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https://www.readbyqxmd.com/read/29656545/a-framework-for-treating-dsm-5-alternative-model-for-personality-disorder-features
#1
Christopher J Hopwood
Despite its demonstrated empirical superiority over the DSM-5 Section 2 categorical model of personality disorders for organizing the features of personality pathology, limitations remain with regard to the translation of the DSM-5 Section 3 alternative model of personality disorders (AMPD) to clinical practice. The goal of this paper is to outline a general and preliminary framework for approaching treatment from the perspective of the AMPD. Specific techniques are discussed for the assessment and treatment of both Criterion A personality dysfunction and Criterion B maladaptive traits...
April 15, 2018: Personality and Mental Health
https://www.readbyqxmd.com/read/29656508/the-3-rd-world-conference-on-kisspeptin-kisspeptin-2017-brain-and-beyond-unresolved-questions-challenges-and-future-directions-for-the-field
#2
REVIEW
Michael N Lehman, Lique M Coolen, Robert A Steiner, Genevieve Neal-Perry, Luhong Wang, Suzanne M Moenter, Aleisha M Moore, Robert L Goodman, Shel Hwa-Yeo, Stephanie L Padilla, Alexander S Kauffman, James Garcia, Martin J Kelly, Jenny Clarkson, Sally Radovick, Andy V Babwah, Silvia Leon, Manuel Tena-Sempere, Alex Comninos, Stephanie Seminara, Waljit S Dhillo, Jon Levine, Ei Terasawa, Ariel Negron, Allan E Herbison
The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond" was held March 30-31 at the Rosen Centre Hotel in Orlando, Florida, providing an international forum for multidisciplinary scientists to meet and share cutting-edge research on kisspeptin biology and its relevance to human health and disease. The meeting built upon previous world conferences focused on the role of kisspeptin and associated peptides in the control of gonadotropin-releasing hormone (GnRH) secretion and reproduction...
April 14, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29656461/applicability-of-internet-search-index-for-asthma-admission-forecast-using-machine-learning
#3
Li Luo, Chengcheng Liao, Fengyi Zhang, Wei Zhang, Chunyang Li, Zhixin Qiu, Debin Huang
OBJECTIVE: This study aimed to determine whether a search index could provide insight into trends in asthma admission in China. An Internet search index is a powerful tool to monitor and predict epidemic outbreaks. However, whether using an internet search index can significantly improve asthma admissions forecasts remains unknown. The long-term goal is to develop a surveillance system to help early detection and interventions for asthma and to avoid asthma health care resource shortages in advance...
April 15, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29656428/aggregation-and-conformational-changes-of-silver-carp-myosin-as-affected-by-ultrasound-calcium-combination-system
#4
Yueqi An, Qing Liu, Yaru Xie, Shanbai Xiong, Tao Yin, Ru Liu
BACKGROUND: Ultrasound and Ca2+ have been used separately to increase myosin properties in fish processing. However, little literature was found about myosin changes affected by Ca2+ and ultrasound in combination. The goal of this study was to investigate the effects of ultrasound-calcium combination system on aggregation and conformational changes of silver carp myosin. RESULTS: Ultrasonic facilitated the Ca2+ -induced increase of turbidity. As Ca2+ concentration increased from 0 to 100 mmol L-1 , there was an obvious increase in the turbidity, solubility and mean hydrated particle size of myosin after ultrasonic treatment compared to those without ultrasonic...
April 15, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29656324/the-organic-pollutant-status-of-rivers-in-bosnia-and-herzegovina-as-determined-by-a-combination-of-active-and-passive-sampling-methods
#5
Christopher Harman, Merete Grung, Jasmina Djedjibegovic, Aleksandra Marjanovic, Eirik Fjeld, Hans Fredrik Veiteberg Braaten, Miroslav Sober, Thorjørn Larssen, Sissel Brit Ranneklev
There is an overall lack of data concerning the pollution status of Bosnia Herzegovina, which is confounded by fragmented national environmental management. The present study aimed to provide some initial data for concentrations of priority substances in two major Bosnian Rivers, using two types of passive sampler (PS) as well as by using high volume water sampling (HVWS). Overall, concentrations of most persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and legacy pesticides, were shown to be low...
