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https://www.readbyqxmd.com/read/29776866/hearing-impairment-in-type-2-diabetics-and-patients-with-early-diabetic-nephropathy
#1
Jianmin Ren, Fufu Ma, Yujing Zhou, Anting Xu, Jianjian Zhang, Rong Ma, Xiaoyan Xiao
AIMS: The study was to investigate the hearing function in subjects with non-diabetic nephropathy and diabetic nephropathy and analyze related clinical indexes of hearing impairment. METHODS: We assessed the hearing function of 30 diabetics (DM group), 30 patients with early diabetic nephropathy (DN group) and 30 healthy subjects (NC group) using pure-tone audiometry, otoacoustic emissions, electronystagmography, caloric test and cervical vestibular evoked myogenic potential (VEMP)...
April 5, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29764776/vestibulo-cochlear-function-after-cochlear-implantation-in-patients-with-meniere-s-disease
#2
Raquel Manrique-Huarte, Diego Calavia, Laura Alvarez-Gomez, Alicia Huarte, Nicolás Perez-Fernández, Manuel Manrique
OBJECTIVES: To measure the auditory (pure tone audiometry and word recognition scores) and vestibular (video head impulse test and vestibular myogenic potentials) outcomes in patients diagnosed with Meniere's disease (MD) who underwent cochlear implantation. MATERIAL AND METHODS: This prospective study included 23 cochlear implant users with MD and 29 patients diagnosed with far-advanced otosclerosis (the control group). RESULTS: The preoperative mean pure tone average thresholds were 99 and 122...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29757938/piezo1-channel-is-a-potential-regulator-of-synovial-sarcoma-cell-viability
#3
Takahisa Suzuki, Yukiko Muraki, Noriyuki Hatano, Hiroka Suzuki, Katsuhiko Muraki
Detection of mechanical stress is essential for diverse biological functions including touch, audition, and maintenance of vascular myogenic tone. PIEZO1, a mechano-sensing cation channel, is widely expressed in neuronal and non-neuronal cells and is expected to be involved in important biological functions. Here, we examined the possibility that PIEZO1 is involved in the regulation of synovial sarcoma cell-viability. Application of a PIEZO1 agonist Yoda1 effectively induced Ca2+ response and cation channel currents in PIEZO1 -expressing HEK (HEK-Piezo1) cells and synovial sarcoma SW982 (SW982) cells...
May 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29757361/effects-of-rhinoplasty-on-labyrinthine-function
#4
Ahmet Mahmut Tekin, Erkan Soylu, Handan Turan Dizdar, Fahrettin Yilmaz, Yildirim Ahmet Bayazit
Background: Rhinoplasty is a common surgical procedure that is requested and accepted by patients for cosmetic and functional reasons. Osteotomies are performed on nasal bone, maxillary crest, or vomer to fix the deviations of the nasal dorsum or septum. During the percussion of the osteotomes with the surgical mallet, the vibration energy diffuses to the cranium. Auditory and vestibular systems may be affected by these vibrations. Objectives: To assess the effects of rhinoplasty, in which osteotomies were performed using a hammer, on the audiovestibular system...
May 11, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29756401/alpha-1-adrenergic-stimulation-selectively-enhances-endothelium-mediated-vasodilation-in-rat-cremaster-arteries
#5
Ramesh C Mishra, Mohammad M Rahman, Michael J Davis, Heike Wulff, Michael A Hill, Andrew P Braun
We have systematically investigated how vascular smooth muscle α1 -adrenoceptor activation impacts endothelium-mediated vasodilation in isolated, myogenically active, rat cremaster muscle 1A arteries. Cannulated cremaster arteries were pressurized intraluminally to 70 mmHg to induce myogenic tone, and exposed to vasoactive agents via bath superfusion at 34°C. Smooth muscle membrane potential was measured via sharp microelectrode recordings in pressurized, myogenic arteries. The α1 -adrenergic agonist phenylephrine (25-100 nmol/L) produced further constriction of myogenic arteries, but did not alter the vasorelaxant responses to acetylcholine (0...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29748711/calcium-and-voltage-gated-bk-channels-in-vascular-smooth-muscle
#6
REVIEW
Alex M Dopico, Anna N Bukiya, Jonathan H Jaggar
Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In particular, activation of calcium- and voltage-gated potassium channels of large conductance (BK channels) results in outward current that shifts the membrane potential toward more negative values, triggering a negative feed-back loop on depolarization-induced calcium influx and SM contraction. In this short review, we first present the molecular basis of vascular smooth muscle BK channels and the role of subunit composition and trafficking in the regulation of myogenic tone and vascular contractility...
