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Cancer and pregnancy

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https://www.readbyqxmd.com/read/28223181/the-effect-of-salpingectomy-on-ovarian-function
#1
REVIEW
Alexander Kotlyar, Julian Gingold, Shirley Shue, Tommaso Falcone
OBJECTIVE: To review the literature concerning the effects of salpingectomy on ovarian function as assessed using measures of ovarian reserve and outcomes from in-vitro fertilization and spontaneous pregnancy cycles. BACKGROUND: Tubal surgery is performed for a variety of indications in gynecology. Salpingectomy is the most aggressive form of tubal surgery and may be performed for potential risk reduction for epithelial ovarian cancer, sterilization, ectopic pregnancy and as a method to enhance fertility in the setting of a hydrosalpinx...
February 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28222037/cancer-during-pregnancy-clinical-characteristics-treatment-outcomes-and-prognosis-for-mothers-and-infants
#2
Katarina Jeremic, Aleksandar Stefanovic, Jelena Dotlic, Sasa Kadija, Olivera Kontic, Miroslava Gojnic, Jelena Jeremic, Vesna Kesic
OBJECTIVE: To assess which obstetrical characteristics and treatment improved outcomes and prognosis of pregnant women with malignancy. METHODS: A prospective study, undertaken between 2005 and 2014, involving 35 pregnant women who were diagnosed with malignant tumors during pregnancy. Patients were followed-up for 1 year after delivery. The pregnancy course and outcome and parameters that could influence the condition of mother and fetus were evaluated. RESULTS: Most malignancies were hematological, diagnosed in the second trimester and treated with combined therapy (surgery/adjuvant) after pregnancy...
February 21, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28221401/s%C3%A3-mre-prognos-f%C3%A3-r-unga-kvinnor-med-br%C3%A3-stcancer-fr%C3%A3-gest%C3%A3-llningar-s%C3%A3-som-fertilitet-och-graviditet-viktiga-att-beakta
#3
Irma Fredriksson, Hanna Fredholm
Breast cancer in young women is uncommon, but the second most frequent cause of death in this age group. Young women with breast cancer have a worse prognosis than middle-aged women, with a higher risk of local recurrence, distant disease and breast cancer death. This can partly be explained by diagnosis at a later stage, and a higher proportion of tumors with unfavourable characteristics. However, in women with tumors of the luminal B subtype, low age remained an independent prognostic factor of DDFS and LRFS after correction for stage, tumor characteristics and treatment...
February 14, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28220257/impact-of-prior-breast-cancer-on-mode-of-delivery-and-pregnancy-associated-disorders-a-retrospective-analysis-of-subsequent-pregnancy-outcomes
#4
Louis Jacob, Matthias Kalder, Birgit Arabin, Karel Kostev
PURPOSE: The aim of this paper is to analyze the impact of prior breast cancer (BC) on mode of delivery and pregnancy-associated disorders. METHODS: A database from 262 German gynecological practices including 289,712 women between the ages of 18 and 45 with documented pregnancies between 2000 and 2014 was used to search for patients with a history of BC up to 10 years prior to pregnancy. A total of 165 patients with a history of BC were found and matched with 165 patients without a history of any cancer (1:1) by age, physician, obesity, and documented referral to a fertility center up to 12 months before the index pregnancy...
February 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28210952/two-dechlorinated-chlordecone-derivatives-formed-by-in-situ-chemical-reduction-are-devoid-of-genotoxicity-and-mutagenicity-and-have-lower-proangiogenic-properties-compared-to-the-parent-compound
#5
Samuel Legeay, Pierre-André Billat, Nicolas Clere, Fabrice Nesslany, Sébastien Bristeau, Sébastien Faure, Christophe Mouvet
Chlordecone (CLD) is a chlorinated hydrocarbon insecticide, now classified as a persistent organic pollutant. Several studies have previously reported that chronic exposure to CLD leads to hepatotoxicity, neurotoxicity, raises early child development and pregnancy complications, and increases the risk of liver and prostate cancer. In situ chemical reduction (ISCR) has been identified as a possible way for the remediation of soils contaminated by CLD. In the present study, the objectives were (i) to evaluate the genotoxicity and the mutagenicity of two CLD metabolites formed by ISCR, CLD-5a-hydro, or CLD-5-hydro (5a- or 5- according to CAS nomenclature; CLD-1Cl) and tri-hydroCLD (CLD-3Cl), and (ii) to explore the angiogenic properties of these molecules...
February 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28209435/contribution-of-equilibrative-nucleoside-transporter-ent-2-to-fluorouracil-transport-in-rat-placental-trophoblast-cells
#6
Akinori Takagi, Tomohiro Nishimura, Tomoya Akashi, Masatoshi Tomi, Emi Nakashima
Fluorouracil is used for treatment of breast cancer even in pregnant women, except during fetal organogenesis. The purpose of this study was to clarify the transport mechanism of fluorouracil at the rat placental barrier. Maternal-to-fetal transfer of [(3)H]fluorouracil in rats at gestational day 19.5 was saturable and much higher than that of [(14)C]sucrose. The uptake of [(3)H]fluorouracil was also saturable in rat placental trophoblast TR-TBT 18d-1 cells, which express both equilibrative nucleoside transporter (ENT) 1 and ENT2...
