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https://www.readbyqxmd.com/read/28636880/behavioral-evidence-of-oxidative-stress-by-hematophagy-in-the-ocellar-system-of-rhodnius-prolixus-st%C3%A3-l-1859-red-eyed-mutants
#1
Carlos Alberto Vija Suarez, Mario Iván Ortiz, Jorge Molina
The photonegative response to light stimulation in Rhodnius prolixus (Reduviidae, Triatominae) is modulated by compound eyes and ocelli. Screening pigments in the visual system have been shown to protect the cellular structures from the oxidative stress damage produced by blood ingestion and light stimulation. Red-eyed mutants of Rhodnius prolixus lack screening pigments in their compound eyes and ocelli and are exposed to more oxidative stress. Experiments with Rhodnius prolixus and Triatoma infestans red-eyed mutants reared from the first nymphal stage show damage in the retinas of the compound eyes and a decrease in photonegative responses due to light stimulation...
June 18, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28636768/driving-aggression-and-anxiety-intersections-assessment-and-interventions
#2
Heidi M Zinzow, Stephanie M Jeffirs
OBJECTIVE: Driving aggression and anxiety are significant contributors to risky driving and motor vehicle crashes (MVCs), which are leading causes of U.S. morbidity and mortality. Even though aggression and anxiety can be conceptualized as related features of the fight-or-flight response, literature on these topics has not been integrated. Driving aggression and anxiety are also transdiagnostic constructs that span multiple psychiatric disorders. Assessment and treatment of these complex problems must be understood to reduce the public health burden of MVCs...
June 21, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28636489/evaluation-of-countermeasures-for-red-light-running-by-traffic-simulator-based-surrogate-safety-measures
#3
Changju Lee, Jaehyun Jason So, Jiaqi Ma
OBJECTIVE: The conflicts among motorists entering a signalized intersection with the red light indication have become a national safety issue. Because of its sensitivity, efforts have been made to investigate the possible causes and effectiveness of countermeasures by the comparison sites and/or before-and-after studies. Nevertheless, these approaches are ineffective when comparison sites cannot be found, or crash data sets are not readily available or not reliable for statistical analysis...
June 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28633564/energy-harvesting-from-the-animal-human-body-for-self-powered-electronics
#4
Canan Dagdeviren, Zhou Li, Zhong Lin Wang
Living subjects (i.e., humans and animals) have abundant sources of energy in chemical, thermal, and mechanical forms. The use of these energies presents a viable way to overcome the battery capacity limitation that constrains the long-term operation of wearable/implantable devices. The intersection of novel materials and fabrication techniques offers boundless possibilities for the benefit of human health and well-being via various types of energy harvesters. This review summarizes the existing approaches that have been demonstrated to harvest energy from the bodies of living subjects for self-powered electronics...
June 21, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28632177/the-intersection-of-ngf-trka-signaling-and-amyloid-precursor-protein-processing-in-alzheimer-s-disease-neuropathology
#5
REVIEW
Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano
Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A (TrkA) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (BFCN) associated with the progressive cognitive decline in Alzheimer's disease (AD). The aim of this review is to describe our progress in elucidating the molecular mechanisms underlying the dynamic interplay between NGF/TrkA signaling and amyloid precursor protein (APP) metabolism within the context of AD neuropathology...
June 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28631898/mass-spectrometry-based-protein-analytics-to-unravel-the-tissue-pathophysiology-in-duchenne-muscular-dystrophy
#6
Stephanie J Carr, René P Zahedi, Hanns Lochmüller, Andreas Roos
Duchenne muscular dystrophy (DMD) is a genetic muscle wasting condition with limited treatment options available and is caused by the lack of Dystrophin. However, pathophysiology of different tissues is variable showing different histological and molecular signatures. Recently, a number of studies have employed gel-free proteomic approaches to unveil the molecular pathophysiology in terms of tissue-specific proteome changes in dystrophin-deficiency. We analysed studies in models of dystrophin-deficiency and patients both from the published literature...
June 20, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28630971/2-thiouracil-intersystem-crossing-photodynamics-studied-by-wavelength-dependent-photoelectron-and-transient-absorption-spectroscopies
#7
José A Sánchez-Rodríguez, Abed Mohamadzade, Sebastian Mai, Brennan Ashwood, Marvin Pollum, Philipp Marquetand, Leticia González, Carlos E Crespo-Hernández, Susanne Ullrich
Single-atom substitution within a natural nucleobase-such as replacing oxygen by sulfur in uracil-can result in drastic changes in the relaxation dynamics after UV excitation. While the photodynamics of natural nucleobases like uracil are dominated by pathways along singlet excited states, the photodynamics of thiobases like 2-thiouracil populate the triplet manifold with near unity quantum yield. In the present study, a synergistic approach based on time-resolved photoelectron spectroscopy (TRPES), time-resolved absorption spectroscopy (TRAS), and ab initio computations has been particularly successful at unraveling the underlying photophysical principles and describing the dissimilarities between the natural and substituted nucleobases...
