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https://www.readbyqxmd.com/read/28226370/osseous-and-cartilaginous-nasal-reconstruction
#1
Samuel Hahn
The nose is a complex, three-dimensional structure that is supported by a framework of osseous and cartilaginous structures. Disruption of this framework can result in nasal deformity and functional deficits. Nasal reconstruction requires restoration of the osseous and cartilaginous framework. This requires careful preoperative assessment of the nasal defect and understanding the nasal and facial aesthetics that are supported by the osseous and cartilaginous support structures. Structural grafts can be classified as restorative, supportive, or contouring...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28214875/a-developmental-study-of-the-cerebellar-nucleus-in-the-catshark-a-basal-gnathostome
#2
Sol Pose-Méndez, Isabel Rodríguez-Moldes, Eva Candal, Sylvie Mazan, Ramón Anadón
The output of the cerebellar cortex is mainly released via cerebellar nuclei which vary in number and complexity among gnathostomes, extant vertebrates with a cerebellum. Cartilaginous fishes, a basal gnathostome lineage, show a conspicuous, well-organized cerebellar nucleus, unlike ray-finned fishes. To gain insight into the evolution and development of the cerebellar nucleus, we analyzed in the shark Scyliorhinus canicula (a chondrichthyan model species) the developmental expression of several genes coding for transcription factors (ScLhx5,ScLhx9,ScTbr1, and ScEn2) and the distribution of the protein calbindin, since all appear to be involved in cerebellar nuclei patterning in other gnathostomes...
February 18, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28212333/the%C3%A2-cardiovascular%C3%A2-and%C3%A2-neurotoxic%C3%A2-effects%C3%A2-of%C3%A2-the%C3%A2-venoms%C3%A2-of%C3%A2-six%C3%A2-bony%C3%A2-and%C3%A2-cartilaginous%C3%A2-fish%C3%A2-species
#3
Han Han, Kate Baumann, Nicholas R Casewell, Syed A Ali, James Dobson, Ivan Koludarov, Jordan Debono, Scott C Cutmore, Niwanthi W Rajapakse, Timothy N W Jackson, Rob Jones, Wayne C Hodgson, Bryan G Fry, Sanjaya Kuruppu
Fish venoms are often poorly studied, in part due to the difficulty in obtaining, extracting, and storing them. In this study, we characterize the cardiovascular and neurotoxic effects of the venoms from the following six species of fish: the cartilaginous stingrays Neotrygon kuhlii and Himantura toshi, and the bony fish Platycephalus fucus, Girella tricuspidata, Mugil cephalus, and Dentex tumifrons. All venoms (10-100 μg/kg, i.v.), except G. tricuspidata and P. fuscus, induced a biphasic response on mean arterial pressure (MAP) in the anesthetised rat...
February 16, 2017: Toxins
https://www.readbyqxmd.com/read/28210944/postoperative-imaging-in-arthroscopic-hip-surgery
#4
REVIEW
F Di Pietto, V Chianca, R de Ritis, E Cesarano, A Reginelli, A Barile, M Zappia, L Ginolfi
Arthroscopic surgery of the hip, compared to that of the knee or the shoulder, has only recently been developed in any significant way. Current indications for arthroscopic surgery of the hip include: diagnosis and treatment of lesions symptomatic of the acetabular labrum, femoroacetabular impingement (FAI), chondral lesions, joint infections, lesions of the teres ligament, impingement of the psoas tendon, pathology of the peritrochanteric space, external snapping hip (coxa saltans), and traumatic and atraumatic instability...
February 16, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28209412/injectable-chondroplasty-enzymatic-reshaping-of-cartilage-grafts
#5
J R Gandy, A Foulad, K K Chao, B J F Wong
OBJECTIVE/HYPOTHESIS: To develop an injection-based enzymatic technique that selectively softens cartilage tissue for reshaping cartilaginous structures in the head and neck. MATERIALS AND METHODS: Two groups were formed using fresh rabbit ears: (1) whole rabbit ear group; (2) composite graft group (2.5mm×3.0cm specimens sectioned from the central region of the pinna). Subperichondrial injections using three enzymes (hyaluronidase, pronase, and collagenase II) in sequence were performed for the experimental specimens from both groups...
