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https://www.readbyqxmd.com/read/28796083/a-new-slim-modiolar-electrode-array-for-cochlear-implantation-a-radiological-and-histological-study
#1
Matti Iso-Mustajärvi, Hanna Matikka, Frank Risi, Sini Sipari, Teemu Koski, Tytti Willberg, Antti Lehtimäki, Jyrki Tervaniemi, Heikki Löppönen, Aarno Dietz
HYPOTHESIS: To explore the results of a new slim modiolar electrode array (SMA) with respect to intracochlear placement and trauma evaluated by detailed radiologic imaging and histology. BACKGROUND: Hearing and structure preservation is the goal of cochlear implantation for advanced hearing outcomes. Currently, this is most consistently achieved with thin lateral wall electrodes. Modiolar electrodes are located nearer the modiolus and may provide some electrophysiological advantages, but have a greater tendency for causing insertion trauma...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28782579/safety-of-carotid-artery-stent-in-repetitive-transcranial-magnetic-stimulation-the-histopathological-proof-from-swine-carotid-artery
#2
Po-Yu Fong, Wen-Yu Chuang, Ying-Zu Huang, Chien-Hung Chang
INTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS), including theta burst stimulation (TBS), is considered helpful for functional recovery in post-stroke patients. However, the safety is a common concern forusingrTMS for neuro-rehabilitation and research in patients with stents. METHOD: Prolonged continuous theta burst stimulation (cTBS) with 1200 pulses at 50% of maximum output of Magstim Super Rapid2 was delivered in three different angles to a carotid stent placed in an isolated fresh swine carotid artery or on a table at a distance of 5cm...
August 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28772427/bonding-to-different-peek-compositions-the-impact-of-dental-light-curing-units
#3
Nina Lümkemann, Marlis Eichberger, Bogna Stawarczyk
This study investigated the impact of different light curing units (LCUs) for the polymerization of adhesive system visio.link (VL) on the tensile bond strength (TBS) of different PEEK compositions. For TBS measurements, 216 PEEK specimens with varying amounts of TiO₂ (PEEK/0%, PEEK/20%, PEEK/>30%) were embedded, polished, air abraded (Al₂O₃, 50 µm, 0.4 MPa), conditioned using VL, and polymerized using either a halogen LCU (HAL-LCU) or a LED LCU (LED-LCU) for chairside or labside application, respectively...
January 14, 2017: Materials
https://www.readbyqxmd.com/read/28766140/assessment-of-the-effects-of-switching-oral-bisphosphonates-to-denosumab-or-daily-teriparatide-in-patients-with-rheumatoid-arthritis
#4
Kosuke Ebina, Makoto Hirao, Jun Hashimoto, Keisuke Hagihara, Masafumi Kashii, Kazuma Kitaguchi, Hozo Matsuoka, Toru Iwahashi, Ryota Chijimatsu, Hideki Yoshikawa
The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 65.9 years, lumbar spine (LS) T score -1.8, femoral neck (FN) T score -2.3, dose and rate of taking oral prednisolone (3.6 mg/day) 75.8%, and prior BP treatment duration 40.0 months. The patients were allocated to (1) the BP-continue group (n = 80), (2) the switch-to-DMAb group (n = 74), or (3) the switch-to-TPTD group (n = 40)...
August 1, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28760591/the-hairy-lizard-heterothermia-affects-anaesthetic-requirements-in-the-arabian-oryx-oryx-leucoryx
#5
Mads F Bertelsen, Osama Mohammed, Tobias Wang, Paul R Manger, David Michael Scantlebury, Khairi Ismael, Nigel C Bennett, Abdulaziz Alagaili
OBJECTIVE: To study the effect of heterothermia on anaesthetic drug requirements in semi-free ranging Arabian oryx and to assess the temperature quotient (Q10) of oxygen consumption. STUDY DESIGN: Prospective observational study and controlled metabolic experiment. ANIMALS: Sixty-eight anaesthetic events in 59 Arabian oryx from Mahazat As-Sayd protected area, Saudi Arabia METHODS: Anaesthesia was induced by remote injection of 25 mg ketamine, 10 mg midazolam and 0...
