keyword
https://read.qxmd.com/read/37883460/prediction-model-for-in-hospital-mortality-in-patients-at-high-altitudes-with-ards-due-to-covid-19
#1
JOURNAL ARTICLE
David Rene Rodriguez Lima, Cristhian Rubio Ramos, Andrés Felipe Yepes Velasco, Leonardo Andrés Gómez Cortes, Darío Isaías Pinilla Rojas, Ángela María Pinzón Rondón, Ángela María Ruíz Sternberg
INTRODUCTION: The diagnosis of acute respiratory distress syndrome (ARDS) includes the ratio of pressure arterial oxygen and inspired oxygen fraction (P/F) ≤ 300, which is often adjusted in locations more than 1,000 meters above sea level (masl) due to hypobaric hypoxemia. The main objective of this study was to develop a prediction model for in-hospital mortality among patients with ARDS due to coronavirus disease 2019 (COVID-19) (C-ARDS) at 2,600 masl with easily available variables at patient admission and to compare its discrimination capacity with a second model using the P/F adjusted for this high altitude...
2023: PloS One
https://read.qxmd.com/read/37311630/impact-of-high-flow-nasal-cannula-use-in-subjects-with-covid-19-ards-at-high-altitudes-clinical-presentation-and-prognostic-factors
#2
JOURNAL ARTICLE
Daniel Molano-Franco, Antonio Viruez-Soto, Mario Gomez, Edgar Beltran, Mario Villabon, Angela Sosa, Leidy Ortiz, Estefania Orozco, Alejandra Hurtado, Lida Sanchez, Christian Arias-Reyes, Jorge Soliz, Joan R Masclans
BACKGROUND: High-flow nasal cannula (HFNC) reduces the need for intubation in adult subject with acute respiratory failure. Changes in hypobaric hypoxemia have not been studied for subject with an HFNC in ICUs at altitudes > 2,600 m above sea level. In this study, we investigated the efficacy of HFNC treatment in subjects with COVID-19 at high altitudes. We hypothesized that progressive hypoxemia and the increase in breathing frequency associated with COVID-19 in high altitudes affect the success of HFNC therapy and may also influence the performance of the traditionally used predictors of success and failure...
June 13, 2023: Respiratory Care
https://read.qxmd.com/read/36568319/high-altitude-pulmonary-edema-at-2640-m-altitude-associated-with-an-acute-rhinovirus-infection-first-case-in-the-literature
#3
Diego Alejandro Cubides Diaz, Natalia Muñoz Angulo, Luz Adriana Herrera Alzate, Daniel Martin Arsanios, Ana Lucía Ovalle Monroy, Omar Velandia, Carlos Mauricio Calderón Vargas
High altitude pulmonary edema (HAPE) is a multifactorial condition that may occur after ascent of high altitudes, especially in genetic predisposed individuals. Diagnosis is challenging and could lead to potentially lethal complications such as acute respiratory distress syndrome (ARDS). We present one of the few reported cases of HAPE below 3000 m of altitude, and the first to our knowledge to present with a concomitant acute Rhinovirus infection, precipitating and complicating the diagnosis and clinical course...
2023: Respiratory Medicine Case Reports
https://read.qxmd.com/read/35131011/-feasibility-of-pulse-oxygen-saturation-for-the-condition-evaluation-of-acute-respiratory-distress-syndrome-patients-in-the-lijiang-region
#4
JOURNAL ARTICLE
Xiao Yang, Lu Diao, Yaowu Chen, Yifeng Chen, Dongmei Dai, Leyun Xiaoli, Ying Wang, Wangbin Xu
OBJECTIVE: To explore the feasibility of using pulse oxygen saturation (SpO2 ) to evaluate the condition of patients with acute respiratory distress syndrome (ARDS) in the Lijiang region. METHODS: Patients with ARDS who visited the department of emergency of People's Hospital of Lijiang from August to December 2020 were selected as study subjects. Patients were divided by severity into mild ARDS group [200 mmHg (1 mmHg = 0.133 kPa) ≤ oxygenation index (PaO2 /FiO2 , P/F) ≤ 300 mmHg] and moderate to severe ARDS group (P/F ≤ 200 mmHg)...
