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https://www.readbyqxmd.com/read/29471601/-bladder-rupture-during-intravesical-bcg-therapy-a-case-report
#1
Yusuke Iemura, Shinji Fukui, Yoshiaki Matsumura, Yoriaki Kagebayashi, Yuta Toyoshima, Takeshi Inoue, Shoji Samma
A 69-year-old man received transurethral resection (TUR) ofbladder tumor. The histopathological diagnosis was urothelial carcinoma, high grade, pT1+pTis. The surgical specimens obtained by second TUR showed no residual malignancy histopathologically. Intravesical Bacillus Calmette-Guerin (BCG) instillation therapy was initiated 2 months after the second TUR. He complained of lower abdominal pain and painful urination on the day following the second instillation of BCG. Computed tomography and cystography demonstrated rupture ofthe urinary bladder...
January 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29471148/photonic-technology-for-the-treatments-of-the-venous-and-arterial-ulcers-case-report
#2
Fernanda Mansano Carbinatto, Antonio Eduardo de Aquino, Vitória Helena Maciel Coelho, Vanderlei S Bagnato
In this report, we recent a case study on a 50-year-old male patient with different chronic wounds, such as venous ulcer and arterial ulcer in both legs. These wounds have persisted for more than 10 years, despite the different treatments applied, between safenectomy, different dressings, hyperbaric camera, as well as the used of several medicines of oral and topical application. The case is addressed with the aim to evaluate if treatment that uses combined techniques such as low level laser therapy (LLLT), photodynamic therapy and cellulose membrane is able to improve healing and reduction of time of treatment in those types of chronic wounds...
February 19, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29468490/negative-pressure-wound-therapy-reduces-the-motility-of-pseudomonas-aeruginosa-and-enhances-wound-healing-in-a-rabbit-ear-biofilm-infection-model
#3
Wang Guoqi, Li Zhirui, Wang Song, Li Tongtong, Zhang Lihai, Zhang Licheng, Tang Peifu
Pseudomonas aeruginosa motility, virulence factors and biofilms are known to be detrimental to wound healing. The efficacy of negative pressure wound therapy (NPWT) against P. aeruginosa has been little studied, either in vitro or in vivo. The present study evaluated the effect of negative pressure (NP) on P. aeruginosa motility in vitro, and the effect of NPWT on virulence factors and biofilms in vivo. P. aeruginosa motility was quantified under different levels of NP (atmospheric pressure, - 75, - 125, - 200 mmHg) using an in vitro model...
February 21, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29467483/clove-bud-oil-modulates-pathogenicity-phenotypes-of-the-opportunistic-human-pathogen-pseudomonas-aeruginosa
#4
Jayalekshmi Haripriyan, Athira Omanakuttan, Nitasha D Menon, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Ross Corriden, Bipin G Nair, Victor Nizet, Geetha B Kumar
Earlier studies from our laboratory have demonstrated that clove bud oil (CBO) attenuates expression of certain virulence factors of Pseudomonas aeruginosa PAO1. Here, we probe more deeply into the effect of CBO on four pseudomonal proteases - elastase A, elastase B, protease IV and alkaline protease - each known to play key roles in disease pathogenesis. CBO inhibited the activity of these proteases present in the bacterial culture supernatant. Zymography studies indicated that these proteases can activate host matrix metalloproteases (MMPs) to establish infection, through conversion of pro-MMP-2 to active MMP-2...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467441/linc01016-promotes-the-malignant-phenotype-of-endometrial-cancer-cells-by-regulating-the-mir-302a-3p-mir-3130-3p-nfya-satb1-axis
#5
Xin Pan, Da Li, Jianing Huo, Fanfei Kong, Hui Yang, Xiaoxin Ma
Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis and cancer progression and are tightly associated with the phenotypes of numerous cancers. However, the functional roles underlying these effects are unknown. The expression levels of LINC01016, miR-302a-3p, miR-3130-3p, NFYA, and SATB1 were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) in 33 endometrial cancer tissues and 20 normal tissues. Bioinformatics analyses, luciferase reporter analyses, chromatin immunoprecipitation (ChIP) assays, and qRT-PCR assays were performed to verify potential binding sites...
