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https://www.readbyqxmd.com/read/28719762/a-million-steps-developing-a-health-promotion-program-at-the-workplace-to-enhance-physical-activity
#1
María Eugenia González-Dominguez, José Manuel Romero-Sánchez, Antonio Ares-Camerino, Jose Carlos Marchena-Aparicio, Manuel Flores-Muñoz, Inés Infantes-Guzmán, José Manuel León-Asuero, Fernando Casals-Martín
The workplace is a key setting for the prevention of occupational risks and for promoting healthy activities such as physical activity. Developing a physically active lifestyle results in many health benefits, improving both well-being and quality of life. This article details the experience of two Spanish companies that implemented a program to promote physical exercise in the workplace, called "A Million Steps." This program aimed to increase the physical activity of participants, challenging them to reach at least a million steps in a month through group walks...
July 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28719753/exercise-prescriptions-for-training-and-rehabilitation-in-patients-with-heart-and-lung-disease
#2
Pietro Palermo, Ugo Corrà
Rehabilitation in patients with advanced cardiac and pulmonary disease has been shown to increase survival and improve quality of life among many other benefits. Exercise training is the fundamental ingredient in these rehabilitation programs. However, determining the amount of exercise is not straightforward or uniform. Most rehabilitation and training program fix the time of exercise and set the exercise intensity to the goals of the rehabilitation program and the exercise-related hurdles of the individual...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28719738/an-activator-blocker-pair-provides-a-controllable-on-off-switch-for-a-ketosteroid-isomerase-active-site-mutant
#3
Vandana Lamba, Filip Yabukarski, Daniel Herschlag
Control of enzyme activity is fundamental to biology and represents a long-term goal in bioengineering and precision therapeutics. While several powerful molecular strategies have been developed, limitations remain in their generalizability and dynamic range. We demonstrate a control mechanism via separate small molecules that turn on the enzyme (activator) and turn off the activation (blocker). We show that a pocket created near the active site base of the enzyme ketosteriod isomerase (KSI) allows efficient and saturable base rescue when the enzyme's natural general base is removed...
July 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28719734/tissue-engineering-of-a-composite-trachea-construct-using-autologous-rabbit-chondrocytes
#4
James E Dennis, Kristina G Bernardi, Thomas J Kean, Nelson E Liou, Tanya K Meyer
The repair of large tracheal segmental defects remains an unsolved problem. The goal of this study is to apply tissue engineering principles for the fabrication of large segmental trachea replacements. Engineered tracheal replacements composed of autologous cells ("neotracheas") were tested in a New Zealand White rabbit model. Neotracheas were formed in the rabbit neck by wrapping a silicone tube with consecutive layers of skin epithelium, platysma muscle and an engineered cartilage sheet, and allowing the construct to mature for 8-12 weeks...
July 18, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28719713/lymph-node-positive-cutaneous-nonmelanoma-skin-cancer-a-poor-prognosis-disease-in-need-of-treatment-intensification
#5
Lora S Wang, Elizabeth A Handorf, John A Ridge, Barbara A Burtness, Miriam N Lango, Ranee Mehra, Jeffrey C Liu, Thomas J Galloway
Locoregionally advanced nonmelanoma skin cancer (NMSC) has an aggressive clinical course characterized by high rates of treatment failure and poor survival compared with localized skin cancers. Our goal was to investigate multimodal therapy for lymph-node-positive NMSC. Data from patients with lymph-node-positive NMSC who underwent surgery and adjuvant therapy at a single tertiary center from 2002 to 2012 were retrospectively reviewed. Median follow-up was 1.8 years (range: 0.5 to 8.5). Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28719666/effects-of-prey-pitcher-age-and-microbes-on-acid-phosphatase-activity-in-fluid-from-pitchers-of-sarracenia-purpurea-sarraceniaceae
#6
Carl S Luciano, Sandra J Newell
Carnivory in pitcher plants generally involves digestion of prey, by the plant itself, by symbionts, or both. While symbionts appear to be important in the digestion of prey in Sarracenia purpurea, the importance of pitcher-derived enzymes is less well documented. Our goal was to reduce microbial numbers in pitcher fluid in order to measure the acid phosphatase activity attributable to the pitchers themselves. Preliminary experiments indicated that various antibiotics were minimally effective at reducing microbial populations and that antibiotic-resistant microbes were easily cultured from pitcher fluid...
2017: PloS One
https://www.readbyqxmd.com/read/28719661/minimizing-endpoint-variability-through-reinforcement-learning-during-reaching-movements-involving-shoulder-elbow-and-wrist
#7
David Marc Anton Mehler, Alexandra Reichenbach, Julius Klein, Jörn Diedrichsen
Reaching movements are comprised of the coordinated action across multiple joints. The human skeleton is redundant for this task because different joint configurations can lead to the same endpoint in space. How do people learn to use combinations of joints that maximize success in goal-directed motor tasks? To answer this question, we used a 3-degree-of-freedom manipulandum to measure shoulder, elbow and wrist joint movements during reaching in a plane. We tested whether a shift in the relative contribution of the wrist and elbow joints to a reaching movement could be learned by an implicit reinforcement regime...
