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https://www.readbyqxmd.com/read/29238978/use-of-autologous-adipose-derived-mesenchymal-stem-cells-for-creation-of-laryngeal-cartilage
#1
Hongji Zhang, Sherry Voytik-Harbin, Sarah Brookes, Lujuan Zhang, Joseph Wallace, Noah Parker, Stacey Halum
OBJECTIVES/HYPOTHESIS: Adipose-derived mesenchymal stem cells (ASCs) are an exciting potential cell source for tissue engineering because cells can be derived from the simple excision of autologous fat. This study introduces a novel approach for tissue-engineering cartilage from ASCs and a customized collagen oligomer solution, and demonstrates that the resultant cartilage can be used for laryngeal cartilage reconstruction in an animal model. STUDY DESIGN: Basic science experimental design...
December 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29238686/mutilating-lesions-of-face
#2
Kavita Sachdeva, Aparaajita Upadhyay
The destructive lesions affect midline facial areas causing extensive destruction. These lesions are challenging till date due to peculiarity in presentation and non availability of any single objective test. An attempt has been done to evaluate these different clinical presentations of lesions presenting at a single centre and the challenges faced by us at a tertiary government setup. Prospective study done on 15 patients presenting in department during period of 2006-2016. After a detailed history, hematological and biochemical markers, ESR, radiographical tests, pus culture, C ANCA, CECT PNS and histopathogical evaluation were done...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29238440/osteochondrolipoma-of-the-mandible
#3
Takeshi Kitazawa, Masato Shiba
Objective: Lipomas are very common benign tumors located in any part of the body in which fat is normally present, but lipomas containing both osseous and cartilaginous elements are rare. Methods: A case of osteochondrolipoma in a 72-year-old man is reported. The tumor in the mental region was 2×1.5×1.5 cm. Results: After resection of the tumor, there has been no recurrence during the 6-month postoperative follow-up. Histological examination confirmed the definitive diagnosis. Conclusions: Osteochondrolipoma is an extremely unusual lesion that should be kept in mind in the differential diagnosis of soft-tissue tumors...
2017: Eplasty
https://www.readbyqxmd.com/read/29237492/pentosan-polysulfate-binds-to-stro-1-mesenchymal-progenitor-cells-is-internalized-and-modifies-gene-expression-a-novel-approach-of-pre-programing-stem-cells-for-therapeutic-application-requiring-their-chondrogenesis
#4
Jiehua Wu, Susan Shimmon, Sharon Paton, Christopher Daly, Tony Goldschlager, Stan Gronthos, Andrew C W Zannettino, Peter Ghosh
BACKGROUND: The pharmaceutical agent pentosan polysulfate (PPS) is known to induce proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in vivo. However, the mechanism(s) of action of PPS in mediating these effects remains unresolved. In the present report we address this issue by investigating the binding and uptake of PPS by MPCs and monitoring gene expression and proteoglycan biosynthesis before and after the cells had been exposed to limited concentrations of PPS and then re-established in culture in the absence of the drug (MPC priming)...
December 13, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29236544/gene-therapy-for-cystic-fibrosis-improved-delivery-techniques-and-conditioning-with-lysophosphatidylcholine-enhance-lentiviral-gene-transfer-in-mouse-lung-airways
#5
Patricia Cmielewski, Nigel Farrow, Sharnna Devereux, David Parsons, Martin Donnelley
Purpose/Aim: Cystic fibrosis (CF) is the most common, fatal recessive genetic disease among the Caucasian population. Gene therapy has the potential to treat CF long term, however physiological barriers can prevent VSV-G pseudotyped lentiviral (LV) vectors from efficiently accessing the relevant receptors on the basolateral membrane of airway epithelial cells. The aims of this experiment were to use our new dose delivery techniques to determine whether conditioning the mouse lung conducting airways with lysophosphatidylcholine (LPC) improves the level of airway gene expression...
