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https://www.readbyqxmd.com/read/28637481/arthroscopic-treatment-of-focal-osteochondral-lesions-of-the-first-metatarsophalangeal-joint
#1
Ersin Kuyucu, Harun Mutlu, Serhat Mutlu, Baris Gülenç, Mehmet Erdil
BACKGROUND: Although arthroscopic surgical treatment of the first metatarsophalangeal (MTP) joint involves painful sesamoid excision, synovectomy, debridement, and partial cheilectomy, no gold standard treatment technique has been defined in the literature for hallux rigidus and focal osteochondral lesions. This study aimed to assess the arthroscopic treatment for early-grade focal osteochondral lesions of the first MTP joint and to determine the impact of arthroscopic microhole drill surgery on foot function and activities of daily living in a group of patients who failed conservative treatment...
June 21, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28635368/efficacy-and-safety-of-autologous-cell-therapies-for-knee-cartilage-defects-autologous-stem-cells-chondrocytes-or-the-two-randomized-controlled-trial-design
#2
James B Richardson, Karina T Wright, Johanna Wales, Jan Herman Kuiper, Helen S McCarthy, Peter Gallacher, Paul E Harrison, Sally Roberts
AIM: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. PATIENTS & METHODS: Patients with symptomatic chondral/osteochondral defects will be randomized to cell therapy treatment with one of three cell populations (1:1:1). The primary efficacy outcome is a functional knee score (Lysholm) at 15 months post-treatment and the primary safety outcome is the incidence of adverse events...
June 21, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28632455/joint-preservation-techniques-in-orthopaedic-surgery
#3
Philip J York, Frank B Wydra, Matthew E Belton, Armando F Vidal
CONTEXT: With increasing life expectancy, there is growing demand for preservation of native articular cartilage to delay joint arthroplasties, especially in younger, active patients. Damage to the hyaline cartilage of a joint has a limited intrinsic capacity to heal. This can lead to accelerated degeneration of the joint and early-onset osteoarthritis. Treatment in the past was limited, however, and surgical treatment options continue to evolve that may allow restoration of the natural biology of the articular cartilage...
June 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28631112/risk-of-revision-was-not-reduced-by-a-double-bundle-acl-reconstruction-technique-results-from-the-scandinavian-registers
#4
Cathrine Aga, Jüri-Tomas Kartus, Martin Lind, Stein Håkon Låstad Lygre, Lars-Petter Granan, Lars Engebretsen
BACKGROUND: Double-bundle anterior cruciate ligament (ACL) reconstruction has demonstrated improved biomechanical properties and moderately better objective outcomes compared with single-bundle reconstructions. This could make an impact on the rerupture rate and reduce the risk of revisions in patients undergoing double-bundle ACL reconstruction compared with patients reconstructed with a traditional single-bundle technique. The National Knee Ligament Registers in Scandinavia provide information that can be used to evaluate the revision outcome after ACL reconstructions...
June 19, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28630725/endoscopic-repair-of-hip-abductor-tears-outcomes-with-two-year-follow-up
#5
J W Thomas Byrd, Kay S Jones
Abductor lesions are increasingly recognized as a source of recalcitrant laterally based hip pain and dysfunction. There is a growing body of evidence that many of these may be amenable to endoscopic repair. To report the demographic data and outcomes of endoscopic hip abductor repair. Twelve patients underwent endoscopic abductor repair with 2-year follow-up. These patients were prospectively assessed with modified Harris hip and iHOT scores. The indications for surgery were clinical and MRI findings of symptomatic abductor tears that had failed conservative treatment...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28627226/light-absorptive-properties-of-articular-cartilage-ecm-molecules-synovial-fluid-and-photoinitiators-as-potential-barriers-to-light-initiated-polymer-scaffolding-procedures
#6
Anthony J Finch, Jamie M Benson, Patrick E Donnelly, Peter A Torzilli
Objective Many in vivo procedures to repair chondral defects use ultraviolet (UV)-photoinitiated in situ polymerization within the cartilage matrix. Chemical species that absorb UV light might reduce the effectiveness of these procedures by acting as light absorption barriers. This study evaluated whether any of the individual native biochemical components in cartilage and synovial fluid interfered with the absorption of light by common scaffolding photosensitizers. Materials UV-visible spectroscopy was performed on each major component of cartilage in solution, on bovine synovial fluid, and on four photosensitizers, riboflavin, Irgacure 2959, quinine, and riboflavin-5'-phosphate...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28624853/biophysical-stimulation-improves-clinical-results-of-matrix-assisted-autologous-chondrocyte-implantation-in-the-treatment-of-chondral-lesions-of-the-knee
#7
Marco Collarile, Andrea Sambri, Giada Lullini, Matteo Cadossi, Claudio Zorzi
PURPOSE: The purpose of the present study was to evaluate the effects of pulsed electromagnetic fields (PEMFs) on clinical outcome in patients who underwent arthroscopic matrix-assisted autologous chondrocyte implantation (MACI) for chondral lesions of the knee. METHODS: Thirty patients affected by grade III and IV International Cartilage Repair Society chondral lesions of the knee underwent MACI. After surgery, patients were randomly assigned to either experimental group (PEMFs 4 h per day for 60 days) or control group ...
