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https://www.readbyqxmd.com/read/30006482/a-preventive-injection-of-endothelial-progenitor-cells-prolongs-lifespan-in-stroke-prone-spontaneously-hypertensive-rats
#1
Cheng Peng, Xiao-Hui Dong, Jia-Lin Liu, Yu-Long Tao, Chun-Fang Xu, Li-Ping Wang, Chun-Long Liu, Ding-Feng Su, Xia Tao, Chuan Zhang, Alex F Chen, He-Hui Xie
There is a pressing need for new approaches to preventing stroke. Endothelial progenitor cells (EPCs) promote vascular repair and revascularization in the ischemic brain. This study sought to evaluate whether preventive delivery of EPCs could prevent or protect against stroke. Stroke-prone spontaneously hypertensive rats (SHR-SP) received a single injection of EPCs, and their survival time was monitored. In addition, at 28 and/or 42 days after a single injection of EPCs, SHR-SP and mice were subjected to cerebral ischemia, and cerebral ischemic injury, local angiogenesis and in vivo EPC integration were determined...
July 13, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/30006333/impact-of-frailty-on-clinical-outcomes-in-patients-with-critical-limb-ischemia
#2
Yasuaki Takeji, Kyohei Yamaji, Yusuke Tomoi, Jin Okazaki, Kiyoshi Tanaka, Ayumu Nagae, Hiroyuki Jinnouchi, Seiichi Hiramori, Yoshimitsu Soga, Kenji Ando
BACKGROUND: The predictive ability of patient frailty on clinical outcomes after revascularization in patients with critical limb ischemia remains largely unknown. METHODS AND RESULTS: We enrolled 643 patients with critical limb ischemia treated with endovascular therapy (N=486) or bypass surgery (N=157) in January 2010 to January 2016, and prospectively assessed them using a 9-level clinical frailty scale (CFS). Patients were divided into 3 groups according to CFS levels: low (CFS level, 1-3; N=234), intermediate (CFS level, 4-6; N=196), and high (CFS level, 7-9; N=213) groups...
July 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30006331/cardiovascular-and-noncardiovascular-death-after-percutaneous-coronary-intervention-insights-from-32-882-patients-enrolled-in-21-randomized-trials
#3
Sorin J Brener, Giuseppe Tarantini, Martin B Leon, Patrick W Serruys, Pieter C Smits, Clemens von Birgelen, Aaron Crowley, Ori Ben-Yehuda, Gregg W Stone
BACKGROUND: Despite advances in technology and technique, a substantial proportion of patients still die within several years after percutaneous coronary intervention (PCI). The relative rates of cardiovascular and noncardiovascular death after PCI remain uncertain. METHODS AND RESULTS: We pooled individual patient-level data from 21 randomized clinical trials of PCI performed in 32 882 patients. All studies had independent adjudication of clinical events. We calculated the relative ratio of cardiovascular to noncardiovascular death in each trial up to 5 years and identified predictors of all-cause, cardiovascular, and noncardiovascular death...
July 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30006330/benefit-of-prolonged-dual-antiplatelet-therapy-after-implantation-of-drug-eluting-stent-for-coronary-bifurcation-lesions-results-from-the-coronary-bifurcation-stenting-registry-ii
#4
Woo Jin Jang, Sung Gyun Ahn, Young Bin Song, Seung-Hyuk Choi, Woo Jung Chun, Ju Hyeon Oh, Sung Woo Cho, Bum Sung Kim, Jung Han Yoon, Bon-Kwon Koo, Cheol Woong Yu, Yang Soo Jang, Seung-Jea Tahk, Hyo-Soo Kim, Hyeon-Cheol Gwon, Sung Yun Lee, Joo-Yong Hahn
BACKGROUND: Whether prolonged dual antiplatelet therapy (DAPT) improves clinical outcomes after percutaneous coronary intervention for coronary bifurcation lesion is uncertain. METHODS AND RESULTS: We evaluated 2082 patients who were treated with drug-eluting stent for bifurcation lesions and were event free (no death, myocardial infarction [MI], cerebrovascular accident, stent thrombosis, or any revascularization) at 12 months after the index procedure. Patients were divided into 2 groups: DAPT ≥12-month group (n=1776) and DAPT <12-month group (n=306)...
