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JOURNAL ARTICLE
Emily Hargrave, Robin Alexander, Christine M Leeper, Julie C Leonard, Casandra D Josephson, Marie E Steiner, Philip C Spinella, Jennifer A Muszynski
Few data describe pediatric patients who receive massive transfusion for life-threatening hemorrhage (LTH) while on extracorporeal membrane oxygenation (ECMO). We present a retrospective secondary analysis of a multicenter prospective observational study to describe resource utilization and mortality in pediatric patients with LTH while on ECMO. Children who were on ECMO during an LTH were compared to children with LTH who were not on ECMO. Primary outcomes were volumes of blood products administered and 28 day mortality...
April 15, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#2
JOURNAL ARTICLE
Kristin J Dolan, Ayse Arikan, Anna M Banc-Husu, Muhammad Umair Mukhtar Mian, Sameer Thadani, Jeffrey Quinn Lee, Lacey Stribling, N Thao N Galván, John Goss, Rahul Baijal, Moreshwar S Desai
BACKGROUND: Intraoperative Continuous Renal Replacement Therapy (iCRRT) can prevent life-threatening complications, facilitate fluid management, and maintain metabolic homeostasis during liver transplantation (LT) in adults. There is a paucity of data in pediatric LT. We evaluated the safety, efficacy, and impact on survival of iCRRT in pediatric LT. METHODS: We conducted a retrospective cohort study of all children requiring CRRT pre-OLT at a quaternary children's hospital from 2014 to 2022...
April 2024: Clinical Transplantation
#3
JOURNAL ARTICLE
Elissa Abou Khalil, Erin Feeney, Katrina M Morgan, Philip C Spinella, Barbara A Gaines, Christine M Leeper
INTRODUCTION: Admission hypocalcemia has been associated with poor outcomes in injured adults. The impact of hypocalcemia on mortality has not been widely studied in pediatric trauma. METHODS: A pediatric trauma center database was queried retrospectively (2013-2022) for children age < 18 years who received blood transfusion within 24 hours of injury and had ionized calcium (iCal) level on admission. Children who received massive transfusion (>40 mL/kg) prior to hospital arrival or calcium prior to laboratory testing were excluded...
April 8, 2024: Journal of Trauma and Acute Care Surgery
#4
JOURNAL ARTICLE
Rachel Vaizer, Christine M Leeper, Liling Lu, Cassandra D Josephson, Julie C Leonard, Joshua B Brown, Philip C Spinella
INTRODUCTION: Transfusion may increase the risk of organ failure through immunomodulatory effects. The primary objective of this study was to assess for patient or transfusion-related factors that are independently associated with the risk of acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS) in a cohort of children with life-threatening bleeding from all etiologies. METHODS: In a secondary analysis of the prospective observational massive transfusion in children (MATIC) study, multivariable logistic regression was performed in an adjusted analysis to determine if blood product ratios or deficits were independently associated with AKI or ARDS in children with life-threatening bleeding...
March 21, 2024: Transfusion
#5
JOURNAL ARTICLE
Julia H Kolodziej, Philip C Spinella, Joshua B Brown, Liling Lu, Cassandra D Josephson, Julie C Leonard, Christine M Leeper
BACKGROUND: Recent data suggest female sex imparts a survival benefit after trauma in adults. The independent associations between patient sex and age with outcomes have not been examined in children with life-threatening hemorrhage (LTH) from all etiologies. STUDY DESIGN AND METHODS: In a secondary analysis of a multicenter prospective observational study of children with LTH, Massive Transfusion in Children (MATIC), we analyzed if patient sex and age were associated with differences in severity of illness, therapies, and outcomes...
March 21, 2024: Transfusion
#6
REVIEW
Anna Maeser, Malgorzata Biernacka-Zielinska, Elzbieta Smolewska
Macrophage activation syndrome (MAS) is one of the most severe complications of systemic juvenile idiopathic arthritis (sJIA). Around 10% of patients with sJIA exhibit systemic symptoms accompanied by macrophage activation syndrome (MAS), but it may occur subclinically in another 30-40%. In this article, we present a case of a 3-year-old girl diagnosed with sever MAS as an onset of sJIA complicated by disseminated intravascular coagulation (DIC). First symptoms of sJIA were observed about 5 months before setting the diagnose, and it was resembling urticaria...
March 19, 2024: Rheumatology International
#7
JOURNAL ARTICLE
Skye Clayton, Christine M Leeper, Mark H Yazer, Philip C Spinella
BACKGROUND: Low-titer group O whole blood (LTOWB) use is increasing due to data suggesting improved outcomes and safety. One barrier to use is low availability of RhD-negative LTOWB. This survey examined US hospital policies regarding the selection of RhD type of blood products in bleeding emergencies. STUDY DESIGN AND METHODS: A web-based survey of blood bank directors was conducted to determine their hospital's RhD-type selection policies for blood issued for massive bleeding...
