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Cancer breast pregnancy

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https://www.readbyqxmd.com/read/28911214/growth-regulation-by-estrogen-in-breast-cancer-1-greb1-is-a-novel-progesterone-responsive-gene-required-for-human-endometrial-stromal-decidualization
#1
Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani
STUDY QUESTION: Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? SUMMARY ANSWER: GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. WHAT IS KNOWN ALREADY: Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28894854/the-relationship-between-breast-cancer-and-risk-factors-a-single-center-study
#2
Arzu Ozsoy, Nurdan Barca, Betul Akdal Dolek, Hafize Aktaş, Eda Elverici, Levent Araz, Ozlen Ozkaraoğlu
OBJECTIVE: To determine the relationship between breast cancer and known risk factors in patients who had mammography (MG) for breast cancer screening or ultrasonography and/or MG for diagnostic purposes. MATERIALS AND METHODS: In the period of January-December, 2011, a questionnaire composed of 17 questions was applied to 2862 female patients and MG and/or US examination was performed afterwards. Chi-square and Kruskal-Wallis tests were used for statistical analysis...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28880981/timing-of-pregnancy-and-survival-in-women-with-breast-cancer
#3
Samer Al Hadidi
No abstract text is available yet for this article.
September 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28878901/breast-reconstruction-in-pregnancy-a-case-report-of-multidisciplinary-team-approach-in-immediate-autologous-flap-reconstruction-for-pregnancy-associated-breast-cancer
#4
Prakasit Chirappapha, Panya Thaweepworadej, Nuttapong Ngamphaiboon, Matchuporn Sukprasert, Thongchai Sukarayothin, Monchai Leesombatpaiboon
This report presents the results of immediate breast reconstruction with autologous flap in Pregnancy-associated breast cancer (PABC). There was no obstetrics and surgical complications in our report. Immediate breast reconstruction can be performed in PABC after a careful selection. Multidisciplinary team approach is the key in managing these groups of patients.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28874690/a-single-neonatal-administration-of-bisphenol-a-induces-higher-tumour-weight-associated-to-changes-in-tumour-microenvironment-in-the-adulthood
#5
Margarita Isabel Palacios-Arreola, Karen Elizabeth Nava-Castro, Víctor Hugo Del Río-Araiza, Nashla Yazmín Pérez-Sánchez, Jorge Morales-Montor
BPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. Neonate (PND 3) female syngeneic BALB/c mice were exposed to a single dose of 250 µg/kg BPA. Once sexual maturity was reached, a mammary tumour was induced injecting 4T1 cells in situ, these cells are derived from a spontaneous adenocarcinoma in a BALB/c mouse and therefore allows for an immunocompetent recipient...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28858975/development-and-validation-of-a-fertility-intention-scale-in-breast-cancer-survivors
#6
Chin-Ching Li, Sheng-Miauh Huang, Jerry Cheng-Yen Lai, Yvonne Hsiung, Yi-Heng Chen, Ching-Fang Lee
BACKGROUND: Evidence indicates that breast cancer survivors with reproductive concerns have a poorer quality of life than survivors without fertility concerns. There is a lack of reliable and valid assessments of fertility intention among breast cancer survivors. PURPOSE: The aim of this study was to develop and validate the Fertility Intention Scale (FIS) that is sensitive to the fertility intention of women with breast cancer. METHODS: A literature review and a qualitative study were conducted to generate the items in the scale...
August 31, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28851667/estrogen-and-progesterone-signalling-in-the-normal-breast-and-its-implications-for-cancer-development
#7
REVIEW
Heidi N Hilton, Christine L Clarke, J Dinny Graham
The ovarian hormones estrogen and progesterone are master regulators of the development and function of a broad spectrum of human tissues, including the breast, reproductive and cardiovascular systems, brain and bone. Acting through the nuclear estrogen (ER) and progesterone receptors (PR), both play complex and essential coordinated roles in the extensive development of the lobular alveolar epithelial structures of the normal breast during puberty, the normal menstrual cycle and pregnancy. The past decade has seen major advances in understanding the mechanisms of action of estrogen and progesterone in the normal breast and in the delineation of the complex hierarchy of cell types regulated by ovarian hormones in this tissue...
