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https://www.readbyqxmd.com/read/28727728/an-integrative-genomics-approach-identifies-novel-pathways-that-influence-candidaemia-susceptibility
#1
Vasiliki Matzaraki, Mark S Gresnigt, Martin Jaeger, Isis Ricaño-Ponce, Melissa D Johnson, Marije Oosting, Lude Franke, Sebo Withoff, John R Perfect, Leo A B Joosten, Bart Jan Kullberg, Frank L van de Veerdonk, Iris Jonkers, Yang Li, Cisca Wijmenga, Mihai G Netea, Vinod Kumar
Candidaemia is a bloodstream infection caused by Candida species that primarily affects specific groups of at-risk patients. Because only small candidaemia patient cohorts are available, classical genome wide association cannot be used to identify Candida susceptibility genes. Therefore, we have applied an integrative genomics approach to identify novel susceptibility genes and pathways for candidaemia. Candida-induced transcriptome changes in human primary leukocytes were assessed by RNA sequencing. Genetic susceptibility to candidaemia was assessed using the Illumina immunochip platform for genotyping of a cohort of 217 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28727530/homicide-rates-of-transgender-individuals-in-the-united-states-2010-2014
#2
Alexis Dinno
OBJECTIVES: To estimate homicide rates of transgender US residents and relative risks (RRs) of homicide with respect to cisgender comparators intersected with age, gender, and race/ethnicity. METHODS: I estimated homicide rates for transgender residents and transfeminine, Black, Latin@, and young (aged 15-34 years) subpopulations during the period 2010 to 2014 using Transgender Day of Remembrance and National Coalition of Anti-Violence Programs transgender homicide data...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28726832/three-dimensional-magnetization-structures-revealed-with-x-ray-vector-nanotomography
#3
Claire Donnelly, Manuel Guizar-Sicairos, Valerio Scagnoli, Sebastian Gliga, Mirko Holler, Jörg Raabe, Laura J Heyderman
In soft ferromagnetic materials, the smoothly varying magnetization leads to the formation of fundamental patterns such as domains, vortices and domain walls. These have been studied extensively in thin films of thicknesses up to around 200 nanometres, in which the magnetization is accessible with current transmission imaging methods that make use of electrons or soft X-rays. In thicker samples, however, in which the magnetization structure varies throughout the thickness and is intrinsically three dimensional, determining the complex magnetic structure directly still represents a challenge...
July 19, 2017: Nature
https://www.readbyqxmd.com/read/28726738/scheduling-for-emergency-tasks-in-industrial-wireless-sensor-networks
#4
Changqing Xia, Xi Jin, Linghe Kong, Peng Zeng
Wireless sensor networks (WSNs) are widely applied in industrial manufacturing systems. By means of centralized control, the real-time requirement and reliability can be provided by WSNs in industrial production. Furthermore, many approaches reserve resources for situations in which the controller cannot perform centralized resource allocation. The controller assigns these resources as it becomes aware of when and where accidents have occurred. However, the reserved resources are limited, and such incidents are low-probability events...
