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Acute myelogenous leukemia and pregnancy

Dror Meirow, Hila Ra'anani, Moran Shapira, Masha Brenghausen, Sanaz Derech Chaim, Sarit Aviel-Ronen, Ninette Amariglio, Eyal Schiff, Raoul Orvieto, Jehoshua Dor
OBJECTIVE: To report the single-center results of orthotopic retransplantations of cryopreserved ovarian tissue in cancer survivors and evaluate the validity of commonly accepted procedure limitations. DESIGN: Prospective cohort study. SETTING: Tertiary university-affiliated assisted reproduction technology (ART) and oncology centers. PATIENT(S): Twenty cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue with the aim to conceive...
August 2016: Fertility and Sterility
Piyush G Limdiwala, Shilpa J Parikh, Jigna S Shah
Acute febrile neutrophilic dermatosis or Sweet's syndrome (SS) is characterized by painful, erythematous plaques of rapid onset accompanied by fever. The etiology of SS is unknown and it may be associated with antecedent infections, malignancies, autoimmune diseases, drugs and vaccines, upper respiratory or gastrointestinal infection, pregnancy, inflammatory bowel disease as well as chemotherapy or idiopathic. The standard therapy for SS is systemic corticosteroids. We report a rare case of 19-year-old young male patient with complaint of severe ill-defined type of pain in both jaws associated with plaques and papules on extensor surfaces of upper and lower extremities with bodyache and myalgia...
May 2014: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
M Karimi-Zarchi, M Ghane Ezabadi, S Hekmatimoghaddam, M Mortazavizade, S Taghipour, M Vahidfar, H Vahedian, M Forat, F Shamsi, A Miratashi-Yazdi
INTRODUCTION: Although occurrence of cancer during pregnancy is rare, it leads to high morbidity and mortality in both mother and fetus. Recent trends in prolongation of child-bearing age have made cancer-associated pregnancies more frequent than past. As yet there are few documents concerning cancer and its related treatment outcomes during pregnancy. This study aimed at describing clinical characteristics of pregnant women with cancer in the Shahid Sadoughi hospital in Yazd, Iran. MATERIALS AND METHODS: Case series were reviewed retrospectively, which included 19 pregnant women diagnosed with cancer in Shahid Sadoughi hospital from 2002 to 2012...
September 2013: International Journal of Biomedical Science: IJBS
Hacer Ergin, Özmert M A Özdemir, Abdullah Karaca, Nilay Şen Türk, Füsun Düzcan, Şeniz Ergin, Elif Kazancı, Canan Vergin, Ayşe Erbay
Congenital leukemia is a rare disease. The majority of cases of this disease are acute myelogenous leukemia (AML). Congenital acute lymphoblastic leukemia (ALL) is rare and most often is of B cell lineage. Rarely, some cases have been designated biphenotypic or mixed phenotype acute leukemia (MPAL). Herein, we report a preterm newborn referred to us as a result of the appearance of blue-violaceous dermal nodules on her body at birth. She was a twin and the product of an in vitro fertilization (IVF) pregnancy...
August 2015: Pediatrics and Neonatology
Yuri Uchiyama, Takumi Hoshino, Masahiro Mihara, Takeki Mitsui, Hiromi Koiso, Makiko Takizawa, Akihiko Yokohama, Takayuki Saitoh, Hideki Uchiumi, Hiroshi Handa, Norifumi Tsukamoto, Hirokazu Murakami, Yoshihisa Nojima
A 45-year-old woman with acute myelogenous leukemia developed platelet transfusion refractoriness (PTR) after the engraftment of an allogeneic peripheral blood stem cell transplantation (PBSCT) from her multiparous sister, which was attributed to HLA antibodies that could not be detected in the patient's serum before transplantation. She achieved neutrophil engraftment by day 18 and megakaryocytopoiesis and complete donor chimerism was confirmed in the bone marrow on day 21. IgG-class HLA antibodies were detected in her serum on day 24 after PBSCT; however, on day 15, no HLA antibodies were detected...
February 2013: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
S Regragui, S Amelal, S Astati, M Zine, N Alami Drideb, A Al Bouzidi, N Messaoudi, M Benkirane, K Doghmi, M Mikdame
The thrombotic microangiopathy is a syndrome characterized by the combination of mechanical hemolytic anemia, peripheral thrombocytopenia, and organ failure of variable severity. In addition to the idiopathic form, several cases are identified as secondary to pregnancy, infections, disease systems, organ transplants, and cancer. Other forms are secondary to drugs including antimitotics. We report the case of a patient followed for acute myelogenous leukemia. She received induction chemotherapy combining daunorubicin and cytarabine, complicated by thrombotic thrombocytopenic purpura...