February 10, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28207003/relapsing-polychondritis-with-meningoencephalitis
#6
Monica Tsai, Mengjun Hu, Jamie Zussman, Scott Worswick
Relapsing polychondritis (RP) is a rare autoimmune disease of the cartilaginous structures of the body with many systemic manifestations including meningoencephalitis (ME). We present a case of a man with RP-associated ME that was responsive to steroid treatment. An updated literature review of 7 cases of RP-associated ME also is provided. Early diagnosis of this condition may be of benefit to this select population of patients, and further research regarding the prognosis, mechanisms, and treatment of RP may be necessary in the future...
January 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28205076/do-orthopaedic-oncologists-agree-on-the-diagnosis-and-treatment-of-cartilage-tumors-of-the-appendicular-skeleton
#7
Tomas Zamora, Julio Urrutia, Daniel Schweitzer, Pedro Pablo Amenabar, Eduardo Botello
BACKGROUND: Distinguishing a benign enchondroma from a low-grade chondrosarcoma is a common diagnostic challenge for orthopaedic oncologists. Low interrater agreement has been observed for the diagnosis of cartilaginous neoplasms among radiologists and pathologists, but, to our knowledge, no study has evaluated inter- and intraobserver agreement among orthopaedic oncologists grading these lesions using initial clinical and imaging information. Determining such agreement is important since it reflects the certainty in the diagnosis by orthopaedic oncologists...
February 15, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28194374/regenerative-potential-of-the-cartilaginous-tissue-in-mesenchymal-stem-cells-update-limitations-and-challenges
#8
Ivana Beatrice Mânica da Cruz, Antônio Lourenço Severo, Verônica Farina Azzolin, Luiz Filipe Machado Garcia, André Kuhn, Osvandré Lech
Advances in the studies with adult mesenchymal stem cells (MSCs) have turned tissue regenerative therapy into a promising tool in many areas of medicine. In orthopedics, one of the main challenges has been the regeneration of cartilage tissue, mainly in diarthroses. In the induction of the MSCs, in addition to cytodifferentiation, the microenvironmental context of the tissue to be regenerated and an appropriate spatial arrangement are extremely important factors. Furthermore, it is known that MSC differentiation is fundamentally determined by mechanisms such as cell proliferation (mitosis), biochemical-molecular interactions, movement, cell adhesion, and apoptosis...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28193015/derivatization-strategies-for-the-detection-of-triamcinolone-acetonide-in-cartilage-by-using-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging
#9
Florian P Y Barré, Bryn Flinders, João P Garcia, Imke Jansen, Lennart R S Huizing, Tiffany Porta, Laura B Creemers, Ron M A Heeren, Berta Cillero-Pastor
Osteoarthritis (OA), characterized by degeneration of the cartilaginous tissue in articular joints, severely impairs mobility in many people worldwide. The degeneration is thought to be mediated by inflammatory processes occurring in the tissue of the joint, including the cartilage. Intra-articular administered triamcinolone acetonide (TAA) is one of the drug treatments employed to ameliorate the inflammation and pain that characterizes OA. However, the penetration and distribution of TAA into the avascular cartilage is not well understood...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28191465/pedf-is-associated-with-the-termination-of-chondrocyte-phenotype-and-catabolism-of-cartilage-tissue
#10
P Klinger, S Lukassen, F Ferrazzi, A B Ekici, T Hotfiel, B Swoboda, T Aigner, K Gelse
Objective. To investigate the expression and target genes of pigment epithelium-derived factor (PEDF) in cartilage and chondrocytes, respectively. Methods. We analyzed the expression pattern of PEDF in different human cartilaginous tissues including articular cartilage, osteophytic cartilage, and fetal epiphyseal and growth plate cartilage, by immunohistochemistry and quantitative real-time (qRT) PCR. Transcriptome analysis after stimulation of human articular chondrocytes with rhPEDF was performed by RNA sequencing (RNA-Seq) and confirmed by qRT-PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28190727/the-origin-of-vertebrate-gills
#11
J Andrew Gillis, Olivia R A Tidswell
Pharyngeal gills are a fundamental feature of the vertebrate body plan [1]. However, the evolutionary history of vertebrate gills has been the subject of a long-standing controversy [2-8]. It is thought that gills evolved independently in cyclostomes (jawless vertebrates-lampreys and hagfish) and gnathostomes (jawed vertebrates-cartilaginous and bony fishes), based on their distinct embryonic origins: the gills of cyclostomes derive from endoderm [9-12], while gnathostome gills were classically thought to derive from ectoderm [10, 13]...
