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Intersectionality

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https://www.readbyqxmd.com/read/28426316/mechanisms-linking-hiv-related-stigma-adherence-to-treatment-and-health-outcomes-a-conceptual-framework
#1
Bulent Turan, Abigail M Hatcher, Sheri D Weiser, Mallory O Johnson, Whitney S Rice, Janet M Turan
We present a conceptual framework that highlights how unique dimensions of individual-level HIV-related stigma (perceived community stigma, experienced stigma, internalized stigma, and anticipated stigma) might differently affect the health of those living with HIV. HIV-related stigma is recognized as a barrier to both HIV prevention and engagement in HIV care, but little is known about the mechanisms through which stigma leads to worse health behaviors or outcomes. Our conceptual framework posits that, in the context of intersectional and structural stigmas, individual-level dimensions of HIV-related stigma operate through interpersonal factors, mental health, psychological resources, and biological stress pathways...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28425119/mean-intercept-anisotropy-analysis-of-porous-media-i-analytic-formulae-for-anisotropic-boolean-models
#2
Michael A Klatt, Gerd E Schröder-Turk, Klaus Mecke
PURPOSE: Structure-property relations, which relate the shape of the microstructure to physical properties such as transport or mechanical properties, need sensitive measures of structure. What are suitable fabric tensors to quantify the shape of anisotropic heterogeneous materials? The mean intercept length is among the most commonly used characteristics of anisotropy in porous media, for example, of trabecular bone in medical physics. METHODS: We analyze the orientation-biased Boolean model, a versatile stochastic model that represents microstructures as overlapping grains with an orientation bias towards a preferred direction...
April 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28424847/characterization-of-microtubule-buckling-in-living-cells
#3
Carla Pallavicini, Alejandro Monastra, Nicolás González Bardeci, Diana Wetzler, Valeria Levi, Luciana Bruno
Microtubules are filamentous biopolymers involved in essential biological processes. They form key structures in eukaryotic cells, and thus it is very important to determine the mechanisms involved in the formation and maintenance of the microtubule network. Microtubule bucklings are transient and localized events commonly observed in living cells and characterized by a fast bending and its posterior relaxation. Active forces provided by molecular motors have been indicated as responsible for most of these rapid deformations...
April 19, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28424651/racial-assumptions-color-the-mental-representation-of-social-class
#4
Ryan F Lei, Galen V Bodenhausen
We investigated the racial content of perceivers' mental images of different socioeconomic categories. We selected participants who were either high or low in prejudice toward the poor. These participants saw 400 pairs of visually noisy face images. Depending on condition, participants chose the face that looked like a poor person, a middle income person, or a rich person. We averaged the faces selected to create composite images of each social class. A second group of participants rated the stereotypical Blackness of these images...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28422999/zooming-in-from-spatially-extended-traveling-waves-to-localized-structures-the-case-of-the-sine-gordon-equation-in-1-3-dimensions
#5
Yair Zarmi
The Sine-Gordon equation in (1+3) dimensions has N-traveling front ("kink", "domain wall")- solutions for all N ≥ 1. A nonlinear functional of the solution, which vanishes on a single-front, maps multi-front solutions onto sets of infinitely long, but laterally bounded, rods, which move in space. Each rod is localized in the vicinity of the intersection of two Sine-Gordon fronts. The rod systems are solutions of the linear wave equation, driven by a term that is constructed out of Sine-Gordon fronts. An additional linear operation maps multi-rod systems onto sets of blobs...
2017: PloS One
https://www.readbyqxmd.com/read/28422783/lessons-learned-from-humoral-responses-of-hiv-patients
#6
Laura E McCoy, Áine McKnight
PURPOSE OF REVIEW: Since 2009 many broadly neutralizing antibodies against HIV have been identified, yet there is still no vaccine capable of inducing such antibodies in humans. This review considers the early observations of HIV sera neutralization in light of more recent studies and highlights areas for future research. RECENT FINDINGS: Large clinical cohort studies using standardized neutralization assays and pseudoviruses derived from primary isolates have shown that 10-30% of HIV infections result in some level of serum neutralization breadth...