December 8, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28208154/gestational-diabetes-mellitus-may-be-associated-with-increased-risk-of-breast-cancer
#7
Yong-Moon Mark Park, Katie M O'Brien, Shanshan Zhao, Clarice R Weinberg, Donna D Baird, Dale P Sandler
BACKGROUND: Although a positive association between type 2 diabetes and breast cancer has been reported, an association with gestational diabetes mellitus (GDM) is less clear. METHODS: The Sister Study enroled 50 884 women aged 35-74 years, from 2003 through 2009. Cox proportional hazards models were used to estimate breast cancer risk in relation to GDM. RESULTS: Ever having GDM was not associated with breast cancer overall (hazards ratio (HR)=1...
February 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28204904/high-risk-individuals-perceptions-of-reproductive-genetic-testing-for-cdh1-mutations
#8
Nina Hallowell, Shirlene Badger, Sue Richardson, Carlos Caldas, Richard H Hardwick, Rebecca C Fitzgerald, Julia Lawton
Reproductive genetic testing- PreNatal Diagnosis (PND) and Preimplantation Genetic Diagnosis (PGD)-for CDH1 mutations associated with Hereditary Diffuse Gastric Cancer (HDGC)is available in the UK. This qualitative interview study examined high-risk individuals' (n = 35) views of CDH1 reproductive genetic testing. Interviewees generally regarded reproductive genetic testing as an acceptable form of HDGC risk management. However, some were concerned that their genetic risks required them to plan reproduction and anticipated difficulties communicating this to reproductive partners...
February 15, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28203373/a-silent-skull-metastatic-follicular-thyroid-carcinoma-mimicking-as-a-benign-scalp-tumor-in-a-pregnant-woman
#9
Tsung-Chun Huang, Yu-Kai Cheng, Tsung-Wei Chen, Yung-Chang Hsu, En-Wei Liu, Hsin-Han Chen
: Thyroid cancer with cranial metastasis in a pregnant woman is very rare. In the literature, most cases are diagnosed early from neurogenic signs or symptomatic thyroid gland. Pregnancy also contributes to a hesitation toward early surgical and medical treatments. We reported a scalp tumor in a physically healthy 37-year-old pregnant female with a follicular thyroid carcinoma (FTC) with lung, bone and cranial metastasis in initial presentation. Silent neurogenic and physical examinations make an early diagnosis very challenging...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28199859/structure-of-the-lps-o-chain-from-fusobacterium-nucleatum-strain-10953-containing-sialic-acid
#10
Evgeny Vinogradov, Frank St Michael, Kiyonobu Homma, Ashu Sharma, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. Recently, it has been gaining attention as a potential causative agent for colorectal cancer and is strongly linked with pregnancy complications including pre-term and still births. Little is known about virulence factors of this organism and thus we have initiated studies to examine the bacterial surface glycochemistry. Consistent with a recent paper suggesting that F. nucleatum strain 10593 can synthesize sialic acid, a staining technique identified sialic acid on the bacterial surface...
January 28, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28197717/operative-techniques-and-complications-of-extraction-and-transplantation-of-ovarian-tissue-the-erlangen-experience
#11
Matthia W Beckmann, Ralf Dittrich, Laura Lotz, Patricia G Oppelt, Sebastian Findeklee, Thomas Hildebrandt, Katharina Heusinger, Susanne Cupisti, Andreas Müller
PURPOSE: Extracting ovarian tissue before oncologic therapy and transplanting it afterwards are increasingly being used to preserve fertility in women. This study describes standardized and safe operative procedures, with few complications, and reports the resulting ovarian function and pregnancy rates. METHODS: The standardized operative techniques for removing and transplanting ovarian tissue used at the Erlangen center are: for tissue removal, one-third to half of the tissue from one ovary is excised with scissors, without tissue coagulation; for subsequent transplantation, pieces of ovarian tissue are placed in a retroperitoneal pocket without closure of the pocket...
February 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28192526/correction-pregnancy-outcomes-after-treatment-for-cervical-cancer-precursor-lesions-an-observational-study
#12
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0165276.].
2017: PloS One
https://www.readbyqxmd.com/read/28191695/breast-cancer-in-pregnancy-avoiding-fetal-harm-when-maternal-treatment-is-necessary
#13
Christina N Cordeiro, Mary L Gemignani
The management of breast cancer during pregnancy poses unique challenges and requires a multi-disciplinary approach. In this review, we discuss the treatment of breast cancer in pregnancy and recent updates regarding the safety of surgical and chemotherapeutic treatments, including both oncologic and fetal outcomes. The treatment of breast cancer during pregnancy mirrors that outside of pregnancy, with a few important differences dictated by the balance of maternal versus fetal health. Overall, surgical treatment, neo-adjuvant chemotherapy, and/or adjuvant chemotherapy are feasible in most women during pregnancy...
