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https://www.readbyqxmd.com/read/28749264/pulmonary-lesions-caused-by-the-lungworm-didelphostrongylus-hayesi-in-the-opossum-didelphis-virginiana-in-colima-mexico
#1
Rubén A López-Crespo, Alfonso López-Mayagoitia, Rafael Ramírez-Romero, Julio Martínez-Burnes, Omar F Prado-Rebolledo, Luis J García-Márquez
Didelphostrongylus hayesi is an important and prevalent pulmonary nematode in the opossum ( Didelphis virginiana ). An in-depth description of the pulmonary lesions caused by this nematode is lacking. The objective of this investigation was to make a detailed account of the gross, subgross, and microscopic changes that occur in the lungs of opossums naturally infected with D. hayesi. Forty-four opossums trapped in the state of Colima, Mexico, were euthanized by an overdose of barbiturates. Following a postmortem examination, the right lung was cut from the main bronchi and placed in a Petri dish containing a saline solution for the detection and identification of live parasites...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28748646/small-airway-dysfunction-in-chronic-hypersensitivity-pneumonitis
#2
Selene Guerrero Zúñiga, Julia Sánchez Hernández, Heidegger Mateos Toledo, Mayra Mejía Ávila, Laura Gochicoa-Rangel, José Luis Miguel Reyes, Moisés Selman, Luis Torre-Bouscoulet
BACKGROUND AND OBJECTIVE: Lung biopsies from patients with hypersensitivity pneumonitis (HP) have demonstrated small airway (SA) involvement, but there is no information concerning SA function in HP, and it is unknown whether pharmacological treatment could modify its function. SA function in patients with chronic HP using ultrasonic pneumography (UPG) and impulse oscillometry (IOS) was explored. We also compared initial results with those obtained after 4 weeks of standardized treatment with azathioprine and prednisone...
July 26, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28747414/muscular-sarcocystosis-an-index-case-in-a-native-malaysian
#3
Nurashikin Mohammad, Alwi Muhd Besari, Pradeep Kumar Nair, Wan Syamimee Wan Ghazali
A previously healthy 20-year-old man presented with prolonged intermittent low grade fever and cough for 6months. He had bilateral calf pain and lower limb weakness 2days prior to admission. Physical examination revealed multiple enlarged lymph nodes with hepatomegaly. There was bilateral calf tenderness with evidence of proximal myopathy. Full blood picture showed lymphocytosis with reactive lymphocytes and eosinophilia. Creatine kinase and lactate dehydrogenase were markedly elevated. Over 2 weeks of admission, patient was treated symptomatically until the muscle biopsy of right calf revealed eosinophilic myositis with muscular sarcocystosis...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28746917/cytological-features-of-the-large-cell-variant-of-small-cell-ovarian-carcinoma-in-young-patients-with-hypercalcemia-histological-findings-and-review-of-the-literature
#4
Helen J Trichia, Paraskevi Tziakou, Dimitrios C Papatheodorou, Joanna Lekka
OBJECTIVE: To present the cytological features of a very rare and lethal ovarian neoplasm occurring in the young. STUDY DESIGN: We reviewed the cytological findings as they presented in touch imprints obtained from an ovarian mass sent to our department for frozen section investigation. RESULTS: Smears were highly cellular. The cells were of intermediate size with a moderate amount of microvacuolated, pale, or eosinophilic cytoplasm with indistinct cell borders...
July 27, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28746218/localized-nasopharyngeal-amyloidosis-mimicking-malignancy-a-case-report
#5
Jong Seung Kim, Sam Hyun Kwon
RATIONALE: Nasopharyngeal amyloidosis is a benign, slowly progressive disease that is characterized by extracellular eosinophilic deposition. PATIENT CONCERNS: We report a rare case of localized nasopharyngeal amyloidosis. DIAGNOSES: The initial chief complaint of this patient was frequent epistaxis and right aural fullness. The initial diagnosis was nasopharyngeal tumor. INTERVENTIONS: There is no universally effective medical treatment for nasopharyngeal amyloidosis but surgery can be an option...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745828/incidence-of-eosinophilic-esophagitis-in-the-netherlands-continues-to-rise-20-year-results-from-a-nationwide-pathology-database
#6
M J Warners, W de Rooij, B D van Rhijn, J Verheij, A H Bruggink, A J P M Smout, A J Bredenoord
BACKGROUND: The incidence of eosinophilic esophagitis (EoE) has increased rapidly. Most epidemiologic data were gathered in single-center studies over a short timeframe, possibly explaining the heterogeneous incidences. AIM: The aim of this study was to retrospectively estimate the Dutch nationwide incidence of EoE over the last 20 years. METHODS: The Dutch pathology registry (PALGA) was queried to identify pathology reports describing esophageal eosinophilia from 1996 to 2016...
