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https://www.readbyqxmd.com/read/29035608/f508del-cftr-gene-mutation-in-patients-with-allergic-bronchopulmonary-aspergillosis
#1
Maria N Gamaletsou, Gemma Hayes, Chris Harris, Joanna Brock, Eavan G Muldoon, David W Denning
OBJECTIVE: The F508del mutation occurs in approximately 3.5% of Caucasian population of Northern Europe. Heterozygotes have increased risk for asthma and reduced pulmonary function. Allergic bronchopulmonary aspergillosis (ABPA) is more common in patients with cystic fibrosis (CF). We aimed to establish the frequency of F508del mutation in adult patients with ABPA. METHODS: A retrospective matched case-control study of CF genotyped patients with ABPA seen at the National Aspergillosis Centre was undertaken...
October 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29034528/patients-with-a-new-variant-of-endemic-pemphigus-foliaceus-have-autoantibodies-against-arrector-pili-muscle-colocalizing-with-myzap-p0071-desmoplakins-1-and-2-and-arvcf
#2
A M Abreu-Velez, C A Valencia-Yepes, Y A Upegui-Zapata, E Upegui-Quiceno, N R Mesa-Herrera, J E Velazquez-Velez, M S Howard
BACKGROUND: We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM. METHODS: We took skin biopsies from 30 patients with El Bagre-EPF and 30 healthy controls (HCs) matched by age, sex and occupation, who were all from the endemic area, and tested these using direct immunofluorescence (DIF), confocal microscopy, immunohistochemistry and immunoblotting (IB)...
October 15, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29034405/immunohistochemical-and-serological-characterization-of-membranous-nephropathy-in-children-and-adolescents
#3
Anne K Dettmar, Thorsten Wiech, Markus J Kemper, Armin Soave, Michael Rink, Jun Oh, Rolf A K Stahl, Elion Hoxha
BACKGROUND: Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults, but is less frequent in children. Antibodies against four antigens leading to MN have been described in children: phospholipase A2 receptor 1 (PLA2R1), thrombospondin type-1 domain-containing 7A (THSD7A), neutral endopeptidase (NEP), and cationic bovine serum albumin (BSA). METHODS: Twelve children with MN were included in this study. Sera of all patients were analyzed for antibodies against PLA2R1, THSD7A, NEP, and BSA...
October 15, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29031970/adsorption-equilibrium-and-kinetics-of-immunoglobulin-g-on-a-mixed-mode-adsorbent-in-batch-and-packed-bed-configuration
#4
Pedro Ferreira Gomes, José Miguel Loureiro, Alírio E Rodrigues
It is commonly accepted that efficient protein separation and purification to the desired level of purity is one bottleneck in pharmaceutical industries. MabDirect MM is a new type of mixed mode adsorbent, especially designed to operate in expanded bed adsorption (EBA) mode. In this study, equilibrium and kinetics experiments were carried out for the adsorption of Human Immunoglobulin G (hIgG) protein on this new adsorbent. The effects of ionic strength and pH are assessed. Langmuir isotherms parameters are obtained along with the estimation of the effective pore diffusion coefficient (Dpe) by fitting the batch adsorption kinetics experiments with the pore diffusion model...
October 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29031942/morbidity-in-new-zealand-pesticide-producers-exposed-to-2-3-7-8-tetrachlorodibenzo-p-dioxin-tcdd
#5
Andrea 't Mannetje, Amanda Eng, Chris Walls, Evan Dryson, Jeroen Douwes, Pier Bertazzi, Simon Ryder-Lewis, David Scott, Collin Brooks, Dave McLean, Soo Cheng, Neil Pearce
OBJECTIVES: To conduct a cross-sectional morbidity survey among 245 former employees of a pesticide production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand. METHODS: Demographic factors and health information were collected in face-to-face interviews. TCDD, lipids, thyroid hormones, glucose and immunoglobulin G (IgG) were determined in non-fasting blood. For 111 participants, a neurological examination was conducted. Associations between health outcomes and working in a TCDD exposed job (prevalence 49%) and serum TCDD concentration≥10pg/g lipid (18%) were assessed using logistic regression whilst controlling for age, gender, smoking, body mass index and ethnicity...
