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https://www.readbyqxmd.com/read/28653201/chondrolipoma-of-the-breast-as-a-rare-variant-of-myofibroblastoma-an-immunohistochemical-study-of-two-cases
#1
Masayuki Shintaku, Yoshihiro Yamamoto, Fumihiko Kono, Toshiyuki Kitai, Wakako Tsuji, Fumiaki Yotsumoto, Ryoji Kushima
Chondrolipoma of the breast is a very rare tumor whose histogenesis remains obscure. We report two cases (56-year-old and 43-year-old women) and present the results of an immunohistochemical study which strongly suggests that this tumor is a variant of myofibroblastoma. The tumors predominantly consisted of lipoma-like, mature adipose tissue, and many islands of hyaline cartilage. A proliferation of spindle cells associated with the deposition of collagen fibers was also seen. On immunohistochemical examination, spindle cells showed cytoplasmic reactivity for vimentin, desmin, bcl-2, and α-smooth muscle actin, as well as nuclear reactivity for estrogen receptor (ER) and progesterone receptor (PgR)...
June 26, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28649268/muscle-development-in-the-shark-scyliorhinus-canicula-implications-for-the-evolution-of-the-gnathostome-head-and-paired-appendage-musculature
#2
Janine M Ziermann, Renata Freitas, Rui Diogo
BACKGROUND: The origin of jawed vertebrates was marked by profound reconfigurations of the skeleton and muscles of the head and by the acquisition of two sets of paired appendages. Extant cartilaginous fish retained numerous plesiomorphic characters of jawed vertebrates, which include several aspects of their musculature. Therefore, myogenic studies on sharks are essential in yielding clues on the developmental processes involved in the origin of the muscular anatomy. RESULTS: Here we provide a detailed description of the development of specific muscular units integrating the cephalic and appendicular musculature of the shark model, Scyliorhinus canicula...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28649013/online-quantitative-monitoring-of-live-cell-engineered-cartilage-growth-using-diffuse-fiber-optic-raman-spectroscopy
#3
Mads S Bergholt, Michael B Albro, Molly M Stevens
Tissue engineering (TE) has the potential to improve the outcome for patients with osteoarthritis (OA). The successful clinical translation of this technique as part of a therapy requires the ability to measure extracellular matrix (ECM) production of engineered tissues in vitro, in order to ensure quality control and improve the likelihood of tissue survival upon implantation. Conventional techniques for assessing the ECM content of engineered cartilage, such as biochemical assays and histological staining are inherently destructive...
June 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28647600/the-in-vitro-biocompatibility-of-d-raffinose-modified-chitosan-two-dimensional-and-three-dimensional-systems-for-culturing-of-horse-articular-chondrocytes
#4
Elena De Angelis, Francesca Ravanetti, Paolo Martelli, Antonio Cacchioli, Ana Ivanovska, Attilio Corradi, Sonia Nasi, Annalisa Bianchera, Benedetta Passeri, Elena Canelli, Ruggero Bettini, Paolo Borghetti
The present study investigated the biocompatibility of chitosan films and scaffolds modified with d-(+)raffinose and their capability to support the growth and maintenance of the differentiation of articular chondrocytes in vitro. Primary equine articular chondrocytes were cultured on films and scaffolds of modified d-(+) raffinose chitosan. Their behavior was compared to that of chondrocytes grown in conventional bi- and three-dimensional culture systems, such as micromasses and alginate beads. Chitosan films maintained the phenotype of differentiated chondrocytes (typical round morphology) and sustained the synthesis of cartilaginous extracellular matrix (ECM), even at 4weeks of culture...
June 15, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28645676/a-journey-through-growth-plates-tracking-differences-in-morphology-and-regulation-between-the-spine-and-long-bones-in-a-pig-model
#5
Adalbert Raimann, Alireza Javanmardi, Monika Egerbacher, Gabriele Haeusler
BACKGROUND CONTEXT: The process of linear growth is driven by axial elongation of both long bones and vertebral bodies and accomplished by enchondral ossification. Differences in regulation between the two skeletal sites are mirrored clinically by the age course in body proportions. Whereas growth plates in long bones can easily be discriminated, vertebral growth plates are part of the cartilaginous endplate, which typically shows important species differences. PURPOSE: To describe and compare histological, histomorphometric and regulatory characteristics in the growth plates of the spine and long bones in a porcine model...
