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Chlamydia and cervix cancer

Denise Wohlmeister, Débora Renz Barreto Vianna, Virgínia Etges Helfer, Fabrícia Gimenes, Marcia Edilaine Lopes Consolaro, Regina Bones Barcellos, Maria Lucia Rossetti, Luciane Noal Calil, Andréia Buffon, Diogo André Pilger
The influence of different infectious agents and their association with human papillomavirus (HPV) in cervical carcinogenesis have not been completely elucidated. This study describes the association between cytological changes in cervical epithelium and the detection of the most relevant aetiological agents of sexually transmitted diseases. Samples collected from 169 patients were evaluated by conventional cytology followed by molecular analysis to detect HPV DNA, Chlamydia trachomatis, herpes simplex virus 1 and 2,Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, andTreponema pallidum, besides genotyping for most common high-risk HPV...
February 2016: Memórias do Instituto Oswaldo Cruz
Edith Margarita Quinónez-Calvache, Dora Inés Ríos-Chaparro, Juan David Ramírez, Sara Cecilia Soto-De León, Milena Camargo, Luisa Del Río-Ospina, Ricardo Sánchez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
BACKGROUND: Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium, is the commonest infectious bacterial agent of sexual transmission throughout the world. It has been shown that the presence of this bacteria in the cervix represents a risk regarding HPV persistence and, thereafter, in developing cervical cancer (CC). Prevalence rates may vary from 2% to 17% in asymptomatic females, depending on the population being analysed. This study reports the identification of C...
2016: PloS One
Samira Zoa Assoumou, Angelique Ndjoyi Mbiguino, Barthelemy Mabika Mabika, Sidonie Nguizi Ogoula, Mohammed El Mzibri, Abdelkrim Khattabi, My Mustapha Ennaji
BACKGROUND: Cervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Gabon, few studies have been performed to evaluate the prevalence and determinants of HPV infection in this country. The aim of this study was to determine the HPV prevalence and distribution in a population of Gabonese women with normal cytology and cervical abnormalities...
2016: Infectious Agents and Cancer
Em Grueva
UNLABELLED: A short review of the biological and epidemiological established causal role of human papillomavirus (HPV) in all types of cervical cancer most cancers of the vagina and anus of the cancer of the vulva, penis, and oropharynx, as and other types of cancer causally related to HPV such as skin cancer, melanoma and cancers of the conjunctiva exposure of other sexually transmissible infections (STD), such as Chlamydia trachomatis as co-factors that modify risk are required for transfer of cervical HPV infection to cancer...
2014: Akusherstvo i Ginekologii︠a︡
Serena Bellaminutti, Silva Seraceni, Francesco De Seta, Tarik Gheit, Massimo Tommasino, Manola Comar
Chlamydia trachomatis causing chronic inflammatory diseases has investigated as possible human papillomavirus (HPV) cofactor in cervical cancer. The aim of this study is to evaluate the prevalence of Chlamydia trachomatis and HPV co-infection in different cohorts of asymptomatic women from a Northern Italy area at high incidence for cervical cancer. Cervical samples from 441 females were collected from Cervical Cancer Screening Program, Sexually Transmitted Infectious and Assisted Reproductive Technology centres...
November 2014: Journal of Medical Virology
Anthonio Adefuye, Kurt Sales
Cervical cancer is one of the leading gynaecological malignancies worldwide. It is an infectious disease of the cervix, associated with human papillomavirus infection (HPV), infection with bacterial agents such as Chlamydia trachomatis and Neisseria gonorrhoea as well as human immunodeficiency virus (HIV). Furthermore, it is an AIDS-defining disease with an accelerated mortality in HIV-infected women with cervical cancer. With the introduction of robust vaccination strategies against HPV in the developed world, it is anticipated that the incidence of cervical cancer will decrease in the coming years...
2012: Scientifica
Neerja Bhatla, Kriti Puri, Elizabeth Joseph, Alka Kriplani, Venkateswaran K Iyer, V Sreenivas
BACKGROUND & OBJECTIVES: Human papillomavirus (HPV) is the necessary cause of cervical cancer and Chlamydia trachomatis (CT) is considered a potential cofactor in the development of cervical intraepithelial neoplasia (CIN). The objective of this pilot study was to determine the association of CT infection with HPV, other risk factors for cervical cancer, and CIN in symptomatic women. METHODS: A total of 600 consecutively selected women aged 30-74 yr with persistent vaginal discharge, intermenstrual/postcoital bleeding or unhealthy cervix underwent conventional Pap smear, Hybrid Capture 2 (HC2) testing for HPV and CT DNA and colposcopy, with directed biopsy of all lesions...