August 26, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28836277/the-risk-of-preterm-birth-and-growth-restriction-in-pregnancy-after-cancer
#8
Kathleen P Hartnett, Kevin C Ward, Michael R Kramer, Timothy L Lash, Ann C Mertens, Jessica B Spencer, Amy Fothergill, Penelope P Howards
It is unclear whether cancer and its treatments increase the risk of adverse pregnancy outcomes. Our aim was to examine whether cancer survivors have higher risks of poor outcomes in pregnancies conceived after diagnosis than women without cancer, and whether these risks differ by cancer type and race. Diagnoses from cancer registries were linked to pregnancy outcomes from birth certificates in three U.S. states. Analyses were limited to the first, live singleton birth conceived after diagnosis. Births to women without a previous cancer diagnosis in the registry were matched to cancer survivors on age at delivery, parity, race/ethnicity and education...
August 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28828694/association-between-mammographic-density-and-pregnancies-relative-to-age-and-bmi-a-breast-cancer-case-only-analysis
#9
Carolin C Hack, Julius Emons, Sebastian M Jud, Katharina Heusinger, Werner Adler, Paul Gass, Lothar Haeberle, Felix Heindl, Alexander Hein, Rüdiger Schulz-Wendtland, Michael Uder, Arndt Hartmann, Matthias W Beckmann, Peter A Fasching, Uwe G Pöhls
PURPOSE: Percentage mammographic density (PMD) is a major risk factor for breast cancer (BC). It is strongly associated with body mass index (BMI) and age, which are themselves risk factors for breast cancer. This analysis investigated the association between the number of full-term pregnancies and PMD in different subgroups relative to age and BMI. METHODS: Patients were identified in the breast cancer database of the University Breast Center for Franconia. A total of 2410 patients were identified, for whom information on parity, age, and BMI, and a mammogram from the time of first diagnosis were available for assessing PMD...
August 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28827141/estetrol-a-fetal-selective-estrogen-receptor-modulator-acts-on-the-vagina-of-mice-through-nuclear-er%C3%AE-activation
#10
Thibaut Benoit, Marie-Cecile Valera, Coralie Fontaine, Melissa Buscato, Francoise Lenfant, Isabelle Raymond-Letron, Florence Tremollieres, Michel Soulie, Jean-Michel Foidart, Xavier Game, Jean-Francois Arnal
The genito-urinary syndrome of menopause has a negative impact on quality of life of postmenopausal women. The treatment of vulvo-vaginal atrophy (VVA) includes administration of estrogens. However, oral estrogen treatment is controversial due to its potential risks on venous thrombosis and breast cancer. Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver and initially considered as a weak estrogen. However, E4 was recently evaluated in a phase I-II clinical studies and found to act as an oral contraceptive in combination with a progestin, without increasing the level of coagulation factors...
August 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28826374/coffee-caffeine-and-health-outcomes-an-umbrella-review
#11
Giuseppe Grosso, Justyna Godos, Fabio Galvano, Edward L Giovannucci
To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes...
August 21, 2017: Annual Review of Nutrition
https://www.readbyqxmd.com/read/28822014/functional-igf1r-variant-predicts-breast-cancer-risk-in-women-with-preeclampsia-in-california-teachers-study
#12
Mark J Powell, Julie Von Behren, Susan Neuhausen, Peggy Reynolds, Christopher C Benz
PURPOSE: Hypertension in pregnancy has been associated with decreased future risk of breast cancer in many but not all studies. In the Marin Women's Study, pregnancy-induced hypertension was shown to interact with the T allele of a functional IGF1R gene variant, rs2016347, to result in lower breast density, as well as decreased breast cancer risk. Our objective was to explore these findings in a larger sample of women from the California Teachers Study (CTS). METHODS: The CTS cohort consists of over 130,000 female educators...
August 18, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#13
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
August 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28798811/pregnancy-testing-in-patients-undergoing-radiation-therapy
#14
Shivam M Kharod, Julie Greenwalt, Camille Dessaigne, Anamaria Yeung
Radiation therapy (RT) can be lethal to a developing fetus; therefore, determining pregnancy status before RT is essential. We here sought to determine how many women treated with RT at our institution for over one year were at risk for pregnancy when starting RT. We retrospectively reviewed the medical records of all female patients 12-55 years old treated with radiation, i.e. 1 October 2012 to 31 September 2013. Patients were categorised as 'at risk' if they had a uterus and 'no risk' if they had a hysterectomy...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28797766/pregnancy-outcomes-after-a-breast-cancer-diagnosis-a-systematic-review-and-meta-analysis
#15
REVIEW
Brigitte Gerstl, Elizabeth Sullivan, Angela Ives, Christobel Saunders, Handan Wand, Antoinette Anazodo
Improvements in local and systemic treatment, along with earlier diagnoses through breast awareness and screening, have led to increases in survival and a decline in breast cancer (BC) recurrence. To the best of our knowledge, no meta-analysis has yet focused on pregnancy outcomes after BC treatment. Hence, our research group explored the reproductive outcomes (pregnancy, miscarriage, termination of pregnancy, live births) after BC treatment. The Embase, MEDLINE, PubMed, and Scopus databases were searched. Studies were included that reported on pregnancy and reproductive outcomes after treatment of BC...
