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https://www.readbyqxmd.com/read/28218824/decreased-home-cage-movement-and-oromotor-impairments-in-adult-fmr1-ko-mice
#1
Stephen J Bonasera, Tammy R Chaudoin, Evan H Goulding, Mateusz Mittek, Anna Dunaevsky
Fragile X syndrome (FXS) is a common inherited disorder that significantly impacts family and patient day-to-day living across the entire lifespan. The childhood and adolescent behavioral consequences of FXS are well-appreciated. However, there are significantly fewer studies (except those examining psychiatric comorbidities) assessing behavioral phenotypes seen in adults with FXS. Mice engineered with a genetic lesion of Fmr1 recapitulate important molecular and neuroanatomical characteristics of FXS, and provide a means to evaluate adult behavioral phenotypes associated with FXS...
February 20, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28202303/association-between-substance-use-diagnoses-and-psychiatric-disorders-in%C3%A2-an-adolescent-and-young-adult-clinic-based-population
#2
Justine Wittenauer Welsh, John R Knight, Sherry Shu-Yeu Hou, Monica Malowney, Patricia Schram, Lon Sherritt, J Wesley Boyd
PURPOSE: Adolescents with substance use disorders are more likely to have a current psychiatric disorder. However, when compared with the adult literature, there is relatively limited information regarding the specific co-occurrence of certain mental health diagnoses and substance use disorders in adolescents. The objectives of this study were to build on the previous literature regarding mental health diagnoses and different types of substance use disorders in adolescents, as well as explore the differences, if any, between groupings of mental health diagnosis and type of substance used...
February 12, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28199068/the-relationship-between-stressful-life-events-and-axis-i-diagnoses-among-adolescent-offspring-of-probands-with-bipolar-and-non-bipolar-psychiatric-disorders-and-healthy-controls-the-pittsburgh-bipolar-offspring-study-bios
#3
Lisa A Pan, Tina R Goldstein, Brian T Rooks, Mary Hickey, Jie Yu Fan, John Merranko, Kelly Monk, Rasim S Diler, Dara J Sakolsky, Daniella Hafeman, Satish Iyengar, Benjamin Goldstein, David J Kupfer, David A Axelson, David A Brent, Boris Birmaher
BACKGROUND: Previous studies have explored the role of stressful life events in the development of mood disorders. We examined the frequency and nature of stressful life events as measured by the Stressful Life Events Schedule (SLES) among 3 groups of adolescent offspring of probands with bipolar (BD), with non-BD psychiatric disorders, and healthy controls. Furthermore, we examined the relationship between stressful life events and the presence of DSM-IV Axis I disorders in these offspring...
February 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28198454/preliminary-evidence-for-a-role-of-the-adrenergic-nervous-system-in-generalized-anxiety-disorder
#4
Xiaobin Zhang, Joanna Norton, Isabelle Carrière, Karen Ritchie, Isabelle Chaudieu, Joanne Ryan, Marie-Laure Ancelin
Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (ADRs) with GAD, with the involvement of stressful events. Data were obtained from 844 French community-dwelling elderly aged 65 or over. Anxiety disorders were assessed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196999/indian-psychiatric-society-multicentric-study-correlates-of-prescription-patterns-of-psychotropics-in-india
#5
Sandeep Grover, Ajit Avasthi, Vishal Sinha, Bhavesh Lakdawala, Manish Bathla, Sujata Sethi, D M Mathur, Puneet Kathuria, Sandip Shah, D Sai Baalasubramanian, Vivek Agarwal, Kamla Deka
BACKGROUND: There is a lack of information on the clinical and sociodemographic correlates of prescription of psychotropics by psychiatrists. AIM AND OBJECTIVE: This study aimed to evaluate the relationship of prescription patterns with various clinical and sociodemographic variables. METHODOLOGY: Data of prescription patterns, psychiatric diagnosis, sociodemographic variables, and comorbid physical illnesses were collected for 4480 patients, across 11 centers...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28196789/the-relationship-of-disordered-eating-attitudes-with-stress-level-bone-turnover-markers-and-bone-mineral-density-in-obese-adolescents
#6
Aslı Okbay Güneş, Müjgan Alikaşifoğlu, Ezgi Şen Demirdöğen, Ethem Erginöz, Türkay Demir, Mine Kucur, Oya Ercan
OBJECTIVE: To investigate the effect of stress caused by disordered eating attitudes on bone health in obese adolescents. METHODS: A cross-sectional study comprising 80 obese adolescents was performed from November 2013 to September 2014. Twenty-four-hour urinary free cortisol levels were measured as a biological marker of stress. Bone turnover was evaluated using bone-specific alkaline phosphatase, serum osteocalcin, and urinary N-telopeptide measurements. Bone mineral density was measured using dual-energy X-ray absorptiometry...
