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https://www.readbyqxmd.com/read/29768629/controversial-issues-in-the-management-of-hyperprolactinemia-and-prolactinomas-an-overview-by-the-neuroendocrinology-department-of-the-brazilian-society-of-endocrinology-and-metabolism
#1
Lucio Vilar, Julio Abucham, José Luciano Albuquerque, Luiz Antônio Araujo, Monalisa F Azevedo, Cesar Luiz Boguszewski, Luiz Augusto Casulari, Malebranche B C Cunha Neto, Mauro A Czepielewski, Felipe H G Duarte, Manuel Dos S Faria, Monica R Gadelha, Heraldo M Garmes, Andrea Glezer, Maria Helane Gurgel, Raquel S Jallad, Manoel Martins, Paulo A C Miranda, Renan M Montenegro, Nina R C Musolino, Luciana A Naves, Antônio Ribeiro-Oliveira Júnior, Cíntia M S Silva, Camila Viecceli, Marcello D Bronstein
Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare...
March 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29764749/prognosis-of-chronic-pulmonary-aspergillosis-in-patients-with-pulmonary-non-tuberculous-mycobacterial-disease
#2
Maiko Naito, Yu Kurahara, Shiomi Yoshida, Naoya Ikegami, Takehiko Kobayashi, Shojiro Minomo, Kazunobu Tachibana, Kazunari Tsuyuguchi, Seiji Hayashi, Katsuhiro Suzuki
BACKGROUND: Pulmonary non-tuberculous mycobacterial disease (PNTM) is a known risk factor for chronic pulmonary aspergillosis (CPA). However, few studies have focused on the prognosis of PNTM-associated CPA. In the present investigation, we aimed to elucidate the clinical course and prognostic factors of CPA in patients with PNTM. METHODS: We retrospectively investigated the medical records of 62 patients with CPA and a history of PNTM who were admitted to Kinki-chuo Chest Medical Center between 2010 and 2015...
May 11, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29738834/interaction-of-complement-system-and-microglia-activation-in-retina-and-optic-nerve-in-a-nmda-damage-model
#3
Sandra Kuehn, Sabrina Reinehr, Gesa Stute, Cara Rodust, Pia Grotegut, Alexander-Tobias Hensel, H Burkhard Dick, Stephanie C Joachim
It is known that intravitreally injected N-methyl-d-aspartate (NMDA) leads to fast retina and optic nerve degeneration and can directly activate microglia. Here, we analyzed the relevance for microglia related degenerating factors, the proteins of the complement system, at a late stage in the NMDA damage model. Therefore, different doses of NMDA (0 (PBS), 20, 40, 80 nmol) were intravitreally injected in rat eyes. Proliferative and activated microglia/macrophages (MG/Mϕ) were found in retina and optic nerve 2 weeks after NMDA injection...
May 5, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29730712/homing-genes-expression-in-fucosyltransferase-vi-treated-umbilical-cord-blood-cd133-cells-which-expanded-on-protein-coated-nanoscaffolds
#4
Amir Atashi, Maryam Islami, Yousef Mortazavi, Masoud Soleimani
Umbilical cord blood (UCB)-derived hematopoietic stem cells (HSCs) are considered because of their self-renewing, differentiating, proliferating, and readily available properties. Moreover, HSCs' homing to the hematopoietic microenvironment is an important step in their transplantation process. But low content of progenitor cells in one unit of UCB and defect in the bone marrow (BM) homing limit their applications. Hence, we decided to correct this deficiency with ex vivo incubation of CD133+ cells using fucosyltransferase VI and GDP-fucose...
May 5, 2018: Molecular Biotechnology
https://www.readbyqxmd.com/read/29730053/functional-vision-and-quality-of-life-in-children-with-microphthalmia-anophthalmia-coloboma-a-cross-sectional-study
#5
Annegret Dahlmann-Noor, Vijay Tailor, Yassir Abou-Rayyah, Gillian Adams, John Brookes, Sir Peng T Khaw, Catey Bunce, Maria Papadopoulos
PURPOSE: To determine the child's and parental perception of functional visual ability (FVA), vision-related and health-related quality of life (VR-QoL, HR-QoL) in children with microphthalmia/anophthalmia/coloboma (MAC). METHODS: Between June 25, 2014, and June 3, 2015, we carried out a cross-sectional observational study at Moorfields Eye Hospital, London, UK, enrolling 45 children 2-16 years of age with MAC attending our clinics, and their parents. To assess FVA, VR-QoL, and HR-QoL we asked participants to complete three validated tools, the Cardiff Visual Ability Questionnaire for Children (CVAQC), the Impact of Vision Impairment for Children (IVI-C) instrument, and the PedsQL V 4...
