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Leukemia and pregnancy

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https://www.readbyqxmd.com/read/28503969/essential-thrombocythemia-a-review-of-the-clinical-features-diagnostic-challenges-and-treatment-modalities-in-the-era-of-molecular-discovery
#1
Sarah Chuzi, Brady L Stein
Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm that is associated with diminished quality of life, thrombohemorrhagic complications, and transformation to myelofibrosis (MF) and acute leukemia (AML). The important recent discoveries of driver mutations, including the calreticulin gene in addition to JAK2 and MPL, have led to a greater understanding of disease pathogenesis and set the stage for the advent of more sophisticated prognostic, diagnostic, and therapeutic strategies. In this paper we summarize recent studies describing the molecular basis of ET...
May 15, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28492120/a-rare-case-of-massive-hepatosplenomegaly-due-to-acute-lymphoblastic-leukemia-in-pregnancy
#2
Ricardo Gonçalves, Ruchika Meel
Acute lymphoblastic leukaemia (ALL) is rarely seen in pregnancy. Massive hepatosplenomegaly as a presentation of ALL has not been described previously in any patient population. A 30-year-old pregnant woman presented at 16 weeks' gestation with epistaxis, jaundice, diffuse abdominal pain and distension, massive hepatosplenomegaly and peripheral oedema. On the basis of blood tests, bone marrow biopsy and imaging, a diagnosis of ALL complicated by massive hepatosplenomegaly with splenic infarctions was made. The patient was referred to oncology for appropriate chemotherapy...
April 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28476196/parental-exposure-to-workplace-carcinogens-and-the-risk-of-development-of%C3%A2-acute-leukemia-in-infants-case-control-study
#3
María Luisa Pérez-Saldivar, Arturo Fajardo-Gutiérrez, José Alfredo Sierra-Ramírez, Nancy Núñez-Villegas, Héctor Pérez-Lorenzana, Elisa María Dorantes-Acosta, Pedro Francisco Román-Zepeda, María Del Carmen Rodríguez-Zepeda, Juana Esther González-Ulivarri, Norma López-Santiago, Sofía Irene Martínez-Silva, Rogelio Paredes-Aguilera, Martha Margarita Velázquez-Aviña, Janet Flores-Lujano, Elva Jiménez-Hernández, Juan Carlos Núñez-Enríquez, Vilma Carolina Bekker-Méndez, Juan Manuel Mejía-Aranguré
BACKGROUND AND AIMS: Occupational exposure of parents to carcinogens is of great interest in the etiology of leukemias. Evidence of the impact of such exposure on infants or small children is scarce. Here we estimated whether occupational exposure of parents to carcinogens could be a risk factor for leukemias in their children. METHODS: Cases of acute leukemia (AL) in infants ≤24 months old diagnosed in Mexico City (1998-2013) were included in a population-based, case-control study...
November 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28476187/early-age-acute-leukemia-revisiting-two-decades-of-the-brazilian-collaborative-study-group
#4
REVIEW
Maria S Pombo-de-Oliveira, Francianne Gomes Andrade
The understanding of leukemogenesis in early-age acute leukemia (EAL) has improved remarkably. Initiating somatic mutations detected in dried neonatal blood spots (DNBS) and in cord blood samples of affected children with leukemia have been proven to be acquired prenatally. However, to date, few epidemiological studies have been carried out exploring EAL that include infants and children 13-24 months of age at the diagnosis. Maternal exposure to transplacental DNA-damaging substances during pregnancy has been suggested to be a risk factor for EAL...