July 26, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28743424/blood-eosinophil-to-basophil-ratio-in-patients-with-sinonasal-polyps-does-it-have-a-clinical-role
#7
Giuseppe Brescia, Umberto Barion, Claudia Zanotti, Francesco Cinetto, Luciano Giacomelli, Alessandro Martini, Gino Marioni
BACKGROUND: In a recent preliminary study, eosinophil and basophil counts were calculated in chronic rhinosinusitis with nasal polyps (CRSwNP) using conventional histologic and immunohistochemical methods. The tissue eosinophil-to-basophil ratio differed in the CRSwNP endotypes considered. OBJECTIVE: To compare the blood eosinophil-to-basophil ratio (bEBR) in a large series of patients with CRSwNP with that in a control group of consecutive rhinological patients with no evidence of nasal, paranasal, or systemic inflammatory disorders...
July 22, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28743303/multiorgan-eosinophilic-infiltration-after-initiation-of-clozapine-therapy-a-case-report
#8
Dorota Marchel, Anita L Hart, Patricia Keefer, Jennifer Vredeveld
BACKGROUND: The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction. CASE PRESENTATION: In this case report, we describe a 24 year old Caucasian male who presented with severe systemic eosinophilia resulting in eosinophilic GI tract infiltration, myocarditis, pericardial and pleural effusions with dramatic improvement following drug withdrawal...
July 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28743127/a-rare-presentation-of-immunoglobulin-a-nephropathy-acute-kidney-injury
#9
Meric Oruc, Haydar Durak, Serkan Feyyaz Yalin, Nurhan Seyahi, Mehmet Rıza Altıparmak, Sinan Trabulus
BACKGROUND: Acute kidney injury (AKI) is known as an uncommon presentation in immunoglobulin A nephropathy (IgAN). The aim of our study was to analyze the clinical data and biopsy findings in IgAN patients presenting with AKI. METHODS: We performed a retrospective analysis of all subjects who had biopsy-proven IgAN and presented with AKI during June 2002 September 2015. The following data were obtained from medical records. RESULTS: A total of 15 patients of 123 patients (12...
July 26, 2017: Nephron
https://www.readbyqxmd.com/read/28742240/role-of-tissue-eosinophils-in-chronic-rhinosinusitis-associated-olfactory-loss
#10
Leah J Hauser, Rakesh K Chandra, Ping Li, Justin H Turner
BACKGROUND: Olfactory dysfunction is 1 of the hallmark symptoms of chronic rhinosinusitis (CRS). Eosinophilic inflammation has been implicated as a potential causative factor. However, prior studies have been limited by retrospective study designs, concomitant use of systemic corticosteroids, and other confounding factors. METHODS: CRS and healthy non-CRS control subjects undergoing endoscopic sinus or skull-base surgery were prospectively enrolled and completed olfactory testing utilizing the 40-item Smell Identification Test (SIT) immediately prior to surgery...
July 25, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28742120/virus-induced-asthma-attack-the-importance-of-allergic-inflammation-in-response-to-viral-antigen-in-an-animal-model-of-asthma
#11
Christopher Skappak, Ramses Ilarraza, Ying-Qi Wu, Matthew G Drake, Darryl J Adamko
Asthma exacerbation can be a life-threatening condition, and is most often triggered by common respiratory viruses. Poor asthma control and worsening of respiratory function is associated with increased airway inflammation, including eosinophilia. Prevention of asthma exacerbation relies on treatment with corticosteroids, which preferentially inhibit allergic inflammation like eosinophils. Human studies demonstrate that inactivated virus can trigger eosinophil activation in vitro through antigen presentation and memory CD4+ lymphocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28742098/pathological-manifestations-in-lymphatic-filariasis-correlate-with-lack-of-inhibitory-properties-of-igg4-antibodies-on-ige-activated-granulocytes
#12
Ulrich F Prodjinotho, Charlotte von Horn, Alex Y Debrah, Linda Batsa Debrah, Anna Albers, Laura E Layland, Achim Hoerauf, Tomabu Adjobimey
Helminth parasites are known to be efficient modulators of their host's immune system. To guarantee their own survival, they induce alongside the classical Th2 a strong regulatory response with high levels of anti-inflammatory cytokines and elevated plasma levels of IgG4. This particular antibody was shown in different models to exhibit immunosuppressive properties. How IgG4 affects the etiopathology of lymphatic filariasis (LF) is however not well characterized. Here we investigate the impact of plasma and affinity-purified IgG/IgG4 fractions from endemic normals (EN) and LF infected pathology patients (CP), asymptomatic microfilaraemic (Mf+) and amicrofilaraemic (Mf-) individuals on IgE/IL3 activated granulocytes...
July 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28741505/emerging-roles-for-eosinophils-in-the-tumor-microenvironment
#13
REVIEW
Hadar Reichman, Danielle Karo-Atar, Ariel Munitz
Eosinophils are evolutionary conserved cells largely studied in the context of allergy. Although eosinophils were first described in tumors more than 120 years ago, their roles in cancer are often overlooked. This is puzzling given their potent immune modulatory, cytotoxic, and/or tissue repair capabilities, and recent studies demonstrating key roles for eosinophils in contexts far beyond their 'classical' field (e.g., metabolism, thermogenesis, and tissue regeneration). Recent data suggest that this frequently ignored cell is emerging as a potent immune effector and immune modulator in the tumor microenvironment...
