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https://www.readbyqxmd.com/read/29431168/king-devick-test-identifies-real-time-concussion-and-asymptomatic-concussion-in-youth-athletes
#1
Priya S Dhawan, Danielle Leong, Lisa Tapsell, Amaal J Starling, Steven L Galetta, Laura J Balcer, Trenton L Overall, Jennifer S Adler, Rashmi B Halker-Singh, Bert B Vargas, David Dodick
Background: Sports concussion has an annual incidence of approximately 3.8 million. Over half go unreported and a substantial number may be asymptomatic. A rapid, cost-effective, and reliable tool that facilitates diagnosis of concussion is needed. The King-Devick (K-D) test is a vision-based tool of rapid number naming for assessment of concussion. In this study, we evaluated the utility of the K-D test in real time for identification of symptomatic concussion in youth athletes and to determine if similar impairment (subclinical concussion) exists in youth athletes without an obvious head injury or symptoms...
December 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29430167/the-genetic-dissection-of-myo7a-gene-expression-in-the-retinas-of-bxd-mice
#2
Ye Lu, Diana Zhou, Rebecca King, Shuang Zhu, Claire L Simpson, Byron C Jones, Wenbo Zhang, Eldon E Geisert, Lu Lu
Purpose: Usher syndrome (US) is characterized by a loss of vision due to retinitis pigmentosa (RP) and deafness. US has three clinical subtypes, but even within each subtype, the severity varies. Myosin VIIA, coded by Myo7a, has been identified as one of the causal genes of US. This study aims to identify pathways and other genes through which Myo7a interacts to affect the presentation of US symptoms. Methods: In this study, we used the retinal tissue of BXD recombinant inbred (RI) mice to examine the expression of Myo7a and perform genetic mapping...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29428869/cross-sectional-study-to-assess-the-association-of-color-vision-with-mercury-hair-concentration-in-children-from-brazilian-amazonian-riverine-communities
#3
Joyce Dos Santos Freitas, Eliza Maria da Costa Brito Lacerda, Isabelle Christine Vieira da Silva Martins, Dario Rodrigues, Daniela Maria Oliveira Bonci, Maria Izabel Tentes Cortes, Tereza Cristina Oliveira Corvelo, Dora Fix Ventura, Luiz Carlos de Lima Silveira, Maria da Conceição Nascimento Pinheiro, Givago da Silva Souza
BACKGROUND: Mercury exposure in the Brazilian Amazon region has been an important concern since the 1980s, when gold mining activities contaminated many Amazonian river basins and the fish therein. Mercury exposure in humans can lead to changes in neural function. The visual system has been used as a functional indicator of methylmercury (organic) and mercury vapour (inorganic) toxicity. Children are particularly vulnerable to this metal exposure. OBJECTIVE: To compare the color vision of children from riverine communities of mercury-exposed (Tapajós basin) and non-exposed Amazonian rivers (Tocantins basin)...
February 8, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29411487/technique-postoperative-complications-and-visual-outcomes-of-phacoemulsification-cataract-surgery-in-21-penguins-27-eyes-2011-2015
#4
Melanie L Church, Daniel R Priehs, Heidi Denis, Lara Croft, Stacy DiRocco, Michelle Davis
OBJECTIVE: To describe surgical technique, postoperative complications, and visual outcome in penguins after phacoemulsification lens extraction surgery. ANIMALS STUDIED: Twenty-one penguins (27 eyes) that had phacoemulsification from 2011 to 2015 at Animal Eye Associates. Species included are as follows: 14 southern Rockhopper (18 eyes, 66.6%), 4 Gentoo (4 eyes, 19%), 2 King (3 eyes, 9.5%), and 1 Chinstrap penguin (2 eyes, 4.8%). Eleven of the penguins were females, and 10 were males with average age at the time of surgery being 27...
February 6, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29401210/evaluating-the-benefits-of-hospital-room-artwork-for-patients-receiving-cancer-treatment-a-randomized-controlled-trial
#5
Daniel R George, Claire de Boer, Joel Hammer, Margaret Hopkins, Tonya King, Michael J Green
We examined whether placing a painting in the line of vision of a hospitalized patient improves patient outcomes and satisfaction and whether having patients choose their paintings offers greater benefit. From 2014 to 2016, we enrolled 186 inpatients with cancer diagnoses from Pennsylvania State University Cancer Institute and randomly assigned them to 3 groups: those who chose paintings displayed in rooms, those whose paintings were randomly selected, and those with no paintings. We assessed anxiety, mood, depression, quality of life, perceptions of hospital environment, sense of control and/or influence, self-reported pain, and length of stay and compared patients with paintings versus those without paintings, as well as those with an artwork choice versus those with no choice...
