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https://www.readbyqxmd.com/read/29681948/regeneration-of-tracheal-tissue-in-partial-defects-using-porcine-small-intestinal-submucosa
#1
Nelson Bergonse Neto, Lianna Ferrari Jorge, Julio C Francisco, Bruna Olandoski Erbano, Barbara Evelin Gonçalves Barboza, Larissa Luvison Gomes da Silva, Marcia Olandoski, Katherine Athayde Teixeira de Carvalho, Luiz Felipe Pinho Moreira, Jose Rocha Faria Neto, Eltyeb Abdelwahid, Luiz Cesar Guarita-Souza
Background: Surgical correction of tracheal defects is a complex procedure when the gold standard treatment with primary end-to-end anastomosis is not possible. An alternative treatment may be the use of porcine small intestinal submucosa (SIS). It has been used as graft material for bioengineering applications and to promote tissue regeneration. The aim of this study was to evaluate whether SIS grafts improved tracheal tissue regeneration in a rabbit model of experimental tracheostomy...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29680325/effects-of-severe-hallux-valgus-on-metatarsal-stress-and-the-metatarsophalangeal-loading-during-balanced-standing-a-finite-element-analysis
#2
Yan Zhang, Jan Awrejcewicz, Olga Szymanowska, Siqin Shen, Xiaoxue Zhao, Julien S Baker, Yaodong Gu
The internal stress of the human foot enables efficient parametric evaluation of structural and functional impairments associated with foot deformities, such as hallux valgus (HV). However, the status of the internal stress of such a deformed foot remains insufficiently addressed due to the difficulties and limitations of experimental approaches. This study, using finite element (FE) methodology, investigated the influence of severe HV deformity on the metatarsal stress and the metatarsophalangeal (MTP) joint loading during balanced standing...
April 16, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29680264/temporary-inhibition-of-the-plasminogen-activator-inhibits-periosteal-chondrogenesis-and-promotes-periosteal-osteogenesis-during-appendicular-bone-fracture-healing
#3
D Bravo, A M Josephson, V Bradaschia-Correa, M Z Wong, N L Yim, S S Neibart, S N Lee, J Huo, T Coughlin, M M Mizrahi, P Leucht
INTRODUCTION: Aminocaproic acid is approved as an anti-fibrinolytic for use in joint replacement and spinal fusion surgeries to limit perioperative blood loss. Previous animal studies have demonstrated a pro-osteogenic effect of aminocaproic acid in spine fusion models. Here, we tested if aminocaproic acid enhances appendicular bone healing and we sought to uncover the effect of aminocaproic acid on osteoprogenitor cells (OPCs) during bone regeneration. METHODS: We employed a well-established murine femur fracture model in adult C57BL/6J mice after receiving two peri-operative injections of aminocaproic acid...
April 19, 2018: Bone
https://www.readbyqxmd.com/read/29679101/t2-mapping-of-the-sacroiliac-joints-at-1-5-tesla-a-feasibility-and-reproducibility-study
#4
Domenico Albano, Vito Chianca, Renato Cuocolo, Rodolfo Bignone, Francesco Ciccia, Luca Maria Sconfienza, Massimo Midiri, Arturo Brunetti, Roberto Lagalla, Massimo Galia
OBJECTIVE: To evaluate the reproducibility of T2 relaxation time measurements of the sacroiliac joints at 1.5 T. MATERIALS AND METHODS: Healthy volunteers underwent an oblique axial multislice multiecho spin-echo sequence of the sacroiliac joints at 1.5 T. Regions of interest were manually drawn using a dedicated software by two musculoskeletal radiologists to include the cartilaginous part of the sacroiliac joints. A senior radiologist performed the measurement twice, while a resident measured once...
