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Yeliz Akturk, Serra Ozbal Gunes
PURPOSE: This study aims to determine the normal limits of atlanto-dental interval (ADI), basion-dens interval (BDI), basion-cartilaginous dens interval (BCDI), and prevertebral soft tissue thickness (PVSTT) according to age groups for normal pediatric cases. MATERIALS AND METHODS: CT images of 256 pediatric patients aged between 1 and 15 years were retrospectively evaluated. ADI, BDI, BCDI and PVSTT measurements were performed. RESULTS: Upper normal limit (UNL) values for ADI were 2...
June 19, 2018: Japanese Journal of Radiology
Ubaidullo Kurbonov, Abdumalik Davlatov, Sitora Janobilova, Ziyodullo Kurbanov, Massoud Mirshahi
Background: Auricular reconstruction is 1 of the biggest challenges of facial plastic surgery. The aim of this study was to evaluate the efficacy of 1-stage reconstruction of an auricle using a temporoparietal fascia flap (TPFF). Methods: In this nonrandomized study, autologous auricle bodies with emergency condition and cartilaginous graft from projection of a costal arch from the VI-VII ribs were used. Temporal fascia sample with vascular pedicle (a temporal artery with the accompanying veins) by the Z-shaped incision of skin in temporal area for auricular reconstruction was extracted...
May 2018: Plastic and Reconstructive Surgery. Global Open
Kevin A Henry, C Roger MacKenzie
Single-domain antibodies (sdAbs), the autonomous variable domains of heavy chain-only antibodies produced naturally by camelid ungulates and cartilaginous fishes, have evolved to bind antigen using only three complementarity-determining region (CDR) loops rather than the six present in conventional VH :VL antibodies. It has been suggested, based on limited evidence, that sdAbs may adopt paratope structures that predispose them to preferential recognition of recessed protein epitopes, but poor or non-recognition of protuberant epitopes and small molecules...
June 19, 2018: MAbs
Catarina Leite Pereira, Graciosa Q Teixeira, Joana R Ferreira, Matteo D'Este, David Eglin, Mauro Alini, Sibylle Grad, Mario Barbosa, Raquel Goncalves
Intervertebral disc (IVD) degeneration is characterized by an unbalanced cell catabolic/anabolic activity and cell death, resulting in the degradation of extracellular matrix (ECM) components and water loss. Repopulating the IVD with new cells may help recovering tissue homeostasis and revert the degenerative process. Here the regenerative potential of a hyaluronan based (HA)-chemoattractant delivery system able to recruit Mesenchymal Stem Cells (MSCs) seeded on the cartilaginous endplate (CEP) of IVD was explored...
June 19, 2018: Tissue Engineering. Part A
L Chadli, C Steltzlen, P Beaufils, C Toanen, N Pujol
PURPOSE: The goal of the fixation of painful osteochondritis dissecans of the femoral condyles in adults is to integrate the osteochondral fragment and thus achieve a normal hyaline cartilaginous coverage. The addition of a biological process to primary fixation may result in improved fragment integration (hybrid fixation). Osteochondral plugs may fulfil this role. The aim of this study was to evaluate long-term clinical and radiological results after hybrid fixation of unstable osteochondritis dissecans...
June 19, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Emna Ben Slimane, Saloua Sadok
The acid solubilised collagen (ASC) and pepsin solubilised collagen (PSC) were extracted from the by-products (skin) of a cartilaginous fish ( Mustelus mustelus ). The ASC and PSC yields were 23.07% and 35.27% dry weight, respectively and were identified as collagen Type I with the presence of α, β and γ chains. As revealed by the Fourier Transform Infrared (FTIR) spectra analysis, pepsin did not alter the PSC triple helix structure. Based on the various type of collagen yield, only PSC was used in combination with chitosan to produce a composite film...
June 15, 2018: Marine Drugs
Pamela F Weiss, Walter P Maksymowych, Robert G Lambert, Jacob L Jaremko, David M Biko, Joel Paschke, Timothy G Brandon, Rui Xiao, Nancy A Chauvin
OBJECTIVE: There is a critical need for measures to evaluate structural progression in the pediatric sacroiliac joint (SIJ). We aimed to evaluate the construct validity and reliability of the Spondyloarthritis Research Consortium of Canada SIJ Structural Score (SSS) in children with suspected or confirmed juvenile spondyloarthritis. METHODS: The SSS assesses structural lesions of the SIJ on magnetic resonance imaging (MRI) through the cartilaginous part of the joint...
