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https://www.readbyqxmd.com/read/27894063/loss-of-glutaredoxin-3-impedes-mammary-lobuloalveolar-development-during-pregnancy-and-lactation
#1
Khanh Pham, Jie Dong, Xiqian Jiang, Ying Qu, Han Yu, Yisheng Yang, Walter Olea, Juan C Marini, Lawrence Chan, Jin Wang, Xander H T Wehrens, Xiaojiang Cui, Yi Li, Darryl L Hadsell, Ninghui Cheng
Mammalian glutaredoxin 3 (Grx3) has been shown to be important for regulating cellular redox homeostasis in the cell. Our previous studies indicate that Grx3 is significantly overexpressed in various human cancers including breast cancer and demonstrate that Grx3 controls cancer cell growth and invasion by regulating ROS and NF-κB signaling pathways. However, it remains to be determined whether Grx3 is required for normal mammary gland development and how it contributes to epithelial cell proliferation and differentiation in vivo In the present study, we examined Grx3 expression in different cell types within the developing mouse mammary gland (MG) and found enhanced expression of Grx3 at pregnancy and lactation stages...
November 15, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27892674/the-investigation-of-risk-factors-impacting-breast-cancer-in-guilan-province
#2
Farahnaz Joukar, Zahra Ahmadnia, Zahra Atrkar-Roushan, Farideh Hasavari, Abbas Rahimi
Introduction: Breast cancer is multifactorial therefore more recognition of risk factors is important in its prevention. Objective: This study was conducted in order to determine the factors influencing breast cancer in women referred to health centers in Guilan province in 2015-2016. Method: In a case- control study, 225 women with breast cancer were investigated. The control group consisted of 225 healthy women of the relatives (third-rank) whose phone numbers were obtained from the patients. Data were collected through telephone interviews...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27884590/physical-activity-induced-protection-against-breast-cancer-risk-associated-with-delayed-parity
#3
Kathleen M Sturgeon, Aaron Schweitzer, John J Leonard, Deirdre K Tobias, Ying Liu, Elizabeth Cespedes Feliciano, Vasanti S Malik, Amit Joshi, Bernard Rosner, Bart C De Jonghe
Epidemiological evidence indicates that physical activity between menarche and first pregnancy is associated with a lower risk of breast cancer among women with at least 20years between these reproductive events. The mechanism by which physical activity during this interval confers protection is unknown. This study used a novel animal model to assess potentially protective effects of physical activity on tumor development in delayed parity. Thirty-six female Sprague Dawley rats received an i.p. injection of 50mg/kg N-methyl-N-nitrosourea (MNU) at 5weeks of age...
November 21, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27881737/rankl-rank-from-bone-loss-to-the-prevention-of-breast-cancer
#4
REVIEW
Verena Sigl, Laundette P Jones, Josef M Penninger
RANK and RANKL, a receptor ligand pair belonging to the tumour necrosis factor family, are the critical regulators of osteoclast development and bone metabolism. Besides their essential function in bone, RANK and RANKL have also been identified as the key factors for the formation of a lactating mammary gland in pregnancy. Mechanistically, RANK and RANKL link the sex hormone progesterone with stem cell expansion and proliferation of mammary epithelial cells. Based on their normal physiology, RANKL/RANK control the onset of hormone-induced breast cancer through the expansion of mammary progenitor cells...