March 19, 2024: Transfusion
#8
JOURNAL ARTICLE
Steven C Mehl, Adam M Vogel, Amy E Glasgow, Suzanne Moody, Meera Kotagal, Regan F Williams, Mark L Kayton, Emily C Alberto, Randall S Burd, Thomas J Schroeppel, Joanne E Baerg, Amanda Munoz, William B Rothstein, Laura A Boomer, Eric M Campion, Caitlin Robinson, Rachel M Nygaard, Chad J Richardson, Denise I Garcia, Christian J Streck, Michaela Gaffley, John K Petty, Cynthia Greenwell, Samir Pandya, Alicia M Waters, Robert T Russell, Brian K Yorkgitis, Jennifer Mull, Jeffrey Pence, Matthew T Santore, Taleen A MacArthur, Denise B Klinkner, Shawn D Safford, Tanya Trevilian, Megan Cunningham, Christa Black, Jessica Rea, Ryan G Spurrier, Aaron R Jensen, Bethany J Farr, David P Mooney, Bavana Ketha, Melvin S Dassinger, Anna Goldenberg-Sandau, Janika San Roman, Todd M Jenkins, Richard A Falcone, Stephanie F Polites
BACKGROUND: The benefit of targeting high ratio fresh frozen plasma (FFP):red blood cell (RBC) transfusion in pediatric trauma resuscitation is unclear as existing studies are limited to patients who retrospectively met criteria for massive transfusion. The purpose of this study is to evaluate the use of high ratio FFP:RBC transfusion and the association with outcomes in children presenting in shock. METHODS: A post-hoc analysis of a 24-institution prospective observational study (4/2018-9/2019) of injured children <18 years with elevated age-adjusted shock index was performed...
March 18, 2024: Journal of Trauma and Acute Care Surgery
#9
REVIEW
Khildan Miftahul Firdaus, Lucky Andriyanto, Adil Jihad Muhammad, Tatang Bisri
Craniosynostosis is a congenital condition characterized by the premature closure of one or more sutures in the skull after birth, often necessitating urgent surgical intervention. Nevertheless, cranial vault reconstruction surgery can cause rapid and massive blood loss. This procedure requires a blood transfusion, which entails potential hazards. In addition, the hemostatic system in children differs significantly from that in adults, resulting in increased bleeding during surgical procedures. We conducted a comprehensive literature review in the PubMed, Scopus, and Web of Science databases, referring to their inception for studies on the use of tranexamic acid in pediatric craniosynostosis surgery...
March 14, 2024: Cleft Palate-craniofacial Journal
#10
JOURNAL ARTICLE
Xiao-Xiao Lu, Yi Lu, Lin Yang, Yang-Yang Ma, Huan-Huan Wang
The patient was a male infant, born full-term, admitted to the hospital at 28 days of age due to jaundice for 20 days and abdominal distension for 15 days. The patient developed symptoms of jaundice, hepatosplenomegaly, massive ascites, and progressively worsening liver function leading to liver failure, severe coagulation disorders, and thrombocytopenia one week after birth. Various treatments were administered, including anti-infection therapy, fluid restriction, use of diuretics, use of hepatoprotective and choleretic agents, intermittent paracentesis, blood exchange, and intravenous immunoglobulin, albumin, and plasma transfusions...
February 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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JOURNAL ARTICLE
Galila Mokhtar, Amira Adly, Ashraf Abdel Baky, Dina Ezzat, Gehan Abdel Hakeem, Hoda Hassab, Ilham Youssry, Iman Ragab, Ivan Florez, Laila M Sherief, Magdy El-Ekiaby, Marwa Zakaria, Mervat Hesham, Naglaa Shaheen, Niveen Salama, Nouran Salah, Rasha A A Afifi, Rasha El-Ashry, Salwa Youssef, Seham Ragab, Sonia A Habib, Tarek Omar, Yasser Amer, Yasser Wali, Sara Makkeyah
Pediatric transfusion is a complex area of medicine covering a wide age range, from neonates to young adults. Compared to adult practice, there is a relative lack of high-quality research to inform evidence-based guidelines. We aimed to adapt the pre-existing high-quality practice guidelines for the transfusion of blood components in different pediatric age groups to be available for national use by general practitioners, pediatricians, and other health care professionals. The guideline panel included 17 key leaders from different Egyptian institutions...
April 2024: Annals of Hematology
#12
Filagot Mikru, Ayenew Gucho, Jiksa Muleta, Ermias Tilahun, Kalkidan Haile, Eden Belayneh
INTRODUCTION: Small bowel bleeding can be overt or occult. Despite advances in imaging and endoscopy, the diagnosis and treatment of small bowel bleeding remain challenging due to its length and location. Diagnostic procedures such as push enteroscopy, capsule endoscopy and intraoperative enteroscopy are recommended to identify the source of bleeding. CASE PRESENTATION: A 33-year-old female with no prior history of bleeding diathesis presented with massive lower GI bleeding...
