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https://www.readbyqxmd.com/read/29688911/tranilast-blunts-the-hypertrophic-and-fibrotic-response-to-increased-afterload-independent-of-cardiomyocyte-transient-receptor-potential-vanilloid-2-channels
#1
Sheryl E Koch, Michelle L Nieman, Nathan Robbins, Samuel Slone, Mariah Worley, Lisa C Green, Yamei Chen, Alexandria Barlow, Michael Tranter, HongSheng Wang, John N Lorenz, Jack Rubinstein
Tranilast is clinically indicated for the treatment of allergic disorders and is also a non-selective blocker of the Transient Receptor Potential Vanilloid 2 (TRPV2) channel. Prior studies have found that it has protective effects in various animal models of cardiac disease. Our laboratory has found that genetic deletion of TRPV2 results in a blunted hypertrophic response to increased afterload, thus this study tested the hypothesis that tranilast through cardiomyocyte TRPV2 blockade can inhibit the hypertrophic response to pressure overload in-vivo via transverse aortic constriction and ex vivo via isolated myocyte studies...
April 20, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29668921/predictors-of-durability-of-radiological-response-in-patients-with-small-bowel-crohn-s-disease
#2
Parakkal Deepak, Joel G Fletcher, Jeff L Fidler, John M Barlow, Shannon P Sheedy, Amy B Kolbe, William S Harmsen, Terry Therneau, Stephanie L Hansel, Brenda D Becker, Edward V Loftus, David H Bruining
Background: The long-term significance of radiological transmural response (TR) as a treatment goal at the first follow-up scan in small bowel Crohn's disease (CD) has been previously shown. We examined the durability of a long-term strategy of treating to a target of radiological TR and the influence of baseline predictors on the maintenance of TR. Methods: Small bowel CD patients between January 1, 2002, and December 31, 2014, were identified with serial computed tomography enterography (CTE)/magnetic resonance enterography (MRE) before and after initiation of therapy or on maintenance therapy...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29625057/tumor-evolution-and-drug-response-in-patient-derived-organoid-models-of-bladder-cancer
#3
Suk Hyung Lee, Wenhuo Hu, Justin T Matulay, Mark V Silva, Tomasz B Owczarek, Kwanghee Kim, Chee Wai Chua, LaMont J Barlow, Cyriac Kandoth, Alanna B Williams, Sarah K Bergren, Eugene J Pietzak, Christopher B Anderson, Mitchell C Benson, Jonathan A Coleman, Barry S Taylor, Cory Abate-Shen, James M McKiernan, Hikmat Al-Ahmadie, David B Solit, Michael M Shen
Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human disease. Here, we describe a biobank of patient-derived organoid lines that recapitulates the histopathological and molecular diversity of human bladder cancer. Organoid lines can be established efficiently from patient biopsies acquired before and after disease recurrence and are interconvertible with orthotopic xenografts. Notably, organoid lines often retain parental tumor heterogeneity and exhibit a spectrum of genomic changes that are consistent with tumor evolution in culture...
April 5, 2018: Cell
https://www.readbyqxmd.com/read/29599518/psychological-outcomes-and-surgical-decisions-after-genetic-testing-in-women-newly-diagnosed-with-breast-cancer-with-and-without-a-family-history
#4
Bettina Meiser, Veronica F Quinn, Gillian Mitchell, Kathy Tucker, Kaaren J Watts, Belinda Rahman, Michelle Peate, Christobel Saunders, Elizabeth Geelhoed, Margaret Gleeson, Kristine Barlow-Stewart, Michael Field, Marion Harris, Yoland C Antill, Rachel Susman, Michael T Bowen, Llew Mills, Judy Kirk
In patients with early breast cancer, personal and tumour characteristics other than family history are increasingly used to prompt genetic testing to guide women's cancer management (treatment-focused genetic testing, 'TFGT'). Women without a known strong family history of breast and/or ovarian may be more vulnerable to psychological sequelae arising from TFGT. We compared the impact of TFGT in women with (FH+) and without (FH-) a strong family history on psychological adjustment and surgical decisions. Women aged <50 years with high-risk features were offered TFGT before definitive breast cancer surgery and completed self-report questionnaires at four time points over 12 months...