May 11, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29747963/the-possible-effect-of-human-menopausal-gonadotropin-on-the-audio-vestibular-system
#7
Montaser Abdel-Salam, Osama G Abdel-Naby Awad, Mohamed El-Badry, Ahmed Ibrahim, Mahmoud Hosny Ibrahiem
OBJECTIVE: Human menopausal gonadotropin (HMG) is one of the commonest drugs used for ovarian stimulation with no reports on the audio-vestibular system. This study aims to examine HMG on the hearing profile of patients planning intracytoplasmic sperm injection (ICSI). METHODS: This prospective study was conducted from June 2016 to June 2017 in a tertiary referral hospital. The audio-vestibular system of a total of 30 patients was evaluated using pure tone audiometry, distortion product otoacoustic emissions (DPOAEs in the form of a DP-gram) and Vestibular-evoked myogenic potential (VEMP) immediately before therapy and at the day 10 after therapy...
May 7, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29747962/comparison-of-vemps-vhit-and-caloric-test-outcomes-after-vestibular-neurectomy-in-meni%C3%A3-re-s-disease
#8
Andrea Canale, Federico Caranzano, Michele Lanotte, Alessandro Ducati, Francesco Calamo, Andrea Albera, Michelangelo Lacilla, Marco Boldreghini, Sergio Lucisano, Roberto Albera
OBJECTIVE: Selective unilateral vestibular neurectomy (VN) is considered a reliable surgical treatment in case of recurrent vertigo in Menière's disease (MD) because of hearing preservation and a minimally invasive posterior fossa retrosigmoid approach. The present study aimed to assess the quality of life and the long-term vestibular function in patients submitted to yearly follow-up after VN because of intractable MD. METHODS: Retrospective series of 15 MD patients undergoing retrosigmoid VN for recurrent vertigo...
May 7, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29727217/arteriolar-vasodilation-involves-actin-depolymerization
#9
Philip S Clifford, Brian S Ferguson, Jeffrey L Jasperse, Michael A Hill
It is generally assumed that relaxation of arteriolar vascular smooth muscle occurs through hyperpolarization of the cell membrane, reduction in intracellular calcium concentration, and activation of myosin light chain phosphatase/inactivation of myosin light chain kinase. We hypothesized that vasodilation is related to depolymerization of F-actin. Cremaster muscles were dissected from rats under sodium pentobarbital anesthesia (50mg/kg). 1A arterioles were dissected, cannulated on glass micropipettes, pressurized, and warmed to 34{degree sign}C...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29708493/ocular-vestibular-evoked-myogenic-potentials-normative-findings-in-children
#10
Jeffery J Kuhn, Violette H Lavender, Lisa L Hunter, Stephanie E McGuire, Jareen Meinzen-Derr, Robert W Keith, John H Greinwald
BACKGROUND: To add to the limited body of literature on ocular vestibular evoked myogenic potential (oVEMP) responses in children and to assess a different montage for oVEMP recording. PURPOSE: To evaluate the characteristics of the oVEMP response in children and compare the results with that of a group of healthy adults. RESEARCH DESIGN: Prospective descriptive study from a tertiary referral center. STUDY SAMPLE: Twenty-two children (mean age = 6...
