keyword
https://read.qxmd.com/read/37218818/human-papillomavirus-prevalence-and-associated-factors-in-indigenous-women-in-ecuador-a-cross-sectional-analytical-study
#21
JOURNAL ARTICLE
José Ortiz Segarra, Bernardo Vega Crespo, Alfredo Campoverde Cisneros, Katherine Salazar Torres, Dayanara Delgado López, Stalin Ortiz
Cervical cancer (CC) is the second leading cause of death from malignancy in women in Ecuador. Human papillomavirus (HPV) is the main causative agent of CC. Although several studies have been conducted on HPV detection in Ecuador, there are limited data on indigenous women. This cross-sectional study aimed to analyze the prevalence of HPV and associated factors in women from the indigenous communities of Quilloac, Saraguro and Sevilla Don Bosco. The study included 396 sexually active women belonging to the aforementioned ethnicities...
May 18, 2023: Infectious Disease Reports
https://read.qxmd.com/read/37175971/vaginal-and-cervical-microbiota-composition-in-patients-with-endometrial-cancer
#22
JOURNAL ARTICLE
Bartłomiej Barczyński, Karolina Frąszczak, Ewelina Grywalska, Jan Kotarski, Izabela Korona-Głowniak
According to recent data, changes in the vaginal microbiota could affect the risk of gynaecological cancers. Women suffering from endometrial cancer present significant changes in cervicovaginal microbiota composition. The objective of our study was to characterize the cervicovaginal microbiota of women undergoing hysterectomy due to benign disease, atypical hyperplasia, and endometrial cancer; The study included 96 patients, who undergone surgical treatment due to benign uterine disease, precancerous endometrial lesion, and endometrial cancer...
May 5, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37155906/the-chlamydia-trachomatis-type-iii-secreted-effector-protein-cteg-induces-centrosome-amplification-through-interactions-with-centrin-2
#23
JOURNAL ARTICLE
Brianna Steiert, Carolina M Icardi, Robert Faris, Paige N McCaslin, Parker Smith, Aloysius J Klingelhutz, Peter M Yau, Mary M Weber
The centrosome is the main microtubule organizing center of the cell and is crucial for mitotic spindle assembly, chromosome segregation, and cell division. Centrosome duplication is tightly controlled, yet several pathogens, most notably oncogenic viruses, perturb this process leading to increased centrosome numbers. Infection by the obligate intracellular bacterium Chlamydia trachomatis ( C.t. ) correlates with blocked cytokinesis, supernumerary centrosomes, and multipolar spindles; however, the mechanisms behind how C...
May 16, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37107694/unraveling-the-dysbiosis-of-vaginal-microbiome-to-understand-cervical-cancer-disease-etiology-an-explainable-ai-approach
#24
JOURNAL ARTICLE
Karthik Sekaran, Rinku Polachirakkal Varghese, Mohanraj Gopikrishnan, Alsamman M Alsamman, Achraf El Allali, Hatem Zayed, George Priya Doss C
Microbial Dysbiosis is associated with the etiology and pathogenesis of diseases. The studies on the vaginal microbiome in cervical cancer are essential to discern the cause and effect of the condition. The present study characterizes the microbial pathogenesis involved in developing cervical cancer. Relative species abundance assessment identified Firmicutes , Actinobacteria , and Proteobacteria dominating the phylum level. A significant increase in Lactobacillus iners and Prevotella timonensis at the species level revealed its pathogenic influence on cervical cancer progression...
April 18, 2023: Genes
https://read.qxmd.com/read/37065642/non-genetic-factors-and-risk-of-cervical-cancer-an-umbrella-review-of-systematic-reviews-and-meta-analyses-of-observational-studies
#25
REVIEW
Xin-Yu Li, Gang Li, Ting-Ting Gong, Jia-Le Lv, Chang Gao, Fang-Hua Liu, Yu-Hong Zhao, Qi-Jun Wu
Objectives: The association between non-genetic risk factors and cervical cancer (CC) remains controversial and unclear. This umbrella review was conducted to evaluate and synthesize previously published systematic reviews and meta-analyses related to non-genetic factors and CC risk. Methods: We searched PubMed, Web of Science, and EMBASE to identify studies investigating the association between extragenetic factors and CC risk. For each article, we calculated the summary effect size and the 95% confidence interval...