April 15, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29656323/study-of-carbon-nanotube-rich-impedimetric-recognition-electrode-for-ultra-low-determination-of-polycyclic-aromatic-hydrocarbons-in-water
#6
Jose Muñoz, Cristina Navarro-Senent, Nuria Crivillers, Marta Mas-Torrent
Carbon nanotubes (CNTs) have been studied as an electrochemical recognition element for the impedimetric determination of priority polycyclic aromatic hydrocarbons (PAHs) in water, using hexocyanoferrate as a redox probe. For this goal, an indium tin oxide (ITO) electrode functionalized with a silane-based self-assembled monolayer carrying CNTs has been engineered. The electroanalytical method, which is similar to an antibody-antigen assay, is straightforward and exploits the high CNT-PAH affinity obtained via π-interactions...
April 14, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29656293/what-does-it-need-to-improve-nutrition-quality-the-role-of-public-partners
#7
Hanns-Christoph Eiden
Public partners play a key role when we want to improve nutrition quality. They will not succeed, when they try to achieve the goal alone or tend to dominate other players. In their responsibility for common interests it is up to public partners to moderate and facilitate the multi-stakeholder and multi-sectorial dialogue to improve nutrition quality. It is up to public partners to establish clear legal and structural guidelines aiming to bring all partners together, to avoid conflicts of interests and, above all, establish conditions, in which consumers are sufficiently informed about food and nutrition, so that they are motivated, empowered, and adequately protected to take their own responsible decisions...
April 13, 2018: World Review of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29656138/impdh-pharmacogenetics-in-hematopoietic-cell-transplantation-patients
#8
Jeannine S McCune, Barry Storer, Sushma Thomas, Jožefa McKiernan, Rohan Gupta, Brenda M Sandmaier
We evaluated inosine monophosphate dehydrogenase (IMPDH) 1 and IMPDH2 pharmacogenetics in 247 recipient-donor pairs after nonmyeloablative hematopoietic cell transplant (HCT) recipients. Patients were conditioned with total body irradiation + fludarabine, received grafts from related or unrelated donors (10% HLA mismatch), with post-graft immunosuppression of mycophenolate mofetil (MMF) with a calcineurin inhibitor. Recipient and donor IMPDH genotype (rs11706052, rs2278294, rs2278293) were not associated with day 28 T-cell chimerism, acute graft versus host disease, disease relapse, cytomegalovirus reactivation, non-relapse mortality, or overall survival...
April 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29656051/the-private-journey-an-interpretative-phenomenological-analysis-of-exclusive-breastfeeding
#9
Samantha J Charlick, Lois McKellar, Andrea L Gordon, Jan Pincombe
BACKGROUND: Exclusive breast milk provides complete nutrition for a baby's first six months of life. In Australia, breastfeeding initiation rates are high, however duration rates are low. Although numerous studies have explored the reasons behind low levels of breastfeeding, few have examined the experiences of women who maintain exclusive breastfeeding for the recommended six-month duration. AIM: This paper will present an in-depth, idiographic interpretation of first-time mothers' experience of exclusive breastfeeding for six months in Australia...
April 11, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29655901/in-vivo-heterotopic-culturing-of-prefabricated-tendon-grafts-with-mechanical-stimulation-in-a-sheep-model
#10
M Petri, P Lu, M Omar, M Ettinger, C Krettek, C Neunaber, M Jagodzinski
BACKGROUND: The goal of this study is to investigate the biomechanical and histological properties of in vivo heterotopically prefabricated cruciate ligament replacement grafts with and without mechanical stimulation. The clinical goal is to heterotopically prefabricate a bone-tendon-bone graft for anterior cruciate ligament reconstruction, which allows rapid ingrowth and early full weight bearing. METHODS: In a sheep model, eight quadriceps tendon grafts were harvested and introduced into culture chambers at their proximal and distal ends...
