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aspartame and cancer

Lois Haighton, Ashley Roberts, Brandon Walters, Barry Lynch
The current review assessed cancer studies of aspartame based on a quality appraisal using the Klimisch grading system. Nine studies having complete histopathology were included: three 2-year studies by Searle; three transgenic mice studies by the NTP; three lifetime studies by the Ramazzini Institute. A tenth study limited to brain tumors was not rated. None were determined as Klimisch Code 1 (reliable without restrictions). The Searle studies predated GLP standards but their methodology was comparable; transgenic mouse models are not validated, but are accepted as supporting data...
January 12, 2018: Regulatory Toxicology and Pharmacology: RTP
Tao Zhang, Zhiwei Gan, Chuanzi Gao, Ling Ma, Yanxi Li, Xiao Li, Hongwen Sun
In this study, acesulfame (ACE), saccharin (SAC) and cyclamate (CYC) were found in all paired urine and blood samples collected from healthy adults, with mean values of 4070, 918 and 628 ng mL(-1), respectively, in urine and 9.03, 20.4 and 0.72 ng mL(-1), respectively, in blood. SAC (mean: 84.4 ng g(-1)) and CYC (4.29 ng g(-1)) were detectable in all liver samples collected from liver cancer patients, while ACE was less frequently detected. Aspartame (ASP) was not found in any analyzed human sample, which can be explained by the fact that this chemical metabolized rapidly in the human body...
September 14, 2016: Environmental Science. Processes & Impacts
Muthuraman Pandurangan, Gansukh Enkhtaivan, Bhupendra Mistry, Murugesan Chandrasekaran, Rafi Noorzai, Doo Hwan Kim
Aspartame is an artificial sweetener used as an alternate for sugar in several foods and beverages. The study reports that consumption of aspartame containing product could lead to cancer. However, the effect of aspartame on apoptosis process in cancer is not yet understood clearly. HeLa cells were exposed to different concentrations (0.01-0.05 mg/ml) of aspartame for 48 h. Cytotoxicity of aspartame on cancer cells was determined by SRB assay. The result indicates no significant changes on cell viability...
July 2016: Saudi Journal of Biological Sciences
Andrea Lugasi
Nowadays low calorie or intesive sweeteners are getting more and more popular. These sweeteners can be placed to the market and used as food additives according to the recent EU legislation. In the meantime news are coming out one after the other stating that many of these artificial intensive sweeteners can cause cancer - the highest risk has been attributed to aspartam. Low calorie sweeteners, just like all the other additives can be authorized after strickt risk assessment procedure according to the recent food law...
April 2016: Orvosi Hetilap
Moreno Paolini, Fabio Vivarelli, Andrea Sapone, Donatella Canistro
For the first time, the aspartame case shows how a corporation decided to ban an artificial ingredient in the wake of public opinion notwithstanding the regulatory assurance claims that it is safe. PepsiCo Inc. made an unprecedented decision most likely based on life-span carcinogenicity bioassay studies from the Cesare Maltoni Cancer Research Center of the Ramazzini Institute (CMCRC/RI), which provide consistent evidence of aspartame's carcinogenicity in rodents. Although CMCRC/RI experiments have been criticized for not complying with Organisation for Economic Co-operation and Development (OECD) guidelines, the newly launched aspartame-free soft drink may not be an isolated case...
December 7, 2017: Carcinogenesis
Abolfazl Aslani, Alireza Ghannadi, Razieh Raddanipour
BACKGROUND: Aloe vera has antioxidant, antiinflammatory, healing, antiseptic, anticancer and antidiabetic effects. The aim of the present study was to design and evaluate the formulation of Aloe vera chewing gum with an appropriate taste and quality with the indications for healing oral wounds, such as lichen planus, mouth sores caused by cancer chemotherapy and mouth abscesses as well as reducing mouth dryness caused by chemotherapy. MATERIALS AND METHODS: In Aloe vera powder, the carbohydrate content was determined according to mannose and phenolic compounds in terms of gallic acid...