2023: International Journal of Public Health
https://read.qxmd.com/read/36985236/alterations-of-vaginal-microbiota-and-chlamydia-trachomatis-as-crucial-co-causative-factors-in-cervical-cancer-genesis-procured-by-hpv
#26
REVIEW
Ciro Gargiulo Isacco, Mario G Balzanelli, Stefania Garzone, Mara Lorusso, Francesco Inchingolo, Kieu C D Nguyen, Luigi Santacroce, Adriana Mosca, Raffaele Del Prete
Chlamydia trachomatis and human papillomavirus (HPV) are the most common pathogens found in sexually transmitted infections (STIs), and both are known to increase the risk of cervical cancer (CC) and infertility. HPV is extremely common worldwide, and scientists use it to distinguish between low-risk and high-risk genotypes. In addition, HPV transmission can occur via simple contact in the genital area. From 50 to 80% of sexually active individuals become infected with both C. trachomatis and HPV viruses during their lifetime, and up to 50% become infected with an HPV oncogenic genotype...
March 6, 2023: Microorganisms
https://read.qxmd.com/read/36950601/prevalence-of-coinfections-in-a-cross-sectional-cohort-of-women-screened-for-multiple-pathogens-in-peru
#27
JOURNAL ARTICLE
Priscilla Pella-Saavedra, Fatima Ramos-Vallejos, Juana Del Valle-Mendoza, Lorena Becerra-Goicochea, Wilmer Silva-Caso, Luis Pinillos-Vilca, Angela Cornejo-Tapia, Johanna Martins-Luna, Ronald Aquino-Ortega, Hugo Carrillo-Ng, Miguel Angel Aguilar-Luis
OBJECTIVE: To determine the prevalence and risk factors of sexually transmitted infections (STIs) including Chlamydia trachomatis , Ureaplasma urealyticum and Mycoplasma genitalium among asymptomatic women with human papillomavirus (HPV) infection. METHODS: A cross-sectional study was performed in 842 asymptomatic women from Cajamarca, Peru. The pathogens were detected using polymerase chain reaction (PCR) and the results were analyzed according to the HPV status: high-risk HPV, low-risk HPV and negative for HPV...
March 2023: Heliyon
https://read.qxmd.com/read/36851657/prevalence-of-human-papillomavirus-hpv-among-females-in-the-general-population-of-the-split-and-dalmatia-county-and-its-association-with-genital-microbiota-and-infections-a-prospective-study
#28
JOURNAL ARTICLE
Vanja Kaliterna, Petar Kaliterna, Lidija Pejkovic, Robert Vulic, Linda Zanchi, Karmen Cerskov
We conducted a prospective study with the aim of determining HPV prevalence and type distribution in the general female population of Southern Croatia (SDC), and to detect the presence of other microorganisms in the lower part of the female reproductive system and their possible influence on the frequency of HPV infection. Data were collected during routine check-up exams. All participants were examined by a gynecologist, and cervico-vaginal scrapings/swabs were collected, for cytological (Pap smear) and microbiological (for bacterial growth, genital mycoplasmas, chlamydia, and HPV) analysis...
February 5, 2023: Viruses
https://read.qxmd.com/read/36834525/bacterial-infections-and-cancer-exploring-this-association-and-its-implications-for-cancer-patients
#29
REVIEW
Kafayat Yusuf, Venkatesh Sampath, Shahid Umar
Bacterial infections are common in the etiology of human diseases owing to the ubiquity of bacteria. Such infections promote the development of periodontal disease, bacterial pneumonia, typhoid, acute gastroenteritis, and diarrhea in susceptible hosts. These diseases may be resolved using antibiotics/antimicrobial therapy in some hosts. However, other hosts may be unable to eliminate the bacteria, allowing them to persist for long durations and significantly increasing the carrier's risk of developing cancer over time...