July 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30005151/amiodarone-refractory-electrical-storm-post-revascularization-for-anterior-st-elevation-myocardial-infarction-a-case-report-and-brief-review-of-the-literature
#5
Chirag K Desai, Udit Bhatnagar, Maria Stys
"Electrical storm" is a life-threatening condition defined as the occurrence of at least two episodes of malignant ventricular arrhythmia in a 24-hour period despite anti-arrhythmic therapy. It leads to unpredictable degrees of clinical instability - in the most severe cases mechanical support for circulation and oxygenation and for definitive therapy radiofrequency ablation or cardiac sympathetic denervation. We describe a case of medication refractory electrical storm complicating severe left ventricular dysfunction after an anterior ST-elevation myocardial infarction...
June 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/30004949/how-deep-is-your-lesion-extreme-guideliner-v3-intubation-through-rima-graft-to-treat-a-distal-left-anterior-descending-artery-stenosis
#6
Domenico D'Amario, Mattia Galli, Rocco Vergallo, Filippo Crea, Italo Porto
: Guidelines allowed a complex RIMA graft cannulation and the delivery of two DES throw a tortuous RIMA graft to a mid-distal left anterior descending lesion. Dissection of the RIMA graft was a complication but a successful revascularization was finally achieved.
July 11, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/30004922/timing-of-carotid-endarterectomy-after-stroke-retrospective-review-of-prospectively-collected-national-database
#7
Adam Tanious, Alexander B Pothof, Laura T Boitano, Alaska A Pendleton, Linda J Wang, Gert J de Borst, David W Rattner, Marc L Schermerhorn, Mohammad H Eslami, Mahmoud B Malas, Matthew J Eagleton, William Darrin Clouse, Mark F Conrad
OBJECTIVE: Our objective was to identify the postoperative risk associated with different timing intervals of repair. BACKGROUND: Timing of carotid intervention in poststroke patients is widely debated with the scales balanced between increased periprocedural risk and recurrent neurologic event. National database reviews show increased risk to patients treated within the first 2 days of a neurologic event compared to those treated after 6 days. METHODS: Utilizing Vascular Quality Initiative data, all carotid interventions performed on stroke patients between the years 2012 and 2017 were queried...
July 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30004916/no-clinical-benefit-of-intramuscular-delivery-of-bone-marrow-derived-mononuclear-cells-in-nonreconstructable-peripheral-arterial-disease-results-of-a-phase-iii-randomized-controlled-trial
#8
Jan H N Lindeman, Jaap Jan Zwaginga, Graziella Kallenberg-Lantrua, Rob C van Wissen, Abbey Schepers, Hajo J van Bockel, Willem E Fibbe, Jaap F Hamming
BACKGROUND AND AIMS: Prospects for no-option, end-stage peripheral artery disease (PAD) patients remain poor. Although results from open and semiblinded studies fuel hope for cell-based strategies in no-option patients, so far conclusions from the available placebo-controlled studies are not supportive. With the intention to end the remaining controversy with regard to cell therapy for PAD we conducted a confirmatory, double-blinded randomized placebo-controlled phase 3 trial. STUDY DESIGN: This randomized controlled trial was registered (NCT00539266)...
July 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30003829/prognostic-factors-of-ulcer-healing-and-amputation-free-survival-in-patients-with-critical-limb-ischemia
#9
Tadashi Furuyama, Toshihiro Onohara, Sho Yamashita, Ryosuke Yoshiga, Keiji Yoshiya, Kentaro Inoue, Koichi Morisaki, Ryoichi Kyuragi, Takuya Matsumoto, Yoshihiko Maehara
Objective A multidisciplinary approach is required to treat critical limb ischemia. We determined the poor prognostic factors of ischemic ulcer healing after optimal arterial revascularization, and assessed the efficacy of the medication therapy using cilostazol, which is a selective inhibitor of phosphodiesterase 3. Methods In this retrospective, single-center, cohort study, 129 limbs that underwent infrainguinal arterial revascularization for Rutherford class 5 critical limb ischemia were reviewed. The primary end point was the ulcer healing time after arterial revascularization...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/30001611/single-aortic-branch-device-the-mona-lsa-experience
#10
Hervé Rousseau, Paul Revel-Mouroz, Bertrand Saint Lebes, Jean-Pierre Bossavy, Olivier Meyrignac, Fatima-Zohra Mokrane
INTRODUCTION: Endovascular treatment of aortic arch pathologies is challenging due to its complex anatomical architecture and the presence of vital collateral branches. This paper aims to provide an overview of the currently available and future endovascular options for these diseases, particularly regarding branched stent-grafts and the Mona-LSA device. EVIDENCE ACQUISITION AND EVIDENCE SYNTHESIS: After discussing the indications for revascularization of supra-aortic trunks in endovascular aortic repair, we present the principles, benefits and drawbacks of the main modern methods to overcome an insufficient proximal landing zone, ie...