June 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28639070/osseous-cartilaginous-spreader-graft-and-nasal-framework-reconstruction
#6
Safvet Ors
Revision rhinoplasties and saddle nose deformities usually require grafting for reconstruction. Between January 1, 2000, and January 1, 2017, autologous rib grafts were used in 127 secondary and tertiary rhinoplasty patients [(57/127 females) and (70/127 males)]. Osseous-cartilaginous rib grafts (OCRGs) were divided into three parts (i.e., 1/3 upper peripheral, 1/3 central, and 1/3 lower peripheral). The harvested OCRGs were also shaped as vertical strips using a number 11 scalpel blade. These OCRGs were shaped to form the L-strut cartilaginous graft (LSCGs), osseous-cartilaginous spreader grafts (OCSGs), osseous-cartilaginous onlay grafts, nasal valve grafts (NVGs), and lower lateral cartilaginous grafts (LLCGs)...
June 21, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28634814/assessment-of-waterborne-amine-coated-silver-nanoparticle-ag-np-induced-toxicity-in-labeo-rohita-by-histological-and-hematological-profiles
#7
Muhammad Saleem Khan, Naureen Aziz Qureshi, Farhat Jabeen, Muhammad Shakeel, Muhammad Saleem Asghar
Silver nanoparticles (Ag-NPs) have wide applications in the medical field; however, the toxicological effects are still poorly studied. The study was aimed to determine the effects of 15.78 nm spherical and amine-coated Ag-NPs on hematology and histology of gills and liver tissues in 28 days treated Labeo rohita (L. rohita). It was found that Ag-NPs induced alterations in the hematological parameters in a dose dependent manner. The Ag-NPs also induced histological alterations in a dose-dependent manner. In gill tissues, it induced fusion of secondary lamellae, separation of gill epithelium, fusion and necrosis of lamellar cells, hyperplasia, deformed cartilaginous skeleton, separation and lifting of epithelium, and curling of lamellae in a dose dependent manner...
June 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28631675/-the-morphological-and-clinical-aspects-of-the-curvature-of-the-nasal-septum
#8
V N Krasnozhen, D A Shcherbakov, A V Volodeev, L A Musina, Yu A Garskova
The curvature of the nasal septum (NS) is one of the most widespread deformations of the facial skeleton. The objective of the present study was to substantiate the principles of and develop the rationale for the surgical correction and conservative treatment of this condition based on the morphological features of various types of deflection of the nasal septum. We have undertaken the morphological analysis of the osseous and cartilaginous structures determining the type and the shape of the curvature of the nasal septum together with the clinical analysis of different morphological variants of the deflection of the nasal septum making use of the R...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28630837/excision-of-solitary-osteochondroma-on-the-ventral-aspect-of-left-scapula-presenting-as-pseudowinging-in-a-4-year-old-boy-a-rare-case-report
#9
P Hegin Tungdim, I Ibomcha Singh, Sagnik Mukherjee, Tobu Pertin
INTRODUCTION: Osteochondroma is a benign bony lesion with cartilaginous cap occurring usually in long bones, but flat bones may also be involved, either isolated or as a part of a syndrome. Usually, they are asymptomatic, but appearance of symptoms such as mass effect may warrant surgical intervention, which is usually delayed till skeletal maturity. CASE REPORT: A 4-year-old male child presented with swelling on ventral aspect of inferior angle of scapula associated with pain, pseudowinging of scapula, and snapping sound of the left shoulder on movement...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630722/hip-arthroscopy-protocol-expert-opinions-on-post-operative-weight-bearing-and-return-to-sports-guidelines
#10
Ehud Rath, Zachary T Sharfman, Matan Paret, Eyal Amar, Michael Drexler, Nicolas Bonin
The objectives of this study are to survey the weight-bearing limitation practices and delay for returning to running and impact sports of high volume hip arthroscopy orthopedic surgeons. The study was designed in the form of expert survey questionnaire. Evidence-based data are scares regarding hip arthroscopy post-operative weight-bearing protocols. An international cross-sectional anonymous Internet survey of 26 high-volume hip arthroscopy specialized surgeons was conducted to report their weight-bearing limitations and rehabilitation protocols after various arthroscopic hip procedures...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28629737/the-obligatory-role-of-activin-a-in-the-formation-of-heterotopic-bone-in-fibrodysplasia-ossificans-progressiva
#11
Dana M Alessi Wolken, Vincent Idone, Sarah J Hatsell, Paul B Yu, Aris N Economides
Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder that presents at birth with only minor patterning defects, but manifests its debilitating pathology early in life with episodic, yet progressive and cumulative, heterotopic ossification (HO) of ligaments, tendons, and a subset of major skeletal muscles. The resulting HO lesions are endochondral in nature, and appear to be linked to inflammatory stimuli arising in association with known injuries, or from inflammation linked to normal tissue repair...