February 3, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28177645/conventional-radiographs-and-magnetic-resonance-imaging-for-the-analysis-of-trochlear-dysplasia
#12
Philippe Matthias Tscholl, Florian Wanivenhaus, Sandro F Fucentese
BACKGROUND: Trochlear dysplasia is one of the most important risk factors for recurrent patellar instability. It is defined on true lateral conventional radiographs (CR) and axial magnetic resonance imaging (MRI). The type of trochlear dysplasia is decisive for surgical treatment; however, low agreement between CR and MRI has been reported. PURPOSE: To compare the Dejour classification of trochlear dysplasia on CR and axial MRI using differing levels defined in the literature...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28167429/the-relationship-between-the-distal-metatarsal-articular-angle-and-intersesamoidal-crista-an-osteological-study
#13
Megan Maddocks, Shahed Nalla, Bernhard Zipfel
BACKGROUND: As hallux valgus (HV) progresses, the first metatarsal drifts medially and the subsequent lateral drift of the sesamoids results in intersesamoidal crista erosion. This study aimed to provide a novel method of assessing crista erosion and determine if there is a relationship between that erosion and an increase in the distal metatarsal articular angle (DMAA). METHODS: The DMAA and size of the intersesamoidal crista was measured on the first metatarsals of 120 adult modern human individuals...
January 17, 2017: Foot
https://www.readbyqxmd.com/read/28166705/high-tibial-osteotomy-combined-with-cancellous-bone-graft-and-osteochondral-autograft-transplantation-in-a-patient-with-massive-osteochondral-defects-in-the-medial-femoral-condyle
#14
Takehiko Matsushita, Shu Watanabe, Daisuke Araki, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda
Treatment of massive osteochondral defects of the medial femoral condyle is challenging. A 46-year-old man who had a medial femoral condyle fracture on his left knee underwent osteosynthesis in a hospital, but the pain remained and the patient was referred to our hospital 8 months after the surgery. Radiographs showed a varus alignment of the leg, and magnetic resonance image showed a massive necrotic area in the medial femoral condyle. The patient received high tibial osteotomy (HTO) combined with iliac cancellous bone graft and an osteochondral autograft transplantation...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28166636/cartilaginous-metabolomic-study-reveals-potential-mechanisms-of-osteophyte-formation-in-osteoarthritis
#15
Zhongwei Xu, Tingmei Chen, Jiao Luo, Shijia Ding, Sichuan Gao, Jian Zhang
Osteophyte is one of the inevitable consequences of progressive osteoarthritis with the main characteristics of cartilage degeneration and endochondral ossification. The pathogenesis of osteophyte formation is not fully understood to date. In this work, metabolomic approaches were employed to explore potential mechanisms of osteophyte formation by detecting metabolic variations between extracts of osteophyte cartilage tissues (n = 32) and uninvolved control cartilage tissues (n = 34), based on the platform of ultraperformance liquid chromatography tandem quadrupole time-of-flight mass spectrometry, as well as the use of multivariate statistic analysis and univariate statistic analysis...