November 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28447764/sevoflurane-anesthesia-in-pregnant-rats-negatively-affects-nerve-function-in-offspring-potentially-via-inhibition-of-the-wnt-%C3%AE-catenin-pathway
#5
Yiyao Wang, Yu Li, Qunzhi Xing, Xuechan G Han, Xu Dong, Yiping Lu, Mintao Zhou
Due to the rapid development of medical technology used to perform intrauterine procedures during pregnancy, the number of patients receiving fetal surgery under general anesthesia is increasing. The aim of the present study was to determine the effects of anesthetics on the offspring of rats, and to identify the potential mechanisms underlying these effects. On day 14 of pregnancy, Sprague‑Dawley rats were equally divided into the following 3 groups (n=9): Control group (n=3), 3% sevoflurane group (n=3) and 4% sevoflurane group (n=3)...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28401353/maternal-fetal-loss-history-and-increased-acute-leukemia-subtype-risk-in-subsequent-offspring-a-systematic-review-and-meta-analysis
#6
REVIEW
M A Karalexi, N Dessypris, A Skalkidou, S -I Biniaris-Georgallis, Ε Ι Kalogirou, T P Thomopoulos, E Herlenius, L G Spector, D Loutradis, G P Chrousos, E Th Petridou
PURPOSE: History of fetal loss including miscarriage and stillbirth has been inconsistently associated with childhood (0-14 years) leukemia in subsequent offspring. A quantitative synthesis of the inconclusive literature by leukemia subtype was therefore conducted. METHODS: Eligible studies (N = 32) were identified through the screening of over 3500 publications. Random-effects meta-analyses were conducted on the association of miscarriage/stillbirth history with overall (AL; 18,868 cases/35,685 controls), acute lymphoblastic (ALL; 16,150 cases/38,655 controls), and myeloid (AML; 3042 cases/32,997 controls) leukemia...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28383372/maternal-fetal-and-neonatal-imatinib-levels-with-treatment-of-chronic-myeloid-leukemia-in-pregnancy
#7
Richard M Burwick, Kelly Kuo, Diana Brewer, Brian J Druker
BACKGROUND: Pregnant women with chronic myeloid leukemia (CML) can be treated effectively with the tyrosine-kinase inhibitor imatinib, but data regarding fetal and neonatal exposure and safety are limited. CASE: We present a patient with newly diagnosed CML in early pregnancy. Leukapheresis and interferon-α were initiated in the second trimester with limited benefit. Imatinib was subsequently started at 28 weeks of gestation with complete hematologic response within 4 weeks...
May 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28379884/parental-alcohol-consumption-and-risk-of-leukemia-in-the-offspring-a-systematic-review-and-meta-analysis
#8
Maria A Karalexi, Nick Dessypris, Thomas P Thomopoulos, Evangelos Ntouvelis, Maria Kantzanou, Andreas-Antonios Diamantaras, Maria Moschovi, Margarita Baka, Emmanuel Hatzipantelis, Maria Kourti, Sophia Polychronopoulou, Eftichia Stiakaki, Ana-M Mora, Victor Wunsch-Filho, Claire Infante-Rivard, Dimitrios Loutradis, Eleni Th Petridou
Parental alcohol consumption before and during pregnancy has been linked to adverse outcomes in the offspring including leukemogenesis. We, therefore, aimed to systematically assess and quantitatively synthesize published data on the association of paternal consumption during preconception and maternal consumption during pregnancy with leukemia risk in childhood (0-14 years). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched PubMed (until February 2016) and the reference lists of the relevant studies...
