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Wei-Wei Yang, Lei Li, Jing-Sheng Zhao, Xiao-Xiong Liu, Jian-Bo Deng, Xianru Hu
By doing calculations based on density functional theory (DFT), we predict that the two-dimensional anti-ferromagnetic (AFM) NiOsCl$_6$ as a Chern insulator can realize the quantum anomalous Hall (QAH) effect. We investigate the magnetocrystalline anisotropy (MAC) energies in different magnetic configurations and the N\'{e}el AFM configuration is proved to be ground state. When considering spin-orbit coupling (SOC), this layered material with spins perpendicular to the plane shows properties as a Chern insulator characterized by an inversion band structure and a nonzero Chern number...
March 19, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Junichi Tokuda, Laurent Chauvin, Brian Ninni, Takahisa Kato, Franklin King, Kemal Tuncali, Nobuhiko Hata
Patient-mounted needle guide devices for
 percutaneous ablations are vulnerable to patient motion. The objective of this study is to develop and evaluate a software system for MRI-compatible patient-mounted needle guide device that can adaptively compensate for the displacement of the device due to the patient motion using a novel image-based automatic device-to-image registration.
 Materials and Methods. We developed a software system for an MRI-compatible patient-mounted needle guide device for percutaneous ablations...
March 16, 2018: Physics in Medicine and Biology
Denise C Hsu, Kimberly F Breglio, Luxin Pei, Chun-Shu Wong, Bruno B Andrade, Virginia Sheikh, Margery Smelkinson, Constantinos Petrovas, Adam Rupert, Leonardo Gil-Santana, Adrian Zelazny, Steven M Holland, Kenneth Olivier, Daniel Barber, Irini Sereti
Background: Immune reconstitution inflammatory syndrome (IRIS) is an aberrant inflammatory response in individuals with advanced human immunodeficiency virus (HIV) infection, after antiretroviral therapy (ART) initiation. The pathogenesis of Mycobacterium avium complex (MAC)-associated IRIS has not been fully elucidated. Methods: We investigated monocyte and CD4+ T-cell responses in vitro, tumor necrosis factor (TNF) expression in tissues, and plasma cytokines and inflammatory markers, in 13 HIV-infected patients with MAC-IRIS and 14 HIV-uninfected patients with pulmonary MAC infection...
March 10, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Vojtech Franc, Jing Zhu, Albert J R Heck
The human complement hetero-trimeric C8αβγ (C8) protein assembly (~ 150 kDa) is an important component of the membrane attack complex (MAC). C8 initiates membrane penetration and coordinates MAC pore formation. Here, we charted in detail the structural micro-heterogeneity within C8, purified from human plasma, combining high-resolution native mass spectrometry and (glyco)peptide-centric proteomics. The intact C8 proteoform profile revealed at least ~ 20 co-occurring MS signals. Additionally, we employed ion exchange chromatography to separate purified C8 into four distinct fractions...
March 12, 2018: Journal of the American Society for Mass Spectrometry
Zheng Wei, Wei Zhang, Huan Fang, Yanda Li, Xiaowo Wang
Summary: ATAC-seq is rapidly emerging as one of the major experimental approaches to probe chromatin accessibility genome-wide. Here, we present "esATAC", a highly integrated easy-to-use R/Bioconductor package, for systematic ATAC-seq data analysis. It covers essential steps for full analyzing procedure, including raw data processing, quality control and downstream statistical analysis such as peak calling, enrichment analysis and transcription factor footprinting. esATAC supports one command line execution for preset pipelines, and provides flexible interfaces for building customized pipelines...
March 7, 2018: Bioinformatics
Nathalia Regina F Leal, Mariana Vieira Vigliano, Fabiana A Pinto, Thayane V de Sousa, Leosvaldo S M Velozo, Kátia C C Sabino, Maria da Graça Justo, Marsen Garcia Pinto Coelho
OBJECTIVES: To evaluate the anti-inflammatory potential of Pterodon polygalaeflorus hexane extract (HE) and its fractions on macrophage migration in vitro and in vivo. METHODS: Hexane extract from P. polygalaeflorus fruits was fractionated and yielded four fractions. RAW 264.7 cells were treated with samples to evaluate cell viability (MTT assay), cell migration (wound healing and transwell assays), CD14 expression (flow cytometry), iNOS and cytokine mRNA expression (RT-qPCR), NO (Griess reaction) and cytokine (ELISA) production...