February 21, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28155855/evolution-of-shh-endoderm-enhancers-during-morphological-transition-from-ventral-lungs-to-dorsal-gas-bladder
#16
Tomoko Sagai, Takanori Amano, Akiteru Maeno, Tetsuaki Kimura, Masatoshi Nakamoto, Yusuke Takehana, Kiyoshi Naruse, Norihiro Okada, Hiroshi Kiyonari, Toshihiko Shiroishi
Shh signalling plays a crucial role for endoderm development. A Shh endoderm enhancer, MACS1, is well conserved across terrestrial animals with lungs. Here, we first show that eliminating mouse MACS1 causes severe defects in laryngeal development, indicating that MACS1-directed Shh signalling is indispensable for respiratory organogenesis. Extensive phylogenetic analyses revealed that MACS1 emerged prior to the divergence of cartilaginous and bony fishes, and even euteleost fishes have a MACS1 orthologue. Meanwhile, ray-finned fishes evolved a novel conserved non-coding sequence in the neighbouring region...
February 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28148266/restoration-of-a-large-osteochondral-defect-of-the-knee-using-a-composite-of-umbilical-cord-blood-derived-mesenchymal-stem-cells-and-hyaluronic-acid-hydrogel-a-case-report-with-a-5-year-follow-up
#17
Yong-Beom Park, Chul-Won Ha, Choong-Hee Lee, Yong-Geun Park
BACKGROUND: The treatment of articular cartilage defects is a therapeutic challenge for orthopaedic surgeons. Furthermore, large osteochondral defects needs restoration of the underlying bone for sufficient biomechanical characteristics as well as the overlying cartilage. CASE PRESENTATION: A symptomatic large osteochondral defect in the knee joint was restored using a composite of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) 0.5 x 10(7)/ml and 4% hyaluronic acid (HA) hydrogel...
February 2, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28144734/rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif
#18
Kenichiro Kita, Toshinori Sakai, Mitsunobu Abe, Yoichiro Takata, Koichi Sairyo
Lumbar intervertebral disc degeneration (LDD) is known to be associated with low back pain (LBP) and leads to degenerative lumbar disease. LDD is considered to be irreversible, and no truly effective treatment that suppresses LDD or regenerates the degenerated disc has been established thus far. Here, we report the case of a 42-year-old woman with a 10-year history of persistent LBP. Magnetic resonance imaging (MRI) demonstrated degenerative changes (Pfirrmann classification: grade IV) in the L4-5 intervertebral disc with type I and III mixed Modic changes adjacent to the disc...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28144062/role-of-radial-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-the-diagnosis-of-pulmonary-nodules-case-report-and-literature-review
#19
Sahajal Dhooria, Inderpaul Singh Sehgal, Nalini Gupta, Ashutosh Nath Aggarwal, Digambar Behera, Ritesh Agarwal
The diagnosis of pulmonary nodules can be made using several methods including computed tomography (CT)-guided fine-needle aspiration (FNA), radial endobronchial ultrasound (EBUS)-guided sampling techniques (transbronchial lung biopsy [TBLB], transbronchial brush, bronchoalveolar lavage, or transbronchial needle aspiration [TBNA]), or occasionally with convex probe (CP) EBUS-TBNA. While CT-guided FNA is associated with a high (25%) rate of pneumothorax, the CP-EBUS cannot reach lesions beyond the interlobar region...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28141652/tracheal-cartilaginous-sleeve-in-syndromic-craniosynostosis-an-underrecognized-source-of-significant-morbidity-and-mortality
#20
Brent B Pickrell, Jesse D Meaike, Karina T Cañadas, Binoy M Chandy, Edward P Buchanan
Tracheal cartilaginous sleeve (TCS) is a rare and previously unrecognized source of morbidity and mortality in patients with certain craniosynostosis syndromes. There is a paucity of reporting on this airway anomaly, and the true incidence of TCS is largely unknown. The purpose of this study was to investigate the incidence of TCS among patients with syndromic craniosynostosis at our institution. Patients with syndromic craniosynostosis who underwent direct bronchoscopy and laryngoscopy were evaluated retrospectively by pediatric otolaryngologists for the presence of TCS and associated anomalies...
January 30, 2017: Journal of Craniofacial Surgery
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