February 5, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29398498/prediction-of-occult-invasive-disease-in-ductal-carcinoma-in-situ-using-deep-learning-features
#6
Bibo Shi, Lars J Grimm, Maciej A Mazurowski, Jay A Baker, Jeffrey R Marks, Lorraine M King, Carlo C Maley, E Shelley Hwang, Joseph Y Lo
PURPOSE: The aim of this study was to determine whether deep features extracted from digital mammograms using a pretrained deep convolutional neural network are prognostic of occult invasive disease for patients with ductal carcinoma in situ (DCIS) on core needle biopsy. METHODS: In this retrospective study, digital mammographic magnification views were collected for 99 subjects with DCIS at biopsy, 25 of which were subsequently upstaged to invasive cancer. A deep convolutional neural network model that was pretrained on nonmedical images (eg, animals, plants, instruments) was used as the feature extractor...
February 2, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29379335/advancing-pharmaceuticals-and-patient-safety-in-saudi-arabia-a-2030-vision-initiative
#7
Tariq M Alhawassi, Hatem A Abuelizz, Mansour Almetwazi, Mansour A Mahmoud, Ahmed Alghamdi, Yazed S Alruthia, Nasser BinDhim, Khalid A Alburikan, Yousif A Asiri, Peter J Pitts
Low-quality medicines deliver sub-optimal clinical outcomes and waste precious health resources. It is important to ensure that public funds are spent on healthcare technologies that meet national regulatory bodies such as the Saudi Food and Drug Authority (SFDA), quality standards for safety, efficacy, and quality. Medicines quality is a complicated combination of pre-market regulatory specifications, appropriate sourcing of ingredients (active pharmaceutical ingredient (API), excipients, etc.), manufacturing processes, healthcare ecosystem communications, and regular and robust pharmacovigilance practices...
January 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29376446/linking-of-assessment-scales-for-women-with-urinary-incontinence-and-the-international-classification-of-functioning-disability-and-health
#8
Thaissa Hamana de Macedo Dantas, Luciana Castaneda, Adriana Gomes Magalhães, Diego de Sousa Dantas
PURPOSE: This study aimed to link the content of four most used questionnaires to assess the quality of life of women with urinary incontinence (International Consultation on Incontinence Questionnaire; King's Health Questionnaire; Incontinence Quality of Life Questionnaire and Bristol Female Urinary Tract Symptoms Questionnaire) with the International Classification of Functioning, Disability and Health (ICF). METHODS: Linking the questionnaires content and the ICF was performed by two independent reviewers, with an excellent concordance level (k = 0...
January 29, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29328066/a-british-ophthalmological-surveillance-unit-study-on-metastatic-endogenous-endophthalmitis
#9
S Maling, C King, N Davies
PurposeEndogenous endophthalmitis (EE) is a rare but serious ocular infection caused by the seeding of bacteria into the eye from a source elsewhere in the body. Studies suggest that EE accounts for 2 to 8% of all endophthalmitis.MethodsA prospective observational study was conducted using the British Ophthalmological Surveillance Unit reporting system. Questionnaires were sent to reporting Ophthalmologists in the UK to assess incidence, underlying aetiology, eye findings, management, and final outcomes in endogenous endophthalmitis over a 12-month period within the British Isles...
January 12, 2018: Eye
https://www.readbyqxmd.com/read/29318471/aav-mediated-gene-delivery-of-the-calreticulin-anti-angiogenic-domain-inhibits-ocular-neovascularization
#10
Leilei Tu, Jiang-Hui Wang, Veluchamy A Barathi, Selwyn M Prea, Zheng He, Jia Hui Lee, James Bender, Anna E King, Grant J Logan, Ian E Alexander, Youn-Shen Bee, Ming-Hong Tai, Gregory J Dusting, Bang V Bui, Jingxiang Zhong, Guei-Sheung Liu
Ocular neovascularization is a common pathological feature in diabetic retinopathy and neovascular age-related macular degeneration that can lead to severe vision loss. We evaluated the therapeutic efficacy of a novel endogenous inhibitor of angiogenesis, the calreticulin anti-angiogenic domain (CAD180), and its functional 112-residue fragment, CAD-like peptide 112 (CAD112), delivered using a self-complementary adeno-associated virus serotype 2 (scAAV2) in rodent models of oxygen-induced retinopathy and laser-induced choroidal neovascularization...
