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https://www.readbyqxmd.com/read/28936540/-chondral-and-osteochondral-defects-representation-by-imaging-methods
#1
REVIEW
S Nebelung, B Rath, M Tingart, C Kuhl, S Schrading
Morphological imaging of cartilage at high resolution allows the differentiation of chondral and osteochondral lesions. Nowadays, magnetic resonance imaging is the principal diagnostic tool in the assessment of cartilage structure and composition. Conventional radiography, computed tomography, ultrasound or optical coherence tomography are adjunct diagnostic modalities in the assessment of cartilage pathologies. The present article discusses the up-to-date diagnostic practice of cartilage imaging in terms of its scientific basis and current clinical status, requirements, techniques and image interpretation...
September 21, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28934879/two-year-evaluation-of-osteochondral-repair-with-a-novel-biphasic-graft-saturated-in-bone-marrow-in-an-equine-model
#2
Taralyn M McCarrel, Sarah L Pownder, Susannah Gilbert, Matthew F Koff, Emme Castiglione, Ryan A Saska, Gino Bradica, Lisa A Fortier
Objective To evaluate a biphasic cartilage repair device (CRD) for feasibility of arthroscopic implantation, safety, biocompatibility, and efficacy for long-term repair of large osteochondral defects. Methods The CRD was press-fit into defects (10 mm diameter, 10 mm deep) created in the femoral trochlea of 12 horses. In the contralateral limb, 10 mm diameter full-thickness chondral defects were treated with microfracture (MFX). Radiographs were obtained pre- and postoperatively, and at 4, 12, and 24 months...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934875/natural-type-ii-collagen-hydrogel-fibrin-sealant-and-adipose-derived-stem-cells-as-a-promising-combination-for-articular-cartilage-repair
#3
Mariana Lazarini, Pedro Bordeaux-Rego, Renata Giardini-Rosa, Adriana S S Duarte, Mariana Ozello Baratti, Alessandro Rozim Zorzi, João Batista de Miranda, Carlos Lenz Cesar, Ângela Luzo, Sara Teresinha Olalla Saad
Objective Articular cartilage is an avascular tissue with limited ability of self-regeneration and the current clinical treatments have restricted capacity to restore damages induced by trauma or diseases. Therefore, new techniques are being tested for cartilage repair, using scaffolds and/or stem cells. Although type II collagen hydrogel, fibrin sealant, and adipose-derived stem cells (ASCs) represent suitable alternatives for cartilage formation, their combination has not yet been investigated in vivo for focal articular cartilage defects...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28919498/accelerated-return-to-sport-after-acl-reconstruction-and-early-knee-osteoarthritis-features-at-1-year-an-exploratory-study
#4
Adam G Culvenor, Brooke E Patterson, Ali Guermazi, Hayden G Morris, Timothy S Whitehead, Kay M Crossley
BACKGROUND: A timely return to competitive sport is a primary goal of anterior cruciate ligament reconstruction (ACLR). It is not known if an accelerated return-to-sport increases the risk of early-onset knee osteoarthritis (KOA). OBJECTIVE: To determine whether an accelerated return-to-sport post-ACLR (i.e., <10 months) is associated with increased odds of early KOA features on MRI 1-year post-surgery, and to evaluate the relationship between an accelerated return-to-sport and early KOA features stratified by type of ACL injury (isolated or concurrent chondral/meniscal injury) and lower-limb function (good or poor)...
September 14, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28915523/-biologic-reconstruction-of-full-sized-cartilage-defects-of-the-hip-a-guideline-from-the-dgou-group-clinical-tissue-regeneration-and-the-hip-committee-of-the-aga
#5
Stefan Fickert, Matthias Aurich, Dirk Albrecht, Peter Angele, Lorenz Büchler, Michael Dienst, Christoph Erggelet, Jürgen Fritz, Christoph Gebhart, Hans Gollwitzer, Moritz Kindler, Christoph Lampert, Henning Madry, Gregor Möckel, Phillip Niemeyer, Jörg Schröder, Christian Sobau, Gunter Spahn, Wolfgang Zinser, Stefan Landgraeber
Background Symptomatic pre-arthritic deformities such as femoroacetabular impingement (FAI) or hip dysplasia often lead to localised cartilage defects and subsequently to osteoarthritis. The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) and the hip committee of the AGA (German speaking Society for Arthroscopy and Joint Surgery) provides an overview of current knowledge of the diagnosis and surgical treatment of cartilage defects, in order to infer appropriate therapy recommendations for the hip...
