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https://www.readbyqxmd.com/read/29913541/cost-effectiveness-of-carbetocin-versus-oxytocin-for-prevention-of-postpartum-hemorrhage-resulting-from-uterine-atony-in-women-at-high-risk-for-bleeding-in-colombia
#1
Yaneth Gil-Rojas, Pieralessandro Lasalvia, Fabián Hernández, Camilo Castañeda-Cardona, Diego Rosselli
OBJECTIVE:  To assess the cost-effectiveness of carbetocin versus oxytocin for prevention of postpartum hemorrhage (PPH) due to uterine atony after vaginal delivery/cesarean section in women with risk factors for bleeding. METHODS:  A decision tree was developed for vaginal delivery and another one for cesarean, in which a sequential analysis of the results was obtained with the use of carbetocin and oxytocin for prevention of PPH and related consequences. A third-party payer perspective was used; only direct medical costs were considered...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913526/tolerability-and-efficacy-of-ipragliflozin-in-the-management-of-inadequately-controlled-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#2
Ahmed Elgebaly, Nesrine Abdelazeim, Bassant Abdelazeim, Gehad El Ashal, Omar Mattar, Lubaba Namous, Noha Nasreldin
AIM: Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM). METHODS: We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5...
June 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29913521/comparison-of-efficacy-embolism-rate-and-safety-of-thrombectomy-with-stent-retrievers-in-an-anterior-circulation-stroke-model
#3
Naomi Larsen, Katharina Oberbeck, Rodrigo Lima de Miranda, Jens Trentmann, Jawid Madjidyar, Eckhard Quandt, Olav Jansen
PURPOSE:  Various stent retrievers differing in stent design and mechanical properties are currently available for the treatment of ischemic stroke. We conducted this in vitro study to compare the efficacy, embolism rate, and safety of commercially available stent retrievers and prototypes. MATERIALS AND METHODS:  Whole blood thrombi were produced in a Chandler loop. The thrombi were inserted into the curved M1 segment of a silicone model of the anterior cerebral circulation...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913480/dendrimer-paclitaxel-complexes-for-efficient-treatment-in-ovarian-cancer-study-on-ovcar-3-and-hek293t-cells
#4
Hua Yao, Jinqi Ma
The present paper investigates the enhancement of the therapeutic effect of Paclitaxel (a potent anticancer drug) by increasing its cellular uptake in the cancerous cells with subsequent reduction in its cytotoxic effects. To fulfill these goals the Paclitaxel (PTX)-Biotinylated PAMAM dendrimer complexes were prepared using biotinylation method. The primary parameter of Biotinylated PAMAM with a terminal HN2 group - the degree of biotinylation - was evaluated using HABA assay. The basic integrity of the complex was studied using DSC...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913479/prioritizing-and-modelling-of-putative-drug-target-proteins-of-candida-albicans-by-systems-biology-approach
#5
Tariq Ismail, Nighat Fatima, Syed Aun Muhammad, Syed Saoud Zaidi, Nisar Rehman, Izhar Hussain, Najam Us Sahr Tariq, Imran Amirzada, Abdul Mannan
Candida albicans (Candida albicans) is one of the major sources of nosocomial infections in humans which may prove fatal in 30% of cases. The hospital acquired infection is very difficult to treat affectively due to the presence of drug resistant pathogenic strains, therefore there is a need to find alternative drug targets to cure this infection. In silico and computational level frame work was used to prioritize and establish antifungal drug targets of Candida albicans. The identification of putative drug targets was based on acquiring 5090 completely annotated genes of Candida albicans from available databases which were categorized into essential and non-essential genes...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913456/long-term-oral-administration-of-theaphenon-e-improves-cardiomyocyte-mechanics-and-calcium-dynamics-by-affecting-phospholamban-phosphorylation-and-atp-production
#6
Leonardo Bocchi, Monia Savi, Valeria Naponelli, Rocchina Vilella, Gianluca Sgarbi, Alessandra Baracca, Giancarlo Solaini, Saverio Bettuzzi, Federica Rizzi, Donatella Stilli
BACKGROUND/AIMS: Dietary polyphenols from green tea have been shown to possess cardio-protective activities in different experimental models of heart diseases and age-related ventricular dysfunction. The present study was aimed at evaluating whether long term in vivo administration of green tea extracts (GTE), can exert positive effects on the normal heart, with focus on the underlying mechanisms. METHODS: The study population consisted of 20 male adult Wistar rats...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913449/pre-treatment-with-melatonin-enhances-therapeutic-efficacy-of-cardiac-progenitor-cells-for-myocardial-infarction
