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https://www.readbyqxmd.com/read/28075154/survivorship-after-meniscal-allograft-transplantation-according-to-articular-cartilage-status
#1
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Won-Kyeong Kim, Jun Weon Choi
BACKGROUND: Clinical outcomes after meniscal allograft transplantation (MAT) in arthritic knees are unclear, and objective estimates of graft survival according to the articular cartilage status have not been performed. HYPOTHESIS: MAT should provide clinical benefits in knees with high-grade cartilage damage, but their graft survivorship should be inferior to that in knees with low-grade chondral degeneration after MAT. STUDY DESIGN: Cohort study; Level of evidence, 3...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28073305/human-amniotic-mesenchymal-stromal-cells-as-favourable-source-for-cartilage-repair
#2
Emma Muinos-López, Tamara Hermida-Gómez, Isaac Fuentes-Boquete, Francisco Javier de Toro-Santos, Francisco J Blanco, Silvia María Díaz-Prado
INTRODUCTION: Localized trauma-derived breakdown of the hyaline articular cartilage may progress towards osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint function. Tissue engineering technologies encompass several promising approaches with high therapeutic potential for the treatment of these focal defects. However, most of the research in tissue engineering is focused on potential materials and structural cues, while little attention is directed to the most appropriate source of cells endowing these materials...
January 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28072472/sonographic-findings-of-chondral-avulsion-fractures-of-the-lateral-ankle-ligaments-in-children
#3
Manabu Maeda, Nana Maeda, Takanori Takaoka, Yasuhito Tanaka
In this series, we aimed to describe the sonographic findings of chondral avulsion fractures that develop concomitant with lateral ankle ligament injury in children. We performed stress sonography during a manual anterior drawer stress procedure of the ankle in 9 skeletally immature patients who had recently had a lateral ankle sprain. Echo videos were obtained through the course of treatment, and all videos were reviewed. We elucidated the common features of chondral avulsion fractures of the lateral ankle ligaments in the children...
January 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28066742/autologous-membrane-induced-chondrogenesis-amic-for-the-treatment-of-acetabular-chondral-defect
#4
Andrea Fontana
BACKGROUND: Acetabular chondral defect are very frequently associated to FAI. Treatment options are still questionable. METHODS: Between 2008 and 2014, 201 patients over 583 have been arthroscopically treated with the AMIC procedure for grade III and/or IV acetabular chondral lesions. Patients age was between 18 and 50 years; acetabular chondral lesion size was between 2 and 4 cm(2); radiological Tönnis degree of osteoarthritis was ≤ 2. RESULTS: The mean follow up of the entire group of 201 patients was 5 years (from 8 to 2)...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28066741/cell-therapy-for-cartilage-defects-of-the-hip
#5
Rodrigo Mardones, Alessio Giai Via, Claudio Jofré, José Minguell, Claudio Rodriguez, Alexander Tomic, Matias Salineros
BACKGROUND: Chondral injuries are commonly related to poor clinical outcome, but recent data showed some improvements in function and pain after hip arthroscopy. Cell-based therapies represent an appealing alternative strategy for cartilage regeneration, and interesting results have been recently reported after intra-articular injections of mesenchymal stem cells (MSCs). The results of hip arthroscopy for femoroacetabular impingement (FAI) and intra-articular injections of autologous expanded bone marrow - MSCs (BM-MSCs) are reported in this retrospective study...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28056178/is-there-any-benefit-in-anterior-cruciate-ligament-reconstruction-in-patients-older-than-60-years
#6
Cécile Toanen, Guillaume Demey, Panagiotis G Ntagiopoulos, Paolo Ferrua, David Dejour
BACKGROUND: Results of anterior cruciate ligament (ACL) reconstruction are traditionally excellent in younger and nonarthritic patients. During the past few decades, people older than 60 years have become more active than ever, with more demanding physical lifestyles. An increase also has been noted in active patients with diagnosed ACL injuries. More patients are requesting treatment for ACL deficiency in hopes of returning to preinjury levels of activity. PURPOSE: The aims of this study were to evaluate the results of ACL reconstruction in patients older than 60 years in terms of functional recovery, return to sports, and postoperative incidence of osteoarthritis and to compare their results with published results of different age groups...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28054960/evaluation-of-magnetic-nanoparticle-labeled-chondrocytes-cultivated-on-a-type-ii-collagen-chitosan-poly-lactic-co-glycolic-acid-biphasic-scaffold
#7
Juin-Yih Su, Shi-Hui Chen, Yu-Pin Chen, Wei-Chuan Chen
Chondral or osteochondral defects are still controversial problems in orthopedics. Here, chondrocytes labeled with magnetic nanoparticles were cultivated on a biphasic, type II collagen-chitosan/poly(lactic-co-glycolic acid) scaffold in an attempt to develop cultures with trackable cells exhibiting growth, differentiation, and regeneration. Rabbit chondrocytes were labeled with magnetic nanoparticles and characterized by scanning electron microscopy (SEM), transmission electron (TEM) microscopy, and gene and protein expression analyses...
