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https://www.readbyqxmd.com/read/27861193/a-comparison-of-surgical-treatments-for-superior-semicircular-canal-dehiscence-a-systematic-review
#1
Fuat Ziylan, Ahmet Kinaci, Andy J Beynon, Henricus P M Kunst
OBJECTIVE: We investigate the postoperative subjective and objective outcomes of different surgical treatments for superior semicircular canal dehiscence (SSCD): vestibular signs, auditory signs, vestibular evoked myogenic potential test, pure tone audiogram, speech audiogram, or video-nystagmography. DATA SOURCES: An electronic search performed in the PubMed, Cochrane Library, and EMBASE databases on 15th of September 2015. A systematic search was conducted. Articles were included if written in English, Dutch, German, or French language...
November 16, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27842540/the-impact-of-low-frequency-low-force-cyclic-stretching-of-human-bronchi-on-airway-responsiveness
#2
Morgan Le Guen, Stanislas Grassin-Delyle, Emmanuel Naline, Amparo Buenestado, Marion Brollo, Elisabeth Longchampt, Philippe Kleinmann, Philippe Devillier, Christophe Faisy
BACKGROUND: In vivo, the airways are constantly subjected to oscillatory strain (due to tidal breathing during spontaneous respiration) and (in the event of mechanical ventilation) positive pressure. This exposure is especially problematic for the cartilage-free bronchial tree. The effects of cyclic stretching (other than high-force stretching) have not been extensively characterized. Hence, the objective of the present study was to investigate the functional and transcriptional response of human bronchi to repetitive mechanical stress caused by low-frequency, low-force cyclic stretching...
November 14, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27834534/vestibular-balance-microvascular-and-white-matter-neuroimaging-characteristics-of-blast-injuries-and-mild-traumatic-brain-injury-four-case-reports
#3
Ramtilak Gattu, Faith W Akin, Anthony T Cacace, Courtney D Hall, Owen D Murnane, E Mark Haacke
BACKGROUND: Case reports are presented on four Veterans, aged 29-46 years, who complained of chronic dizziness and/or postural instability following blast exposures. Two of the four individuals were diagnosed with mild traumatic brain injury and three of the four were exposed to multiple blasts. Comprehensive vestibular, balance, gait, audiometry and neuroimaging procedures were used to characterize their injuries. CASE REPORT: Vestibular assessment included videonystagmography, rotary chair and cervical and ocular vestibular evoked myogenic potentials...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27821617/increased-notch3-activity-mediates-pathological-changes-in-structure-of-cerebral-arteries
#4
Celine Baron-Menguy, Valérie Domenga-Denier, Lamia Ghezali, Frank M Faraci, Anne Joutel
CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), the most frequent genetic cause of stroke and vascular dementia, is caused by highly stereotyped mutations in the NOTCH3 receptor, which is predominantly expressed in vascular smooth muscle. The well-established TgNotch3(R169C) mouse model develops characteristic features of the human disease, with deposition of NOTCH3 and other proteins, including TIMP3 (tissue inhibitor of metalloproteinase 3), on brain vessels, as well as reduced maximal dilation, and attenuated myogenic tone of cerebral arteries, but without elevated blood pressure...
November 7, 2016: Hypertension
https://www.readbyqxmd.com/read/27814311/effects-of-acoustic-stimulus-duration-on-cervical-vestibular-evoked-myogenic-potentials-a-neurophysiological-and-modeling-study
#5
A Ciardo, N El Assawy, S Mauro, L Priano
OBJECTIVE: To analyze and model the effects of acoustic stimulus duration on cervical vestibular evoked myogenic potentials (cVEMPs). DESIGN: Subjects with normal hearing and no vestibular or cervical disorders were tested using 1 kHz tone bursts (TBs) of different durations to evoke cVEMPs from the ipsilateral sternocleidomastoid muscle. VEMP modeling was performed in Labview. RESULTS: The increase in TB duration initially resulted in a non-linear increase in cVEMP amplitude, followed by more complex cVEMP modifications that were mainly related to the appearance of a new wave (nX) that interfered with n23...