May 3, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29729916/short-communication-high-incubation-temperature-in-bovine-mammary-epithelial-cells-reduced-the-activity-of-the-mtor-signaling-pathway
#6
J D Kaufman, K R Kassube, R A Almeida, A G Ríus
Hyperthermia alters utilization of AA in protein synthesis and cell-signaling activity in bovine mammary cells. Essential AA and insulin regulate translation of proteins by controlling the activity of mammalian target of rapamycin (mTOR) signaling pathway. The objectives of this study were to evaluate (1) the effects of incubation temperature on the mTOR signaling pathway and transcription of AA transporters in a bovine mammary alveolar cell line (MAC-T) and (2) the combined effects of incubation temperature and insulin on the mTOR signaling pathway in this cell line...
May 2, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29722808/knoto-id-a-tool-to-study-the-entanglement-of-open-protein-chains-using-the-concept-of-knotoids
#7
Julien Dorier, Dimos Goundaroulis, Fabrizio Benedetti, Andrzej Stasiak
Summary: The backbone of most proteins forms an open curve. To study their entanglement, a common strategy consists in searching for the presence of knots in their backbones using topological invariants. However, this approach requires to close the curve into a loop, which alters the geometry of curve. Knoto-ID allows evaluating the entanglement of open curves without the need to close them, using the recent concept of knotoids which is a generalization of the classical knot theory to open curves...
May 2, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29716504/combined-use-of-c-mac%C3%A2-videolaryngoscope-and-nasal-videobronchoscope-for-critical-airway-rescue-and-intubation
#8
J R Cormack, M L Ho
No abstract text is available yet for this article.
May 2018: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29709404/microbiology-of-french-military-casualties-repatriated-from-overseas-for-an-open-traumatic-injury
#9
S Larréché, A Bousquet, C Soler, C Mac Nab, D de Briel, D Delaune, C Bigaillon, P Pasquier, C Dubost, T Demoures, B Malgras, S Ausset, S de Rudnicki, T Leclerc, B de Loynes, S Bonnet, N Mocellin, C Ficko, R Haus, O Hersan, S Rigal, A Mérens
BACKGROUND: This study aimed to describe the microbiological epidemiology of repatriated French soldiers with an open traumatic injury, and to measure the proportion of multidrug-resistant bacteria (MDRB). METHODS: Retrospective study including all French soldiers repatriated in 2011 and 2012 in Parisian military hospitals for open traumatic injury. Results of clinical samples and MDRB screening were collected. The antibiotic susceptibility was assessed using the agar disk diffusion method...
April 27, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29704938/evaluation-of-the-humoral-immune-response-to-a-multicomponent-recombinant-vaccine-against-s-aureus-in-healthy-pregnant-heifers
#10
N Pujato, C M Camussone, M S Renna, M S Perrig, B Morein, L F Calvinho, I S Marcipar
Staphylococcus aureus is a worldwide pathogen that causes mastitis in dairy herds. Shortcomings in control programs have encouraged the development of vaccines against this pathogen. This study evaluated the vaccine candidate VacR, which included recombinant S. aureus protein clumping factor A (rClf), fibronectin binding protein A (rFnBP) and hemolysin beta (rBt), formulated with a novel immune-stimulating complex. Comparisons were made between healthy pregnant heifers that received either VacR (n=8; VacR group) or phosphate buffered saline (PBS) plus adjuvant (control group) SC in the supramammary lymph node area on days 45 and 15 before the expected calving date...