January 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28045867/failure-of-bone-marrow-stimulation-techniques
#8
Rachel M Frank, Eric J Cotter, Islam Nassar, Brian Cole
Marrow stimulation techniques, including microfracture, are among the most commonly performed cartilage restoration procedures for symptomatic chondral defects of the knee. For the vast majority of patients, marrow stimulation results in reduced pain and improved function, providing overall satisfactory outcomes. In some cases, however, marrow stimulation fails, resulting in symptom recurrence and often, the need for repeat surgery. This review will describe the indications and outcomes of microfracture as a primary surgical treatment for focal chondral defects of the knee, identify patient and procedure-specific factors associated with poor clinical outcomes, and will discuss treatment options and their respective outcomes for patients with a failed prior microfracture surgery...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28041611/the-mechanics-of-focal-chondral-defects-in-the-hip
#9
Brenden J Klennert, Benjamin J Ellis, Travis G Maak, Ashley L Kapron, Jeffrey A Weiss
There is a mean incidence of osteoarthritis (OA) of the hip in 8% of the overall population. In the presence of focal chondral defects, defined as localized damage to the articular cartilage, there is an increased risk of symptomatic progression toward OA. This relationship between chondral defects and subsequent development of OA has led to substantial efforts to develop effective procedures for surgical cartilage repair. This study examined the effects of chondral defects and labral delamination on cartilage mechanics in the dysplastic hip during the gait cycle using subject-specific finite element analysis...
November 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28040117/skeletal-dysplasia-with-bowing-long-bones-proposed-flowchart-for-prenatal-diagnosis-with-case-demonstration
#10
Gabriele Tonni, Marcella Palmisano, Mario Lituania, Gianpaolo Grisolia, Ave Maria Baffico, Maria Paola Bonasoni, Pierpaolo Pattacini, Claudio De Felice, Edward Araujo Júnior
OBJECTIVE: Skeletal dysplasia with bowing long bones is a rare group of multiple characterized congenital anomalies. MATERIALS AND METHODS: We introduce a simple, practical diagnostic flowchart that may be helpful in identifying the appropriate pathway of obstetrical management. RESULTS: Herein, we describe four fetal cases of bent bony dysplasia that focus on ultrasound findings, phenotype, molecular tests, distinctive X-ray features, and chondral growth plate histology...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28040083/a-novel-aragonite-based-scaffold-for-osteochondral-regeneration-early-experience-on-human-implants-and-technical-developments
#11
Elizaveta Kon, Dror Robinson, Peter Verdonk, Matej Drobnic, Jenel Mariano Patrascu, Oliver Dulic, Gordon Gavrilovic, Giuseppe Filardo
INTRODUCTION: Chondral and osteochondral lesions represent a debilitating disease. Untreated lesions remain a risk factor for more extensive joint damage. The objective of this clinical study is to evaluate safety and early results of an aragonite-based scaffold used for osteochondral unit repair, by analysing both clinical outcome and MRI results, as well as the benefits of the procedure optimization through novel tapered shaped implants. METHODS: A crystalline aragonite bi-phasic scaffold was implanted in patients affected by focal chondral-osteochondral knee lesions of the condyle and trochlea...
