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https://www.readbyqxmd.com/read/28227633/beacon-based-opportunistic-scheduling-in-wireless-body-area-network
#1
Yang Zhou, Zhengguo Sheng, Victor C M Leung, Peyman Servati, Yang Zhou, Zhengguo Sheng, Victor C M Leung, Peyman Servati, Yang Zhou, Zhengguo Sheng, Victor C M Leung, Peyman Servati
Wireless Body Area Networks (WBANs) are one of the key technologies that support the development of digital health care, which has attracted increasing attention in recent years. Compared with general Wireless Sensor Networks (WSNs), WBANs have more stringent requirements on reliability and energy efficiency. Though WBANs are applied within limited transmission range, the on-body channel condition can be very challenging because of blocking or absorbing of signal. In this paper, we are looking into the design of Medium Access Control (MAC) protocols and propose an opportunistic scheduling scheme by applying heuristic scheduling and dynamic superframe length adjustment to improve the system performance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225718/frailty-and-circulating-markers-of-inflammation-in-hiv-and-hiv-men-in-the-multicenter-aids-cohort-study
#2
Joseph B Margolick, Jay H Bream, Otoniel Martínez-Maza, Joe Lopez, Xiuhong Li, John P Phair, Susan L Koletar, Lisa P Jacobson
BACKGROUND: Frailty is associated with immune activation and inflammation in the elderly general population, but whether this is true in the younger HIV-infected (HIV+) population is not known. METHODS: We analyzed 24 serologic biomarkers of monocyte, T-cell, or B-cell activation in HIV- (n = 207) and HIV+ (n = 714; 75% virologically suppressed) men who have sex with men in the Multicenter AIDS Cohort Study (MACS) and were classified as frail or nonfrail according to expression or nonexpression of the frailty phenotype at 2 consecutive study visits...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28223983/b-cell-homeostasis-and-functional-properties-are-altered-in-an-hypochlorous-acid-induced-murine-model-of-systemic-sclerosis
#3
Sébastien Sanges, Manel Jendoubi, Niloufar Kavian, Carine Hauspie, Silvia Speca, Jean-Charles Crave, Thomas Guerrier, Guillaume Lefèvre, Vincent Sobanski, Ariel Savina, Eric Hachulla, Pierre-Yves Hatron, Myriam Labalette, Frédéric Batteux, Sylvain Dubucquoi, David Launay
INTRODUCTION: During systemic sclerosis (SSc), peripheral B cells display alterations in subset homeostasis and functional properties and are a promising therapeutic target. However, there is only few data regarding whether these anomalies are accurately reproduced in animal models of SSc. OBJECTIVE: In this work, we assessed the B cell homeostasis modifications in an experimental model of SSc [hypochlorous acid (HOCl)-induced mouse], both at a phenotypic and functional level, during the course of the disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28221766/proteoform-profile-mapping-of-the-human-serum-complement-component-c9-reveals-unexpected-new-features-of-n-o-and-c-glycosylation
#4
Vojtech Franc, Yang Yang, Albert J R Heck
The human complement C9 protein (~65 kDa) is a member of the complement pathway. It plays an essential role in the membrane attack complex (MAC), which forms a lethal pore on the cellular surface of pathogenic bacteria. Here, we charted in detail the structural micro-heterogeneity of C9 purified from human blood serum, using an integrative workflow combining high-resolution native mass spectrometry and (glyco)peptide-centric proteomics. The proteoform profile of C9 was acquired by high-resolution native mass spectrometry, which revealed the co-occurrence of ~50 distinct MS signals...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28221106/pulmonary-nontuberculous-mycobacteria-associated-deaths-ontario-canada-2001-2013
#5
Theodore K Marras, Michael A Campitelli, Hong Lu, Hannah Chung, Sarah K Brode, Alex Marchand-Austin, Kevin L Winthrop, Andrea S Gershon, Jeffrey C Kwong, Frances B Jamieson
Survival implications of nontuberculous mycobacterial pulmonary disease (NTM-PD) and NTM pulmonary isolation without disease (NTM-PI) are unclear. To study deaths associated with NTM-PD and NTM-PI and differences in survival between them, we conducted a population-based cohort study of persons with microbiologically defined NTM-PD or NTM-PI diagnosed during 2001-2013 in Ontario, Canada. We used propensity score matching and Cox proportional hazards models to compare survival. Among 9,681 NTM-PD patients and 10,936 NTM-PI patients, 87% and 91%, respectively, were successfully matched with unexposed controls...