March 7, 2018: Journal of Pharmacy and Pharmacology
P W Crous, M J Wingfield, T I Burgess, A J Carnegie, G E St J Hardy, D Smith, B A Summerell, J F Cano-Lira, J Guarro, J Houbraken, L Lombard, M P Martín, M Sandoval-Denis, A V Alexandrova, C W Barnes, I G Baseia, J D P Bezerra, V Guarnaccia, T W May, M Hernández-Restrepo, A M Stchigel, A N Miller, M E Ordoñez, V P Abreu, T Accioly, C Agnello, A Agustin Colmán, C C Albuquerque, D S Alfredo, P Alvarado, G R Araújo-Magalhães, S Arauzo, T Atkinson, A Barili, R W Barreto, J L Bezerra, T S Cabral, F Camello Rodríguez, R H S F Cruz, P P Daniëls, B D B da Silva, D A C de Almeida, A A de Carvalho Júnior, C A Decock, L Delgat, S Denman, R A Dimitrov, J Edwards, A G Fedosova, R J Ferreira, A L Firmino, J A Flores, D García, J Gené, A Giraldo, J S Góis, A A M Gomes, C M Gonçalves, D E Gouliamova, M Groenewald, B V Guéorguiev, M Guevara-Suarez, L F P Gusmão, K Hosaka, V Hubka, S M Huhndorf, M Jadan, Ž Jurjević, B Kraak, V Kučera, T K A Kumar, I Kušan, S R Lacerda, S Lamlertthon, W S Lisboa, M Loizides, J J Luangsa-Ard, P Lysková, W P Mac Cormack, D M Macedo, A R Machado, E F Malysheva, P Marinho, N Matočec, M Meijer, A Mešić, S Mongkolsamrit, K A Moreira, O V Morozova, K U Nair, N Nakamura, W Noisripoom, I Olariaga, R J V Oliveira, L M Paiva, P Pawar, O L Pereira, S W Peterson, M Prieto, E Rodríguez-Andrade, C Rojo De Blas, M Roy, E S Santos, R Sharma, G A Silva, C M Souza-Motta, Y Takeuchi-Kaneko, C Tanaka, A Thakur, M Th Smith, Z Tkalčec, N Valenzuela-Lopez, P van der Kleij, A Verbeken, M G Viana, X W Wang, J Z Groenewald
Novel species of fungi described in this study include those from various countries as follows: Antarctica : Cadophora antarctica from soil. Australia : Alfaria dandenongensis on Cyperaceae , Amphosoma persooniae on Persoonia sp., Anungitea nullicana on Eucalyptus sp . , Bagadiella eucalypti on Eucalyptus globulus , Castanediella eucalyptigena on Eucalyptus sp., Cercospora dianellicola on Dianella sp., Cladoriella kinglakensis on Eucalyptus regnans , Cladoriella xanthorrhoeae (incl. Cladoriellaceae fam. nov...
December 2017: Persoonia
Daniel C Sacchetti, Shawna M Cutting, Ryan A McTaggart, Andrew D Chang, Morgan Hemendinger, Brian Mac Grory, Matthew S Siket, Tina Burton, Bradford Thompson, Sara K Rostanski, Shyam Prabhakaran, Joshua Z Willey, Randolph S Marshall, Mitchell Sv Elkind, Pooja Khatri, Karen L Furie, Mahesh V Jayaraman, Shadi Yaghi
Background Large vessel disease stroke subtype carries the highest risk of early recurrent stroke. In this study we aim to look at the association between impaired perfusion and early stroke recurrence in patients with intracranial atherosclerotic disease or total cervical carotid occlusion. Methods This is a retrospective study from a comprehensive stroke center where we included consecutive patients 18 years or older with intracranial atherosclerotic disease or total cervical carotid occlusion admitted with a diagnosis of ischemic stroke within 24 h from symptom onset with National Institute Health Stroke Scale < 15, between 1 December 2016 and 30 June 2017...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
J C T Lau, A C Leong
The C-MAC® video monitor attachment is suitable for all otolaryngological scenarios, including post-operative follow up and difficult airway examination. Currently, there are no studies looking at the effectiveness of C-MAC® portable monitor with portable flexible nasoendoscopy. Our study demonstrates that the C-MAC® monitor with portable flexible nasoendoscopy is an excellent tool in terms of medical education, improving patient-doctor communication, efficiency of ward rounds and for medico-legal documentation, with distinct advantages over traditional direct flexible nasoendoscopy...