February 21, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29466934/thirty-six-month-outcomes-of-drug-eluting-balloon-angioplasty-in-the-infrapopliteal-arteries
#6
Berkan Ozpak, Sahin Bozok, Mustafa Cagdas Cayir
Objectives To evaluate 36-month outcomes of drug-eluting balloons in infrapopliteal (=below-the-knee) arterial segments, we made a prospective registry enrolling patients (Rutherford class 2 to 5, ankle-brachial index 0.4-0.7) who were revascularized with drug-eluting balloon from August 2011 to December 2014. Methods Three hundred and seven infrapopliteal arteries were revascularized only with drug-eluting balloon. Endpoints included target lesion revascularization, primary patency rate, and changes in ankle-brachial index and Rutherford class...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29464859/growth-hormone-releasing-peptide-6-prevents-cutaneous-hypertrophic-scarring-early-mechanistic-data-from-a-proteome-study
#7
Maday Fernández-Mayola, Lázaro Betancourt, Alicia Molina-Kautzman, Sucel Palomares, Yssel Mendoza-Marí, Dayana Ugarte-Moreno, Ana Aguilera-Barreto, Yilian Bermúdez-Álvarez, Vladimir Besada, Luis J González, Ariana García-Ojalvo, Ana J Mir-Benítez, Aleida Urquiza-Rodríguez, Jorge Berlanga-Acosta
Hypertrophic scars (HTS) and keloids are forms of aberrant cutaneous healing with excessive extracellular matrix (ECM) deposition. Current therapies still fall short and cause undesired effects. We aimed to thoroughly evaluate the ability of growth hormone releasing peptide 6 (GHRP6) to both prevent and reverse cutaneous fibrosis and to acquire the earliest proteome data supporting GHRP6's acute impact on aesthetic wound healing. Two independent sets of experiments addressing prevention and reversion effects were conducted on the classic HTS model in rabbits...
February 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29464230/the-australian-mid-west-coastal-marine-wound-infections-study
#8
Andy Foote, Robert Henderson, Andrew Lindberg, Carolyn Grigg, Charlie Greenfield, Andrew B Kirke, Kirsten Auret
BACKGROUND: Marine organism wound infections are common in coastal regions of Western Australia. Local treatment guidelines are based on studies from elsewhere. The objective of this article was to identify the causative organisms in marine wounds sustained in the subtropical and tropical coastal waters of the Indian Ocean, Gascoyne region (north-west), Western Australia. METHODS: This was a prospective study. A single wound swab was taken from 28 consenting patients who presented with a suppurating marine wound to the emergency departments of Carnarvon and Exmouth hospitals...
December 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29464174/suture-technique-to-prevent-air-leakage-during-negative-pressure-wound-therapy-in-fournier-gangrene
#9
Feng-Shu Chang, Chieh Chou, Chuan-Yu Hu, Shu-Hung Huang
Background: The use of negative-pressure wound therapy (NPWT) for Fournier gangrene management is well documented; however, it is difficult to fixate GranuFoam dressings and maintain an airtight seal over the perineum area. We developed a simple method to facilitate GranuFoam fixation and improve airtight sealing. Methods: The Fournier's gangrene severity index (FGSI) score less than 9 was collected in from January 2015 to October 2016. All 13 patients underwent fasciotomy, and NPWT was applied directly on fasciotomy wounds after the debridement of infected tissue...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29464150/incisional-negative-pressure-wound-therapy-for-prevention-of-wound-healing-complications-following-reduction-mammaplasty
#10
Robert D Galiano, Donald Hudson, Joseph Shin, René van der Hulst, Volkan Tanaydin, Risal Djohan, Franck Duteille, John Cockwill, Sarah Megginson, Elizabeth Huddleston
Background: It has been proposed that negative pressure wound therapy (NPWT) applied prophylactically to a closed incision may decrease the incidence of wound complications. Patients undergoing reduction mammaplasty are at risk of wound complications such as delayed healing, infection, and dehiscence, and the bilateral nature of the surgery allows for a within-patient randomized study to evaluate incisional NPWT's effect in reducing healing complications. Methods: In this multicenter trial, 200 patients undergoing bilateral reduction mammaplasty were treated with PICO Single-Use NPWT System or standard wound-care dressings randomized to right or left breast for up to 14 days to enable within-patient comparison...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29463493/effect-of-impulsive-compression-treatment-on-postoperative-complications-after-open-peripheral-vascular-revascularization-in-situ-protocol-for-a-randomized-control-trial
#11
Tenna Klit, Marie Dahl, Kim Christian Houlind, Hans Ravn
BACKGROUND: In patients with critical leg ischemia (CLI), the standard operative choice is an in situ bypass to the lower extremity to improve the patients´ prognosis and quality of life. Postoperative complications after surgery occur in 18 % of the patients, prolonging hospitalization and convalescence. The main operative complication is edema. This can be prevented by early mobilization or stimulation of the natural venous pump in the leg. OBJECTIVE: To investigate whether compression therapy with foot pump reduces postoperative edema, facilitates wound healing of the operation wounds, promotes healing of ischemic ulcers, and shortens hospitalization, increasing and improving the patient's subjective quality of life faster...