December 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/34412752/-comparison-of-pulse-oxygen-saturation-fraction-of-inhaled-oxygen-and-arterial-partial-pressure-of-oxygen-fraction-of-inhaled-oxygen-in-the-assessment-of-oxygenation-in-acute-respiratory-distress-syndrome-patients-at-different-high-altitudes-in-yunnan-province
#5
JOURNAL ARTICLE
Wangbin Xu, Chunming Li, Yaowu Chen, Huanan Duan, Lu Diao, Xiao Yang, Dongmei Dai, Leyun Xiao-Li, Fei Wang
OBJECTIVE: To investigate and evaluate if pulse oxygen saturation/fraction of inhaled oxygen (SpO2 /FiO2 ) can be used, as replacement of arterial partial pressure of oxygen/fraction of inhaled oxygen (PaO2 /FiO2 ), to assess oxygenation in acute respiratory distress syndrome (ARDS) patients at different high altitudes in Yunnan Province, and to find a rapid and non-invasive method for the diagnosis of ARDS at different altitudes. METHODS: Patients with ARDS at different high altitudes in Yunnan Province from January 2019 to December 2020 were enrolled...
July 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/34316147/radiographical-spectrum-of-high-altitude-pulmonary-edema-a-pictorial-essay
#6
JOURNAL ARTICLE
Uday Yanamandra, Vasu Vardhan, Puneet Saxena, Priyanka Singh, Amul Gupta, Deepak Mulajkar, Rajan Grewal, Velu Nair
Background: High-altitude pulmonary edema (HAPE) is a common cause of hospitalization in high altitude areas with significant morbidity. The clinical presentation of HAPE can overlap with a broad spectrum of cardiopulmonary diseases. Also, it is associated with varied radiological manifestations mimicking other conditions and often leading to unnecessary and inappropriate treatment. Patients and methods: The primary aim of the study was to study the various radiological manifestations of HAPE through real-world chest radiographs...
June 2021: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/33978479/return-to-high-altitude-after-recovery-from-coronavirus-disease-2019
#7
JOURNAL ARTICLE
Andrew M Luks, Colin K Grissom
Luks, Andrew M. and Colin K. Grissom. Return to high altitude after recovery from coronavirus disease 2019. High Alt Med Biol. 00:000-000, 2021.-With the increasing availability of coronavirus disease 2019 (COVID-19) vaccines and the eventual decline in the burden of the disease, it is anticipated that all forms of tourism, including travel to high altitude, will rebound in the near future. Given the physiologic challenges posed by hypobaric hypoxia at high altitude, it is useful to consider whether high-altitude travel will pose risks to those previously infected with severe acute respiratory syndrome coronavirus 2, particularly those with persistent symptoms after resolution of their infection...
May 11, 2021: High Altitude Medicine & Biology
https://read.qxmd.com/read/33729133/-continuous-prone-position-ventilation-in-patients-with-severe-acute-respiratory-distress-syndrome-at-high-altitude
#8
JOURNAL ARTICLE
Jinhai Han, Siqing Ma, Bin Sun, Hao Wang, Xiaolin Sun, Guibin Jia
OBJECTIVE: To investigate the therapeutic effect of different prone position ventilation (PPV) on patients with severe acute respiratory distress syndrome (ARDS) at high altitude. METHODS: The severe ARDS patients who met the Berlin standard admitted to the department of intensive care unit (ICU) of Qinghai Provincial People's Hospital from January 2017 to January 2020 were enrolled. The patients with classic PPV treatment (i.e. alternate prone supine position, about 16 hours per day) were included in the discontinuous PPV group; the patients with modified PPV treatment (i...
February 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/33340275/altitude-and-covid-19-friend-or-foe-a-narrative-review
#9
REVIEW
Grégoire P Millet, Tadej Debevec, Franck Brocherie, Martin Burtscher, Johannes Burtscher
Recent reports suggest that high-altitude residence may be beneficial in the novel coronavirus disease (COVID-19) implicating that traveling to high places or using hypoxic conditioning thus could be favorable as well. Physiological high-altitude characteristics and symptoms of altitude illnesses furthermore seem similar to several pathologies associated with COVID-19. As a consequence, high altitude and hypoxia research and related clinical practices are discussed for potential applications in COVID-19 prevention and treatment...
January 2021: Physiological Reports
https://read.qxmd.com/read/32344310/respiratory-conditions-in-coronavirus-disease-2019-covid-19-important-considerations-regarding-novel-treatment-strategies-to-reduce-mortality
#10
JOURNAL ARTICLE
Mark R Geier, David A Geier
A novel virus named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) causes symptoms that are classified as coronavirus disease (COVID-19). Respiratory conditions are extensively described among more serious cases of COVID-19, and the onset of acute respiratory distress syndrome (ARDS) is one of the hallmark features of critical COVID-19 cases. ARDS can be directly life-threatening because it is associated with low blood oxygenation levels and can result in organ failure. There are no generally recognized effective treatments for COVID-19, but treatments are urgently needed...
