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D-dimer and pancreatitis

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https://www.readbyqxmd.com/read/28254727/predicting-the-incidence-of-portosplenomesenteric-vein-thrombosis-in-patients-with-acute-pancreatitis-using-classification-and-regression-tree-algorithm
#1
Yang Fei, Kun Gao, Jian Hu, Jianfeng Tu, Wei-Qin Li, Wei Wang, Guang-Quan Zong
BACKGROUND AND OBJECTIVE: The accurate prediction of portosplenomesenteric vein thrombosis (PVT) in patients with acute pancreatitis(AP) is very important but may also be difficult because of our insufficient understanding of the characteristics of AP-induced PVT. The purpose of this study is to design a decision tree model that provides critical factors associated with PVT using an approach that makes use of classification and regression tree (CART) algorithm. METHODS: The analysis included 353 patients with AP who were admitted between January 2011 and December 2015...
February 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28246056/predicting-risk-for-portal-vein-thrombosis-in-acute-pancreatitis-patients-a-comparison-of-radical-basis-function-artificial-neural-network-and-logistic-regression-models
#2
Yang Fei, Jian Hu, Kun Gao, Jianfeng Tu, Wei-Qin Li, Wei Wang
OBJECTIVE: To construct a radical basis function (RBF) artificial neural networks (ANNs) model to predict the incidence of acute pancreatitis (AP)-induced portal vein thrombosis. METHODS: The analysis included 353 patients with AP who had admitted between January 2011 and December 2015. RBF ANNs model and logistic regression model were constructed based on eleven factors relevant to AP respectively. Statistical indexes were used to evaluate the value of the prediction in two models...
February 24, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28222624/antithrombin-iii-and-d-dimer-levels-as-indicators-of-disease-severity-in-patients-with-hyperlipidaemic-or-biliary-acute-pancreatitis
#3
Ning Yang, Jianyu Hao, Donglei Zhang
Objective To assess changes in anticoagulation and fibrinolytic systems between biliary and hyperlipidaemic acute pancreatitis (AP). Methods Patients with biliary or hyperlipidaemic AP were enrolled. Demographic and clinical data were collected, and antithrombin III (ATIII), protein C, protein S, and D-dimer levels were investigated. Results A total of 45 patients with biliary AP and 50 patients with hyperlipidaemic AP were included (68 with mild AP and 27 with moderately-severe AP). ATIII and protein C levels in the mild AP group were significantly higher, but prothrombin time and D-dimer were significantly lower, versus the moderately-severe AP group...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28219450/evaluation-of-serum-d-dimer-fibrinogen-and-ca19-9-for-postoperative-monitoring-and-survival-prediction-in-resectable-pancreatic-carcinoma
#4
Junli Cao, Zhanzhao Fu, Liming Gao, Xin Wang, Shaohui Cheng, Xiuchao Wang, He Ren
BACKGROUND: We sought to investigate the efficacy of serum D-dimer, fibrinogen, and CA19-9 for postoperative monitoring and prediction of survival in patients with resectable pancreatic carcinoma (PC). METHODS: One hundred and nineteen patients with resectable PC were enrolled. Serum D-dimer, fibrinogen, and CA19-9 values were analyzed before surgery and at the stages of relapse-free and progression disease. RESULTS: D-dimer, fibrinogen, and CA19-9 were significantly higher at the active stage of PC than those at the relapse-free stage [1059...
February 20, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28208708/the-interplay-between-inflammation-coagulation-and-endothelial-injury-in-the-early-phase-of-acute-pancreatitis-clinical-implications
#5
REVIEW
Paulina Dumnicka, Dawid Maduzia, Piotr Ceranowicz, Rafał Olszanecki, Ryszard Drożdż, Beata Kuśnierz-Cabala
Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild local inflammation to severe systemic involvement resulting in substantial mortality. Early pathologic events in AP, both local and systemic, are associated with vascular derangements, including endothelial activation and injury, dysregulation of vasomotor tone, increased vascular permeability, increased leukocyte migration to tissues, and activation of coagulation. The purpose of the review was to summarize current evidence regarding the interplay between inflammation, coagulation and endothelial dysfunction in the early phase of AP...
