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https://www.readbyqxmd.com/read/29676794/classify-epithelium-stroma-in-histopathological-images-based-on-deep-transferable-network
#1
X Yu, H Zheng, C Liu, Y Huang, X Ding
Recently, the deep learning methods have received more attention in histopathological image analysis. However, the traditional deep learning methods assume that training data and test data have the same distributions, which causes certain limitations in real-world histopathological applications. However, it is costly to recollect a large amount of labeled histology data to train a new neural network for each specified image acquisition procedure even for similar tasks. In this paper, an unsupervised domain adaptation is introduced into a typical deep convolutional neural network (CNN) model to mitigate the repeating of the labels...
April 20, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29676591/a-retrospective-observational-study-on-biological-drug-treatment-in-a-daily-practice-serving-patients-with-psoriasis-in-japan
#2
Chika Ohata, Bungo Ohyama, Aya Nanri, Takako Shintani, Takekuni Nakama
BACKGROUND: In Japan, more than 5 years have passed since emergence of the first 3 biologics, infliximab, adalimumab, and ustekinumab, became available in daily practice; however, no data for drug survival was reported from Japan. OBJECTIVE: To study the long-term drug survival of infliximab, adalimumab, and ustekinumab used for Japanese psoriatic patients. METHODS: We retrieved data on all patients treated with biological agents and calculated the long-term drug survival for infliximab, adalimumab, and ustekinumab using our psoriasis registry (Kurume Psoriasis Registry: KURUPR) consisted of 343 patients by the end of March 2017...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29675948/pattern-of-care-and-survival-of-anaplastic-lymphoma-kinase-rearranged-non-small-cell-lung-cancer-alk-nsclc-in-an-australian-metropolitan-tertiary-referral-centre-a-retrospective-cohort-analysis
#3
Malinda Itchins, Sarah A Hayes, Anthony J Gill, Wendy Cooper, Rachel O'Connell, Viive M Howell, Stephen J Clarke, Nick Pavlakis
AIM: To report on the pattern of care and survival of anaplastic lymphoma kinase rearranged non-small cell lung cancer (ALK+NSCLC) in a real-world retrospective cohort from an Australian tertiary referral center. METHODS: Individuals with a pathological diagnosis of ALK+NSCLC via immunohistochemistry and fluorescence in situ hybridization and a radiological diagnosis of stage IV disease were eligible. Patients were identified via the Pathology Department specimen database and electronic patient chart review...
April 19, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29675797/treatment-intensification-in-type-2-diabetes-a-real-world-study-of-2-oad-regimens-glp-1-ras-or-basal-insulin
#4
Lawrence Blonde, Denis Raccah, Elisheva Lew, Juliana Meyers, Elena Nikonova, Mayank Ajmera, Keith L Davis, Monica Bertolini, Bruno Guerci
INTRODUCTION: Treatment guidelines recommend a stepwise approach to glycemia management in patients with type 2 diabetes (T2D), but this may result in uncontrolled glycated hemoglobin A1c (HbA1c) between steps. This retrospective analysis compared clinical and economic outcomes among patients with uncontrolled T2D initiating two oral antidiabetes drugs (OADs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), or basal insulin in a real-world setting. METHODS: Adults with T2D on OAD monotherapy were identified in the MarketScan claims database (2007-2014)...
April 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29674186/pulmonary-hypertension-real-world-data-from-a-portuguese-expert-referral-centre
#5
A Gomes, C Cruz, J Rocha, M Ricardo, M Vicente, A Melo, M Santos, L Carvalho, F Gonçalves, A Reis
BACKGROUND: Pulmonary hypertension (PH) is a heterogeneous, debilitating condition with highly relevant impact on functional capacity, quality of life, and life-expectancy. OBJECTIVES: This study aims to provide long-term data on the Portuguese PH population, by characterising the clinical presentation, evolution, and outcomes of PH patients in a specialised referral centre. METHODS: Retrospective analysis of a cohort of 101 patients with pre-capillary PH (pcPH) referenced to an expert tertiary care referral centre in northern Portugal from 2002 to 2013...