April 20, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29669195/early-fetal-development-of-the-otic-and-pterygopalatine-ganglia-with-special-reference-to-the-topographical-relationship-with-the-developing-sphenoid-bone
#5
Masahito Yamamoto, Kwang Ho Cho, Gen Murakami, Shinichi Abe, Jose Francisco Rodríguez-Vázquez
The otic and pterygopalatine ganglia are located close to the greater wing (alisphenoid) of the sphenoid bone and many researchers have noted nerves connecting these ganglia in human embryos. The greater wing (alisphenoid) arises from the cartilaginous ala temporalis independently of the lesser wing, but no topographical changes between this cartilage and nerve elements have been demonstrated. We examined histological sections of 20 human embryos and fetuses from 6 to 15 weeks of development (WD). At 6 WD, the ala temporalis, the alar process and ganglia were all identified as a single, undifferentiated cell mass...
April 18, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29665137/morphological-development-of-baculum-and-forelimb-second-to-fourth-digit-ratio-in-mice
#6
Minami Fuse, Kazuhiko Sawada
The baculum (or os penis) is the non-appendicular osseous tissue owned by nine orders of mammals. In rodents, the baculum consists of three segments derived from developmentally-distinct origins: proximal endochondral, central intramembranous and distal cartilaginous segments (Murakami and Mizuno 1984). This report attempted to assess a contribution of physiological levels of prenatal testosterone to the mouse baculal morphology.
April 17, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29664923/effect-of-cartilaginous-endplates-on-extruded-disc-resorption-in-lumbar-disc-herniation
#7
Kenichi Kawaguchi, Katsumi Harimaya, Yoshihiro Matsumoto, Mitsumasa Hayashida, Seiji Okada, Keiichiro Iida, Go Kato, Kuniyoshi Tsuchiya, Toshio Doi, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima
OBJECTIVE: The aim of this study was to investigate the clinicopathologic features of lumbar disc herniation (LDH) with endplate degeneration and the association between cartilaginous fragments and inflammatory response to the herniated disc. SUMMARY OF BACKGROUND DATA: LDH often involves hyaline cartilage fragments pulled from the vertebral endplates. Modic changes are closely associated with LDH that contains hyaline cartilage, and cartilaginous endplates seem to affect resorption of the herniated disc...
2018: PloS One
https://www.readbyqxmd.com/read/29657458/bizarre-parosteal-osteochondromatous-proliferation-16-cases-with-a-focus-on-histologic-variability
#8
Margaret Cocks, Elizabeth Helmke, Carolyn A Meyers, Laura Fayad, Edward McCarthy, Aaron W James
Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign bone and cartilage forming tumor occurring on the surface of bones, predominantly on the hands and feet. A defining feature of BPOP is the purplish-blue mineralization of cartilaginous tissue, known as 'blue bone.' Here, we report on an institutional series of 16 cases of BPOP, including radiographic, histologic, and histomorphometric features. All tumors were composed of some element of bone, cartilage, fibrous tissue and 'blue bone,' though the amount of each tissue sub-type varied widely...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656316/the-role-of-adenosine-receptor-activation-in-attenuating-cartilaginous-inflammation
#9
REVIEW
Jonathan M Bekisz, Christopher D Lopez, Carmen Corciulo, Aranzazu Mediero, Paulo G Coelho, Lukasz Witek, Roberto L Flores, Bruce N Cronstein
Adenosine receptor activation has been explored as a modulator of the inflammatory process that propagates osteoarthritis. It has been reported that cartilage has enhanced regenerative potential when influenced by adenosine receptor activation. As adenosine's role in maintaining chondrocyte homeostasis at the cellular and molecular levels is explored, successful in vivo applications of adenosine delivery for cartilage repair continue to be reported. This review summarizes the role adenosine receptor ligation plays in chondrocyte homeostasis and regeneration of articular cartilage damaged in osteoarthritis...
April 14, 2018: Inflammation
https://www.readbyqxmd.com/read/29653160/a-computational-model-for-the-joint-onset-and-development
#10
Kalenia M Márquez-Flórez, James R Monaghan, Sandra J Shefelbine, Angélica Ramirez-Martínez, Diego A Garzón-Alvarado
Joints connect the skeletal components and enable movement. The appearance and development of articulations is due to different genetic, biochemical, and mechanical factors. In the embryonic stage, controlled biochemical processes are critical for organized growth. We developed a computational model, which predicts the appearance, location, and development of joints in the embryonic stage. Biochemical events are modeled with reaction diffusion equations with generic molecules representing molecules that 1) determine the site where the articulation will appear, 2) promote proliferation, and matrix synthesis, and 3) define articular cartilage...