#7
Wenya Ma, Fang He, Fengzhi Ding, Lai Zhang, Qi Huang, Chongwei Bi, Xiuxiu Wang, Bingjie Hua, Fan Yang, Ye Yuan, Zhenbo Han, Mengyu Jin, Tianyi Liu, Ying Yu, Benzhi Cai, Yanjie Lu, Zhimin Du
BACKGROUND/AIMS: Melatonin possesses many biological activities such as antioxidant and anti-aging. Cardiac progenitor cells (CPCs) have emerged as a promising therapeutic strategy for myocardial infarction (MI). However, the low survival of transplanted CPCs in infarcted myocardium limits the successful use in treating MI. In the present study, we aimed to investigate if melatonin protects against oxidative stress-induced CPCs damage and enhances its therapeutic efficacy for MI. METHODS: TUNEL assay and EdU assay were used to detect the effects of melatonin and miR-98 on H2O2-induced apoptosis and proliferation...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913448/rapid-electrical-stimulation-increased-cardiac-apoptosis-through-disturbance-of-calcium-homeostasis-and-mitochondrial-dysfunction-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#8
Le Geng, Zidun Wang, Chang Cui, Yue Zhu, Jiaojiao Shi, Jiaxian Wang, Minglong Chen
BACKGROUND/AIMS: Heart failure induced by tachycardia, the most common arrhythmia, is frequently observed in clinical practice. This study was designed to investigate the underlying mechanisms. METHODS: Rapid electrical stimulation (RES) at a frequency of 3 Hz was applied on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for 7 days, with 8 h/day and 24 h/day set to represent short-term and long-term tachycardia, respectively. Age-matched hiPSC-CMs without electrical stimulation or with slow electrical stimulation (1 Hz) were set as no electrical stimulation (NES) control or low-frequency electrical stimulation (LES) control...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913437/thymoquinone-attenuates-myocardial-ischemia-reperfusion-injury-through-activation-of-sirt1-signaling
#9
Yunyang Lu, Yingda Feng, Dan Liu, Zhiran Zhang, Kai Gao, Wei Zhang, Haifeng Tang
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (MI/R) injury is a leading factor responsible for damage in myocardial infarction, resulting in additional injury to cardiac tissues involved in oxidative stress, inflammation, and apoptosis. Thymoquinone (TQ), the main constituent of Nigella sativa L. seeds, has been reported to possess various biological activities. However, few reports regarding myocardial protection are available at present. Therefore, this study was conducted aiming to investigate the protective effect of TQ against MI/R injury and to clarify its potential mechanism...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913426/heat-treatment-improves-the-immunomodulatory-and-cellular-antioxidant-behavior-of-a-natural-flavanone-eriodictyol
#10
Rihab Khlifi, Zaineb Dhaouefi, Mouna Maatouk, Aicha Sassi, Najet Boudhiba, Irina Ioannou, Kamel Ghedira, Leila Chekir-Ghedira, Soumaya Kilani-Jaziri
Plants and natural molecules are generally consumed not in raw state but after different processing conditions (heating, mechanical agitation or cooking). The understanding of the chemistry and biological outcome of thermal treatment is still scarce. In the current study, Eriodictyol, a natural flavanone, has undergone heat treatment, generating hence three different products ((3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, (3-(3,4-dihydroxyphenyl) propanal) and an unidentified component). The consequences of aforementioned treatment on the immunomodulatory behavior of resulted molecules were evaluated...
June 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29913423/effect-of-aminopeptidase-n-on-functions-and-fertility-of-mouse-spermatozoa-in-vitro
#11
Amena Khatun, Kyu-Ho Kang, Do-Yeal Ryu, Md Saidur Rahman, Woo-Sung Kwon, Myung-Geol Pang
Aminopeptidase N (APN) is defined as a multifunctional enzyme, which regulate cellular physiology of a wide variety of cells in human. Earlier studies reported that mammalian semen shares this common enzyme as a major protein of seminal plasma that has correlation with male fertility, while the regulatory mechanisms of APN in spermatozoa are still far from being well understood. Present study was designed to investigate the role of APN in biological and chemical functions of spermatozoa using an in vitro antagonistic approach...