December 13, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29232670/some-galeomorph-sharks-express-a-mammalian-microglia-specific-protein-in-radial-ependymoglia-of-the-telencephalon
#6
Skirmantas Janušonis
Ionized calcium-binding adapter molecule 1 (Iba1), also known as allograft inflammatory factor 1 (AIF-1), is a highly conserved cytoplasmic scaffold protein. Studies strongly suggest that Iba1 is associated with immune-like reactions in all Metazoa. In the mammalian brain, it is abundantly expressed in microglial cells and is used as a reliable marker for this cell type. The present study used multiple-label microscopy and Western blotting to examine Iba1 expression in the telencephalon of 2 galeomorph shark species, the swellshark (Cephaloscyllium ventriosum) and the horn shark (Heterodontus francisci), a member of an ancient extant order...
December 13, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/29229399/the-malleus-cap-anatomic-description-of-cartilage-of-the-lateral-process-of-the-malleus
#7
Elias Michaelides, Ankit Kansal, Sara Rutter, Christopher A Schutt
PURPOSE: To anatomically describe a cartilaginous cap attached to the lateral process of the malleus. STUDY DESIGN: Histologic and gross anatomic review. METHODS: Twenty temporal bones were histologically reviewed. The anatomical relationship between the tympanic membrane and malleus was then defined at the level of the lateral process of the malleus and the long process of the malleus. Separately, gross evaluation of these levels at the macroscopic level was undertaken through endoscopic imaging in five subjects...
October 25, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29219024/excess-maternal-thyroxine-alters-the-proliferative-activity-and-angiogenic-profile-of-growth-cartilage-of-rats-at-birth-and-weaning
#8
Lorena Gabriela Rocha Ribeiro, Juneo Freitas Silva, Natália de Melo Ocarino, Cíntia Almeida de Souza, Eliane Gonçalves de Melo, Rogéria Serakides
Objective The aim of this study was to unravel the mechanisms by which thyroxine affects skeletal growth by evaluating proliferative activity and angiogenic profile of growth cartilage of neonatal and weanling rats. Methods Sixteen adult Wistar rats were equally divided into 2 groups: control and treated with thyroxine during pregnancy and lactation. The weight, measurement of plasma free T4 and thyroids, femurs' histomorphometric analysis, and proliferative activity and angiogenic profile by immunohistochemical or real-time reverse transcriptase-polymerase chain reaction in growth cartilage was performed...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29214370/lumbar-intervertebral-disc-allograft-transplantation-the-revascularisation-pattern
#9
Yong-Can Huang, Jun Xiao, Victor Y Leung, William W Lu, Yong Hu, Keith D K Luk
PURPOSE: Fresh frozen intervertebral disc allograft transplantation has been reported to be a viable treatment option for advanced degenerative disc diseases, but rapid degeneration of the postoperative allograft was found. Loss of nutrient supply is believed to be the most likely inducer because the disc allografts have to endure in an ischaemic environment until the nutrient pathway is re-established. The aim of this study was to focus on the revascularisation of the disc allograft after transplantation in goats...
December 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29205898/effects-of-oral-glucosamine-hydrochloride-and-mucopolysaccharide-protein-in-a-rabbit-model-of-osteoarthritis
#10
Da-Hee Jeong, H M Arif Ullah, Moon-Jung Goo, Soong-Gu Ghim, Il-Hwa Hong, Ah-Young Kim, Sun-Min Jeon, Myung-Sook Choi, Ahmed K Elfadl, Myung-Jin Chung, Eun-Joo Lee, Yong D Kim, Jun-Hyung Kim, Shin-Yoon Kim, Kyu-Shik Jeong
AIM: The aim was to study whether oral glucosamine hydrochloride (GlcN.HCl) or mucopolysaccharide protein (MucoP) has a structure-modifying effect on an anterior cruciate ligament transection (ACLT) rabbit model of osteoarthritis (OA). METHODS: OA was surgically induced in the right knees of rabbits by transection of the ACLT. The left knees served as a sham-operated control. The animals were divided into four groups (n = 6 each): negative control (phosphate buffered saline, orally), positive control (oral celecoxib 10 mg/kg body weight/day), GlcN...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29202349/chondrometaplasia-of-the-vocal-cord-in-an-adult-male
#11
Hamoud Al Arouj, Abdulmohsen Kamel AlBader, Imtiyaz Nawaz Bhat
INTRODUCTION: (Chondrometaplasia of the larynx is a rare disease. We report a case that presented at the otolaryngology department in our institute in 2015.) PRESENTATION OF CASE: A 62year old man without any history of trauma presented with progressive dysphonia, dyspnoea, without any dysphagia. A fibreoptic laryngoscopic examination revealed nodular mass arising at the junction of anterior 1/3rd and posterior 2/3rd of left vocal cord. DISCUSSION: A computed tomography scan of the neck region showed a rounded and circumscribed mass without infiltration of the surrounding tissues...