January 9, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29279655/outcomes-of-pneumatic-retinopexy-for-the-management-of-rhegmatogenous-retinal-detachment-at-a-tertiary-care-center
#11
Mohammad A Hazzazi, Saba Al Rashaed
PURPOSE: The purpose of the study was to report the outcomes of pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RRD). METHODS: A retrospective chart review of all patients with RRD who were managed with PR at the King Khaled Eye Specialist Hospital between 2000 and 2014. Data were collected on preoperative ocular history, characteristics of the RRD, postoperative anatomical and visual outcomes, and secondary surgeries. RESULTS: Sixty-five eyes comprised the study sample with mean a follow-up of 42 months...
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29241100/the-effect-of-spatial-auditory-landmarks-on-ambulation
#12
Adham M Karim, Kavelin Rumalla, Laurie A King, Timothy E Hullar
The maintenance of balance and posture is a result of the collaborative efforts of vestibular, proprioceptive, and visual sensory inputs, but a fourth neural input, audition, may also improve balance. Here, we tested the hypothesis that auditory inputs function as environmental spatial landmarks whose effectiveness depends on sound localization ability during ambulation. Eight blindfolded normal young subjects performed the Fukuda-Unterberger test in three auditory conditions: silence, white noise played through headphones (head-referenced condition), and white noise played through a loudspeaker placed directly in front at 135 centimeters away from the ear at ear height (earth-referenced condition)...
December 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29184605/the-risk-of-ischemic-optic-neuropathy-post-phacoemulsification-cataract-surgery
#13
Mousa Victor Al-Madani, Nancy Khalaf Al-Raqqad, Naser Abdallah Al-Fgarra, Amal Mousa Al-Thawaby, Ahmed Abdelra'of Jaafar
Introduction: The aim was to study the risk of non arteritic ischemic optic neuropathy after phacoemulsification cataract surgery. Methods: This study was conducted at King Hussein Medical Center during the period between January 2015 and July 2016. Patients attending ophthalmology clinic complaining of decreased vision due to lens opacity were evaluated. Patients were divided into two groups. First group included patients with no medical illness and second group included patients with diabetes mellitus, hypertension or hyperlipidemia...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29114192/optic-neuritis-observation-and-experience-at-a-tertiary-care-hospital-in-qassim-region-saudi-arabia
#14
Mohammad Jawad Alamgir, Syed Abrar Ali, Nermin Aly Hamdy, Moin Zafar Khan, Elgamri E Mohammad
Objectives: Optic neuritis (ON) can occur in isolation or association with multiple sclerosis (MS) or neuromyelitis optica. ON, is seen more commonly in Caucasians and interaction is found to exist between ethnic origin and the latitude at which the patient grows up. At present limited information is available about the profile of ON in Saudi patients. We aimed to analyze the records of ON patients, in regard to their presentation, natural history, treatment outcome, and risk and association with MS...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29110885/the-nih-science-of-behavior-change-program-transforming-the-science-through-a-focus-on-mechanisms-of-change
#15
Lisbeth Nielsen, Melissa Riddle, Jonathan W King, Will M Aklin, Wen Chen, David Clark, Elaine Collier, Susan Czajkowski, Layla Esposito, Rebecca Ferrer, Paige Green, Christine Hunter, Karen Kehl, Rosalind King, Lisa Onken, Janine M Simmons, Luke Stoeckel, Catherine Stoney, Lois Tully, Wendy Weber
The goal of the NIH Science of Behavior Change (SOBC) Common Fund Program is to provide the basis for an experimental medicine approach to behavior change that focuses on identifying and measuring the mechanisms that underlie behavioral patterns we are trying to change. This paper frames the development of the program within a discussion of the substantial disease burden in the U.S. attributable to behavioral factors, and details our strategies for breaking down the disease- and condition-focused silos in the behavior change field to accelerate discovery and translation...
