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https://www.readbyqxmd.com/read/27908253/assessment-of-bone-quality-in-osteoporosis-treatment-with-bone-anabolic-agents-really-something-new
#1
Fabio Massimo Ulivieri, Renata Caudarella, Marzia Camisasca, Daniela Maria Cabrini, Ilaria Merli, Carmelo Messina, Luca Petruccio Piodi
Osteoporosis is a chronic pathologic condition, particularly of the elderly, in which a reduction of bone mineral density (BMD) weakens bone, leading to the so-called fragility fractures, most often of spine and femur. The gold standard exam for the quantitative measurement of BMD is the dual X-ray photon absorptiometry (DXA), a radiological method. However, a relevant number of fragility fractures occurs in the range of normal BMD values, meaning that also qualitative aspects of bone play a role, namely bone architecture and bone geometry...
December 1, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27902711/eeg-to-primary-rewards-predictive-utility-and-malleability-by-brain-stimulation
#2
Nicole Prause, Greg J Siegle, Choi Deblieck, Allan Wu, Marco Iacoboni
Theta burst stimulation (TBS) is thought to affect reward processing mechanisms, which may increase and decrease reward sensitivity. To test the ability of TBS to modulate response to strong primary rewards, participants hypersensitive to primary rewards were recruited. Twenty men and women with at least two opposite-sex, sexual partners in the last year received two forms of TBS. Stimulations were randomized to avoid order effects and separated by 2 hours to reduce carryover. The two TBS forms have been demonstrated to inhibit (continuous) or excite (intermittent) the left dorsolateral prefrontal cortex using different pulse patterns, which links to brain areas associated with reward conditioning...
2016: PloS One
https://www.readbyqxmd.com/read/27900437/bdnf-and-ltp-ltd-like-plasticity-of-the-primary-motor-cortex-in-gilles-de-la-tourette-syndrome
#3
L Marsili, A Suppa, F Di Stasio, D Belvisi, N Upadhyay, I Berardelli, M Pasquini, S Petrucci, M Ginevrino, G Fabbrini, F Cardona, G Defazio, A Berardelli
Gilles de la Tourette syndrome (GTS) is characterized by motor and vocal tics and often associated with obsessive-compulsive disorder (OCD). Responses to intermittent/continuous theta-burst stimulation (iTBS/cTBS), which probe long-term potentiation (LTP)-/depression (LTD)-like plasticity in the primary motor cortex (M1), are reduced in GTS. ITBS-/cTBS-induced M1 plasticity can be affected by brain-derived neurotrophic factor (BDNF) polymorphism. We investigated whether the BDNF polymorphism influences iTBS-/cTBS-induced LTP-/LTD-like M1 plasticity in 50 GTS patients and in 50 age- and sex-matched healthy subjects...
November 30, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27900426/the-lumbar-spine-age-related-degenerative-disease-influences-the-bmd-not-the-tbs-the-osteolaus-cohort
#4
I Padlina, E Gonzalez-Rodriguez, D Hans, M Metzger, D Stoll, B Aubry-Rozier, O Lamy
: We evaluated the influence of degenerative disease and fractured vertebra on lumbar spine bone mineral density (BMD) and trabecular bone score (TBS) in 1500 women aged 50-80 years. TBS was not affected by a degenerative disease. While BMD increases after 62.5 years, TBS continues to decline. TBS should play a leading role in lumbar spine evaluation. INTRODUCTION: After menopause, lumbar spine (LS) BMD and TBS values decrease. Degenerative disease (DD) increases with age and affect LS BMD...
November 30, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27899111/plasmodium-malariae-in-the-colombian-amazon-region-you-don-t-diagnose-what-you-don-t-suspect
#5
Carlos Hernando Niño, Juan Ricardo Cubides, Paola Andrea Camargo-Ayala, Carlos Arturo Rodríguez-Celis, Teódulo Quiñones, Moisés Tomás Cortés-Castillo, Lizeth Sánchez-Suárez, Ricardo Sánchez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
BACKGROUND: Malaria is a worldwide public health problem; parasites from the genus Plasmodium spp. are the aetiological agent of this disease. The parasite is mainly diagnosed by microscope-based techniques. However, these have limited sensitivity. Many asymptomatic infections are sub-microscopic and can only be detected by molecular methods. This study was aimed at comparing nested PCR results to those obtained by microscope for diagnosing malaria and to present epidemiological data regarding malaria in Colombia's Amazon department...
