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https://www.readbyqxmd.com/read/28347132/radiolabeled-peptides-current-and-new-perspectives
#1
Marta Opalinska, Alicja Hubalewska-Dydejczyk, Anna Sowa-Staszczak
Radiolabeled peptides have been the subject of research for over 20 years and during that time possibility/variety of peptide receptor imaging and later targeted radiotherapy increased significantly. The targeted receptors belong to the large family of G-protein-coupled receptors or tyrosine kinases receptors partially connected with them. They both regulate large signaling networks, control multiple cell functions and are implicated in many diseases including cancers. The essential feature of peptides used in nuclear medicine involves their ability to binding with high affinity and specify to their receptors overexpressed on tumor cells...
June 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28346903/the-oceanus-statue-of-the-fontana-di-trevi-rome-the-analysis-of-black-crust-as-a-tool-to-investigate-the-urban-air-pollution-and-its-impact-on-the-stone-degradation
#2
Mauro F La Russa, Paola Fermo, Valeria Comite, Cristina M Belfiore, Donatella Barca, Annamaria Cerioni, Marina De Santis, Lorena Francesca Barbagallo, Michela Ricca, Silvestro A Ruffolo
This paper deals with the analysis of black crust coming from the statue of Oceanus belonging to the Fontana di Trevi (Rome). This monument is undoubtedly one of the main touristic attractions of Rome. During the restoration held between 2014 and 2015, some diagnostic analyses had been carried out. It has been highlighted that the sheltered surfaces suffer the formation of black crust, especially on the marble statues. The possibility to sample those degradation products, together with the unaltered substrate, represented an excellent opportunity to characterize the marble itself, to assess the impact of the urban air pollution on the stone material, and to detect the pollutant on a precise timescale...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346867/the-challenges-and-advances-in-diagnosis-of-vector-borne-diseases-where-do-we-stand
#3
Josipa Kuleš, Lenka Potocnakova, Katarina Bhide, Laura Tomassone, Hans-Peter Fuehrer, Anita Horvatić, Asier Galan, Nicolas Guillemin, Petra Nižić, Vladimir Mrljak, Mangesh Bhide
Vector-borne diseases (VBD) are of major importance to human and animal health. In recent years, VBD have been emerging or re-emerging in many geographical areas, alarming new disease threats and economic losses. The precise diagnosis of many of these diseases still remains a major challenge because of the lack of comprehensive data available on accurate and reliable diagnostic methods. Here, we conducted a systematic and in-depth review of the former, current, and upcoming techniques employed for the diagnosis of VBD...
March 27, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28346815/improvement-of-identification-methods-for-honeybee-specific-lactic-acid-bacteria-future-approaches
#4
Sepideh Lamei, Yue O O Hu, Tobias C Olofsson, Anders F Andersson, Eva Forsgren, Alejandra Vásquez
Honeybees face many parasites and pathogens and consequently rely on a diverse set of individual and group-level defenses to prevent disease. The crop microbiota of Apis mellifera, composed of 13 Lactic Acid Bacterial (LAB) species within the genera Lactobacillus and Bifidobacterium, form a beneficial symbiotic relationship with each other and the honeybee to protect their niche and their host. Possibly playing a vital role in honeybee health, it is important that these honeybee specific Lactic Acid Bacterial (hbs-LAB) symbionts can be correctly identified, isolated and cultured, to further investigate their health promoting properties...
2017: PloS One
https://www.readbyqxmd.com/read/28346509/systematic-identification-of-phosphorylation-mediated-protein-interaction-switches
#5
Matthew J Betts, Oliver Wichmann, Mathias Utz, Timon Andre, Evangelia Petsalaki, Pablo Minguez, Luca Parca, Frederick P Roth, Anne-Claude Gavin, Peer Bork, Robert B Russell
Proteomics techniques can identify thousands of phosphorylation sites in a single experiment, the majority of which are new and lack precise information about function or molecular mechanism. Here we present a fast method to predict potential phosphorylation switches by mapping phosphorylation sites to protein-protein interactions of known structure and analysing the properties of the protein interface. We predict 1024 sites that could potentially enable or disable particular interactions. We tested a selection of these switches and showed that phosphomimetic mutations indeed affect interactions...