February 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28133197/-a-case-of-early-onset-rapidly-progressive-cerebral-infarction-with-trousseau-s-syndrome-in-a-patient-with-pancreatic-cancer-undergoing-surgery
#6
Norikazu Yogi, Hiroyuki Nojima, Hiroaki Shimizu, Masayuki Ohtsuka, Atsushi Kato, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Masaru Miyazaki
Trousseau's syndrome refers to cerebral infarction associated with hypercoagulability caused by cancer. Here, we report a case of Trousseau's syndrome in a patient with pancreatic cancer undergoing surgery. A 71-year-old woman was diagnosed with pancreatic head cancer with portal vein invasion; she underwent pancreaticoduodenectomy combined with portal vein resection. Pathological examination showed poorly differentiated adenocarcinoma with para-aortic lymph nodal metastasis. Although the patient had an uneventful postoperative course, she suddenly developed right hemiplegia and dysarthria 6 weeks after surgery, resulting in multiple cerebral infarctions scattered over both hemispheres...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27929426/serum-soluble-fms-like-tyrosine-kinase-1-sflt-1-predicts-the-severity-of-acute-pancreatitis
#7
Paulina Dumnicka, Mateusz Sporek, Małgorzata Mazur-Laskowska, Piotr Ceranowicz, Marek Kuźniewski, Ryszard Drożdż, Tadeusz Ambroży, Rafał Olszanecki, Beata Kuśnierz-Cabala
Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP severity. Adult patients (66) with AP were recruited, including 46 with mild (MAP), 15 with moderately-severe (MSAP) and 5 with severe AP (SAP). Serum and urine samples were collected twice. Serum sFlt-1 was measured with automated electrochemiluminescence immunoassay...
December 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27835633/tumor-specific-d-dimer-concentration-ranges-and-influencing-factors-a-cross-sectional-study
#8
Jing Yu, Dongqing Li, Dansheng Lei, Feng Yuan, Feng Pei, Huifeng Zhang, Anming Yu, Kun Wang, Hu Chen, Liang Chen, Xianglei Wu, Xianli Tong, Yefu Wang
D-dimer level in cancer patients is associated with risk of venous thromboembolism and deep venous thrombosis. Most cancer patients have "abnormal" D-dimer levels based on the current normal reference range. To investigate tumor-specific D-dimer reference range, we compared D-dimer levels for nine different tumour types with healthy controls by using simultaneous quantile regression and constructing a median, 5th percentile, and 95th percentile model of normal tumour D-dimer concentration. Associations with tumour primary site, stage, pathological type, and treatment were also explored...
2016: PloS One
https://www.readbyqxmd.com/read/27763956/concentration-of-d-dimers-in-bile-a-novel-marker-of-pancreatic-cancer-enhancing-accuracy-of-standard-ca19-9-measurement-dual-test-hypothesis
#9
Adam Durczynski, Anna Kumor, Piotr Grzelak, Marcin Strzelczyk, Piotr Hogendorf, Grazyna Poznanska, Aleksander Skulimowski, Dariusz Szymanski, Janusz Strzelczyk
No abstract text is available yet for this article.
January 2017: Pancreas
https://www.readbyqxmd.com/read/27575020/interfering-with-the-dimerization-of-the-erbb-receptors-by-transmembrane-domain-derived-peptides-inhibits-tumorigenic-growth-in-vitro-and-in-vivo
#10
Erez M Bublil, Tomer Cohen, Christopher J Arnusch, Adi Peleg, Gur Pines, Sara Lavi, Yosef Yarden, Yechiel Shai
The ErbB family of tyrosine kinase receptors is a key element in preserving cell growth homeostasis. This family is comprised of four single-transmembrane domain proteins designated ErbB-1-4. Ligand binding initiates dimerization followed by tyrosine phosphorylation and signaling, which when uncontrolled lead to cancer. Accordingly, extensive research has been devoted to finding ErbB-intercepting agents, directed against ErbB-1 and ErbB-2, but so far, no inhibitor has targeted the transmembrane domain (TMD), which is instrumental for receptor dimerization and activation...