November 29, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27888026/priming-theta-burst-stimulation-enhances-motor-cortex-plasticity-in-young-but-not-old-adults
#6
George M Opie, Eleni Vosnakis, Michael C Ridding, Ulf Ziemann, John G Semmler
BACKGROUND: Primary motor cortex (M1) neuroplasticity is reduced in old adults, which may contribute to the motor deficits commonly observed in the elderly. Previous research in young subjects suggests that the neuroplastic response can be enhanced using non-invasive brain stimulation (NIBS), with a larger plastic response observed following priming with both long-term potentiation (LTP) and depression (LTD)-like protocols. However, it is not known if priming stimulation can also modulate plasticity in older adults...
November 17, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27872582/separate-ionotropic-and-metabotropic-glutamate-receptor-functions-in-depotentiation-vs-ltp-a-distinct-role-for-group1-mglur-subtypes-and-nmdars
#7
Amira Latif-Hernandez, Enrico Faldini, Tariq Ahmed, Detlef Balschun
Depotentiation (DP) is a mechanism by which synapses that have recently undergone long-term potentiation (LTP) can reverse their synaptic strengthening within a short time-window after LTP induction. Group 1 metabotropic glutamate receptors (mGluRs) were shown to be involved in different forms of LTP and long-term depression (LTD), but little is known about their roles in DP. Here, we generated DP by applying low-frequency stimulation (LFS) at 5 Hz after LTP had been induced by a single train of theta-burst-stimulation (TBS)...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27854548/the-benefit-of-menopausal-hormone-therapy-on-bone-density-and-microarchitecture-persists-after-its-withdrawal
#8
Georgios Papadakis, Didier Hans, Elena Gonzalez-Rodriguez, Peter Vollenweider, Gérard Waeber, Pedro Manuel Marques-Vidal, Olivier Lamy
CONTEXT: Menopausal hormone therapy (MHT) favorably affects bone mineral density (BMD). Whether MHT also affects bone microarchitecture, as assessed by trabecular bone score (TBS), has never been evaluated. OBJECTIVE: Our objective was to assess the effect of MHT on TBS and BMD before and after its withdrawal. DESIGN: This was a cross-sectional study. SETTING: This study included the general community. PATIENTS OR OTHER PARTICIPANTS: Data were collected from the OsteoLaus cohort (1500 women aged 50-80 years)...
November 17, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27843274/reasons-for-patronage-of-traditional-bone-setters
#9
Innocent Egbeji Abang, Joseph Asuquo, N E Ngim, Ikpeme Asanye Ikpeme, P Agweye, S E Urom, C Anisi, E Mpama
AIMS AND OBJECTIVES: The objectives of this study were to analyze the different reasons why patients with fractures patronize traditional bone setters (TBS) and their impression of the outcome of the treatment by the TBS. MATERIALS AND METHODS: A 24 month prospective observational study was conducted from February 2012 to January 2014. All the patients were recruited from the orthopedics outpatient clinic. The demographic data of each patient, the type of injury, presentation to hospital or not, reasons for leaving the hospital, reasons for patronage of the TBS and their impression of the outcome of TBS' treatment, effect of educational background on patronage of TBS and reason for presenting to hospital for orthodox treatment...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27834055/biopharmaceutical-assessment-and-irritation-potential-of-microemulsions-and-conventional-systems-containing-oil-from-syagrus-cearensis-for-topical-delivery-of-amphotericin-b-using-alternative-methods
#10
Giovana D Sousa, Juliana Kishishita, Kátia A S Aquino, Octávio A F Presgrave, Leila B Leal, Davi P Santana
The aim of this study was to compare the biopharmaceutical characteristics and irritation potentials of microemulsions (MEs) and conventional systems (CSs) containing oil from Syagrus cearensis for topical delivery of Amphotericin B (AmB). Pseudo-ternary phase diagrams were constructed using a water titration method to develop the MEs, and the CSs were prepared according to the classical technique of phase inversion. In the skin permeation and retention study, dermatomed pig skin without stratum corneum was used as an alternative disturbed skin model...