March 27, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28346329/cardiac-computed-tomography-radiomics-a-comprehensive-review-on-radiomic-techniques
#6
Márton Kolossváry, Miklós Kellermayer, Béla Merkely, Pál Maurovich-Horvat
Radiologic images are vast three-dimensional data sets in which each voxel of the underlying volume represents distinct physical measurements of a tissue-dependent characteristic. Advances in technology allow radiologists to image pathologies with unforeseen detail, thereby further increasing the amount of information to be processed. Even though the imaging modalities have advanced greatly, our interpretation of the images has remained essentially unchanged for decades. We have arrived in the era of precision medicine where even slight differences in disease manifestation are seen as potential target points for new intervention strategies...
March 24, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28346279/sub-basal-corneal-nerve-plexus-analysis-using-a-new-software-technology
#7
Hatim Batawi, Nabeel Shalabi, Madhura Joag, Tulay Koru-Sengul, Jorge Rodriguez, Parke T Green, Mauro Campigotto, Carol L Karp, Anat Galor
PURPOSE: To study sub-basal corneal nerve plexus (SCNP) parameters by in vivo corneal confocal microscopy using a new software technology and examine the effect of demographics and diabetes mellitus (DM) on corneal nerves morphology. METHODS: A Confoscan 4 (Nidek Technologies) was used in this cross-sectional study to image the SCNP in 84 right eyes at the Miami Veterans Affairs eye clinic. Images were analyzed using a new semiautomated nerve analysis software program (The Corneal Nerve Analysis tool) which evaluated 9 parameters including nerve fibers length (NFL) and nerve fibers length density (NFLD)...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28346025/guidance-on-radiation-dose-limits-for-the-lens-of-the-eye-overview-of-the-recommendations-in-ncrp-commentary-no-26
#8
Lawrence T Dauer, Elizabeth A Ainsbury, Joseph Dynlacht, David Hoel, Barbara E K Klein, Don Mayer, Christina R Prescott, Raymond H Thornton, Eliseo Vano, Gayle E Woloschak, Cynthia M Flannery, Lee E Goldstein, Nobuyuki Hamada, Phung K Tran, Michael P Grissom, Eleanor A Blakely
PURPOSE: This review summarizes the conclusions and recommendations of the new NCRP Commentary No. 26 guidance on radiation dose limits for the lens of the eye. The NCRP also addressed radiation protection principles with respect to the lens of the eye, discussed the current understanding of eye biology and lens effects, reviewed and evaluated epidemiology, and assessed exposed populations with the potential for significant radiation exposures to the lens while suggesting monitoring and protection practices...
March 27, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28345997/evaluation-of-a-new-method-to-determine-the-tibial-tuberosity-advancement-distance-required-to-reduce-the-patellar-tendon-tibial-plateau-angle-to-90%C3%A2-with-the-modified-maquet-technique-in-dogs
#9
Paul Pillard, Veronique Livet, Quentin Cabon, Camille Bismuth, Juliette Sonet, Denise Remy, Didier Fau, Claude Carozzo, Eric Viguier, Thibaut Cachon
OBJECTIVE To assess use of a new radiographic method to determine the distance by which the tibial tuberosity should be advanced to reduce the patellar tendon-tibial plateau angle (PTA) to 90° by means of the modified Maquet technique (MMT) in dogs. SAMPLE 24 pelvic limbs from 12 adult medium-sized to large-breed canine cadavers. PROCEDURES Radiographs of stifle joints at 135° extension in true lateral position were used to determine tibial tuberosity advancement distances for use in the MMT. A method was devised to incorporate the planned osteotomy axis; distal patellar translations of 0, 3, 5, or 10 mm; and advancement cage implant application level along the osteotomy site in advancement planning measurements...
April 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28345995/description-and-comparison-of-excretory-urography-performed-during-radiography-and-computed-tomography-for-evaluation-of-the-urinary-system-in-healthy-new-zealand-white-rabbits-oryctolagus-cuniculus
#10
Laura Vilalta, Raul Altuzarra, Yvonne Espada, Elisabet Dominguez, Rosa Novellas, Jaime Martorell
OBJECTIVE To evaluate the usefulness of excretory urography performed during radiography (REU) and CT (CTEU) in healthy rabbits, determine timings of urogram phases, and compare sensitivities of REU and CTEU for detection of these phases. ANIMALS 13 New Zealand White rabbits (Oryctolagus cuniculus). PROCEDURES Rabbits were screened for signs of systemic and urinary tract disease. An REU examination of each was performed, followed ≥ 5 days later by a CTEU examination. Contrast images from each modality were evaluated for quality of opacification and intervals between initiation of contrast medium administration and detection of various urogram phases...