March 2013: Indian Journal of Medical Research
Andrea E Knowlton, Larry J Fowler, Rahul K Patel, Shannon M Wallet, Scott S Grieshaber
Chlamydia are gram negative, obligate intracellular bacterial organisms with different species causing a multitude of infections in both humans and animals. Chlamydia trachomatis is the causative agent of the sexually transmitted infection (STI) Chlamydia, the most commonly acquired bacterial STI in the United States. Chlamydial infections have also been epidemiologically linked to cervical cancer in women co-infected with the human papillomavirus (HPV). We have previously shown chlamydial infection results in centrosome amplification and multipolar spindle formation leading to chromosomal instability...
2013: PloS One
Taghi Naserpour Farivar, Pouran Johari
BACKGROUND: Cervical cancer is one of the most common cancers in developing countries and the second most common type of cancer in women globally. Several recent studies suggested a co factor role for Chlamydia trachomatis in pathogenesis of cervical cancer. This study aimed to evaluate existence of C. trachomatis DNA in pathologic blocks of patients with cervical cancer. MATERIALS AND METHODS: Seventy-six formaldehyde fixed paraffin embedded tissue specimens from patients with histologically proven history of cervical cancer as well as 150 blocks from healthy peoples were included in the present study...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Agnieszka Mocarska, Elzbieta Starosławska, Iwonna Zelazowska-Cieślińska, Marek Łosicki, Dominika Stasiewicz, Dariusz Kieszko, Franciszek Burdan
Neoplasm of the cervix, especially squamous cell cancer, is one of the most common malignancy of female genital organs. It etiology is complex; however, human papilloma virus (mostly HPV type 18, 16 and 45) infection seems to be the most important one. Other risk factors include: early sexual initiation, multiple pregnancies and labors, concomitant infections (Chlamydia trachomatis, Neisseria gonorrhea, HSV2 - herpes simplex virus) of the genital tract, AIDS, immunosuppressive therapy, smoking and low socioeconomic status...
August 2012: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Edith Roset Bahmanyar, Jorma Paavonen, Paulo Naud, Jorge Salmerón, Song-Nan Chow, Dan Apter, Henry Kitchener, Xavier Castellsagué, Julio C Teixeira, S Rachel Skinner, Unnop Jaisamrarn, Genara A Limson, Suzanne M Garland, Anne Szarewski, Barbara Romanowski, Fred Aoki, Tino F Schwarz, Willy A J Poppe, Newton S De Carvalho, Diane M Harper, F Xavier Bosch, Alice Raillard, Dominique Descamps, Frank Struyf, Matti Lehtinen, Gary Dubin
OBJECTIVE: We evaluated baseline data from the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681) on the association between behavioral risk factors and HPV infection and cervical abnormalities. METHODS: Women completed behavioral questionnaires at baseline. Prevalence of HPV infection and cervical abnormalities (detected by cytological or histological procedures) and association with behavioral risk factors were analyzed by univariate and stepwise multivariable logistic regressions...
December 2012: Gynecologic Oncology
Kurt Jason Sales, Arieh Anthony Katz
Cervical cancer is the leading gynaecological malignancy in Southern Africa. The main causal factor for development of the disease is infection of the cervix with human papillomavirus. It is a multi-step disease with several contributing co-factors including multiple sexual partners, a compromised immune system and cervical inflammation caused by infections with Chlamydia trachomatis or Neisseria gonorrhoeae. Inflammation involves extensive tissue remodelling events which are orchestrated by complex networks of cytokines, chemokines and bio-active lipids working across multiple cellular compartments to maintain tissue homeostasis...
June 2012: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Jaffet Seda, Yaniris Avellanet, Fernando J Roca, Eduardo Hernández, Sharee A Umpierre, Josefina Romaguera
OBJECTIVE: Approximately 30% of women diagnosed with cervical cancer are in their childbearing years, and 5-8% of pregnant women seeking prenatal care are found to have an abnormal Papanicolaou smear. Prenatal visits are an excellent opportunity for cervical cytology testing and patient education because of close follow-up. The objective of this study is to examine the overall prevalence of cervical dysplasia and associated risk factors in pregnant women aged 15 to 30 years attending the high-risk obstetrics clinics at the University Hospital in San Juan, Puerto Rico between December 2005 and May 2007...
March 2011: Puerto Rico Health Sciences Journal
Rosita Verteramo, Alessandra Pierangeli, Emanuela Mancini, Ettore Calzolari, Mauro Bucci, John Osborn, Rosa Nicosia, Fernanda Chiarini, Guido Antonelli, Anna Marta Degener
BACKGROUND: High grade HPV infections and persistence are the strongest risk factors for cervical cancer. Nevertheless other genital microorganisms may be involved in the progression of HPV associated lesions. METHODS: Cervical samples were collected to search for human Papillomavirus (HPV), bacteria and yeast infections in gynaecologic outpatients. HPV typing was carried out by PCR and sequencing on cervical brush specimens. Chlamydia trachomatis was identified by strand displacement amplification (SDA) and the other microorganisms were detected by conventional methods...