November 10, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27829765/comparative-study-on-the-tensile-bond-strength-and-marginal-fit-of-complete-veneer-cast-metal-crowns-using-various-luting-agents-an-in-vitro-study
#11
B Devi Parameswari, M Rajakumar, G Lambodaran, Shyam Sundar
INTRODUCTION: Several commercially available luting agents are used to cement the dental restorations such as intra-coronal, extra-coronal, and fixed partial dentures. Tensile bond strength (TBS) and accurate marginal fit are the essential factors to determine the good clinical results in fixed prosthesis. The retentivity of the luting cements is assessed by their adhesive capacity over the tooth surface and metal surface. Generally, the adhesive ability has been evaluated with in vitro testing, with tensile bond tests...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27818473/plasma-lipoprotein-associated-phospholipase-a2-level-is-an-independent-predictor-of-high-thrombus-burden-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#12
Xiangqi Wu, Yingqiang Zhang, Zhiming Wu, Wei You, Fengshuo Liang, Fei Ye, Shaoliang Chen
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for plaque rupture and atherothrombotic events. However, the associations between serum Lp-PLA2 level and thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients remain unknown.We consecutively enrolled 351 STEMI patients who underwent primary percutaneous coronary intervention (pPCI). Patients were assigned to a high thrombus burden (HTB) group (n = 230) and a low thrombus burden (LTB) group (n = 121). Baseline data were recorded during hospital admission...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27814311/effects-of-acoustic-stimulus-duration-on-cervical-vestibular-evoked-myogenic-potentials-a-neurophysiological-and-modeling-study
#13
A Ciardo, N El Assawy, S Mauro, L Priano
OBJECTIVE: To analyze and model the effects of acoustic stimulus duration on cervical vestibular evoked myogenic potentials (cVEMPs). DESIGN: Subjects with normal hearing and no vestibular or cervical disorders were tested using 1 kHz tone bursts (TBs) of different durations to evoke cVEMPs from the ipsilateral sternocleidomastoid muscle. VEMP modeling was performed in Labview. RESULTS: The increase in TB duration initially resulted in a non-linear increase in cVEMP amplitude, followed by more complex cVEMP modifications that were mainly related to the appearance of a new wave (nX) that interfered with n23...
November 3, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27811834/the-prevalence-of-persistent-petrosquamosal-sinus-and-other-temporal-bone-anatomical-variations-on-high-resolution-temporal-bone-computed-tomography
#14
Paweł Bożek, Ewa Kluczewska, Maciej Misiołek, Wojciech Ścierski, Grażyna Lisowska
BACKGROUND The aim of the study was to determine the prevalence of petrosquamosal sinus (PSS) and other temporal bone (TB) anatomical variations in various patients using high-resolution computed tomography (CT). MATERIAL AND METHODS We reviewed clinical and consecutively obtained CT data for 276 TBs of 138 patients. The incidence of TB anatomical variations was compared among patients with radiological markers of chronic otitis media (RCOM) and non-RCOM. RESULTS The PSS incidence in our sample was 6.9%, and it was significantly higher in TBs with RCOM (14...
November 4, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27806942/placental-hypoxia-during-early-pregnancy-causes-maternal-hypertension-and-placental-insufficiency-in-the-hypoxic-guinea-pig-model
#15
Loren P Thompson, Laramie Pence, Gerard Pinkas, Hong Song, Bhanu P Telugu
Chronic placental hypoxia is one of the root causes of placental insufficiencies that result in preeclampsia and maternal hypertension. Chronic hypoxia causes disruption of trophoblast (TB) development, invasion into maternal decidua, and remodeling of maternal spiral arteries. The pregnant guinea pig shares several characteristics with humans such as hemomonochorial placenta, villous subplacenta, deep TB invasion and remodeling of maternal arteries, and is an ideal animal model to study placental development...
