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https://www.readbyqxmd.com/read/29330118/using-the-ribodeblur-pipeline-to-recover-a-sites-from-yeast-ribosome-profiling-data
#1
Hao Wang, Carl Kingsford, C Joel McManus
Ribosome profiling has emerged as a powerful technique to study mRNA translation. Ribosome profiling has the potential to determine the relative quantities and locations of ribosomes on mRNA genome wide. Taking full advantage of this approach requires accurate measurement of ribosome locations. However, experimental inconsistencies often obscure the positional information encoded in ribosome profiling data. Here, we describe the Ribodeblur pipeline, a computational analysis tool that uses a maximum likelihood framework to infer ribosome positions from heterogeneous datasets...
January 9, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29318378/mac-2-binding-protein-glycan-isomer-m2bpgi-is-a-new-serum-biomarker-for-assessing-liver-fibrosis-more-than-a-biomarker-of-liver-fibrosis
#2
REVIEW
Ken Shirabe, Yuki Bekki, Dolgormaa Gantumur, Kenichiro Araki, Norihiro Ishii, Atsushi Kuno, Hisashi Narimatsu, Masashi Mizokami
Assessing liver fibrosis is important for predicting the efficacy of antiviral therapy and patient prognosis. Liver biopsy is the gold standard for diagnosing liver fibrosis, despite its invasiveness and problematic diagnostic accuracy. Although noninvasive techniques to assess liver fibrosis are becoming important, reliable serum surrogate markers are not available. A glycoproteomics study aimed at identifying such markers discovered Mac 2-Binding Protein Gylcan Isomer (M2BPGi), which is a reliable marker for assessing liver fibrosis in patients with viral hepatitis and other fibrotic liver diseases such as primary biliary cholangitis, biliary atresia, autoimmune hepatitis, and nonalcoholic fatty liver disease...
January 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29316028/wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-predicts-the-development-of-hepatocellular-carcinoma-in-patients-with-nonalcoholic-fatty-liver-disease
#3
Miwa Kawanaka, Yasuyuki Tomiyama, Hideyuki Hyogo, Masahiko Koda, Toshihide Shima, Hiroshi Tobita, Akira Hiramatsu, Ken Nishino, Toshiaki Okamoto, Shuichi Sato, Yuichi Hara, Sohji Nishina, Hirofumi Kawamoto, Kazuaki Chayama, Takeshi Okanoue, Keisuke Hino
AIM: As it is not practical to survey hepatocellular carcinoma (HCC) in all patients with nonalcoholic fatty liver disease (NAFLD), there is a need to identify NAFLD patients who are at high risk for HCC. Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) has been demonstrated to be a surrogate marker for predicting HCC as well as a liver fibrosis marker in patients with chronic hepatitis B and C. The aim of this study was to investigate whether WFA+ -M2BP predicts HCC development in NAFLD patients...
January 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29315473/a-before-and-after-observational-study-of-a-protocol-for-use-of-the-c-mac-videolaryngoscope-with-a-frova-introducer-in-pre-hospital-rapid-sequence-intubation
#4
S Ångerman, H Kirves, J Nurmi
Results using videolaryngoscopy in pre-hospital rapid sequence intubation are mixed. A bougie is not commonly used with videolaryngoscopy. We hypothesised that using videolaryngoscopy and a bougie as core elements of a standardised protocol that includes a drugs and a laryngoscopy algorithm would result in a high first-pass tracheal intubation success rate. We employed videolaryngoscopy (C-MAC) combined with a bougie (Frova intubating introducer) in an anaesthetist-staffed helicopter emergency medical service...