November 3, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27802209/comparative-study-between-microvascular-tone-regulation-and-rheological-properties-of-blood-in-patients-with-type-2-diabetes-mellitus
#6
N Antonova, K Tsiberkin, S Podtaev, V Paskova, I Velcheva, N Chaushev
The aim of the study is to investigate the changes of the skin blood flow responses to cold stress in patients with diabetes mellitus type 2 through wavelet analysis of the peripheral skin temperature oscillations and to estimate their relationship with the blood viscosity values. The amplitudes of the skin temperature pulsations (ASTP) were monitored by "Microtest" device ("FM-Diagnostics", Russia); the whole blood viscosity and the shear stresses were measured by Contraves LS30 viscometer, (Switzerland) at a steady flow in 9 healthy subjects and in 30 patients with type 2 diabetes mellitus...
October 12, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27793545/chronic-binge-alcohol-consumption-during-pregnancy-alters-rat-maternal-uterine-artery-pressure-response
#7
Vishal D Naik, Emilie R Lunde-Young, Katie L Davis-Anderson, Marcus Orzabal, Ivan Ivanov, Jayanth Ramadoss
We aimed to investigate pressure-dependent maternal uterine artery responses and vessel remodeling following gestational binge alcohol exposure. Two groups of pregnant rats were used: the alcohol group (28.5% wt/v, 6.0 g/kg, once-daily orogastric gavage in a binge paradigm between gestational day (GD) 5-19) and pair-fed controls (isocalorically matched). On GD20, excised, pressurized primary uterine arteries were studied following equilibration (60 mm Hg) using dual chamber arteriograph. The uterine artery diameter stabilized at 20 mm Hg, showed passive distension at 40 mm Hg, and redeveloped tone at 60 mm Hg...
October 13, 2016: Alcohol
https://www.readbyqxmd.com/read/27789734/elevated-k-channel-activity-opposes-vasoconstrictor-response-to-serotonin-5-ht-in-cerebral-arteries-of-the-fawn-hooded-hypertensive-rat
#8
Mallikarjuna R Pabbidi, Richard J Roman
Previous studies suggest that middle cerebral arteries (MCAs) of Fawn Hooded Hypertensive (FHH) rats exhibit impaired myogenic response and introgression of small region of Brown Norway chromosome 1 containing 15 genes restored the response in FHH.1(BN) congenic rat. The impaired myogenic response in FHH rats is associated with an increase in the activity of the large conductance potassium (BK) channel in vascular smooth muscle cells (VSMCs). The present study examined whether the increased BK channel function in FHH rat alters vasoconstrictor response to serotonin (5-HT)...
October 27, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27787395/comparison-of-different-electrode-configurations-for-the-ovemp-with-bone-conducted-vibration
#9
Robby Vanspauwen, Floris L Wuyts, Stefanie Krijger, Leen K Maes
OBJECTIVES: This study was performed to compare three electrode configurations for the ocular vestibular evoked myogenic potentials (oVEMPs)-"standard," "sternum," and "nose"-by making use of bone-conducted stimuli (at the level of Fz with a minishaker). In the second part, we compared the test-retest reliability of the standard and nose electrode configuration on the oVEMP parameters. DESIGN: This study had a prospective design. Fourteen healthy subjects participated in the first part (4 males, 10 females; average age = 23...
October 26, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/27784066/trpv2-channels-contribute-to-stretch-activated-cation-currents-and-myogenic-constriction-in-retinal-arterioles
#10
Mary K McGahon, José A Fernández, Durga P Dash, Jon McKee, David A Simpson, Alex V Zholos, J Graham McGeown, Tim M Curtis
Purpose: Activation of the transient receptor potential channels, TRPC6, TRPM4, and TRPP1 (PKD2), has been shown to contribute to the myogenic constriction of cerebral arteries. In the present study we sought to determine the potential role of various mechanosensitive TRP channels to myogenic signaling in arterioles of the rat retina. Methods: Rat retinal arterioles were isolated for RT-PCR, Fura-2 Ca2+ microfluorimetry, patch-clamp electrophysiology, and pressure myography studies...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27774319/does-sensory-function-decline-independently-or-concomitantly-with-age-data-from-the-baltimore-longitudinal-study-of-aging
#11
Shekhar K Gadkaree, Daniel Q Sun, Carol Li, Frank R Lin, Luigi Ferrucci, Eleanor M Simonsick, Yuri Agrawal
Objectives. To investigate whether sensory function declines independently or in parallel with age within a single individual. Methods. Cross-sectional analysis of Baltimore Longitudinal Study of Aging (BLSA) participants who underwent vision (visual acuity threshold), proprioception (ankle joint proprioceptive threshold), vestibular function (cervical vestibular-evoked myogenic potential), hearing (pure-tone average audiometric threshold), and Health ABC physical performance battery testing. Results. A total of 276 participants (mean age 70 years, range 26-93) underwent all four sensory tests...