February 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36773299/elimination-of-human-papillomavirus-and-cervical-pathological-microbiota-with-photodynamic-therapy-in-women-from-mexico-city-with-cervical-intraepithelial-neoplasia-i
#30
JOURNAL ARTICLE
María Teresa López-Cárdenas, Adriana Jiménez, Araceli Espinosa-Montesinos, Elizabeth Maldonado-Alvarado, Martha Olivia Osorio-Peralta, Alejandro Martinez-Escobar, Alejandra Moreno-Vázquez, Ma Guadalupe Aguilera-Arreola, Eva Ramón-Gallegos
Cervical carcinoma (CC) is the second cause of cancer death in Mexican women. It starts with premalignant lesions known as Intraepithelial Cervical Neoplasia (CIN) that can develop due to infection by Human Papillomavirus (HPV) and other microorganisms. Current CIN therapy involves invasive methods that affect cervix integrity and fertility; we propose the use of photodynamic therapy (PDT) as a strategy with few side effects. In this work, the effectiveness of PDT for CIN I, HPV and pathogenic vaginal microbiota elimination in 29 women of Mexico City with CIN I, CIN I + HPV and HPV diagnosis was determined...
February 11, 2023: Photochemistry and Photobiology
https://read.qxmd.com/read/36695575/in-search-of-a-mechanistic-link-between-chlamydia-trachomatis-induced-cellular-pathophysiology-and-oncogenesis
#31
REVIEW
Brianna Steiert, Robert Faris, Mary M Weber
Centrosome duplication and cell cycle progression are essential cellular processes that must be tightly controlled to ensure cellular integrity. Despite their complex regulatory mechanisms, microbial pathogens have evolved sophisticated strategies to co-opt these processes to promote infection. While misregulation of these processes can greatly benefit the pathogen, the consequences to the host cell can be devastating. During infection, the obligate intracellular pathogen Chlamydia trachomatis induces gross cellular abnormalities, including supernumerary centrosomes, multipolar spindles, and defects in cytokinesis...
January 25, 2023: Infection and Immunity
https://read.qxmd.com/read/36565970/chlamydia-trachomatis-infection-co-operatively-enhances-hpv-e6-e7-oncogenes-mediated-tumorigenesis-and-immunosuppression
#32
JOURNAL ARTICLE
Naveen Challagundla, Jean Chrisophe-Bourdon, Reena Agrawal-Rajput
Chlamydia trachomatis and human papilloma virus (HPV) are the two most common sexually transmitted infections among women. HPV infection can increase the risk of cervical cancer and infertility while C. trachomatis induces pelvic inflammatory disease. Here, we elucidate the molecular conundrum of the co-infection of HPV and C. trachomatis infection and their outcome with respect to cervical cancer. HPV infection was mimicked by overexpression of HPV 16 E6-E7 or using human cervical cell lines SiHa and C33a (with and without HPV 16 respectively)...
December 21, 2022: Microbial Pathogenesis
https://read.qxmd.com/read/36555661/ovarian-microbiota-ovarian-cancer-and-the-underestimated-role-of-hpv
#33
JOURNAL ARTICLE
Massimiliano Cazzaniga, Marco Cardinali, Francesco Di Pierro, Alexander Bertuccioli
In recent years, many studies have highlighted the possible close correlation between human diseases and definite patterns of microbial organisms colonizing various organs. Even at sites traditionally considered sterile, such as the upper female reproductive tract (FRT), it is now well-recognized as hosting a low biomass of different bacterial phyla. Additionally, the data from recent studies highlight a possible link between lower and upper FRT dysbiosis with a potential predisposition to cervical and ovarian cancer...
December 16, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36447988/comment-on-chlamydia-infection-as-a-risk-factor-for-cervical-cancer-a-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Mohammad Bagher Shamsi, Maryam Mirzaei
No abstract text is available yet for this article.
June 2022: Iranian Journal of Public Health
https://read.qxmd.com/read/36447984/response-comment-on-chlamydia-infection-as-a-risk-factor-for-cervical-cancer-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Anaanthan Bhuvanendran Pillai, Nazarudin Safian
No abstract text is available yet for this article.