April 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28319818/a-task-based-assessment-of-parental-occupational-exposure-to-pesticides-and-childhood-acute-lymphoblastic-leukemia
#9
Robert B Gunier, Alice Kang, S Katharine Hammond, Kyndaron Reinier, C Suzanne Lea, Jeffrey S Chang, Monique Does, Ghislaine Scelo, Janice Kirsch, Vonda Crouse, Robert Cooper, Patricia Quinlan, Catherine Metayer
OBJECTIVES: Associations between parental occupational pesticide exposure and childhood acute lymphoblastic leukemia (ALL) vary across studies, likely due to different exposure assessment methodologies. METHODS: We assessed parental occupational pesticide exposure from the year before pregnancy to the child's third year of life for 669 children diagnosed with ALL and 1021 controls. We conducted expert rating using task-based job modules (JM) to estimate exposure to pesticides among farmer workers, gardeners, agricultural packers, and pesticide applicators...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28288025/coffee-and-cancer-risk-a-summary-overview
#10
Gianfranco Alicandro, Alessandra Tavani, Carlo La Vecchia
We reviewed available evidence on coffee drinking and the risk of all cancers and selected cancers updated to May 2016. Coffee consumption is not associated with overall cancer risk. A meta-analysis reported a pooled relative risk (RR) for an increment of 1 cup of coffee/day of 1.00 [95% confidence interval (CI): 0.99-1.01] for all cancers. Coffee drinking is associated with a reduced risk of liver cancer. A meta-analysis of cohort studies found an RR for an increment of consumption of 1 cup/day of 0.85 (95% CI: 0...
March 10, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28275540/a-rare-breed-wild-type-braf-and-ighv-expression-in-a-29-year-old-lady-with-classical-hairy-cell-leukemia
#11
Aneesha Hossain, Hind Rafei, Amar Jariwala, Khaled El-Shami
The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy.
2017: Leukemia Research Reports
https://www.readbyqxmd.com/read/28256509/customized-laboratory-tlr4-and-tlr2-detection-method-from-peripheral-human-blood-for-early-detection-of-doxorubicin-induced-cardiotoxicity
#12
A L Pop-Moldovan, N-M Trofenciuc, D A Dărăbanţiu, C Precup, H Branea, R Christodorescu, M Puşchiţă
Cancer treatments can have significant cardiovascular adverse effects that can cause cardiomyopathy and heart failure with reduced survival benefit and considerable decrease in the use of antineoplastic therapy. The purpose of this study is to assess the role of TLR2 and TLR4 gene expression as an early marker for the risk of doxorubicin-induced cardiomyopathy in correlation with early diastolic dysfunction in patients treated with doxorubicin. Our study included 25 consecutive patients who received treatment with doxorubicin for hematological malignancies (leukemia, lymphomas or multiple myeloma), aged 18-65 years, with a survival probability>6 months and with left ventricular ejection fraction>50%...
May 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28255764/erratum-to-pregnancy-outcome-among-partners-of-male-patients-receiving-imatinib-dasatinib-or-nilotinib-in-chronic-myeloid-leukemia-reports-collected-by-the-french-network-pharmacovigilance-centers
#13
Patrick Carlier, Maritza Markarian, Nathalie Bernard, Laurence Lagarce, Anne Dautriche, Johanna Béné, Nathalie Fouilhe Sam-Lai, Pirayeh Eftekhari
No abstract text is available yet for this article.
April 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28230720/role-of-vitamin-a-retinoic-acid-in-regulation-of-embryonic-and-adult-hematopoiesis
#14
REVIEW
Ana Cañete, Elena Cano, Ramón Muñoz-Chápuli, Rita Carmona
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality...
February 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28202519/correlates-of-prenatal-and-early-life-tobacco-smoke-exposure-and-frequency-of-common-gene-deletions-in-childhood-acute-lymphoblastic-leukemia
#15
Adam J de Smith, Maneet Kaur, Semira Gonseth, Alyson Endicott, Steve Selvin, Luoping Zhang, Ritu Roy, Xiaorong Shao, Helen M Hansen, Alice Y Kang, Kyle M Walsh, Gary V Dahl, Roberta McKean-Cowdin, Catherine Metayer, Joseph L Wiemels
Tobacco smoke exposure has been associated with risk of childhood acute lymphoblastic leukemia (ALL). Understanding the relationship between tobacco exposures and specific mutations may yield etiologic insights. We carried out a case-only analysis to explore whether prenatal and early-life tobacco smoke exposure influences the formation of leukemogenic genomic deletions. Somatic copy number of 8 genes frequently deleted in ALL (CDKN2A, ETV6, IKZF1, PAX5, RB1, BTG1, PAR1 region, and EBF1) was assessed in 559 pretreatment tumor samples from the California Childhood Leukemia Study...
