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Leukemia and pregnancy

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https://www.readbyqxmd.com/read/27861356/a-childhood-acute-lymphoblastic-leukemia-genome-wide-association-study-identifies-novel-sex-specific-risk-variants
#1
Sandeep K Singh, Philip J Lupo, Michael E Scheurer, Anshul Saxena, Amy E Kennedy, Boubakari Ibrahimou, Manuel Alejandro Barbieri, Ken I Mills, Jacob L McCauley, Mehmet Fatih Okcu, Mehmet Tevfik Dorak
Childhood acute lymphoblastic leukemia (ALL) occurs more frequently in males. Reasons behind sex differences in childhood ALL risk are unknown. In the present genome-wide association study (GWAS), we explored the genetic basis of sex differences by comparing genotype frequencies between male and female cases in a case-only study to assess effect-modification by sex.The case-only design included 236 incident cases of childhood ALL consecutively recruited at the Texas Children's Cancer Center in Houston, Texas from 2007 to 2012...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27824869/maternal-smoking-and-the-risk-of-cancer-in-early-life-a-meta-analysis
#2
Isabell Katharina Rumrich, Matti Viluksela, Kirsi Vähäkangas, Mika Gissler, Heljä-Marja Surcel, Otto Hänninen
BACKGROUND: In spite of the well-known harmful effects on the fetus, many women continue smoking during pregnancy. Smoking as an important source of toxic chemicals may contribute to the developmental origin of diseases. OBJECTIVES: The aim of this work was to pursue the possible association between maternal smoking and cancer in early life. Specifically, we wanted to identify the associated early life cancer types, and to quantify the associations. METHODS: In a systematic literature search 825 articles were identified in PubMed and Web of Science, and 55 more through the reference lists...
2016: PloS One
https://www.readbyqxmd.com/read/27765136/-association-between-parental-exposure-to-environmental-risk-factors-and-the-risk-of-childhood-acute-lymphoblastic-leukemia
#3
J W Zhang, Q Zeng, L Zhao, M Zhang, L Zhang, Q Gu
Objective: To investigate the association between parental environmental risk factors exposure and the risk for childhood acute lymphoblastic leukemia (ALL). Methods: A total of 179 ALL children cases were selected in Tianjin Blood Disease Hospital and 136 healthy children matched by age, gender and living place were selected in 2015 for a case control study. The data were analyzed with univariate and multivariate non conditional logistic regression models. Results: The results of multivariate logistic regression analysis indicated that sex, history of abortion, exposure in a smoking environment during pregnancy, catching a cold, taking antipyretic analgesics, maternal exposure to air purifying agent, father' s occupational exposure to petroleum products and home decoration during pregnancy were associated with the risk of childhood ALL (P<0...
October 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27697774/haploidentical-hematopoietic-transplantation-for-the-cure-of-leukemia-from-its-biology-to-clinical-translation
#4
Antonella Mancusi, Loredana Ruggeri, Andrea Velardi
The present review describes the biology of human leukocyte antigen (HLA) haplotype mismatched ("haploidentical") transplantation, its translation to clinical practice to cure leukemia and the results of current transplantation protocols. The 1990s saw what had been major drawbacks of haploidentical transplantation, i.e., very strong host-versus-graft and graft-versus-host alloresponses which led respectively to rejection and graft-versus-host disease (GVHD), being overcome through transplantation of a "mega-dose" of T cell-depleted peripheral blood hematopoietic progenitor cells and no posttransplant pharmacological immunosuppression...
October 3, 2016: Blood
https://www.readbyqxmd.com/read/27686768/-association-of-exposure-to-environmental-chemicals-with-risk-of-childhood-acute-lymphocytic-leukemia
#5
W C Jiang, S Y Wu, Y B Ke
Objective: This study aimed to investigate the association between exposure to environmental chemicals and the risk of childhood acute lymphocytic leukemia(cALL). Methods: A case-controlled study was conducted in Shenzhen Children's Hospital, China from January 2015 to January 2016. The cases were selected from the section of Hematology and Oncology, and the controls were selected from Orthopedics by 1∶2 matching of cases according to sex and age. A questionnaire including population data and chemical exposure characteristics was conducted on the children's parents, and urine and EDTA-blood were collected from the children...