March 30, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29598857/the-impact-of-u-s-free-trade-agreements-on-calorie-availability-and-obesity-a-natural-experiment-in-canada
#5
Pepita Barlow, Martin McKee, David Stuckler
INTRODUCTION: Globalization via free trade and investment agreements is often implicated in the obesity pandemic. Concerns center on how free trade and investment agreements increase population exposure to unhealthy, high-calorie diets, but existing studies preclude causal conclusions. Few studies of free trade and investment agreements and diets isolated their impact from confounding changes, and none examined any effect on caloric intake, despite its critical role in the etiology of obesity...
March 14, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29588430/an-engineered-complement-factor-h-construct-for-treatment-of-c3-glomerulopathy
#6
Yi Yang, Harriet Denton, Owen R Davies, Kate Smith-Jackson, Heather Kerr, Andrew P Herbert, Paul N Barlow, Matthew C Pickering, Kevin J Marchbank
Background C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway of complement activation, and treatment options for C3G remain limited. Complement factor H (FH) is a potent regulator of the alternative pathway and might offer a solution, but the mass and complexity of FH makes generation of full-length FH far from trivial. We previously generated a mini-FH construct, with FH short consensus repeats 1-5 linked to repeats 18-20 (FH1-5^18-20 ), that was effective in experimental C3G...
March 27, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29584550/association-of-cardiovascular-risk-factors-with-cardiac-events-and-survival-outcomes-among-patients-with-breast-cancer-enrolled-in-swog-clinical-trials
#7
Dawn L Hershman, Cathee Till, Sherry Shen, Jason D Wright, Scott D Ramsey, William E Barlow, Joseph M Unger
Background Cardiovascular disease is the primary cause of death among patients with breast cancer. However, the association of cardiovascular-disease risk factors (CVD-RFs) with long-term survival and cardiac events is not well studied. Methods We examined SWOG (formerly the Southwest Oncology Group) breast cancer trials from 1999 to 2011. We identified baseline diabetes, hypertension, hypercholesterolemia, and coronary artery disease by linking trial records to Medicare claims. The primary outcome was overall survival...
March 27, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29574695/children-and-young-people-s-understanding-of-inherited-conditions-and-their-attitudes-towards-genetic-testing-a-systematic-review
#8
REVIEW
B C McGill, C E Wakefield, J Vetsch, K Barlow-Stewart, N A Kasparian, A F Patenaude, M-A Young, R J Cohn, K M Tucker
Children and young people are increasingly likely to receive information regarding inherited health risks relevant to their genetic relatives and themselves. We reviewed the literature to determine what children and young people (21 years and younger) understand about inherited conditions and their attitudes towards genetic testing. We screened 1815 abstracts to identify 20 studies representing the perspectives of 1811 children and young people between the ages of 6 and 21 years (1498 children or young people at general population-level risk from 9 studies, 313 affected/at-risk from 15 studies)...
March 25, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29510703/a-sophisticated-differentiated-golgi-in-the-ancestor-of-eukaryotes
#9
Lael D Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy, Joel B Dacks
BACKGROUND: The Golgi apparatus is a central meeting point for the endocytic and exocytic systems in eukaryotic cells, and the organelle's dysfunction results in human disease. Its characteristic morphology of multiple differentiated compartments organized into stacked flattened cisternae is one of the most recognizable features of modern eukaryotic cells, and yet how this is maintained is not well understood. The Golgi is also an ancient aspect of eukaryotes, but the extent and nature of its complexity in the ancestor of eukaryotes is unclear...
March 7, 2018: BMC Biology
https://www.readbyqxmd.com/read/29486707/genomic-analysis-in-patients-with-myxomatous-mitral-valve-prolapse-current-state-of-knowledge
#10
S Gasser, H Reichenspurner, E Girdauskas
BACKGROUND: Myxomatous mitral valve prolapse is a common cardiac abnormality. Morbus Barlow is characterized by excess myxomatous leaflet tissue, bileaflet prolapse or billowing, chordae elongation and annular dilatation with or without calcification. Extensive myxoid degeneration with destruction of the normal three-layered leaflet tissue architecture is observed histologically in such patients. Autosomal dominant inheritance with an age and sex-dependent expression has long been recognised...
