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https://www.readbyqxmd.com/read/29031013/intragenic-hypomethylation-of-dnmt3a-in-patients-with-myelodysplastic-syndrome
#1
Ying-Ying Zhang, Jing-Dong Zhou, Dong-Qin Yang, Pin-Fang He, Dong-Ming Yao, Zhen Qian, Jing Yang, Wen-Rong Xu, Jiang Lin, Jun Qian
BACKGROUND: DNMT3A is a DNA methyltransferase that acts in de novo methylation. Aberrant expression of DNMT3A has been reported in several human diseases, including myelodysplastic syndrome (MDS). However, the pattern of DNMT3A methylation remains unknown in MDS. METHODS: The present study was aimed to investigate the methylation status of DNMT3A intragenic differentially methylated region 2 (DMR2) using real-time quantitative methylation-specific PCR and analyze its clinical significance in MDS...
October 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29028869/mg-rast-version-4-lessons-learned-from-a-decade-of-low-budget-ultra-high-throughput-metagenome-analysis
#2
Folker Meyer, Saurabh Bagchi, Somali Chaterji, Wolfgang Gerlach, Ananth Grama, Travis Harrison, Tobias Paczian, William L Trimble, Andreas Wilke
As technologies change, MG-RAST is adapting. Newly available software is being included to improve accuracy and performance. As a computational service constantly running large volume scientific workflows, MG-RAST is the right location to perform benchmarking and implement algorithmic or platform improvements, in many cases involving trade-offs between specificity, sensitivity and run-time cost. The work in [Glass EM, Dribinsky Y, Yilmaz P, et al. ISME J 2014;8:1-3] is an example; we use existing well-studied data sets as gold standards representing different environments and different technologies to evaluate any changes to the pipeline...
September 26, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29028254/comparing-the-advanced-reach-tool-s-art-estimates-with-switzerland-s-occupational-exposure-data
#3
Nenad Savic, Bojan Gasic, Jody Schinkel, David Vernez
The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance has only been tested on a limited number of exposure data. The present study compares ART's estimates with exposure measurements collected over many years in Switzerland...
October 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29028214/dimensionality-reduction-in-multiple-ordinal-regression
#4
Jiabei Zeng, Yang Liu, Biao Leng, Zhang Xiong, Yiu-Ming Cheung
Supervised dimensionality reduction (DR) plays an important role in learning systems with high-dimensional data. It projects the data into a low-dimensional subspace and keeps the projected data distinguishable in different classes. In addition to preserving the discriminant information for binary or multiple classes, some real-world applications also require keeping the preference degrees of assigning the data to multiple aspects, e.g., to keep the different intensities for co-occurring facial expressions or the product ratings in different aspects...
October 10, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29028213/classification-of-imbalanced-data-by-oversampling-in-kernel-space-of-support-vector-machines
#5
Josey Mathew, Chee Khiang Pang, Ming Luo, Weng Hoe Leong
Historical data sets for fault stage diagnosis in industrial machines are often imbalanced and consist of multiple categories or classes. Learning discriminative models from such data sets is challenging due to the lack of representative data and the bias of traditional classifiers toward the majority class. Sampling methods like synthetic minority oversampling technique (SMOTE) have been traditionally used for such problems to artificially balance the data set before being trained by a classifier. This paper proposes a weighted kernel-based SMOTE (WK-SMOTE) that overcomes the limitation of SMOTE for nonlinear problems by oversampling in the feature space of support vector machine (SVM) classifier...
October 10, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29028211/online-heterogeneous-transfer-by-hedge-ensemble-of-offline-and-online-decisions
#6
Yuguang Yan, Qingyao Wu, Mingkui Tan, Michael K Ng, Huaqing Min, Ivor W Tsang
In this paper, we study the online heterogeneous transfer (OHT) learning problem, where the target data of interest arrive in an online manner, while the source data and auxiliary co-occurrence data are from offline sources and can be easily annotated. OHT is very challenging, since the feature spaces of the source and target domains are different. To address this, we propose a novel technique called OHT by hedge ensemble by exploiting both offline knowledge and online knowledge of different domains. To this end, we build an offline decision function based on a heterogeneous similarity that is constructed using labeled source data and unlabeled auxiliary co-occurrence data...