November 2, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27805399/synthesis-of-n7-alkyl-9-deaza-2-deoxyguanosines-containing-polar-n7-chains-examples-of-chemically-stable-analogues-of-n7-hydroxyethyl-and-n7-oxoethyl-adducts-of-2-deoxyguanosine
#16
Xun Gao, Haidong Huang
Development of chemically stable analogues of unstable DNA lesions enables accurate study of polymerase bypass. We report the design and synthesis of N7-hydroxyethyl-9-deaza-2'-deoxyguanosine and N7-oxoethyl-9-deaza-2'-deoxyguanosine as the analogues of N7-hydroxyethyl-2'-deoxyguanosine and N7-oxoethyl-2'-deoxyguanosine, respectively. We also developed the synthesis of these two nucleosides whose N7-side chains are protected by TBS for the convenience of conversion to phosphoramidites.
November 2, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27796359/cerebellar-theta-burst-stimulation-modulates-the-neural-activity-of-interconnected-parietal-and-motor-areas
#17
Elias Paolo Casula, Maria Concetta Pellicciari, Viviana Ponzo, Mario Stampanoni Bassi, Domenica Veniero, Carlo Caltagirone, Giacomo Koch
Voluntary movement control and execution are regulated by the influence of the cerebellar output over different interconnected cortical areas, through dentato-thalamo connections. In the present study we applied transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to directly assess the effects of cerebellar theta-burst stimulation (TBS) over the controlateral primary motor cortex (M1) and posterior parietal cortex (PPC) in a group of healthy volunteers. We found a TBS-dependent bidirectional modulation over TMS-evoked activity; specifically, cTBS increased whereas iTBS decreased activity between 100 and 200 ms after TMS, in a similar manner over both M1 and PPC areas...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27783219/long-term-plasticity-in-identified-hippocampal-gabaergic-interneurons-in-the-ca1-area-in-vivo
#18
Petrina Yau-Pok Lau, Linda Katona, Peter Saghy, Kathryn Newton, Peter Somogyi, Karri P Lamsa
Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) in brain slices, but plasticity in these cells has not been tested in vivo. We investigated synaptically-evoked suprathreshold excitation of identified hippocampal neurons in the CA1 area of urethane-anaesthetized rats...
October 25, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27779292/-mandatory-treatment-of-forensic-psychiatric-patients-in-the-netherlands-costs-and-benefits-in-perspective
#19
M H Nagtegaal, K Goethals, G Meynen
So far, it is not known what costs and benefits are connected with the tbs-measure, a measure that involves a mandatory treatment programme for forensic psychiatric patients.<br/> AIM: To explore the costs and benefits that the tbs-measure has on society, on other important stakeholders such as victims and/or next-of-kin and the forensic psychiatric patients themselves. <br/> METHOD: We studied the relevant literature.<br/> RESULTS: The average costs of the tbs-treatment programme are 1.5 million euros...
2016: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/27763897/the-tumor-burden-score-a-new-metro-ticket-prognostic-tool-for-colorectal-liver-metastases-based-on-tumor-size-and-number-of-tumors
#20
Kazunari Sasaki, Daisuke Morioka, Simone Conci, Georgios A Margonis, Yu Sawada, Andrea Ruzzenente, Takafumi Kumamoto, Calogero Iacono, Nikolaos Andreatos, Alfredo Guglielmi, Itaru Endo, Timothy M Pawlik
OBJECTIVE: To apply the principles of the Metro-ticket paradigm to develop a prognostic model for patients undergoing hepatic resection of colorectal liver metastasis (CRLM). BACKGROUND: Whereas the hepatocellular "Metro-ticket" prognostic tool utilizes a continuum of tumor size and number, a similar concept of a CRLM Metro-ticket paradigm has not been investigated. METHODS: Tumor Burden Score (TBS) was defined using distance from the origin on a Cartesian plane incorporating maximum tumor size (x-axis) and number of lesions (y-axis)...
October 19, 2016: Annals of Surgery
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