2016: Journal of Aging Research
https://www.readbyqxmd.com/read/27756064/effects-of-allyl-isothiocyanate-acetaminophen-and-dipyrone-in-the-guinea-pig-ileum
#12
Josef Donnerer, Ingrid Liebmann
Allyl isothiocyanate (AITC, mustard oil, 50-200 µmol/l), depending on specific dosages, inhibited the cholinergic twitch response in the longitudinal muscle-myenteric plexus (LMMP) strip of the guinea-pig ileum. AITC also induced short-lasting contractile responses, and decreases of the basal tone of the LMMP strip at low concentrations and increases at high concentrations. Hexamethonium, a blocker of nicotinic ganglionic transmission, was able to prevent the AITC-evoked inhibitory effect, an effect that was also observed with the opioid antagonist naloxone...
October 19, 2016: Pharmacology
https://www.readbyqxmd.com/read/27739592/risk-of-progressive-hearing-loss-in-untreated-superior-semicircular-canal-dehiscence
#13
Neil S Patel, Jacob B Hunter, Brendan P O'Connell, Natalie M Bertrand, George B Wanna, Matthew L Carlson
OBJECTIVE: Patients with incidental or minimally symptomatic superior semicircular canal dehiscence (SSCD) are usually observed, without surgical repair. However, it remains unknown whether a labyrinthine fistula of the superior semicircular canal is associated with progressive conductive or sensorineural hearing loss over time. STUDY DESIGN: Retrospective review at two tertiary care academic referral centers. METHODS: Adults analyzed were diagnosed with SSCD by high-resolution temporal bone computed tomography and vestibular evoked myogenic potential testing and observed with a minimum of two sequential audiograms...
October 14, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27716603/do-vestibular-evoked-myogenic-potential-abnormalities-in-patients-with-cochlear-implant-only-reflect-saccular-dysfunction
#14
Hasan Demirhan, Muhammet Yıldız, Özgür Yiğit
OBJECTIVE: The objective of this study was to explore the usefulness of 1000-Hz tone burst (TB) stimuli for detecting cervical vestibular-evoked myogenic potential (cVEMP) abnormalities in patients with a cochlear implant (CI). MATERIALS AND METHODS: Thirty asymptomatic patients who received unilateral CI because of severe bilateral sensorineural hearing loss were assessed for cVEMP produced by TB stimuli at two frequencies (500 and 1000 Hz) in the airway. VEMPs were recorded when the devices were switched to the on (CI-on) and off (CI-off) positions...
August 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27683672/vascular-mineralocorticoid-receptor-regulates-microrna-155-to-promote-vasoconstriction-and-rising-blood-pressure-with-aging
#15
Jennifer J DuPont, Amy McCurley, Ana P Davel, Joseph McCarthy, Shawn B Bender, Kwangseok Hong, Yan Yang, Jeung-Ki Yoo, Mark Aronovitz, Wendy E Baur, Demetra D Christou, Michael A Hill, Iris Z Jaffe
Hypertension is nearly universal yet poorly controlled in the elderly despite proven benefits of intensive treatment. Mice lacking mineralocorticoid receptors in smooth muscle cells (SMC-MR-KO) are protected from rising blood pressure (BP) with aging, despite normal renal function. Vasoconstriction is attenuated in aged SMC-MR-KO mice, thus they were used to explore vascular mechanisms that may contribute to hypertension with aging. MicroRNA (miR) profiling identified miR-155 as the most down-regulated miR with vascular aging in MR-intact but not SMC-MR-KO mice...