March 1, 2018: Clinical Otolaryngology
Takako Inoue, Yuji Tsuzuki, Etsuko Iio, Noboru Shinkai, Kayoko Matsunami, Kei Fujiwara, Kentaro Matsuura, Shunsuke Nojiri, Yasuhito Tanaka
This study aimed to assess the association between the serum glycobiomarker Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) for liver fibrosis and outcomes and carcinogenesis (HCC) in chronic hepatitis C (CHC) patients with advanced fibrosis. Serum WFA+ -M2BP levels were measured in 128 consecutive CHC patients including 49 HCC histopathologically diagnosed with advanced fibrosis (F3; 44, F4; 84) in our hospital. The median WFA+ -M2BP level was significantly higher in F4 than F3 patients (6...
February 28, 2018: Japanese Journal of Infectious Diseases
Jing Sun, Todd T Brown, David C Samuels, Todd Hulgan, Gypsyamber D'Souza, Beth D Jamieson, Kristine M Erlandson, Jeremy Martinson, Frank J Palella, Joseph B Margolick, Gregory D Kirk, Jennifer A Schrack
Background: Age-related gait speed decline is accelerated in men with HIV. Mitochondrial genetic variation is associated with frailty and mortality in the general population, and may provide insight into mechanisms of functional decline in people aging with HIV. Material & Methods: Gait speed was assessed semi-annually in the Multicenter AIDS Cohort Study (MACS). Mitochondrial DNA (mtDNA) haplogroups were extracted from genome-wide genotyping data, classifying men ≥ 50 years into 5 groups: mtDNA haplogroup H, J, T, Uk, and other...
February 22, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Shu C Chang, Kristen K Patton, Melissa R Robinson, Jeanne E Poole, Jordan M Prutkin
BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) requires pre-implant screening to ensure appropriate sensing and reduce risk of inappropriate shocks. Screening can be performed using either an ICD programmer or a 12 lead ECG machine. It is unclear whether differences in signal filtering and digital sampling change the screening success rate. METHODS: Subjects were recruited if they had a transvenous single lead ICD without pacing requirements or were candidates for a new ICD...
February 24, 2018: Pacing and Clinical Electrophysiology: PACE
Aleksi Sipola, Pekka Marttinen, Jukka Corander
Summary: The advent of genomic data from densely sampled bacterial populations has created a need for flexible simulators by which models and hypotheses can be efficiently investigated in the light of empirical observations. Bacmeta provides fast stochastic simulation of neutral evolution within a large collection of interconnected bacterial populations with completely adjustable connectivity network. Stochastic events of mutations, recombinations, insertions/deletions, migrations and microepidemics can be simulated in discrete non-overlapping generations with a Wright-Fisher model that operates on explicit sequence data of any desired genome length...
February 20, 2018: Bioinformatics
Vijay K Juneja, Tim B Mohr, Meryl Silverman, O Peter Snyder
The objective of this study was to assess the ability of Bacillus cereus spores to germinate and grow in order to determine a safe cooling rate for cooked rice, beans, and pasta, rice-chicken (4:1), rice-chicken-vegetables (3:1:1), rice-beef (4:1), and rice-beef-vegetables (3:1:1). Samples were inoculated with a cocktail of four strains of heat-shocked (80°C for 10 min) B. cereus spores (NCTC 11143, 935A/74, Brad 1, and Mac 1) to obtain a final spore concentration of approximately 2 log CFU/g. Thereafter, samples were exponentially cooled through the temperature range of 54...
