keyword
https://read.qxmd.com/read/38488660/nickel-induces-epithelial-mesenchymal-transition-in-pulmonary-fibrosis-in-mice-via-activation-of-the-oxidative-stress-mediated-tgf-%C3%AE-1-smad-signaling-pathway
#21
JOURNAL ARTICLE
Shanchuan Cao, Heng Yin, Xinglai Li, Xin Zeng, Jingbo Liu
Nickel (Ni) is recognized as a carcinogenic metal, and its widespread use has led to severe environmental and health problems. Although the lung is among the main organs affected by Ni, the precise mechanisms behind this effect remain poorly understood. This study aimed to elucidate the physiological mechanisms underlying Ni-induced pulmonary fibrosis (PF), using various techniques including histopathological detection, biochemical analysis, immunohistochemistry, western blotting, and quantitative real-time PCR...
March 15, 2024: Environmental Toxicology
https://read.qxmd.com/read/38485319/loeys-dietz-syndrome-with-a-novel-in-frame-smad3-deletion-diagnosed-as-a-result-of-postpartum-aortic-dissection-a-case-report
#22
Takeshi Nagao, Momoko Inoue, Yuki Ito, Takashi Kunihara, Hiroshi Kawame, Osamu Samura, Aikou Okamoto
OBJECTIVE: Loeys-Dietz syndrome (LDS) is a rare, autosomal dominant connective tissue disorder which can aggressively affect the aortic vasculature. Limited information is available regarding its impact on pregnancy and postpartum outcomes. CASE REPORT: A pregnant 38-year-old nulliparous woman with mild aortic regurgitation and family history of aortic aneurysms presented with an aortic root measuring 49 mm. Despite concerns of an underlying connective tissue disorder, a definitive diagnosis was not reached...
March 2024: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/38481818/carbonic-anhydrase-3-is-required-for-cardiac-repair-post-myocardial-infarction-via-smad7-smad2-3-signaling-pathway
#23
JOURNAL ARTICLE
Yuanyuan Su, Dongmei Shi, Guofang Xia, Yujia Liu, Longwei Xu, Ling Dao, Xia Lu, Chengxing Shen, Congfeng Xu
Appropriate fibrosis is required to prevent subsequent adverse remodeling and heart failure post myocardial infarction (MI), and cardiac fibroblasts (CFs) play a critical role during the process. Carbonic anhydrase 3 (CAR3) is an important mediator in multiple biological processes besides its CO2 hydration activity; however, the role and underlying mechanism of CAR3 on cardiac repair post MI injury remains unknown. Here, we found that CAR3 expression was up-regulated in cardiac tissue in infarct area at the reparative phase of MI, with a peak at 7 days post MI...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38476010/aberrant-timp-1-production-in-tumor-associated-fibroblasts-drives-the-selective-benefits-of-nintedanib-in-lung-adenocarcinoma
#24
JOURNAL ARTICLE
Paula Duch, Natalia Díaz-Valdivia, Marta Gabasa, Rafael Ikemori, Marselina Arshakyan, Patricia Fernández-Nogueira, Alejandro Llorente, Cristina Teixido, Josep Ramírez, Javier Pereda, Lourdes Chuliá-Peris, José Marcelo Galbis, Frank Hilberg, Noemí Reguart, Derek C Radisky, Jordi Alcaraz
The fibrotic tumor microenvironment is a pivotal therapeutic target. Nintedanib, a clinically approved multikinase antifibrotic inhibitor, is effective against lung adenocarcinoma (ADC) but not squamous cell carcinoma (SCC). Previous studies have implicated the secretome of tumor-associated fibroblasts (TAFs) in the selective effects of nintedanib in ADC, but the driving factor(s) remained unidentified. Here we examined the role of tissue inhibitor of metalloproteinase-1 (TIMP-1), a tumor-promoting cytokine overproduced in ADC-TAFs...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38474011/transcriptional-landscape-of-cut-class-homeobox-genes-in-blastic-plasmacytoid-dendritic-cell-neoplasm