September 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27608722/end-point-indicators-of-low-dose-intra-tympanic-gentamicin-in-management-of-m%C3%A3-ni%C3%A3-re-s-disease
#16
Hong Liu, Ting Zhang, Qianru Wu, Yibo Zhang, Chunfu Dai
CONCLUSIONS: One-shot, low-dose intra-tympanic gentamicin (ITG) treatment was effective and safe for Ménière's disease (MD) patients. Head thrust test (HTT) and vestibular evoked myogenic potentials (VEMPs) test could be used as endpoint indicators for vertigo control in MD patients. OBJECTIVES: The present study is to explore end-point indicators of ITG injection in MD. METHODS: Patients with MD were reviewed from June 2012 to March 2014...
September 9, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27560463/juvenile-growth-reduces-the-influence-of-epithelial-sodium-channels-on-myogenic-tone-in-skeletal-muscle-arterioles
#17
Lori S Kang, Shyama Masilamani, Matthew A Boegehold
Previous studies have documented that rapid juvenile growth is accompanied by functional changes in the arteriolar endothelium, but much less is known about functional changes in arteriolar smooth muscle over this period. In this study, we investigate the possible contribution of epithelial sodium channels (ENaC) to the myogenic behaviour of arterioles at two stages of juvenile growth. The effects of the ENaC inhibitor benzamil on different levels of myogenic tone were studied in isolated gracilis muscle arterioles from rats aged 21-28 days ("weanlings") and 42-49 days ("juveniles")...
December 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27558234/nox4-contributes-to-the-hypoxia-mediated-regulation-of-actin-cytoskeleton-in-cerebrovascular-smooth-muscle
#18
Maha Coucha, Mohammed Abdelsaid, Weiguo Li, Maribeth H Johnson, Laszlo Orfi, Azza B El-Remessy, Susan C Fagan, Adviye Ergul
UNLABELLED: Ischemia/reperfusion and the resulting oxidative/nitrative stress impair cerebral myogenic tone via actin depolymerization. While it is known that NADPH oxidase (Nox) family is a major source of vascular oxidative stress; the extent and mechanisms by which Nox activation contributes to actin depolymerization, and equally important, the relative role of Nox isoforms in this response is not clear. AIM: To determine the role of Nox4 in hypoxia-mediated actin depolymerization and myogenic-tone impairment in cerebral vascular smooth muscle...
October 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27550383/inhibition-of-endoplasmic-reticulum-stress-improves-coronary-artery-function-in-the-spontaneously-hypertensive-rats
#19
Soo-Kyoung Choi, Mihwa Lim, Seon-Hee Byeon, Young-Ho Lee
Endoplasmic reticulum (ER) stress has been shown to play a critical role in the pathogenesis of cardiovascular complications. However, the role and mechanisms of ER stress in hypertension remain unclear. Thus, we hypothesized that enhanced ER stress contributes to the maintenance of hypertension in spontaneously hypertensive rats (SHRs). Sixteen-week old male SHRs and Wistar Kyoto Rats (WKYs) were used in this study. The SHRs were treated with ER stress inhibitor (Tauroursodeoxycholic acid; TUDCA, 100 mg/kg/day) for two weeks...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27525625/detection-of-saccular-endolymphatic-hydrops-in-m%C3%A3-ni%C3%A3-re-s-disease-using-a-modified-glycerol-cvemp-test-in-combination-with-the-tuning-property-test
#20
Toshihisa Murofushi, Sakurako Komiyama, Ryota Suizu
OBJECTIVE: To determine the optimal method for detecting saccular endolymphatic hydrops (EH) in patients with Ménière's disease (MD) using a glycerol cervical vestibular evoked myogenic potential (cVEMP) test in combination with a tuning property test. STUDY DESIGN: Prospective patients series. SETTING: Tertiary referral center. PATIENTS: Twenty-three subjects (age: 36-77 years) were enrolled in this study. Seventeen subjects were diagnosed with definite MD...
September 2016: Otology & Neurotology
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