November 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28739021/single-and-multiple-food-allergies-in-infants-with-proctocolitis
#14
B T Koksal, Z Barıs, F Ozcay, O Yilmaz Ozbek
BACKGROUND: Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined. OBJECTIVE: This study aimed to identify characteristics of infants with proctocolitis and compare infants with single and multiple food allergies. METHODS: A total of 132 infants with proctocolitis were evaluated retrospectively. All of the infants were diagnosed by a paediatric allergist and/or a paediatric gastroenterologist according to guidelines...
July 21, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28737966/effect-of-obesity-on-sinonasal-disease-in-asthma
#15
S Kanagalingam, S S Shehab, D A Kaminsky, R A Wise, J E Lang, A E Dixon
Sinonasal disease can contribute to poor asthma control. There are reports that link obesity with an increased prevalence of sinonasal disease, but no studies evaluating the severity of sinonasal disease in obese asthmatics, and how this impacts asthma control. The purpose of the current study was to determine if obesity is associated with increased severity of sinonasal disease, and/or affects response to nasal corticosteroid treatment in asthma. METHODS: This study included 236 adults participating in a 24-week randomized, double-masked, placebo-controlled study of nasal mometasone for the treatment of poorly controlled asthma...
July 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28737932/ins-and-outs-in-environmental-and-occupational-safety-studies-of-asthma-and-engineered-nanomaterials
#16
Marina A Dobrovolskaia, Michael R Shurin, Valerian E Kagan, Anna A Shvedova
According to the Centers for Disease Control and Prevention, approximately 25 million Americans suffer from asthma. The disease total annual cost is about $56 billion and includes both the direct and indirect costs of medications, hospital stays, missed work, and decreased productivity. Air pollution with xenobiotics, bacterial agents, and industrial nanomaterials, such as carbon nanotubes, contribute to the exacerbation of this condition and are a point of particular attention in environmental toxicology as well as in occupational health and safety research...
July 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28737861/effects-of-25-hydroxy-vitamin-d-levels-on-the-severity-and-asthma-control-in-school-age-asthma-patients
#17
Merve Havan, Cem H Razi, Ayse D Bulus, Ali O Köksal, Nesibe Andıran
BACKGROUND: The objective was to determine vitamin D levels in patients between the ages 6 and 18 years, followed for asthma, and the relation between vitamin D levels and asthma control and severity. MATERIALS AND METHODS: Patients with asthma and healthy volunteers between the ages 6 and 18 years were enrolled into the study as patient and control groups, respectively. Patient demographic information and clinical findings were recorded; a respiratory function test was performed...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737158/gastric-lesions-in-dolphins-stranded-along-the-eastern-adriatic-coast
#18
Jerko Hrabar, Ivana Bočina, Andrea Gudan Kurilj, Martina Đuras, Ivona Mladineo
Stranded cetaceans are often found with gastric lesions associated with the presence of parasites; most frequently, nematodes of the genus Anisakis and the heterophyd digenean trematode Pholeter gastrophilus. In this study, we present histopathology mainly (but not exclusively) related to these 2 parasite species. Macroscopically, lesions associated with the presence of Anisakis spp. were characterised by the presence of ulcers within the gastric mucosa, while the digenean P. gastrophilus was found within large submucosal fibrotic nodules in the gastric wall...
July 24, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28737051/pharmacokinetic-pharmacodynamic-drug-evaluation-of-benralizumab-for-the-treatment-of-asthma
#19
Maria Gabriella Matera, Luigino Calzetta, Barbara Rinaldi, Mario Cazzola
In many severe asthmatics, eosinophils cause inflammation and airways hyperresponsiveness, resulting in frequent exacerbations, impaired lung function, and reduced quality of life. Interleukin-5 (IL-5) is a key cytokine for eosinophil growth, differentiation, recruitment, activation, and survival. Anti-IL-5-based therapies (mepolizumab and reslizumab are humanized monoclonal antibodies (hmAbs) that recognize free IL-5, benralizumab is a hmAb directed at the α subunit of the IL-5R) target the IL-5-signaling in eosinophilic asthma...
July 24, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28736997/distinct-histopathologic-features-of-radiation-induced-chronic-sinusitis
#20
Hannah N Kuhar, Bobby A Tajudeen, Ashley Heilingoetter, Mahboobeh Mahdavinia, Paolo Gattuso, Ritu Ghai, Ferry Gunawan, Aidnag Z Diaz, George Tolekidis, Pete S Batra
BACKGROUND: Chronic rhinosinusitis (CRS) is a commonly observed sequela after radiation therapy to the paranasal sinuses. The histopathologic features of radiation-induced CRS have yet to be determined and may have major implications in disease management. METHODS: A structured histopathology report was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). Histopathology variables, Lund-Mackay score (LMS), and 22-item Sino-Nasal Outcome Test (SNOT-22) scores were compared among patients with radiation-induced CRS (CRSr), CRS without nasal polyps (CRSsNP), and CRS with nasal polyps (CRSwNP)...
July 24, 2017: International Forum of Allergy & Rhinology
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