October 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27618636/low-rates-of-pregnancy-screening-in-adolescents-before-teratogenic-exposures-in-a-national-sample-of-children-s-hospitals
#6
Pooja Rao, Yimei Li, Kelly D Getz, Tamara P Miller, Yuan-Shung Huang, Jennifer J Wilkes, Alix E Seif, Rochelle Bagatell, Brian T Fisher, Clarisa Gracia, Richard Aplenc
BACKGROUND: Adolescents with cancer engage in sexual behaviors and are exposed to teratogenic chemotherapy. There are no data regarding pregnancy screening patterns for adolescents before chemotherapy exposure. METHODS: A cross-sectional study of leukemia and emergency room (ER) admissions in the Pediatric Health Information System from 1999 to 2011 was conducted. Females who were 10 to 18 years old and 1) had newly diagnosed acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) or 2) had ER visits with computed tomography (CT) of the abdomen/pelvis were included...
September 12, 2016: Cancer
https://www.readbyqxmd.com/read/27613707/maternal-pre-pregnancy-and-gestational-diabetes-obesity-gestational-weight-gain-and-risk-of-cancer-in-young-children-a-population-based-study-in-california
#7
Zuelma A Contreras, Beate Ritz, Jasveer Virk, Myles Cockburn, Julia E Heck
PURPOSE: We aimed to examine the influence of pre-pregnancy diabetes, pre-pregnancy body mass index (BMI), gestational diabetes, and gestational weight gain on childhood cancer risk in offspring. METHODS: We identified cancer cases (n = 11,149) younger than age 6 years at diagnosis from the California Cancer Registry registered between 1988 and 2013. Controls (n = 270,147) were randomly sampled from California birth records, and frequency matched by year of birth to all childhood cancers during the study period...
October 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27562703/water-extracted-perilla-frutescens-increases-endometrial-receptivity-though-leukemia-inhibitory-factor-dependent-expression-of-integrins
#8
Eun-Yeong Kim, Hee-Jung Choi, Tae-Wook Chung, Jun-Yong Choi, Hyung Sik Kim, Yeon-Seop Jung, Syng-Ook Lee, Ki-Tae Ha
The leaves and stems of Perilla frutescens var. acuta Kudo (PF) have been used to prevent threatened abortion in traditional medicine in the East Asian countries. Because reduced receptivity of endometrium is a cause of abortion, we analyzed the action of PF on the endometrial receptivity. PF increased the level of leukemia inhibitory factor (LIF), a major cytokine regulating endometrial receptivity, and LIF receptor in human endometrial Ishikawa cells. The PF-induced LIF expression was mediated by c-jun N-terminal kinase (JNK) and p38 pathways...
August 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27562538/acute-leukemia-in-pregnancy-a-single-institution-experience-with-23-patients
#9
Nosha Farhadfar, Sonia Cerquozzi, Michael R Hessenauer, Mark R Litzow, William J Hogan, Louis Letendre, Mrinal M Patnaik, Ayalew Tefferi, Naseema Gangat
Management of acute leukemia during pregnancy presents a considerable challenge. Herein, we review our experience of 23 patients diagnosed with acute leukemia; during pregnancy at the Mayo Clinic between 1962 and 2016. Ten (43.4%), seven (30.4%), and six (26.2%) patients were diagnosed in first, second, and third trimester, respectively. In approximately, 50% (n = 11) therapeutic terminations or spontaneous abortions occurred. Fifty percent (2/4) of patients diagnosed during either first or second trimester who delayed chemotherapy by greater than one week died during induction therapy...