November 2016: Open Biology
https://www.readbyqxmd.com/read/27880720/the-impact-of-reproductive-life-on-breast-cancer-risk-in-women-with-family-history-or-brca-mutation
#5
Angela Toss, Giovanni Grandi, Angelo Cagnacci, Luigi Marcheselli, Silvia Pavesi, Elisabetta De Matteis, Elisabetta Razzaboni, Chiara Tomasello, Stefano Cascinu, Laura Cortesi
Reproductive history and exogenous hormonal exposures are acknowledged risk factors for breast cancer in the general population. In women at increased breast cancer risk for genetic predisposition or positive family history, data regarding these risk factors are limited or conflicting, and recommendations for these categories are unclear. We evaluated the characteristics of reproductive life in 2522 women at increased genetic or familial breast cancer risk attending our Family Cancer Center. Breast cancers in BRCA mutation carriers were more likely to be hormone receptor negative, diagnosed at 35 years or before and multiple during the lifetime than tumors in women at increased familial risk, while the distribution of invasive cancers and HER2 positive tumors was similar in the different risk groups...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27845421/rs2735383-located-at-a-microrna-binding-site-in-the-3-utr-of-nbs1-is-not-associated-with-breast-cancer-risk
#6
Jingjing Liu, Ivona Lončar, J Margriet Collée, Manjeet K Bolla, Joe Dennis, Kyriaki Michailidou, Qin Wang, Irene L Andrulis, Monica Barile, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Carl Blomqvist, Bram Boeckx, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Jenny Chang-Claude, Shou-Tung Chen, Georgia Chenevix-Trench, Ching Y Cheng, Ji-Yeob Choi, Fergus J Couch, Angela Cox, Simon S Cross, Katarina Cuk, Kamila Czene, Thilo Dörk, Isabel Dos-Santos-Silva, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Graham G Giles, Gord Glendon, Mark S Goldberg, Anna González-Neira, Pascal Guénel, Christopher A Haiman, Ute Hamann, Steven N Hart, Mikael Hartman, Sigrid Hatse, John L Hopper, Hidemi Ito, Anna Jakubowska, Maria Kabisch, Daehee Kang, Veli-Matti Kosma, Vessela N Kristensen, Loic Le Marchand, Eunjung Lee, Jingmei Li, Artitaya Lophatananon, Jan Lubinski, Arto Mannermaa, Keitaro Matsuo, Roger L Milne, Susan L Neuhausen, Heli Nevanlinna, Nick Orr, Jose I A Perez, Julian Peto, Thomas C Putti, Katri Pylkäs, Paolo Radice, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Andreas Schneeweiss, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Jacques Simard, Melissa C Southey, Anthony Swerdlow, Soo H Teo, Daniel C Tessier, Somchai Thanasitthichai, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Celine Vachon, Robert Winqvist, Anna H Wu, Drakoulis Yannoukakos, Wei Zheng, Per Hall, Alison M Dunning, Douglas F Easton, Maartje J Hooning, Ans M W van den Ouweland, John W M Martens, Antoinette Hollestelle
NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27843602/cancer-in-pregnancy-disentangling-treatment-modalities
#7
REVIEW
Flora Zagouri, Constantine Dimitrakakis, Spyridon Marinopoulos, Alexandra Tsigginou, Meletios-Athanassios Dimopoulos
Pregnancy-associated cancer constitutes an uncommon and difficult to manage clinical situation. It is defined as the cancer diagnosed from the first day of childbearing to 1 year post partum. Coexistence of cancer with pregnancy adds complexity to treatment recommendations, as both the mother and the fetus may be affected. The optimal therapeutic management of pregnant women with cancer diagnosis should take into account, apart from medical factors, a host of other parameters (ethical, psychological, religious, legal, etc)...
2016: ESMO Open
https://www.readbyqxmd.com/read/27833901/potential-mechanisms-underlying-the-protective-effect-of-pregnancy-against-breast-cancer-a-focus-on-the-igf-pathway
#8
REVIEW
Tiffany A Katz
A first full-term birth at an early age protects women against breast cancer by reducing lifetime risk by up to 50%. The underlying mechanism resulting in this protective effect remains unclear, but many avenues have been investigated, including lobular differentiation, cell fate, and stromal composition. A single pregnancy at an early age protects women for 30-40 years, and this long-term protection is likely regulated by a relatively stable yet still modifiable method, such as epigenetic reprograming. Long-lasting epigenetic modifications have been shown to be induced by pregnancy and to target the IGF pathway...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27832451/expression-data-analysis-for-the-identification-of-potential-biomarker-of-pregnancy-associated-breast-cancer
#9
Raja Rajeswary Thanmalagan, Leimarembi Devi Naorem, Amouda Venkatesan
Breast cancer affects every 1 of 3000 pregnant women or in the first post-partum year is referred as Pregnancy Associated Breast Cancer (PABC) in mid 30s. Even-though rare disease, classified under hormone receptor negative status which metastasis quickly to other parts by extra cellular matrix degradation. Hence it is important to find an optimal treatment option for a PABC patient. Also additional care should be taken to choose the drug; in order to avoid fetal malformation and post-partum stage side-effects...