September 15, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28914334/the-clinical-and-radiological-results-of-individualized-surgical-treatment-depending-on-pathologic-abnormalities-in-recurrent-patellar-dislocation-low-recurrence-rate-but-unintended-patella-baja
#6
Do Kyung Lee, Joon Ho Wang, Seung Hoon Kang, Jun Ho Kim, Russel Haque, Byung Hoon Lee
PURPOSE: To evaluate the clinical and radiological outcomes and chondral lesion change using individualized surgery for recurrent patellar dislocation. METHODS: A total of 31 knees with recurrent patellar dislocation underwent surgery depending on individual pathologic abnormalities. Pathologic abnormalities including medial laxity, lateral tightness, increased tibial tuberosity (TT)-to-trochlear groove distance (>20 mm), and patella alta (Caton-Deschamps ratio >1...
September 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28913600/a-multilayer-biomaterial-for-osteochondral-regeneration-shows-superiority-vs-microfractures-for-the-treatment-of-osteochondral-lesions-in-a-multicentre-randomized-trial-at-2-years
#7
Elizaveta Kon, Giuseppe Filardo, Mats Brittberg, Maurizio Busacca, Vincenzo Condello, Lars Engebretsen, Stefan Marlovits, Philipp Niemeyer, Patrik Platzer, Michael Posthumus, Peter Verdonk, Renè Verdonk, Jan Victor, Willem van der Merwe, Wojciech Widuchowski, Claudio Zorzi, Maurilio Marcacci
PURPOSE: The increasing awareness on the role of subchondral bone in the etiopathology of articular surface lesions led to the development of osteochondral scaffolds. While safety and promising results have been suggested, there are no trials proving the real potential of the osteochondral regenerative approach. Aim was to assess the benefit provided by a nanostructured collagen-hydroxyapatite (coll-HA) multilayer scaffold for the treatment of chondral and osteochondral knee lesions. METHODS: In this multicentre randomized controlled clinical trial, 100 patients affected by symptomatic chondral and osteochondral lesions were treated and evaluated for up to 2 years (51 study group and 49 control group)...
September 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28910133/a-comparison-of-2-year-outcomes-in-patients-undergoing-tibiofemoral-or-patellofemoral-matrix-induced-autologous-chondrocyte-implantation
#8
Jay R Ebert, Adrian Schneider, Michael Fallon, David J Wood, Gregory C Janes
BACKGROUND: Matrix-induced autologous chondrocyte implantation (MACI) has demonstrated encouraging clinical results in the treatment of knee chondral defects. However, earlier studies suggested that chondrocyte implantation in the patellofemoral (PF) joint was less effective than in the tibiofemoral (TF) joint. PURPOSE: To compare the radiological and clinical outcomes of those undergoing MACI to either the femoral condyles or PF joint. STUDY DESIGN: Cohort study; Level of evidence, 3...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28894878/erratum-to-one-step-surgery-with-multipotent-stem-cells-and-hyaluronan-based-scaffold-for-the-treatment-of-full-thickness-chondral-defects-of-the-knee-in-patients-older-than-45%C3%A2-years
#9
Alberto Gobbi, Celeste Scotti, Georgios Karnatzikos, Abhishek Mudhigere, Marc Castro, Giuseppe M Peretti
No abstract text is available yet for this article.