July 20, 2017: Sensors
https://www.readbyqxmd.com/read/28725508/the-anatomy-of-the-dorsal-capsulo-scapholunate-septum-a-cadaveric-study
#5
Marina Tommasini Carrara de Sambuy, Tanya Michelle Burgess, Adeline Cambon-Binder, Christophe L Mathoulin
Background  Tears of the dorsal radiocarpal capsule at the level of the scapholunate interosseous ligament (SLIL) have recently been described in association with predynamic scapholunate instability. Purpose  The aim of this anatomical study of the dorsal capsulo-scapholunate septum (DCSS) was to examine the connection of the dorsal capsule on the SLIL and dorsal intercarpal ligament (DICL). Methods  Fourteen fresh frozen wrists from seven adult cadavers were dissected through a dorsal approach. Any dorsal attachment of the DICL on the dorsal surface of the SLIL, that is, the DCSS, was identified and measured (height and width)...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28725385/do-movement-behaviors-identify-reproductive-habitat-sampling-for-wild-turkeys
#6
Mason D Conley, Nathan A Yeldell, Michael J Chamberlain, Bret A Collier
Selection of habitats has regularly been suggested to influence species demography at both local and broad scales. The expectation is that selection behaviors have positive benefits via greater fitness or increased survival. The current paradigm of habitat selection theory suggests a hierarchical process, where an individual first selects where they choose to live (e.g., range) and then searches and selects locations within this range meeting life history needs. Using high-frequency GPS data collected from reproductively active Rio Grande (n = 21) and Eastern (n = 23) wild turkeys, we evaluated a long-standing theory for ground-nesting galliformes, in that movements during the prenesting period are behaviorally focused on sampling available habitats to optimize the selection of nesting sites...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28725281/introduction-testing-and-refining-marc-lewis-s-critique-of-the-brain-disease-model-of-addiction
#7
Anke Snoek, Steve Matthews
In this introduction we set out some salient themes that will help structure understanding of a complex set of intersecting issues discussed in this special issue on the work of Marc Lewis: (1) conceptual foundations of the disease model, (2) tolerating the disease model given socio-political environments, and (3) A third wave: refining conceptualization of addiction in the light of Lewis's model.
2017: Neuroethics
https://www.readbyqxmd.com/read/28724735/dual-function-of-the-pectoral-girdle-for-feeding-and-locomotion-in-white-spotted-bamboo-sharks
#8
Ariel L Camp, Bradley Scott, Elizabeth L Brainerd, Cheryl D Wilga
Positioned at the intersection of the head, body and forelimb, the pectoral girdle has the potential to function in both feeding and locomotor behaviours-although the latter has been studied far more. In ray-finned fishes, the pectoral girdle attaches directly to the skull and is retracted during suction feeding, enabling the ventral body muscles to power rapid mouth expansion. However, in sharks, the pectoral girdle is displaced caudally and entirely separate from the skull (as in tetrapods), raising the question of whether it is mobile during suction feeding and contributing to suction expansion...
July 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28724614/nuclear-mtor-acts-as-a-transcriptional-integrator-of-the-androgen-signaling-pathway-in-prostate-cancer
#9
Étienne Audet-Walsh, Catherine R Dufour, Tracey Yee, Fatima Z Zouanat, Ming Yan, Georges Kalloghlian, Mathieu Vernier, Maxime Caron, Guillaume Bourque, Eleonora Scarlata, Lucie Hamel, Fadi Brimo, Armen G Aprikian, Jacques Lapointe, Simone Chevalier, Vincent Giguère
Androgen receptor (AR) signaling reprograms cellular metabolism to support prostate cancer (PCa) growth and survival. Another key regulator of cellular metabolism is mTOR, a kinase found in diverse protein complexes and cellular localizations, including the nucleus. However, whether nuclear mTOR plays a role in PCa progression and participates in direct transcriptional cross-talk with the AR is unknown. Here, via the intersection of gene expression, genomic, and metabolic studies, we reveal the existence of a nuclear mTOR-AR transcriptional axis integral to the metabolic rewiring of PCa cells...
July 19, 2017: Genes & Development
https://www.readbyqxmd.com/read/28724397/partial-uniparental-isodisomy-of-chromosome-16-unmasks-a-deleterious-biallelic-mutation-in-ift140-that-causes-mainzer-saldino-syndrome
#10
Benjamin M Helm, Jason R Willer, Azita Sadeghpour, Christelle Golzio, Eric Crouch, Samantha Schrier Vergano, Nicholas Katsanis, Erica E Davis
BACKGROUND: The ciliopathies represent an umbrella group of >50 clinical entities that share both clinical features and molecular etiology underscored by structural and functional defects of the primary cilium. Despite the advances in gene discovery, this group of entities continues to pose a diagnostic challenge, in part due to significant genetic and phenotypic heterogeneity and variability. We consulted a pediatric case from asymptomatic, non-consanguineous parents who presented as a suspected ciliopathy due to a constellation of retinal, renal, and skeletal findings...