#25
JOURNAL ARTICLE
Stefan Nagel, Ulfert Rand, Claudia Pommerenke, Corinna Meyer
Homeobox genes encode developmental transcription factors regulating tissue-specific differentiation processes and drive cancerogenesis when deregulated. Dendritic cells (DCs) are myeloid immune cells occurring as two types, either conventional or plasmacytoid DCs. Recently, we showed that the expression of NKL-subclass homeobox gene VENTX is restricted to conventional DCs, regulating developmental genes. Here, we identified and investigated homeobox genes specifically expressed in plasmacytoid DCs (pDCs) and derived blastic plasmacytoid dendritic cell neoplasm (BPDCN)...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468370/curcumin-modulates-nox-gene-expression-and-ros-production-via-p-smad3c-in-tgf-%C3%AE-activated-hepatic-stellate-cells
#26
JOURNAL ARTICLE
Samaneh Salehipour Bavarsad, Shahla Asadizade, Mahdi Hatami, Mojtaba Rashidi, Benyamin Kabizade, Elham Elham
BACKGROUND: Liver fibrosis, linked to HSCs, occurs when a healthy liver sustains damage, impairing its function. NOXs (1, 2, and 4) generate ROS during injuries, leading to fibrosis. The present study aimed to investigate the effects of curcumin in reducing NOX and ROS levels. This compound was also studied for its effects on NOXs, ROS production, and Smad3 phosphorylation in TGF-β-activated human HSCs. METHODS: MTT assay was employed to investigate the cytotoxic effects of curcumin on HSCs...
October 28, 2023: Iranian Biomedical Journal
https://read.qxmd.com/read/38467649/ythdf2-governs-muscle-size-through-a-targeted-modulation-of-proteostasis
#27
JOURNAL ARTICLE
Christopher J Gilbert, Charles P Rabolli, Volha A Golubeva, Kristina M Sattler, Meifang Wang, Arsh Ketabforoush, W David Arnold, Christoph Lepper, Federica Accornero
The regulation of proteostasis is fundamental for maintenance of muscle mass and function. Activation of the TGF-β pathway drives wasting and premature aging by favoring the proteasomal degradation of structural muscle proteins. Yet, how this critical post-translational mechanism is kept in check to preserve muscle health remains unclear. Here, we reveal the molecular link between the post-transcriptional regulation of m6 A-modified mRNA and the modulation of SMAD-dependent TGF-β signaling. We show that the m6 A-binding protein YTHDF2 is essential to determining postnatal muscle size...
March 11, 2024: Nature Communications
https://read.qxmd.com/read/38465579/cleaved-spp1-rich-extracellular-vesicles-from-osteoclasts-promote-bone-regeneration-via-tgf%C3%AE-1-smad3-signaling
#28
JOURNAL ARTICLE
Abdullah Faqeer, Mengzhen Wang, Gulzar Alam, Arshad Ahmed Padhiar, Dexiu Zheng, Zhiming Luo, Irene Shuping Zhao, Guangqian Zhou, Jeroen J J P van den Beucken, Huanan Wang, Yang Zhang
Bone remodeling is a tightly coupled process between bone forming osteoblasts (OBs) and bone resorbing osteoclasts (OCs) to maintain bone architecture and systemic mineral homeostasis throughout life. However, the mechanisms responsible for the coupling between OCs and OBs have not been fully elucidated. Herein, we first validate that secreted extracellular vesicles by osteoclasts (OC-EVs) promote osteogenic differentiation of mesenchymal stem cells (MSCs) and further demonstrate the efficacy of osteoclasts and their secreted EVs in treating tibial bone defects...