February 15, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28173735/evaluation-of-the-essences-in-a-neurodevelopmental-inpatient-service-for-adolescents
#7
Ciara Glennon, Marilyn A Sher
Ward climate is a key element within psychiatric settings, associated with positive clinical outcomes. The Essen Climate Evaluation Schema (EssenCES) is a ward climate measure, which is validated for use within UK forensic settings. It has been studied within neurodevelopmental psychiatric inpatient settings with mixed findings on its appropriateness, and there is a dearth of EssenCES research which has been conducted within an adolescent psychiatric inpatient setting. The present study piloted the EssenCES within an inpatient psychiatric neurodevelopmental setting for adolescents in the East of England, in order to explore its usefulness within this setting and to provide preliminary normative data for a child and adolescent mental health services inpatient learning disability population...
January 1, 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/28169823/-empathy-deficit-in-adolescents-160-how-to-characterize-and-evaluate-it-clinically-160-a-litterature-review
#8
Mélanie Piñon, Aline Forestier, Marc Diby
<ce:para>Introduction : empathy has been considered since a long time under the angle of human sciences. Today, certain neuro-scientific postulates complement this knowledge.</ce:para><ce:para>Context : observation of adolescents presenting psychiatric disorders, accompagnied by conduct disorders and/or psychopathic traits, frequently describe empathy deficits ; nurses should evaluate the nature and the degree of empathy of these adolescents.</ce:para><ce:para>Aims : this litterature review aims to expose the clinical characteristics of empathy deficit from its definition and to describe the clinical evaluation tools...
July 5, 2016: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/28153208/morbidity-of-childhood-onset-narcolepsy-a-controlled-national-study
#9
Poul Jennum, Line Pickering, Eva Wiberg Thorstensen, Rikke Ibsen, Jakob Kjellberg
: Narcolepsy is associated with significant morbidities. We evaluated the morbidities and mortality in a national group of child and adolescent patients after a first diagnosis of narcolepsy. METHODS: Identified from the Danish National Patient Registry (NPR), 243 patients (128 boys) aged 0-19 years diagnosed with narcolepsy between 1998 and 2012 with follow-up until 2014 were compared with 970 controls who were randomly chosen from the Danish Civil Registration System Statistics and matched by age, gender and geography...
January 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28148729/psychiatric-disorders-in-adolescents-with-single-ventricle-congenital-heart-disease
#10
David R DeMaso, Johanna Calderon, George A Taylor, Jennifer E Holland, Christian Stopp, Matthew T White, David C Bellinger, Michael J Rivkin, David Wypij, Jane W Newburger
BACKGROUND AND OBJECTIVES: Mental health outcomes for survivors of critical congenital heart disease (CHD) remain under-investigated. We sought to examine psychiatric disorders and psychosocial functioning in adolescents with single ventricle CHD and to explore whether patient-related risk factors predict dysfunction. METHODS: This cohort study recruited 156 adolescents with single ventricle CHD who underwent the Fontan procedure and 111 healthy referents. Participants underwent comprehensive psychiatric evaluation including a clinician-rated psychiatric interview and parent- and self-report ratings of anxiety, disruptive behavior, including attention-deficit/hyperactivity disorder (ADHD), and depressive symptoms...
February 1, 2017: Pediatrics
https://www.readbyqxmd.com/read/28141730/-footprints-in-the-bathroom-the-role-of-spirituality-in-patient-diagnosis
#11
Veronica Meneses, Douglas Vanderbilt, Linda Barnes, Marilyn Augustyn
Lucy is a 12-year-old Latina whose mother brought her to the pediatric clinic for help with her anxiety symptoms, "hearing voices," and episodes of "spacing out." Lucy did not cry at birth secondary to vocal cord paralysis and still has the tracheostomy performed at a few days of life. In addition to her neonatal intensive care unit stay, she has been hospitalized for pneumonia. Her mother says she is "sickly" and has a weak immune system due to her asthma symptoms. Lucy also experiences somatic complaints related to gastroesophageal reflux and constipation...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28141713/developmental-regression-depression-and-psychosocial-stress-in-an-adolescent-with-down-syndrome
#12
David S Stein, Kerim M Munir, Andrea J Karweck, Emily J Davidson, Martin T Stein
Kristen is a 13-year-old girl with Down syndrome (DS) who was seen urgently with concerns of cognitive and developmental regression including loss of language, social, and toileting skills. The evaluation in the DS clinic focused on potential medical diagnoses including atlantoaxial joint instability, vitamin deficiency, obstructive sleep apnea (OSA), and seizures. A comprehensive medical evaluation yielded only a finding of moderate OSA. A reactive depression was considered in association with several psychosocial factors including moving homes, entering puberty/onset of menses, and classroom change from an integrated setting to a self- contained classroom comprising unfamiliar peers with behavior challenges...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28138979/an-evaluation-of-the-use-and-efficacy-of-a-sensory-room-within-an-adolescent-psychiatric-inpatient-unit
#13
Monique West, Glenn Melvin, Francis McNamara, Michael Gordon
BACKGROUND/AIM: The introduction of sensory rooms within acute psychiatric settings provides a therapeutic space that promotes emotional self-regulation and reduces distress and disruptive behaviours. The current research investigated the clinical benefit of a sensory room within an adolescent psychiatric unit. It examined whether guided sensory room use can reduce distress for adolescents and identified characteristics of sensory room users. Seclusion rates 12 months pre- and post-sensory room introduction were compared...