July 19, 2017: Human Genomics
https://www.readbyqxmd.com/read/28722807/-the-difference-being-a-woman-made-untold-lives-in-personal-and-intellectual-context
#11
Alexandra Rutherford, Katharine Milar
To mark the 30th anniversary of the publication of Scarborough and Furumoto's classic work Untold Lives, and to honor the intellectual legacy of Elizabeth Scarborough (1935-2015), we introduce this special issue devoted to the histories of women, gender, and feminism in psychology. We provide a short biographical sketch of Elizabeth, highlighting her own marriage-career dilemma, then contextualize the publication of Untold Lives within the historiography on women in psychology at that time. We conclude by discussing intersectionality as an analytic framework for the history of psychology as a way to extend and enrich this historiography...
July 2017: Journal of the History of the Behavioral Sciences
https://www.readbyqxmd.com/read/28722331/hepatitis-c-virus-and-proprotein-convertase-subtilisin-kexin-type-9-a-detrimental-interaction-to-increase-viral-infectivity-and-disrupt-lipid-metabolism
#12
REVIEW
Matteo Pirro, Vanessa Bianconi, Daniela Francisci, Elisabetta Schiaroli, Francesco Bagaglia, Amirhossein Sahebkar, Franco Baldelli
From viral binding to the hepatocyte surface to extracellular virion release, the replication cycle of the hepatitis C virus (HCV) intersects at various levels with lipid metabolism; this leads to a derangement of the lipid profile and to increased viral infectivity. Accumulating evidence supports the crucial regulatory role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipoprotein metabolism. Notably, a complex interaction between HCV and PCSK9 has been documented. Indeed, either increased or reduced circulating PCSK9 levels have been observed in HCV patients; this discrepancy might be related to several confounders, including HCV genotype, human immunodeficiency virus (HIV) coinfection and the ambiguous HCV-mediated influence on PCSK9 transcription factors...
July 18, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28721902/permeability-of-brain-tumor-vessels-induced-by-uniform-or-spatially-microfractionated-synchrotron-radiation-therapies
#13
Audrey Bouchet, Marine Potez, Nicolas Coquery, Claire Rome, Benjamin Lemasson, Elke Bräuer-Krisch, Chantal Rémy, Jean Laissue, Emmanuel L Barbier, Valentin Djonov, Raphael Serduc
PURPOSE: To compare the blood-brain barrier permeability changes induced by synchrotron microbeam radiation therapy (MRT, which relies on spatial fractionation of the incident x-ray beam into parallel micron-wide beams) with changes induced by a spatially uniform synchrotron x-ray radiation therapy. METHODS AND MATERIALS: Male rats bearing malignant intracranial F98 gliomas were randomized into 3 groups: untreated, exposed to MRT (peak and valley dose: 241 and 10...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721501/examining-transgender-health-through-the-international-classification-of-functioning-disability-and-health-s-icf-contextual-factors
#14
REVIEW
Melissa Jacob, Steven R Cox
PURPOSE: For many transgender individuals, medical intervention is necessary to live as their desired gender. However, little is known about Contextual Factors (i.e., Environmental and Personal) that may act as facilitators and barriers in the health of transgender individuals. Therefore, this paper sought to examine Contextual Factors of the World Health Organization's International Classification of Functioning, Disability, and Health that may facilitate or negatively impact the physical, psychological, and social functioning of transgender individuals...