May 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29705580/impaired-function-of-cerebral-parenchymal-arterioles-in-experimental-preeclampsia
#11
Abbie C Johnson, Marilyn J Cipolla
Preeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arterioles (PAs) would be impaired during PE. Using a high cholesterol diet to induce experimental PE in rats (ePE), we studied the function and structure of isolated and pressurized PAs supplying frontoparietal WM tracts and cortex and compared to normal pregnant (Preg) and nonpregnant (Nonpreg) Sprague Dawley rats (n = 8/group)...
April 26, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29700616/chronic-inflammatory-demyelinating-polyneuropathy-evaluation-of-the-vestibular-system-with-cervical-and-ocular-vestibular-evoked-myogenic-potentials
#12
Giuseppe Magliulo, Giannicola Iannella, Alessandra Manno, Laura Libonati, Emanuela Onesti, Annarita Vestri, Danilo Alunni Fegatelli, Diletta Angeletti, Annalisa Pace, Giampiero Gulotta, Silvia Gagliardi, Maurizio Inghilleri
PURPOSE: To investigate the possibility of vestibular damage in a group of patients suffering from chronic inflammatory demyelinating polyneuropathy (CIDP) using a diagnostic protocol including the caloric test, C-VEMPs and O-VEMPs. METHODS: Twenty patients suffering from CIDP (mean age 58.5 years, range 33-80 years; 4 women and 16 men) were investigated. To assess any eventual audio-vestibular involvement, all patients of the study underwent pure tone audiometry, Fitzgerald-Hallpike caloric vestibular test, C-VEMPs and O-VEMPs...
April 27, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29698363/relationship-between-audio-vestibular-functional-tests-and-inner-ear-mri-in-meniere-s-disease
#13
Raphaële Quatre, Arnaud Attyé, Alexandre Karkas, Agnès Job, Georges Dumas, Sébastien Schmerber
OBJECTIVES: Meniere's disease is an inner ear disorder generally attributed to an endolymphatic hydrops. Different electrophysiological tests and imaging techniques have been developed to improve endolymphatic hydrops diagnosis. The goal of our study was to compare the sensitivity and the specificity of delayed inner ear magnetic resonance imaging (MRI) after intravenous injection of gadolinium with extratympanic clicks electrocochleography (EcochG), phase shift of distortion product otoacoustic emissions (shift-DPOAEs), and cervical vestibular-evoked myogenic potentials (cVEMP) for the diagnosis of Meniere's disease...
April 25, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29623045/relaxin-deficiency-leads-to-uterine-artery-dysfunction-during-pregnancy-in-mice
#14
Sarah A Marshall, Sevvandi N Senadheera, Maria Jelinic, Kelly O'Sullivan, Laura J Parry, Marianne Tare
The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function and reduced smooth muscle reactivity are factors contributing to uterine artery adaptation and are critical for adequate placental perfusion. The peptide hormone relaxin has an important role in mediating the normal maternal renal vascular adaptations during pregnancy through a reduction in myogenic tone and an increase in flow-mediated vasodilation. Little is known however about the influence of endogenous relaxin on the uterine artery during pregnancy...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29611066/application-of-wavelet-analysis-to-detect-dysfunction-in-cerebral-blood-flow-autoregulation-during-experimental-hyperhomocysteinaemia
#15
Valery V Aleksandrin, Alexander V Ivanov, Edward D Virus, Polina O Bulgakova, Aslan A Kubatiev
The purpose of the present study was to investigate the use of laser Doppler flowmetry (LDF) signals coupled with spectral wavelet analysis to detect endothelial link dysfunction in the autoregulation of cerebral blood flow in the setting of hyperhomocysteinaemia (HHcy). Fifty-one rats were assigned to three groups (intact, control, and HHcy) according to the results of biochemical assays of homocysteine level in blood plasma. LDF signals on the rat brain were recorded by LAKK-02 device to measure the microcirculatory blood flow...