June 16, 2017: Bone
https://www.readbyqxmd.com/read/28628951/cranial-indicators-identified-for-peak-incidence-of-otitis-media
#12
Anthony Pagano, Eugene Wang, Derek Yuan, Daniel Fischer, Charles Bluestone, Samuel Marquez, Jeffrey Laitman
Acute otitis media (AOM) is one of the most common pediatric conditions worldwide. Peak age of occurrence for AOM has been identified within the first postnatal year and it remains frequent until approximately six postnatal years. Morphological differences between adults and infants in the cartilaginous Eustachian tube (CET) and associated structures may be responsible for development of this disease yet few have investigated normal growth trajectories. We tested hypotheses on coincidence of skeletal growth changes and known ages of peak AOM occurrence...
June 19, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28627740/biofabrication-of-soft-tissue-templates-for-engineering-the-bone-ligament-interface
#13
Ella Harris, Yurong Liu, Grainne Cuniffe, David Morrissey, Simon Carroll, Kevin Mulhall, Daniel J Kelly
Regenerating damaged tissue interfaces remains a significant clinical challenge, requiring recapitulation of the structure, composition and function of the native enthesis. In the ligament-to-bone interface this region transitions from ligament to fibrocartilage, to calcified cartilage and then to bone. This gradation in tissue types facilitates the transfer of load between soft and hard structures while minimizing stress concentrations at the interface. Previous attempts to engineer the ligament-bone interface have utilized various scaffold materials with an array of various cell types and/or biological cues...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28626128/a-case-of-matrix-producing-carcinoma-of-the-breast
#14
Yuzuru Inoue, Fumi Joden, Kei Yabuki, Nagahiro Sato, Noritaka Minagawa, Takefumi Katsuki, Norihiro Sato, Takahisa Nagata, Kazunori Shibao, Atsuji Matsuyama, Takatoshi Aoki, Keiji Hirata
A 61-year-old woman was referred to our hospital because of a right breast mass. A 19 mm hard mass was palpable in the A area of the right breast. A contrast-enhanced MRI showed rim enhancement at the peripheral region of the tumor, which was thought to represent the carcinoma component mainly at the periphery and the matrix component inside the tumor. A low density mass with rim enhancement at the peripheral region was observed in a contrast-enhanced CT, the same as in the MRI. Neither axillary lymph node metastasis nor distant metastasis was observed...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28624013/femoral-torsion-assessment-with-mri-in-children-should-we-use-the-bony-or-cartilaginous-contours
#15
Andrea B Rosskopf, Christoph A Agten, Leonhard E Ramseier, Christian W A Pfirrmann, Florian M Buck
OBJECTIVE: To assess whether the use of cartilaginous contours at the femoral condyles instead of bony contours significantly changes femoral torsion measurements in children. MATERIALS AND METHODS: Femoral torsion was measured in 32 girls (mean age 10.1 years±2.3 standard deviation) and 42 boys (10.9 years±2.5) on axial magnetic resonance (MR) images by two independent readers (R1,R2). The femoral condyle angle was measured using each the cartilaginous and bony contours of the distal femur...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28622746/sol-gel-derived-lithium-releasing-glass-for-cartilage-regeneration
#16
Siwei Li, Anthony Lb Maçon, Manon Jacquemin, Molly M Stevens, Julian R Jones
Wnt-signalling cascade is one of the crucial pathways involved in the development and homeostasis of cartilage. Influencing this pathway can potentially contribute to improved cartilage repair or regeneration. One key molecular regulator of the Wnt pathway is the glycogen synthase kinase-3 enzyme, the inhibition of which allows initiation of the signalling pathway. This study aims to utilise a binary SiO2-Li2O sol-gel derived glass for controlled delivery of lithium, a known glycogen synthase kinase-3 antagonist...