June 2022: Iranian Journal of Public Health
https://read.qxmd.com/read/36437562/sexually-transmitted-diseases-in-cancer-patients-diagnosed-under-the-age-of-20-years-a-national-registry-based-cohort-study-from-finland
#36
JOURNAL ARTICLE
Liisa Korhonen, Laura Madanat-Harjuoja, Elli Hirvonen, Janne Pitkäniemi, Nea Malila, Mervi Taskinen
BACKGROUND: Adolescents with chronic diseases are shown to be vulnerable for risky sexual behavior. Childhood cancer patients seem to engage in risky health behaviors as frequently as general population, but little is known about sexual issues in this group of patients. MATERIAL AND METHODS: We characterized the risk for sexually transmitted diseases (STD) in a Finnish population-based cohort of over 6,000 childhood cancer patients diagnosed with cancer under the age of 20 years between 1971 and 2009, compared with over 30,000 age- and sex -matched population comparisons...
November 27, 2022: Acta Oncologica
https://read.qxmd.com/read/36329823/new-insights-into-i-chlamydia-i-pathogenesis-role-of-leukemia-inhibitory-factor
#37
REVIEW
Jun Wang, Katherine Wang
<i>Chlamydia trachomatis (Ct)</i> is the leading cause of bacterial sexually transmitted infections worldwide. Since the symptoms of <i>Ct</i> infection are often subtle or absent, most people are unaware of their infection until they are tested or develop severe complications such as infertility. It is believed that the primary culprit of <i>Ct</i>-associated tissue damage is unresolved chronic inflammation, resulting in aberrant production of cytokines, chemokines, and growth factors, as well as dysregulated tissue influx of innate and adaptive immune cells...
2022: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/36230832/does-lactobacillus-exert-a-protective-effect-on-the-development-of-cervical-and-endometrial-cancer-in-women
#38
REVIEW
Karolina Frąszczak, Bartłomiej Barczyński, Adrianna Kondracka
Cervical cancer is a significant health problem with increasing occurrence and mortality. This infection-associated tumour is caused by the human papillomavirus (HPV). HPV infection is cleared by the immune system within 6-18 months in most patients; however, persistent high-risk HPV (hrHPV) infections can lead to the development of cervical cancer. Virus persistence is promoted by immunodeficiency, Chlamydia trachomatis infection, smoking, and age, as well as the imbalance of cervicovaginal microbiota and inflammation...
October 7, 2022: Cancers
https://read.qxmd.com/read/36042092/gonorrhea-and-chlamydia-testing-and-case-rates-among-women-veterans-in-the-veterans-health-administration
#39
JOURNAL ARTICLE
Shimrit Keddem, Marissa Maier, Carolyn Gardella, Joleen Borgerding, Elliott Lowy, Maggie Chartier, Sally Haskell, Ronald G Hauser, Lauren A Beste
BACKGROUND: United States (US) rates of sexually transmitted infection (STI) in women, especially gonorrhea and chlamydia, have increased over the past decade. Women Veterans may be at increased risk for STIs due to high rates of sexual trauma. Despite the availability of effective diagnostic tests and evidence-based guidelines for annual screening among sexually active women under age 25, screening rates for gonorrhea and chlamydia remain low in the US and among Veterans. OBJECTIVE: To examine patient characteristics and health system factors associated with gonorrhea and chlamydia testing and case rates among women Veterans in the Veterans Health Administration (VHA) in 2019...
August 30, 2022: Journal of General Internal Medicine
https://read.qxmd.com/read/35981863/how-did-the-covid-19-pandemic-affect-access-to-condoms-chlamydia-and-hiv-testing-and-cervical-cancer-screening-at-a-population-level-in-britain-natsal-covid
#40
JOURNAL ARTICLE
Emily Dema, Pam Sonnenberg, Jo Gibbs, Anne Conolly, Malachi Willis, Julie Riddell, Raquel Bosó Pérez, Andrew J Copas, Clare Tanton, Chris Bonell, Clarissa Oeser, Soazig Clifton, Magnus Unemo, Catherine H Mercer, Kirstin R Mitchell, Nigel Field
OBJECTIVES: To investigate how differential access to key interventions to reduce STIs, HIV and their sequelae changed during the COVID-19 pandemic. METHODS: British participants (18-59 years) completed a cross-sectional web survey 1 year (March-April 2021) after the initial lockdown in Britain. Quota-based sampling and weighting resulted in a quasi-representative population sample. We compared Natsal-COVID data with Natsal-3, a household-based probability sample cross-sectional survey (16-74 years) conducted in 2010-2012...
June 2023: Sexually Transmitted Infections
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