Rui Yang, Wei He, Changxin Zhu, Xifeng Yang, Yawei Kuang, Tao Zhu, Jingyang Xu, Yuang Zhao, Tingwang Jiang, Yushen Liu, Mengmeng Wei
BACKGROUND: Mitophagy plays indispensable roles in maintaining intracellular homeostasis in most eukaryotic cells by selectively eliminating superfluous components or damaged organelles. Thus, the co-operation of mitochondrial probes and lysosomal probes was presented to directly monitor mitophagy in dual colors. Nowadays, most of the lysosomal probes are composed of groups sensitive to pH, such as morpholine, amine and other weak bases. However, the pH in lysosomes would fluctuate in the process of mitophagy, leading to the optical interference...
May 8, 2024: Analytica Chimica Acta