March 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28756994/dual-energy-x-ray-absorptiometry-predictors-of-vertebral-deformities-in-beta-thalassemia-major
#6
Giangiacomo Osella, Adriano Massimiliano Priola, Sandro Massimo Priola, Antonio Piga, Filomena Longo, Massimo Ventura, Giuseppe Bentivegna, Alberto Angeli, Andrea Veltri, Massimo Terzolo
Vertebral fractures in beta-thalassemia major are increasingly found because of the longer life expectancy of patients, with a major negative impact on their quality of life. We performed a retrospective cross-sectional study to investigate the prevalence of vertebral deformities in thalassemic patients and to identify their best dual-energy X-ray absorptiometry (DXA) predictor among trabecular bone score (TBS), bone mineral density (BMD), and Z-score. Eighty-two outpatients with beta-thalassemia major on regular conventional treatment were studied at a single academic center...
July 27, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28748386/effect-of-denosumab-on-trabecular-bone-score-in-postmenopausal-women-with-osteoporosis
#7
M R McClung, K Lippuner, M L Brandi, J R Zanchetta, H G Bone, R Chapurlat, D Hans, A Wang, C Zapalowski, C Libanati
Trabecular bone score (TBS) assesses bone quality in the lumbar spine using dual-energy X-ray absorptiometry (DXA) scans. In postmenopausal women with osteoporosis, denosumab significantly improved TBS independently of bone mineral density (BMD). This practical technique may have a role in managing patients with osteoporosis. INTRODUCTION: TBS, a gray-level texture index determined from lumbar spine DXA scans, correlates with bone microarchitecture and enhances assessment of vertebral fracture risk independently of BMD...
July 26, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28743851/-new-methods-for-the-evaluation-of-bone-quality-dxa-based-analysis-of-bone-quality-trabecular-bone-score-tbs
#8
Teruki Sone
Trabecular bone score(TBS)is a texture measure that evaluates pixel gray-level variations in lumbar spine DXA images, and provides skeletal information distinct from the standard BMD measurement. Recent clinical evidences show that TBS is associated with fracture risk in primary and secondary osteoporosis, and can be used together with FRAX(R) and BMD to adjust FRAX-probability of fracture in postmenopausal women and older men. However, athough treatment-related increases are reflected in the TBS, these are considerably smaller than the changes in BMD and there is insufficient evidence that TBS can be used to assess response to pharmacologic treatment...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28743845/-new-methods-for-the-evaluation-of-bone-quality-diseases-affecting-bone-quality
#9
Shinsuke Yamada, Masaaki Inaba
Impaired bone quality is associated with fragility bone fractures independently of bone mineral density. Lifestyle disease-induced osteoporosis, such as diabetes or chronic kidney disease, and glucocorticoid-induced osteoporosis are listed as the diseases affecting bone quality. TBS(trabecular bone score)developed recently will be able to evaluate the trabecular microarchitecture quickly and easily. Various clinical studies evaluated bone quality by TBS has performed. I give an outline about the diseases affecting bone quality...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28734710/use-of-trabecular-bone-score-tbs-as-a-complementary-approach-to-dual-energy-x-ray-absorptiometry-dxa-for-fracture-risk-assessment-in-clinical-practice
#10
Enisa Shevroja, Olivier Lamy, Lynn Kohlmeier, Fjorda Koromani, Fernando Rivadeneira, Didier Hans
Osteoporosis is a common bone disease characterized by low bone mass and altered bone microarchitecture, resulting in decreased bone strength with an increased risk of fractures. In clinical practice, physicians can assess the risk of fracture for a patient based on several risk factors. Some such as age, weight, and history of fractures after 50 years of age, parental fracture, smoking status, and alcohol intake are incorporated into FRAX, an assessment tool that estimates the 10-year probability of hip fracture and major osteoporotic fractures based on the individual's risk factors profile...