2015: Advanced Biomedical Research
Da-Wu Zeng, Jing Dong, Jie-Min Zhang, Yue-Yong Zhu, Jia-Ji Jiang, Yu-Rui Liu
AIM: To investigate the prevalence and characteristics of hepatitis B e antigen (HBeAg) negative/treatment naïve subjects with low hepatitis B virus (HBV) DNA levels (<10(4)  copies/ml) and low alanine aminotransferase (ALT) levels (<2 × upper limit of normal) in patients with HBV-related hepatocellular carcinoma (HCC). METHODS: A total of 226 treatment naïve patients diagnosed with HBV-related HCC, divided into five Barcelona Clinic Liver Cancer (BCLC) stages, were enrolled and retrospectively analyzed...
October 2015: Journal of Medical Virology
Chiara Di Meo, Felisa Cilurzo, Mariano Licciardi, Cinzia Scialabba, Rocchina Sabia, Donatella Paolino, Donatella Capitani, Massimo Fresta, Gaetano Giammona, Claudio Villani, Pietro Matricardi
PURPOSE: To synthesize a new polymeric prodrug based on α,β-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-d,l-aspartamide copolymer bearing amine groups in the side chain (PHEA-EDA), covalently linked to the anticancer drug doxorubicin and to test its potential application in anticancer therapy. METHODS: The drug was previously derivatized with a biocompatible and hydrophilic linker, leading to a doxorubicin derivative highly reactive with amino groups of PHEA-EDA...
May 2015: Pharmaceutical Research
Marjorie L McCullough, Lauren R Teras, Roma Shah, W Ryan Diver, Mia M Gaudet, Susan M Gapstur
BACKGROUND: Concern about the carcinogenic potential of aspartame was raised after an increase in lymphomas and leukemia was reported in an animal study at doses similar to human exposure. Two prospective cohort studies published after the report found inconsistent results for estimated aspartame intake, artificially sweetened beverage consumption, and risk of lymphoid neoplasms. OBJECTIVE: The objective of this study was to examine associations of artificially and sugar-sweetened carbonated beverage consumption (for comparison) and aspartame intake with risk of non-Hodgkin lymphoma (NHL) overall and by major histologic subtype in the Cancer Prevention Study-II Nutrition Cohort...
December 2014: Journal of Nutrition
Armorel Diane van Eyk
CONTEXT: Artificial sweeteners (AS) have been associated with tumor development (including colon cancer) in both animals and humans although evidence has been conflicting. OBJECTIVES: Additional research was thus conducted by studying the effects of 5 AS on the morphology, cell proliferation and DNA in cells by utilizing Caco-2, HT-29 (colon) and HEK-293 (kidney) cell lines. MATERIALS AND METHODS: Cells were exposed to sodium cyclamate, sodium saccharin, sucralose and acesulfame-K (0-50 mM) and aspartame (0-35 mM) over 24, 48 and 72 hours...
2015: Drug and Chemical Toxicology
Sreekanth Mallikarjun, Rebecca McNeill Sieburth
Aspartame (APM) is the most commonly used artificial sweetener and flavor enhancer in the world. There is a rise in concern that APM is carcinogenic due to a variation in the findings of the previous APM carcinogenic bioassays. This article conducts a meta-analytic review of all previous APM carcinogenic bioassays on rodents that were conducted before 31 December 2012. The search yielded 10 original APM carcinogenic bioassays on rodents. The aggregate effect sizes suggest that APM consumption has no significant carcinogenic effect in rodents...
2015: Archives of Environmental & Occupational Health
Rod Bilton
How have climate change and diet shaped the evolution of human energy metabolism, and responses to vitamin C, fructose and uric acid? Through the last three millennia observant physicians have noted the association of inappropriate diets with increased incidence of obesity, heart disease, diabetes and cancer, and over the past 300 years doctors in the UK observed that overeating increased the incidence of these diseases. Anthropological studies of the Inuit culture in the mid-nineteenth century revealed that humans can survive and thrive in the virtual absence of dietary carbohydrate...
2013: Science Progress
Alzbeta Kamenickova, Michaela Pecova, Petr Bachleda, Zdenek Dvorak
Food constituents may cause a phenomenon of food-drug interactions. In the current study, we examined the effects of artificial sweeteners (aspartame, acesulfame, cyclamate, saccharin) on the aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)-dependent expression of CYP1A1 in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cell lines. Sweeteners were tested in concentrations up to those occurring in non-alcoholic beverages. Basal and ligand-inducible AhR- and GR-dependent reporter gene activation in stably transfected HepG2 and HeLa cells, respectively, were not affected by either of the sweeteners tested after 24h of incubation...