January 31, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28112539/long-acting-injectable-antipsychotics-in-children-and-adolescents
#14
Sarah Lytle, Molly McVoy, Martha Sajatovic
OBJECTIVE: While a number of articles have reviewed the use of long-acting injectable antipsychotics (LAIs) in first-episode psychosis, there has been extremely limited focus on LAIs in children and adolescents. This review of the literature evaluated use of LAIs in children and youth under the age of 18. METHODS: We conducted a comprehensive search of the PubMed, PsychINFO, CINAHL, and EMBASE databases using keywords related to LAIs, children, and psychiatric conditions, including schizophrenia, bipolar disorder, and schizoaffective disorder...
February 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28111871/turning-the-tides-coping-with-trauma-and-addiction-through-residential-adolescent-group-therapy
#15
Katherine Gardner Bougard, Tina Marie Truncellito Laupola, Joan Parker-Dias, Jeremy Creekmore, Stacey Stangland
TOPIC: Evidence-based group therapy in an inpatient setting that provides an integrated treatment approach for both trauma and addiction in female adolescents. PURPOSE: The purpose of this evidence-based practice (EBP) project was to implement and assess the impact of an integrated group therapy approach for both posttraumatic stress disorder (PTSD) and substance use disorder (SUD) in adolescent females as part of a residential treatment program. SOURCES: The Iowa Model of EBP guided this EBP project...
November 2016: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/28096898/characteristics-of-adolescents-frequently-restrained-in-acute-psychiatric-units-in-norway-a-nationwide-study
#16
Astrid Furre, Ragnhild Sørum Falk, Leiv Sandvik, Svein Friis, Maria Knutzen, Ketil Hanssen-Bauer
BACKGROUND: The use of restraints in adolescent psychiatric settings requires particular professional, ethical, and legal considerations. The purpose of this study was to investigate whether the number of restraint episodes per patient was related to any of several characteristics of the adolescents. METHODS: In this nationwide study, we included all adolescents restrained during the period 2008-2010 (N = 267) in Norwegian adolescent acute psychiatric inpatient units...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28094813/a-methylome-wide-mqtl-analysis-reveals-associations-of-methylation-sites-with-gad1-and-hdac3-snps-and-a-general-psychiatric-risk-score
#17
D M Ciuculete, A E Boström, S Voisin, H Philipps, O E Titova, M Bandstein, L Nikontovic, M J Williams, J Mwinyi, H B Schiöth
Genome-wide association studies have identified a number of single-nucleotide polymorphisms (SNPs) that are associated with psychiatric diseases. Increasing body of evidence suggests a complex connection of SNPs and the transcriptional and epigenetic regulation of gene expression, which is poorly understood. In the current study, we investigated the interplay between genetic risk variants, shifts in methylation and mRNA levels in whole blood from 223 adolescents distinguished by a risk for developing psychiatric disorders...
January 17, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28093195/health-and-functioning-of-adolescents-conceived-by-assisted-reproductive-technology
#18
Eyal Fruchter, Ronit Beck-Fruchter, Ariel Hourvitz, Mark Weiser, Shira Goldberg, Daphna Fenchel, Liat Lerner-Geva
OBJECTIVE: To evaluate the general health, mental health, and cognitive ability of assisted reproductive technology (ART)-conceived adolescents. DESIGN: A nested case-control study within a historic cohort. SETTING: Not applicable. PATIENT(S): A total of 253 ART-conceived adolescents born between 1982 and 1993 and 253 matched references according to birth year, gender, and the high-school they attended. INTERVENTION(S): None...
January 5, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28077106/age-of-onset-of-substance-use-and-psychosocial-problems-among-individuals-with-substance-use-disorders
#19
Anju Poudel, Sital Gautam
BACKGROUND: Substance use is generally initiated in adolescence or early adulthood and is commonly associated with several physical, psychological, emotional and social problems. The objective of this study is to assess the age of onset of substance use differences on psychosocial problems among individuals with substance use disorders (SUDs) residing in drug rehabilitation centers. METHODS: A descriptive cross sectional research design was carried out. Probability Proportional to Size (PPS) sampling technique was used to select the drug rehabilitation centers and all the respondents meeting the inclusion criteria of the selected seven rehabilitation centers were taken as a sample and comprised of 221 diagnosed individuals with SUDs...
January 11, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28060693/quality-of-life-in-children-with-obsessive-compulsive-disorder
#20
REVIEW
Joana Vieira, Filipa Ramalho E Silva
INTRODUCTION: Obsessive-compulsive disorder is a psychiatric disorder stated as one of the most debilitating diseases in the developedworld. However, not much is known about how this disease impairs patients' quality of life in children. MATERIAL AND METHODS: We conducted a research in PubMed and Thomson Reuters Web Of Science using the following terms: 'Quality of life', 'Obsessive-compulsive disorder', 'Child', 'Pediatrics' and 'Adolescent'. Of the 138 papers retrieved with this search, five articles corresponded to the aim of this review...
September 2016: Acta Médica Portuguesa
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