May 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28421160/the-unfolded-protein-response-at-the-intersection-between-endoplasmic-reticulum-function-and-mitochondrial-bioenergetics
#7
REVIEW
Amado Carreras-Sureda, Philippe Pihán, Claudio Hetz
Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This functional integration is exerted through discrete interorganelle structures known as mitochondria-associated membranes (MAMs). At these domains, ER/mitochondria physically associate to dynamically adjust metabolic demands and the response to stress stimuli. Here, we provide a focused overview of how the ER shapes the function of the mitochondria, giving a special emphasis to the significance of local signaling of the unfolded protein response at MAMs...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28420876/examining-gray-matter-structure-associated-with-academic-performance-in-a-large-sample-of-chinese-high-school-students
#8
Song Wang, Ming Zhou, Taolin Chen, Xun Yang, Guangxiang Chen, Meiyun Wang, Qiyong Gong
Achievement in school is crucial for students to be able to pursue successful careers and lead happy lives in the future. Although many psychological attributes have been found to be associated with academic performance, the neural substrates of academic performance remain largely unknown. Here, we investigated the relationship between brain structure and academic performance in a large sample of high school students via structural magnetic resonance imaging (S-MRI) using voxel-based morphometry (VBM) approach...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420671/ptk7-localization-and-protein-stability-is-affected-by-canonical-wnt-ligands
#9
Hanna Berger, Marlen Breuer, Hanna Peradziryi, Martina Podleschny, Ralf Jacob, Annette Borchers
PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor with important roles in embryonic development and disease. Originally identified as a gene upregulated in colon cancer it was later shown to regulate planar cell polarity (PCP) and directional cell movement. PTK7 is a Wnt co-receptor, however its role in Wnt signaling remains controversial. Here, we find evidence that place PTK7 at the intersection of canonical and non-canonical Wnt signaling pathways. In presence of canonical Wnt ligands PTK7 is subject to caveolin-mediated endocytosis, while it is unaffected by non-canonical Wnt ligands...
April 18, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28420412/intersect-then-combine-approach-improving-the-performance-of-somatic-variant-calling-in-whole-exome-sequencing-data-using-multiple-aligners-and-callers
#10
Maurizio Callari, Stephen-John Sammut, Leticia De Mattos-Arruda, Alejandra Bruna, Oscar M Rueda, Suet-Feung Chin, Carlos Caldas
Bioinformatic analysis of genomic sequencing data to identify somatic mutations in cancer samples is far from achieving the required robustness and standardisation. In this study we generated a whole exome sequencing benchmark dataset using the platinum genome sample NA12878 and developed an intersect-then-combine (ITC) approach to increase the accuracy in calling single nucleotide variants (SNVs) and indels in tumour-normal pairs. We evaluated the effect of alignment, base quality recalibration, mutation caller and filtering on sensitivity and false positive rate...
April 18, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28420179/systematic-understanding-of-the-mechanism-of-salvianolic-acid-a-via-computational-target-fishing
#11
Shao-Jun Chen, Ming-Chao Cui
Salvianolic acid A (SAA) is one of the most abundant water-soluble and potent anti-oxidative compounds isolated from Danshen, a traditional Chinese medicine. A systematic overview of its mechanism of action is yet to be performed. In the present study, the druggability of SAA was measured using the TCMSP server, and potential targets of SAA were identified by PharmMapper and DRAR-CPI. Intersecting targets were then assessed by GeneMANIA and GO pathway analysis, and drug-target-pathway networks were constructed to give a visual view...
April 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28419593/protein-sumoylation-and-phosphorylation-intersect-in-arabidopsis-signaling
#12
Ella Nukarinen, Konstantin Tomanov, Ionida Ziba, Wolfram Weckwerth, Andreas Bachmair
Conjugation of the small ubiquitin-related modifier SUMO to protein substrates impacts on stress responses and on development. We analyzed the proteome and phosphoproteome of mutants in this pathway. Mutants chosen had defects in SUMO ligase SIZ1, which catalyzes attachment of single SUMO moieties onto substrates, and in ligases PIAL1 and 2, which are known to form SUMO chains. 2657 proteins and 550 phosphopeptides were identified and quantified. Approximately 40% of the proteins and 20% of the phosphopeptides showed abundance differences in at least one of the analyzed genotypes, demonstrating the influence of SUMO conjugation on protein abundance and phosphorylation...
April 17, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28419546/connexin43-and-runx2-interact-to-affect-cortical-bone-geometry-skeletal-development-and-osteoblast-and-osteoclast-function
#13
Atum M Buo, Ryan E Tomlinson, Eric R Eidelman, Max Chason, Joseph P Stains
The coupling of osteoblasts and osteocytes by connexin43 (Cx43) gap junctions permits the sharing of second messengers that coordinate bone cell function and cortical bone acquisition. However, details of how Cx43 converts shared second messengers into signals that converge onto essential osteogenic processes are incomplete. Here, we use in vitro and in vivo methods to show that Cx43 and Runx2 functionally interact to regulate osteoblast gene expression and proliferation, ultimately affecting cortical bone properties...