December 2023: Biomaterials
https://read.qxmd.com/read/38464061/sm22%C3%AE-deficiency-promoting-vascular-fibrosis-via-srf-smad3-mediated-activation-of-col1a2-transcription-following-arterial-injury
#29
Jianbin Shen, Donghong Ju, Shichao Wu, Jiawei Zhao, Lucynda Pham, Alejandro Ponce, Maozhou Yang, Hui Joyce Li, Kezhong Zhang, Zhe Yang, Youming Xie, Li Li
Vascular fibrosis, characterized by increased Type I collagen expression, significantly contributes to vascular remodeling. Our previous studies show that disrupting the expression of SM22α (aka SM22, Tagln) induces extensive vascular remodeling following arterial injury, involving oxidative stress, inflammation, and chondrogenesis within the vessel wall. This study aims to investigate the molecular mechanisms underlying the transcription of Col1a2 , a key fibrotic extracellular matrix marker. We observed upregulation of COL1A2 in the arterial wall of Sm22 -/- mice following carotid injury...
February 27, 2024: Research Square
https://read.qxmd.com/read/38463775/bioinformatics-analysis-and-experimental-validation-of-key-genes-associated-with-lumbar-disc-degeneration-and-biomechanics
#30
JOURNAL ARTICLE
Xiyu Liu, Lipeng He, Nan Wang, Lin Xie, Bin Wu
BACKGROUND: Lumbar disc degeneration (LDD) is an important pathological basis for the development of degenerative diseases of the lumbar spine. Most clinical patients have low back pain as their main symptom. The deterioration of the biomechanical environment is an important cause of LDD. Although there is a large amount of basic research on LDD, there are fewer reports that correlate biomechanical mechanisms with basic research. Our research aims to identify 304 key genes involved in LDD due to biomechanical deterioration, using a bioinformatics approach...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38459489/effect-of-strontium-on-transcription-factors-identified-by-transcriptome-analyses-of-bovine-ruminal-epithelial-cells
#31
JOURNAL ARTICLE
Panpan Tan, Yazhou Wang, Linshan Mei, Juan J Loor, Chenxu Zhao, Yezi Kong, Fangyuan Zeng, Baoyu Zhao, Jianguo Wang
BACKGROUND: Strontium (Sr) has similar physicochemical properties as calcium (Ca) and is often used to evaluate the absorption of this mineral. Because the major route of Ca absorption in the bovine occurs in the rumen, it is essential to understand whether Sr impacts the ruminal epithelial cells and to what extent. RESULTS: In the present study, RNA sequencing and assembled transcriptome assembly were used to identify transcription factors (TFs), screening and bioinformatics analysis in bovine ruminal epithelial cells treated with Sr...
March 8, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38458339/dpp8-9-inhibition-attenuates-the-tgf-%C3%AE-1-induced-excessive-deposition-of-extracellular-matrix-ecm-in-human-mesangial-cells-via-smad-and-akt-signaling-pathway
#32
JOURNAL ARTICLE
Ke Li, Yuzhan Zhang, Weihao Zhao, Rongrong Wang, Yan Li, Linting Wei, Li Wang, Xianghui Chen, Zhao Chen, Pengfei Liu, Na Nie, Xuefei Tian, Rongguo Fu
The pathogenesis of glomerular diseases is strongly influenced by abnormal extracellular matrix (ECM) deposition in mesangial cells. Dipeptidyl peptidase IV (DPPIV) enzyme family contains DPP8 and DPP9 involved in multiple diseases. However, the pathogenic roles of DPP8 and DPP9 in mesangial cells ECM deposition remain unclear. In this study, we observed that DPP8 and DPP9 were significantly increased in glomerular mesangial cells and podocytes in CKD patients compared with healthy individuals, and DPP9 levels were higher in the urine of IgAN patients than in control urine...