June 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28622807/the-comparison-of-the-effects-of-a-novel-hydrogel-compound-and-traditional-hyaluronate-following-micro-fracture-procedure-in-a-rat-full-thickness-chondral-defect-model
#8
Yunus Emre Akman, Erhan Sukur, Ahmet Senel, Nur Ece Oztas Sukur, Canan Kelten Talu, Yusuf Ozturkmen
PURPOSE: The aim of this experimental study was to investigate the impact of HA-CS-NAG compound (hyaluronate, sodium chondroitin sulfate, N-acetyl-d-glucosamine) on the quality of repair tissue after micro-fracture and to compare it with HA (hyaluronat), in a rat full-thickness chondral defect model. METHODS: Full-thickness chondral defects were created in a non-weight bearing area by using a handle 2.7-mm drill bit, in the right knees of 33 Sprague-Dawley rats...
June 13, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28618872/outcomes-of-patellofemoral-osteochondral-lesions-treated-with-structural-grafts-in-patients-older-than-40-years
#9
Ryan M Degen, Nathan W Coleman, Danielle Tetreault, Brenda Chang, Greg T Mahony, Christopher L Camp, Shawn G Anthony, Riley J Williams
Background Chondral lesions in the patellofemoral compartment represent a difficult entity to treat among active patients, with no clear consensus on the optimal treatment strategy. The purpose of this study was to review the functional outcomes of patients >40 years old with primary patellofemoral osteochondral lesions who underwent a cartilage restoration procedure with a structural graft. Methods Following institutional review board approval, 35 patients >40 years treated for patellofemoral chondral or osteochondral injuries were retrospectively identified...
July 2017: Cartilage
https://www.readbyqxmd.com/read/28616703/preparation-of-a-biphase-composite-scaffold-and-its-application-in-tissue-engineering-for-femoral-osteochondral-defects-in-rabbits
#10
Shi-Qiang Ruan, Ling Yan, Jiang Deng, Wen-Liang Huang, Dian-Ming Jiang
PURPOSE: Three-dimensional bioactive scaffolds are useful tools for stem cell implant in tissue-engineering. For chondral and subchondral repair, the chondroinductive and osteoinductive property of a scaffold is a major challenge. The scaffolds that aim to osteogenic differentiation have been well studied. However, cartilage cells can hardly be induced for osteogenesis, and monophase scaffolds cannot ideally repair both cartilage and subchondral defects at the same time. METHODS: We developed a novel biphase composite scaffold and observe its application osteochondral defects...
June 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28612705/treatment-of-acetabular-chondral-lesions-with-microfracture-technique
#11
Claudio Mella, Alvaro Nuñez, Ignacio Villalón
INTRODUCTION: Acetabular cartilage lesions are frequently found during hip arthroscopy. In the hip joint they mostly occur secondary to a mechanical overload resulting from a pre-existing deformity as hip dysplasia or femoroacetabular impingement (FAI). Lesions identified during arthroscopy can vary greatly from the earliest stages to the most advanced (full-thickness lesions). These lesions occur in the acetabulum in the early stages of joint damage. Microfractures are indicated in full-thickness chondral defects...
2017: SICOT-J
https://www.readbyqxmd.com/read/28608754/a-preliminary-study-comparing-microfracture-and-local-adherent-transplantation-of-autologous-adipose-derived-stem-cells-followed-by-intraarticular-injection-of-platelet-rich-plasma-for-the-treatment-of-chondral-defects-in-rabbits
#12
Timea Spakova, Judita Amrichova, Jana Plsikova, Denisa Harvanova, Slavomir Hornak, Valent Ledecky, Jan Rosocha
Objective This study aimed to compare microfracture and application of adipose-derived stem cells (ADSCs) by local adherent technique enhanced by platelet-rich plasma (PRP) to provide a new approach for the repair of cartilage defect. Design Full-thickness cylindrical defects were created in the medial femoral condyle in 9 New Zealand White rabbits (5 months old, 4.65 ± 0.20 kg). Two groups of rabbits ( n = 3) were either treated with ADSCs (Group 1) or the microfracture technique (Group 2) following intraarticular injection of PRP 3 times in weekly intervals...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28607559/bone-marrow-aspirate-concentrate-enhanced-marrow-stimulation-of-chondral-defects
#13
REVIEW
Henning Madry, Liang Gao, Hermann Eichler, Patrick Orth, Magali Cucchiarini
Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. The additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation is thought to enhance cartilage repair as it may provide both an additional cell population capable of chondrogenesis and a source of growth factors stimulating cartilage repair...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28605000/hip-arthroscopy-in-patients-less-than-25-years-of-age-in-the-treatment-of-labral-tears-aetiology-and-clinical-outcomes
#14
Gillian Bayley, Stephane Poitras, Gillian Parker, Paul E Beaulé
BACKGROUND: Hip arthroscopy has evolved into a well-established and rapidly growing field of orthopedic surgery for the management of labral tears. The purpose of this study was to review clinical outcomes of patients less than 25 years of age undergoing hip arthroscopy for treatment of a labral tear. METHODS: From 2005 to 2013, 82 hips in 76 patients with mean age of 20.4 (16-25 range) underwent hip arthroscopy for treatment of labral-chondral damage. The Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and hip disability and osteoarthritis outcome score (HOOS) were recorded at latest follow-up...