July 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28622604/tissue-engineered-hypertrophic-chondrocyte-grafts-enhanced-long-bone-repair
#17
Jonathan Bernhard, James Ferguson, Bernhard Rieder, Patrick Heimel, Thomas Nau, Stefan Tangl, Heinz Redl, Gordana Vunjak-Novakovic
Bone has innate ability to regenerate following injury. However, large and complex fractures exceed bone's natural repair capacity and result in non-unions, requiring external intervention to facilitate regeneration. One potential treatment solution, tissue-engineered bone grafts, has been dominated by recapitulating intramembranous ossification (bone formation by osteoblasts), although most serious bone injuries heal by endochondral ossification (bone formation by remodeling of hypertrophic cartilaginous anlage)...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28618871/five-year-follow-up-of-knee-joint-distraction-clinical-benefit-and-cartilaginous-tissue-repair-in-an-open-uncontrolled-prospective-study
#18
Jan-Ton A D van der Woude, Karen Wiegant, Peter M van Roermund, Femke Intema, Roel J H Custers, Felix Eckstein, Jaap M van Laar, Simon C Mastbergen, Floris P J G Lafeber
Objective In end-stage knee osteoarthritis, total knee arthroplasty (TKA) may finally become inevitable. At a relatively young age, this comes with the risk of future revision surgery. Therefore, in these cases, joint preserving surgery such as knee joint distraction (KJD) is preferred. Here we present 5-year follow-up data of KJD. Design Patients ( n = 20; age <60 years) with conservative therapy resistant tibiofemoral osteoarthritis considered for TKA were treated. Clinical evaluation was performed by questionnaires...
July 2017: Cartilage
https://www.readbyqxmd.com/read/28618041/effect-of-various-ratios-of-co-cultured-atdc5-cells-and-chondrocytes-on-the-expression-of-cartilaginous-phenotype-in-microcavitary-alginate-hydrogel
#19
Yongchang Yao, Yuyang Huang, Dongyang Qian, Shujiang Zhang, Yi Chen, Bo Bai
The present study introduced a direct co-culture of mouse ATDC5 cells and primary porcine chondrocytes into a microcavitary hydrogel, which possessed advantages in promoting the growth of chondrocytes and retaining the phenotype. These two types of cells were encapsulated with gelatin microspheres in alginate hydrogels in either of the three ratios (3:1, 1:1, or 1:3 of ATDC5 cells to chondrocytes) and cultured in chondrogenic medium for 28 days. Simultaneously, the single encapsulation of ATDC5 cells or chondrocytes was set as a control...
June 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28615116/an-unusual-presentation-of-synovial-chondromatosis-of-the-knee-in-a-10-year-old-girl
#20
Hyung Joon Cho, Jung Dong Suh
Synovial chondromatosis commonly occurs in the anterior compartment of the knee joint, predominantly in middle-aged men. It is relatively unusual in female children and is rarely encountered in the synovium beneath the meniscus. The present report describes a rare case of synovial chondromatosis that developed in the synovium just inferior to both menisci of the right knee in a 10-year-old girl. At this unusual age and location, there is a greater probability of missed diagnosis, due to the lack of definite informative incidence, and difficulty in finding the lesions during arthroscopic examinations...
June 11, 2017: Acta Orthopaedica et Traumatologica Turcica
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