October 11, 2017: Environment International
https://www.readbyqxmd.com/read/29030887/the-impact-of-direct-fed-microbials-and-enzymes-on-the-health-and-performance-of-dairy-cows-with-emphasis-on-colostrum-quality-and-serum-immunoglobulin-concentrations-in-calves
#6
S B Ort, K M Aragona, C E Chapman, E Shangraw, A F Brito, D J Schauff, P S Erickson
Thirty-six cows were blocked by calving date and randomly assigned to one of three treatments. Cows were on treatments 3 weeks prepartum through 8 weeks post-partum. Treatments were as follows: (i) no direct-fed microbial (DFM) or cellulase and amylase enzymes (C), (ii) 45.4 g/day of DFM (D) or (iii) 45.4 g/day of DFM and 18.2 g/day of enzyme (DE). Total mixed ration fed and refused were measured daily to determine dry matter intake (DMI). Blood samples were taken three times weekly and analysed for β-hydroxybutyrate, glucose and non-esterified fatty acids...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29029568/quaternized-chitosan-nanoparticles-loaded-with-the-combined-attenuated-live-vaccine-against-newcastle-disease-and-infectious-bronchitis-elicit-immune-response-in-chicken-after-intranasal-administration
#7
Kai Zhao, Shanshan Li, Wei Li, Lu Yu, Xutong Duan, Jinyu Han, Xiaohua Wang, Zheng Jin
Newcastle disease (ND) and infectious bronchitis (IB) are important diseases, which cause respiratory diseases in chickens, resulting in severely economic losses in the poultry industry. In this study, N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) and N,O-carboxymethyl chitosan (CMC) were synthesized as adjuvant and delivery carrier for vaccine antigens. N-2-HACC-CMC/NDV/IBV nanoparticles (NPs) (NDV/La Sota and IBV/H120 encapsulated in N-2-HACC-CMC NPs) and N-2-HACC-CMC/NDV-IBV NPs (the mixing of N-2-HACC-CMC/NDV NPs and N-2-HACC-CMC/IBV NPs in a ratio of 1:1) were prepared by the polyelectrolyte composite method, respectively...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29028159/serologically-diagnosed-acute-human-bocavirus-1-infection-in-childhood-community-acquired-pneumonia
#8
Amanda C Nascimento-Carvalho, Ana-Luisa Vilas-Boas, Maria-Socorro H Fontoura, Man Xu, Tytti Vuorinen, Maria Söderlund-Venermo, Olli Ruuskanen, Cristiana M Nascimento-Carvalho
AIM: To assess the role of human bocavirus 1 (HBoV1) as a causative agent of non-severe community-acquired pneumonia (CAP) in children. METHODS: Patients aged 2-59 months with non-severe CAP (respiratory complaints and radiographic pulmonary infiltrate/consolidation) attending a University Hospital in Salvador, Brazil were enrolled in a prospective cohort. From 820 recruited children in a clinical trial (ClinicalTrials.gov NCT01200706), nasopharyngeal aspirate (NPA), and acute and convalescent serum samples were obtained from 759 (92...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29028118/elevated-serum-adipsin-may-predict-unsuccessful-treatment-for-cows-milk-allergy-but-other-biomarkers-do-not
#9
Susanna Salmivesi, Marita Paassilta, Heini Huhtala, Riina Nieminen, Eeva Moilanen, Matti Korppi
AIM: This study evaluated whether 15 allergy, immunology or inflammatory markers predicted the long-term use of cows' milk or milk products seven years after the start of oral immunotherapy (OIT) for cows' milk allergy in children. METHODS: The following laboratory parameters were measured before the OIT at Tampere University Hospital, Finland, and after the six-month escalation phase: serum total immunoglobulin (Ig) E, milk-specific IgG and IgG4, eosinophil cationic protein, eosinophil-derived neurotoxin, interleukins 4, 5, 6,10 and 12p70 and serum adipokines adiponectin, adipsin, leptin and resistin...
October 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29028117/comparison-of-weight-based-dosing-strategies-for-intravenous-immunoglobulin-in-patients-with-hematologic-malignancies
#10
Sarah E Stump, Allison J Schepers, Alexis R Jones, Maurice D Alexander, Jessica J Auten
STUDY OBJECTIVE: Intravenous immunoglobulin (IVIG) is a weight-based therapy used to treat and prevent infections in patients with hematologic malignancies. Traditionally, IVIG doses have been calculated using actual body weight (ABW). However, limited pharmacokinetic (PK) data suggest dosing strategies using ideal body weight (IBW) or adjusted body weight (adjBW) may be appropriate given the small volume of distribution of IVIG. The objective of this study was to compare the effectiveness of using a precision-dosing strategy (IBW or adjBW) to a traditional-dosing strategy (ABW) for IVIG in patients with hematologic malignancies or those undergoing hematopoietic stem cell transplant, as well as to perform an IVIG drug use analysis...