April 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28419476/cortactin-a-lyn-substrate-is-a-checkpoint-molecule-at-the-intersection-of-bcr-and-cxcr4-signalling-pathway-in-chronic-lymphocytic-leukaemia-cells
#14
Veronica Martini, Cristina Gattazzo, Federica Frezzato, Valentina Trimarco, Marco Pizzi, Giorgia Chiodin, Filippo Severin, Edoardo Scomazzon, Vincenza Guzzardo, Deborah Saraggi, Flavia Raggi, Leonardo Martinello, Monica Facco, Andrea Visentin, Francesco Piazza, Anna Maria Brunati, Gianpietro Semenzato, Livio Trentin
Cortactin (CTTN) is a substrate of the Src kinase Lyn that is known to play an actin cytoskeletal regulatory role involved in cell migration and cancer progression following its phosphorylation at Y421. We recently demonstrated that Cortactin is overexpressed in patients with chronic lymphocytic leukaemia (CLL). This work was aimed at defining the functional role of Cortactin in these patients. We found that Cortactin is variably expressed in CLL patients both in the peripheral blood and lymph nodes and that its expression correlates with the release of matrix metalloproteinase 9 (MMP-9) and the motility of neoplastic cells...
April 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28418817/virtual-mapping-of-the-frontal-recess-guiding-safe-and-efficient-frontal-sinus-surgery
#15
Neil S Patel, Amy C Dearking, Erin K O'Brien, John F Pallanch
Objective To define relationships between the frontal sinus opening, ostia of other frontal recess cells, and endoscopic landmarks and to develop a clinically useful framework to guide frontal sinus surgery. Study Design Retrospective review. Setting Tertiary care academic referral center. Methods Adult patients with computed tomography (CT) without sinonasal pathology were included. Virtual endoscopy (using OsiriX) and corresponding CT reconstructions were used to identify all visible ostia in the frontal recess and characterize their positions in spaces between the uncinate/agger nasi (U), bulla ethmoidalis (EB), and middle turbinate (MT)...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28418680/dual-functional-tamm-dancoff-approximation-a-convenient-density-functional-method-that-correctly-describes-s1-s0-conical-intersections
#16
Yinan Shu, Kelsey Anne Parker, Donald G Truhlar
Time-dependent Kohn-Sham density functional theory has been used successfully to compute vertical excitation energies, especially for large molecular systems. However, the lack of double excitation character in the excited amplitudes produced by linear response in the adiabatic approximation holds it back from broader applications in photochemistry; for example, it shows (3N-7)-dimensional conical intersection seams (where N is the number of atoms) between ground and excited states, although the correct dimensionality is 3N-8...
April 18, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28418453/association-of-increasing-nasal-tip-projection-with-lip-position-in-primary-rhinoplasty
#17
Eric W Cerrati, Steven H Dayan
Importance: The effects of rhinoplasty maneuvers on adjacent facial features are an important component in preoperative planning and patient counseling. Tip projection modifications are commonly performed in both cosmetic and reconstructive rhinoplasty. Objective: To evaluate the subsequent change in lip projection that results from increasing nasal tip projection. Design, Setting, and Participants: In this case series, 20 patients underwent primary rhinoplasty with the objective of increasing tip projection during the period from October 1, 2014, to September 25, 2015...
April 13, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28418279/intersectional-stigma-among-midlife-and-older-black-women-living-with-hiv
#18
Thurka Sangaramoorthy, Amelia Jamison, Typhanye Dyer
HIV-related stigma is a barrier to the prevention and treatment of HIV. For midlife and older Black women, the nature and intensity of HIV-related stigma may be compounded by their multiple marginalised social status based on gender, race, and age. We examined the perceptions and experiences of HIV-related stigma among midlife and older Black women living in Prince George's County, Maryland, USA. Between 2014 and 2015, we conducted semi-structured interviews with a sample of 35 midlife and older Black women living with HIV...
April 18, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28417441/relationships-between-essential-manganese-biology-and-manganese-toxicity-in-neurological-disease
#19
REVIEW
Anna C Pfalzer, Aaron B Bowman
PURPOSE OF REVIEW: Manganese (Mn) is critical for neurodevelopment but also has been implicated in the pathophysiology of several neurological diseases. We discuss how Mn requirements intersect with Mn biology and toxicity, and how these requirements may be altered in neurological disease. Furthermore, we discuss the emerging evidence that the level of Mn associated with optimal overall efficiency for Mn biology does not necessarily coincide with optimal cognitive outcomes. RECENT FINDINGS: Studies have linked Mn exposures with urea cycle metabolism and autophagy, with evidence that exposures typically neurotoxic may be able to correct deficiencies in these processes at least short term...
April 17, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28417310/telemedicine-and-palliative-care-an-increasing-role-in-supportive-oncology
#20
REVIEW
Brooke Worster, Kristine Swartz
With the emergence of telemedicine as a routine form of care in various venues, the opportunities to use technology to care for the most vulnerable, most ill cancer patients are extremely appealing. Increasingly, evidence supports early integration of palliative care with standard oncologic care, supported by recent NCCN guidelines to increase and improve access to palliative care. This review looks at the use of telemedicine to expand access to palliative care as well as provide better care for patients and families where travel is difficult, if not impossible...
June 2017: Current Oncology Reports
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