July 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29999468/risk-of-subsequent-stroke-with-or-without-extracranial-intracranial-bypass-surgery-a-nationwide-retrospective-population-based-study
#11
XianXiu Chen, Cheng-Li Lin, Yuan-Chih Su, Kuan-Fei Chen, Shih-Wei Lai, Sung-Tai Wei, Ching-Tien Peng, Cheng-Di Chiu, Shwn-Huey Shieh, Chun-Chung Chen
OBJECTIVE Although no benefits of extracranial-intracranial (EC-IC) bypass surgery in preventing secondary stroke have been identified previously, the outcomes of initial symptomatic ischemic stroke and stenosis and/or occlusion among the Asian population in patients with or without bypass intervention have yet to be discussed. The authors aimed to evaluate the subsequent risk of secondary vascular disease and cardiac events in patients with and without a history of this intervention. METHODS This retrospective nationwide population-based Taiwanese registry study included 205,991 patients with initial symptomatic ischemic stroke and stenosis and/or occlusion, with imaging data obtained between 2001 and 2010...
June 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29998803/extracranial-to-intracranial-bypass-for-pressor-dependent-cerebrovascular-insufficiency-modified-classification-and-representative-case
#12
Daniel M Heiferman, John R Souter, Matthew R Reynolds, Douglas E Anderson, Joseph C Serrone
BACKGROUND: While some randomized clinical trials have reduced the indications for cerebral revascularization in the secondary prevention of ischemic stroke, a distinct subset of patients with blood pressure augmentation dependent cerebrovascular insufficiency due to large vessel occlusions remains unaddressed. With the recent paradigm shifts in acute ischemic stroke care, the role of extracranial to intracranial (EC-IC) bypass must be re-addressed when endovascular intervention is not a feasible option...
July 12, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29997240/data-driven-approach-to-identify-subgroups-of-heart-failure-with-reduced-ejection-fraction-patients-with-different-prognoses-and-aldosterone-antagonist-response-patterns
#13
João Pedro Ferreira, Kevin Duarte, John J V McMurray, Bertram Pitt, Dirk J van Veldhuisen, John Vincent, Tariq Ahmad, Jasper Tromp, Patrick Rossignol, Faiez Zannad
BACKGROUND: Patients with heart failure with reduced ejection fraction have a poor prognosis. The identification of subgroups with different outcomes and treatment response patterns may help to tailor strategies to each individual patient. We present an exploratory study of patients enrolled in the EMPHASIS-HF trial (Eplerenone in Patients With Systolic Heart Failure and Mild Symptoms) using latent class analysis with validation using the EPHESUS trial (Eplerenone, a Selective Aldosterone Blocker, in Patients With Left Ventricular Dysfunction After Myocardial Infarction) to identify subgroups of patients with different prognosis and response to eplerenone therapy...
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29996912/stem-cell-therapy-for-diabetic-foot-ulcers-a-review-of-preclinical-and-clinical-research
#14
Lara Lopes, Ocean Setia, Afsha Aurshina, Shirley Liu, Haidi Hu, Toshihiko Isaji, Haiyang Liu, Tun Wang, Shun Ono, Xiangjiang Guo, Bogdan Yatsula, Jianming Guo, Yongquan Gu, Tulio Navarro, Alan Dardik
BACKGROUND: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials...