February 23, 2018: Journal of Food Protection
Yuji Eso, Atsushi Takai, Kojiro Taura, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Hiroshi Seno
BACKGROUND AND AIM: Mac-2-binding protein glycosylation isomer (M2BPGi) was recently identified as a serum glycobiomarker for liver fibrosis. However, the relationship between M2BPGi and malnutrition in patients with chronic liver disease (CLD) is unknown. We aimed to evaluate whether M2BPGi could be a surrogate marker for malnutrition in patients with CLD. METHODS: In total, 338 outpatients with CLD were enrolled (median age: 67 years). We evaluated the associations among liver fibrosis markers (M2BPGi, FIB-4 index, and aspartate aminotransferase to platelet count ratio index), Child-Pugh stages, and nutritional status markers...
February 22, 2018: Journal of Gastroenterology and Hepatology
David J Olvera, David F E Stuhlmiller, Allen Wolfe, Charles F Swearingen, Troy Pennington, Daniel P Davis
INTRODUCTION: Airway management is a critical skill for air medical providers, including the use of rapid sequence intubation (RSI) medications. Mediocre success rates and a high incidence of complications has challenged air medical providers to improve training and performance improvement efforts to improve clinical performance. OBJECTIVES: The aim of this research was to describe the experience with a novel, integrated advanced airway management program across a large air medical company and explore the impact of the program on improvement in RSI success...
February 21, 2018: Prehospital Emergency Care
A Yu Zaytcev, K V Dubrovin, V A Svetlov
BACKGROUND: The development of modern video - and endoscopic equipment allows for revision and adjust to modern protocols for maintaining patency of the difficult airway, especially in maxillofacial or ENT -surgery. THE PURPOSE OF THE STUDY: Comparison the efficacy ofvarious methods of maintaining the airway patency in the practice of reconstructive maxillofacial surgery. MATERIALS AND METHODS: 89 patients, who were divided into 4 groups, were examined...
September 2017: Anesteziologiia i Reanimatologiia
M A Valizade Hasanloei, D Vahabzadeh, A Shargh, A Atmani, R Alizadeh Osalou
BACKGROUND & AIMS: Providing adequate and appropriate food and nutrients satisfying the patients' safe nutritional need is one of the most important care practices for critically ill patients (CIPs) in ICU settings, and is strongly related to the patients' safety. METHODS: In this prospective cross-sectional study data were collected from a 52-bed medical intensive care unit on 777 consecutive patients in six different ICUs. The patients' weights and heights were measured based on ulna length, knee height, MAC, Calf C, and Wrist C...
February 2018: Clinical Nutrition ESPEN
Changwon Yang, Whasun Lim, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
C-C motif chemokine ligand 2 (CCL2) is a small chemokine which belongs to the CC-type chemokine family, and has chemoattractant activity for recruitment of monocytes to sites of inflammation. Overexpressed CCL2 binding to its receptor C-C chemokine receptor 2 increases the risk of breast cancer in humans, but its effects on proliferation of bovine mammary epithelial cells is not known. Maintaining a high level of proliferative activity in bovine mammary epithelial cells during lactation is important for improving milk yield and can benefit the dairy industry economically...
February 14, 2018: Journal of Dairy Science
P Palumbo, S Usai, C Amatucci, B Perotti, L Ruggeri, G Illuminati, G Tellan
BACKGROUND: The extension of indications for procedures in a Day Surgery (DS) setting has led to changes in the anesthetic and surgical treatment of Inguinal Hernias (IH). According to the recommendations of the European Hernia Society, the treatment of IH in DS units should be performed under Monitored Anesthesia Care (MAC). PATIENTS AND METHODS: 960 patients underwent IH repairs over a period of 24 months. The patients were randomly divided into two groups: R (remifentanil) and F (fentanyl); the group F was considered as a control group...
November 2017: Il Giornale di Chirurgia
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