2012: Case Reports in Hematology
Ami J Shah
The number of patients who have had successful pregnancies following hematopoietic stem cell transplant during childhood remains under investigation. As the number of survivors increase and enter adulthood, we continue to learn more about fertility in these patients. In this case report we report the case of a 27 year-old female who had a normal full term delivery 19 years following a myeloablative autologous transplant for relapsed acute myelogenous leukemia.
July 2011: Journal of Pediatric Hematology/oncology
Haruko Tashiro, Koichi Umezawa, Michihiko Shirota, Yoko Oka, Ryosuke Shirasaki, Ryuichi Nishi, Akinori Taguchi, Nobu Akiyama, Kazuo Kawasugi, Takuya Ayabe, Naoki Shirafuji
We report here a 35-year-old pregnant woman with acute myelogenous leukemia (AML). She was diagnosed with AML (M2) in August 2009, coinciding with the 26(th) week of pregnancy. She underwent a cesarean section at 27 weeks gestation, delivering a very low birth weight male infant (1,066 g). One week later, she received induction chemotherapy with idarubicin and cytarabine. She achieved complete remission after two courses of chemotherapy. The incidence of acute leukemia during pregnancy is low. Chemotherapy after the 2(nd) trimester is not associated with an increased rate of fetal malformation...
January 2011: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Sherrill J Slichter, Douglas Bolgiano, Kuo-Jang Kao, Thomas S Kickler, Janice McFarland, Jeffrey McCullough, Robert Woodson
Patients with acute myelogenous leukemia undergoing induction chemotherapy have significant decreases in alloimmune platelet refractoriness if they receive filter-leukoreduced or UV-B-irradiated vs standard platelet transfusions (3%-5% vs 13%, respectively; P ≤ .03) with no differences among the treated platelet arms (Trial to Reduce Alloimmunization to Platelets). Therefore, measuring antibody persistence might identify the best platelets for transfusion. Lymphocytotoxic (LCT) antibody duration was evaluated for association with patient age, sex, prior transfusion and pregnancy history, study-assigned platelet transfusions, and percentage LCT panel reactive antibodies...
April 2011: Transfusion Medicine Reviews
Mariam Sampson, Anthony E Archibong, Adriane Powell, Brandon Strange, Shannon Roberson, Edward R Hills, Phillip Bourne
Women are advised not to attempt pregnancy while on hydroxyurea (HU) due to the teratogenic effects of this agent, based on results obtained from animal studies. Several case reports suggest that HU may have minimal or no teratogenic effects on the developing human fetus. Fourteen cases of HU therapy in pregnant patients diagnosed with acute or chronic myelogenous leukemia, primary thrombocythemia, or sickle cell disease (SCD) have been reported. Three pregnancies were terminated by elective abortion; 1 woman developed eclampsia and delivered a phenotypically normal stillborn infant...
May 2010: International Journal of Environmental Research and Public Health
Eleni Katzaki, Gilles Morin, Marzia Pollazzon, Filomena Tiziana Papa, Sabrina Buoni, Joussef Hayek, Joris Andrieux, Laure Lecerf, Cornel Popovici, Aline Receveur, Michèle Mathieu-Dramard, Alessandra Renieri, Francesca Mari, Nicole Philip
During the last few years, an increasing number of microdeletion/microduplication syndromes have been delineated. This rapid evolution is mainly due to the availability of microarray technology as a routine diagnostic tool. Microdeletions of the 21q22.11q22.12 region encompassing the RUNX1 gene have been reported in nine patients presenting with syndromic thrombocytopenia and mental retardation. RUNX1 gene is responsible for an autosomal dominant platelet disorder with predisposition to acute myelogenous leukemia...
July 2010: American Journal of Medical Genetics. Part A
Shahid Raza, Khalil Ullah, Parvez Ahmed, Badshah Khan, Muhammad Khalid Kamal
OBJECTIVE: To determine post-transplant survival in chronic myeloid leukaemia patients undergoing allogeneic stem cell transplant. STUDY DESIGN: Longitudinal, descriptive study. PLACE AND DURATION OF STUDY: Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan, between April 2002 and August 2007. METHODOLOGY: All patients of chronic myeloid leukaemia in chronic phase having HLA identical donor and age under 55 years, normal hepatic, renal and cardiac functions with good performance status were selected...