November 22, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29197957/magnetic-resonance-imaging-follow-up-of-chondroid-tumors-regression-vs-progression
#12
Bo Mi Chung, Sung Hwan Hong, Hye Jin Yoo, Ja-Young Choi, Hee-Dong Chae, Dong Hyun Kim
OBJECTIVE: To present magnetic resonance imaging (MRI) evidence of the regression or progression of chondroid tumors and to investigate whether MRI can be used to predict the evolution of chondroid tumors. MATERIALS AND METHODS: Twenty-one patients with enchondromas or atypical cartilaginous tumors who had undergone extremity MRI at least twice with a minimum 12-month interval between the MRIs were enrolled in this study. The diagnosis was based on the radiography and MRI findings...
December 3, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29194731/human-mesenchymal-stem-cells-induced-to-differentiate-as-chondrocytes-follow-a-biphasic-pattern-of-extracellular-matrix-production
#13
J Michael Sorrell, Rodrigo A Somoza, Arnold I Caplan
Regenerative medicine and tissue engineering studies are actively developing novel means to repair adult articular cartilage defects using biological approaches. One such approach is the harnessing of adult human therapeutic cells such as those referred to as mesenchymal stem cells. Upon exposure to chondrogenic signals, these cells differentiate and initiate the production of a complex and voluminous cartilaginous matrix that is crucial to both the structure and function of cartilage. Furthermore, this complexity requires the time-sensitive activation of a large number of genes to produce the components of this matrix...
November 30, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29190650/reduced-bone-length-growth-plate-thickness-bone-content-and-igf-i-as-a-model-for-poor-growth-in-the-cftr-deficient-rat
#14
Michael S Stalvey, Viktoria Havasi, Katherine L Tuggle, Dezhi Wang, Susan Birket, Steve M Rowe, Eric J Sorscher
BACKGROUND: Reduced growth and osteopenia are common in individuals with cystic fibrosis (CF). Additionally, improved weight and height are associated with better lung function and overall health in the disease. Mechanisms for this reduction in growth are not understood. We utilized a new CFTR knockout rat to evaluate growth in young CF animals, via femur length, microarchitecture of bone and growth plate, as well as serum IGF-I concentrations. METHODS: Femur length was measured in wild-type (WT) and SD-CFTRtm1sage (Cftr-/-) rats, as a surrogate marker for growth...
2017: PloS One
https://www.readbyqxmd.com/read/29187087/heart-transplantation-as-last-resort-treatment-for-relapsing-polychondritis-with-severe-cardiac-involvement
#15
Laurent Dormoy, Annette Belin, Fabien Labombarda
Relapsing polychondritis is a rare multisystem autoimmune disease characterized by recurrent inflammation and destruction of different cartilaginous and proteoglycan-rich structures like cardiovascular system. We reported a case of heart transplantation in a 20-year-old man having a relapsing polychondritis with severe multiple cardiovascular involvement. The immunosuppressive treatment used to prevent graft rejection allowed to turn out the inflammatory disease. Cardiac transplantation may be considered as last resort treatment option in relapsing polychondritis with intractable extensive heart lesions...