2009: BMC Infectious Diseases
Micheline de Lucena Oliveira, Melania Maria Ramos de Amorim, Alex Sandro Rolland de Souza, Lúcia Cristina Bezerra de Albuquerque, Aurélio Antônio Ribeiro da Costa
OBJECTIVES: To determine the frequency of Chlamydia trachomatis infection in patients with and without intraepithelial cervical lesions attended at specialized ambulatory in Recife (2007) and its association with biologic and demographic variables, habits, reproductive, clinical and gynecologic characteristics. METHODS: A cross-sectional study was conducted including 70 women (35 with cytological cervical lesions and 35 with normal smears). Colposcopy and biopsy when necessary were performed and Chlamydia infection was determined by direct immunofluorescence...
November 2008: Revista da Associação Médica Brasileira
Jesus Paula Carvalho, Filomena Marino Carvalho
Ovarian cancer is a highly lethal disease and its underlying biology is poorly understood. Prophylactic salpingo-oophorectomies in BRCA + women have recently implicated the fimbria as a site of origin for high-grade serous carcinoma and its intraepithelial precursors. This suggests that at least some ovarian cancers, probably the most aggressive ones, may not originate in the ovary itself, but rather may arise in the uterine tubes. Chronic inflammation is associated with carcinogenesis in several tissues, including liver, esophagogastric junction (cardia), and the uterine cervix...
November 2008: Medical Hypotheses
Rolando Herrero, Allan Hildesheim, Ana C Rodríguez, Sholom Wacholder, Concepción Bratti, Diane Solomon, Paula González, Carolina Porras, Silvia Jiménez, Diego Guillen, Jorge Morales, Mario Alfaro, Jean Cyr, Kerrygrace Morrisey, Yenory Estrada, Bernal Cortés, Lidia Ana Morera, Enrique Freer, John Schussler, John Schiller, Douglas Lowy, Mark Schiffman
We report the rationale, design, methods and details of participation of a community-based, double-blind, randomized clinical trial of an HPV 16 and 18 vaccine conducted in two provinces of Costa Rica to investigate the efficacy and population impact of the vaccine in the prevention of cervical cancer precursors. More than 24,000 women between 18 and 25 years of age were invited to participate and pre-screened for eligibility, with recruitment of 7466 women (30% of those pre-screened, 59% of those eligible) who were randomized to receive 3 doses of the HPV vaccine or hepatitis A vaccine as control...
September 2, 2008: Vaccine
Francisco Danilo Ferreira de Paula, Ana Paula Fernandes, Bianca Bianco do Carmo, Daniela Cristina Duarte Vieira, Miriam Santos Dutra, Caleb Guedes Miranda dos Santos, Maria do Carmo M Souza, Túlio César Alvim Andrade, Annamaria Ravara Vago, Paula Avila Fernandes
It has been suggested that Chlamydia trachomatis (CT) and human papillomaviruses (HPV) co-infection could contribute to development of intraepithelial lesions. In this study, HPV and CT-DNA were investigated in 250 cervicovaginal samples of patients from Minas Gerais, Brazil. The cytological analysis revealed that 70% of samples (175) were negative, 5.2% (13) presented atypical squamous or glandular cells of undetermined significance (ASCUS/AGUS), 12.4% (31) presented low-grade squamous intraepithelial lesion (LSIL), 10...
April 2007: Diagnostic Cytopathology
Margaret M Madeleine, Tarja Anttila, Stephen M Schwartz, Pekka Saikku, Maija Leinonen, Joseph J Carter, Michelle Wurscher, Lisa G Johnson, Denise A Galloway, Janet R Daling
Human papillomavirus (HPV) is the central etiologic factor for cervical cancer, and prior studies suggested C. trachomatis may act as an HPV cofactor. We examined the C. trachomatis-cervical cancer association by serotype, histology, HPV type in the tumor, and other HPV cofactors. We conducted a population-based study in the Seattle-Puget Sound area of 302 women with invasive squamous cell carcinomas (SCC), 185 women with adenocarcinomas of the cervix (AC), and 318 HPV seropositive control women. The risk of SCC associated with antibodies to C...
February 1, 2007: International Journal of Cancer. Journal International du Cancer
Gerardo D Deluca, Héctor M Marin, Eduardo Schelover, Estela M Chamorro, Lilian Vicente, Monica Albhom, Jose M Alonso
The presence of Chlamydia trachomatis and human papillomavirus (HPV) was evaluated by PCR technique in 189 sexually active women, between 15 and 58 years old, with cytological abnormalities in their uterine cervical epithelium and belonging to a region of Argentina with high incidence of cervical cancer. Risk factors in relation to chlamydial infection were also analyzed. Total prevalence for C. trachomatis infection was 24.9%, but there was a significant difference between prevalence in low socio-economical level (32...
2006: Medicina
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