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28217953/b7-h4-deficiency-in-salivary-gland-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-impairs-the-regulatory-effect-on-t-cells
#6
Xiaomei Li, Daliang Yu, Ning Yu, Ximei Wang, Xiangpei Li, David C H Harris, Yiping Wang
AIM: Our previous study confirmed the defect of B7-H4 expression in peripheral blood and salivary glands of patients with primary Sjögren's syndrome (pSS). The aim of this study was to analyze the effect of the deficit expression of B7-H4 on CD4(+) T cells. METHODS: CD4(+) T cells were purified by magnetic-activated cell sorting MACS. The proliferation and cytokine production of CD4(+) T cells co-cultured with purified salivary gland epithelial cells (SGECs) from pSS or non-SS sicca syndrome were detected...
February 20, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28217403/hearing-loss-and-quality-of-life-qol-among-human-immunodeficiency-virus-hiv-infected-and-uninfected-adults
#7
N Duong, P Torre, G Springer, C Cox, M W Plankey
OBJECTIVE: Research has established that human immunodeficiency virus (HIV) causes hearing loss. Studies have yet to evaluate the impact on quality of life (QOL). This project evaluates the effect of hearing loss on QOL by HIV status. METHODS: The study participants were from the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV study (WIHS). A total of 248 men and 127 women participated. Pure-tone air conduction thresholds were collected for each ear at frequencies from 250 through 8000 Hz...
December 2016: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/28217398/comparison-of-intubation-success-and-glottic-visualization-using-king-vision-and-c-mac-videolaryngoscopes-in-patients-with-cervical-spine-injuries-with-cervical-immobilization-a-randomized-clinical-trial
#8
Dhanyasi Shravanalakshmi, Prasanna U Bidkar, K Narmadalakshmi, Suman Lata, Sandeep K Mishra, S Adinarayanan
BACKGROUND: Glottic visualization can be difficult with cervical immobilization in patients with cervical spine injury. Indirect laryngoscopes may provide better glottic visualization in these groups of patients. Hence, we compared King Vision videolaryngoscope, C-MAC videolaryngoscope for endotracheal intubation in patients with proven/suspected cervical spine injury. METHODS: After standard induction of anesthesia, 135 patients were randomized into three groups: group C (conventional C-MAC videolaryngoscope), group K (King Vision videolaryngoscope), and group D (D blade C-MAC videolaryngoscope)...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28175106/p491-comparison-of-the-durability-of-response-to-subcutaneous-anti-tnf-therapy-between-ulcerative-colitis-and-crohn-s-disease
#9
G Mellotte, C McShane, J O'Connell, S Mc Kiernan, F Mac Carthy, D Kevans
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28168139/video-laryngoscopy-vs-direct-laryngoscopy-in-teaching-neonatal-endotracheal-intubation-a-simulation-based-study
#10
Srikumar Nair, Eric J Thomas, Lakshmi Katakam
BACKGROUND: Neonatal endotracheal intubation is a life-saving procedural skill where best practices have been developed from expert opinion. Few empirical studies have examined how this skill should be taught. OBJECTIVE: To determine whether a video laryngoscope (VL) assisted intubation training curriculum compared to a traditional direct laryngoscope (DL) assisted curriculum improves neonatal intubation performance of novice intubators in a simulated setting. METHODS: A randomized trial of novice intubators was conducted at the University of Texas-Houston from 6/2013-8/2013...