July 2020: Medical Hypotheses
https://read.qxmd.com/read/32226695/acetazolamide-nifedipine-and-phosphodiesterase-inhibitors-rationale-for-their-utilization-as-adjunctive-countermeasures-in-the-treatment-of-coronavirus-disease-2019-covid-19
#11
REVIEW
Isaac Solaimanzadeh
Effective treatments for Coronavirus Disease 2019 (COVID-19) outbreak are urgently needed. While anti-viral approaches and vaccines are being considered immediate countermeasures are unavailable. The aim of this article is to outline a perspective on the pathophysiology of COVID-19 in the context of the currently available clinical data published in the literature. This article appreciates clinical data published on COVID-19 in the context of another respiratory illness - high altitude pulmonary edema (HAPE)...
March 20, 2020: Curēus
https://read.qxmd.com/read/32203609/expression-of-high-mobility-group-box-1-protein-in-a-polytrauma-model-during-ground-transport-and-simulated-high-altitude-evacuation
#12
JOURNAL ARTICLE
Jae Hyek Choi, Teryn R Roberts, Kyle Sieck, George T Harea, Vitali Karaliou, Daniel S Wendorff, Brendan M Beely, Leopoldo C Cancio, Valerie G Sams, Andriy I Batchinsky
BACKGROUND: We investigated the expression of high mobility group box 1 (HMGB1) protein in a combat-relevant polytrauma/ acute respiratory distress syndrome (ARDS) model. We hypothesized that systemic HMGB1 expression is increased after injury and during aeromedical evacuation (AE) at altitude. METHODS: Female Yorkshire swine (n =15) were anesthetized and cannulated with a 23Fr dual-lumen catheter. Venovenous extracorporeal life support (VV ECLS) was initiated via the right jugular vein and carried out with animals uninjured on day 1 and injured by bilateral pulmonary contusion on day 2...
2020: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://read.qxmd.com/read/29714090/substrate-stiffness-dependent-exacerbation-of-endothelial-permeability-and-inflammation-mechanisms-and-potential-implications-in-ali-and-ph-2017-grover-conference-series
#13
JOURNAL ARTICLE
Pratap Karki, Anna A Birukova
The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular leak associated with pneumonia, pulmonary edema resulting from inhalation of toxins, acute elevation to high altitude, traumatic and septic lung injury, acute lung injury (ALI), and its life-threatening complication, acute respiratory distress syndrome (ARDS). In addition to the long-known edemagenic and inflammatory agonists, emerging evidences suggest that factors of endothelial cell (EC) mechanical microenvironment such as blood flow, mechanical strain of the vessel, or extracellular matrix stiffness also play an essential role in the control of endothelial permeability and inflammation...
April 2018: Pulmonary Circulation
https://read.qxmd.com/read/23040775/-effect-of-prone-position-on-the-oxygenation-of-patients-with-acute-respiratory-distress-syndrome-after-failure-recruitment-maneuvers-at-high-altitudes
#14
RANDOMIZED CONTROLLED TRIAL
Wen-xin Wang, Bo Xu, Hu-sai Ma, Jian-bin Meng
OBJECTIVE: To assess the effect of prone position on the oxygenation of patients with acute respiratory distress syndrome (ARDS) after recruitment maneuvers (RM) failure at high altitudes. METHODS: Forty-one ARDS patients who were invalid for RM therapy at the altitude of 2260 metres area hospital were enrolled[mean oxygenation index (PaO(2)/FiO(2)) increased than RM<20% considered as RM invalid]. All were divided into acute respiratory distress syndrome (ARDSp) and extra-acute respiratory distress syndrome (ARDSexp) based on different etiology, and each group was randomly divided into the supine and the prone position group, i...
October 2012: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, Chinese Critical Care Medicine, Zhongguo Weizhongbing Jijiuyixue
https://read.qxmd.com/read/22717263/effects-of-species-diverse-high-alpine-forage-on-in-vitro-ruminal-fermentation-when-used-as-donor-cow-s-feed-or-directly-incubated
#15
JOURNAL ARTICLE
R Khiaosa-Ard, C R Soliva, M Kreuzer, F Leiber
Alpine forages are assumed to have specific effects on ruminal digestion when fed to cattle. These effects were investigated in an experiment from two perspectives, either by using such forages as a substrate for incubation or as feed for a rumen fluid donor cow. In total, six 24-h in vitro batch culture runs were performed. Rumen fluid was collected from a non-lactating donor cow after having grazed pastures at ∼2000 m above sea level for 2, 6 and 10 weeks. These 'alpine runs' were compared with three lowland samplings from before and 2 and 6 weeks after the alpine grazing where a silage-concentrate mix was fed...