March 6, 2024: Toxicology Letters
https://read.qxmd.com/read/38453045/tgf-%C3%AE-1-smad3-driven-gli2-isoform-expression-contributes-to-aggressive-phenotypes-of-hepatocellular-carcinoma
#33
JOURNAL ARTICLE
Jia Ding, Yong-Yu Yang, Peng-Tao Li, Yue Ma, Li Zhang, Yuan Zhou, Cheng Jin, Hui-Yan Li, Yuan-Fei Zhu, Xiu-Ping Liu, Zheng-Jin Liu, Hu-Liang Jia, Ping-Guo Liu, Jian Wu
Hedgehog signaling is activated in response to liver injury, and modulates organogenesis. However, the role of non-canonical hedgehog activation via TGF-β1/SMAD3 in hepatic carcinogenesis is poorly understood. TGF-β1/SMAD3-mediated non-canonical activation was found in approximately half of GLI2-positive hepatocellular carcinoma (HCC), and two new GLI2 isoforms with transactivating activity were identified. Phospho-SMAD3 interacted with active GLI2 isoforms to transactivate downstream genes in modulation of stemness, epithelial-mesenchymal transition, chemo-resistance and metastasis in poorly-differentiated hepatoma cells...
March 5, 2024: Cancer Letters
https://read.qxmd.com/read/38443979/integrative-analysis-of-chromatin-accessibility-and-transcriptome-landscapes-in-the-induction-of-peritoneal-fibrosis-by-high-glucose
#34
JOURNAL ARTICLE
Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan'e Yao, Wei Wang, Guangbo Tang, Sen Zhou
BACKGROUND: Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis. METHODS: To elucidate the molecular mechanisms underlying this process, we conducted an integrated analysis of the transcriptome and chromatin accessibility profiles of human peritoneal mesothelial cells (HMrSV5) during high-glucose treatment. RESULTS: Our study identified 2775 differentially expressed genes (DEGs) related to high glucose-triggered pathological changes, including 1164 upregulated and 1611 downregulated genes...
March 5, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38441961/tgf-%C3%AE-1-induces-pd-1-expression-in-macrophages-through-smad3-stat3-cooperative-signaling-in-chronic-inflammation
#35
JOURNAL ARTICLE
Zhigang Lei, Rui Tang, Yu Wu, Chenxu Mao, Weijie Xue, Junyao Shen, Jiaojiao Yu, Xiaohong Wang, Xin Qi, Chuan Wei, Lei Xu, Jifeng Zhu, Yalin Li, Xiujun Zhang, Chunyan Ye, Xiaojun Chen, Xiaojun Yang, Sha Zhou, Chuan Su
Programmed cell death protein 1 (PD-1), a coinhibitory T-cell checkpoint, is also expressed on macrophages (Mφ) in pathogen- or tumor-driven chronic inflammation. Increasing evidence underscores the importance of PD-1 on Mφ for dampening immune responses. However, the mechanism governing PD-1 expression in Mφ in chronic inflammation remains largely unknown. TGF-β1 (transforming growth factor-β1) is abundant within chronic inflammatory microenvironments. Here, based on public databases, significant positive correlations between PDCD1 and TGFB1 gene expression were observed in most human tumors...
March 5, 2024: JCI Insight
https://read.qxmd.com/read/38434258/chinese-herbal-decoction-yi-qi-jian-pi-formula-exerts-anti-hepatic-fibrosis-effects-in-mouse-models-of-ccl-4-induced-liver-fibrosis
#36
JOURNAL ARTICLE
Shiyan Yang, Yajun Cheng, Xiaolong Wang, Suyang Yue, Xi Wang, Li Tang, Hailun Li, Jie Zhang, Qingping Xiong, Shanzhong Tan
BACKGROUND: Yi-Qi-Jian-Pi Formula (YQJPF) is a herbal medicine that is used to treat patients with liver failure. However, scientific evidence supporting the treatment of hepatic fibrosis with YQJPF has not been forthcoming. The present study aimed to determine the mechanisms underlying the anti-fibrotic effects of YQJPF in mouse models of hepatic fibrosis. METHODS: Mice were randomly assigned to control, hepatic fibrosis model, silymarin (positive treated), and low-, medium- and high-dose YQJPF (7...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38431184/functional-evidence-for-two-distinct-mechanisms-of-action-of-progesterone-and-selective-progesterone-receptor-modulator-on-uterine-leiomyomas
#37
JOURNAL ARTICLE
Gabriela Milewska, Donata Ponikwicka-Tyszko, Piotr Bernaczyk, Oana Lupu, Michal Szamatowicz, Maria Sztachelska, Agata Pilaszewicz-Puza, Mariusz Koda, Tomasz Bielawski, Monika Zbucka-Kretowska, Adam Pawelczyk, Jakub Tomaszewski, Xiangdong Li, Ilpo Huhtaniemi, Slawomir Wolczynski, Nafis A Rahman
OBJECTIVE: To study the specific mechanisms through which progesterone and selective progesterone receptor modulators impact the growth and synthesis/accumulation of the extracellular matrix in uterine leiomyomas. DESIGN: Laboratory study. SETTING: Academic Research Institutions. PATIENTS (S): This study involved reproductive-age women diagnosed with infertility-associated uterine leiomyomas, who underwent myomectomy either after selective progesterone receptor modulator ulipristal acetate treatment or without any pharmacological pre-treatment...