April 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28345907/simulating-protein-mediated-hydrolysis-of-atp-and-other-nucleoside-triphosphates-by-combining-qm-mm-molecular-dynamics-with-advances-in-metadynamics
#11
Rui Sun, Olaseni Sode, James F Dama, Gregory A Voth
The protein mediated hydrolysis of nucleoside triphosphates such as ATP or GTP is one of the most important and challenging biochemical reactions in nature. The chemical environment (water structure, catalytic metal, and amino acid residues) adjacent to the hydrolysis site contains hundreds of atoms, usually greatly limiting the amount of the free energy sampling that one can achieve from computationally demanding electronic structure calculations such as QM/MM simulations. Therefore, the combination of QM/MM molecular dynamics with the recently developed Transition-tempered Metadynamics (TTMetaD), an enhanced sampling method that can provide a high-quality free energy estimate at an early stage in a simulation, is an ideal approach to address the biomolecular nucleoside triphosphate hydrolysis problem...
March 27, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28345881/silane-and-germane-molecular-electronics
#12
Timothy A Su, Haixing Li, Rebekka S Klausen, Nathaniel T Kim, Madhav Neupane, James L Leighton, Michael L Steigerwald, Latha Venkataraman, Colin Nuckolls
This Account provides an overview of our recent efforts to uncover the fundamental charge transport properties of Si-Si and Ge-Ge single bonds and introduce useful functions into group 14 molecular wires. We utilize the tools of chemical synthesis and a scanning tunneling microscopy-based break-junction technique to study the mechanism of charge transport in these molecular systems. We evaluated the fundamental ability of silicon, germanium, and carbon molecular wires to transport charge by comparing conductances within families of well-defined structures, the members of which differ only in the number of Si (or Ge or C) atoms in the wire...
March 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28345716/spontaneous-nacl-doped-ice-at-seawater-conditions-focus-on-the-mechanisms-of-ion-inclusion
#13
M M Conde, M Rovere, P Gallo
Molecular dynamics simulations on the microsecond time scale have been performed on an aqueous solution of TIP4P/2005 water and NaCl by using the direct coexistence technique to study the ice growth and the ice/liquid interface water. At ambient pressure, for temperatures above the eutectic point of the salt and at seawater concentrations the brine rejection phenomenon and the spontaneous growth of an ice slab doped by the salt are obtained, as found in natural terrestrial and planetary environments. Experiments indicate that Cl(-) goes via substitution to ice sites...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28345699/gold-and-iodine-diffusion-in-large-area-perovskite-solar-cells-under-illumination
#14
S Cacovich, L Ciná, F Matteocci, G Divitini, P A Midgley, A Di Carlo, C Ducati
Operational stability is the main issue hindering the commercialisation of perovskite solar cells. Here, a long term light soaking test was performed on large area hybrid halide perovskite solar cells to investigate the morphological and chemical changes associated with the degradation of photovoltaic performance occurring within the devices. Using Scanning Transmission Electron Microscopy (STEM) in conjunction with EDX analysis on device cross sections, we observe the formation of gold clusters in the perovskite active layer as well as in the TiO2 mesoporous layer, and a severe degradation of the perovskite due to iodine migration into the hole transporter...