October 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29025787/a-markov-analysis-of-screening-for-late-onset-cytomegalovirus-disease-in-cytomegalovirus-high-risk-kidney-transplant-recipients
#11
Chethan M Puttarajappa, Sundaram Hariharan, Kenneth J Smith
BACKGROUND AND OBJECTIVES: Management strategies are unclear for late-onset cytomegalovirus infection occurring beyond 6 months of antiviral prophylaxis in cytomegalovirus high-risk (cytomegalovirus IgG positive to cytomegalovirus IgG negative) kidney transplant recipients. Hybrid strategies (prophylaxis followed by screening) have been investigated but with inconclusive results. There are clinical and potential cost benefits of preventing cytomegalovirus-related hospitalizations and associated increased risks of patient and graft failure...
October 12, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29025172/-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-paediatric-patients-with-optic-neuritis
#12
Helmut Tegetmeyer, Andreas Merkenschlager
Background Myelin oligodendrocyte glycoprotein (MOG) is located on the surface of oligodendrocytes and myelin in the central nervous system. MOG-IgG is associated with acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis (NNO), and transverse myelitis (TM) in both paediatric and adult patients. The combination of NNO and TM or other inflammatory brain lesions is a typical feature of neuromyelitis optica spectrum disorders (NMO-SD) which are associated with specific pathogenic autoantibodies against the water channel aquaporin-4 (AQP4-IgG)...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29024606/role-of-the-tslp-dc-ox40l-pathway-in-asthma-pathogenesis-and-airway-inflammation-in-mice
#13
Shuang Feng, Li Zhang, Xu-Hua Bian, Ying Luo, Guang-Hui Qin, Rui-Ming Shi
This study aims to explore the effect of the TSLP/DC/OX40L pathway in asthma pathogenesis and airway inflammation in mice. Sixty-five male BALF/c mice were divided into the control, asthma, IgG + asthma (IgG, 500 g/500 l, intratracheal injection of 50 l each time), LY294002 (OX40L inhibitor) + asthma (intratracheal injection of 2 mg/kg LY294002), and anti-TSLP + asthma (intratracheal injection of 500 ug/500 l TSLP antibody, 50 l each time) groups. ELISA was applied to measure the serum levels of IgE, ovalbumin (OVA)-sIgE, interleukin-4 (IL-4), IL-5, IL-13 and interferon-γ (IFN-γ), flow cytometry was employed to detect Treg cells and dendritic cell (DC) and lymphopoiesis...
October 12, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29024374/human-papillomavirus-and-post-transplant-cutaneous-squamous-cell-carcinoma-a-multicenter-prospective-cohort-study
#14
Jan Nico Bouwes Bavinck, Mariet C W Feltkamp, Adele C Green, Marta Fiocco, Sylvie Euvrard, Catherine A Harwood, Charlotte M Proby, Luigi Naldi, Janouk C D Diphoorn, Anna Venturuzzo, Gianpaolo Tessari, Ingo Nindl, Francesca Sampogna, Damiano Abeni, Rachel E Neale, Jelle J Goeman, Koen D Quint, Anne Berthe Halk, Carmen Sneek, Roel E Genders, Maurits N C de Koning, Wim G V Quint, Ulrike Wieland, Sönke Weissenborn, Tim Waterboer, Michael Pawlita, Herbert Pfister
Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Participants were followed until death or cessation of follow-up in 2016. BetaPV infection was assessed in eyebrow hairs using PCR-based methods. BetaPV IgG seroresponses were determined by multiplex serology...
October 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29023798/intrathecal-antibody-distribution-in-the-rat-brain-surface-diffusion-perivascular-transport-and-osmotic-enhancement-of-delivery
#15
Michelle E Pizzo, Daniel J Wolak, Niyanta N Kumar, Eric Brunette, Christina L Brunnquell, Melanie-Jane Hannocks, N Joan Abbott, M Elizabeth Meyerand, Lydia Sorokin, Danica B Stanimirovic, Robert G Thorne
The precise mechanisms governing the central distribution of macromolecules from the cerebrospinal fluid (CSF) to the brain and spinal cord remain poorly understood, despite their importance for physiological processes such as antibody trafficking for central immune surveillance as well as several ongoing intrathecal clinical trials. Here, we clarify how immunoglobulin G (IgG) and smaller single-domain antibodies (sdAb) distribute throughout the whole brain in a size-dependent manner after intrathecal infusion in rats using ex vivo fluorescence and in vivo 3D magnetic resonance imaging...