June 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29913419/bacterial-toxicity-of-exfoliated-black-phosphorus-nanosheets
#12
Zhiqiang Xiong, Xuejiao Zhang, Siyu Zhang, Lei Lei, Wei Ma, Dengyu Li, Weidong Wang, Qing Zhao, Baoshan Xing
Newly emerged two-dimensional material, black phosphorus (BP) shows promising applications in many fields owing to its superior properties. Despite the biological effects of BP were studied, its environmental impacts have not yet received enough attention. In this study, the bacterial toxicity of exfoliated BP nanosheets was for the first time evaluated against two model bacteria strains, Gram-negative Escherichia coli (E. coli) and Gram-positive Bacillus subtilis (B. subtilis). By monitoring the bacterial growth curve and colony counting, the bacterial toxicity of BP nanosheets was examined...
June 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29913407/the-effect-of-dichloroacetate-in-mouse-models-of-epilepsy
#13
Dylan Durie, Tanya S McDonald, Karin Borges
A recent report has found that glucose oxidation and the activity of pyruvate dehydrogenase (PDH) are reduced in the chronic stage of the pilocarpine mouse epilepsy model. This is likely caused by increased phosphorylation by PDH kinase of the E1α subunit of PDH, downregulating its activity. Inhibition of this phosphorylation has not yet been explored as a possible approach to treat epilepsy. Chronic dichloroacetate (DCA, 50 and 100 mg/kg/day) treatment was tested in acute seizure and the chronic pilocarpine models...
June 15, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29913395/the-effect-of-nonsteroidal-anti-inflammatory-drugs-on-bone-healing-in-humans-a-qualitative-systematic-review
#14
REVIEW
Alain Borgeat, Christian Ofner, Andrea Saporito, Mazda Farshad, José Aguirre
STUDY OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in postoperative pain management. While an increasing number of in vitro and animal studies point toward an inhibitory effect of NSAIDs on bone healing process, the few existing retro- and prospective clinical studies present conflicting data. DESIGN: The aim of this qualitative, systematic review was to investigate the impact of perioperative use of NSAIDs in humans on postoperative fracture/spinal fusion healing compared to other used analgesics measured as fracture nonunion with radiological control...
June 15, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29913392/evaluation-of-ultrasound-guided-erector-spinae-plane-block-for-postoperative-analgesia-in-laparoscopic-cholecystectomy-a-prospective-randomized-controlled-clinical-trial
#15
Serkan Tulgar, Mahmut Sertan Kapakli, Ozgur Senturk, Onur Selvi, Talat Ercan Serifsoy, Zeliha Ozer
STUDY OBJECTIVE: Laparoscopic cholecystectomy (LC) is a commonly performed minimally invasive procedure that has led to a decrease in procedure-related mortality and morbidity. However, LC requires analgesia that blocks both visceral and somatic nerve fibers. In this study, we evaluated the effectiveness of Erector Spinae Plane Block (ESPB) for postoperative analgesia management in LC. DESIGN: Single-blinded, prospective, randomized, efficiency study. SETTING: Tertiary university hospital, postoperative recovery room & ward...
June 15, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29913384/prediction-of-micropollutant-abatement-during-homogeneous-catalytic-ozonation-by-a-chemical-kinetic-model
#16
Yang Guo, Huijiao Wang, Bin Wang, Shubo Deng, Jun Huang, Gang Yu, Yujue Wang
Prediction of micropollutant abatements by catalytic ozonation is critical for its process design and optimization in water treatment. In this study, a chemical kinetic model based on ozone (O3 ) and hydroxyl radical (OH) rate constants (kO3 and kOH ) and O3 and OH exposures is proposed for the generalized prediction of micropollutant abatement by homogeneous catalytic ozonation. Several micropollutants with kO3 ranging from <0.15 to 1.0 × 106  M-1  s-1 were spiked in water matrices (deionized water and surface water) and then treated by ozonation alone and homogeneous catalytic ozonation with varying transition metals (Ti2+ , Co2+ , Ni2+ , Zn2+ , Cu2+ , Mn2+ , Fe2+ , and Fe3+ )...