October 10, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29027615/assessment-of-the-role-of-everolimus-therapy-in-patients-with-renal-cell-carcinoma-based-on-daily-routine-and-recent-research-results
#7
Anikó Maráz, András Csejtei, Judit Kocsis, Miklós Szűcs, Zsuzsanna Kahán, György Bodoky, Magdolna Dank, László Mangel, János Révész, Zoltán Varga, Lajos Géczi
Everolimus is indicated for adults with metastatic renal cell carcinoma (mRCC) after failure of vascular endothelial growth factor receptor-tyrosine kinase inhibitors (TKI). Currently, the therapeutic applicability of EVE has been changing. Multicenter evaluation of efficacy and safety of everolimus in daily routine and definition of patient characteristics with favorable outcome. Data of 165 patients from 9 oncology institutes in Hungary were analyzed retrospectively. Everolimus therapy was used after one TKI in 10 mg starting dose...
October 13, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29027387/safety-and-efficacy-of-ziagen-abacavir-sulfate-in-hiv-infected-korean-patients
#8
Heawon Ann, Ki Hyon Kim, Hyun Young Choi, Hyun Ha Chang, Sang Hoon Han, Kye Hyung Kim, Jin Soo Lee, Yeon Sook Kim, Kyung Hwa Park, Young Keun Kim, Jang Wook Sohn, Na Ra Yun, Chang Seop Lee, Young Wha Choi, Yil Seob Lee, Shin Woo Kim
BACKGROUND: Abacavir is a widely-used nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus (HIV) infection. Mandatory postmarketing surveillance was conducted in Korea to monitor the safety and evaluate the effectiveness of Ziagen® (abacavir sulfate 300 mg; ViiV Healthcare, Middlesex, UK). MATERIALS AND METHODS: An open-label, multi-center, non-interventional postmarketing surveillance study was conducted from June 2010 to June 2016 to monitor the safety and effectiveness of Ziagen across 12 hospitals in Korea...
September 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29027301/challenges-of-post-authorization-safety-studies-lessons-learned-and-results-of-a-french-study-of-fentanyl-buccal-tablet
#9
REVIEW
Natalie Gavrielov-Yusim, Ilda Bidollari, Sigal Kaplan, Netta Bartov
PURPOSE: Recruiting and retaining participants in real-world studies that collect primary data are challenging. This article illustrates these challenges using a post-authorization safety study (PASS) to assess adverse events (AEs) experienced with fentanyl buccal tablet (FBT) over 3 months of treatment. METHODS: This was an observational, prospective, multicenter study in France conducted over 1 year. The study employed primary data collection in FBT-treated patients and their treating physicians via a site qualification questionnaire and patient log completed by physicians and a questionnaire and pain diary completed by patients...
October 13, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29027097/high-number-of-newly-initiated-direct-oral-anticoagulant-users-switch-to-alternate-anticoagulant-therapy
#10
Beenish S Manzoor, Surrey M Walton, Lisa K Sharp, William L Galanter, Todd A Lee, Edith A Nutescu
Real-world evidence focusing on medication switching patterns amongst direct oral anticoagulant (DOACs) has not been well studied. The objective of this study is to evaluate patterns of prescription switching in non-valvular atrial fibrillation (NVAF) patients initiated on a DOAC and previously naïve to anticoagulation (AC) therapy. Data was obtained from Truven Health MarketScan(®) Commercial and Medicare Supplemental database (2009-2013). AC naïve (those without prior anticoagulant use) NVAF patients initiated on a DOAC, with 6 months of continuous health plan enrollment before and after treatment initiation and maintained on continuous therapy for a minimum of 6 months were included...