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29695555/laminarin-promotes-immune-responses-and-reduces-lactate-dehydrogenase-but-increases-glutamic-pyruvic-transaminase-in-normal-mice-in-vivo
#11
Yung-Luen Shih, Shu-Ching Hsueh, Yung-Liang Chen, Jiann-Shang Chou, Hsueh-Yu Chung, Ko-Lin Liu, Herng-Woei Jair, Ying-Ying Chuang, Hsu-Feng Lu, Jia-You Liu, Jing-Gung Chung
BACKGROUND/AIM: Laminarin, a typical component of fungal cell walls, has been shown to induce immune responses in both adult and larval locusts. We investigated the effects of laminarin on immune response and glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) levels in normal mice. MATERIALS AND METHODS: Thirty-six normal BALB/c mice were randomly divided into four groups and treatments were provided by gavage...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29686297/microbiota-accessible-carbohydrates-suppress-clostridium-difficile-infection-in-a-murine-model
#12
Andrew J Hryckowian, William Van Treuren, Samuel A Smits, Nicole M Davis, Jackson O Gardner, Donna M Bouley, Justin L Sonnenburg
Clostridium difficile is an opportunistic diarrhoeal pathogen, and C. difficile infection (CDI) represents a major health care concern, causing an estimated 15,000 deaths per year in the United States alone 1 . Several enteric pathogens, including C. difficile, leverage inflammation and the accompanying microbial dysbiosis to thrive in the distal gut 2 . Although diet is among the most powerful available tools for affecting the health of humans and their relationship with their microbiota, investigation into the effects of diet on CDI has been limited...
April 23, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29660807/a-randomised-clinical-trial-comparing-the-sniffing-and-neutral-position-using-channelled-kingvision-%C3%A2-and-non-channelled-c-mac-%C3%A2-videolaryngoscopes
#13
C Mendonca, N Ungureanu, A Nowicka, P Kumar
Head and neck position is one of the factors which can be associated with difficult videolaryngoscopy and tracheal intubation. This prospective randomised clinical trial compared 'sniffing' and neutral positions using a channelled (KingVision® ) and a non-channelled (C-MAC® D-blade) videolaryngoscope in 200 adult patients randomly allocated into four groups (KingVision 'sniffing', KingVision neutral, C-MAC 'sniffing' and C-MAC neutral). The primary outcome was the ease of tracheal intubation using the modified intubation difficulty scale (mIDS) score...
April 16, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29629959/baseline-cerebral-metabolic-rate-is-a-critical-determinant-of-the-cerebral-vasodilating-potency-of-volatile-anesthetic-agents
#14
John C Drummond
Halothane is commonly viewed as a more potent cerebral vasodilator than isoflurane. It was speculated that the lesser vasodilation caused by isoflurane might be the result of the greater reduction in cerebral metabolic rate (CMR) that it causes, and that the relative vasodilating potencies of halothane and isoflurane would be similar if the two agents were administered in a situation that precluded volatile-agent-induced depression of CMR. To test this hypothesis, cerebral blood flow (CBF) and the cerebral metabolic rate for oxygen (CMRO2) were measured in two groups of rabbits before and after the administration of 0...