January 8, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29310350/relationship-between-skeletal-muscle-mass-and-liver-fibrosis-markers-for-patients-with-hepatitis-c-virus-related-liver-disease
#5
Ryo Takata, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yuho Miyamoto, Noriko Ishii, Yukihisa Yuri, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Kazunori Yoh, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
We aimed to elucidate the relationship between serum liver fibrosis markers (Mac-2 binding protein glycosylation isomer (M2BPGi), FIB-4 index, aspartate aminotransferase to platelet ratio index and hyaluronic acid), and skeletal muscle mass and to investigate factors linked to skeletal muscle mass loss (SMML) in patients with chronic hepatitis C (CHC, n = 277, median age = 64 years). We defined patients with psoas muscle index [PMI, sum of bilateral psoas muscle mass calculated by manual trace method at the lumber 3 level on the computed tomography images divided by height squared (cm/m)] less than 6...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29304735/effect-of-single-dose-dexmedetomidine-on-postoperative-recovery-after-ambulatory-ureteroscopy-and-ureteric-stenting-a-double-blind-randomized-controlled-study
#6
I I Shariffuddin, W H Teoh, S Wahab, C Y Wang
BACKGROUND: Ambulatory surgery has recently gain popularity, as it is a good method of optimizinghospital resources utilization. To support ambulatory surgery, anaesthetic goals nowrevolve around patients' early recovery with minimal pain and nausea, expedientdischarge home and prompt resumption of activities of daily living. In this study, weevaluated the effect of a single pre-induction dose of dexmedetomidine on anaestheticrequirements, postoperative pain and clinical recovery after ambulatory ureteroscopy andureteric stenting under general anaesthesia...
January 5, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29300845/chronqc-a-quality-control-monitoring-system-for-clinical-next-generation-sequencing
#7
Nilesh R Tawari, Justine Jia Wen Seow, Perumal Dharuman, Jack L Ow, Shimin Ang, Arun George Devasia, Pauline C Ng
Summary: ChronQC is a quality control (QC) tracking system for clinical implementation of next-generation sequencing (NGS). ChronQC generates time series plots for various QC metrics to allow comparison of current runs to historical runs. ChronQC has multiple features for tracking QC data including Westgard rules for clinical validity, laboratory-defined thresholds, and historical observations within a specified time period. Users can record their notes and corrective actions directly onto the plots for long-term recordkeeping...
December 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29285816/arterialized-collateral-capillaries-progress-from-non-reactive-to-capable-of-increasing-perfusion-in-an-ischemic-tree
#8
Kenneth H Gouin, Sara K Hellstrom, Lindsay E Clegg, Joshua Cutts, Feilim Mac Gabhann, Trevor R Cardinal
OBJECTIVE: Collateral capillary arteriogenenesis (CCA), outward remodeling of capillaries that anastomose two arteriolar trees with different parent feed arteries, may represent a therapeutic target for patients who lack collaterals. Arterialized collateral capillaries (ACCs) can reperfuse an ischemic tree, but their functional capacity is unknown. Therefore, we determined if ACCs mature into resistance vessels that regulate blood flow following arterial occlusion. METHODS: We ligated the lateral spinotrapezius feed artery in Balb/C mice, which induces CCA...
December 28, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29282280/ligand-specific-binding-forces-of-lfa-1-and-mac-1-in-neutrophil-adhesion-and-crawling
#9
Ning Li, Hao Yang, Manliu Wang, Shouqin Lü, Yan Zhang, Mian Long
Lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1), and their counter-receptors such as intercellular cell adhesion molecule (ICAM)-1 and ICAM-2, junctional adhesion molecule (JAM)-A, JAM-C and receptor for advanced glycation end products (RAGE) are crucial to promote polymorphonuclear leukocyte (neutrophil, PMN) recruitment. The underlying mechanisms of ligand-specific bindings in this cascade remain incompletely known. We compared the dynamic force spectrum for various LFA-1/Mac-1-ligand bonds using single molecule atomic force microscopy (AFM) and tested their functions to mediate PMN recruitment under in vitro shear flow...
December 27, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29249315/the-immunomodulatory-function-of-equine-mscs-is-enhanced-by-priming-through-an-inflammatory-microenvironment-or-tlr3-ligand
#10
Jennifer M Cassano, Lauren V Schnabel, Margaret B Goodale, Lisa A Fortier
Mesenchymal stem cells (MSCs) have the therapeutic potential to treat a variety of inflammatory and degenerative disease processes, however the effects of the tissue environment on MSCs have been overlooked. Our hypothesis was that the immunomodulatory function of MSCs would be impaired by TLR4 stimulation or exposure to inflammatory macrophages, whereas their immunosuppressive properties would be enhanced by TLR3 stimulation. MSCs were exposed to polyinosinic:polycytidylic acid (poly I:C) to stimulate TLR3 receptors or lipopolysaccharide (LPS) to stimulate TLR4 receptors...