September 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29181348/focal-periphyseal-edema-zone-on-magnetic-resonance-imaging-in-the-greater-trochanter-apophysis-a-case-report
#16
Akio Sakamoto, Shuichi Matsuda
Introduction: Magnetic resonance imaging (MRI) has been used to identify focal bone marrow edema or a focal periphyseal edema (FOPE) zone, in the closing growth plates of adolescent knees. Case Report: In the current case, an 11-year-old boy reported pain in his left hip. He had been participating in gymnastic classes at school, but otherwise, he was not an active athlete. Based on MRI findings, he was diagnosed with a FOPE zone in his greater trochanteric apophysis...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29181103/myxoid-liposarcoma-with-cartilaginous-differentiation-showing-ddit3-rearrangement
#17
Kayo Suzuki, Taketoshi Yasuda, Kenta Watanabe, Takeshi Hori, Masahiko Kanamori, Tomoatsu Kimura
Myxoid liposarcoma (MLPS) is the second most common histologic subtype of liposarcoma. However, cartilaginous differentiation within MLPS is an extremely rare phenomenon, with only 7 cases of MLPS with cartilaginous differentiation reported to date. The majority of MLPS cases show the t(12;16)(q13;p11) translocation, resulting in the fused in sarcoma-DNA damage-inducible transcript 3 (FUS-DDIT3) fusion gene. This fusion gene as a hallmark of MLPS is very useful for differential diagnosis from other soft tissue sarcomas, and the associated protein, FUS-DDIT3, performs an important role in the phenotypic selection of targeted multipotent mesenchymal cells during oncogenesis...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29169959/chondrogenic-potential-of-il-10-in-mechanically-injured-cartilage-and-cellularized-collagen-aci-grafts
#18
P Behrendt, M Feldheim, A Preusse-Prange, J T Weitkamp, M Haake, D Eglin, B Rolauffs, J Fay, A Seekamp, A J Grodzinsky, B Kurz
OBJECTIVE: The application of adjunctive mediators in ACI techniques might be useful for improving the dedifferentiated chondrocyte phenotype, to support neocartilage formation and inhibit post-traumatic cartilage destruction. In this study we examined if (a) interleukin 10 treatment can cause chondrogenic phenotype stabilization and matrix preservation in mechanically injured cartilage and if (b) IL-10 can promote chondrogenesis in a clinically applied collagen scaffold for ACI treatment...
November 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29167367/embryonic-origin-of-the-gnathostome-vertebral-skeleton
#19
Katharine E Criswell, Michael I Coates, J Andrew Gillis
The vertebral column is a key component of the jawed vertebrate (gnathostome) body plan, but the primitive embryonic origin of this skeleton remains unclear. In tetrapods, all vertebral components (neural arches, haemal arches and centra) derive from paraxial mesoderm (somites). However, in teleost fishes, vertebrae have a dual embryonic origin, with arches derived from somites, but centra formed, in part, by secretion of bone matrix from the notochord. Here, we test the embryonic origin of the vertebral skeleton in a cartilaginous fish (the skate, Leucoraja erinacea) which serves as an outgroup to tetrapods and teleosts...
November 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29167068/three-dimensional-morphology-of-lunate-surface-in-hip-dysplasia-theoretical-implications-for-periacetabular-osteotomy
#20
Meng Xu, Yanbing Wang, Lei Zhong, Yang Song, Jianlin Xiao, Yu Sun, Wei Li, Zhe Zhu, Xin Zhao, Jincheng Wang
BACKGROUND: The objective of this study was to evaluate three-dimensional morphology of acetabular lunate surface in patients with dysplastic hip using three-dimensional computed tomography (CT), and to compare the lunate surface morphology between the normal and dysplastic hips. METHODS: Sixty seven dysplastic hips in symptomatic patients and 61 normal hips in healthy volunteers who underwent three-dimensional CT scanning were included in this study. The size and shape of the lunate surface was measured with a fully automated imaging technique using Mimics16...
November 19, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
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