October 2008: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Pascale Cony-Makhoul, Anne Bergeron, Sélim Corm, Viviane Dubruille, Delphine Rea, Françoise Rigal-Huguet, Franck Emmanuel Nicolini
Dasatinib (Sprycel) is a new-targeted therapy used since 2005 in the treatment of chronic myelogenous leukemia and de novo Philadelphia positive acute lymphoblastic leukaemia patients, intolerant or resistant to imatinib. Despite its high efficacy in such patients in terms of hematologic, cytogenetic and molecular responses, the onset of frequent and sometimes serious side effects particularly in advanced phase patients, especially myelosuppressions and pleural effusions, may impair optimal administration of the drug...
September 2008: Bulletin du Cancer
Tal Shapira, David Pereg, Michael Lishner
The prevalence of pregnancy associated leukemia is approximately 1 case out of 10,000 pregnancies. This rare occurrence precludes the conducting of large, prospective studies to examine diagnostic, management and outcome issues. The treatment of a pregnant woman with leukemia may be associated with severe adverse fetal outcome including death and malformations, and therefore poses a difficult challenge for both the patient and the attending physician. Chemotherapy during the 1st trimester is associated with an increased risk for congenital malformations...
September 2008: Blood Reviews
Norma E Tartas, María C Foncuberta, Julio C Sánchez Avalos
The most common hematological malignancy in pregnant patients is Hodgkin's lymphoma, but other diseases such as chronic and acute leukemia or non Hodgkin's lymphoma have also been reported. In the last decade, new drugs have changed the prognostic of acute promyelocytic leukemia, chronic myeloid leukemia and non Hodgkin's lymphoma. Herein we present updated information on drugs and treatments, new developments, mechanism of action, clinical application, experience on treatment outcomes, adverse effects and teratogenesis, with the objective of orienting hematologists, oncologists and pediatricians...
2007: Medicina
No abstract text is available yet for this article.
June 15, 1949: New York State Journal of Medicine
Abid Jameel, Shahnaz Nadir Jamil
OBJECTIVE: To To present an experience and results of treatment of pregnant cancer patients with cytotoxic chemotherapy from second trimester of pregnancy. METHODS: Eighteen consecutive pregnant patients treated at Khyber Teaching Hospital, Peshawar between December 2000 and August 2006 for different types of malignancies are reported. Six patients (33%) had breast cancer, four (22%) had chronic myeloid leukaemia, two (11%) had Hodgkin's disease, two (11%) had acute myeloid leukaemia and one each had recurrent ovarian carcinoma (5...
September 2007: JPMA. the Journal of the Pakistan Medical Association
Val R Adams, Markos Leggas
BACKGROUND: Sunitinib was approved by the US Food and Drug Administration (FDA) on January 26, 2006, for the treatment of metastatic renal cell carcinoma (mRCC) and gastrointestinal stromal tumor (GIST) in patients who have failed to respond to imatinib or were unable to tolerate it. OBJECTIVE: This article reviews the pharmacology, pharmacokinetics, and pharmacodynamics of sunitinib; potential drug interactions; and the results of clinical trials evaluating its efficacy and tolerability...
July 2007: Clinical Therapeutics
Philip R Cohen
Sweet's syndrome (the eponym for acute febrile neutrophilic dermatosis) is characterized by a constellation of clinical symptoms, physical features, and pathologic findings which include fever, neutrophilia, tender erythematous skin lesions (papules, nodules, and plaques), and a diffuse infiltrate consisting predominantly of mature neutrophils that are typically located in the upper dermis. Several hundreds cases of Sweet's syndrome have been published. Sweet's syndrome presents in three clinical settings: classical (or idiopathic), malignancy-associated, and drug-induced...
July 26, 2007: Orphanet Journal of Rare Diseases
Ramzi Aboujaoude, Jesus Alvarez, Manuel Alvarez, Abdullah Al Khan
Acute leukemia is a rare malignancy of pregnancy. When it develops, there are many complications to consider and management becomes exceedingly difficult. We report a case of acute myelogenous leukemia presenting as preeclampsia and fetal demise at 36 weeks of gestation. A 30-year-old multigravida presented with intrauterine fetal demise at 36 weeks' gestation, hypertension, and thrombocytopenia. The patient received platelet and packed red blood cell transfusion, with concurrent prophylactic magnesium sulfate and dexamethasone treatment...
January 2007: American Journal of Perinatology
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