January 6, 2017: Curēus
https://www.readbyqxmd.com/read/28165154/predictors-of-treatment-efficacy-and-alt-non-normalization-with-sofosbuvir-ribavirin-therapy-for-patients-with-hepatitis-c-virus-genotype-2
#11
Takao Watanabe, Yoshio Tokumoto, Kouji Joko, Kojiro Michitaka, Norio Horiike, Yoshinori Tanaka, Fujimasa Tada, Yoshiyasu Kisaka, Seiji Nakanishi, Takashi Nonaka, Kazuhiko Yamauchi, Masashi Hirooka, Masanori Abe, Yoichi Hiasa
AIM: The tolerability and efficacy of sofosbuvir and ribavirin in patients infected with hepatitis C virus (HCV) genotype 2 were investigated under actual clinical conditions. METHODS: A total of 208 patients with chronic HCV genotype 2 infection were treated with sofosbuvir 400 mg and ribavirin (weight-based dosing) for 12 weeks. Treatment discontinuation and sustained virological response 12 (SVR12) were evaluated. Moreover, factors associated with SVR12, hemoglobin decreasing to less than 10 g/dL during treatment, and alanine aminotransferase (ALT) non-normalization after treatment were evaluated...
February 6, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28160743/dioxolanea3-phosphatidylethanolamines-are-generated-by-human-platelets-and-stimulate-neutrophil-integrin-expression
#12
Maceler Aldrovandi, Christine Hinz, Sarah N Lauder, Helen Podmore, Martin Hornshaw, David A Slatter, Victoria J Tyrrell, Stephen R Clark, Lawrence J Marnett, Peter W Collins, Robert C Murphy, Valerie B O'Donnell
Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA3). Herein, we demonstrate that significant amounts of DXA3 are rapidly attached to phosphatidylethanolamine (PE) forming four esterified eicosanoids, 16:0p, 18:0p, 18:1p and 18:0a/DXA3-PEs that can activate neutrophil integrin expression. These lipids comprise the majority of DXA3 generated by platelets, are formed in ng amounts (24.3±6.1ng/2×10(8)) and remain membrane bound. Pharmacological studies revealed DXA3-PE formation involves cyclooxygenase-1 (COX), protease-activated receptors (PAR) 1 and 4, cytosolic phospholipase A2 (cPLA2), phospholipase C and intracellular calcium...
January 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28150579/clinical-significance-of-the-radiological-severity-score-in-mycobacterium-avium-complex-lung-disease-patients
#13
K Furuuchi, A Ito, T Hashimoto, S Kumagai, T Ishida
<h2>SETTING:</h2><p>Practical methods for assessing the radiographic findings of Mycobacterium avium complex lung disease (MAC-LD) have not been established.</p><h2>OBJECTIVE:</h2><p>To identify a correlation between the radiological score and semi-quantitative culture results of respiratory samples, and to assess the prognostic impact of this radiological score in MAC-LD patients.</p><h2>DESIGN:</h2><p>We retrospectively studied 218 MAC-LD patients...
January 26, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28149039/overcoming-a-difficult-nasogastric-tube-insertion-procedure-with-a-video-laryngoscope-c-mac-%C3%A2
#14
T Kumaravadivel Dharmalingam, Vivekananda Gunasekaran
No abstract text is available yet for this article.
December 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28139309/comparison-of-macintosh-and-intubrite-laryngoscopes-for-intubation-performed-by-novice-physicians-in-a-difficult-airway-scenario
#15
Lukasz Szarpak, Jacek Smereka, Jerzy R Ladny
INTRODUCTION: In the difficult airway, the intubation skills are critically important. In selected cases, particularly in airway edema, laryngeal or tongue edema, endotracheal intubation can turn out very difficult, and repeated attempts may even worsen the airway edema, causing trauma and bleeding, and finally leading to complete airway obstruction and inability to ventilate the patient. AIM OF THE STUDY: The aim of the study was to compare the efficacy of endotracheal intubation performed by novice physicians using a standard Macintosh laryngoscope and an Intubrite videolaryngoscope...