August 26, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27499223/immunological-complications-of-blood-transfusions
#10
Anneke Brand
Most adverse blood transfusion (BT) events are immune-mediated and in the majority of severe reactions antibodies can be identified as causal factors. Alloimmunization not only causes symptomatic reactions, transfused cells can also be (silently) destroyed. Immunization by BT can contribute to hemolytic disease of the newborn as well as to allograft rejection after transplantation. Reversely, pregnancy and transplantation may evoke immunity hampering transfusion therapy. Besides causing mortality and morbidity, alloimmunization has a huge economic impact...
July 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27492895/parental-tobacco-smoking-and-acute-myeloid-leukemia-the-childhood-leukemia-international-consortium
#11
Catherine Metayer, Eleni Petridou, Juan Manuel Mejía Aranguré, Eve Roman, Joachim Schüz, Corrado Magnani, Ana Maria Mora, Beth A Mueller, Maria S Pombo de Oliveira, John D Dockerty, Kathryn McCauley, Tracy Lightfoot, Emmanouel Hatzipantelis, Jérémie Rudant, Janet Flores-Lujano, Peter Kaatsch, Lucia Miligi, Catharina Wesseling, David R Doody, Maria Moschovi, Laurent Orsi, Stefano Mattioli, Steve Selvin, Alice Y Kang, Jacqueline Clavel
The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age <15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2...
August 15, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27472187/effects-of-maternal-diet-during-pregnancy-on-the-risk-of-childhood-acute-lymphoblastic-leukemia-a-systematic-review
#12
Behnaz Abiri, Roya Kelishadi, Homa Sadeghi, Fatemeh Azizi-Soleiman
Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children that can be affected by maternal diet. The aim of this study was to evaluate maternal dietary risk factors of ALL. We searched MEDLINE, Cochrane Library, Springer Link, Wiley Online, Science Direct, Mosby, ISI Web of Science, OVID, ProQuest, and Scopus from database inception until February 2, 2016. Two reviewers scanned titles, abstracts, and keywords of articles after excluding duplicates. We included case-control studies evaluating the relationship between maternal diet during pregnancy and childhood ALL...
October 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27443101/-tumor-lysis-syndrome-in-a-pregnancy-complicated-with-acute-lymphoblastic-leukemia
#13
M P Álvarez-Goris, R Sánchez-Zamora, A A Torres-Aguilar, J C Briones Garduño
Acute leukemia is rare during pregnancy, affects about 1 in 75,000 pregnancies, of all leukemias diagnosed only 28% are acute lymphoblastic leukemia, this is a risk factor to develop spontaneous tumor lysis syndrome, it's a oncologic complication potentially deadly if the prophylactic treatment its avoided. Cases of acute lymphoblastic leukemia associated with pregnancy has been poorly documented in the literature the association of these two entities to pregnancy is the first report published worldwide, so the information is limited...
April 2016: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/27408762/hematologic-malignancies-during-pregnancy-a-review
#14
REVIEW
Hossam K Mahmoud, Mohamed A Samra, Gamal M Fathy
Malignancy is the second most common cause of mortality in the reproductive period and it complicates up to one out of every 1000 pregnancies. When cancer is diagnosed during pregnancy, the management approach must take into consideration both the mother and her fetus. Hematologic cancers diagnosed in pregnancy are not common, resulting in paucity of randomized controlled trials. Diagnosis of such malignancies may be missed or delayed, as their symptoms are similar to those encountered during normal pregnancy...
July 2016: Journal of Advanced Research
https://www.readbyqxmd.com/read/27402672/maternal-iron-status-during-pregnancy-compared-with-neonatal-iron-status-better-predicts-placental-iron-transporter-expression-in-humans
#15
Cora M Best, Eva K Pressman, Chang Cao, Elizabeth Cooper, Ronnie Guillet, Olivia L Yost, Jonathan Galati, Tera R Kent, Kimberly O O'Brien
The placenta richly expresses nonheme and heme Fe transport proteins. To address the impact of maternal and neonatal Fe status and hepcidin on the regulation of these proteins, mRNA expression and protein abundance of nonheme and heme Fe transport proteins were evaluated in placental tissue from 154 adolescents. Regression analyses found maternal Fe status was significantly associated with multiple placental nonheme and heme transporters, whereas neonatal Fe status was related to only 3 heme transporters. Across statistical analyses, maternal Fe status was consistently associated with the placental nonheme Fe importer transferrin receptor 1 (TfR1)...
