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https://www.readbyqxmd.com/read/28912097/igg-subclasses-quantitation-analytical-performance-of-the-binding-site-spaplus%C3%A2-human-assay-and-comparison-with-siemens-bnii%C3%A2-assay
#1
Ana Sarnago, Rosa M Pascual, María J Moreno, Begoña Laíz, Oscar Fuster
OBJECTIVES: Accurate evaluation of analyzers is highly recommended before these devices are broadly introduced for routine testing. Concerning quantification of IgG subclasses (IgGSc), standardization has not yet been reached and thus different assays might lead to different results. Here we report the analytical performances of The Binding Site (TBS) SPAPLUS® human IgGSc assay and the concordance with the Siemens BNII® human IgGSc assay. DESIGN AND METHODS: We evaluated precision, LoB, LoD and linearity of TBS SPAPLUS® human IgGSc immunoassay...
September 11, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28894415/loss-of-fmrp-impaired-hippocampal-long-term-plasticity-and-spatial-learning-in-rats
#2
Yonglu Tian, Chaojuan Yang, Shujiang Shang, Yijun Cai, Xiaofei Deng, Jian Zhang, Feng Shao, Desheng Zhu, Yunbo Liu, Guiquan Chen, Jing Liang, Qiang Sun, Zilong Qiu, Chen Zhang
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene that inactivate expression of the gene product, the fragile X mental retardation 1 protein (FMRP). In this study, we used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology to generate Fmr1 knockout (KO) rats by disruption of the fourth exon of the Fmr1 gene. Western blotting analysis confirmed that the FMRP was absent from the brains of the Fmr1 KO rats (Fmr1(exon4-KO) )...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28885315/tuberous-breast-past-present-and-future-personal-classification-treatment-and-surgical-outcomes
#3
Alessandro Innocenti, Marco Innocenti, Francesco Mori, Dario Melita, Francesco Ciancio, Adriana Cordova
BACKGROUND: Tuberous breast (TB) is a rare congenital deformity, which may appear in different clinical forms representing various degrees of a single pathological entity. The worst cases are characterized by severe hypoplasia. Following a detailed analysis of the available relevant literature and a significant number of treated cases, in this article, the authors propose a new classification, with the aim of summarizing and simplifying a more intuitive categorization of the malformation, considering all the clinical aspects and including all types of TBs, even the minor ones, thus allowing a more immediate diagnosis and surgical planning...
September 6, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28884422/less-strict-intervention-thresholds-for-the-frax-and-tbs-adjusted-frax-predict-clinical-fractures-in-osteopenic-postmenopausal-women-with-no-prior-fractures
#4
Martin Kužma, Didier Hans, Tomáš Koller, Eva Némethová, Peter Jackuliak, Zdenko Killinger, Heinrich Resch, Juraj Payer
Little is known about the clinical relevance of treating post-menopausal women with no prior history of fragility fracture and bone mineral densities (BMD) within the osteopenic range. In recent years, in addition to BMD and FRAX fracture probability assessments, a surrogate measure of bone micro-architecture quality, called the trabecular bone score (TBS), has been proven to predict future fragility fractures independently of both BMD and the FRAX. In this retrospective analysis of a follow-up study, we compared three risk assessment instruments-the FRAX, the TBS, and a TBS-adjusted FRAX score-in their ability, to predict future fragility fractures over a minimum of five years of follow-up among post-menopausal osteopenic women with no prior fragility fractures...
September 7, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28881444/gabaergic-inhibition-gates-excitatory-ltp-in-perirhinal-cortex
#5
Vibhakar C Kotak, Ana Mirallave, Todd M Mowery, Dan H Sanes
The perirhinal cortex (PRh) is a key region downstream of auditory cortex (ACx) that processes familiarity linked mnemonic signaling. In gerbils, ACx-driven EPSPs recorded in PRh neurons are largely shunted by GABAergic inhibition (Kotak et al. 2015). To determine whether inhibitory shunting prevents the induction of excitatory long-term potentiation (e-LTP), we stimulated ACx-recipient PRh in a brain slice preparation using theta burst stimulation (TBS). Under control conditions, without GABA blockers, the majority of PRh neurons exhibited long-term depression...
