite A Laird-Offringa, Patrick Nana-Sinkam, Massimo Negrini, Han Liang, Dino Amadori, Amelia Cimmino, George A Calin, Muller Fabbri
The transcribed ultraconserved regions (T-UCRs) encode long non-coding RNAs implicated in human carcinogenesis. Their mechanisms of action and the factors regulating their expression in cancers are poorly understood. Here we show that high expression of uc.339 correlates with lower survival in 210 non-small cell lung cancer (NSCLC) patients. We provide evidence from cell lines and primary samples that TP53 directly regulates uc.339. We find that transcribed uc.339 is upregulated in archival NSCLC samples, functioning as a decoy RNA for miR-339-3p, -663b-3p, and -95-5p...
November 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29055695/conserved-expression-of-ultra-conserved-noncoding-rna-in-mammalian-nervous-system
#7
Junjie Zhou, Ruiyu Wang, Jing Zhang, Liyuan Zhu, Wei Liu, Shuaiyao Lu, Pan Chen, Hanlu Li, Bin Yin, Jiangang Yuan, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng
T-UCRs, a class of long non-coding RNAs that are transcribed from ultra-conserved regions (UCRs), might play an important role in development and diseases. However, the amount of T-UCRs that are conservatively expressed in the developing nervous systems of mice, monkeys and humans is still unknown. In this study, we screened the RNA sequence signals of 481 identified UCRs in an E14.5 mouse brain from the ENCODE database and found 76 UCRs that may be transcribed into T-UCRs. To verify the expression of these potential T-UCRs, we used an RT-PCR experiment and identified that 60 T-UCRs can be expressed in the E14...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29042220/long-noncoding-rna-uc-173-promotes-renewal-of-the-intestinal-mucosa-by-inducing-degradation-of-microrna-195
#8
Lan Xiao, Jing Wu, Jun-Yao Wang, Hee Kyoung Chung, Sudhakar Kalakonda, Jaladanki N Rao, Myriam Gorospe, Jian-Ying Wang
BACKGROUND AND AIMS: The mammalian intestinal epithelium self-renews rapidly and homeostasis is preserved via tightly controlled mechanisms. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions, but little is known about their role in maintaining the integrity of the intestinal epithelium. We searched for T-UCRs that regulate growth of the intestinal mucosa and investigated the mechanism by which T-UCR uc.173 regulates epithelial renewal...
February 2018: Gastroenterology
https://www.readbyqxmd.com/read/28916343/the-role-of-a-new-class-of-long-noncoding-rnas-transcribed-from-ultraconserved-regions-in-cancer
#9
REVIEW
Daniela Terracciano, Sara Terreri, Filomena de Nigris, Valerio Costa, George A Calin, Amelia Cimmino
Ultraconserved regions (UCRs) represent a relatively new class of non-coding genomic sequences highly conserved between human, rat and mouse genomes. These regions can reside within exons of protein-coding genes, despite the vast majority of them localizes within introns or intergenic regions. Several studies have undoubtedly demonstrated that most of these regions are actively transcribed in normal cells/tissues, where they contribute to regulate many cellular processes. Interestingly, these non-coding RNAs exhibit aberrant expression levels in human cancer cells and their expression profiles have been used as prognostic factors in human malignancies, as well as to unambiguously distinguish among distinct cancer types...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28729024/understanding-the-genomic-ultraconservations-t-ucrs-and-cancer
#10
REVIEW
Linda Fabris, George A Calin
Transcribed ultraconserved regions (T-UCRs) are genomic regions conserved across large evolutionary distances, which encode for noncoding RNAs that serve as regulators of gene expression. Although T-UCRs have been linked to multiple aspects of mammalian gene regulation, the roles of their extreme evolutionary conservation remain largely unexplained. Growing body of literature is now focusing on T-UCRs as potential cancer biomarkers or as new drug targets. Here we present an overview of the discoveries so far published about the role of T-UCR in cancer and disease...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28723685/downregulation-of-macrophage-derived-t-ucr-uc-306-associates-with-poor-prognosis-in-hepatocellular-carcinoma