January 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29248387/the-prevalence-of-food-sensitization-appears-not-to-have-changed-between-2-melbourne-cohorts-of-high-risk-infants-recruited-15-years-apart
#11
Rachel L Peters, Jennifer J Koplin, Katrina J Allen, Adrian J Lowe, Caroline J Lodge, Mimi L K Tang, Melissa Wake, Anne-Louise Ponsonby, Bircan Erbas, Michael J Abramson, David Hill, Lyle C Gurrin, Shyamali C Dharmage
BACKGROUND: Although food allergy has probably risen over recent decades, recent reports suggest that the prevalence of food sensitization in the general population has not changed. However, this has not been analyzed in infants at high risk of food allergy. OBJECTIVE: The objective of this study was to compare the prevalence of food sensitization in high-risk infants from 2 cohorts recruited 15 years apart in the same region. METHODS: This study includes 620 high-risk infants with a family history of allergy (Melbourne Atopy Cohort Study [MACS]) born 1990-1994, and a subgroup of high-risk infants from the population-based HealthNuts study (n = 3,661/5,276), born 2006-2010...
December 13, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29239965/videolaryngoscopy-for-physician-based-prehospital-emergency-intubation-a-prospective-randomized-multicenter-comparison-of-different-blade-types-using-a-p-advance-c-mac-system-and-kingvision
#12
Erol Cavus, Sebastian Janssen, Florian Reifferscheid, Amke Caliebe, Andreas Callies, Martin von der Heyden, Peer G Knacke, Volker Doerges
BACKGROUND: Videolaryngoscopy is a valuable technique for endotracheal intubation. When used in the perioperative period, different videolaryngoscopes vary both in terms of technical use and intubation success rates. However, in the prehospital environment, the relative performance of different videolaryngoscopic systems is less well studied. METHODS: We conducted this prospective, randomized, multicenter study at 4 German prehospital emergency medicine centers...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29233037/serum-wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-can-reflect-systemic-lupus-erythematosus-activity
#13
S S Ahn, Y Park, D D Lee, A L M Bothwell, S M Jung, J J Song, Y-B Park, S-W Lee
Serum Mac-2-binding protein (M2BP) is elevated in various chronic inflammatory diseases, and evidence suggests that glycosylation of M2BP induces discrete biological effects. However, the role of serum M2BP in systemic lupus erythematosus (SLE) is still unclear. Recently, a Wisteria floribunda agglutinin-positive-M2BP (WFA+-M2BP) immunoassay has shown promise in detecting highly glycosylated M2BP. In this study, by using WFA+-M2BP immunoassay, we measured serum M2BP in 203 SLE patients and evaluated its clinical significance...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29227421/an-assessment-of-information-exchange-practices-challenges-and-opportunities-to-support-us-disease-surveillance-in-3-states
#14
Macarena C Garcia, Nedra Y Garrett, Vivian Singletary, Sheereen Brown, Tamara Hennessy-Burt, Gillian Haney, Kimberly Link, Jennifer Tripp, William R Mac Kenzie, Paula Yoon
BACKGROUND: State and local public health agencies collect and use surveillance data to identify outbreaks, track cases, investigate causes, and implement measures to protect the public-s health through various surveillance systems and data exchange practices. PURPOSE: The purpose of this assessment was to better understand current practices at state and local public health agencies for collecting, managing, processing, reporting, and exchanging notifiable disease surveillance information...