February 20, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29463159/prophylactically-applied-hydrofilm-polyurethane-film-dressings-reduce-radiation-dermatitis-in-adjuvant-radiation-therapy-of-breast-cancer-patients
#12
Leonard Christopher Schmeel, David Koch, Sabina Stumpf, Christina Leitzen, Birgit Simon, Heinrich Schüller, Susanne Vornholt, Felix Schoroth, Thomas Müdder, Fred Röhner, Stephan Garbe, Frederic Carsten Schmeel, Hans Heinz Schild, Timo Martin Wilhelm-Buchstab
PURPOSE: Radiation-induced skin injury represents one of the most common side effects in breast cancer patients receiving adjuvant whole-breast radiotherapy. Numerous systemic and topical treatments have been studied in the prevention and management of radiation-induced skin injury without providing sustainable treatment strategies. While superficial barrier-forming skin products such as dressings are the standard of care in wound care management, their utilization as preventive treatment approach in radiotherapy has barely attracted attention...
February 20, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29462673/heterotopic-ossification-and-lessons-learned-from-fifteen-years-at-war-a-review-of-therapy-novel-research-and-future-directions-for-military-and-civilian-orthopaedic-trauma
#13
REVIEW
Benjamin W Hoyt, Gabriel J Pavey, Benjamin K Potter, Jonathan A Forsberg
Heterotopic ossification, the formation of bone in soft tissues, is a common complication of the high-energy extremity trauma sustained in modern armed conflict. In the past 15 years, military treatment facilities and aligned laboratories have been in a unique position to study and treat this process due to the high volume of patients with these injuries secondary to blast trauma. The devastating nature of these wounds has limited traditional therapeutic options, necessitating alternative solutions to prophylaxis and initial treatment producing substantial advances in modeling, prophylaxis, detection, and therapy...
February 17, 2018: Bone
https://www.readbyqxmd.com/read/29462113/use-of-open-and-endovascular-surgical-techniques-to-manage-vascular-injuries-in-the-trauma-setting-a-review-of-the-american-association-for-the-surgery-of-trauma-prospective-observational-vascular-injury-trial-registry
#14
Edwin R Faulconer, Bernardino C Branco, Melissa N Loja, Kevin Grayson, James Sampson, Timothy C Fabian, John B Holcomb, Thomas Scalea, David Skarupa, Kenji Inaba, Nathaniel Poulin, Todd E Rasmussen, Joseph J Dubose
BACKGROUND: Vascular trauma data have been submitted to the American Association for the Surgery of Trauma PROspective Observational Vascular Injury Trial (PROOVIT) database since 2013. We present data to describe current use of endovascular surgery in vascular trauma. METHODS: Registry data from March 2013 to December 2016 were reviewed. All trauma patients who had an injury to a named artery, except the forearm and lower leg, were included. Arteries were grouped into anatomic regions and by compressible and noncompressible region for analysis...
March 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29461900/suppression-of-lrrc19-promotes-cutaneous-wound-healing-in-pressure-ulcers-in-mice
#15
Jie Sun, Zhijing Wang, Xirui Wang
The ischemia-reperfusion (I/R) induced skin lesion has been identified as primary cause of pressure ulcer. Better understanding of the mechanism is required for new therapy development. Leucine rich repeat containing protein 19 (LRRC19) is a recently discovered transmembrane protein containing leucine-rich repeats and plays a role in immune response. To investigate the role of LRRC19 in pressure ulcers, mouse ulcer model was established with two cycles of I/R. The expression of LRRC19 was assessed during injury...