February 27, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29458304/asbestos-fiber-length-and-its-relation-to-disease-risk
#11
Christy A Barlow, Matthew Grespin, Elizabeth A Best
Differences in chemical and crystalline composition, fiber dimension, aerodynamic characteristics and biodurability are among the critical factors that define the toxicological and pathological consequences of asbestos exposure. Specifically, fiber dimension can impact whether the fiber is respired, whether and how deeply it is deposited in the lung, and how efficiently and rapidly it may be cleared. This paper provides a current, comprehensive evaluation of the weight of evidence regarding the relationship between asbestos fiber length and disease potency (for malignant and nonmalignant endpoints)...
October 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29402929/generation-of-a-rod-specific-nrl-reporter-line-in-human-pluripotent-stem-cells
#12
M Joseph Phillips, Elizabeth E Capowski, Andrew Petersen, Alex D Jansen, Katherine Barlow, Kimberly L Edwards, David M Gamm
Reporter lines generated in human pluripotent stem cells can be highly useful for the analysis of specific cell types and lineages in live cultures. We created the first human rod reporter line using CRISPR/Cas9 genome editing to replace one allele of the Neural Retina Leucine zipper (NRL) gene with an eGFP transgene in the WA09 human embryonic stem cell (hESC) line. After confirming successful targeting, three-dimensional optic vesicle structures were produced to examine reporter specificity and to track rod differentiation in culture...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343464/cardiorespiratory-fitness-coronary-artery-calcium-and-cardiovascular-disease-events-in-a-cohort-of-generally-healthy-middle-aged-men-results-from-the-cooper-center-longitudinal-study
#13
Nina B Radford, Laura F DeFina, David Leonard, Carolyn E Barlow, Benjamin L Willis, Larry W Gibbons, Susan C Gilchrist, Amit Khera, Benjamin D Levine
Background -A robust literature demonstrates that coronary artery calcification (CAC) and cardiorespiratory fitness (CRF) are independent predictors of cardiovascular disease (CVD) events. Much less is known about the joint associations of CRF and CAC with CVD risk. In the setting of high CAC, high versus low CRF has been associated with decreased CVD events. The goal of this study was to assess the impact of continuous levels of CRF on CVD risk in the setting of increasing CAC burden. Methods -We studied 8,425 men without clinical CVD who underwent preventive medicine examinations that included an objective measurement of CRF and CAC between 1998-2007...
January 17, 2018: Circulation
https://www.readbyqxmd.com/read/29340624/early-and-long-term-outcomes-of-mitral-valve-repair-for-barlow-s-disease-a-single-centre-16-year-experience
#14
Anton Tomšic, Yasmine L Hiemstra, Stephanie L van der Pas, Hein Putter, Michel I M Versteegh, Thomas J van Brakel, Nina Ajmone Marsan, Robert J M Klautz, Meindert Palmen
OBJECTIVES: Following mitral valve repair for Barlow's disease, recurrent mitral regurgitation (MR) is believed to occur frequently and is mainly attributed to disease progression. METHODS: Between January 2000 and December 2015, 180 patients (40% women, mean age 58.7 ± 13.5 years) with Barlow's disease underwent mitral valve repair. To provide a longitudinal assessment of mitral valve repair durability, a multistate model for interval-censored observations (4 states: 1, Grade 0/1+ MR; 2, Grade 2+ MR; 3, Grade 3+/4+ MR; 4, reintervention/death) was developed...
January 10, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29284607/weight-loss-and-exercise-alter-the-high-density-lipoprotein-lipidome-and-improve-high-density-lipoprotein-functionality-in-metabolic-syndrome
#15
Anmar A Khan, Piyushkumar A Mundra, Nora E Straznicky, Paul J Nestel, Gerard Wong, Ricardo Tan, Kevin Huynh, Theodore W Ng, Natalie A Mellett, Jacquelyn M Weir, Christopher K Barlow, Zahir H Alshehry, Gavin W Lambert, Bronwyn A Kingwell, Peter J Meikle
OBJECTIVE: High-density lipoprotein (HDL) lipid composition and function may better reflect cardiovascular risk than HDL cholesterol concentration. This study characterized the relationships between HDL composition, metabolism, and function in metabolic syndrome (MetS) patients and how changes in composition after weight loss (WL) and exercise treatments are related to function. APPROACH AND RESULTS: Plasma samples from MetS patients (n=95) and healthy individuals (n=40) were used in this study...
