Xing Liu, Chunchun Zhu, Shuke Jia, Hongyan Deng, Jinhua Tang, Xueyi Sun, Xiaoli Zeng, Xiaoyun Chen, Zixuan Wang, Wen Liu, Qian Liao, Huangyuan Zha, Xiaolian Cai, Wuhan Xiao
To effectively protect the host from viral infection while avoiding excessive immunopathology, the innate immune response must be tightly controlled. However, the precise regulation of antiviral innate immunity and the underlying mechanisms remain unclear. Here, we find that sirtuin3 (SIRT3) interacts with mitochondrial antiviral signaling protein (MAVS) to catalyze MAVS deacetylation at lysine residue 7 (K7), which promotes MAVS aggregation, as well as TANK-binding kinase I and IRF3 phosphorylation, resulting in increased MAVS activation and enhanced type I interferon signaling...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America