November 10, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27824662/no-association-of-reproductive-risk-factors-with-breast-cancer-tumor-grade
#10
Sahana Somasegar, Li Li, Cheryl L Thompson
Histological tumor grade is a well-established marker of breast tumor aggressiveness and prognosis. A number of reproductive factors, including parity and age at first birth, have been shown to be related to breast cancer risk, but few studies have examined the association of these variables with breast cancer aggressiveness. In this study, 813 newly diagnosed breast cancer patients were surveyed for demographic and lifestyle characteristics. Tumor grade and other clinical variables were abstracted from medical records...
November 7, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27812519/in-depth-medical-nutrition-therapy-for-a-woman-with-diabetes-from-pregnancy-to-delivery
#11
Miyoung Jang, Dal Lae Ju, MeeRa Kweon, Misun Park
Diabetes in pregnancy is associated with higher rates of miscarriage, pre-eclampsia, preterm labor, and fetal malformation. To prevent these obstetric and perinatal complications, women with diabetes have to control levels of blood sugar, both prior to and during pregnancy. Thus, individualized medical nutrition therapy for each stage of pregnancy is essential. We provided in-depth medical nutrition therapy to a 38-year-old pregnant woman with diabetes at all stages of pregnancy up to delivery. She underwent radiation therapy after surgery for breast cancer and was diagnosed with diabetes...
October 2016: Clinical Nutrition Research
https://www.readbyqxmd.com/read/27809299/the-v-atpase-a2-isoform-controls-mammary-gland-development-through-notch-and-tgf-%C3%AE-signaling
#12
Sahithi Pamarthy, Liquin Mao, Gajendra K Katara, Sara Fleetwood, Arpita Kulshreshta, Alice Gilman-Sachs, Kenneth D Beaman
Among all tissues and organs, the mammary gland is unique because most of its development occurs in adulthood. Notch signaling has a major role in mammary gland development and has been implicated in breast cancer. The vacuolar-ATPase (V-ATPase) is a proton pump responsible for the regulation and control of pH in intracellular vesicles and the extracellular milieu. We have previously reported that a2V-ATPase (a2V), an isoform of 'a' subunit of V-ATPase, regulates processing of Notch receptor and alters Notch signaling in breast cancer...
November 3, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27808166/lpa-receptor-activity-is-basal-specific-and-coincident-with-early-pregnancy-and-involution-during-mammary-gland-postnatal-development
#13
Deanna Acosta, Susmita Bagchi, Pilib Ó Broin, Daniel Hollern, Silvia E Racedo, Bernice Morrow, Rani S Sellers, John M Greally, Aaron Golden, Eran Andrechek, Teresa Wood, Cristina Montagna
During pregnancy, luminal and basal epithelial cells of the adult mammary gland proliferate and differentiate resulting in remodeling of the adult gland. While pathways that control this process have been characterized in the gland as a whole, the contribution of specific cell subtypes, in particular the basal compartment, remains largely unknown. Basal cells provide structural and contractile support, however they also orchestrate the communication between the stroma and the luminal compartment at all developmental stages...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27807724/rs15869-at-mirna-binding-site-in-brca2-is-associated-with-breast-cancer-susceptibility
#14
Jingjing Cao, Chenglin Luo, Rui Yan, Rui Peng, Kaijuan Wang, Peng Wang, Hua Ye, Chunhua Song
BRCA1 and BRCA2 mutations confer an increased lifetime risk of breast cancer; however, the associations of microRNA (miRNA) binding site single nucleotide polymorphisms (SNPs) in 3' untranslated region (3'-UTR) of BRCA1 and BRCA2 with breast cancer (BC) risk were rarely reported. In this case-control study (498 BC patients and 498 matched controls), three SNPs (rs8176318, rs12516 and rs15869) were selected in the 3'-UTR of BRCA1 and BRCA2 genes, which were within miRNA-binding seed regions and might have potential function to regulate the expression of BRCA1/BRCA2...
December 2016: Medical Oncology
https://www.readbyqxmd.com/read/27798604/lgr6-labels-a-rare-population-of-mammary-gland-progenitor-cells-that-are-able-to-originate-luminal-mammary-tumours
#15
Leander Blaas, Fabio Pucci, Hendrik A Messal, Agneta B Andersson, E Josue Ruiz, Marco Gerling, Iyadh Douagi, Bradley Spencer-Dene, Alexandra Musch, Richard Mitter, Leena Bhaw, Richard Stone, Dorothee Bornhorst, Abdul K Sesay, Jos Jonkers, Gordon Stamp, Ilaria Malanchi, Rune Toftgård, Axel Behrens
The mammary gland is composed of a complex cellular hierarchy with unusual postnatal plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells that give rise to breast cancer, are incompletely understood. Here we show that Lgr6 marks rare populations of cells in both basal and luminal mammary gland compartments in mice. Lineage tracing analysis showed that Lgr6(+) cells are unipotent progenitors, which expand clonally during puberty but diminish in adulthood. In pregnancy or following stimulation with ovarian hormones, adult Lgr6(+) cells regained proliferative potency and their progeny formed alveoli over repeated pregnancies...