September 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28892654/single-stage-cartilage-repair-using-platelet-rich-fibrin-scaffolds-with-autologous-cartilaginous-grafts
#10
Chin-Chean Wong, Chih-Hwa Chen, Wing P Chan, Li-Hsuan Chiu, Wei-Pin Ho, Fon-Jou Hsieh, You-Tzung Chen, Tsung-Lin Yang
BACKGROUND: To avoid complicated procedures requiring in vitro chondrocyte expansion for cartilage repair, the development of a culture-free, 1-stage approach combining platelet-rich fibrin (PRF) and autologous cartilage grafts may be the solution. PURPOSE: To develop a feasible 1-step procedure to combine PRF and autologous cartilage grafts for articular chondral defects. STUDY DESIGN: Controlled laboratory study Methods: The chemotactic effects of PRF on chondrocytes harvested from the primary culture of rabbit cartilage were evaluated in vitro and ex vivo...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28875272/lars%C3%A2-in-acl-reconstruction-evaluation-of-60-cases-with-5-year-minimum-follow-up
#11
G Bugelli, G Dell'Osso, F Ascione, E Gori, V Bottai, S Giannotti
PURPOSE: The injury of anterior cruciate ligament (ACL) causes joint instability and, in the absence of adequate treatment, progressive joint deterioration, meniscal lesions and development of post-traumatic osteoarthritis. METHODS: The purpose of this study was to evaluate the clinical, functional and radiographic outcomes and complications in a consecutive case series of 60 patients with minimum follow-up of 5 years who underwent an arthroscopic surgery for ACL reconstruction using LARS™ ligament...
September 5, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28874815/injectable-and-thermosensitive-tgf-%C3%AE-1-loaded-pcec-hydrogel-system-for-in-vivo-cartilage-repair
#12
Tengfei Zhou, Xiaolong Li, Guo Li, Taoran Tian, Shiyu Lin, Sirong Shi, Jinfeng Liao, Xiaoxiao Cai, Yunfeng Lin
Chondral defects pose a great challenge for clinicians to manage owing to the limited capacity for self-healing. Various traditional approaches have been adopted for the repair of these defects with unsatisfactory results. Cartilage tissue engineering techniques have emerged as promising strategies to enhance regeneration and overcome these traditional shortcomings. The cell-homing based technique is considered the most promising owing to its unique advantages. Thermosensitive hydrogels have been applied as scaffolds for biomedical applications with smart sol-gel response for altering environmental temperature...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28872895/hyaluronic-acid-accelerates-tendon-to-bone-healing-after-rotator-cuff-repair
#13
Hirokazu Honda, Masafumi Gotoh, Tomonoshin Kanazawa, Hiroki Ohzono, Hidehiro Nakamura, Keisuke Ohta, Kei-Ichiro Nakamura, Kanji Fukuda, Takeshi Teramura, Takashi Hashimoto, Shigeki Shichijo, Naoto Shiba
BACKGROUND: There is growing evidence that the subacromial injection of hyaluronic acid (HA) is effective for pain relief in rotator cuff tears; however, its effect on tendon-to-bone healing remains unknown. PURPOSE: To examine the effect of HA on the chondrogenesis of mesenchymal stem cells (MSCs) in vitro and on tendon-to-bone healing in a rotator cuff repair model. STUDY DESIGN: Controlled laboratory study. METHODS: Bilateral complete tears of the infraspinatus tendon were made in rabbits and subsequently repaired...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28868322/viability-and-tissue-quality-of-cartilage-flaps-from-patients-with-femoroacetabular-hip-impingement-a-matched-control-comparison
#14
Francisco Rodriguez-Fontan, Karin A Payne, Jorge Chahla, Omer Mei-Dan, Abigail Richards, Soshi Uchida, Cecilia Pascual-Garrido
BACKGROUND: Chondrolabral damage is commonly observed in patients with cam-type femoroacetabular impingement (FAI). Chondral flap reattachment has recently been proposed as a possible preservation technique. PURPOSE/HYPOTHESIS: The purpose of this study was to determine the viability and tissue quality of chondral flaps from patients with FAI at the time of arthroscopy. It was hypothesized that chondral flaps from patients with cam lesions of the hip would exhibit less viability and greater tissue degeneration than would those of a matched control group...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28868088/chondral-defects-of-the-glenohumeral-joint-long-term-outcome-after-microfracturing-of-the-shoulder
#15
Sophia M Hünnebeck, Petra Magosch, Peter Habermeyer, Markus Loew, Sven Lichtenberg
INTRODUCTION: An increasing number of young patients are diagnosed with chondral lesions. Minimally invasive surgical techniques are important in order to delay progression of the early stages of osteoarthritis and the need for total joint replacement. MATERIALS AND METHODS: Patients (n = 32) who had received microfracturing of the shoulder were retrospectively enrolled, of whom 5 had received shoulder replacements after a mean time of 47 months. Of these patients, 23 completed the Disabilities of the Arm, Shoulder and Hand (DASH) and Constant-Murley Scores in addition to an additional subjective questionnaire...