#11
Hong-Lin Luo, Jie Chen, Tao Luo, Fei-Xiang Wu, Jun-Jie Liu, Hui-Feng Wang, Miao Chen, Le-Qun Li, Hang Li
BACKGROUND/AIMS: Increasing evidence suggests that T-UCRs are involved in the development of cancer. In this study, we evaluated the role of a macrophage-derived T-UCR, uc.306, in the prognosis of hepatitis B (HBV)-related hepatocellular carcinoma (HCC). METHODS: The uc.306 was obtained by screening microassay data obtained during the polarization of U937 cells from the M2 to M1 phenotype. Uc.306 and macrophage molecule markers were detected by qPCR. Immunohistochemical (IHC) assays were used to examine the M1/M2 status of 90 paired HCC tissues...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28653781/differential-expression-profile-of-long-non-coding-rna-in-cardiomyocytes-autophagy-induced-by-angiotensin-ii
#12
Ying Gu, Fan Yang, Ru-Ming Xu, Yun-Yan Zhang, Yang Li, Su-Xuan Liu, Guan-Xin Zhang, Guo-Kun Wang, Li-Ping Ma
Autophagy is a ubiquitous intracellular process for cellular homeostasis maintenance by recycling damaged protein and organelles. Dysregulation of cardiomyocytes autophagic activity is implicated in various heart diseases. Recent studies had demonstrated that long non-coding RNAs (lncRNAs) played crucial roles on modulation of autophagic activity. In this study, we first established an angiotensin II-induced autophagy model on neonatal rat cardiomyocytes. Western blot assay confirmed that the expression of Beclin 1 and the conversion of soluble LC3-I to lipid bound LC3-II were significantly increased at 12 h after angiotensin II stimulation, but the cardiomyocytes surface area and hypertrophic markers expression had no significant change...
October 2017: Cell Biology International
https://www.readbyqxmd.com/read/28382457/expression-and-function-of-uc-160-a-transcribed-ultraconserved-region-in-gastric-cancer
#13
Ririno Honma, Keisuke Goto, Naoya Sakamoto, Yohei Sekino, Kazuhiro Sentani, Naohide Oue, Wataru Yasui
BACKGROUND: Transcribed ultraconserved regions (T-UCRs) are a novel class of noncoding RNAs that are highly conserved among the orthologous regions in most vertebrates. It has been reported that T-UCRs have distinct signatures in human cancers. We previously discovered the downregulation of T-UCR expression in gastric cancer (GC), indicating that T-UCRs could play an important role in GC biology. Uc.160+, a T-UCR reported to be downregulated in human cancer, has not been examined in GC...
November 2017: Gastric Cancer
https://www.readbyqxmd.com/read/27986786/novel-lncrna-t-ucr-as-a-potential-downstream-driver-of-the-wnt-%C3%AE-catenin-pathway-in-hepatobiliary-carcinogenesis
#14
COMMENT
Maite G Fernández-Barrena, Maria J Perugorria, Jesus M Banales
No abstract text is available yet for this article.
July 2017: Gut
https://www.readbyqxmd.com/read/27983635/new-cross-talk-layer-between-ultraconserved-non-coding-rnas-micrornas-and-polycomb-protein-yy1-in-bladder-cancer
#15
Sara Terreri, Montano Durso, Vincenza Colonna, Alessandra Romanelli, Daniela Terracciano, Matteo Ferro, Sisto Perdonà, Luigi Castaldo, Ferdinando Febbraio, Filomena de Nigris, Amelia Cimmino
MicroRNAs (miRNAs) are highly conserved elements in mammals, and exert key regulatory functions. Growing evidence shows that miRNAs can interact with another class of non-coding RNAs, so-called transcribed ultraconserved regions (T-UCRs), which take part in transcriptional, post-transcriptional and epigenetic regulation processes. We report here the interaction of miRNAs and T-UCRs as a network modulating the availability of these non-coding RNAs in bladder cancer cells. In our cell system, antagomiR-596 increased the expression of T-UCR 201+...