October 31, 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27797258/anthropometric-and-reproductive-factors-among-newly-diagnosed-breast-cancer-patients-and-healthy-women-a-case-control-study
#16
Z Zunura'in, A R Ainaa Almardhiyah, S H Gan, Wan N Arifin, Kns Sirajudeen, Vmk Bhavaraju, Suzana Shahar, J M Hamid Jan
The objective of this case-control study was to determine anthropometric and reproductive factors associated with the development of breast cancer among women. Fifty-six newly diagnosed breast cancer patients were recruited from the Oncology Clinic, Universiti Sains Malaysia (USM), and 56 healthy female hospital employees were recruited as controls. Socio-demographic and reproductive data were obtained using a standard questionnaire. Anthropometric factors (body weight, height, body fat percentage, visceral fat and waist and hip circumference) were assessed...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27796958/purification-of-distinct-subsets-of-epithelial-cells-from-normal-human-breast-tissue
#17
Mona Shehata, John Stingl
The mammary epithelium is composed of a variety of specialized cell types that function in a coordinated fashion to produce and eject milk through multiple cycles of pregnancy. The ability to identify and purify these subsets of cells in order to interrogate their growth and differentiation capacities, as well as to characterize the molecular mechanisms that regulate their behavior, is essential in identifying the processes associated with breast cancer initiation and progression. This methods chapter outlines the step-by-step methods for dissociating human breast reduction specimens to a single cell suspension of viable cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27796946/overview-of-mammary-gland-development-a-comparison-of-mouse-and-human
#18
Sara McNally, Torsten Stein
The mouse mammary gland is widely used as a model for human breast cancer and has greatly added to our understanding of the molecular mechanisms involved in breast cancer development and progression. To fully appreciate the validity and limitations of the mouse model, it is essential to be aware of the similarities and also the differences that exist between the mouse mammary gland and the human breast. This introduction therefore describes the parallels and contrasts in mouse mammary gland and human breast morphogenesis from an early embryonic phase through to puberty, adulthood, pregnancy, parturition, and lactation, and finally the regressive stage of involution...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27793013/mammary-gland-stem-cells-and-their-application-in-breast-cancer
#19
REVIEW
Xing Yang, Hui Wang, Baowei Jiao
The mammary gland is an organ comprising two primary lineages, specifically the inner luminal and the outer myoepithelial cell layers. Mammary gland stem cells (MaSCs) are highly dynamic and self-renewing, and can give rise to these mammary gland lineages. The lineages are responsible for gland generation during puberty as well as expansion during pregnancy. In recent years, researchers have focused on understanding how MaSCs are regulated during mammary gland development and transformation of breast cancer...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27784743/human-chorionic-gonadotropin-does-not-correlate-with-risk-for-maternal-breast-cancer-results-from-the-finnish-maternity-cohort
#20
Renée T Fortner, Helena Schock, Rudolf Kaaks, Matti Lehtinen, Eero Pukkala, Hans-Åke Lakso, Minna Tanner, Raija Kallio, Heikki Joensuu, Jaana Korpela, Adetunji T Toriola, Goran Hallmans, Kjell Grankvist, Anne Zeleniuch-Jacquotte, Paolo Toniolo, Eva Lundin, Helja-Marja Surcel
Human chorionic gonadotropin (hCG) is necessary for the maintenance of early pregnancy and promotes normal breast cell differentiation. Administered hCG reduces risk of carcinogen-induced breast cancer in animal models, and higher circulating hCG concentrations were associated with significantly lower long-term risk of breast cancer in a prior nested case-control study. In this study, we investigated early pregnancy hCG concentrations and subsequent breast cancer risk. We conducted a nested case-control study with 1,191 cases and 2,257 controls (matched on age and date at blood collection) in the Finnish Maternity Cohort (FMC), a cohort with serum samples from 98% of pregnancies registered in Finland since 1983...
October 26, 2016: Cancer Research
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