January 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28124478/defining-the-optimal-dose-of-rifapentine-for-pulmonary-tuberculosis-exposure-response-relations-from-two-phase-2-clinical-trials
#16
Radojka M Savic, Marc Weiner, William R Mac Kenzie, Melissa Engle, William C Whitworth, John L Johnson, Pheona Nsubuga, Payam Nahid, Nhung Viet Nguyen, Charles A Peloquin, Kelly E Dooley, Susan E Dorman
Rifapentine is a highly active antituberculosis antibiotic with treatment-shortening potential; however, exposure-response relations and the dose needed for maximal bactericidal activity have not been established. We used pharmacokinetic/pharmacodynamic data from 657 adults with pulmonary tuberculosis participating in treatment trials to compare rifapentine (n = 405) with rifampin (n = 252) as part of intensive-phase therapy. Population pharmacokinetic/pharmacodynamic analyses were performed with nonlinear mixed-effects modeling...
January 25, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28111740/anaesthetic-induced-cardioprotection-in-an-experimental-model-of-the-takotsubo-syndrome-isoflurane-vs-propofol
#17
J Oras, B Redfors, A Ali, J Lundgren, C Sihlbom, A Thorsell, H Seeman-Lodding, E Omerovic, S-E Ricksten
BACKGROUND: Takotsubo syndrome (TS) is an acute cardiac condition with a substantial mortality for which no specific treatment is available. We have previously shown that isoflurane attenuates the development of left ventricular (LV) dysfunction in an experimental TS-model. We compared the effects of equi-anaesthetic doses of isoflurane, propofol and ketamine+midazolam on haemodynamics, global and regional LV systolic function and the activation of intracellular metabolic pathways in experimental TS...
March 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28105639/persistent-variation-in-medicare-payment-authorization-for-home-hemodialysis-treatments
#18
Adam S Wilk, Richard A Hirth, Wei Zhang, John R C Wheeler, Marc N Turenne, Tammie A Nahra, Kathryn K Sleeman, Joseph M Messana
OBJECTIVE: To analyze variation in medical care use attributable to Medicare's decentralized claims adjudication process as exemplified in home hemodialysis (HHD) therapy. DATA SOURCES/STUDY SETTING: Secondary data analysis using 2009-2012 paid Medicare claims for HHD and in-center hemodialysis (IHD). STUDY DESIGN: We compared variation across Medicare administrative contractors (MACs) in predicted paid treatments per standardized patient-month for HHD and IHD patients...
January 19, 2017: Health Services Research
https://www.readbyqxmd.com/read/28105260/shear-wave-elastography-in-hepatitis-c-patients-before-and-after-antiviral-therapy
#19
Toshikuni Suda, Osamu Okawa, Rion Masaoka, Yoshinori Gyotoku, Naohiko Tokutomi, Yasumi Katayama, Masaya Tamano
AIM: To investigate shear wave (SW) propagation velocity in patients with untreated hepatitis C and patients with sustained virological response (SVR). METHODS: A total of 136 hepatitis C patients [85 patients who had not received antiviral therapy (naïve group) and 51 patients who had received antiviral therapy and subsequently achieved SVR of at least 24 wk (SVR group)] and 58 healthy volunteers and outpatients without liver disease (control group) underwent evaluation of liver stiffness by SW elastography (SWE)...
January 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28096584/randomized-controlled-study-comparing-the-hemodynamic-response-to-laryngoscopy-and-endotracheal-intubation-with-mccoy-macintosh-and-c-mac-laryngoscopes-in-adult-patients
#20
Faiza Sulaiman Buhari, Venkatesh Selvaraj
BACKGROUND AND AIMS: Earlier studies have shown that the type of laryngoscope blade influences the degree of hemodynamic response to endotracheal intubation. The aim of the study was to evaluate the hemodynamic response to oral endotracheal intubation with C-MAC laryngoscopy and McCoy laryngoscopy compared to that of Macintosh laryngoscopy in adult patients under general anesthesia. MATERIAL AND METHODS: This is a prospective randomized parallel group study. Ninety American Society of Anesthesiologists I patients were randomly allotted into three groups...
October 2016: Journal of Anaesthesiology, Clinical Pharmacology
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