September 7, 2017: Hippocampus
https://www.readbyqxmd.com/read/28875602/poorly-differentiated-clusters-in-colorectal-adenocarcinomas-share-biological-similarities-with-micropapillary-patterns-as-well-as-tumor-buds
#6
Mineui Hong, Jeong Won Kim, Mi Kyung Shin, Byung Chun Kim
In colorectal carcinoma, poorly differentiated clusters (PDCs) are a poor prognostic indicator and show morphological continuity and behavioral similarities to micropapillary patterns (MPPs) as well as tumor buds (TBs). Epithelial-mesenchymal transition (EMT) and inhibition of cancer-stromal interactions may contribute to the development of PDCs. To clarify the biological nature of PDCs, we examined immunohistochemical stainings for β-catenin, Ki-67, E-cadherin, epithelial cell adhesion molecule (EpCAM), MUC1, and epithelial membrane antigen (EMA), which are associated with EMT and cancer-stromal interactions...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28868588/maternal-vitamin-d-and-offspring-trabecular-bone-score
#7
N K Hyde, S L Brennan-Olsen, J D Wark, S M Hosking, K L Holloway, J A Pasco
No studies have explored the relationship with maternal vitamin D (25(OH)D) in pregnancy and offspring trabecular bone score (TBS). Our data suggest that maternal 25(OH)D in early pregnancy, but not late, may be associated with offspring TBS in boys. These data act as hypothesis-generating findings for confirmation in larger, longer-term studies. INTRODUCTION: Trabecular bone score (TBS), a novel tool derived from dual-energy X-ray absorptiometry (DXA), reflects the microarchitecture of the vertebrae...
September 3, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28867993/impact-of-prefrontal-theta-burst-stimulation-on-clinical-neuropsychological-tasks
#8
Raquel Viejo-Sobera, Diego Redolar-Ripoll, Mercè Boixadós, Marc Palaus, Antoni Valero-Cabré, Elena M Marron
Theta burst stimulation (TBS) protocols hold high promise in neuropsychological rehabilitation. Nevertheless, their ability to either decrease (continuous, cTBS) or increase (intermittent, iTBS) cortical excitability in areas other than the primary motor cortex, and their consistency modulating human behaviors with clinically relevant tasks remain to be fully established. The behavioral effects of TBS over the dorsolateral prefrontal cortex (dlPFC) are particularly interesting given its involvement in working memory (WM) and executive functions (EF), often impaired following frontal brain damage...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28857846/utility-of-trabecular-bone-score-in-the-evaluation-of-osteoporosis
#9
Patrick Martineau, Barbara C Silva, William D Leslie
PURPOSE OF REVIEW: Trabecular bone score (TBS) is a lumbar spine dual-energy absorptiometry texture index which provides information on skeletal quality partially independent of bone mineral density (BMD). A body of work has emerged demonstrating the relationship between TBS and fracture risk, with lower TBS values associated with increased risk for osteoporotic fracture in postmenopausal women and older men. TBS is derived from standard DXA images; however, the information provided by TBS is complementary to that provided by BMD...
August 28, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28851789/brain-stimulation-for-arm-recovery-after-stroke-b-stars-protocol-for-a-randomised-controlled-trial-in-subacute-stroke-patients
#10
Eline C C van Lieshout, Johanna M A Visser-Meily, Sebastiaan F W Neggers, H Bart van der Worp, Rick M Dijkhuizen
INTRODUCTION: Many patients with stroke have moderate to severe long-term sensorimotor impairments, often including inability to execute movements of the affected arm or hand. Limited recovery from stroke may be partly caused by imbalanced interaction between the cerebral hemispheres, with reduced excitability of the ipsilesional motor cortex while excitability of the contralesional motor cortex is increased. Non-invasive brain stimulation with inhibitory repetitive transcranial magnetic stimulation (rTMS) of the contralesional hemisphere may aid in relieving a post-stroke interhemispheric excitability imbalance, which could improve functional recovery...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28842728/discrepancy-between-bone-density-and-bone-material-strength-index-in-three-siblings-with-camurati-engelmann-disease
#11
S Herrera, R Soriano, X Nogués, R Güerri-Fernandez, D Grinberg, N García-Giralt, N Martínez-Gil, S Castejón, A González-Lizarán, S Balcells, A Diez-Perez
Camurati-Engelmann (CE) is a very rare disease affecting one in every million persons worldwide. It is characterized by an enlargement of long bones. We aimed to assess bone characteristics in three siblings with different tools. Even if there was an excess of bone density, quality seemed to be deteriorated. INTRODUCTION: CE disease is a rare monogenic disorder affecting approximately one in every million persons worldwide. It is mainly characterized by a progressive hyperostosis of the periosteum and endosteum of the diaphysis of long bones...
