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https://www.readbyqxmd.com/read/28822700/full-length-genome-of-a-novel-genotype-3-hepatitis-e-virus-strain-obtained-from-domestic-pigs-in-japan
#1
Putu Prathiwi Primadharsini, Masao Miyake, Satoshi Kunita, Tsutomu Nishizawa, Masaharu Takahashi, Shigeo Nagashima, Tanggis, Hiroshi Ohnishi, Tominari Kobayashi, Takashi Nishiyama, Suljid Jirintai, Hiroaki Okamoto
Hepatitis E virus (HEV) causes acute or chronic hepatitis in humans and can be transmitted via the fecal-oral route. Pigs are one of the main reservoirs for this infection. Sixty pigs, 4-5 months of age, on a swine herd in Japan had detectable anti-HEV IgG antibodies, and five (8.3%) of them had ongoing infection of genotype 3 HEV. Five HEV strains obtained from the viremic pigs shared 98.8-100% nucleotide identity, and one representative strain (swHE1606845), whose entire genomic sequence was determined in this study, differed by 14...
August 16, 2017: Virus Research
https://www.readbyqxmd.com/read/28821293/incidence-and-predictors-of-uveitis-in-juvenile-idiopathic-arthritis-in-a-nordic-long-term-cohort-study
#2
Ellen Nordal, Veronika Rypdal, Terje Christoffersen, Kristiina Aalto, Lillemor Berntson, Anders Fasth, Troels Herlin, Susan Nielsen, Suvi Peltoniemi, Bjørn Straume, Marek Zak, Marite Rygg
BACKGROUND: The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate the incidence and predictors of uveitis in a Nordic population-based cohort. METHODS: Consecutive JIA cases from defined geographical areas in Denmark, Finland, Sweden and Norway with disease onset between January 1997 to June 2000 were followed for median 98 months in this prospective longitudinal cohort study. Potential clinical and immunological predictors of uveitis were identified with logistic regression analysis...
August 18, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28819878/aspergillus-bronchitis-in-patients-with-cystic-fibrosis
#3
Claudia Brandt, Jobst Roehmel, Volker Rickerts, Volker Melichar, Nadja Niemann, Carsten Schwarz
Aspergillus fumigatus frequently colonizes the airways of patients with cystic fibrosis (CF) and may cause various severe infections, such as bronchitis. Serological data, sputum dependent markers and longitudinal data of treated cases of Aspergillus bronchitis were evaluated for further description of this infection. This study, which comprises three substudies, aimed to analyze epidemiological data of Aspergillus in CF and the entity of Aspergillus bronchitis. In a first step, data of the German Cystic Fibrosis Registry were used to evaluate the frequency of Aspergillus colonization in patients with CF (n = 2599)...
August 17, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28818085/a-rare-case-of-acute-toxoplasmosis-in-a-stray-dog-due-to-infection-of-t-gondii-clonal-type-i-public-health-concern-in-urban-settings-with-stray-animals
#4
Sergio Migliore, Salvatore La Marca, Cristian Stabile, Vincenzo Di Marco Lo Presti, Maria Vitale
BACKGROUND: Typing of Toxoplasma gondii strains is important in epidemiological surveys, to understand the distribution and virulence of different clones of the parasite among human and animal populations. Stray dogs can be consider sentinel animals for contaminated environments playing an important but probably under- evaluated role in the epidemiology of T. gondii. We reported a rare case of acute toxoplasmosis in a stray dog due to clonal type I infection. The clonal type I, sporadic in Europe, is frequently associated with severe toxoplasmosis in humans and the control of its circulation is particularly relevant for public health...
August 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28817585/selecting-targets-for-the-diagnosis-of-schistosoma-mansoni-infection-an-integrative-approach-using-multi-omic-and-immunoinformatics-data
#5
Gardenia B F Carvalho, Daniela M Resende, Liliane M V Siqueira, Marcelo D Lopes, Débora O Lopes, Paulo Marcos Z Coelho, Andréa Teixeira-Carvalho, Jeronimo C Ruiz, Cristina T Fonseca
In order to effectively control and monitor schistosomiasis, new diagnostic methods are essential. Taking advantage of computational approaches provided by immunoinformatics and considering the availability of Schistosoma mansoni predicted proteome information, candidate antigens of schistosomiasis were selected and used in immunodiagnosis tests based on Enzime-linked Immunosorbent Assay (ELISA). The computational selection strategy was based on signal peptide prediction; low similarity to human proteins; B- and T-cell epitope prediction; location and expression in different parasite life stages within definitive host...