December 2016: Injury
https://www.readbyqxmd.com/read/28013325/intra-articular-pathologies-associated-with-chronic-ankle-instability
#12
Henryk Liszka, Paweł Depukat, Artur Gądek
Chronic ankle instability causes intra-articular lesions, which may lead to secondary degenerative changes. The aim of this study was to evaluate the usefulness of the ankle arthroscopy for the evaluation and treatment of intra-articular pathologies associated with chronic ankle instability. Between January 2013 and March 2016, 25 anterior ankle arthroscopies with modi ed anatomic Broström-Duquennoy-Tourne lateral ankle ligaments reconstructions were performed. In arthroscopy all patients (100%) had some intra-articular pathologies: 75% synovitis or so tissue scarring, 19% - deep chondral defect, 56% - superficial chondral lesion, 52% - osteophytes, 24% - bony or avulsion fragments, 20% - loose bodies...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28002905/arthroscopic-all-inside-treatment-of-popliteomeniscal-fascicles-tears-surgical-technique-and-results-from-the-first-6-consecutive-patients
#13
R Simonetta, G Di Vico, R Papalia, S Vasta, V Denaro
Athletes whose knees are subjected to sudden changes of direction and high jumps such as martial arts athletes, dancers, wrestlers and football players are at higher risk of injuring popliteomeniscal fascicles. Painful squatting and mechanical symptoms such as locking sensation are common. Current available treatments includes open or arthroscopic in repair. Arthroscopic repair with all-inside device can relieve symptoms and restore knee function. Six patients from two surgical centers with isolated popliteomeniscal fascicles tears were treated with arthroscopic all-inside repair...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27994721/particulated-juvenile-articular-cartilage-allograft-transplantation-for-osteochondral-talar-lesions
#14
Bryan M Saltzman, Johnny Lin, Simon Lee
OBJECTIVE: To report on our institution's early results from juvenile particulate cartilage allograft transplantation of the talus. DESIGN: Because of the relative rarity of the procedure at the talus, it was decided to provide a comprehensive understanding of the currently available evidence via a 2-part study with (1) a systematic review of the literature and (2) a retrospective single-center cohort study of the authors' patients, their demographics, and their early outcomes...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27993976/osteocrin-a-peptide-secreted-from-the-heart-and-other-tissues-contributes-to-cranial-osteogenesis-and-chondrogenesis-in-zebrafish
#15
Ayano Chiba, Haruko Watanabe-Takano, Kenta Terai, Hajime Fukui, Takahiro Miyazaki, Mami Uemura, Hisashi Hashimoto, Masahiko Hibi, Shigetomo Fukuhara, Naoki Mochizuki
The heart is an endocrine organ, because cardiomyocytes (CMs) secrete natriuretic peptide (NP) hormones. Since the discovery of NPs, no peptide hormones that affect remote organs have been identified from the heart. We identified osteocrine (Ostn) as an osteogenesis/chondrogenesis regulatory hormone secreted from CMs in zebrafish. The ostn mutant larvae exhibited impaired membranous and chondral bone formation. The impaired bones were recovered by CM-specific overexpression of Ostn. We analyzed parasphenoid (ps) as a representative of membranous bones...
