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https://www.readbyqxmd.com/read/29036939/female-genital-mutilation-reconstruction-a-preliminary-report
#1
Catherine S Chang, David W Low, Ivona Percec
Background: Female genital mutilation (FGM) is internationally recognized as a violation of human rights. Though rarely discussed, FGM is prevalent, affecting hundreds of millions of females worldwide. Objectives: We believe that is important for plastic surgeons to be informed and prepared to address the surgical and emotional needs of these women. We present our experience on treatment of women subjected to FGM. Methods: Three consecutive patients were treated by our clitoral restoration procedure...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29036935/laser-powder-cladding-of-ti-6al-4v-%C3%AE-%C3%AE-alloy
#2
Samar Reda Al-Sayed Ali, Abdel Hamid Ahmed Hussein, Adel Abdel Menam Saleh Nofal, Salah Elden Ibrahim Hasseb Elnaby, Haytham Abdelrafea Elgazzar, Hassan Abdel Sabour
Laser cladding process was performed on a commercial Ti-6Al-4V (α + β) titanium alloy by means of tungsten carbide-nickel based alloy powder blend. Nd:YAG laser with a 2.2-KW continuous wave was used with coaxial jet nozzle coupled with a standard powder feeding system. Four-track deposition of a blended powder consisting of 60 wt % tungsten carbide (WC) and 40 wt % NiCrBSi was successfully made on the alloy. The high content of the hard WC particles is intended to enhance the abrasion resistance of the titanium alloy...
October 15, 2017: Materials
https://www.readbyqxmd.com/read/29036895/low-cost-lab-on-chip-for-the-colorimetric-detection-of-nitrate-in-mineral-water-products
#3
Mohammad F Khanfar, Wisam Al-Faqheri, Ala'aldeen Al-Halhouli
The diagnostics of health status and the quality of drinking water are among the most important United Nations sustainable development goals. However, in certain areas, wars and instability have left millions of people setting in refugee camps and dangerous regions where infrastructures are lacking and rapid diagnostics of water quality and medical status are critical. In this work, microfluidic testing chips and photometric setups are developed in cheap and portable way to detect nitrate concentrations in water...
October 14, 2017: Sensors
https://www.readbyqxmd.com/read/29036864/employment-pathways-of-individuals-with%C3%A2-spinal-cord-injury-living-in%C3%A2-switzerland-a-qualitative-study
#4
Albert Marti, Reuben Escorpizo, Urban Schwegler, Stefan Staubli, Bruno Trezzini
BACKGROUND: Labour market participation (LMP) represents a key goal of rehabilitation for individuals with spinal cord injury (SCI). To achieve this goal, Swiss SCI rehabilitation centres seek, together with their clients, viable follow-up solutions for returning to work after initial rehabilitation. However, the long-term outcomes of such vocational follow-up solutions have not been investigated so far, and there is a paucity of knowledge regarding the various types of employment pathways that persons with SCI living in Switzerland may experience...
October 9, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036841/home-and-family-in-cognitive-rehabilitation-after-brain-injury-implementation-of-social-reserves
#5
Jesper Mogensen, Camilla Wulf-Andersen
The focus of the present article is the home and family environment of patients suffering acquired brain injury. In order to obtain the optimal outcome of posttraumatic cognitive rehabilitation it is important (a) to obtain a sufficient intensity of rehabilitative training, (b) to achieve the maximum degree of generalization from formalized training to the daily environment of the patient, and (c) to obtain the best possible utilization of "cognitive reserves" in the form of cognitive abilities and "strategies" acquired pretraumatically...
October 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036811/sildenafil-improves-vascular-and-metabolic-function-in-patients-with-alzheimer-s-disease
#6
Min Sheng, Hanzhang Lu, Peiying Liu, Yang Li, Harshan Ravi, Shin-Lei Peng, Ramon Diaz-Arrastia, Michael D Devous, Kyle B Womack
BACKGROUND: Alzheimer's disease (AD) is the leading cause of degenerative dementia in the aging population. Patients with AD have alterations in cerebral hemodynamic function including reduced cerebral blood flow (CBF) and cerebral metabolic rate. Therefore, improved cerebrovascular function may be an attractive goal for pharmaceutical intervention in AD. OBJECTIVE: We wished to observe the acute effects of sildenafil on cerebrovascular function and brain metabolism in patients with AD...