April 10, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29652862/inhibitory-effects-of-human-primary-intervertebral-disc-cells-on-human-primary-osteoblasts-in-a-co-culture-system
#11
Rahel D May, Daniela A Frauchiger, Christoph E Albers, Lorin M Benneker, Sandro Kohl, Benjamin Gantenbein
Spinal fusion is a common surgical procedure to address a range of spinal pathologies, like damaged or degenerated discs. After the removal of the intervertebral disc (IVD), a structural spacer is positioned followed by internal fixation, and fusion of the degenerated segment by natural bone growth. Due to their osteoinductive properties, bone morphogenetic proteins (BMP) are applied to promote spinal fusion. Although spinal fusion is successful in most patients, the rates of non-unions after lumbar spine fusion range from 5% to 35%...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29644076/lost-in-translation-the-3-utr-of-igf1r-as-an-ancient-long-noncoding-rna
#12
Avantika Mainieri, David Haig
Background and objectives: The insulin-like growth factor (IGF) signaling system is a major arena of intragenomic conflict over embryonic growth between imprinted genes of maternal and paternal origin and the IGF type 1 receptor (IGF1R) promotes proliferation of many human cancers. The 3'-untranslated region (3'-UTR) of the mouse Igf1r mRNA is targeted by miR-675-3p derived from the imprinted H19 long noncoding RNA. We undertook a comparative sequence analysis of vertebrate IGF1R 3'-UTRs to determine the evolutionary history of miR-675 target sequences and to identify conserved features that are likely to be involved in post-transcriptional regulation of IGF1R translation...
2018: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/29629793/3d-ultrashort-te-mri-for-evaluation-of-cartilaginous-endplate-of-cervical-disk-in-vivo-feasibility-and-correlation-with-disk-degeneration-in-t2-weighted-spin-echo-sequence
#13
Yeo Ju Kim, Jang Gyu Cha, Yoon Sang Shin, Akshay S Chaudhari, Young Ju Suh, Seung Hwan Yoon, Garry E Gold
OBJECTIVE: The purpose of this study was to evaluate the feasibility of 3D ultrashort TE (UTE) MRI in depicting the cartilaginous endplate (CEP) and its abnormalities and to investigate the association between CEP abnormalities and disk degeneration on T2-weighted spin-echo (SE) MR images in cervical disks in vivo. SUBJECTS AND METHODS: Eight healthy volunteers and 70 patients were examined using 3-T MRI with the 3D UTE cones trajectory technique (TR/TE, 16.1/0...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29628715/solitary-osteochondroma-of-the-capitate-in-a-child
#14
Nikolaos A Laliotis, Chrysanthos K Crysanthou, Panagiotis A Konstandinidis
Osteochondromas, are the most common tumors of the long bones in children. Osteochondromas are extremely rare in the carpal bones. They are diagnosed in adult life, in almost all cases in the literature. We report a 7 year old boy, who presented with a hard mass on the dorsum of his hand, with decreased wrist movements. Radiological examination showed a calcified tumor of the second row of the carpal bones, with spherical shape and covered with cartilage. He was surgically treated with removal of a cartilaginous mass that was arising from the capitate...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29624714/two-cases-of-discrete-adenoid-pseudogland-formation-within-benign-intradermal-melanocytic-nevi
#15
Jonathan C Banta, Justin P Bandino
We report two cases of benign intradermal melanocytic nevi with discrete glandular elements and mucin deposition engendering a diagnostic dilemma. The preliminary differential included entrapment of adnexal structures, collision with an adnexal neoplasm such as adenoid cystic carcinoma, or metastatic adenocarcinoma. A colloidal iron special stain confirmed the deposition of mucin, however a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative. Closer cytological examination of the discrete "glands" combined with nearby pseudoangiomatous (almost Kaposiform) change hinted at melanocytic origin, and was confirmed with a positive MART-1 immunohistochemical stain...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29621303/time-dependent-regulation-of-morphological-changes-and-cartilage-differentiation-markers-in-the-mouse-pubic-symphysis-during-pregnancy-and-postpartum-recovery
#16
Bianca Gazieri Castelucci, Sílvio Roberto Consonni, Viviane Souza Rosa, Lucimara Aparecida Sensiate, Paula Cristina Rugno Delatti, Lúcia Elvira Alvares, Paulo Pinto Joazeiro
Animal models commonly serve as a bridge between in vitro experiments and clinical applications; however, few physiological processes in adult animals are sufficient to serve as proof-of-concept models for cartilage regeneration. Intriguingly, some rodents, such as young adult mice, undergo physiological connective tissue modifications to birth canal elements such as the pubic symphysis during pregnancy; therefore, we investigated whether the differential expression of cartilage differentiation markers is associated with cartilaginous tissue morphological modifications during these changes...