August 25, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28842648/size-effects-of-lamellar-twins-on-the-strength-and-deformation-mechanisms-of-nanocrystalline-hcp-cobalt
#12
Wen Wang, Fuping Yuan, Ping Jiang, Xiaolei Wu
Twins play an important role in the deformation of nanocrystalline (NC) metals. The size effects of {[Formula: see text]} tensile/{[Formula: see text]} compressive lamellar twins on the tensile strength and deformation mechanisms of NC hcp cobalt have been investigated by a series of large-scale molecular dynamics simulations. Unlike the size effects of twins on the strength for polycrystalline fcc metals, the strength of NC hcp cobalt with lamellar tensile/compressive twins monotonically increases with decreasing twin boundary spacing (TBS) and no softening stage is observed, which is due to the consistent deformation mechanisms no matter TBS is large or small...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28829934/retentive-strength-of-y-tzp-crowns-comparison-of-different-silica-coating-methods-on-the-intaglio-surfaces
#13
V F Wandscher, C Prochnow, M P Rippe, L S Dorneles, G L Callegari, P Baldissara, R Scotti, L F Valandro
OBJECTIVE: To evaluate the effect of different methods of silica deposition on the intaglio surface of yttrium oxide stabilized zirconia polycrystal (Y-TZP) crowns on the retentive strength of the crowns. METHODS: One hundred simplified full-crown preparations produced from fiber-reinforced polymer material were scanned, and 100 Y-TZP crowns with occlusal retentions were milled. Crown/preparation assemblies were randomly allocated into five groups (n=20) according to the treatment of the intaglio surfaces: TBS = tribochemical silica coating via air-abrasion with 30-μm silica-coated alumina particles; GHF1 = application of thin glaze layer + hydrofluoric acid (HF) etching for 1 minute; GHF5 = glaze application + HF for 5 minutes; GHF15 = glaze application + HF for 15 minutes; NANO = silica nanofilm deposition (5 nm) via magnetron sputtering...
September 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28827961/uncaria-tomentosa-willd-ex-schult-dc-rubiaceae-sensitizes-thp-1-cells-to-radiation-induced-cell-death
#14
Lisa Allen, Alison Buckner, Carly A Buckner, Pablo Cano, Robert M Lafrenie
BACKGROUND: Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae), known as Cat's Claw or Uña de gato, is a traditionally used medicinal plant native to Peru. Some studies have shown that U. tomentosa can act as an antiapoptotic agent and enhance DNA repair in chemotherapy-treated cells although others have shown that U. tomentosa enhanced apoptosis. OBJECTIVE: To determine if treatment with U. tomentosa can significantly enhance cell death in THP-1 cells exposed to ionizing radiation...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28827456/thioredoxin-and-nadph-dependent-thioredoxin-reductase-c-regulation-of-tetrapyrrole-biosynthesis
#15
Qingen Da, Peng Wang, Menglong Wang, Ting Sun, Honglei Jin, Bing Liu, Jinfa Wang, Bernhard Grimm, Hong-Bin Wang
In chloroplasts, thioredoxin (TRX) isoforms and NADPH-dependent thioredoxin reductase C (NTRC) act as redox regulatory factors involved in multiple plastid biogenesis and metabolic processes. To date, less is known about the functional coordination between TRXs and NTRC in chlorophyll (Chl) biosynthesis. In this study, we aimed to explore the potentially functions of TRX m and NTRC in the regulation of the tetrapyrrole biosynthesis (TBS) pathway. Silencing of three genes, TRX m1, TRX m2, and TRX m4 (TRX ms), led to pale-green leaves, a significantly reduced 5-aminolevulinic acid (ALA)-synthesizing capacity, and reduced accumulation of Chl and its metabolic intermediates in Arabidopsis thaliana...