October 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036703/spiritual-religious-distress-is-associated-with-pain-catastrophizing-and-interference-in-veterans-with-chronic-pain
#7
J Irene Harris, Timothy Usset, Laura Krause, Damien Schill, Berdette Reuer, Rhonda Donahue, Crystal L Park
Objective: Few studies have examined relations between one important aspect of spiritual/religious functioning-spiritual distress-and pain-related outcomes, and none has examined how spiritual distress and depression conjointly relate to chronic pain. The goal of the present study, then, was to examine veterans' spiritual distress as a predictor of two aspects of chronic pain, catastrophizing and interference, testing a mediational model of depression. Design: Four hundred thirty-six patients seeking treatment in a chronic pain management clinic responded to a mailed survey assessing demographics, spiritual distress, depression, pain catastrophizing, and pain interference...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036661/the-impact-of-the-brazilian-family-health-strategy-and-the-conditional-cash-transfer-on-tuberculosis-treatment-outcomes-in-rio-de-janeiro-an-individual-level-analysis-of-secondary-data
#8
Betina Durovni, Valeria Saraceni, Mariana Soares Puppin, Wagner Tassinari, Oswaldo G Cruz, Solange Cavalcante, Claudia Medina Coeli, Anete Trajman
Background: Unsuccessful tuberculosis outcomes are frequent; bold policies are needed to end the tuberculosis (TB) epidemic to attain the third Sustainable Development Goal (SDG) by 2030. We examined the effect of the Family Health Strategy (FHS) and its interactions with the conditional cash transfer programme (CTP) on TB outcomes in Rio de Janeiro, Brazil. Methods: We performed individual-based analyses of a database resulting from deterministic and probabilistic linkages of the TB information system, FHS registries and CTP payrolls...
September 28, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29036632/mapping-compulsivity-in-the-dsm-5-obsessive-compulsive-and-related-disorders-cognitive-domains-neural-circuitry-and-treatment
#9
Naomi A Fineberg, Annemieke M Apergis-Schoute, M Matilde Vaghi, Paula Banca, Claire M Gillan, Valerie Voon, Samuel R Chamberlain, Cinosi Eduardo, Reid Jemma, Sonia Shahper, Edward T Bullmore, Barbara J Sahakian, Trevor W Robbins
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioural inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder (OCD), distributed network perturbation appears focussed around the pre-frontal cortex, caudate, putamen and associated neuro-circuitry...
September 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29036572/dose-effect-of-the-33s-n-%C3%AE-30si-reaction-in-bnct-using-the-new-n_tof-cern-data
#10
M Sabaté-Gilarte, J Praena, I Porras, J M Quesada
33S is a stable isotope of sulphur which is being studied as a potential cooperative target for Boron Neutron Capture Therapy (BNCT) in accelerator-based neutron sources because of its large (n,α) cross section in the epithermal neutron energy range. Previous measurements resolved the resonances with a discrepant description of the lowest-lying and strongest one (at 13.5 keV). However, the evaluations of the major databases do not include resonances, except EAF-2010 which shows smaller values in this range than the experimental data...
September 23, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036569/opportunities-for-epidemiologists-in-implementation-science-a-primer
#11
Gila Neta, Ross C Brownson, David A Chambers
The field of epidemiology has been defined as the study of the spread and control of disease. However, epidemiology frequently focuses on studies of etiology and distribution of disease at the cost of understanding the best ways to control disease. Moreover, only a small fraction of scientific discoveries is translated into public health practice, and the process from discovery to translation is exceedingly slow. Given the importance of translational science, the future of epidemiologic training should include competency in implementation science, whose goal is to rapidly move evidence into practice...
September 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036474/casanova-a-multiclass-support-vector-machine-model-for-the-classification-of-human-sperm-motility-patterns
#12
Summer G Goodson, Sarah White, Alicia M Stevans, Sanjana Bhat, Chia-Yu Kao, Scott Jaworski, Tamara R Marlowe, Martin Kohlmeier, Leonard McMillan, Steven H Zeisel, Deborah A O'Brien
The ability to accurately monitor alterations in sperm motility is paramount to understanding multiple genetic and biochemical perturbations impacting normal fertilization. Computer-aided sperm analysis (CASA) of human sperm typically reports motile percentage and kinematic parameters at the population level, and uses kinematic gating methods to identify subpopulations such as progressive or hyperactivated sperm. The goal of this study was to develop an automated method that classifies all patterns of human sperm motility during in vitro capacitation following the removal of seminal plasma...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29036454/mirror-and-absence-of-counter-mirror-responses-to-action-sounds-measured-with-tms
#13
Luca F Ticini, Simone Schütz-Bosbach, Florian Waszak
To what extent is the mirror neuron mechanism malleable to experience? The answer to this question can help characterising its ontogeny and its role in social cognition. Some suggest that it develops through sensorimotor associations congruent with our own actions. Others argue for its extreme volatility that will encode any sensorimotor association in the environment. Here, we added to this debate by exploring the effects of short goal-directed "mirror" and "counter-mirror" trainings (a "mirror" training is defined as the first type of training encountered by the participants) on human auditory mirror motor-evoked potentials (MEPs)...
September 22, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29036433/left-ventricular-hypertrophy-predicts-cardiovascular-events-in-hypertensive-patients-with-coronary-artery-calcifications
#14
Chagai Grossman, Michael Levin, Nira Koren-Morag, Gill Bornstein, Avshalom Leibowitz, Ilan Ben-Zvi, Joseph Shemesh, Ehud Grossman
Background: Coronary artery calcification (CAC) is associated with increased cardiovascular (CV) risk. Left ventricular hypertrophy (LVH) is an independent risk factor for CV events. Our aim was to estimate the relative CV risk of LVH in the presence of CAC. Methods: We included asymptomatic hypertensive patients who were enrolled in the calcification arm of the INSIGHT (International Nifedipine Study Intervention as Goal for Hypertension Therapy). Patients had baseline echocardiography and computed tomography (CT) to assess CAC...