February 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28185739/breast-cancer-outcomes-after-diagnosis-of-hormone-positive-breast-cancer-and-subsequent-pregnancy-in-the-tamoxifen-era
#14
Lauren Nye, Alfred Rademaker, William J Gradishar
BACKGROUND: Counseling patients regarding the risk of future pregnancy on hormone receptor-positive breast cancer outcomes is difficult because of the minimal data and understanding of pregnancy on the breast environment. PATIENTS AND METHODS: The present retrospective analysis included 32 premenopausal women with a diagnosis of estrogen receptor-positive breast cancer from 2000 to 2010 and subsequent pregnancy within 5 years. The control cohort included 29 women matched for age and stage of breast cancer who had not become pregnant...
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28185271/melanoma-and-pregnancy
#15
REVIEW
Sarah Kym Morton, Adam Park Morton
Melanoma is the most common cancer in women during their reproductive years and kills more young Australians than any other single cancer. Care of women whose pregnancy is complicated by a diagnosis of malignancy is complex. The risk of delaying treatment to the mother, the short-term and long-term risks of premature delivery to the child, and the immediate risks to the foetus and long-term risks to the child of maternal treatment with surgery, radiotherapy or medical therapies must be considered.
February 10, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28179200/laparoscopic-management-of-abdomininal-pregnancy
#16
Francesco Cosentino, Cristiano Rossitto, Luigi Carlo Turco, Salvatore Gueli Alletti, Carmine Vascone, Lavinia Di Meglio, Giovanni Scambia, Mario Malzoni
CASE REPORT OBJECTIVE: To show the surgical management in laparoscopy of a particular localization of an extra-uterine pregnancy misunderstood until 12 week of EG complicated by hemoperitoneum and abortion. BACKGROUND: The prevalence of ectopic pregnancy among women who go to an emergency department with first trimester bleeding, pain, or both ranges from 1 to 16 percent [1]. The most common localization of ectopic pregnancy are the Fallopian tubes while abdominal pregnancy represent at least 1 percent of extra-uterine pregnancies...
February 4, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28170295/after-chemotherapy-treatment-for-maternal-cancer-during-pregnancy-is-breastfeeding-possible
#17
Stephen Stopenski, Anum Aslam, Xinmin Zhang, Elyce Cardonick
OBJECTIVE: To report breastfeeding complaints of women diagnosed with cancer during pregnancy and correlate success with characteristics of their treatment. MATERIALS AND METHODS: This is a prospective cohort study of women diagnosed with cancer during pregnancy who attempted breastfeeding. We surveyed participants about breast engorgement, milk let down, and consistent breast milk production through mailed questionnaires. Treatment details, including the type and number of chemotherapy cycles given during pregnancy and antepartum or postpartum depression, were collected...
February 7, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28164814/environmental-justice-and-underserved-communities
#18
REVIEW
Vincent Morelli, Carol Ziegler, Omotayo Fawibe
Underserved communities suffer from environmental inequities. Gases lead to hypoxia and respiratory compromise, ozone to increased respiratory illnesses and decreased mental acuity, and mercury to prenatal cognitive disabilities and antisocial behaviors. Lead toxicity is associated with developmental delays. Cadmium is linked with cancer. The smaller sizes of air pollution particulate matter are pathogenic and are associated with cardiovascular and pulmonary disease and nervous system disorders. Bisphenol A is being studied for possible links to cancer and pregnancy risks...
March 2017: Primary Care
https://www.readbyqxmd.com/read/28158501/third-european-evidence-based-consensus-on-diagnosis-and-management-of-ulcerative-colitis-part-1-definitions-diagnosis-extra-intestinal-manifestations-pregnancy-cancer-surveillance-surgery-and-ileo-anal-pouch-disorders
#19
Fernando Magro, Paolo Gionchetti, Rami Eliakim, Sandro Ardizzone, Alessandro Armuzzi, Manuel Barreiro-de Acosta, Johan Burisch, Krisztina B Gecse, Ailsa L Hart, Pieter Hindryckx, Cord Langner, Jimmy K Limdi, Gianluca Pellino, Edyta Zagórowicz, Tim Raine, Marcus Harbord, Florian Rieder
No abstract text is available yet for this article.
February 2, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28157643/ratios-of-biochemical-markers-in-peritoneal-fluid-to-those-in-venous-blood-for-the-diagnosis-of-ruptured-tubal-pregnancy-a-prospective-study
#20
Xiao-Lu Zhu, Zhuo-Wei Xue, Yan-Li Xu, Juan Wang, Zhi-Hong Ai, Yin-Cheng Teng
OBJECTIVES: Ectopic pregnancies are among the leading causes of maternal morbidity and mortality in both developed and emerging nations, but tests for early, accurate, and convenient detection are lacking. STUDY DESIGN: Between January 2013 and February 2015, 504 women with tubal pregnancy were prospectively recruited, and their clinical characteristics were recorded. Samples of peritoneal fluid were collected by culdocentesis, and venous blood was drawn from the antecubital vein...
January 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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