June 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28629936/logit-log-evaluation-of-planar-yeast-estrogen-screens
#8
Dinah Schick, Wolfgang Schwack
Receptor assays like the yeast estrogen screen (YES) performed in microtiter plates normally provide dose-response curves with a sigmoidal shape in semi-log plots. Such sigmoidal plots can be linearized by the logit function resulting in logit-log plots, as mainly known for the evaluation of enzyme-linked immunosorbent assays and radioimmunoassays. Since the planar yeast estrogen screen (pYES) represents the transfer of the receptor assay YES to high-performance thin-layer chromatography (HPTLC), it was assumed to obtain sigmoidal shaped dose-response curves from the measured signals, which subsequently could be used to generate logit-log plots...
June 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28629193/telomere-biology-insights-into-an-intriguing-phenomenon
#9
REVIEW
Shriram Venkatesan, Aik Kia Khaw, Manoor Prakash Hande
Bacteria and viruses possess circular DNA, whereas eukaryotes with typically very large DNA molecules have had to evolve into linear chromosomes to circumvent the problem of supercoiling circular DNA of that size. Consequently, such organisms possess telomeres to cap chromosome ends. Telomeres are essentially tandem repeats of any DNA sequence that are present at the ends of chromosomes. Their biology has been an enigmatic one, involving various molecules interacting dynamically in an evolutionarily well-trimmed fashion...
June 19, 2017: Cells
https://www.readbyqxmd.com/read/28628952/seeking-comfort-in-an-uncomfortable-chair
#10
Elena Molinari
The author explores the concept of comfort in relation to the setting. The concept of comfort, an unusual word in the psychoanalytic lexicon, describes the intuitive and complex experience of patient and analyst being together in the analytic office. The couch and the chair are not the only tools of the setting, but they are potential instruments with which to study the therapeutic process, both in high-frequency therapy and in lower-frequency treatments. To describe the transformations that an alternative experience of comfort can promote, the author looks at the intersection of this concept with the body-mind relationship and with the Bionian concept of binocular vision...
April 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28625413/invisible-people-with-invisible-pain-a-commentary-on-even-my-sister-says-i-m-acting-like-a-crazy-to-get-a-check-race-gender-and-moral-boundary-work-in-women-s-claims-of-disabling-chronic-pain
#11
Joanna Kempner
This commentary to Pryma's (2017) article on women with fibromyalgia argues that intersectional approaches to health research can reveal not only how racialized institutions shape illness experience and medical care, but also how these institutions make some individuals visible, while rendering others invisible. Perhaps by adopting an intersectional approach to understanding health, we can start to unpack the multiple jeopardies faced by people of color in pain.
June 10, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28623749/evaluating-the-safety-in-numbers-effect-for-pedestrians-at-urban-intersections
#12
Brendan Murphy, David M Levinson, Andrew Owen
Assessment of collision risk between pedestrians and automobiles offers a powerful and informative tool in urban planning applications, and can be leveraged to inform proper placement of improvements and treatment projects to improve pedestrian safety. Such assessment can be performed using existing datasets of crashes, pedestrian counts, and automobile traffic flows to identify intersections or corridors characterized by elevated collision risks to pedestrians. The Safety In Numbers phenomenon, which refers to the observable effect that pedestrian safety is positively correlated with increased pedestrian traffic in a given area (i...
June 14, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28623542/identification-of-differentially-expressed-mirnas-associated-with-chronic-kidney-disease-mineral-bone-disorder
#13
Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim
The purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney disease (CKD) to predict putative microRNA (miRNA) in CKD-mineral bone disorder (CKD-MBD) and confirm the changes in these genes and miRNA expression under uremic conditions by using a cell culture system. PubMed searches using MeSH terms and keywords related to CKD, uremia, and mRNA arrays were conducted. Through a computational analysis, a meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAs associated with CKD-MBD was determined...
June 14, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28623440/the-impact-of-baccalaureate-medical-humanities-on-subsequent-medical-training-and-practice-a-physician-educator-s-perspective
#14
Lauren Barron
This reflective essay is an attempt to organize trends in feedback I have observed during ten years of coursework, conversations, and correspondence with former students associated with the Medical Humanities Program at Baylor University. Over the years, recurrent themes arise when speaking with alumni about whether and how their medical humanities experience intersects with their current training. I have identified five particular domains in which baccalaureate medical humanities training affects students' subsequent healthcare professions training and practice: context and complementarity, clinical relevance, reflective practice, professional preparedness and vocational calling...