July 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28790868/contraception-concerns-utilization-and-counseling-needs-of-women-with-a-history-of-breast-cancer-a-qualitative-study
#16
Sheila K Mody, Danielle M Panelli, Avanthi Hulugalle, H Irene Su, Jessica R Gorman
INTRODUCTION: Reproductive-aged women who have had breast cancer face unique challenges when it comes to making decisions about contraception. Clinical guidelines indicate that patients should avoid pregnancy during cancer treatment, however the extent of contraception counseling and utilization after diagnosis has not been well studied. METHODS: We conducted three focus groups and one semi-structured interview with women between the ages of 18 and 50 years old diagnosed with breast cancer within the last 5 years...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28770179/risk-factors-for-breast-cancer-in-gaza-strip-palestine-a-case-control-study
#17
Mueen Kariri, Marwan O Jalambo, Basil Kanou, Saleh Deqes, Samaher Younis, Baker Zabut, Usama Balawi
Breast cancer (BC) is the main common cause of cancer mortality among women in the world. This study aims at investigating BC epidemiology and identifying the different risk factors associated and the most affecting ones among women in the Gaza Strip, Palestine. This study was a hospital-based case-control (1:2), as the study was carried out over the period of October 2014 to February 2015. A total of 105 BC patients, chosen from Al-Shifa Hospital in Gaza City and European hospital for the south governorate, were the case and compared to 209 women as a control group who matched the cases in age, residence, and with no history of breast problems...
July 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28756339/whole-body-mri-for-systemic-staging-of-breast-cancer-in-pregnant-women
#18
Fedro A Peccatori, Giovanni Codacci-Pisanelli, Maria Del Grande, Giovanna Scarfone, Fabio Zugni, Giuseppe Petralia
When breast cancer is diagnosed during pregnancy, treatment should be as close; as possible to what is used in non-pregnant patients. This requires accurate local and systemic staging: ultrasound (US) is used for local staging and allows adequate evaluation of the liver and pelvis, but chest and bones cannot be explored and imaging techniques involving exposure to ionizing radiation would be needed. However, since imaging techniques involving ionizing radiation and the use of radionuclides should be limited, whole body magnetic resonance imaging (WB-MRI) without administration of contrast agent represents a very interesting alternative, but limited data is available...
October 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28754015/human-chorionic-gonadotropin-and-breast-cancer
#19
REVIEW
Susanne Schüler-Toprak, Oliver Treeck, Olaf Ortmann
Breast cancer is well known as a malignancy being strongly influenced by female steroids. Pregnancy is a protective factor against breast cancer. Human chorionic gonadotropin (HCG) is a candidate hormone which could mediate this antitumoral effect of pregnancy. For this review article, all original research articles on the role of HCG in breast cancer were considered, which are listed in PubMed database and were written in English. The role of HCG in breast cancer seems to be a paradox. Placental heterodimeric HCG acts as a protective agent by imprinting a permanent genomic signature of the mammary gland determining a refractory condition to malignant transformation which is characterized by cellular differentiation, apoptosis and growth inhibition...
July 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28750297/fertility-and-pregnancy-issues-in-brca-mutated-breast-cancer-patients
#20
REVIEW
Matteo Lambertini, Oranite Goldrat, Angela Toss, Hatem A Azim, Fedro A Peccatori, Michail Ignatiadis, Lucia Del Mastro, Isabelle Demeestere
Fertility and pregnancy-related issues represent one of the main areas of concerns for young women with breast cancer. Carrying a germline deleterious BRCA mutation adds additional burden on this regard due to the specific issues that should be considered during the oncofertility counseling of this special patient group. Despite the availability of a growing amount of data in the general breast cancer population on the feasibility and safety of fertility preservation and pregnancy after diagnosis, numerous challenges remain for BRCA-mutated breast cancer patients in whom very limited studies have been performed so far...
September 2017: Cancer Treatment Reviews
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