July 19, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28733715/clinical-performance-of-an-updated-trabecular-bone-score-tbs-algorithm-in-men-and-women-the-manitoba-bmd-cohort
#11
G I Schacter, W D Leslie, S R Majumdar, S N Morin, L M Lix, D Hans
This is the first study to directly compare the original and recently updated versions of the trabecular bone score (TBS) algorithm. We confirmed improved performance of the new algorithm, especially among men. INTRODUCTION: Lumbar spine trabecular bone score (TBS) predicts major osteoporotic fractures (MOFs) and hip fractures (HFs) independent of bone density. The original TBS algorithm (version 1; [TBS-v1]) was optimized for women of average body size. Limitations were identified when used in men or extremes of body mass index (BMI)...
July 21, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28727341/-use-of-trabecular-bone-score-as-a-complementary-approach-to-dxa-for-fracture-risk-assessment-in-clinical-practice
#12
Didier Hans, Enisa Shevroja, Olivier Lamy
Physicians can assess the risk of fracture based on bone density (BMD) and several risk factors. Some of them and BMD are incorporated into FRAX, an assessment tool that estimates the 10-years probability of fracture. BMD didn't take into account the microarchitecture. TBS is a texture parameter related to bone microarchitecture. A low TBS is associated with a history of fracture and the incidence of new fracture independently of BMD, clinical risk factors and FRAX. TBS is yet integrated in the FRAX tool, and this effect is of greatest utility for individuals who are close to an intervention threshold...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28712983/older-age-and-higher-body-mass-index-are-associated-with-a-more-degraded-trabecular-bone-score-compared-to-bone-mineral-density
#13
Young Ho Shin, Hyun Sik Gong, Kyung Jae Lee, Goo Hyun Baek
Trabecular bone score (TBS) may detect subjects with a more degraded microarchitecture but whose bone mineral density (BMD) reflects normal or osteopenia. The purpose of this study was to evaluate whether age and body sizes were associated with the discordance between BMD and TBS. We analyzed BMD and TBS in 1505 Korean women over 40 yr of age who had no history of osteoporotic fractures or conditions that affect bone metabolism. We considered 3 groups to have TBS values that reflected a more degraded TBS than their BMD values: (1) normal BMD but partially degraded TBS, (2) normal BMD but degraded TBS, and (3) osteopenia but degraded TBS...
July 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28701927/activation-of-the-creb-c-fos-pathway-during-long-term-synaptic-plasticity-in-the-cerebellum-granular-layer
#14
Daniela Gandolfi, Silvia Cerri, Jonathan Mapelli, Mariarosa Polimeni, Simona Tritto, Marie-Therese Fuzzati-Armentero, Albertino Bigiani, Fabio Blandini, Lisa Mapelli, Egidio D'Angelo
The induction of long-term potentiation and depression (LTP and LTD) is thought to trigger gene expression and protein synthesis, leading to consolidation of synaptic and neuronal changes. However, while LTP and LTD have been proposed to play important roles for sensori-motor learning in the cerebellum granular layer, their association with these mechanisms remained unclear. Here, we have investigated phosphorylation of the cAMP-responsive element binding protein (CREB) and activation of the immediate early gene c-Fos pathway following the induction of synaptic plasticity by theta-burst stimulation (TBS) in acute cerebellar slices...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28701388/should-we-restrict-vitamin-a-intake-a-minor-contributor-to-plasma-retinol-turnover-when-using-retinol-isotope-dilution-equations-to-estimate-an-individual-s-vitamin-a-status-or-should-vitamin-a-balance-be-maintained
#15
Jennifer Lynn Ford, Joanne Balmer Green, Michael H Green
We discuss whether dietary vitamin A intake should be restricted or maintained at balance when retinol isotope dilution equations are applied to estimate an individual's vitamin A total body stores (TBS) after oral administration of a labeled dose of vitamin A. Although, at first glance, restriction makes sense as a way to prevent dilution of tracer in plasma, further investigation of the assumptions underlying the widely used isotope dilution equation presented by Olson's laboratory in 1989, as well as the compartmental modeling results presented in this article, indicate that, in fact, restriction leads to an incorrect prediction of TBS if steady state retinol isotope dilution equations are applied at the traditional time (21 d)...