June 17, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28622057/sending-messages-how-faculty-influence-professionalism-teaching-and-learning
#15
Lorraine Hawick, Jennifer Cleland, Simon Kitto
BACKGROUND: Ambiguity in understanding what "professionalism" means, and uncertainty in how best to teach it, remains. This study aimed to explore experiences of senior faculty in their endeavor to develop and include professionalism within a curriculum reform (CR), and illuminate challenges encountered. METHODS: Using a qualitative case study approach, data were collected from interviews with faculty who were involved in a major CR, plus archived document analysis to provide context, and aid triangulation...
June 16, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28620341/the-intersection-between-ocular-and-manual-motor-control-eye-hand-coordination-in-acquired-brain-injury
#16
REVIEW
John-Ross Rizzo, Maryam Hosseini, Eric A Wong, Wayne E Mackey, James K Fung, Edmond Ahdoot, Janet C Rucker, Preeti Raghavan, Michael S Landy, Todd E Hudson
Acute and chronic disease processes that lead to cerebral injury can often be clinically challenging diagnostically, prognostically, and therapeutically. Neurodegenerative processes are one such elusive diagnostic group, given their often diffuse and indolent nature, creating difficulties in pinpointing specific structural abnormalities that relate to functional limitations. A number of studies in recent years have focused on eye-hand coordination (EHC) in the setting of acquired brain injury (ABI), highlighting the important set of interconnected functions of the eye and hand and their relevance in neurological conditions...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28619530/neural-networks-underlying-language-and-social-cognition-during-self-other-processing-in-autism-spectrum-disorders
#17
Rajesh K Kana, Emma B Sartin, Carl Stevens, Hrishikesh D Deshpande, Christopher Klein, Mark R Klinger, Laura Grofer Klinger
The social communication impairments defining autism spectrum disorders (ASD) may be built upon core deficits in perspective-taking, language processing, and self-other representation. Self-referential processing entails the ability to incorporate self-awareness, self-judgment, and self-memory in information processing. Very few studies have examined the neural bases of integrating self-other representation and semantic processing in individuals with ASD. The main objective of this functional MRI study is to examine the role of language and social brain networks in self-other processing in young adults with ASD...
June 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28619522/integrated-analysis-of-paraquat-induced-micrornas-mrnas-changes-in-human-neural-progenitor-cells
#18
Mengling Yan, Tingting Dou, Wen Lv, Xinjin Wang, Lina Zhao, Xiuli Chang, Zhijun Zhou
Paraquat (PQ), one of the most widely used fast-acting and non-selective herbicides in the world is believed to act as a neurotoxicant, which increases the risk of developing Parkinson's disease (PD) by selectively impairing dopaminergic neurons. However, the mechanism of PQ on neural progenitor cells remains unclear. As regulator of mRNA expression, miRNA play a crucial role in neurotoxicity. Based on our previous study, we chose 10μM PQ, which induced ROS production and inhibited proliferation but not reduced the cell viability...
June 12, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28617229/analyzing-the-field-of-bioinformatics-with-the-multi-faceted-topic-modeling-technique
#19
Go Eun Heo, Keun Young Kang, Min Song, Jeong-Hoon Lee
BACKGROUND: Bioinformatics is an interdisciplinary field at the intersection of molecular biology and computing technology. To characterize the field as convergent domain, researchers have used bibliometrics, augmented with text-mining techniques for content analysis. In previous studies, Latent Dirichlet Allocation (LDA) was the most representative topic modeling technique for identifying topic structure of subject areas. However, as opposed to revealing the topic structure in relation to metadata such as authors, publication date, and journals, LDA only displays the simple topic structure...
May 31, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28615059/analysis-of-factors-that-affect-the-precision-of-the-radiographic-lateral-femoral-bowing-angle-using-a-three-dimensional-computed-tomography-based-modelling-technique
#20
Ye-Ran Li, Yu-Hang Gao, Xin Qi, Jian-Guo Liu, Lu Ding, Chen Yang, Zheng Zhang, Shu-Qiang Li
BACKGROUND: Precise measurement of lateral femoral bowing is important to achieve postoperative lower limb alignment. We aimed to investigate factors that affect the precision of the radiographic lateral femoral bowing (RLFB) angle using three-dimensional (3D) models and whether the angle affects surgery design. METHODS: Forty femurs in total were divided into two groups based on their preoperative RLFB angle. The flexion contracture angle, preoperative and postoperative RLFB angles, and intersection angle between the mechanical and anatomical axes were compared...
June 14, 2017: Journal of Orthopaedic Surgery and Research
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