2017: Obere Extremität
https://www.readbyqxmd.com/read/28867053/osteochondral-autograft-and-allograft-transplantation-in-the-talus
#16
REVIEW
Alan Ng, Kaitlyn Bernhard
Large, symptomatic, focal chondral, and osteochondral lesions of the ankle are treated with osteochondral autograft/allograft transplantation (OAT) procedure, a reconstructive bone grafting technique that uses one or more cylindrical osteochondral grafts from an area of low impact or allograft source and transplants them into the prepared defect site on the talus. This technique allows defects to be filled with mature, hyaline articular cartilage. Acute or chronic chondral or osteochondral lesions can be debilitating; provided here is a review of osteochondral autograft or allograft transplantation...
October 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28865590/matrix-associated-stem-cell-transplantation-mast-in-chondral-defects-of-the-1st-metatarsophalangeal-joint-is-safe-and-effective-2-year-follow-up-in-20-patients
#17
Martinus Richter, Stefan Zech, Stefan Andreas Meissner
The aim of the study was to assess the 2-year-follow-up of matrix-associated stem cell transplantation (MAST) in chondral defects of the 1st metatarsophalangeal joint (MTPJ). In a prospective consecutive non-controlled clinical follow-up study, 20 patients with 25 chondral defect at the 1st MTPJ that were treated with MAST from October 1st, 2011 to March, 30th, 2013 were analysed. The size and location of the chondral defects range of motion (ROM), and the Visual-Analogue-Scale Foot and Ankle (VAS FA) before treatment and at follow-up were registered...
September 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28864934/gene-therapy-for-chondral-and-osteochondral-regeneration-is-the-future-now
#18
REVIEW
Daniele Bellavia, F Veronesi, V Carina, V Costa, L Raimondi, A De Luca, R Alessandro, M Fini, G Giavaresi
Gene therapy might represent a promising strategy for chondral and osteochondral defects repair by balancing the management of temporary joint mechanical incompetence with altered metabolic and inflammatory homeostasis. This review analysed preclinical and clinical studies on gene therapy for the repair of articular cartilage defects performed over the last 10 years, focussing on expression vectors (non-viral and viral), type of genes delivered and gene therapy procedures (direct or indirect). Plasmids (non-viral expression vectors) and adenovirus (viral vectors) were the most employed vectors in preclinical studies...
September 1, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28861126/soft-tissue-based-surgical-techniques-for-treatment-of-posterior-shoulder-instability
#19
REVIEW
Alessandro Castagna, Marco Conti, Raffaele Garofalo
Posterior shoulder instability is a rare clinical condition that encompasses different degrees of severity including various possible pathologies involving the labrum, capsule, bony lesions, and even locked posterior dislocation. When focusing on soft tissue involvement, the diagnosis of posterior instability may be difficult to make because frequently patients report vague symptoms not associated with a clear history of traumatic shoulder dislocation. Pathological soft tissue conditions associated with posterior instability in most cases are related to posterior labral tear and/or posterior capsular detensioning/tear...
2017: Obere Extremität
https://www.readbyqxmd.com/read/28857138/biallelic-mutations-in-dync2li1-are-a-rare-cause-of-ellis-van-creveld-syndrome
#20
Marcello Niceta, Katia Margiotti, Maria Cristina Digilio, Valentina Guida, Alessandro Bruselles, Simone Pizzi, Alessandro Ferraris, Luigi Memo, Nicola Laforgia, Maria Lisa Dentici, Federica Consoli, Isabella Torrente, Victor L Ruiz-Perez, Bruno Dallapiccola, Bruno Marino, Alessandro De Luca, Marco Tartaglia
Ellis van Creveld syndrome (EvC) is a chondral and ectodermal dysplasia caused by biallelic mutations in the EVC, EVC2 and WDR35 genes. A proportion of cases with clinical diagnosis of EvC, however, do not carry mutations in these genes. To identify the genetic cause of EvC in a cohort of mutation-negative patients, exome sequencing was undertaken in a family with three affected members, and mutation scanning of a panel of clinically and functionally relevant genes was performed in 24 additional subjects with features fitting/overlapping EvC...
August 30, 2017: Clinical Genetics
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