March 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28345565/upgradation-and-modernization-of-eye-banking-services-integrating-tradition-with-innovative-policies-and-current-best-practices
#15
Radhika Tandon, Archita Singh, Noopur Gupta, M Vanathi, Vivek Gupta
PURPOSE: The purpose of this study is to review the history and evolution of the National Eye Bank (NEB) and analyze the impact over the years and report the outcome of the invested resources. METHODS: Review of archival material, records, project reports, policy and procedures' manuals, and publications was done. Descriptive and analytical processing of data obtained was undertaken. Parameters evaluated included total collection, transplantation, utilization rates of donor cornea, changing trends over time in terms of numbers and duration of recipients waiting, impactful research translated into changes in standard operating protocols, new facilities, and subsequent effects on numbers or quality assurance measures and overview of major achievements...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345515/treatment-of-salivary-stones-by-intraductal-pneumatic-lithotripsy-a-preliminary-presentation-of-the-stonebreaker-with-sterile-bag-covering
#16
P A Oddon, G Royer, N Graillon, F Marchal, C Chossegros, J M Foletti
INTRODUCTION: Sialendoscopy has changed the management of obstructive sialadenitis. Nowadays, minimally invasive techniques evolve to preserve salivary gland function. Intraductal lithotripsy allows stones fragmentation and retrieval without opening the salivary duct. We report our experience with the StoneBreaker (SB), a new lithotripter with improvement using a sterile bag that permits reuse of the SB without passing to sterilization. TECHNICAL NOTE: The non-sterilized SB was used into a sterile camera sleeve in 5 patients, 3 submandibular lithiases and 2 parotid lithiases...
February 17, 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28345351/shape-memory-characteristics-of-o157-antigenic-cavities-generated-on-nanocomposites-consisting-of-copolymer-encapsulated-gold-nanoparticles
#17
Takamasa Kinoshita, Dung Quang Nguyen, Dung Quynh Le, Kengo Ishiki, Hiroshi Shiigi, Tsutomu Nagaoka
Nanometer-sized composite particles, which consisted of gold nanoparticles encapsulated by an N-isopropylacrylamide copolymer, were successfully synthesized using a one-step process. Shape complementary cavities of the O157-antigen were formed on the composite utilizing temperature-dependent affinity changes of the copolymer. The composite bound to enterohemorrhagic Escherichia coli (E. coli) O157 at 298 K and enhanced light-scattering intensity of the cell due to the optical properties of the gold nanoparticles...
March 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28345307/quality-indicators-for-early-stage-hodgkin-s-lymphoma
#18
Daniel E Roos, Hui C Tee
INTRODUCTION: The purpose of this project was to devise simple, practicable quality indicators (QIs) for the treatment of early stage (I-II) Hodgkin's lymphoma (ESHL), and to test their applicability retrospectively at a single large teaching hospital. METHODS: Of the available treatment guidelines, we chose the two eviQ (evidence and Quality, Cancer Institute New South Wales) documents first published in early 2012 (updated in 2015) for ESHL favourable and ESHL unfavourable (based upon German Hodgkin Study Group practice) as being most relevant to the Australian setting, and selected nine QIs from them viz...
March 27, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28345211/3d-echocardiographic-analysis-of-aortic-annulus-for-transcatheter-aortic-valve-replacement-using-novel-aortic-valve-quantification-software-comparison-with-computed-tomography
#19
Anuj Mediratta, Karima Addetia, Diego Medvedofsky, Robert J Schneider, Eric Kruse, Atman P Shah, Sandeep Nathan, Jonathan D Paul, John E Blair, Takeyoshi Ota, Husam H Balkhy, Amit R Patel, Victor Mor-Avi, Roberto M Lang
BACKGROUND: With the increasing use of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS), computed tomography (CT) remains the standard for annulus sizing. However, 3D transesophageal echocardiography (TEE) has been an alternative in patients with contraindications to CT. We sought to (1) test the feasibility, accuracy, and reproducibility of prototype 3DTEE analysis software (Philips) for aortic annular measurements and (2) compare the new approach to the existing echocardiographic techniques...
March 27, 2017: Echocardiography
https://www.readbyqxmd.com/read/28344976/a-metataxonomic-approach-could-be-considered-for-cattle-clinical-mastitis-diagnostics
#20
Joanne W H Oultram, Erika K Ganda, Sarah C Boulding, Rodrigo C Bicalho, Georgios Oikonomou
Mastitis is one of the most costly diseases affecting the dairy industry, and identification of the causative microorganism(s) is essential. Here, we report the use of next-generation sequencing of bacterial 16S rRNA genes for clinical mastitis diagnosis. We used 65 paired milk samples, collected from the mastitic and a contralateral healthy quarter of mastitic dairy cattle to evaluate the technique as a potential alternative to bacterial culture or targeted PCR. One large commercial dairy farm was used, with one trained veterinarian collecting the milk samples...
2017: Frontiers in Veterinary Science
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