October 5, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29036404/the-value-of-prior-knowledge-in-machine-learning-of-complex-network-systems
#15
Dana Ferranti, David Krane, David Craft
Motivation: Our overall goal is to develop machine-learning approaches based on genomics and other relevant accessible information for use in predicting how a patient will respond to a given proposed drug or treatment. Given the complexity of this problem, we begin by developing, testing and analyzing learning methods using data from simulated systems, which allows us access to a known ground truth. We examine the benefits of using prior system knowledge and investigate how learning accuracy depends on various system parameters as well as the amount of training data available...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036305/breeding-for-cuticle-associated-traits-in-crop-species-traits-targets-and-strategies
#16
Johann Petit, Cécile Bres, Jean-Philippe Mauxion, Bénédicte Bakan, Christophe Rothan
Improving crop productivity and quality while promoting sustainable agriculture have become major goals in plant breeding. The cuticle is a natural film covering the aerial organs of plants and consists of lipid polyesters covered and embedded with wax. The cuticle protects plants against water loss and pathogens and affects traits with strong impacts on crop quality such as, for horticultural crops, fruit brightness, cracking, russeting, netting, and shelf life. Here we provide an overview of the most important cuticle-associated traits that can be targeted for crop improvement...
September 27, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29036294/realityconvert-a-tool-for-preparing-3d-models-of-biochemical-structures-for-augmented-and-virtual-reality
#17
Alexandre Borrel, Denis Fourches
Motivation: There is a growing interest for the broad use of Augmented Reality (AR) and Virtual Reality (VR) in the fields of bioinformatics and cheminformatics to visualize complex biological and chemical structures. AR and VR technologies allow for stunning and immersive experiences, offering untapped opportunities for both research and education purposes. However, preparing 3D models ready to use for AR and VR is time-consuming and requires a technical expertise that severely limits the development of new contents of potential interest for structural biologists, medicinal chemists, molecular modellers and teachers...
August 2, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036293/rare-germline-variants-in-known-melanoma-susceptibility-genes-in-familial-melanoma
#18
Alisa M Goldstein, Yanzi Xiao, Joshua Sampson, Bin Zhu, Melissa Rotunno, Hunter Bennett, Yixuan Wen, Kristine Jones, Aurelie Vogt, Laurie Burdette, Wen Luo, Bin Zhu, Meredith Yeager, Belynda Hicks, Jiali Han, Immaculata De Vivo, Stella Koutros, Gabriella Andreotti, Laura Beane-Freeman, Mark Purdue, Neal D Freedman, Stephen J Chanock, Margaret A Tucker, Xiaohong R Yang
Known high-risk cutaneous malignant melanoma (CMM) genes account for melanoma risk in < 40% of melanoma-prone families, suggesting the existence of additional high-risk genes or perhaps a polygenic mechanism involving multiple genetic modifiers. The goal of this study was to systematically characterize rare germline variants in 42 established melanoma genes among 144 CMM patients in 76 American CMM families without known mutations using data from whole-exome sequencing. We identified 68 rare (<0.1% in public and in-house control datasets) nonsynonymous variants in 25 genes...
October 3, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036273/scoop-an-accurate-and-fast-predictor-of-protein-stability-curves-as-a-function-of-temperature
#19
Fabrizio Pucci, Jean Marc Kwasigroch, Marianne Rooman
Motivation: The molecular bases of protein stability remain far from elucidated even though substantial progress has been made through both computational and experimental investigations. One of the most challenging goals is the development of accurate prediction tools of the temperature dependence of the standard folding free energy Δ G ( T ). Such predictors have an enormous series of potential applications, which range from drug design in the biopharmaceutical sector to the optimization of enzyme activity for biofuel production...
June 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036252/efficacy-of-isotretinoin-and-acitretin-in-treatment-of-frontal-fibrosing-alopecia-retrospective-analysis-of-54-cases
#20
Adriana Rakowska, Agnieszka Gradzińska, Małgorzata Olszewska, Lidia Rudnicka
This study aimed to assess the efficacy of systemic retinoids in treating frontal fibrosing alopecia (FFA). It was based on a retrospective analysis of 54 female patients with FFA treated with: oral isotretinoin at the daily dose of 20 mg (29/54) or acitretin at the daily dose of 20 mg (11/54) or with oral finasteride 5 mg/daily (14/54). The study was conducted between 2007 and 2017. The basic of the study is the measurement of distance between the frontal hairline and the glabellar crease prior to the commencement of treatment and after 6, 12, and 24 months...
October 1, 2017: Journal of Drugs in Dermatology: JDD
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