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https://www.readbyqxmd.com/read/28543544/the-prognostic-utility-of-the-tumor-burden-score-based-on-preoperative-radiographic-features-of-colorectal-liver-metastases
#1
Kazunari Sasaki, Georgios A Margonis, Nikolaos Andreatos, Xu-Feng Zhang, Stefan Buettner, Jaeyun Wang, Amar Deshwar, Jin He, Christopher L Wolfgang, Matthew Weiss, Timothy M Pawlik
BACKGROUND: Recently, a tumor-burden "metro ticket" score (TBS) based on final pathology was proposed to predict outcome following resection of colorectal liver metastasis (CRLM). We sought to validate the TBS prognostic tool using preoperative radiologic cross-sectional imaging. METHODS: Imaging TBS was defined on a Cartesian plane that incorporated both maximum tumor size (x-axis) and lesion number (y-axis) assessed by pre-operative imaging. The discriminatory power (area under the curve [AUC]) and goodness-of-fit (Harrel's C statistic and Somer's D statistics) of the imaging TBS model was assessed...
May 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28541752/ensiled-sugar-beets-as-dietary-component-and-their-effect-on-preference-and-dry-matter-intake-by-goats
#2
Katrin Gerlach, Anke Reimink, Ulrike Messerschmidt, Karl-Heinz Südekum
This study examines the influence of ensiled sugar beets (Beta vulgaris ssp. vulgaris) on preference and short-time dry matter (DM) intake of goats. Whole sugar beets were ensiled either without any silage additive (sugar beet silage (SBS)) or with a chemical additive (6 l/t) containing 85% formic and propionic acids (treated sugar beet silage (TBS)) and were chopped after ensiling. The influence of different proportions of SBS (0%, 6.25%, 12.5%, 18.75% and 25% of dietary DM) and TBS (0%, 5%, 10%, 15% and 20% of DM) in partial mixed rations on short-time DM intake by goats (adult Saanen type wethers; n = 10) was studied in two separate, independent trials...
May 25, 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28539717/caspase-mediated-apoptotic-effects-of-ebenus-boissieri-barbey-extracts-on-human-cervical-cancer-cell-line-hela
#3
Ece Simsek, Nilufer Imir, Esra Arslan Aydemir, Ramazan Suleyman Gokturk, Erdem Yesilada, Kayahan Fiskin
BACKGROUND: Ebenus boissieri Barbey is an Antalya, Turkey-endemic plant belonging to Fabaceae family. The aerial parts and the roots of E. boissieri Barbey were used in this study. OBJECTIVE: In the present study, we have examined the apoptotic effects of hydroalcoholic extracts of E. boissieri Barbey in human cervical cancer cell line HeLa. MATERIALS AND METHODS: To determine the cytotoxic effect, cells were treated with various concentrations of extracts for 24, 48, and 72 h incubation periods...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28534730/big-stimulus-little-ears-safety-in-administering-vestibular-evoked-myogenic-potentials-in-children
#4
Megan L A Thomas, Denis Fitzpatrick, Ryan McCreery, Kristen L Janky
BACKGROUND: Cervical and ocular vestibular-evoked myogenic potentials (VEMPs) have become common clinical vestibular assessments. However, VEMP testing requires high intensity stimuli, raising concerns regarding safety with children, where sound pressure levels may be higher due to their smaller ear canal volumes. PURPOSE: The purpose of this study was to estimate the range of peak-to-peak equivalent sound pressure levels (peSPLs) in child and adult ears in response to high intensity stimuli (i...