October 12, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29027078/dynamic-scheduling-for-veterans-health-administration-patients-using-geospatial-dynamic-overbooking
#11
Stephen Adams, William T Scherer, K Preston White, Jason Payne, Oved Hernandez, Mathew S Gerber, N Peter Whitehead
The Veterans Health Administration (VHA) is plagued by abnormally high no-show and cancellation rates that reduce the productivity and efficiency of its medical outpatient clinics. We address this issue by developing a dynamic scheduling system that utilizes mobile computing via geo-location data to estimate the likelihood of a patient arriving on time for a scheduled appointment. These likelihoods are used to update the clinic's schedule in real time. When a patient's arrival probability falls below a given threshold, the patient's appointment is canceled...
October 12, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29025824/development-of-an-evidence-based-complex-intervention-for-community-rehabilitation-of-patients-with-hip-fracture-using-realist-review-survey-and-focus-groups
#12
Jessica Louise Roberts, Nafees Ud Din, Michelle Williams, Claire A Hawkes, Joanna M Charles, Zoe Hoare, Val Morrison, Swapna Alexander, Andrew Lemmey, Catherine Sackley, Phillipa Logan, Clare Wilkinson, Jo Rycroft-Malone, Nefyn H Williams
OBJECTIVES: To develop an evidence and theory-based complex intervention for improving outcomes in elderly patients following hip fracture. DESIGN: Complex-intervention development (Medical Research Council (MRC) framework phase I) using realist literature review, surveys and focus groups of patients and rehabilitation teams. SETTING: North Wales. PARTICIPANTS: Surveys of therapy managers (n=13), community and hospital-based physiotherapists (n=129) and occupational therapists (n=68) throughout the UK...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025047/the-representativeness-of-eligible-patients-in-type-2-diabetes-trials-a-case-study-using-gist-2-0
#13
Anando Sen, Andrew Goldstein, Shreya Chakrabarti, Ning Shang, Tian Kang, Anil Yaman, Patrick B Ryan, Chunhua Weng
Objective: The population representativeness of a clinical study is influenced by how real-world patients qualify for the study. We analyze the representativeness of eligible patients for multiple type 2 diabetes trials and the relationship between representativeness and other trial characteristics. Methods: Sixty-nine study traits available in the electronic health record data for 2034 patients with type 2 diabetes were used to profile the target patients for type 2 diabetes trials...
September 13, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29024975/comparing-methods-to-address-bias-in-observational-data-statin-use-and-cardiovascular-events-in-a-us-cohort
#14
Paulina Kaiser, Alice M Arnold, David Benkeser, Adina Zeki Al Hazzouri, Calvin H Hirsch, Bruce M Psaty, Michelle C Odden
Background: The theoretical conditions under which causal estimates can be derived from observational data are challenging to achieve in the real world. Applied examples can help elucidate the practical limitations of methods to estimate randomized-controlled trial effects from observational data. Methods: We used six methods with varying design and analytic features to compare the 5-year risk of incident myocardial infarction among statin users and non-users, and used non-cardiovascular mortality as a negative control outcome...
September 8, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024264/deutetrabenazine-for-tardive-dyskinesia-a-systematic-review-of-the-efficacy-and-safety-profile-for-this-newly-approved-novel-medication-what-is-the-number-needed-to-treat-number-needed-to-harm-and-likelihood-to-be-helped-or-harmed
#15
REVIEW
Leslie Citrome
OBJECTIVE: Deutetrabenazine is a deuterated formulation of tetrabenazine. The aim of this systematic review is to describe the efficacy, tolerability and safety of deutetrabenazine for the treatment of tardive dyskinesia (TD). DATA SOURCES: The pivotal registration trials were accessed by querying http://www.ncbi.nlm.nih.gov/pubmed/ and http://www.clinicaltrials.gov, for the search terms 'deutetrabenazine' OR 'SD-809', and by also querying the EMBASE (Elsevier) commercial database for clinical poster abstracts, and by asking the manufacturer for copies of posters presented at congresses...