2017: PloS One
https://www.readbyqxmd.com/read/28719334/precisely-tracking-childhood-death
#8
Tamer H Farag, Jeffrey P Koplan, Robert F Breiman, Shabir A Madhi, Penny M Heaton, Trevor Mundel, Jaume Ordi, Quique Bassat, Clara Menendez, Scott F Dowell
Little is known about the specific causes of neonatal and under-five childhood death in high-mortality geographic regions due to a lack of primary data and dependence on inaccurate tools, such as verbal autopsy. To meet the ambitious new Sustainable Development Goal 3.2 to eliminate preventable child mortality in every country, better approaches are needed to precisely determine specific causes of death so that prevention and treatment interventions can be strengthened and focused. Minimally invasive tissue sampling (MITS) is a technique that uses needle-based postmortem sampling, followed by advanced histopathology and microbiology to definitely determine cause of death...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719305/optimizing-household-chlorination-marketing-strategies-a-randomized-controlled-trial-on-the-effect-of-price-and-promotion-on-adoption-in-haiti
#9
Michael Ritter, Eveline Camille, Christophe Velcine, Rose-Kerline Guillaume, Daniele Lantagne
Household water treatment can reduce diarrheal morbidity and mortality in developing countries, but adoption remains low and supply is often unreliable. To test effects of marketing strategies on consumers and suppliers, we randomized 1,798 households in rural Haiti and collected data on purchases of a household chlorination product for 4 months. Households received randomly selected prices ($0.11-$0.56 per chlorine bottle), and half received monthly visits from sales agents. Each $0.22 drop in price increased purchases by 0...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719247/telehealth-in-schools-using-a-systematic-educational-model-based-on-fiction-screenplays-interactive-documentaries-and-three-dimensional-computer-graphics
#10
Diogo Julien Miranda, Chao Lung Wen
BACKGROUND: Preliminary studies suggest the need of a global vision in academic reform, leading to education re-invention. This would include problem-based education using transversal topics, developing of thinking skills, social interaction, and information-processing skills. We aimed to develop a new educational model in health with modular components to be broadcast and applied as a tele-education course. MATERIALS AND METHODS: We developed a systematic model based on a "Skills and Goals Matrix" to adapt scientific contents on fictional screenplays, three-dimensional (3D) computer graphics of the human body, and interactive documentaries...
July 18, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28719236/applying-an-artificial-neural-network-model-for-developing-a-severity-score-for-patients-with-hereditary-amyloid-polyneuropathy
#11
Shenia Novis, Felipe Machado, Victor B Costa, Debora Foguel, Marcia W Cruz, José Manoel de Seixas
Hereditary (familial) amyloid polyneuropathy (FAP) is a systemic disease that includes a sensorimotor polyneuropathy related to transthyretin (TTR) mutations. So far, a scale designed to classify the severity of this disease has not yet been validated. This work proposes the implementation of an artificial neural network (ANN) in order to develop a severity scale for monitoring the disease progression in FAP patients. In order to achieve this goal, relevant symptoms and laboratory findings were collected from 98 Brazilian patients included in THAOS - the Transthyretin Amyloidosis Outcomes Survey...
July 18, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28719066/insights-into-optimal-basal-insulin-titration-in-type-2-diabetes-results-of-a-quantitative-survey
#12
Lori Berard, Mireille Bonnemaire, Marie Mical, Steve Edelman
AIMS: Basal insulin (BI) treatment initiation and dose titration in type 2 diabetes (T2DM) are often delayed. Such "clinical inertia" results in poor glycemic control and high risk of long-term complications. This survey aimed to determine healthcare professional (HCP) and patient attitudes to BI initiation and titration. METHODS: An online survey (July-August 2015) including HCPs and patients with T2DM in the USA, France and Germany. Patients were ≥18 years old and had been on BI for 6-36 months, or discontinued BI within the previous 12 months...
July 18, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28718982/design-and-solution-phase-synthesis-of-membrane-targeting-lipopeptides-with-selective-antibacterial-activity
#13
Mohini Mohan Konai, Utsarga Adhikary, Jayanta Haldar
Designing selective antibacterial molecules remains an unmet goal in the field of membrane targeting agents. To this aim, herein we report the rational design and synthesis of a new class of lipopeptides which possess highly selective bacterial killing over mammalian cells. The selective interaction with bacterial over mammalian membranes was established through various spectroscopic as well as microscopic experiments including biophysical studies with the model membranes. A detailed antibacterial structure-activity relationship was delineated after preparing a series of molecules consisting of the peptide moieties with varied sequence of amino acids such as D-phenylalanine, D-leucine and D-lysine...