May 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28532098/mechanical-behavior-of-yttria-stabilized-tetragonal-zirconia-polycrystalline-ceramic-after-different-zirconia-surface-treatments
#5
Joao Luiz Pozzobon, Gabriel Kalil Rocha Pereira, Vinicius Felipe Wandscher, Lucio Strazzabosco Dorneles, Luiz Felipe Valandro
This study investigated the effects of different zirconia surface conditioning methods on the biaxial flexure strength, surface characteristics and fractographic analysis of a Y-TZP ceramic. Disc-shaped specimens were manufactured according to ISO 6872-2008 for biaxial flexure strength testing, and then randomly assigned into seven groups (n=30). Control (CTRL): without treatment; Tribochemical silica coating (TBS): specimens were sandblasted with silica-coated aluminum oxide particles (CoJet-Sand) for 10s; Silica nanofilm (SNF): specimens were silica coated with a 5nm SiO2 nanofilm; and four protocols of low-fusing porcelain glaze (GLZ): etching with 10% hydrofluoric acid gel (HF) for 1min (GLZ1), 5min (GLZ5), 10min (GLZ10) and 15min (GLZ15)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28516033/the-impact-of-large-structural-brain-changes-in-chronic-stroke-patients-on-the-electric-field-caused-by-transcranial-brain-stimulation
#6
Sena Minjoli, Guilherme B Saturnino, Jakob Udby Blicher, Charlotte J Stagg, Hartwig R Siebner, André Antunes, Axel Thielscher
Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (TDCS) are two types of non-invasive transcranial brain stimulation (TBS). They are useful tools for stroke research and may be potential adjunct therapies for functional recovery. However, stroke often causes large cerebral lesions, which are commonly accompanied by a secondary enlargement of the ventricles and atrophy. These structural alterations substantially change the conductivity distribution inside the head, which may have potentially important consequences for both brain stimulation methods...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28511124/demonstration-of-short-term-plasticity-in-the-dorsolateral-prefrontal-cortex-with-theta-burst-stimulation-a-tms-eeg-study
#7
Sung Wook Chung, Benjamin P Lewis, Nigel C Rogasch, Takashi Saeki, Richard H Thomson, Kate E Hoy, Neil W Bailey, Paul B Fitzgerald
OBJECTIVES: To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex. METHODS: 10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations...
April 24, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28508522/in-situ-observation-of-twin-boundary-sliding-in-single-crystalline-cu-nanowires
#8
Yonghai Yue, Qi Zhang, Xuejiao Zhang, Zhenyu Yang, Penggang Yin, Lin Guo
Using a homemade, novel, in situ transmission electron microscopy (TEM) double tilt tensile device, plastic behavior of single crystalline Cu nanowires of around 150 nm are studied. Deformation twins occur during the tests as predesigned before the experiments. In situ observation of twin boundary sliding (TBS) caused by full dislocation (extended dislocation) is first revealed at the atomic scale which is confirmed by molecular dynamics (MD) simulation results. Combined with twin boundary migration and multiple dislocations nucleated from surface, TBS causes a superlarge fracture strain which is over 166% and a severe necking which is over 93%, far beyond the typical values for most nanomaterials without twins...
May 16, 2017: Small
https://www.readbyqxmd.com/read/28497224/bone-density-microarchitecture-and-material-strength-in-chronic-kidney-disease-patients-at-the-time-of-kidney-transplantation
#9
M J Pérez-Sáez, S Herrera, D Prieto-Alhambra, L Vilaplana, X Nogués, M Vera, D Redondo-Pachón, M Mir, R Güerri, M Crespo, A Díez-Pérez, J Pascual
Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture's estimation. Our chronic kidney disease (CKD) patients presented worse bone health (density, microarchitecture, mechanical properties) than controls. More than BMD should be done to evaluate patients at risk of fracture. INTRODUCTION: BMD measured by dual-energy X-ray absorptiometry (DXA) is used to assess bone health in end-stage renal disease (ESRD) patients...
May 11, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28484733/per-oral-endoscopic-myotomy-for-achalasia-cardia-outcomes-in-over-400-consecutive-patients
#10
Zaheer Nabi, Mohan Ramchandani, Radhika Chavan, Rakesh Kalapala, Santosh Darisetty, Guduru Venkat Rao, Nageshwar Reddy
Background and study aims Per-oral endoscopic myotomy (POEM) has emerged as an efficacious treatment modality for the management of achalasia cardia (AC) and non-achalasia spastic esophageal motility disorders. Initial results are encouraging. We analyzed the safety and efficacy of POEM in a large cohort of patients with AC. Patients and methods The data from patients who underwent POEM (from January 2013 to June 2016) was prospectively collected and analyzed. Clinical success was defined as Eckardt score ≤ 3 after POEM procedure...