April 9, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29628581/ease-of-intubation-with-c-mac-videolaryngoscope-use-of-60%C3%A2-angled-styletted-endotracheal-tube-versus-intubation-over-bougie
#15
Pulak Tosh, Sunil Rajan, Lakshmi Kumar
Background: Although videolaryngoscopes improve glottic visualization, their actual usefulness in intubation is not yet established. Aims: The primary objective was to compare the ease of oral intubation with the use of 60° angled styletted endotracheal tube versus that performed over bougie inserted under videolaryngoscopic guidance. The secondary objectives were assessment of incidence of airway loss, hemodynamic changes, and time and number of attempts at intubation...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628570/effect-of-c-mac-video-laryngoscope-aided-intubations-using-d-blade-on-incidence-and-severity-of-postoperative-sore-throat
#16
Pulak Tosh, Dilesh Kadapamannil, Sunil Rajan, Naina Narayani, Lakshmi Kumar
Background: Video laryngoscope-aided intubations require less force to align oral, pharyngeal, and laryngeal planes to visualize the glottis opening during intubation. Aim: The primary objective of the study was to assess the incidence and severity of postoperative sore throat (POST) in patients who were intubated with C-MAC video laryngoscope using D-blade versus traditional Macintosh laryngoscope. Settings and Design: This prospective, randomized, open label study was conducted in a tertiary care institution...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29626643/patterns-of-repeated-anal-cytology-results-among-hiv-positive-and-hiv-negative-men-who-have-sex-with-men
#17
Hilary A Robbins, Dorothy J Wiley, Ken Ho, Michael Plankey, Susheel Reddy, Nancy Joste, Teresa M Darragh, Elizabeth C Breen, Stephen Young, Gypsyamber D'Souza
BACKGROUND: Men who have sex with men (MSM) are at increased risk for anal cancer. In cervical cancer screening, patterns of repeated cytology results are used to identify low- and high-risk women, but little is known about these patterns for anal cytology among MSM. METHODS: We analyzed Multicenter AIDS Cohort Study (MACS) data for MSM who were offered anal cytology testing annually (HIV-positive) or every 2 years (HIV-negative) for 4 years. RESULTS: Following an initial negative (normal) cytology, the frequency of a second negative cytology was lower among HIV-positive MSM with CD4≥500 (74%) or CD4<500 (68%) than HIV-negative MSM (83%) (p<0...
April 4, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29626296/real-world-efficacy-and-safety-of-ledipasvir-and-sofosbuvir-in-patients-with-hepatitis-c-virus-genotype-1-infection-a-nationwide-multicenter-study-by-the-japanese-red-cross-liver-study-group
#18
Keiji Tsuji, Masayuki Kurosaki, Jun Itakura, Nami Mori, Shintaro Takaki, Chitomi Hasebe, Takehiro Akahane, Kouji Joko, Hitoshi Yagisawa, Jirou Takezawa, Ryou Nakata, Atsunori Kusakabe, Yuji Kojima, Hiroyuki Kimura, Takashi Tamada, Haruhiko Kobashi, Akeri Mitsuda, Masahiko Kondou, Chikara Ogawa, Yasushi Uchida, Tetsuro Sohda, Ryouichi Narita, Namiki Izumi
BACKGROUND: We aimed to describe the real-world efficacy and safety of combination therapy with ledipasvir and sofosbuvir (LDV/SOF) for chronic hepatitis C virus (HCV) genotype 1 (GT1) infection. METHODS: This retrospective analysis of a prospective, nationwide, multicenter registry included GT1-infected patients treated with LDV/SOF for 12 weeks. We assessed the rate of sustained virological response at 12 weeks post-treatment (SVR12), incidence of adverse events, and serum markers of hepatocellular carcinoma (HCC)...
April 6, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29620480/improved-health-and-insurance-status-among-cigarette-smokers-after-medicaid-expansion-2011-2016
#19
Clare C Brown, J Mick Tilford, T Mac Bird
OBJECTIVES: The high concentration of smokers among subgroups targeted by the Affordable Care Act and the historically worse health and lower access to health care among smokers warrants an evaluation of how Medicaid expansion affects smokers. We evaluated the impact of Medicaid expansion on smoking behavior, access to health care, and health of low-income adults, and we compared outcomes of all low-income people with outcomes of low-income current smokers by states' Medicaid expansion status...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29611788/c-mac-%C3%A2-videolaryngoscopy-the-anaesthetic-assistant-s-view
#20
Lydia Jones, Kathleen Mulcahy, Jeremy Fox, Tim M Cook, Fiona E Kelly
Although videolaryngoscopy plays a major role in the 2015 Difficult Airway Society guidelines, the impact on anaesthetic assistant working practices and training has not previously been reported. We surveyed anaesthetic assistants in our hospital to document their experience with using the C-MAC© videolaryngoscope (48 practitioners, 100% response rate). Improvements in the following were reported: patient safety 100%; ability to see whether laryngoscopy is difficult 98%; ability to anticipate the 'next step' 98%; team-working and human factors 96%; ability to call a senior anaesthetist more quickly 94%; assessment or adjustment of cricoid force application 92%, understanding of laryngeal anatomy 92%; training in intubation 98%; training in cricoid force application 87%...
April 2018: Journal of Perioperative Practice
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