July 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28718937/wound-healing-in-epidermolysis-bullosa
#14
L B Tuderman, J E Mellerio
Epidermolysis bullosa (EB) is a group of inherited diseases characterised by recurrent skin blistering due to impaired epidermal or dermo-epidermal adhesion. In some subtypes, damage to internal organs causes serious comorbidities, and an increased risk of early and aggressive squamous cell carcinoma (SCC) characterizes recessive dystrophic EB (RDEB). It is likely that EB will only be cured by mutation-correction interventions, but until that goal becomes a reality we need to pool and extend knowledge about wound management and other strategies to improve quality of life for people with EB...
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28718870/-motivational-goals-and-couple-relationship-quality-in-a-sample-of-individuals-with-infertility
#15
Misa Yamanaka-Altenstein, Emanuel Henrich, Nina Heinrichs
3,5-16,6% of couples worldwide with childwish suffer from infertility, and about 20% thereof show clinically relevant psychological symptoms. Until now it remained unclear, up to which extent motivational factors are associated with psychological distress when suffering from infertility. The goal of this study was to assess individual motivational factors in a sample of infertile people, and to explore their effect on psychological distress. Additionally, the role of couple relationship quality as a dyadic predictor was to be examined...
June 29, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28718837/interactivity-and-trust-as-antecedents-of-e-training-use-intention-in-nigeria-a-structural-equation-modelling-approach
#16
A U Alkali, Nur Naha Abu Mansor
BACKGROUND: The last few decades saw an intense development in information technology (IT) and it has affected the ways organisations achieve their goals. Training, in every organisation is an ongoing process that aims to update employees' knowledge and skills towards goals attainment. Through adequate deployment of IT, organisations can effectively meet their training needs. However, for successful IT integration in training, the employees who will use the system should be positively disposed towards it...
July 18, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28718812/therapeutic-efficacy-of-the-novel-stimuli-sensitive-nano-ferritins-containing-doxorubicin-in-a-head-and-neck-cancer-model
#17
Verena Damiani, Elisabetta Falvo, Giulio Fracasso, Luca Federici, Martina Pitea, Vincenzo De Laurenzi, Gianluca Sala, Pierpaolo Ceci
Doxorubicin is employed alone or in combination for the treatment of several hematological and solid malignancies; despite its efficacy, there are associated cardiotoxicity limits both in its application in patients with heart disease risk factors and also in its long-term use. HFt-MP-PAS40 is a genetically engineered human ferritin heavy chain (HFt)-based construct able to efficiently entrap and deliver doxorubicin to cancer cells. HF-MP-PAS contains a short motif sequence (defined as MP) responsive to proteolytic cleavage by tumor matrix metalloproteases (MMPs), located between each HFt subunit and a masking polypeptide sequence rich in proline (P), alanine (A), and serine (S) residues (PAS)...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28718757/the-impact-of-dispositional-variables-of-elders-relatives-and-paid-caregivers-on-elders-empowerment-and-life-satisfaction
#18
Manuela Tomai, Lina Pezzuti, Minou Mebane, Maura Benedetti, Annalisa Moro
Background/Study Context: The impact of dispositional characteristic of elders' closest network members on elders' life satisfaction and empowerment has remained largely unexplored. This innovative study aimed to assess the impact of dispositional variables of elders, relatives, and paid caregivers on life satisfaction and empowerment of elders. METHODS: One hundred forty-three triads (one elder, one paid caregiver, and one relative) completed six scales measuring modifiable personality characteristics (loneliness, optimism, regulation of positive and negative emotions), life satisfaction, and sense of empowerment...
July 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28718753/aging-and-list-wide-modulations-of-strategy-execution-a-study-in-arithmetic
#19
Thomas Hinault, Patrick Lemaire
Background/Study Context: This study aimed at further our understanding of the cognitive processes involved during strategy execution, and how the processes involved change with age. More specifically, the main goal was to investigate whether poorer-strategy effects (i.e., poorer performance when a cued strategy is not the best) and sequential modulations of poorer-strategy effects (i.e., decreased poorer-strategy effects on current problems following poorer-strategy problems compared with after better-strategy problems) are influenced by proportions of poorer-strategy problems...
July 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28718712/comparison-of-domains-of-self-reported-physical-activity-between-kenyan-adult-urban-slum-dwellers-and-national-estimates
#20
Hilde E Groot, Stella K Muthuri
BACKGROUND: Non-communicable diseases (NCDs) - largely the result of modifiable behavioral risks such as physical inactivity that gradually develop into physiological risks - are a main cause of morbidity and mortality worldwide. In Kenya, a nationally representative STEPwise survey of risk factors for NCDs established that 10.8% of Kenyans accumulated low levels of total physical activity. OBJECTIVES: The goal of our analyses was to compare domains of self-reported physical activity in two Nairobi slums to national estimates...
2017: Global Health Action
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