July 6, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29074496/treatment-of-advanced-glaucoma-study-a-multicentre-randomised-controlled-trial-comparing-primary-medical-treatment-with-primary-trabeculectomy-for-people-with-newly-diagnosed-advanced-glaucoma-study-protocol
#16
Anthony J King, Gordon Fernie, Augusto Azuara-Blanco, Jennifer M Burr, Ted Garway-Heath, John M Sparrow, Luke Vale, Jemma Hudson, Graeme MacLennan, Alison McDonald, Keith Barton, John Norrie
BACKGROUND: Presentation with advanced glaucoma is the major risk factor for lifetime blindness. Effective intervention at diagnosis is expected to minimise risk of further visual loss in this group of patients. AIM: To compare clinical and cost-effectiveness of primary medical management compared with primary surgery for people presenting with advanced open-angle glaucoma (OAG). METHODS: Design: A prospective, pragmatic multicentre randomised controlled trial (RCT)...
October 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29056498/a-comparison-of-3-videolaryngoscopes-for-double-lumen-tube-intubation-in-humans-by-users-with-mixed-experience-a-randomized-controlled-study
#17
Mohamed R El-Tahan, Alaa M Khidr, Ihab S Gaarour, Saeed A Alshadwi, Talal M Alghamdi, Abdulmohsen Al'ghamdi
OBJECTIVES: To test the hypothesis that laryngoscopy using the Airtraq (Prodol Limited, Viscaya, Spain) or King Vision laryngoscope (KVL) (Ambu A/S, Ballerup, Denmark) would result in a shorter time for successful double-lumen endobronchial tube (DLT) intubation by users with mixed experience than the time required using the Macintosh or GlideScope (Verathon Inc., Bothell, WA) laryngoscopes. DESIGN: A randomized, prospective, blind study. SETTING: A single university hospital...
August 4, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29044062/changing-epidemiology-of-neovascular-glaucoma-from-2002-to-2012-at-king-khaled-eye-specialist-hospital-saudi-arabia
#18
Abdullah Al-Bahlal, Rajiv Khandekar, Khalid Al Rubaie, Tariq Alzahim, Deepak P Edward, Igor Kozak
PURPOSE: The aim is to present the incidence and determinants of neovascular glaucoma (NVG) in Saudi Arabia. METHODS: A retrospective review of NVG cases (2002-2012) was included to estimate the incidence. The determinants included gender, age, comorbidities, lens status, type of NVG, and visual acuity on presentation. The impact of antiangiogenic therapy on NVG incidence was studied. RESULTS: We studied 597 eyes with NVG. The incidence was 6...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29028240/tobacco-still-a-major-killer-will-we-achieve-the-end-game
#19
Luis Saboga-Nunes, Diane Levin-Zamir, Vance Rabius
The game of tobacco use began in Europe in 1560 when the first tobacco seeds were sent from Lisbon to the king of France, by Jean Nicot. From kings' and nobles' exclusive use, it gradually and progressively became popular among the public, as a new player. Eighty-eight years ago (1929), Fritz Linkint, an extraordinary researcher in Germany, while reviewing existing evidence regarding a wide range of cancers potentially caused by smoking, indicated that smoking was a cause of respiratory disease. Despite the overwhelming accumulated evidence of the negative effects of nicotine intake, the prevalence of tobacco use is not expected to decline in the near future...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28900564/relationships-among-common-vision-and-vestibular-tests-in-healthy-recreational-athletes
#20
John D Heick, Curt Bay, Thomas P Dompier, Tamara C Valovich McLeod
BACKGROUND: Disruption of the visual and vestibular systems is commonly observed following concussion. Researchers have explored the utility of screening tools to identify deficits in these systems in concussed patients, but it is unclear if these tests are measuring similar or distinct phenomena. PURPOSE: To determine the relationships between common vestibular tests including the King-Devick (K-D) test, Sensory Organization Test (SOT), Head Shake-Sensory Organization Test (HS-SOT), and Dynamic Visual Acuity (DVA) test, when administered contiguously, to healthy recreational athletes aged 14 to 24 years...
August 2017: International Journal of Sports Physical Therapy
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