October 12, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29024038/baseline-lab-parameters-predicting-clinical-outcome-in-melanoma-patients-treated-with-ipilimumab-a-single-center-analysis
#16
Thilo Gambichler, Victoria Brown, Ann-Kathrin Steuke, Lutz Schmitz, Eggert Stockfleth, Laura Susok
BACKGROUND: Overall response rates (ORR) for ipilimumab in advanced melanoma are only about 10%. Hence, it is important to explore biomarkers predicting ipilimumab responders. OBJECTIVE: We aimed to explore biomarkers in order to predict therapy outcome in melanoma patients who have undergone standard ipilimumab therapy in a real-world setting. METHODS: Databases of cutaneous melanoma patients (n = 52) who had received ipilimumab were reviewed and data collected on patient characteristics and diverse lab parameters...
October 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29021129/real-world-treatment-sequences-and-outcomes-among-patients-with-non-small-cell-lung-cancer-resounds-in-the-united-states-study-protocol
#17
Lisa M Hess, David M Kern, Gebra Cuyun Carter, Katherine Winfree, Liya Wang, Angelina Sontag, Ana B Oton
BACKGROUND: Survival outcomes are related to treatment choices in a line of therapy and to treatment sequences across all lines of therapy. OBJECTIVE: The Real-World Treatment Sequences and Outcomes among Patients with NSCLC (RESOUNDS) study is designed to (1) evaluate treatment sequences used for patients who receive at least two lines of therapy for non-small cell lung cancer (NSCLC) in the United States and (2) evaluate patient outcomes in terms of progression-free and overall survival related to treatment sequencing...
October 11, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29021127/fall-detection-in-individuals-with-lower-limb-amputations-using-mobile-phones-machine-learning-enhances-robustness-for-real-world-applications
#18
Nicholas Shawen, Luca Lonini, Chaithanya Krishna Mummidisetty, Ilona Shparii, Mark V Albert, Konrad Kording, Arun Jayaraman
BACKGROUND: Automatically detecting falls with mobile phones provides an opportunity for rapid response to injuries and better knowledge of what precipitated the fall and its consequences. This is beneficial for populations that are prone to falling, such as people with lower limb amputations. Prior studies have focused on fall detection in able-bodied individuals using data from a laboratory setting. Such approaches may provide a limited ability to detect falls in amputees and in real-world scenarios...
October 11, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29020193/generalizing-randomized-clinical-trial-results-implementation-and-challenges-related-to-missing-data-in-the-target-population
#19
Jin-Liern Hong, Michele Jonsson Funk, Robert LoCasale, Sara E Dempster, Stephen R Cole, Michael Webster-Clark, Jessie K Edwards, Til Stürmer
Statins are indicated in patients with elevated high-sensitivity C-reactive protein and normal low-density lipoprotein cholesterol based on the multi-country JUPITER trial (2003-2008) results, but the benefit in real-world populations remains unknown. We sought to generalize JUPITER results to trial-eligible population using the UK Clinical Practice Research Datalink (CPRD) 2001-2014. We multiply imputed missing baseline characteristics for the CPRD population and selected the trial-eligible CPRD population as target population based on observed and imputed values...
August 10, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29019353/hot-news-ready-for-hiv-dual-therapy-new-data-from-international-hiv-aids-society-2017
#20
George A Yendewa, Robert A Salata
The introduction of combination antiretroviral therapy (ART) in the 1990s has fundamentally transformed the landscape of HIV medicine, greatly improved disease morbidity and mortality, and reduced transmission rates across all demographic groups. Central to this success was the idea that to achieve best disease outcomes and minimize the development of drug resistance, at least three antiretroviral agents should be used for HIV treatment. This therapeutic strategy is a core tenet of HIV medicine, backed by incontrovertible scientific evidence, and made easy to deploy by the high compliance levels with once-daily coformulations, which have generally been well tolerated...
October 11, 2017: AIDS Reviews
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