February 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29260322/assessing-n-w-hydroxy-l-arginine-applicability-as-a-novel-ethnic-specific-estrogen-negative-breast-cancer-marker
#16
Srinidi Mohan, Ian Greenstein, Cathy Ng, Kelly Frazier, Giang Nguyen, Lisa Harding, David Barlow
In our prior study we identified Nw -hydroxy-L-arginine (NOHA) as a simple, yet sensitive indicator for estrogen negative (ER- ) breast cancer early-prognosis, but not estrogen positive (ER+ ), and to offer ethnic selectivity for ER- detection. However, the ability of NOHA to assess ER- breast tumor based on disease progression, and tumor severity needs further delineation. Also, the overall NOHA storage stability needs to be validated. To assess the NOHA predictive capability based on disease progression, ER- /ER+ 3D-spheroids (from breast tumor cell lines of human origin) were cultured for 10 weeks...
April 2018: Amino Acids
https://www.readbyqxmd.com/read/29249276/adjunctive-rifampicin-for-staphylococcus-aureus-bacteraemia-arrest-a-multicentre-randomised-double-blind-placebo-controlled-trial
#17
Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Emmanuel Nsutebu, Robert Tilley, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Tim Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin J Llewelyn, Jonathan D Edgeworth, A Sarah Walker
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals...
December 14, 2017: Lancet
https://www.readbyqxmd.com/read/29248417/altered-adamts5-expression-and-versican-proteolysis-a-possible-molecular-mechanism-in-barlow-s-disease
#18
Tarek S Absi, Cristi L Galindo, Richard J Gumina, James Atkinson, Yan Guo, Kelsey Tomasek, Douglas B Sawyer, John G Byrne, Clayton A Kaiser, Ashish S Shah, Yan Ru Su, Michael Petracek
BACKGROUND: We hypothesized that gene expression profiles of mitral valve (MV) leaflets from patients with Barlow's disease (BD) are distinct from those with fibroelastic deficiency (FED). METHODS: MVs were obtained from patients with BD (7 men, 3 women; 61.4 ± 12.7 years old) or FED (6 men, 5 women; 54.5 ± 6.0 years old) undergoing operations for severe mitral regurgitation (MR). Normal MVs were obtained from 6 donor hearts unmatched for transplant (3 men, 3 women; 58...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29233769/historical-evolution-of-regulatory-standards-for-occupational-and-consumer-exposures-to-industrial-talc
#19
REVIEW
Derek A Drechsel, Christy A Barlow, Jennifer L Bare, Neva F Jacobs, John L Henshaw
Talc has been used historically in a wide range of industrial applications and consumer products. The composition and purity of talc used for industrial purposes can vary greatly depending on the source and may contain asbestos minerals. The developing science associated with the health risks of asbestos had an effect on the talc industry throughout the 20th century. This review presents a detailed analysis of the evolution of regulatory standards impacting the use of industrial talc in the U.S. from the early 20th century through the 1990s...
February 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29208613/do-skeletal-muscle-secreted-factors-influence-the-function-of-pancreatic-beta-cells
#20
Jonathan P Barlow, Thomas P J Solomon
Skeletal muscle is an endocrine organ that secretes a variety of compounds including proteins (myokines), metabolites, microRNAs (miRNAs) and exosomes. Many of which are regulated by exercise and play important roles in endocrine signaling. Inter-organ communication via muscle-secreted factors therefore provides a novel area for investigation and implicates the importance of skeletal muscle in the pathophysiology of metabolic diseases such as type 2 diabetes (T2D). Given that underlying molecular mechanisms of T2D is subject of ongoing research, in light of new evidence, it is probable that inter-organ crosstalk between skeletal muscle and pancreatic beta-cells (β-cells) plays an important part...
December 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
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