October 4, 2016: Biochemistry
https://www.readbyqxmd.com/read/27498584/risk-factors-of-infected-pancreatic-necrosis-secondary-to-severe-acute-pancreatitis
#11
Liang Ji, Jia-Chen Lv, Zeng-Fu Song, Mai-Tao Jiang, Le Li, Bei Sun
BACKGROUND: Severe acute pancreatitis (SAP) remains a clinical challenge with considerable morbidity and mortality. An early identification of infected pancreatic necrosis (IPN), a life-threatening evolution secondary to SAP, is obliged for a more preferable prognosis. Thus, the present study was conducted to identify the risk factors of IPN secondary to SAP. METHODS: The clinical data of patients with SAP were retrospectively analyzed. Univariate and multivariate logistic regression analyses were sequentially performed to assess the associations between the variables and the development of IPN secondary to SAP...
August 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27434293/neutrophil-lymphocyte-ratio-helps-select-metastatic-pancreatic-cancer-patients-benefitting-from-oxaliplatin
#12
Vincenzo Formica, Cristina Morelli, Patrizia Ferroni, Antonella Nardecchia, Manfredi Tesauro, Stefania Pellicori, Vittore Cereda, Antonio Russo, Silvia Riondino, Fiorella Guadagni, Mario Roselli
BACKGROUND: High Neutrophil/Lymphocyte ratio (NLR), as a measure of enhanced inflammatory response, has been negatively associated with prognosis in patients with localized pancreatic ductal adenocarcinoma (PDA). OBJECTIVE: In the present study, we aimed at investigating the prognostic value of NLR in two homogeneous groups of chemotherapy-naïve metastatic PDA patients. Patients were treated with either gemcitabine (GEM) or gemcitabine/oxaliplatin (GEMOXA). We also assessed whether NLR could identify patients benefiting from the use of oxaliplatin...
September 26, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27368015/cerebral-ischemic-events-in-patients-with-pancreatic-cancer-a-retrospective-cohort-study-of-17-patients-and-a-literature-review
#13
REVIEW
Mathieu Bonnerot, Lisa Humbertjean, Gioia Mione, Jean-Christophe Lacour, Anne-Laure Derelle, Jean-Charles Sanchez, Nolwenn Riou-Comte, Sébastien Richard
Stroke is a dramatic complication of pancreatic cancer with mechanisms related to oncological disease. A better description of the characteristics of cerebrovascular events would help better understand the pathogeny and protect vulnerable patients. We thus conducted a descriptive analysis of clinical, biological, and radiological features of patients from our centers and literature.We reviewed consecutive cases of patients who presented cerebrovascular events and pancreatic cancer in 4 stroke units in Lorrain (France) between January 1, 2009 and March 31, 2015, and all reported cases of literature...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27314431/analogs-of-the-hepatocyte-growth-factor-and-macrophage-stimulating-protein-hinge-regions-act-as-met-and-ron-dual-inhibitors-in-pancreatic-cancer-cells
#14
Kevin J Church, Brett R Vanderwerff, Rachelle R Riggers, Michelle D McMicheal, Beatriz Mateo-Victoriano, Sudharsan R Sukumar, Joseph W Harding
Pancreatic cancer is among the leading causes of cancer death in the USA, with limited effective treatment options. A major contributor toward the formation and persistence of pancreatic cancer is the dysregulation of the hepatocyte growth factor (HGF)/Met (HGF receptor) and the macrophage-stimulating protein (MSP)/Ron (MSP receptor) systems. These systems normally mediate a variety of cellular behaviors including proliferation, survival, and migration, but are often overactivated in pancreatic cancer and contribute toward cancer progression...
September 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27182687/d-dimer-predicts-prognosis-and-non-resectability-in-patients-with-pancreatic-cancer-a-prospective-cohort-study
#15
Mogens T Stender, Anders C Larsen, Mogens Sall, Ole Thorlacius-Ussing
To examine the impact of plasma D-dimer levels in predicting 3-year survival and nonresectability in pancreatic cancer patients. Ninety-five patients were divided into three groups according to plasma D-dimer levels. Kaplan-Meier survival curves and hazard ratios were computed, and diagnostic indices of D-dimer in the prediction of resectability were assessed. The median survival among patients with low, medium and high D-dimer levels was 13.7 [95% confidence interval (CI): 10.2-19.6], 6.2 (95% CI: 2.0-15.1) and 2...