July 11, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27399778/cells-deficient-in-the-fanconi-anemia-protein-fancd2-are-hypersensitive-to-the-cytotoxicity-and-dna-damage-induced-by-coffee-and-caffeic-acid
#16
Estefanía Burgos-Morón, José Manuel Calderón-Montaño, Manuel Luis Orta, Emilio Guillén-Mancina, Santiago Mateos, Miguel López-Lázaro
Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular disorders, some cancers, diabetes, Parkinson and Alzheimer disease. Coffee consumption, however, has also been linked to an increased risk of developing some types of cancer, including bladder cancer in adults and leukemia in children of mothers who drink coffee during pregnancy. Since cancer is driven by the accumulation of DNA alterations, the ability of the coffee constituent caffeic acid to induce DNA damage in cells may play a role in the carcinogenic potential of this beverage...
2016: Toxins
https://www.readbyqxmd.com/read/27389610/prevention-of-vitamin-k-deficiency-bleeding
#17
Julia C Phillippi, Sharon L Holley, Anna Morad, Michelle R Collins
The risk that a newborn will develop vitamin K deficiency bleeding is 1700/100,000 (one out of 59) if vitamin K is not administered. When intramuscular vitamin K is administered, the risk of vitamin K deficiency bleeding is reduced to 1/100,000. While women may have misconceptions about vitamin K prophylaxis for their newborns, health care providers should be prepared with factual information. Prophylaxis is needed even for healthy newborns without risk factors for bleeding. Other forms of vitamin K supplementation, including oral administration of Food and Drug Administration-approved vitamin K preparations and maternal supplements during pregnancy or lactation, do not have the same effectiveness as the parenteral form...
July 7, 2016: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/27389567/pregnancy-part-of-life-in-chronic-myelogenous-leukemia
#18
Arjun Datt Law, Dennis Dong Hwan Kim, Jeffrey Howard Lipton
Management of pregnant patients with chronic myelogenous leukemia (CML) is challenging. Some of the factors that need to be considered include stage of pregnancy, disease status, and degree of drug exposure. Managing a patient who has been diagnosed while pregnant requires a different approach as compared with a patient who becomes pregnant while on the treatment with a tyrosine kinase inhibitor (TKI). Younger patients may wish to conceive while on treatment and need a more personalized treatment plan based on the degree and duration of their molecular status...
July 7, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27352939/management-of-pregnant-chronic-myeloid%C3%A2-leukemia-patients
#19
Elisabetta Abruzzese, Malgorzata Monika Trawinska, Paolo de Fabritiis, Michele Baccarani
INTRODUCTION: Since the introduction of tyrosine kinase inhibitors (TKIs) therapy, chronic myeloid leukemia (CML), has moved from a fatal illness to a manageable disease with a possible normal lifespan. For this reason is more and more frequent that younger patients address the possibility to conceive, if men, or get pregnant, if women. Knowledge of safety and risks concerning both patient and progeny, as well as important cultural, ethical and psychosocial issues must be taken into consideration...
August 2016: Expert Review of Hematology
https://www.readbyqxmd.com/read/27343314/immunohistochemical-and-ultrastructural-analysis-of-the-effect-of-omega-3-on-embryonic-implantation-in-an-experimental-mouse-model
#20
Kemal Sarsmaz, Asli Goker, Serap Cilaker Micili, Bekir Ugur Ergur, Naci Kemal Kuscu
OBJECTIVE: Implantation is the first step to a healthy pregnancy. Omega-3 supplementation is common to use during pregnancy, for its antioxidant and membrane stabilising effect. In this study we have aimed to study the effect of Omega-3 supplementation on implantation in a mouse model by immunohistochemical methods and electron microscopic evaluation. MATERIALS AND METHODS: Mice were randomized into three groups to receive standard food, Omega-3 400 mg/kg and Omega-3 1000 mg/kg one menstrual cycle before mating...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
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