November 2012: Animal
https://read.qxmd.com/read/18269195/hypoxic-inhibition-of-alveolar-fluid-reabsorption
#16
REVIEW
Laura A Dada, Jacob I Sznajder
Alveolar hypoxia occurs during ascent to high altitude and is also observed in patients with ARDS and acute hypoxemic respiratory failure, in which alveolar flooding is associated with a decrease in edema fluid clearance and increased mortality. The mechanisms that lead to the impairment of alveolar fluid clearance are not completely understood. Alveolar fluid reabsorption is accomplished mostly by active Na+ transport across the alveolar epithelium which creates an osmotic gradient responsible for the clearance of lung edema from the alveolar spaces...
2007: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/15836825/-criteria-suitable-for-diagnosis-of-acute-respiratory-distress-syndrome-multiple-organ-dysfunction-syndrome-at-moderately-high-altitude-area
#17
COMPARATIVE STUDY
Shi-fan Zhang, De-hai Zhang, Hui-ping Liu, Wei Gao, Xiao-hong Luo, Jian-ying Wu, Shu-xin Lin, Chuan-lan Liu, Xian-ying Zhang, Tian-duo Chen
OBJECTIVE: To compare the diagnostic parameters of acute respiratory distress syndrome/multiple organ dysfunction syndrome (ARDS/MODS) at high altitude (H-ARDS/MODS) with that on plain, and to establish a more practical diagnostic criterion of H-ARDS/MODS. METHODS: Five hundred and five cases fulfilled the criteria for the diagnosis of ARDS/MODS were divided into three groups according to the altitude of their habitation: control group including inhabitants (<430 m) on plain (CG, n=113), moderate high altitude group 1 inhabitants at the altitude of 1,517 m (H1G, n=314), moderate high altitude group 2 inhabitants at the altitude of 2,261 m to 2,400 m (H2G, n=78)...
April 2005: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, Chinese Critical Care Medicine, Zhongguo Weizhongbing Jijiuyixue
https://read.qxmd.com/read/15491538/-altitude-the-ratio-of-pao2-to-fraction-of-inspired-oxygen-and-shunt-impact-on-the-assessment-of-acute-lung-injury
#18
JOURNAL ARTICLE
J R Pérez-Padilla
The ratio of PaO2 to the fraction of inspired oxygen (PaO2/FIO2) is commonly used to determine the severity of acute lung injury and acute respiratory distress syndrome (ARDS). The research presented here used computational models of the lung to analyze the effect of altitude on the PaO2/FIO2 ratio and pulmonary shunt. At a given shunt, the PaO2/FIO2 ratio is lower at higher altitudes. Therefore, when evaluating for ARDS based on a PaO2/FIO2 ratio of <200 mm Hg, patients residing at high altitudes will have less shunt and, presumably, less severe lung injury than patients at sea level...
October 2004: Archivos de Bronconeumología
https://read.qxmd.com/read/12831625/-study-of-diagnostic-criteria-of-acute-respiratory-distress-syndrome-and-multiple-organ-dysfunction-syndrome-at-high-altitude-revised-draft-of-the-diagnostic-criteria-of-high-acute-respiratory-distress-syndrome-drawn-in-lanzhou-conference
#19
JOURNAL ARTICLE
Shi-fan Zhang, De-hai Zhang, Hui-ping Liu, Ga Da, Wei Gao, Shu-xin Lin, Tian-duo Chen, Fen-xue Liu, Chuan-lan Liu
OBJECTIVE: To compare the difference of the diagnostic parameters of acute respiratory distress syndrome/multiple organ dysfunction syndrome (ARDS/MODS) at high altitude (H-ARDS/MODS) with that on plains and reevaluate the practicality and feasibility of the diagnostic criteria of H-ARDS (Lanzhou conference, 1999). METHODS: Three hundred and sixty cases with relatively complete data were divided into three groups according to their originating altitude: control group on plains (CG, n=93), high altitude group 1 at the altitude of 1,517 m (H1G, n=223), high altitude group 2 at the altitude of 2,261-2,400 m (H2G, n=44)...
March 2003: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, Chinese Critical Care Medicine, Zhongguo Weizhongbing Jijiuyixue
https://read.qxmd.com/read/12424482/morphological-changes-of-carotid-bodies-in-acute-respiratory-distress-syndrome-a-morphometric-study-in-humans
#20
JOURNAL ARTICLE
E N G Vinhaes, M Dolhnikoff, P H N Saldiva
Carotid bodies are chemoreceptors sensitive to a fall of partial oxygen pressure in blood (hypoxia). The morphological alterations of these organs in patients with chronic obstructive pulmonary disease (COPD) and in people living at high altitude are well known. However, it is not known whether the histological profile of human carotid bodies is changed in acute clinical conditions such as acute respiratory distress syndrome (ARDS). The objective of the present study was to perform a quantitative analysis of the histology of carotid bodies collected from patients who died of ARDS...
October 2002: Brazilian Journal of Medical and Biological Research
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