July 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27161678/oc-06-pro-thrombotic-biomarkers-in-pancreatic-diseases-are-they-specific-of-cancer
#16
D Faille, N Ajzenberg, L de Chaisemartin, V Granger, S Chollet-Martin, E de Raucourt, P Hammel, P Lévy, P Ruszniewski, V Rebours
INTRODUCTION: Venous thrombo-embolic events (VTE) occur frequently in patients with pancreatic cancer and contribute to elevated morbidity and mortality. Clinical risk factors for thrombosis such as cancer stage and tumor grade have been clearly identified. Recently, several biomarkers have been proposed which may help identifying cancer patients at high risk of thrombosis. Those biomarkers have been studied in heterogeneous cohorts of patients with different cancer types. AIM: To compare pro-thrombotic biomarkers in pancreatic cancer and in chronic pancreatitis to determine whether these biomarkers are related to cancer or inflammation and to validate their association with thrombotic risk in a pancreatic cancer population...
April 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27025131/-gender-differences-of-the-hemostasis-postagressive-early-response-in-acute-necrotizing-pancreatitis
#17
G R Samigulina, E A Spiridonova, E V Roitman, N N Samsonova, L G Klimovich, O A Varnavin, V G Pasko, R V Makarov, M B Lagutin
The study was performed in a group of 25 patients with acute necrotizing pancreatitis (mean age 46.2 ± 6.74 years). Gender differences of the hemostasis postagressive early response in the early stages of the disease were identified by comparing the procoagulant , anticoagulant and fibrinolytic blood activity of men and women suffering from pancreatitis. Compared to men, women showed higher concentrations of fibrinogen, D-dimer and VWF and smaller values marked trombokrit , antithrombin III, inhibitor of plasmin and protein C (p < 0...
November 2015: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/26934575/predictive-capacity-of-biomarkers-for-severe-acute-pancreatitis
#18
Hanna Sternby, Hannes Hartman, Dorthe Johansen, Henrik Thorlacius, Sara Regnér
BACKGROUND: Early prediction of severe acute pancreatitis (SAP) substantially improves treatment of patients. A large amount of biomarkers have been studied with this objective. The aim of this work was to study predictive biomarkers using preset cut-off levels in an unselected population of patients with acute pancreatitis (AP). METHODS: 232 patients (52.2% males, median age 66 years) with AP admitted to Skåne University Hospital, Malmö, were consecutively enrolled...
2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/26732095/oncogenic-braf-deletions-that-function-as-homodimers-and-are-sensitive-to-inhibition-by-raf-dimer-inhibitor-ly3009120
#19
Shih-Hsun Chen, Youyan Zhang, Robert D Van Horn, Tinggui Yin, Sean Buchanan, Vipin Yadav, Igor Mochalkin, Swee Seong Wong, Yong Gang Yue, Lysiane Huber, Ilaria Conti, James R Henry, James J Starling, Gregory D Plowman, Sheng-Bin Peng
UNLABELLED: We have identified previously undiscovered BRAF in-frame deletions near the αC-helix region of the kinase domain in pancreatic, lung, ovarian, and thyroid cancers. These deletions are mutually exclusive with KRAS mutations and occur in 4.21% of KRAS wild-type pancreatic cancer. siRNA knockdown in cells harboring BRAF deletions showed that the MAPK activity and cell growth are BRAF dependent. Structurally, the BRAF deletions are predicted to shorten the β3/αC-helix loop and hinder its flexibility by locking the helix in the active αC-helix-in conformation that favors dimer formation...
March 2016: Cancer Discovery
https://www.readbyqxmd.com/read/26663012/coagulopathy-and-the-prognostic-potential-of-d-dimer-in-hyperlipidemia-induced-acute-pancreatitis
#20
COMPARATIVE STUDY
Ning Yang, Dong-Lei Zhang, Jian-Yu Hao
BACKGROUND: Coagulopathy and its association with disease severity in hyperlipidemia (HL)- and non-hyperlipidemia (NHL)-induced acute pancreatitis (AP) are not clear. The present study was to evaluate the relationship between coagulation homeostasis and AP. METHODS: This study included 106 AP patients admitted to our hospital between October 2011 and January 2013. Stratified by disease severity, the patients were divided into two groups: a mild AP (MAP) group (n=69); and a moderately severe AP (MSAP) group (n=37)...
December 2015: Hepatobiliary & Pancreatic Diseases International: HBPD INT
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