June 14, 2018: Water Research
https://www.readbyqxmd.com/read/29913379/the-role-of-social-support-in-family-socio-economic-disparities-in-depressive-symptoms-during-early-pregnancy-evidence-from-a-chinese-birth-cohort
#17
Dong-Mei Wei, Shiu Lun Au Yeung, Jian-Rong He, Wan-Qing Xiao, Jin-Hua Lu, Si Tu, Nian-Nian Chen, Kin Bong Hubert Lam, Kar-Keung Cheng, Gabriel M Leung, Hui-Min Xia, C Mary Schooling, Xiu Qiu
BACKGROUND: Few studies have examined the association between a composite measure of family socio-economic position (SEP)2 and depressive symptoms among Chinese pregnant women, nor any potential underlying mechanisms which may be amenable to preventative interventions. METHODS: We investigated the association between a composite SEP measure and depressive symptoms during early pregnancy, and tested for mediation by social support and moderation by parity in the Born in Guangzhou Cohort Study (n = 12,382) using adjusted logistic regression and causal mediation analysis...
June 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29913354/benefits-of-an-increased-prosthetic-ankle-range-of-motion-for-individuals-with-a-trans-tibial-amputation-walking-with-a-new-prosthetic-foot
#18
Daniel W W Heitzmann, Firooz Salami, Alan R De Asha, Julia Block, Cornelia Putz, Sebastian I Wolf, Merkur Alimusaj
BACKGROUND: Individuals with trans-tibial amputation show a greater peak prosthetic ankle power (push- off) when using energy storing and returning (ESAR) prosthetic feet as compared to solid-ankle cushion-heel feet. ESAR feet further contribute to the users' body support and thus limit prosthetic ankle motion. To improve ankle motion, articulating prosthetic feet have been introduced. However, articulating feet may diminish push-off. RESEARCH QUESTION: Does a novel prosthetic foot, with a serial layout of carbon fibre leaf springs, connected by a multi-centre joint construction, have advantages in kinematics and kinetics over a conventional ESAR prosthetic foot?> METHODS: Eleven individuals with unilateral trans-tibial amputation were fitted with the novel foot (NF) and a conventional ESAR Foot (CF) and underwent 3D gait analysis...
June 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29913316/aging-modulates-fronto-temporal-cortical-interactions-during-lexical-production-a-dynamic-causal-modeling-study
#19
E Hoyau, A Roux-Sibilon, N Boudiaf, C Pichat, E Cousin, A Krainik, A Jaillard, C Peyrin, M Baciu
In this dynamic causal modeling (DCM) study, we evaluated the effect of age on the effective connectivity of a cerebral network involved in lexical production. Younger and older adults performed an object naming task during fMRI. The DCM was used to explore the interactions between four regions of interest: the occipital cortex, OC; the lateral temporal cortex, LTC; the medial temporal cortex, MTC; and the inferior frontal cortex, IFC. We mainly focused on the modulation of the fronto-temporal interaction, according to the hypothesis that aging requires strategies that modulate the access to the semantic knowledge, either through a neural reserve mechanism (increased MTC-LTC connectivity) or through a neural compensation mechanism (supplementary IFC-MTC connectivity)...
June 15, 2018: Brain and Language
https://www.readbyqxmd.com/read/29913306/selective-dentin-etching-a-potential-method-to-improve-bonding-effectiveness-of-universal-adhesives
#20
Thiago Henrique Scarabello Stape, Patrik Wik, Mustafa Murat Mutluay, Anas Aaqel Salim Al-Ani, Arzu Tezvergil-Mutluay
OBJECTIVES: To evaluate whether selective dentin etching protocols using reduced phosphoric acid (H3 PO4 ) etching-times would affect the resin-dentin interaction of a universal adhesive to improve long-term bonding effectiveness. METHODS: Mid-coronal flat dentin surfaces were produced on sound third molars, selectively etched with 32% H3 PO4 for 3, 5, 10 or 15 s and bonded with a universal adhesive (Scotchbond Universal, 3 M ESPE: SU). SU in self-etch mode and a three-step etch-and-rinse adhesive were used as control groups...
June 8, 2018: Journal of the Mechanical Behavior of Biomedical Materials
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