December 2013: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Alec L Meleger, Cameron Kiely Froude, Joseph Walker
OBJECTIVE: To assess eating behavior and nutrient intake in a group of patients who were diagnosed with chronic pain and received long-term opioid analgesic therapy. DESIGN: A descriptive, exploratory study with a convenience sample. SETTING: An outpatient pain rehabilitation center. PARTICIPANTS: Patients diagnosed with chronic pain who received long-term opioid analgesic therapy (N = 50). MAIN OUTCOME MEASUREMENTS: Body mass index, the Food Frequency Questionnaire developed by the Nutrition Assessment Shared Resource of Fred Hutchinson Cancer Research Center, and the Eating Behavior Inventory...
January 2014: PM & R: the Journal of Injury, Function, and Rehabilitation
Marina Marinovich, Corrado L Galli, Cristina Bosetti, Silvano Gallus, Carlo La Vecchia
Aspartame is a synthetic sweetener that has been used safely in food for more than 30 years. Its safety has been evaluated by various regulatory agencies in accordance with procedures internationally recognized, and decisions have been revised and updated regularly. The present review summarizes the most relevant conclusions of epidemiological studies concerning the use of low-calorie sweeteners (mainly aspartame), published between January 1990 and November 2012. In the Nurses' Health study and the Health Professionals Followup study some excess risk of Hodgkin lymphoma and multiple myeloma was found in men but not in women; no association was found with leukemia...
October 2013: Food and Chemical Toxicology
Yoshiaki Omura, Marilyn Jones, Harsha Duvvi, Kamila Paluch, Yasuhiro Shimotsuura, Motomu Ohki
Sterilizing the pre-cancer skin of malignant melanoma (M.M.) with 70% Isopropyl alcohol intensified malignancy & the malignant response extended to surrounding normal looking skin, while sterilizing with 80% (vodka) or 12% (plum wine) ethyl alcohol completely inhibited M.M. in the area (both effects lasted for about 90 minutes initially). Burnt food (bread, vegetables, meat, and fish), a variety of smoked & non-smoked fish-skin, many animal's skin, pepper, Vitamin C over 75 mg, mango, pineapple, coconut, almond, sugars, Saccharine & Aspartame, garlic, onion, etc & Electromagnetic field from cellular phones worsened M...
2013: Acupuncture & Electro-therapeutics Research
Dagfinn Aune
No abstract text is available yet for this article.
December 2012: American Journal of Clinical Nutrition
Eva S Schernhammer, Kimberly A Bertrand, Brenda M Birmann, Laura Sampson, Walter C Willett, Diane Feskanich
BACKGROUND: Despite safety reports of the artificial sweetener aspartame, health-related concerns remain. OBJECTIVE: We prospectively evaluated whether the consumption of aspartame- and sugar-containing soda is associated with risk of hematopoetic cancers. DESIGN: We repeatedly assessed diet in the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS). Over 22 y, we identified 1324 non-Hodgkin lymphomas (NHLs), 285 multiple myelomas, and 339 leukemias...
December 2012: American Journal of Clinical Nutrition
Morando Soffritti, Fiorella Belpoggi, Marco Manservigi, Eva Tibaldi, Michelina Lauriola, Laura Falcioni, Luciano Bua
BACKGROUND: Aspartame (APM) is a well-known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague-Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and that its effects are increased when exposure starts from prenatal life. OBJECTIVE: The aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice...
December 2010: American Journal of Industrial Medicine
Cécilia Cabaniols, Roch Giorgi, Olivier Chinot, Nabila Ferahta, Valérie Spinelli, Philippe Alla, Maryline Barrie, Marie-Pascale Lehucher-Michel
Numerous studies have increasingly suggested that medical history and lifestyle factors could be involved in the increase of cancer risk in adults. The issue whether psychological factors can influence the development of cancer has been discussed for many years. In the field of brain cancer, psychological stress has not so far been investigated. We conducted a French case-control pilot study with 122 adult incident cases and 122 controls free of any cancer diagnosis, matched for age and gender, to investigate links between malignant primitive brain tumours (MPBT) and medical history, private habits and psychological stress...
June 2011: Journal of Neuro-oncology
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