April 16, 2018: Pulmonology
https://www.readbyqxmd.com/read/29673604/concurrence-of-big-data-analytics-and-healthcare-a-systematic-review
#6
REVIEW
Nishita Mehta, Anil Pandit
BACKGROUND: The application of Big Data analytics in healthcare has immense potential for improving the quality of care, reducing waste and error, and reducing the cost of care. PURPOSE: This systematic review of literature aims to determine the scope of Big Data analytics in healthcare including its applications and challenges in its adoption in healthcare. It also intends to identify the strategies to overcome the challenges. DATA SOURCES: A systematic search of the articles was carried out on five major scientific databases: ScienceDirect, PubMed, Emerald, IEEE Xplore and Taylor & Francis...
June 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29673274/drug-wastage-and-costs-to-the-healthcare-system-in-the-care-of-patients-with-non-small-cell-lung-cancer-in-the-united-states
#7
Lisa M Hess, Zhanglin Lin Cui, Xiaohong Ivy Li, Ana B Oton, Scott Shortenhaus, Ian A Watson
BACKGROUND: Lung cancer is one of the most prevalent cancers in the United States. This study was designed to evaluate the actual drug wastage and cost to the healthcare system using patient-level retrospective observational electronic medical record (EMR) data from a cohort of lung cancer patients in the United States (US). METHODS: Data from the Flatiron Health advanced non-small cell lung cancer (NSCLC) cohort was used for this study. Drug administered amount (in mg) was used to determine an optimal set of available vial sizes to minimize waste...
April 19, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29672879/increased-left-atrial-size-is-associated-with-higher-atrial-fibrillation-recurrence-in-patients-treated-with-anti-arrhythmic-medications
#8
Saarang Mulukutla, Andrew D Althouse, Sandeep K Jain, Samir Saba
BACKGROUND: Atrial fibrillation (AF) is highly prevalent and antiarrhythmic therapy is often used to help with rhythm control. Some common echocardiographic parameters may be useful in predicting AF recurrence among these patients. OBJECTIVES: The purpose of this study was to evaluate the association between three common echocardiographic parameters [left atrial (LA) size, left ventricular ejection fraction (LVEF), and mitral regurgitation (MR)] and AF recurrence among patients treated with anti-arrhythmic medications...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29672524/point-of-care-tests-for-syphilis-and-yaws-in-a-low-income-setting-a-qualitative-study-of-healthcare-worker-and-patient-experiences
#9
Michael Marks, Tommy Esau, Rowena Asugeni, Relmah Harrington, Jason Diau, Hilary Toloka, James Asugeni, Eimhin Ansbro, Anthony W Solomon, David Maclaren, Michelle Redman-Maclaren, David C W Mabey
INTRODUCTION: The human treponematoses comprise venereal syphilis and the three non-venereal or endemic treponematoses yaws, bejel, and pinta. Serological assays remain the most common diagnostic method for all treponemal infections. Point-of-care tests (POCTs) for syphilis and yaws allow testing without further development of infrastructure in populations where routine laboratory facilities are not available. Alongside the test's performance characteristics assessed through diagnostic evaluation, it is important to consider broader issues when rolling out a POCT...
April 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29672182/oral-anticoagulant-use-in-cardiovascular-disorders-a-perspective-on-present-and-potential-indications-for-rivaroxaban
#10
A John Camm, Keith A A Fox
BACKGROUND: Four nonvitamin K antagonist oral anticoagulants (NOACs) have been approved for use in various cardiovascular indications. The direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors apixaban, edoxaban, and rivaroxaban are now increasingly used in clinical practice. For some of these agents, available data from real-world studies support the efficacy and safety data in phase III clinical trials. OBJECTIVES: This review aims to summarize the current status of trials and observational studies of oral anticoagulant use over the spectrum of cardiovascular disorders (excluding venous thrombosis), provide a reference source beyond stroke prevention for atrial fibrillation (AF) and examine the potential for novel applications in the cardiovascular field...