April 11, 2018: Knee
https://www.readbyqxmd.com/read/29655861/age-related-changes-in-urinary-flow-following-dorsal-inlay-graft-urethroplasty-for-hypospadias-in-early-childhood-potential-improvement-over-11-years-of-age
#11
Woo Jin Kim, Chihiro Hayashi, Yuichiro Yamazaki
INTRODUCTION: One of the goals of hypospadias repair is to create a neourethra with normal urinary stream and normal growth. Several studies have reported that dorsal inlay graft urethroplasty (DIG) has wide indications for various clinical phenotypes of hypospadias, with good short-term outcomes and few complications. However, there have been no reports that evaluated both short-term and long-term functional outcomes using uroflowmetry in patients with DIG. OBJECTIVE: The aim was to investigate whether uroflowmetry parameters change with time following DIG for hypospadias in early childhood...
March 23, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29655859/rescuing-cognitive-and-emotional-regulatory-skills-to-aid-smoking-prevention-in-at-risk-youth-a-randomized-trial
#12
Michael W Otto, Eugenia I Gorlin, David Rosenfield, Elijah A Patten, Warren K Bickel, Michael J Zvolensky, Stacey N Doan
Adolescence is a vulnerable period for smoking initiation, with disadvantaged teens particularly at risk. In addition, emotional and cognitive dysregulation is associated with an increased risk of smoking and makes it particularly challenging to benefit from standard substance use prevention interventions. The goal of the current study is to investigate the extent to which interventions designed to improve cognitive (working memory) and emotional (distress tolerance) regulatory processes enhance the effectiveness of a standard smoking prevention informational intervention...
April 12, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29655825/hypertrophic-cardiomyopathy-clinical-update
#13
REVIEW
Jeffrey B Geske, Steve R Ommen, Bernard J Gersh
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopathy, manifesting as left ventricular hypertrophy in the absence of a secondary cause. The genetic underpinnings of HCM arise largely from mutations of sarcomeric proteins; however, the specific underlying mutation often remains undetermined. Patient presentation is phenotypically diverse, ranging from asymptomatic to heart failure or sudden cardiac death. Left ventricular hypertrophy and abnormal ventricular configuration result in dynamic left ventricular outflow obstruction in most patients...
April 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29655800/effects-of-task-complexity-and-age-differences-on-task-related-functional-connectivity-of-attentional-networks
#14
Margaret A O'Connell, Chandramallika Basak
Studies investigating the strength and membership of regions within multiple functional networks primarily focus on either resting state or single cognitive tasks. The goals of the current study were to investigate whether task-related functional connectivity changes with task complexity, and whether this connectivity-complexity relationship is age-sensitive. We assessed seed-to-voxel functional connectivity for the default mode network (DMN) and two attentional networks [cingulo-opercular (CO), fronto-parietal (FP)] in three cognitive control tasks of increasing complexity (Single task, Dual task, and Memory Updating), across younger and older adults (N=52; NYoung =23; NOld =29)...