July 18, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28720818/structural-and-rheological-properties-conferring-fertilization-competence-to-xenopus-egg-coating-envelope
#15
Mayu Hanaue, Naofumi Miwa
The extracellular egg-coating envelope that comprises a meshwork of filaments polymerized by glycoproteins plays a pivotal role in species-selective sperm recognition and subsequent fertilization; however, the structural and rheological properties conferring fertilization competence to the egg-coating envelope remain poorly unveiled. Here we show several nanoscale-structural and viscoelastic properties of the egg-coat using the transmission electron microscopy and the quartz crystal microbalance experiments, following clamp of the egg-coat at either fertilization-competent or -incompetent statuses by short-term pretreatment with synthetic peptides...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720637/intersection-syndrome-the-subtle-squeak-of-an-overused-wrist
#16
Thomas M Skinner
Patient histories that include wrist pain can be pivotal in the distinction between intersection syndrome (IS) and the more common de Quervain's tenosynovitis (DQT). Presented here is a 26-year-old pregnant woman with a history of rowing who developed left radial/dorsal wrist pain and a rubbing/squeaking sensation. Nine months of conservative DQT therapy and a landmark-guided corticosteroid injection failed to relieve her symptoms. An in-clinic ultrasound showed tenosynovitis at the intersection of the first and second compartments, confirming a diagnosis of IS...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28720448/the-feminization-of-hpv-how-science-politics-economics-and-gender-norms-shaped-u-s-hpv-vaccine-implementation
#17
Ellen M Daley, Cheryl A Vamos, Erika L Thompson, Gregory D Zimet, Zeev Rosberger, Laura Merrell, Nolan S Kline
Human papillomavirus (HPV) can cause a number of anogenital cancers (i.e., cervical, penile, anal, vaginal, vulvar) and genital warts. A decade ago, the HPV vaccine was approved, and has been shown to be a public health achievement that can reduce the morbidity and mortality for HPV-associated diseases. Yet, the mistaken over-identification of HPV as a female-specific disease has resulted in the feminization of HPV and HPV vaccines. In this critical review, we trace the evolution of the intersection of science, politics, economics and gender norms during the original HPV vaccine approval, marketing era, and implementation...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28718634/porous-uranyl-borophosphates-with-unique-three-dimensional-open-framework-structures
#18
Yucheng Hao, Gabriel L Murphy, Dirk Bosbach, Giuseppe Modolo, Thomas E Albrecht-Schmitt, Evgeny V Alekseev
Two novel alkali-metal uranyl borophosphates have been prepared and characterized for the first time, namely, K5(UO2)2[B2P3O12(OH)]2(OH)(H2O)2 and K2(UO2)12[B(H2PO4)4](PO4)8(OH)(H2O)6 denoted as KUPB1 and KUPB2, respectively. KUPB1 was obtained hydrothermally at 220 °C and crystallizes in a monoclinic structure in the chiral space group P21. The unit cell parameters of KUPB1 are a = 6.7623(2) Å, b = 19.5584(7) Å, c = 11.0110(4) Å, α = γ = 90°, β = 95.579(3)°, and V = 1449.42(8) Å(3). It features a unique three-dimensional (3D) open-framework structure, composed of two corner-sharing linked one-dimensional (1D) anionic borophosphates (BP), [B2P3O13](5-), along the a axis and uranyl phosphate (UP), [(UO2)(PO4)3](7-), chains along the c axis, further bridged by PO4 tetrahedra...
July 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28718505/immunogenomic-approaches-to-understand-the-function-of-immune-disease-variants
#19
REVIEW
Dafni Anna Glinos, Blagoje Soskic, Gosia Trynka
Mapping hundreds of genetic variants through genome wide association studies provided an opportunity to gain insights into the pathobiology of immune mediated diseases. However, since most of the disease variants fall outside the gene coding sequences, thereby implicating gene expression regulation as the causal mechanism, the functional interpretation of the exact role of the associated variants remains to be determined. Despite these challenges, integration of disease associated variants with large scale genomic maps of cell type specific gene regulation both at chromatin and transcript levels deliver examples of functionally prioritised causal variants and genes...
July 17, 2017: Immunology
https://www.readbyqxmd.com/read/28715909/ribosomal-stalling-during-translation-providing-substrates-for-ribosome-associated-protein-quality-control
#20
Claudio A P Joazeiro
Cells of all organisms survey problems during translation elongation, which may happen as a consequence of mRNA aberrations, inefficient decoding, or other sources. In eukaryotes, ribosome-associated quality control (RQC) senses elongation-stalled ribosomes and promotes dissociation of ribosomal subunits. This so-called ribosomal rescue releases the mRNA for degradation and allows 40S subunits to be recycled for new rounds of translation. However, the nascent polypeptide chains remain linked to tRNA and associated with the rescued 60S subunits...
July 17, 2017: Annual Review of Cell and Developmental Biology
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