2018: PloS One
https://www.readbyqxmd.com/read/29618867/nasal-reconstruction-with-pre-laminated-forehead-flap
#17
N S Prasanna
Loss of nasal skin as well as loss of both lateral alar cartilages and vestibular lining with exposure of septum presents a grotesque deformity by itself, with further danger of loss of nasal bones and other cartilaginous structures leading to total loss of nose. The Goal of the treatment is to restore the skin cover as well as lining and cartilage support, restoring nose while avoiding the deformity. In an elderly patient with Spiritual restrictions, with diabetes and Hypertension, the treatment was needed to be carried out under local anesthesia as a daycare procedure...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29618816/the-evolutionary-history-of-vertebrate-rna-viruses
#18
Mang Shi, Xian-Dan Lin, Xiao Chen, Jun-Hua Tian, Liang-Jun Chen, Kun Li, Wen Wang, John-Sebastian Eden, Jin-Jin Shen, Li Liu, Edward C Holmes, Yong-Zhen Zhang
Our understanding of the diversity and evolution of vertebrate RNA viruses is largely limited to those found in mammalian and avian hosts and associated with overt disease. Here, using a large-scale meta-transcriptomic approach, we discover 214 vertebrate-associated viruses in reptiles, amphibians, lungfish, ray-finned fish, cartilaginous fish and jawless fish. The newly discovered viruses appear in every family or genus of RNA virus associated with vertebrate infection, including those containing human pathogens such as influenza virus, the Arenaviridae and Filoviridae families, and have branching orders that broadly reflected the phylogenetic history of their hosts...
April 4, 2018: Nature
https://www.readbyqxmd.com/read/29618719/cervical-esophagotomy-for-foreign-body-extraction-a-case-report-and-extensive-literature-review-of-the-last-20-years
#19
Pasquale Cianci, Nicola Tartaglia, Amedeo Altamura, Alessandra Di Lascia, Alberto Fersini, Vincenzo Neri, Antonio Ambrosi
BACKGROUND Voluntary and involuntary ingestion of foreign bodies is a common condition; in most cases they pass through the digestive tract, but sometimes they stop, creating emergency situations for the patient. We report a case of meat bolus with cartilaginous component impacted in the cervical esophagus, with a brief literature review. CASE REPORT A 64-year-old man came to our attention for retention in the cervical esophagus of a piece of meat accidentally swallowed during lunch. After a few attempts of endoscopic removal carried out previously in other hospitals, the patient has been treated by us with a cervical esophagotomy and removal of the foreign body, without any complications...
April 5, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29615564/sonic-hedgehog-signaling-and-development-of-the-dentition
#20
REVIEW
Maisa Seppala, Gareth J Fraser, Anahid A Birjandi, Guilherme M Xavier, Martyn T Cobourne
Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates. Signal transduction is involved in early specification of the tooth-forming epithelium in the oral cavity, and, ultimately, in defining tooth number within the established dentition. Shh also promotes the morphogenetic movement of epithelial cells in the early tooth bud, and influences cell cycle regulation, morphogenesis, and differentiation in the tooth germ...
May 31, 2017: Journal of Developmental Biology
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