April 12, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29655714/the-influence-of-food-matrices-on-aptamer-selection-by-selex-systematic-evolution-of-ligands-by-exponential-enrichment-targeting-the-norovirus-p-domain
#15
Katja B Schilling, Jeffrey DeGrasse, Jacquelina W Woods
This study investigates the enrichment of aptamers targeting the norovirus protruding domain in the presence of foods often associated with norovirus outbreaks. The goal is to explore if and how the presence of food alters in vitro selection of aptamers and target binding of the enriched oligonucleotides. Our study demonstrates that the introduction of food to SELEX (systematic evolution of ligands by exponential enrichment) is either detrimental to enrichment of oligonucleotides with target-specific binding, or facilitates enrichment of non-target-specific oligonucleotides...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29655694/tatanan-a-from-the-acorus-calamus-l-root-inhibited-dengue-virus-proliferation-and-infections
#16
Xingang Yao, Yun Ling, Songxin Guo, Wenyu Wu, Shijun He, Qing Zhang, Min Zou, Kutty Selva Nandakumar, Xiaoguang Chen, Shuwen Liu
BACKGROUND: Acorus calamus l. (Acoraceae) is a well-known traditional Chinese medicinal plant, whose root are historically mainly used to treat neurodegenerative diseases, and for cholera treatment. This datum strongly indicates the antimicrobial activity of A. calamus. PURPOSE: Our goal is to find the active constituents of A. calamus to treat dengue virus (DENV) infections, and to study the effects and mechanisms of these active substances. METHODS: The root of A...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655682/pristimerin-a-naturally-occurring-triterpenoid-attenuates-tumorigenesis-in-experimental-colitis-associated-colon-cancer
#17
Ju-Hyung Park, Jin-Kyung Kim
BACKGROUND: Pristimerin is a quinonemethide triterpenoid with anti-cancer, anti-angiogenic, anti-inflammatory and anti-protozoal activity. However, the therapeutic role of pristimerin in colitis-associated colorectal carcinogenesis is unknown. PURPOSE: We sought to examine the therapeutic effects of pristimerin on colitis-associated colon cancer induced in mice using azoxymethane (AOM)/dextran sulfate sodium (DSS). The goal was to identify the potential mechanism of action underlying the pharmacological activity of pristimerin...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655662/evaluation-of-low-intensity-anti-coagulation-with-a-fully-magnetically-levitated-centrifugal-flow-circulatory-pump-the-magentum-1-study
#18
Ivan Netuka, Peter Ivák, Zuzana Tučanová, Stanislav Gregor, Ondrej Szárszoi, Poornima Sood, Daniel Crandall, Jessica Rimsans, Jean Marie Connors, Mandeep R Mehra
BACKGROUND: The HeartMate 3 left ventricular assist system is engineered to avoid pump thrombosis, yet bleeding complications persist. We investigated the safety of low-intensity anti-coagulation in patients with the HeartMate 3. METHODS: The Minimal AnticoaGulation EvaluatioNTo aUgment heMocompatibility (MAGENTUM 1) pilot study is a prospective, single-arm study of low-intensity warfarin anti-coagulation in patients implanted with the HeartMate 3 pump. After standard warfarin anti-coagulation (international normalized ratio [INR] 2...
March 27, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29655623/insulin-resistance-and-metabolic-syndrome-criteria-in-lean-normoglycemic-college-age-subjects
#19
Dana K Townsend, Katheryn McGregor, Esther Wu, Kathryn Cialkowski, Mark D Haub, Thomas J Barstow
AIMS: The goal of this study was to determine insulin sensitivity in a fasted state and during an oral glucose tolerance test (OGTT), in normoglycemic (NGT), lean (L) (n = 35) and, for comparison, overweight/obese (OW/O) (n = 9) college-aged subjects. MATERIALS AND METHODS: Insulin sensitivity for 44 NGT, normotensive subjects, age 18-26 yrs., was determined by homeostasis model assessment (HOMA-IR) and from Matsuda index (ISI Matsuda). RESULTS: Subjects were normoglycemic fasted (4...
March 31, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29655614/a-brief-validated-screen-to-identify-boys-and-girls-at-risk-for-early-marijuana-use
#20
Rolf Loeber, Duncan B Clark, Lia Ahonen, Douglas FitzGerald, Elisa M Trucco, Robert A Zucker
To guide recruitment, the ABCD Study requires a method for identifying children at high risk for early-onset substance use that may be utilized during the recruitment process. This study was undertaken to inform the development of a brief screen for identifying youths' risk of early-onset substance use and other adverse outcomes. To be acceptable by participants in this context, consideration of potential items was limited to child characteristics previously determined to be potentially pertinent and parental cigarette smoking...
April 7, 2018: Developmental Cognitive Neuroscience
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