2017: PloS One
https://www.readbyqxmd.com/read/28814660/sustained-immune-tolerance-induction-in-enzyme-replacement-therapy-treated-crim-negative-patients-with-infantile-pompe-disease
#6
Zoheb B Kazi, Ankit K Desai, Kathryn L Berrier, R Bradley Troxler, Raymond Y Wang, Omar A Abdul-Rahman, Pranoot Tanpaiboon, Nancy J Mendelsohn, Eli Herskovitz, David Kronn, Michal Inbar-Feigenberg, Catherine Ward-Melver, Michelle Polan, Punita Gupta, Amy S Rosenberg, Priya S Kishnani
BACKGROUND: Cross-reactive immunological material-negative (CRIM-negative) infantile Pompe disease (IPD) patients develop an immune response against enzyme replacement therapy (ERT) with alglucosidase alfa that nullifies ERT efficacy. Prophylactic immune tolerance induction (ITI) with rituximab, methotrexate, and IVIG successfully prevents development of deleterious rhGAA IgG antibodies; however, safety, likelihood of success, and long-term efficacy of ITI in a larger cohort remain unknown...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28814229/cell-mediated-and-humoral-immune-responses-to-bordetella-pertussis-inactivated-whole-cells-encapsulated-alginate-microspheres-as-a-new-vaccine-candidate
#7
Naser Mohammadpour Dounighi, Fereshteh Shahcheraghi, Mehdi Razzaghi-Abyaneh, Mojtaba Nofeli, Hossein Zolfagharian
BACKGROUND: Effectiveness of the whole-cell pertussis vaccine is apparent, but improvement in the quality of the vaccine is necessary to achieve strong immunogenicity with a low bacterial number content. METHODS: The inactivated Bordetella pertussis (B. pertussis) cells entrapped microspheres were prepared via an emulsification method and analyzed for morphology, size, size distribution, loading efficiency, loading capacity, release kinetic, in vivo cytokines and antigen specific antibody subclasses...
August 15, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28812057/screening-for-syphilis-in-cases-of-suspected-gonorrhea-and-chlamydia-infections
#8
Kumara V Nibhanipudi, Kenneth Cody
Background. In all cases of suspected sexually transmitted infections (STIs), it has been routine practice to screen for syphilis with a blood sample. The incidence of syphilis seems to be lower than that of commonly screened STIs. Objective. The objective of our study was to determine whether it is cost-effective to screen for syphilis with serological testing in cases of suspected gonorrhea and chlamydia infections. Hypothesis. Our hypothesis is that it is not cost-effective to screen for syphilis in cases of presumed gonorrhea and chlamydia infections...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28810609/value-of-serum-mycoplasma-pneumoniae-immunoglobulin-in-the-diagnosis-of-mycoplasma-related-pneumonia-in-newborns
#9
Yan Dong, Wei Lv, Zhen Lin
Mycoplasma pneumoniae (M. pneumoniae) is an important pathogen of neonatal acquired pneumonia in newborns. Rapid and accurate diagnosis of M. pneumoniae infection is critical because timely antibiotic therapy can reduce drug overuse and prevent the development of bacterial resistance. Anti-M. pneumoniae immunoglobulin M (IgM) is an indicator of early infection that can persist for several months. Studies have shown that anti-M. pneumoniae IgA in adults is a reliable indicator of early M. pneumoniae infection...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808204/safety-immunogenicity-and-cross-species-protection-of-a-plasmid-dna-encoding-plasmodium-falciparum-sera5-polypeptide-microbial-epitopes-and-chemokine-genes-in-mice-and-olive-baboons
#10
Nyamongo Onkoba, Ruth M Mumo, Horace Ochanda, Charles Omwandho, Hastings S Ozwara, Thomas G Egwang
Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of strain-transcending malarial vaccines. The present study sought to determine safety, immunogenicity and cross-species efficacy ofPlasmodium falciparum serine repeat antigen 5 polypeptide co-expressed with epitopes of Bacille-Calmette Guerin (BCG), tetanus toxoid (TT) and a chemokine gene. Olive baboons and BALB/c mice were randomly assigned into vaccine and control groups. The vaccine group animals were primed and boosted twice with pIRES plasmids encoding the SERA5+ BCG+ TT alone, or with either CCL5 or CCL20 and the control group with pIRES plasmid vector backbone...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28805889/oxytocin-injections-in-the-postpartal-period-affect-mammary-tight-junctions-in-sows
#11
C Farmer, M Lessard, C H Knight, H Quesnel
The potential impacts of injecting oxytocin (OXY) to sows in the early postpartum period on the quality of mammary tight junctions, milk composition, and immune status of sows and piglets were studied. Postparturient sows received i.m. injections of either saline (control [CTL]; = 10) or 75 IU of OXY ( = 10). Injections were given twice daily (0800 and 1630 h) starting on d 2 of lactation (i.e., between 12 and 20 h after birth of the last piglet), totaling 4 injections. Milk samples were obtained before the first injection (d 2 morning [AM]), before the second injection (d 2 afternoon [PM]), and on d 4 PM and d 5 PM...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28798286/the-characteristics-and-prognosis-of-diffuse-type-early-gastric-cancer-diagnosed-during-health-check-ups
#12
Ji Young Lee, Eun Jeong Gong, Eun Ju Chung, Hye Won Park, Suh Eun Bae, Eun Hee Kim, Jaeil Kim, Yoon Suh Do, Tae Hyup Kim, Hye-Sook Chang, Ho June Song, Jaewon Choe, Hwoon-Yong Jung
Background/Aims: Because of the poor prognosis of diffuse-type gastric cancer, early detection is important. We investigated the clinical characteristics and prognosis of diffuse-type early gastric cancer (EGC) diagnosed in subjects during health check-ups. Methods: Among 121,111 subjects who underwent gastroscopy during a routine health check-up, we identified 282 patients with 286 EGC lesions and reviewed their clinical and tumor-specific parameters. Results: Patients with diffuse-type EGC were younger, and 48...
August 14, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28797808/influence-of-buffer-solutions-in-the-adsorption-of-human-serum-proteins-onto-layered-double-hydroxide
#13
Diego R Gondim, Juan A Cecilia, Santângela O Santos, Thainá N B Rodrigues, José E Aguiar, Enrique Vilarrasa-García, Enrique Rodríguez-Castellón, Diana C S Azevedo, Ivanildo J Silva
The adsorption of human immunoglobulin G (IgG) and human serum albumin (HSA) on a non-calcined Mg-Al layered double hydroxide (3:1 Mg-Al LDH) was studied in batch and fixed bed experiments, focusing on the effect of buffer solution and pH over sorbent uptake. Mg-Al LDH was synthesized and characterized by X-ray diffraction (XRD), N2 adsorption-desorption isotherms at -196°C, X-ray photoelectron spectroscopy (XPS), Zero point charge (pHzpc), particle size distribution and Fourier transform infra-red (FTIR)...
August 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28797729/vaccination-with-shigella-flexneri-2a-conjugate-induces-type-2a-and-cross-reactive-type-6-antibodies-in-humans-but-not-in-mice
#14
Nahid Farzam, Reut Ramon-Saraf, Yonit Banet-Levi, Liat Lerner-Geva, Shai Ashkenazi, Joanna Kubler-Kielb, Evgeny Vinogradov, John B Robbins, Rachel Schneerson
Shigella flexneri (S. flexneri) 6 has emerged as an important cause of shigellosis. Our efficacy study of Shigella sonnei and S. flexneri 2a O-specific polysaccharide (O-SP) conjugates in 1-4year-olds had too few S. flexneri 2a cases for efficacy evaluation but surprisingly showed protection of 3-4year-olds, S. flexneri 2a-recipients, from S. flexneri 6 infection. To investigate this cross-protection antibodies to both Shigella types were investigated in all sera remaining from previous studies. Twenty to 30% of 3-44year-old humans injected with S...