June 15, 2018: Journal of Rheumatology
Marketa Kaucka, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Eleni Kastriti, Meng Xie, Anna Kicheva, Karl Annusver, Maria Kasper, Orsolya Symmons, Leslie Pan, Francois Spitz, Jozef Kaiser, Maria Hovorakova, Tomas Zikmund, Kazunori Sunadome, Michael P Matise, Hui Wang, Ulrika Marklund, Hind Abdo, Patrik Ernfors, Pascal Maire, Maud Wurmser, Andrei S Chagin, Kaj Fried, Igor Adameyko
Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium...
June 13, 2018: ELife
Sergey V Guselnikov, Konstantin O Baranov, Alexander M Najakshin, Ludmila V Mechetina, Nikolai A Chikaev, Alexey I Makunin, Sergey V Kulemzin, Daria A Andreyushkova, Matthias Stöck, Sven Wuertz, Jörn Gessner, Wesley C Warren, Manfred Schartl, Vladimir A Trifonov, Alexander V Taranin
The aim of this study was to fill important gaps in the evolutionary history of immunoglobulins by examining the structure and diversity of IgL genes in non-teleost ray-finned fish. First, based on the bioinformatic analysis of recent transcriptomic and genomic resources, we experimentally characterized the IgL genes in the chondrostean fish, Acipenser ruthenus (sterlet). We show that this species has three loci encoding IgL kappa-like chains with a translocon-type gene organization and a single VJC cluster, encoding homogeneous lambda-like light chain...
2018: Frontiers in Immunology
Pravin Salunke, Madhivanan Karthigeyan, Sushanta K Sahoo, Narasimhaiah Sunil
OBJECTIVE: Congenital atlanto-axial dislocation (CAAD) often manifests in younger age group. Softer bones, deformed joints and the concern of fusing multiple segments in growing age set apart this subset of patients from adults. Objectives of this manuscript are to discuss the challenges faced and subsequent solutions during multiplanar realignment and fusion (short segment) of C1-2 joints through a direct posterior approach in pediatric CAAD. PATIENTS & METHODS: 56 pediatric patients with CAAD were operated through a direct posterior approach in the last 4 years...
June 5, 2018: Clinical Neurology and Neurosurgery
Wei Yuan, Zhen-Xi Li, Cheng-Long Zhao, Tian-Hui Hou, Si-Wang Hu, Wei-Bo Liu, Feng-Lai Yuan, Jian-Ru Xiao
BACKGROUND: Context: Endothelin-1 (ET-1) is an inflammatory mediator associated with cartilage endplate (CEP) degeneration in the intervertebral disc. SOX9 is down-regulated during CEP degeneration, along with its targets, collagen II and aggrecan. Wnt/β-catenin signaling is associated with CEP degeneration and a downstream target of SOX9; however, the precise mechanism of CEP degeneration and the role of ET-1 are largely unknown. PURPOSE: The purpose of the study was to evaluate the influence of the endothelin A receptor antagonist, BQ-123, on ET-1-induced effects on cartilaginous endplate cells (CECs) associated with CEP degeneration via the Wnt/β-catenin signaling pathway...
June 7, 2018: Spine Journal: Official Journal of the North American Spine Society
Matthias C Wurm, Tessa K Behrends, Wolfgang Wüst, Marco Wiesmüller, Andre Wilkerling, Friedrich W Neukam, Tilo Schlittenbauer
INTRODUCTION: Magnetic resonance imaging has been established as the gold standard for assessment of the temporomandibular joint. Apart from an excellent assessment of the soft tissues it has the advantage not to expose the patient to ionizing radiation. There is a lack of literature concerning the correlation between pain intensity and radiological findings of the temporomandibular joint. Moreover there is the question of whether a progressive degeneration of the cartilaginous components is accompanied by an increasing degeneration of the osseous parts of the mandibular joint and vice versa...
January 4, 2018: Journal of Cranio-maxillo-facial Surgery
Oleksandr Yaryhin, Ingmar Werneburg
The sand lizard, Lacerta agilis, is a classical model species in herpetology. Its adult skull anatomy and its embryonic development are well known. The description of its fully formed primordial skull by Ernst Gaupp, in 1900, was a key publication in vertebrate morphology and influenced many comparative embryologists. Based on recent methodological considerations, we restudied the early cranial development of this species starting as early as the formation of mesenchymal condensations up to the fully formed chondrocranium...
June 8, 2018: Journal of Morphology
Kayla C Hall, Peter J Hundt, John D Swenson, Adam P Summers, Karen D Crow
Batoids are a diverse clade of flat cartilaginous fishes that occur primarily in benthic marine habitats. The skates and rays typically use their flexible pectoral fins for feeding and propulsion via undulatory swimming. However, two groups of rays have adopted a pelagic or bentho-pelagic lifestyle and utilize oscillatory swimming-the Myliobatidae and Gymnuridae. The myliobatids have evolved cephalic lobes, anteriorly extended appendages that are optimized for feeding, while their pectoral fins exhibit several modifications that likely arose in association with functional optimization of pelagic cruising via oscillatory flight...