April 3, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29577810/pharmacologic-targeting-of-endothelial-ca-2-activated-k-channels-a-strategy-to-improve-cardiovascular-function
#16
Cini Mathew John, Rayan Khaddaj Mallat, Grace George, Taeyeob Kim, Ramesh C Mishra, Andrew P Braun
Endothelial small and intermediate-conductance, Ca2+ -activated K+ channels (KCa2.3 and KCa3.1, respectively) play an important role in the regulation of vascular function and systemic blood pressure. Growing evidence indicates that they are intimately involved in agonist-evoked vasodilation of small resistance arteries throughout the circulation. Small molecule activators of KCa2.x and 3.1 channels, such as SKA-31, can acutely inhibit myogenic tone in isolated resistance arteries, induce effective vasodilation in intact vascular beds, such as the coronary circulation, and acutely decrease systemic blood pressure in vivo...
March 26, 2018: Channels
https://www.readbyqxmd.com/read/29569212/effect-of-pregnancy-on-cooling-tone-and-rhythmic-contractions-of-the-rat-urinary-bladder
#17
Seham Mustafa
OBJECTIVES: Pregnancy is a physiological alteration that can affect urinary bladder. Cooling of urinary bladder smooth muscle is known as a potent stimulus to micturition due to an increase in muscle tone. The current study investigates the effects of pregnancy on cooling tone and on the rhythmic contractions of the urinary bladder. METHODS: Twenty-four rats were used in this study as control group (non-pregnant) and pregnant group (18-20-day pregnancy). Isolated rat urinary muscle strips were suspended in organ baths containing Krebs' solution for isometric tension recording...
March 22, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29563335/endothelial-cell-pannexin1-modulates-severity-of-ischemic-stroke-by-regulating-cerebral-inflammation-and-myogenic-tone
#18
Miranda E Good, Stephanie A Eucker, Jun Li, Hannah M Bacon, Susan M Lang, Joshua T Butcher, Tyler J Johnson, Ronald P Gaykema, Manoj K Patel, Zhiyi Zuo, Brant E Isakson
Ischemic stroke is a leading cause of morbidity and mortality in the US; however, there currently exists only one effective acute pharmacological therapeutic intervention. Purinergic signaling has been shown to regulate vascular function and pathological processes, including inflammation and arterial myogenic reactivity, and plays a role in ischemic stroke outcome. Purinergic signaling requires extracellular purines; however, the mechanism of purine release from cells is unclear. Pannexin1 (Panx1) channels are potentially novel purine release channels expressed throughout the vascular tree that couples regulated purine release with purinergic signaling...
March 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29560945/-microcirculation-in-patients-with-paranoid-schizophrenia
#19
A V Sakharov, A S Ozornin, S E Golygina, A O Vinogradova, M S Shvets
AIM: To study microcirculation in patients with paranoid schizophrenia by laser Doppler flowmetry. MATERIAL AND METHODS: Fifty-three patients at the age from 18 to 38 years with a diagnosis of 'paranoid schizophrenia' (F20.0) were examined in the acute psychotic state and after 3 weeks of therapy. The control group consisted of 20 healthy volunteers. To assess microcirculation, the noninvasive technique of laser Doppler flowmetry using a laser blood flow analyzer was used...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29466264/effects-of-high-sound-exposure-during-air-conducted-vestibular-evoked-myogenic-potential-testing-in-children-and-young-adults
#20
Amanda I Rodriguez, Megan L A Thomas, Denis Fitzpatrick, Kristen L Janky
OBJECTIVES: Vestibular evoked myogenic potential (VEMP) testing is increasingly utilized in pediatric vestibular evaluations due to its diagnostic capability to identify otolith dysfunction and feasibility of testing. However, there is evidence demonstrating that the high-intensity stimulation level required to elicit a reliable VEMP response causes acoustic trauma in adults. Despite utility of VEMP testing in children, similar findings are unknown. It is hypothesized that increased sound exposure may exist in children because differences in ear-canal volume (ECV) compared with adults, and the effect of stimulus parameters (e...
March 2018: Ear and Hearing
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