Aamir Jeewa, Ashok Kumar Manickaraj, Luc Mertens, Cedric Manlhiot, Caroline Kinnear, Tapas Mondal, John Smythe, Herschel Rosenberg, Jane Lougheed, Brian W McCrindle, Glen van Arsdell, Andrew N Redington, Seema Mital
BACKGROUND: Hypoxia-inducible factor (HIF1A) regulates the myocardial response to hypoxia and hemodynamic load. We investigated the association of HIF1A variants with right-ventricular (RV) remodeling after tetralogy of Fallot (TOF) repair. METHODS: Children with TOF were genotyped for three single-nucleotide polymorphisms in HIF1A. Genotypes were analyzed for association with RV myocardial protein expression and fibrosis at complete repair (n = 42) and RV dilation, fractional area change, and freedom from pulmonary valve/conduit replacement on follow-up...
October 2012: Pediatric Research