February 20, 2018: Organogenesis
https://www.readbyqxmd.com/read/29460790/protein-and-micronutrient-deficiencies-in-patients-with-radiation-cystitis-and-outcome-after-hyperbaric-oxygen-therapy
#16
Valérie Platzer, Guillaume Perez, Anne Galinier, Michèle Genestal, Béatrice Riu-Poulenc, Leslie Gonzalez, Eric Huyghe, Sylvie Caspar-Bauguil
BACKGROUND & AIMS: Haemorrhagic radiation cystitis (HRC) is a late complication of pelvic radiotherapy. Severe cases are difficult to treat due to persistent or recurrent bleeding, despite urological and hyperbaric oxygen therapy (HBOT). However, wound healing requires a good nutritional status. In this respect, we aimed at analysing the nutritional status of patients with HRC prior to the onset of HBOT and at highlighting predictive nutritional factors of outcome. METHODS: Data were retrospectively collected from a cohort of 179 patients with HRC (between 2011 and 2015)...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460174/management-of-closed-sternal-incision-after-bilateral-internal-thoracic-artery-grafting-with-a-single-use-negative-pressure-system
#17
Giuseppe Gatti, Miroslaw Ledwon, Laszlo Gazdag, Federica Cuomo, Aniello Pappalardo, Theodor Fischlein, Giuseppe Santarpino
Single-use, closed incision management (CIM) systems offer a practical means of delivering negative pressure wound therapy to patients. This prospective study evaluates the Prevena™ Therapy system in a cohort of coronary patients at high risk of deep sternal wound infection (DSWI). Fifty-three consecutive patients undergoing bilateral internal thoracic artery (BITA) grafting were preoperatively elected for CIM with the Prevena™ Therapy system, which was applied immediately after surgery. The actual rate of DSWI in these patients was compared with the expected risk of DSWI according to two scoring systems specifically created to predict either DSWI after BITA grafting (Gatti score) or major infections after cardiac surgery (Fowler score)...
February 19, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29457376/delivery-of-allogeneic-adipose-stem-cells-in-polyethylene-glycol-fibrin-hydrogels-as-an-adjunct-to-meshed-autografts-after-sharp-debridement-of-deep-partial-thickness-burns
#18
David M Burmeister, Randolph Stone, Nicole Wrice, Alfred Laborde, Sandra C Becerra, Shanmugasundaram Natesan, Robert J Christy
Harvesting of autografts results in donor site morbidities and is limited in scenarios such as large total body surface area burns. In these instances, coverage is increased by meshing grafts at the expense of delayed biologic closure. Moreover, graft meshing increases the likelihood of contraction and hypertrophic scarring, limits range of motion, and worsens cosmesis. Many tissue engineering technologies have touted the promise of adipose-derived stem cells (ASCs) for burn wounds. The primary objective of the current study was to determine feasibility and efficacy of in situ ASC delivery via PEGylated fibrin (FPEG) hydrogels as adjuncts to meshed split thickness skin grafts in a porcine model...
February 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29457008/a-review-of-platelet-rich-plasma-history-biology-mechanism-of-action-and-classification
#19
REVIEW
Rubina Alves, Ramon Grimalt
Platelet-rich plasma (PRP) is currently used in different medical fields. The interest in the application of PRP in dermatology has recently increased. It is being used in several different applications as in tissue regeneration, wound healing, scar revision, skin rejuvenating effects, and alopecia. PRP is a biological product defined as a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline. It is obtained from the blood of patients collected before centrifugation...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29457005/effectiveness-of-platelet-rich-plasma-for-androgenetic-alopecia-a-review-of-the-literature
#20
REVIEW
Jessica Cervantes, Marina Perper, Lulu L Wong, Ariel E Eber, Alexandra C Villasante Fricke, Tongyu Cao Wikramanayake, Joaquin J Jimenez
Androgenetic alopecia (AGA) is a hair loss disorder affecting 80% of men and 50% of women throughout their lifetime. Therapies for AGA are limited and there is no cure. There is a high demand for hair restoration. Platelet-rich plasma (PRP), a treatment modality shown to promote wound healing, has also been explored as a treatment for AGA. This literature review was conducted to assess the effectiveness of PRP treatment for AGA. Twelve studies conducted from 2011 to 2017 were evaluated and summarized by study characteristics, mode of preparation, and treatment protocols...
January 2018: Skin Appendage Disorders
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