February 2024: International Journal of Surgery Case Reports
#13
REVIEW
Elissa Abou Khalil, Katrina M Morgan, Barbara A Gaines, Philip C Spinella, Christine M Leeper
Balanced hemostatic resuscitation has been associated with improved outcomes in patients with both pediatric and adult trauma. Cold-stored, low-titer group O whole blood (LTOWB) has been increasingly used as a primary resuscitation product in trauma in recent years. Benefits of LTOWB include rapid, balanced resuscitation in one product, platelets stored at 4°C, fewer additives and fewer donor exposures. The major theoretical risk of LTOWB transfusion is hemolysis, however this has not been shown in the literature...
2024: Trauma Surgery & Acute Care Open
#14
JOURNAL ARTICLE
Yu-Li Wu, Lu Che, Yi-Qi Weng
Only limited information is available about the connection between massive blood transfusion and postoperative survival rates in pediatric liver transplantation. The aim of Gordon's study was to examine the potential impact of perioperative transfusion on postoperative complications and death in young children receiving pediatric living-donor liver transplantation (PLDLT). The authors concluded that transfusion of a red blood cell volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short- and long-term postoperative morbidity and mortality after PLDLT...
December 14, 2023: World Journal of Gastroenterology: WJG
#15
JOURNAL ARTICLE
Valérie Arsenault, Lani Lieberman, Pegah Akbari, Kimmo Murto
PURPOSE: Hemorrhage is the leading cause of pediatric death in trauma and cardiac arrest during surgery. Adult studies report improved patient outcomes using massive hemorrhage protocols (MHPs). Little is known about pediatric MHP adoption in Canada. METHODS: After waived research ethics approval, we conducted a survey of Canadian pediatric tertiary care hospitals to study MHP activations. Transfusion medicine directors provided hospital/patient demographic and MHP activation data...
December 6, 2023: Canadian Journal of Anaesthesia
#16
REVIEW
Blood Product Transfusions for Children in the Perioperative Period and for Critically Ill Children.
Eva Wittenmeier, Florian Piekarski, Andrea U Steinbicker
BACKGROUND: Approximately 1% to 2% of all hospitalized children receive a transfusion of blood products, in Germany as in other countries. High-quality scientific evidence on transfusions in children is scarce. The available evidence is discussed in this review. METHODS: This review is based on publications on blood product transfusions in children that were retrieved by a literature search, including clinical studies, international guideline recommendations, the recommendations of the German cross-sectional guideline, and results of other recent, relevant publications...
January 26, 2024: Deutsches Ärzteblatt International
#17
JOURNAL ARTICLE
Justin Gerard, Jan-Michael Van Gent, Jessica Cardenas, Christian Gage, David E Meyer, Charles Cox, Charles E Wade, Bryan A Cotton
OBJECTIVES: Recent studies evaluating fibrinogen replacement in trauma, along with newly available fibrinogen-based products, has led to an increase in debate on where products such as cryoprecipitate belong in our resuscitation strategies. We set out to define the phenotype and outcomes of those with hypofibrinogenemia and evaluate whether fibrinogen replacement should have a role in the initial administration of massive transfusion. METHODS: All patients <18 years of age presenting to our trauma center 11/17-4/21 were reviewed...
2023: Trauma Surgery & Acute Care Open
#18
Caroline Lim, Charles Tsung-Che Hsieh, Siew Yen Lai, Yi-Tzu Chu, Ming Chen, Hsin-Hung Wu
OBJECTIVE: Amniotic fluid embolism is one of the most serious pregnancy complications. It can cause sudden maternal collapse with high mortality and morbidity. We present a case report regarding the important of prompt decision making and multidisciplinary team work for management of amniotic fluid embolism to yield favorable maternal and neonatal outcome. CASE REPORT: This is a 35-year-old, gravida 2, para 1, woman underwent labor induction at gestational age of 37 + 6 weeks due to elective induction...
November 2023: Taiwanese Journal of Obstetrics & Gynecology
#19
JOURNAL ARTICLE
Morihiro Katsura, Shingo Fukuma, Akira Kuriyama, Yutaka Kondo, Hideto Yasuda, Kazuhide Matsushima, Atsushi Shiraishi, Akari Kusaka, Yosuke Nakabayashi, Masayuki Yagi, Fumihito Ito, Atsushi Tanikawa, Shigeki Kushimoto
BACKGROUND: This study aimed to assess whether the grade of contrast extravasation (CE) on CT scans was associated with massive transfusion (MT) requirements in pediatric blunt liver and/or spleen injuries (BLSI). METHODS: This multicenter retrospective cohort study included pediatric patients (≤16 years old) who sustained BLSI between 2008 and 2019. MT was defined as transfusion of all blood products ≥40 mL/kg within the first 24 h of admission...
November 4, 2023: Journal of Pediatric Surgery
#20
JOURNAL ARTICLE
Makoto Aoki, Morihiro Katsura, Kazuhide Matsushima
OBJECTIVE: To assess the association between whole blood (WB) and mortality among injured children who received immediate blood transfusion. BACKGROUND: The use of WB for transfusion therapy in trauma has been revisited, and recent studies have reported an association between WB and improved survival among adults. However, evidence of a similar association lacks in children. METHODS: We performed a retrospective cohort study from the ACS-TQIP between 2020 and 2021...
November 6, 2023: Annals of Surgery
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