May 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28479495/adjusting-frax%C3%A2-on-tbs-for-identification-of-subjects-at-high-risk-of-fractures
#11
G Couraud, C Souffir, E Gaigneux, S Kolta, C Roux, K Briot
The objective of this study was to compare the proportion of patients at high fracture risk according to FRAX® and FRAX® adjusted on TBS in patients hospitalized for a non vertebral fractures. Patients were selected from a Fracture Liaison Service FLS): clinical risk factors, bone mineral density (BMD) and TBS were assessed at the time of the fracture. Without considering the current fracture, we calculated FRAX® and FRAX® adjusted on TBS (TBS-FRAX®), and compared the proportion of patients with a high risk for major osteoporotic fracture (MOF)>20% according to FRAX® and TBS-FRAX®, and the proportion of subjects who should be treated according to current guidelines...
May 4, 2017: Bone
https://www.readbyqxmd.com/read/28461665/tris-buffered-saline-tbs-for-immunoassays
#12
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2017: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/28460834/asymptomatic-plasmodial-infection-in-colombian-pregnant-women
#13
Jaime Carmona-Fonseca, Olga M Agudelo, Eliana M Arango
Information about asymptomatic plasmodial infection is scarce in the world, and the current antimalarial program goals (control, elimination, and eradication) demand this evidence to be well documented in different populations and malaria transmission settings. This study aimed to measure the prevalence of API in Colombian pregnant women at delivery. A retrospective prevalence survey was used. Women were recruited at hospital obstetric facility in each of the municipalities of Turbo, Necoclí in Antioquia department, and Puerto Libertador in Córdoba department...
April 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28458694/submicroscopic-and-asymptomatic-congenital-infection-by-plasmodium-vivax-or-p-falciparum-in-colombia-37-cases-with-placental-histopathology-and-cytokine-profile-in-maternal-and-placental-blood
#14
Olga María Agudelo-García, Eliana María Arango-Flórez, Jaime Carmona-Fonseca
Problem. Congenital plasmodial infection (CPI) is a rare event, which has been little studied in Colombia. Objective. To measure the frequency of CPI and to describe the immune and histological characteristics in maternal blood and placentas when CPI occurs. Methodology. A cross-sectional study was carried out in northwest Colombia. A sample size of 39 unit analysis (a unit of analysis corresponds to the cord, placenta, and peripheral blood of a pregnant woman) was calculated using epidemiological and statistical parameters...
2017: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28457756/antitubulin-effects-of-aminobenzothiophene-substituted-triethylated-chromones
#15
Yukiko Kobayashi, Yohei Saito, Masuo Goto, Kyoko Nakagawa-Goto
In the course of our continuing studies on the 2-(benzo[b]thiophene-3'-yl)-6,8,8-triethyldesmosdumotin B (TEDB-TB) series, we designed and synthesized nine amino-TEDB-TB derivatives to improve pharmaceutical properties, identify structure activity relationships, and discover novel antitubulin agents. Among all newly synthesized amino-TEDB-TBs, the 5'- and 6'-amino derivatives, 6 and 7, exhibited significant antiproliferative activity against five human tumor cell lines, including an MDR subline overexpressing P-gp...