October 12, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29022248/coxsackievirus-b4-as-a-causative-agent-of-diabetes-mellitus-type-1-is-there-a-role-of-inefficiently-treated-drinking-water-and-sewage-in-virus-spreading
#16
Waled M El-Senousy, Adel Abdel-Moneim, Mahmoud Abdel-Latif, Mohamed H El-Hefnawy, Rehab G Khalil
This study proposed to detect the enterovirus (EV) infection in children with type 1 diabetes mellitus (T1D) and to assess the role of insufficiently treated water and sewage as sources of viral spreading. Three hundred and eighty-two serum specimens of children with T1D, one hundred serum specimens of children who did not suffer from T1D as control, and forty-eight water and sewage samples were screened for EV RNA using nested RT-PCR. The number of genome copies and infectious units of EVs in raw and treated sewage and water samples were investigated using real-time (RT)-PCR and plaque assay, respectively...
October 11, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/29018834/in-situ-liver-expression-of-hbsag-cd3-bispecific-antibodies-for-hbv-immunotherapy
#17
Robert L Kruse, Thomas Shum, Xavier Legras, Mercedes Barzi, Frank P Pankowicz, Stephen Gottschalk, Karl-Dimiter Bissig
Current therapies against hepatitis B virus (HBV) do not reliably cure chronic infection, necessitating new therapeutic approaches. The T cell response can clear HBV during acute infection, and the adoptive transfer of antiviral T cells during bone marrow transplantation can cure patients of chronic HBV infection. To redirect T cells to HBV-infected hepatocytes, we delivered plasmids encoding bispecific antibodies directed against the viral surface antigen (HBsAg) and CD3, expressed on almost all T cells, directly into the liver using hydrodynamic tail vein injection...
December 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29018057/pd-1-blockade-prevents-the-development-and-progression-of-carcinogen-induced-oral-premalignant-lesions
#18
Jin Wang, Tong-Xin Xie, Bingbing Wang, William N William, John Heymach, Adel K El-Naggar, Jeffrey N Myers, Carlos Caulin
Oral squamous cell carcinoma (OSCC) is preceded by progressive oral premalignant lesions (OPLs). Therefore, therapeutic strategies that prevent malignant progression of OPLs are expected to reduce the incidence of OSCC development. Immune checkpoint inhibitors that target the interaction of programmed death receptor 1 (PD-1) on T cells with the PD-1 ligand PD-L1 on cancer cells have been shown to extend the survival of patients with advanced OSCC. Here, we used the 4-Nitroquinoline-1-oxide (4-NQO) mouse model of oral carcinogenesis to test the hypothesis that PD-1 blockade may control the progression of OPLs...
October 10, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28994166/newer-treatments-of-psoriasis-regarding-il-23-inhibitors-phosphodiesterase-4-inhibitors-and-janus-kinase-inhibitors
#19
REVIEW
Dominika Wcisło-Dziadecka, Martyna Zbiciak-Nylec, Ligia Brzezińska-Wcisło, Katarzyna Bebenek, Agata Kaźmierczak
The rapid progress of genetic engineering furthermore opens up new prospects in the therapy of this difficult-to-treat disease. IL-23 inhibitors, phosphodiesterase 4 (PDE4) inhibitors, and Janus kinase (JAK) inhibitors are currently encouraging further research. Two drugs which are IL-23 inhibitors are now in phase III of clinical trials. The aim of the action of both drugs is selective IL-23 inhibition by targeting the p19 subunit. Guselkumab is a fully human monoclonal antibody. Tildrakizumab is a humanized monoclonal antibody, which also belongs to IgG class and is targeted to subunit p19 of interleukin 23 (IL-23)...
October 10, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28992775/evaluation-of-n-phosphonium-chitosan-as-a-novel-vaccine-carrier-for-intramuscular-immunization
#20
Jianzhou Cai, Wu Zhang, Jiake Xu, Wei Xue, Zonghua Liu
Chitosan, as a potential vaccine delivery material, has obtained much attention for immunization prevention and therapy. However, its poor water solubility brings inconvenience for the practical applications. To address this issue, researchers have carried out many chemical modifications to prepare water-soluble chitosan derivatives for vaccine delivery. In this work, we prepared a chitosan derivative N-phosphonium chitosan with excellent water solubility and explored its potential as an intramuscular vaccine delivery system by using ovalbumin as a model antigen...
January 1, 2017: Journal of Biomaterials Applications
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