June 7, 2018: Journal of Morphology
Nisha Gadgil, I-Wen Pan, Solomon Babalola, Sandi Lam
BACKGROUND: The American College of Surgeons' National Surgical Quality Improvement Program-Pediatric (NSQIP-P) risk calculator was developed based on national data. There have been no studies assessing the risk calculator's performance in pediatric neurosurgery. The authors aimed to evaluate the predictions from the risk calculator compared to our single institution experience in craniosynostosis surgery. METHODS: Outcomes from craniosynostosis surgeries performed between 2012 and 2016 at our academic pediatric hospital were evaluated using the NSQIP-P risk calculator...
June 5, 2018: Journal of Craniofacial Surgery
Franck Accadbled, Daniel N'Dele
Management of pediatric articular fractures has evolved over the years with a growing interest in arthroscopic handling. Several factors account for this recent appeal among which are progress in technology with increased availability of diagnostic methods, rise in athletic activities responsible for these fractures, and pediatric orthopaedic surgeons getting familiar with arthroscopic techniques. In our institution, 9 of 100 arthroscopic procedures are performed as a consequence of an articular fracture. In total, 80% of the fractures concern the knee (56% of tibial eminence fracture, 24% osteochondral fracture)...
July 2018: Journal of Pediatric Orthopedics
Mazen El Rafei, Sammy Badr, Guillaume Lefebvre, Francois Machuron, Benoist Capon, Rene-Marc Flipo, Anne Cotten
OBJECTIVE: To describe the appearance of the anatomical variations of the sacroiliac joints (SIJ) on MR images and to highlight the potential MR features that might be misleading. METHODS: Consecutive MRI examinations of SIJs performed at our department from January 2015 to December 2016 were retrospectively analyzed. As one of our goals was to describe potential misleading edematous or structural changes associated with SIJ anatomical variations, patients fulfilling the ASAS criteria were excluded from this study to ensure that signal intensity changes would not be related to sacroiliitis...
June 6, 2018: European Radiology
Giuseppe Marramà, Giorgio Carnevale, Andrea Engelbrecht, Kerin M Claeson, Roberto Zorzin, Mariagabriella Fornasiero, Jürgen Kriwet
Here, we review and discuss the records and taxonomy of the Ypresian (Eocene) chondrichthyans from the famous Bolca Konservat-Lagerstätte in northeastern Italy. Despite the outstanding diversity and the numerous studies focusing on the actinopterygian faunas from Pesciara and Monte Postale, the current knowledge about the systematics, taxonomy and phylogenetic relationships of the cartilaginous fishes from these Eocene sites remains elusive and largely inadequate. The celebrated Eocene Bolca Lagerstätte has yielded several exquisitely preserved articulated remains of chondrichthyan fishes in which delicate structures and soft tissues are preserved, as well as isolated teeth...
2018: Paläontologische Zeitschrift
Benjamin Fritz, Daniel A Müller, Reto Sutter, Moritz C Wurnig, Matthias W Wagner, Christian W A Pfirrmann, Michael A Fischer
OBJECTIVES: The aim of this study was to assess the interreader agreement and diagnostic accuracy of morphologic magnetic resonance imaging (MRI) analysis and quantitative MRI-based texture analysis (TA) for grading of cartilaginous bone tumors. MATERIALS AND METHODS: This retrospective study was approved by our local ethics committee. Magnetic resonance imaging scans of 116 cartilaginous bone neoplasms were included (53 chondromas, 26 low-grade chondrosarcomas, 37 high-grade chondrosarcomas)...
May 31, 2018: Investigative Radiology
Nick J Besselink, Koen L Vincken, L Wilbert Bartels, Ronald J van Heerwaarden, Arno N Concepcion, Anne C A Marijnissen, Sander Spruijt, Roel J H Custers, Jan-Ton A D van der Woude, Karen Wiegant, Paco M J Welsing, Simon C Mastbergen, Floris P J G Lafeber
Objective High tibial osteotomy (HTO) and knee joint distraction (KJD) are treatments to unload the osteoarthritic (OA) joint with proven success in postponing a total knee arthroplasty (TKA). While both treatments demonstrate joint repair, there is limited information about the quality of the regenerated tissue. Therefore, the change in quality of the repaired cartilaginous tissue after KJD and HTO was studied using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). Design Forty patients (20 KJD and 20 HTO), treated for medial tibiofemoral OA, were included in this study...
June 1, 2018: Cartilage
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