April 19, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28453635/peak-bone-mass-and-bone-microarchitecture-in-adults-born-with-low-birth-weight-preterm-or-at-term-a-cohort-study
#16
Chandima Balasuriya, Kari Anne I Evensen, Mats P Mosti, Ann-Mari Brubakk, Geir W Jacobsen, Marit S Indredavik, Berit Schei, Astrid Kamilla Stunes, Unni Syversen
Context and objectives: Peak bone mass (PBM) is regarded as the most important determinant of osteoporosis. Growing evidence suggests a role of intrauterine programming in skeletal development. We examined PBM and trabecular bone score (TBS) in adults born preterm with very low birth weight (VLBW) or small for gestational age (SGA) at term compared with term-born controls. Design, setting, participants and outcomes: This follow-up cohort study included 186 men and women (25-28 years); 52 preterm VLBW (≤ 1500g), 59 term-born SGA (< 10th percentile), and 75 controls (>10th percentile)...
April 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28449351/long-term-plasticity-of-corticostriatal-synapses-is-modulated-by-pathway-specific-co-release-of-opioids-through-kappa-opioid-receptors
#17
Sarah L Hawes, Armando G Salinas, David M Lovinger, Kim T Blackwell
Synaptic plasticity in striatum adjusts behaviour adaptively during skill learning, or maladaptively in the case of addiction. Just as dopamine plays a critical role in synaptic plasticity underlying normal skill learning and addiction, endogenous and exogenous opiates also modulate learning and addiction-related striatal plasticity. Though the role of opioid receptors in long-term depression in striatum has been characterized, their effect on long-term potentiation (LTP) remains unknown. In particular, direct pathway (Dopamine D1 Receptor containing; D1R) - spiny projection neurons (SPNs) co-release the opioid neuropeptide dynorphin, which acts at presynaptic kappa opioid receptors (KORs) on dopaminergic afferents and can negatively regulate dopamine release...
April 27, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28418990/bone-density-microarchitecture-and-tissue-quality-following-long-term-treatment-with-tenofovir-emtricitabine-or-abacavir-lamivudine
#18
Robert Güerri-Fernández, Daniel Molina-Morant, Judit Villar-García, Sabina Herrera, Alicia González-Mena, Ana Guelar, Marta Trenchs-Rodríguez, Adolfo Díez-Pérez, Hernando Knobel
OBJECTIVES: HIV infection has been associated with reduced bone mineral density (BMD). Antiretroviral therapy has a deleterious effect on BMD, but its effect on bone fragility is not clear. The objective of this study is to analyze the BMD, microarchitecture and tissue quality of bone in patients receiving long-term tenofovir- or abacavir-based antiretroviral therapy. DESIGN: We conducted a cross-sectional study in HIV patients undergoing tenofovir or abacavir antiretroviral therapy for more than five years...
April 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28405729/dietary-acid-load-trabecular-bone-integrity-and-mineral-density-in-an-ageing-population-the-rotterdam-study
#19
E A L de Jonge, F Koromani, A Hofman, A G Uitterlinden, O H Franco, F Rivadeneira, J C Kiefte-de Jong
We studied the relation between a diet that is high in acid-forming nutrients (e.g. proteins) and low in base-forming nutrients (e.g. potassium) and bone structure. We showed a negative relation, which was more prominent if proteins were of animal rather than of vegetable origin and if intake of dietary fibre was high. INTRODUCTION: Studies on dietary acid load (DAL) and fractures have shown inconsistent results. Associations between DAL, bone mineral density (BMD) and trabecular bone integrity might play a role in these inconsistencies and might be influenced by renal function and dietary fibre intake...
April 12, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28404455/modulation-of-itbs-after-effects-via-concurrent-directional-tdcs-a-proof-of-principle-study
#20
Sara Tremblay, Ricci Hannah, Vishal Rawji, John C Rothwell
BACKGROUND: Polarising currents can modulate membrane potentials in animals, affecting the after-effect of theta burst stimulation (TBS) on synaptic strength. OBJECTIVE: We examined whether a similar phenomenon could also be observed in human motor cortex (M1) using transcranial direct current stimulation (TDCS) during monophasic intermittent TBS (iTBS). METHODS: TDCS was applied during posterior-anterior iTBS using three different conditions: posterior-anterior TDCS (anode 3...
March 23, 2017: Brain Stimulation
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