July 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29996661/extra-hepatic-islet-transplantation-validation-of-the-h-omental-matrix-islet-filling-homing-technique-on-a-rodent-model-using-an-alginate-carrier
#15
Anaïs Schaschkow, Séverine Sigrist, Carole Mura, Caroline Dissaux, Karim Bouzakri, Anne Lejay, Catherine Bruant-Rodier, Michel Pinget, Elisa Maillard
Following the tremendous development of hydrogels for cell therapy, there is now a growing need for surgical techniques to validate in vivo scaffold benefits for islet transplantation. Therefore, we propose a newly designed surgical procedure involving the injection of hydrogel-embedded pancreatic islets in the omentum, which is considered a favorable environment for cell survival and function. Our technique, called h-Omental Matrix Islet filliNG (hOMING) was designed to test the benefits of hydrogel on islet survival and function in vivo...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29996363/-effect-of-exogenous-stem-cells-from-apical-papillae-in-the-pulp-revascularization-treatment-for-the-immature-permanent-tooth-with-periapical-periodontitis
#16
J Yang, W J Wang, W Q Jia, Y M Zhao, L H Ge
Objective: To evaluate the effect of exogenous stem cells from apical papillae (SCAP) in the pulp revascularization treatment for the immature permanent tooth with periapical periodontitis in animal model. Methods: After the SCAP were isolated and cultured from the Beagle dogs, stem cell properties of these cells were characterized by analyzing their colony-forming ability, the expression of mesenchymal stem cell markers and the multidifferentiation characteristics including osteogenic, adipogenic, and chondrogenic potentials...
July 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29996000/a-systematic-review-and-meta-analysis-of-rescue-revascularization-with-arterial-conduits-in-liver-transplantation
#17
Tim Reese, Dimitri A Raptis, Christian E Oberkofler, Olivier de Rougemont, Georg P Györi, Martina Gosteli-Peter, Philipp Dutkowski, Pierre-Alain Clavien, Henrik Petrowsky
Although aorto-hepatic conduits (AHC) provide an effective technique for arterialization in liver transplantation (LT), when the native recipient artery is unusable, various publications report higher occlusion rates and impaired outcome compared to conventional anastomoses. This systematic review and meta-analysis investigates the published evidence of outcome and risk of AHC in LT using bibliographic databases and following the PRISMA guidelines. Primary and secondary outcome were artery occlusion as well as graft and patient survival...
July 11, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29995911/inferior-long-term-graft-survival-after-end-to-side-reconstruction-for-two-renal-arteries-in-living-donor-renal-transplantation
#18
Shigeyoshi Yamanaga, Angel Rosario, Danny Fernandez, Takaaki Kobayashi, Mehdi Tavakol, Peter G Stock, Sang-Mo Kang
Living donor kidneys with two arteries can be revascularized using various techniques depending on anatomy. We hypothesized that the revascularization technique could impact long-term outcomes. We retrospectively analyzed 1714 living donor renal transplants at our institution between 1999 and 2015. Three hundred and eleven kidneys had dual arteries, and these were categorized into 5 groups; end-to-side (n = 18), inferior epigastric artery (n = 21), direct anastomosis (n = 65), side-to-side (n = 126) and ligated (n = 81)...
2018: PloS One
https://www.readbyqxmd.com/read/29994809/should-functional-assessment-of-lesion-severity-be-used-to-guide-coronary-bypass
#19
Bobby Yanagawa, Subodh Verma, Akshay Bagai, John D Puskas
PURPOSE OF REVIEW: The purpose of this article is to investigate the potential role of fractional flow reserve (FFR) to guide surgical revascularization. RECENT FINDINGS: Coronary artery bypass is planned and executed primarily based on angiographic coronary anatomy. FFR is the most well-established tool for functional assessment of coronary lesions. Randomized trials have demonstrated the benefit of FFR-guided percutaneous coronary intervention (PCI) to determine the ischemic burden of intermediate lesions...
July 9, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29994806/what-is-the-state-of-hybrid-coronary-revascularization-in-2018
#20
Bobby Yanagawa, Kathryn Hong, Asim Cheema, Akshay Bagai, Subodh Verma
PURPOSE OF REVIEW: Hybrid coronary revascularization (HCR) combines minimally invasive surgical bypass with percutaneous coronary intervention (PCI) using drug-eluting stents, the goal being to leverage the strengths of each approach. Here we provide an update on HCR from the past 12 months. RECENT FINDINGS: HCR represents a minority of surgical revascularization cases from a small number of highly experienced surgical centers. Most single-center observational series show no differences in major cardiovascular outcomes comparing HCR and coronary artery bypass graft (CABG) or HCR and PCI...
July 9, 2018: Current Opinion in Cardiology
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