August 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28693786/skeletal-involvement-in-type-1-gaucher-disease-not-just-bone-mineral-density
#16
M Baldini, G Casirati, F M Ulivieri, E Cassinerio, K Khouri Chalouhi, E Poggiali, L Borin, V Burghignoli, B M Cesana, M D Cappellini
Gaucher disease is characterized by multi-organ infiltration of phospholipid-laden macrophages. Bone involvement is characterized by typical deformities, osteopenia/osteoporosis, pathological fractures, and bone marrow infiltration (avascular osteonecrosis, infarction). Estimation of skeletal disease includes bone quality that contributes substantially to bone strength. We studied 23 type 1 Gaucher patients (median age 22years, range 3-73) on Enzyme Replacement Therapy from 2months to 26years (median 7years); 4 patients had pathological fractures, 10 bone infarctions, 6 avascular osteonecrosis...
June 16, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28693017/the-bethesda-system-for-reporting-cervical-cytology-a-historical-perspective
#17
Ritu Nayar, David C Wilbur
The aims of The Bethesda System (TBS) were to provide effective communication from the laboratory to the clinical provider; facilitate cytologic-histologic correlation; facilitate research into the epidemiology, biology, and pathology of cervical disease; and provide reproducible and reliable data for national and international statistical analysis comparisons. Dr. Diane Solomon and colleagues' contribution to cervical cancer screening, diagnosis, and management began with the inception and dissemination of TBS for reporting cervical cytology in 1988, as detailed in the accompanying article [Solomon et al...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28686305/nanoscopic-analysis-of-oxygen-segregation-at-tilt-boundaries-in-silicon-ingots-using-atom-probe-tomography-combined-with-tem-and-ab-initio-calculations
#18
Y Ohno, K Inoue, K Fujiwara, K Kutsukake, M Deura, I Yonenaga, N Ebisawa, Y Shimizu, K Inoue, Y Nagai, H Yoshida, S Takeda, S Tanaka, M Kohyama
We have developed an analytical method to determine the segregation levels on the same tilt boundaries (TBs) at the same nanoscopic location by a joint use of atom probe tomography and scanning transmission electron microscopy, and discussed the mechanism of oxygen segregation at TBs in silicon ingots in terms of bond distortions around the TBs. The three-dimensional distribution of oxygen atoms was determined at the typical small- and large-angle TBs by atom probe tomography with a low impurity detection limit (0...
July 7, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28685886/longitudinal-adaptations-of-bone-mass-geometry-and-metabolism-in-adolescent-male-athletes-the-pro-bone-study
#19
Dimitris Vlachopoulos, Alan R Barker, Esther Ubago-Guisado, Ioannis G Fatouros, Karen M Knapp, Craig A Williams, Luis Gracia-Marco
Adolescence is a crucial period for bone development, and exercise can enhance bone acquisition during this period of life. However, it is not known how the different loading sports practiced can affect bone acquisition in adolescent male athletes. Therefore, the purpose of the present study was to determine the 1-year longitudinal bone acquisition among adolescent males involved in osteogenic (football) and non-osteogenic (swimming and cycling) sports and to compare with active controls. A total of 116 adolescent males aged 12 to 14 years at baseline were followed for 1 year: 37 swimmers, 37 footballers, 28 cyclists, and 14 active controls...
July 7, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28684748/in-plane-anisotropy-and-twin-boundary-effects-in-vanadium-nitride-under-nanoindentation
#20
Tao Fu, Xianghe Peng, Cheng Huang, Henggao Xiang, Shayuan Weng, Zhongchang Wang, Ning Hu
Twin boundaries (TBs) have been observed in and introduced into nonmetallic materials in recent years, which brought new concepts for the design of new structural materials. However, the roles of TB on the mechanical properties and strengthening/softening of transition metal nitrides remain unclear. To investigate the TB effects and the in-plane anisotropy, nanoindentations on VN (111) films with and without TB were simulated with molecular dynamics, in which a cylindrical indenter was used, and its longitudinal axis were assigned along <112> and <110>, respectively...
July 6, 2017: Scientific Reports
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