February 29, 2024: Fertility and Sterility
https://read.qxmd.com/read/38429926/nr4a1-enhances-wnt4-transcription-to-promote-osteogenic-differentiation-of-mesenchymal-stem-cells-and-alleviates-inflammation-inhibited-bone-regeneration
#38
JOURNAL ARTICLE
Yangshuai Gao, Yuming Zou, Dimitri Sokolowskei, Xin Xing, Robert J Tower, Zejia Lai, Jiawei Shi, Liheng Zhu, Quan Zheng, Aaron W James, Jiajia Xu, Zhongmin Zhang
Intense inflammatory response impairs bone marrow mesenchymal stem cell (BMSC)-mediated bone regeneration, with TGF-β1 being the most highly expressed cytokine. However, how to find effective and safe means to improve bone formation impaired by excessive TGF-β1 remains unclear. In this study, we found that the expression of orphan nuclear receptor Nr4a1, an endogenous repressor of TGF-β1, was suppressed directly by TGF-β1-induced Smad3 and indirectly by Hdac4, respectively. Importantly, Nr4a1 overexpression promoted BMSC osteogenesis and reversed TGF-β1-mediated osteogenic inhibition and pro-fibrotic effects...
February 29, 2024: Molecular Therapy
https://read.qxmd.com/read/38429437/a-cellular-model-provides-insights-into-the-pathogenicity-of-the-oncogenic-foxl2-somatic-variant-p-cys134trp
#39
JOURNAL ARTICLE
Laetitia Herman, Angélique Amo, Berangère Legois, Caterina Di Carlo, Reiner A Veitia, Anne-Laure Todeschini
BACKGROUND: FOXL2 is a transcription factor expressed in ovarian granulosa cells. A somatic variant of FOXL2 (c.402 C > G, p.Cys134Trp) is the hallmark of adult-type granulosa cell tumours. METHODS: We generated KGN cell clones either heterozygous for this variant (MUT) or homozygous for the wild-type (WT) allele by CRISPR/Cas9 editing. They underwent RNA-Seq and bioinformatics analyses to uncover pathways impacted by deregulated genes. Cell morphology and migration were studied...
March 1, 2024: British Journal of Cancer
https://read.qxmd.com/read/38420580/gradient-rotating-magnetic-fields-impairing-f-actin-related-gene-ccdc150-to-inhibit-triple-negative-breast-cancer-metastasis-by-inactivating-tgf-%C3%AE-1-smad3-signaling-pathway
#40
JOURNAL ARTICLE
Ge Zhang, Tongyao Yu, Xiaoxia Chai, Shilong Zhang, Jie Liu, Yan Zhou, Dachuan Yin, Chenyan Zhang
Triple-negative breast cancer (TNBC) is the most aggressive and lethal malignancy in women, with a lack of effective targeted drugs and treatment techniques. Gradient rotating magnetic field (RMF) is a new technology used in oncology physiotherapy, showing promising clinical applications due to its satisfactory biosafety and the abundant mechanical force stimuli it provides. However, its antitumor effects and underlying molecular mechanisms are not yet clear. We designed two sets of gradient RMF devices for cell culture and animal handling...
2024: Research: a science partner journal
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