June 7, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28604062/cartilage-regeneration-in-full-thickness-patellar-chondral-defects-treated-with-particulated-juvenile-articular-allograft-cartilage-an-mri-analysis
#15
Brian Grawe, Alissa Burge, Joseph Nguyen, Sabrina Strickland, Russell Warren, Scott Rodeo, Beth ShubinStein
Background Full-thickness cartilage lesions of the patella represent a common source of pain and dysfunction. Previously reported surgical treatment options include marrow stimulation, cell-based treatments, and osteochondral transfer. Minced juvenile allograft cartilage is a novel treatment option that allows for a single stage approach for these lesions. Hypothesis Particulated juvenile allograft cartilage (PJAC) for the treatment of chondral defects of the patella would offer acceptable lesion fill rates, mature over time, and not be associated with any negative biologic effects on the surrounding tissue...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28603570/successful-treatment-of-painful-synchondrosis-of-bipartite-patella-after-direct-trauma-by-operative-fixation-a-series-of-six-cases
#16
Sarkhell Radha, Michael Shenouda, Sujith Konan, Jonathon Lavelle, Samuel Church
INTRODUCTION: The patella is the largest sesamoid bone in the body and may have one (77%) or multiple (23%) ossification centres. Patellar and patellofemoral joint abnormalities are a common cause of anterior knee pain but symptomatic bipartite patella is an uncommon problem. CASE SERIES: We report a series of six cases of painful synchondrosis in bipartite patellae, all in keen athletes following a direct blow to the anterior aspect of the knee. A complete rupture of the synchondrosis with evidence of retropatellar chondral separation was seen on MRI scan in all cases...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28601393/oxidized-zirconium-versus-cobalt-chromium-against-the-native-patella-in-total-knee-arthroplasty-patellofemoral-outcomes
#17
Fabrizio Matassi, Tommaso Paoli, Roberto Civinini, Christian Carulli, Massimo Innocenti
BACKGROUND: Oxidized zirconium (OxZr) has demonstrated excellent mechanical properties in vitro when used against articular cartilage; less coefficient of friction and less chondral damage have been found when compared with cobalt-chromium (CoCr) implants. However, controversy exists as to whether implants with a zirconium femoral component articulate safely with a native patella in total knee arthroplasty (TKA). To answer this question, the clinical and radiographic results were analysed from a group of patients who underwent a TKA with patella retention; the OxZr versus CoCr femoral components were compared...
June 7, 2017: Knee
https://www.readbyqxmd.com/read/28597240/mr-arthrography-of-the-hip-evaluation-of-isotropic-3d-intermediate-weighted-fse-and-hybrid-gre-t1-weighted-sequences
#18
Giovanni Foti, Antonio Campacci, Michele Conati, Mirko Trentadue, Claudio Zorzi, Giovanni Carbognin
PURPOSE: To compare the diagnostic performance of three-dimensional (3D) intermediate-weighted FSE (IW-3D) and 3D hybrid T1-weighted sequences (Hy-3D) and 2D fast-spin-echo sequences (FSE) in diagnosing chondral and labral lesions at 1.5 Tesla hip MR arthrography (MRA). MATERIALS AND METHODS: Institutional review board approval was obtained and informed consent was waived. Ninety-two consecutive patients were evaluated. Chondral and labral lesions were retrospectively and independently evaluated by two radiologists...
June 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28594526/the-four-most-common-types-of-knee-cartilage-damage-encountered-in-practice-how-and-why-orthopaedic-surgeons-manage-them
#19
Brian J Chilelli, Brian J Cole, Jack Farr, Christian Lattermann, Andreas H Gomoll
Cartilage damage of the knee is common and may present in patients as a variety of symptoms. These conditions can be classified based on location, etiology, and/or pathophysiology. A systematic approach to the evaluation and classification of chondral injuries helps improve definitive management. The four most common types of knee cartilage damage are osteochondritis dissecans, incidental chondral defects, patellofemoral defects, and defects encountered after meniscectomy.
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594522/skeletally-immature-anterior-cruciate-ligament-injuries-controversies-and-management
#20
Shital N Parikh, Bradley P Jaquith, Christopher M Brusalis, Lauren H Redler, Theodore J Ganley, Mininder S Kocher
At one time, anterior cruciate ligament (ACL) tears in skeletally immature patients were considered rare. The recommended treatment option for skeletally immature patients with ACL tears was to modify activities until skeletal maturity, at which point definitive ACL reconstruction could be safely performed. The management of ACL tears in skeletally immature patients has evolved as a result of the increased frequency of ACL tears in younger patients and an increased awareness for the potential development or worsening of meniscal tears, chondral lesions, and degenerative changes that occur with the "wait-and-fix-later" approach...
February 15, 2017: Instructional Course Lectures
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