December 19, 2016: Development
https://www.readbyqxmd.com/read/27990446/the-superior-regenerative-potential-of-muscle-derived-stem-cells-for-articular-cartilage-repair-is-attributed-to-high-cell-survival-and-chondrogenic-potential
#16
Hongshuai Li, Aiping Lu, Ying Tang, Sarah Beckman, Naoki Nakayama, Minakshi Poddar, MaCalus V Hogan, Johnny Huard
Three populations of muscle-derived cells (PP1, PP3, and PP6) were isolated from mouse skeletal muscle using modified preplate technique and retrovirally transduced with BMP4/GFP.  In vitro, the PP1 cells (fibroblasts) proliferated significantly slower than the PP3 (myoblasts) and PP6 cells (muscle-derived stem cells); the PP1 and PP6 cells showed a superior rate of survival compared with PP3 cells under oxidative stress; and the PP6 cells showed significantly superior chondrogenic capabilities than PP1 and PP3 cells...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27981785/morphological-study-ultrastructural-aspects-of-articular-cartilage-and-sub-chondral-bone-in-patients-affected-by-post-traumatic-shoulder-instability
#17
Paolo Baudi, Fabio Catani, Manuela Rebuzzi, Marzia Ferretti, Alberto Smargiassi, Gabriele Campochiaro, Fabio Serafini, Carla Palumbo
Post-traumatic shoulder instability is a frequent condition in active population, representing one of most disabling pathologies, due to altered balance involving joints. No data are so far available on early ultrastructural osteo-chondral damages, associated with the onset of invalidating pathologies, like osteoarthritis-OA. Biopsies of glenoid articular cartilage and sub-chondral bone were taken from 10 adult patients underwent arthroscopic stabilization. Observations were performed under Transmission Electron Microscopy-TEM in tangential, arcuate and radial layers of the articular cartilage and in the sub-chondral bone...
December 16, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27965140/multimodality-scoring-of-chondral-injuries-in-the-equine-fetlock-joint-ex%C3%A2-vivo
#18
J K Sarin, H Brommer, D Argüelles, P H Puhakka, S I Inkinen, I O Afara, S Saarakkala, J Töyräs
OBJECTIVE: We investigate the potential of a prototype multimodality arthroscope, combining ultrasound, optical coherence tomography (OCT) and arthroscopic indentation device, for assessing cartilage lesions, and compare the reliability of this approach with conventional arthroscopic scoring in equine joints ex vivo. DESIGN: Areas of interest (AIs, N = 43) were selected from equine fetlock joints (N = 5). Blind-coded AIs were independently scored by two equine surgeons employing International Cartilage Repair Society (ICRS) scoring system via conventional arthroscope and multimodality arthroscope, in which high-frequency ultrasound and OCT catheters were attached to an arthroscopic indentation device...
December 10, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27925639/outcomes-following-arthroscopic-repair-of-posterior-labral-tears-in-patients-older-than-35-years
#19
Dexter K Bateman, Eric M Black, Mark D Lazarus, Joseph A Abboud
Although the results of arthroscopic management of posterior labral pathology in young athletes have been reported extensively in the literature, the clinical outcomes in older patients are unknown. This retrospective review included patients older than 35 years who underwent arthroscopic posterior labral repair. Functional outcome scores were collected, and subgroup analyses were performed to evaluate the impact of patient-specific factors. Forty-three patients met the inclusion criteria; average follow-up was 36...
December 7, 2016: Orthopedics
https://www.readbyqxmd.com/read/27921206/periacetabular-osteotomy-provides-higher-survivorship-than-rim-trimming-for-acetabular-retroversion
#20
Corinne A Zurmühle, Helen Anwander, Christoph E Albers, Markus S Hanke, Simon D Steppacher, Klaus A Siebenrock, Moritz Tannast
BACKGROUND: Acetabular retroversion can cause impaction-type femoroacetabular impingement leading to hip pain and osteoarthritis. It can be treated by anteverting periacetabular osteotomy (PAO) or acetabular rim trimming with refixation of the labrum. There is increasing evidence that acetabular retroversion is a rotational abnormality of the entire hemipelvis and not a focal overgrowth of the anterior acetabular wall, which favors an anteverting PAO. However, it is unknown if this larger procedure would be beneficial in terms of survivorship and Merle d'Aubigné scores in a midterm followup compared with rim trimming...
December 5, 2016: Clinical Orthopaedics and related Research
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