August 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28797306/seroprevalence-of-influenza-a-and-b-viruses-among-unvaccinated-children-in-the-united-arab-emirates-a-cross-sectional-study
#15
Ahmed R Alsuwaidi, Lolowa A Al-Mekaini, Salwa M Kamal, Hassib Narchi, Abdul-Kader Souid
BACKGROUND: Young children are at increased risk of severe influenza disease and, thus, are good candidates for receiving annual vaccination. Nevertheless, the influenza vaccine is infrequently given to children in our region. The primary objectives of this study are to monitor the serologic immunities against influenza A and B viruses, and provide pediatric data that support the need for influenza vaccination in the community. METHODS: Influenza A and B virus-specific IgG antibodies were measured in 294 children (median age 4...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28796897/hookworm-excretory-secretory-products-modulate-immune-responses-to-heterologous-and-species-specific-antigens
#16
Nicholas Diliani, Blaise Dondji
Approximately one billion people are currently infected with hookworm. Despite its high prevalence and the concomitant immune suppression seen in infected individuals, little research has been done on the mechanism of immunosuppression by hookworm. Our study focused on characterizing mechanisms utilized by hookworm to suppress the host immune response. Splenocytes and draining lymph node cells from mice injected with hookworm excretory/secretory (ES) proteins showed decreased proliferation in response to both heterologous and species-specific antigens while also having increased nitric oxide secretion...
August 10, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28794893/effect-of-dietary-sugar-beet-pulp-supplementation-on-growth-performance-nutrient-digestibility-fecal-microflora-blood-profiles-and-diarrhea-incidence-in-weaning-pigs
#17
C L Yan, H S Kim, J S Hong, J H Lee, Y G Han, Y H Jin, S W Son, S H Ha, Y Y Kim
BACKGROUND: In 2006, the European Union (EU) has decided to forbid use of antibiotics as growth promoters. Although many researches had been conducted about fiber source as alternatives of antibiotics, there are still lack of reports in the literature about the optimum level of sugar beet pulp supplementation, affecting growth performance and nutrient digestibility in weaning pigs. Therefore, different level of sugar beet pulp was added to diets to determine the effects of sugar beet pulp supplementation on growth performance, nutrient digestibility, fecal microflora, blood profile and incidence of diarrhea in weaning pigs...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28793883/cxcl9-a-promising-biomarker-in-the-diagnosis-of-chronic-q-fever
#18
Anne F M Jansen, Teske Schoffelen, Julien Textoris, Jean-Louis Mege, Marrigje Nabuurs-Franssen, Ruud P H Raijmakers, Mihai G Netea, Leo A B Joosten, Chantal P Bleeker-Rovers, Marcel van Deuren
BACKGROUND: In the aftermath of the largest Q fever outbreak in the world, diagnosing the potentially lethal complication chronic Q fever remains challenging. PCR, Coxiella burnetii IgG phase I antibodies, CRP and (18)F-FDG-PET/CT scan are used for diagnosis and monitoring in clinical practice. We aimed to identify and test biomarkers in order to improve discriminative power of the diagnostic tests and monitoring of chronic Q fever. METHODS: We performed a transcriptome analysis on C...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28789852/recombinant-calponin-of-human-filariid-brugia-malayi-secondary-structure-and-immunoprophylactic-potential
#19
Shiv K Verma, Ashish Arora, P Kalpana Murthy
In the search for potential vaccine candidates for the control of human lymphatic filariasis, we recently identified calponin-like protein, that regulates actin/myosin interactions, in a proinflammatory fraction F8 (45.24-48.64kDa) of Brugia malayi adult worms. In the present study, the gene was cloned, expressed, and the recombinant Calponin of B. malayi (r-ClpBm) was prepared and characterized. r-ClpBm bears homology with OV9M of Onchocerca volvulus, a non-lymphatic filariid that causes loss of vision and cutaneous pathology...
August 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28782692/deleterious-impact-of-c3d-binding-donor-specific-anti-hla-antibodies-after-pediatric-liver-transplantation
#20
Eduardo Couchonnal, Christine Rivet, Stéphanie Ducreux, Jérôme Dumortier, Alexie Bosch, Olivier Boillot, Sophie Collardeau-Frachon, Rémi Dubois, Valérie Hervieu, Patrice André, Jean-Yves Scoazec, Alain Lachaux, Valérie Dubois, Olivier Guillaud
BACKGROUND: The prevalence and clinical impact of anti-HLA donor-specific antibodies (DSA) after liver transplantation (LT) have not been extensively studied, especially in pediatric population. METHODS: The present cross-sectional study included 100 patients who underwent a first LT in childhood. Anti HLA immunization study was performed at a single time point during routine follow-up using Luminex® single antigen tests with classical anti-IgG conjugate and anti-C3d conjugate...
August 3, 2017: Transplant Immunology
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