August 21, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28821456/hyperglycemia-is-associated-with-increased-bone-mineral-density-and-decreased-trabecular-bone-score-in-elderly-japanese-men-the-fujiwara-kyo-osteoporosis-risk-in-men-formen-study
#16
Masayuki Iki, Yuki Fujita, Katsuyasu Kouda, Akiko Yura, Takahiro Tachiki, Junko Tamaki, Renaud Winzenrieth, Yuho Sato, Jong-Seong Moon, Nozomi Okamoto, Norio Kurumatani
PURPOSE: Patients with type 2 diabetes mellitus (T2DM) have an increased fracture risk despite having higher areal bone mineral density (aBMD). This study aimed to clarify the association between glycemic and insulin resistance status and bone microarchitecture, and whether pentosidine and bone turnover markers play any roles in the association. METHODS: A total of 2012 community-dwelling men aged ≥65years completed baseline measurements of spine aBMD, fasting plasma glucose (FPG) and serum insulin, hemoglobin A1c (HbA1c), osteocalcin, type I procollagen N-terminal propeptide, type I collagen C-terminal crosslinking telopeptide, tartrate-resistant acid phosphatase isoenzyme 5b, pentosidine, height and weight and an interview regarding past disease history...
August 15, 2017: Bone
https://www.readbyqxmd.com/read/28796083/a-new-slim-modiolar-electrode-array-for-cochlear-implantation-a-radiological-and-histological-study
#17
Matti Iso-Mustajärvi, Hanna Matikka, Frank Risi, Sini Sipari, Teemu Koski, Tytti Willberg, Antti Lehtimäki, Jyrki Tervaniemi, Heikki Löppönen, Aarno Dietz
HYPOTHESIS: To explore the results of a new slim modiolar electrode array (SMA) with respect to intracochlear placement and trauma evaluated by detailed radiologic imaging and histology. BACKGROUND: Hearing and structure preservation is the goal of cochlear implantation for advanced hearing outcomes. Currently, this is most consistently achieved with thin lateral wall electrodes. Modiolar electrodes are located nearer the modiolus and may provide some electrophysiological advantages, but have a greater tendency for causing insertion trauma...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28782579/safety-of-carotid-artery-stent-in-repetitive-transcranial-magnetic-stimulation-the-histopathological-proof-from-swine-carotid-artery
#18
Po-Yu Fong, Wen-Yu Chuang, Ying-Zu Huang, Chien-Hung Chang
INTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS), including theta burst stimulation (TBS), is considered helpful for functional recovery in post-stroke patients. However, the safety is a common concern forusingr TMS for neuro-rehabilitation and research in patients with stents. METHOD: Prolonged continuous theta burst stimulation (cTBS) with 1200 pulses at 50% of maximum output of Magstim Super Rapid2 was delivered in three different angles to a carotid stent placed in an isolated fresh swine carotid artery or on a table at a distance of 5cm...
August 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28772427/bonding-to-different-peek-compositions-the-impact-of-dental-light-curing-units
#19
Nina Lümkemann, Marlis Eichberger, Bogna Stawarczyk
This study investigated the impact of different light curing units (LCUs) for the polymerization of adhesive system visio.link (VL) on the tensile bond strength (TBS) of different PEEK compositions. For TBS measurements, 216 PEEK specimens with varying amounts of TiO₂ (PEEK/0%, PEEK/20%, PEEK/>30%) were embedded, polished, air abraded (Al₂O₃, 50 µm, 0.4 MPa), conditioned using VL, and polymerized using either a halogen LCU (HAL-LCU) or a LED LCU (LED-LCU) for chairside or labside application, respectively...
January 14, 2017: Materials
https://www.readbyqxmd.com/read/28766140/assessment-of-the-effects-of-switching-oral-bisphosphonates-to-denosumab-or-daily-teriparatide-in-patients-with-rheumatoid-arthritis
#20
Kosuke Ebina, Makoto Hirao, Jun Hashimoto, Keisuke Hagihara, Masafumi Kashii, Kazuma Kitaguchi, Hozo Matsuoka, Toru Iwahashi, Ryota Chijimatsu, Hideki Yoshikawa
The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 65.9 years, lumbar spine (LS) T score -1.8, femoral neck (FN) T score -2.3, dose and rate of taking oral prednisolone (3.6 mg/day) 75.8%, and prior BP treatment duration 40.0 months. The patients were allocated to (1) the BP-continue group (n = 80), (2) the switch-to-DMAb group (n = 74), or (3) the switch-to-TPTD group (n = 40)...
August 1, 2017: Journal of Bone and Mineral Metabolism
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