April 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29671915/estimating-long-term-treatment-effects-in-observational-data-a-comparison-of-the-performance-of-different-methods-under-real-world-uncertainty
#11
Simon J Newsome, Ruth H Keogh, Rhian M Daniel
In the presence of time-dependent confounding, there are several methods available to estimate treatment effects. With correctly specified models and appropriate structural assumptions, any of these methods could provide consistent effect estimates, but with real-world data, all models will be misspecified and it is difficult to know if assumptions are violated. In this paper, we investigate five methods: inverse probability weighting of marginal structural models, history-adjusted marginal structural models, sequential conditional mean models, g-computation formula, and g-estimation of structural nested models...
April 19, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29671627/the-impact-of-non-medical-switch-on-type-2-diabetes-patients-treated-with-canagliflozin-in-the-commercially-insured-us-population
#12
Lawrence Blonde, Chakkarin Burudpakdee, Victoria Divino, Brahim Bookhart, Jennifer Cai, Michael Pfeifer, Craig I Coleman
OBJECTIVE: To assess the impact of non-medical switch (NMS) from canagliflozin on antihyperglycemic agent (AHA) medication taking behavior. METHODS: This retrospective real-world database analysis included patients with type 2 diabetes with a prescription claim for canagliflozin between 8/2015 and 1/2016 using administrative claims and longitudinal prescription data. Patients with NMS from canagliflozin were identified as those with discontinuation or switch of canagliflozin and enrolled in a pharmacy benefit manager that removed CANA from formulary in 2016...
April 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29671314/emissions-during-and-real-world-frequency-of-heavy-duty-diesel-particulate-filter-regeneration
#13
Chris Ruehl, Jeremy D Smith, Yilin Ma, Jennifer Erin Shields, Mark Burnitzki, Wayne Sobieralski, Robert Ianni, Donald J Chernich, M-C Oliver Chang, John Francis Collins, Seungju Yoon, David Quiros, Shaohua Hu, Harry Dwyer
Recent tightening of particulate matter (PM) emission standards for heavy-duty engines has spurred the widespread adoption of diesel particulate filters (DPF), which need to be regenerated periodically to remove trapped PM. The total impact of DPFs therefore depends not only on their filtering efficiency during normal operation, but also on the emissions during and the frequency of regeneration events. We performed active (parked and driving) and passive regenerations on two heavy-duty diesel vehicles (HDDVs), and report the chemical composition of emissions during these events, as well as the efficiency with which trapped PM is converted to gas-phase products...
April 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29671284/comparative-cardiovascular-risks-of-dipeptidyl-peptidase-4-inhibitors-analyses-of-real-world-data-in-korea
#14
Kyoung Hwa Ha, Bongseong Kim, Hae Sol Shin, Jinhee Lee, Hansol Choi, Hyeon Chang Kim, Dae Jung Kim
BACKGROUND AND OBJECTIVES: To compare cardiovascular disease (CVD) risk associated with 5 different dipeptidyl peptidase-4 inhibitors (DPP-4is) in people with type 2 diabetes. METHODS: We identified 534,327 people who were newly prescribed sitagliptin (n=167,157), vildagliptin (n=67,412), saxagliptin (n=29,479), linagliptin (n=220,672), or gemigliptin (n=49,607) between January 2013 and June 2015 using the claims database of the Korean National Health Insurance System...
February 27, 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29671283/trends-and-outcomes-of-transcatheter-aortic-valve-implantation-tavi-in-korea-the-results-of-the-first-cohort-of-korean-tavi-registry
#15
Cheol Woong Yu, Won Jang Kim, Jung Min Ahn, Hyungdon Kook, Se Hun Kang, Jung Kyu Han, Young Guk Ko, Seung Hyuk Choi, Bon Kwon Koo, Kiyuk Chang, Hyo Soo Kim
BACKGROUND AND OBJECTIVES: There has been no nation-wide data on the outcomes of transcatheter aortic valve implantation (TAVI) after commercialization of TAVI in Korea. We report clinical features and outcomes of the first cohort of TAVI performed from Jun 2015 to Jun 2017 in Korea. METHODS: The first cohort of Korean-TAVI (K-TAVI) registry includes 576 consecutive patients with severe symptomatic aortic stenosis who underwent TAVI from 17 Korean hospitals for 2 years...