April 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28144455/breastfeeding-as-a-protective-effect-against-childhood-leukemia-and-lymphoma
#16
Mehran Karimi, Mahmoud Haghighat, Zahra Dialameh, Leila Tahmasbi, Shirin Parand, Marzieh Bardestani
BACKGROUND: Over the past several years, breastfeeding has been associated with many benefits as well as protective effects against many diseases. There is limited evidence for the relationship between breastfeeding and the incidence of leukemia. OBJECTIVES: In this study, we evaluate the correlation of childhood leukemia and lymphoma with breastfeeding duration in children in southern Iran. PATIENTS AND METHODS: Through this case control study, we compared 123 patients with leukemia and lymphoma to a control group of 137 healthy children...
September 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28130996/association-of-maternal-and-index-child-s-diet-with-subsequent-leukemia-risk-a-systematic-review-and-meta-analysis
#17
REVIEW
Nick Dessypris, Maria A Karalexi, Evangelos Ntouvelis, Andreas-Antonios Diamantaras, Vassilios Papadakis, Margarita Baka, Emmanuel Hatzipantelis, Maria Kourti, Maria Moschovi, Sophia Polychronopoulou, Vasiliki Sidi, Eftichia Stiakaki, Eleni Th Petridou
BACKGROUND: Exploring the effect of maternal and/or childhood diet on offspring leukemogenesis is challenging, given differences in food group categories, their potentially variable impact depending on time window of exposure and the multiple leukemia subtypes. We opted to quantitatively synthesize published data on the association of maternal/child diet with leukemia risk. METHODS: Medline was searched until June 30th, 2016 for eligible articles on the association of childhood leukemia with consumption of (i) food groups, excluding alcoholic and non-alcoholic beverages, and (ii) specific dietary supplements before/during index pregnancy and childhood...
April 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28108116/maternal-exposure-to-ambient-air-pollution-and-risk-of-early-childhood-cancers-a-population-based-study-in-ontario-canada
#18
Éric Lavigne, Marc-André Bélair, Minh T Do, David M Stieb, Perry Hystad, Aaron van Donkelaar, Randall V Martin, Daniel L Crouse, Eric Crighton, Hong Chen, Jeffrey R Brook, Richard T Burnett, Scott Weichenthal, Paul J Villeneuve, Teresa To, Sabit Cakmak, Markey Johnson, Abdool S Yasseen, Kenneth C Johnson, Marianna Ofner, Lin Xie, Mark Walker
BACKGROUND: There are increasing concerns regarding the role of exposure to ambient air pollution during pregnancy in the development of early childhood cancers. OBJECTIVE: This population based study examined whether prenatal and early life (<1year of age) exposures to ambient air pollutants, including nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters ≤2.5μm (PM2.5), were associated with selected common early childhood cancers in Canada...
January 17, 2017: Environment International
https://www.readbyqxmd.com/read/28092993/do-all-patients-with-chronic-myeloid-leukemia-need-to-receive-interferon-during-pregnancy
#19
Ahmet Emre Eskazan
No abstract text is available yet for this article.
August 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28091415/advances-of-coagulation-factor-xiii
#20
REVIEW
Da-Yu Shi, Shu-Jie Wang
OBJECTIVE: To provide a comprehensive literature review on roles of coagulation factor XIII (FXIII) in coagulation, wound healing, neoplasm, bone metabolism, and pregnancy. DATA SOURCES: All articles in PubMed with key words "Coagulation factor XIII", "wound", "leukemia", "tumor", "bone," and "pregnancy" with published date from 2001 to 2016 were included in the study. Frequently cited publications before 2000 were also included. STUDY SELECTION: We reviewed the role of FXIII in biologic processes as documented in clinical, animal, and in vitro studies...
January 20, 2017: Chinese Medical Journal
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