December 7, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29220797/primaquine-hybrids-as-promising-antimycobacterial-and-antimalarial-agents
#15
Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Four series of primaquine (PQ) derivatives were screened for antitubercular and antiplasmodial activity: amides 1a-k, ureas 2a-s, semicarbazides 3a-c and bis-ureas 4a-u. Antimycobacterial activity of PQ derivatives against Mycobacterium tuberculosis (MTB), M. avium complex (MAC) and M. avium subsp. paratuberculosis (MAP) were evaluated in vitro and compared with PQ and the standard antitubercular drugs. In general, the PQ derivatives showed higher potency than the parent compound. Most of the compounds of series 1 and 2 showed high activity against MAP, comparable or even higher than the relevant drug ciprofloxacin, and weak or no activity against MTB and MAC...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29211032/bioavailability-of-bergamot-citrus-bergamia-flavanones-and-biological-activity-of-their-circulating-metabolites-in-human-pro-angiogenic-cells
#16
Valentina Spigoni, Pedro Mena, Federica Fantuzzi, Michele Tassotti, Furio Brighenti, Riccardo C Bonadonna, Daniele Del Rio, Alessandra Dei Cas
Myeloid angiogenic cells (MACs) play a key role in endothelial repairing processes and functionality but their activity may be impaired by the lipotoxic effects of some molecules like stearic acid (SA). Among the dietary components potentially able to modulate endothelial function in vivo, (poly)phenolic compounds represent serious candidates. Here, we apply a comprehensive multidisciplinary approach to shed light on the prospects of Bergamot (Citrus bergamia), a citrus fruit rich in flavanones and other phenolic compounds, in the framework of lipotoxicity-induced MACs impairment...
December 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29203543/a-novel-mechanism-behind-the-immunopathogenesis-of-vulvovaginal-candidiasis-neutrophil-anergy
#17
Junko Yano, Brian M Peters, Mairi C Noverr, Paul L Fidel
For over three decades, investigators have studied the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (RVVC) through clinical studies and animal models. While there was considerable consensus that susceptibility was not associated with any apparent deficiencies in adaptive immunity, protective immune mechanisms and the role of innate immunity remained elusive. It was not until an innovative live challenge design was conducted in women that a fuller understanding of the natural history of infection/disease was achieved...
December 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29202702/c-reactive-protein-crp-but-not-the-related-pentraxins-serum-amyloid-p-and-ptx3-inhibits-the-proliferation-and-induces-apoptosis-of-the-leukemia-cell-line-mono-mac-6
#18
Wensheng Chen, Darrell Pilling, Richard H Gomer
BACKGROUND: Pentraxins are a family of highly conserved secreted proteins that regulate the innate immune system, including monocytes and macrophages. C-reactive protein (CRP) is a plasma protein whose levels can rise to 1000 μg/ml from the normal <3 μg/ ml during inflammation. RESULTS: We find that CRP inhibits proliferation of the human myeloid leukemia cell line Mono Mac 6 with an IC50 of 75 μg/ ml by inducing apoptosis of these cells. The related proteins serum amyloid P (SAP) and pentraxin 3 (PTX3) do not inhibit Mono Mac 6 proliferation...
December 4, 2017: BMC Immunology
https://www.readbyqxmd.com/read/29193887/systems-pharmacology-of-vegf165b-in-peripheral-artery-disease
#19
Lindsay E Clegg, Vijay C Ganta, Brian H Annex, Feilim Mac Gabhann
We built a whole-body computational model to study the role of the poorly understood vascular endothelial growth factor (VEGF)165b splice isoform in peripheral artery disease (PAD). This model was built and validated using published and new experimental data from cells, mice, and humans, and explicitly accounts for known properties of VEGF165b : lack of extracellular matrix (ECM)-binding and weak phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR2) in vitro. The resulting model captures all known information about VEGF165b distribution and signaling in human PAD, and provides novel, nonintuitive insight into VEGF165b mechanism of action in vivo...
November 28, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29193633/evidence-based-dentistry-can-effectively-be-taught-to-dental-care-professional-students-a-mixed-methods-study
#20
A F Kahatab, Y B Ho, D O'Reilly, C Tan, J McTernan, T Ahmed, A O'Halloran, D Sagheri, A Abdollahi, C Mac Giolla Phadraig
BACKGROUND: Little research exists in the teaching of evidence-based dentistry (EBD) to students in the fields of dental hygiene, dental nursing and orthodontic therapy. This study aims to analyse the effect of a 1-day EBD programme on knowledge and confidence whilst also gaining insight into students' experience of the intervention. METHOD: A mixed methods study was utilised with explanatory sequential design. The population consisted of dental hygiene (DH), dental nursing (DN) and orthodontic therapy (OT) students (N = 44)...
November 28, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
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