December 14, 2016: Genes
https://www.readbyqxmd.com/read/27846191/noncoding-transcribed-ultraconserved-region-t-ucr-uc-261-participates-in-intestinal-mucosa-barrier-damage-in-crohn-s-disease
#16
Xiao Xian Qian, Jiang Chen Peng, An Tao Xu, Di Zhao, Yu Qi Qiao, Tian Rong Wang, Jun Shen, Zhi Hua Ran
BACKGROUND: To date, 481 ultraconserved regions (UCRs) have been discovered in human genome. We aimed to investigate the transcribed UCR (T-UCR) characteristics in Crohn's disease (CD ) and determine whether T-UCR uc.261 participated in intestinal mucosa barrier damage. METHODS: T-UCRs were screened in active CD mucosa using the Arraystar Human T-UCR Microarray and validated with quantitative real-time reverse transcription PCR, together with tight junction proteins (TJPs) including junctional adhesion molecule-A, occludin, claudin-1, and zonula occluden-1...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27618837/wnt-signalling-modulates-transcribed-ultraconserved-regions-in-hepatobiliary-cancers
#17
Pietro Carotenuto, Matteo Fassan, Rosantony Pandolfo, Andrea Lampis, Caterina Vicentini, Luciano Cascione, Viola Paulus-Hock, Luke Boulter, Rachel Guest, Luca Quagliata, Jens Claus Hahne, Rachel Ridgway, Tam Jamieson, Dimitris Athineos, Angelo Veronese, Rosa Visone, Claudio Murgia, Giulia Ferrari, Vincenza Guzzardo, Thomas Ronald Jeffry Evans, Martin MacLeod, Gui Ji Feng, Trevor Dale, Massimo Negrini, Stuart J Forbes, Luigi Terracciano, Aldo Scarpa, Tushar Patel, Nicola Valeri, Paul Workman, Owen Sansom, Chiara Braconi
OBJECTIVE: Transcribed-ultraconserved regions (T-UCR) are long non-coding RNAs which are conserved across species and are involved in carcinogenesis. We studied T-UCRs downstream of the Wnt/β-catenin pathway in liver cancer. DESIGN: Hypomorphic Apc mice ( Apcfl/fl ) and thiocetamide (TAA)-treated rats developed Wnt/β-catenin dependent hepatocarcinoma (HCC) and cholangiocarcinoma (CCA), respectively. T-UCR expression was assessed by microarray, real-time PCR and in situ hybridisation...
July 2017: Gut
https://www.readbyqxmd.com/read/27500182/altered-t-ucrs-expression-profile-in-the-spinal-cord-of-mice-with-neuropathic-pain
#18
Bao-Chun Jiang, Tian Yang, Li-Na He, Yuan-Xiang Tao, Yong-Jing Gao
Spinal cord plays an important role in the transmission and modulation of nociceptive information. Global changes in gene expression in the spinal cord contribute to the induction and maintenance of neuropathic pain. Transcribed Ultraconserved Regions (T-UCRs), a novel class of long noncoding RNAs, can regulate gene expression at both transcriptional and post-transcriptional levels and are related to many human diseases such as cancer, Alzheimer's disease, and heart diseases. In this study, we screened abnormal T-UCRs expression in the spinal cord under spinal nerve ligation (SNL)-induced neuropathic pain condition...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27447964/ultraconserved-long-non-coding-rna-uc-63-in-breast-cancer
#19
Alberto Marini, Anna Maria Lena, Emanuele Panatta, Cristina Ivan, Leng Han, Han Liang, Margherita Annicchiarico-Petruzzelli, Nicola Di Daniele, George A Calin, Eleonora Candi, Gerry Melino
Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/27363020/globally-increased-ultraconserved-noncoding-rna-expression-in-pancreatic-adenocarcinoma
#20
Jinmai Jiang, Ana Clara P Azevedo-Pouly, Roxana S Redis, Eun Joo Lee, Yuriy Gusev, David Allard, Dhruvitkumar S Sutaria, Mohamed Badawi, Ola A Elgamal, Megan R Lerner, Daniel J Brackett, George A Calin, Thomas D Schmittgen
Transcribed ultraconserved regions (T-UCRs) are a class of non-coding RNAs with 100% sequence conservation among human, rat and mouse genomes. T-UCRs are differentially expressed in several cancers, however their expression in pancreatic adenocarcinoma (PDAC) has not been studied. We used a qPCR array to profile all 481 T-UCRs in pancreatic cancer specimens, pancreatic cancer cell lines, during experimental pancreatic desmoplasia and in the pancreases of P48Cre/wt; KrasLSL-G12D/wt mice. Fourteen, 57 and 29% of the detectable T-UCRs were differentially expressed in the cell lines, human tumors and transgenic mouse pancreases, respectively...
August 16, 2016: Oncotarget
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