April 17, 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29670840/investigating-effect-of-rapamycin-and-metformin-on-angiogenesis-in-hepatocellular-carcinoma-cell-line
#16
Mandana Rastegar, Haji-Amin Marjani, Yaghoub Yazdani, Majid Shahbazi, Masoud Golalipour, Touraj Farazmandfar
Purpose: Human hepatocellular carcinoma is one of the most common causes of death in the world. Metformin and rapamycin may decrease the expression of VEGF protein and subsequently angiogenesis. The purpose of this study was to evaluate the effect of these two drugs on expression of VEGF protein and the cell proliferation in the hepatocellular carcinoma cell line (ATCC HB-8065). Methods: HepG2 was cultured in RPMI-1640 medium at 37°C for 48h as a pre-culture and then treated by different concentrations of metformin (0, 5, 10 and 20 mM) and rapamycin (0, 5, 10 and 20 nM) at different times (12, 24 and 48 h)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670759/temporal-prediction-of-in-hospital-falls-using-tensor-factorisation
#17
Haolin Wang, Qingpeng Zhang, Hing-Yu So, Angela Kwok, Zoie Shui-Yee Wong
In-hospital fall incidence is a critical indicator of healthcare outcome. Predictive models for fall incidents could facilitate optimal resource planning and allocation for healthcare providers. In this paper, we proposed a tensor factorisation-based framework to capture the latent features for fall incidents prediction over time. Experiments with real-world data from local hospitals in Hong Kong demonstrated that the proposed method could predict the fall incidents reasonably well (with an area under the curve score around 0...
April 2018: BMJ Innovations
https://www.readbyqxmd.com/read/29670397/effectiveness-of-fixed-site-high-frequency-transcutaneous-electrical-nerve-stimulation-in-chronic-pain-a-large-scale-observational-study
#18
Xuan Kong, Shai N Gozani
Objective: The objective of this study was to assess the effectiveness of fixed-site high-frequency transcutaneous electrical nerve stimulation (FS-TENS) in a real-world chronic pain sample. Background: There is a need for nonpharmacological treatment options for chronic pain. FS-TENS improved multisite chronic pain in a previous interventional study. Large observational studies are needed to further characterize its effectiveness. Methods: This retrospective observational cohort study examined changes in chronic pain measures following 60 days of FS-TENS use...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29670332/reevaluation-of-the-post-marketing-safety-of-shuxuening-injection-based-on-real-world-and-evidence-based-evaluations
#19
Can Wang, Qing-Ping Shi, Feng Ding, Xiao-Dong Jiang, Wei Tang, Mei-Ling Yu, Jian-Hua Zhu
Aim: To evaluate the factors influencing suspected hypersensitivity and adverse systemic reactions after Shuxuening injection and to provide innovative ideas and methods for the reevaluation of post-marketing safety of Shuxuening. Methods: This study used a prospective, nested case-control study design, combined with a prescription sequence analysis design method. It classified patients who exhibited trigger signals after administration of Shuxuening injection as suspected allergic patients and made comparisons with patients who did not report adverse effects to calculate the correlation between relevant risk factors and suspected allergic reactions...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29670138/differential-medial-temporal-lobe-and-parietal-cortical-contributions-to-real-world-autobiographical-episodic-and-autobiographical-semantic-memory
#20
Thackery I Brown, Jesse Rissman, Tiffany E Chow, Melina R Uncapher, Anthony D Wagner
Autobiographical remembering can depend on two forms of memory: episodic (event) memory and autobiographical semantic memory (remembering personally relevant semantic knowledge, independent of recalling a specific experience). There is debate about the degree to which the neural signals that support episodic recollection relate to or build upon autobiographical semantic remembering. Pooling data from two fMRI studies of memory for real-world personal events, we investigated whether medial temporal lobe (MTL) and parietal subregions contribute to autobiographical episodic and semantic remembering...
April 18, 2018: Scientific Reports
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