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Uterine factor infertility

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https://www.readbyqxmd.com/read/29330150/dysfunctional-signaling-underlying-endometriosis-current-state-of-knowledge
#1
Yeon Jean Cho, Seung Hyun Lee, Jung Woo Park, Myoungseok Han, Mi Jin Park, Sang Jun Han
Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. It affects approximately 5-10% of women of reproductive age. Endometriosis is associated with dysmenorrhea, dyspareunia and, often, severe pelvic pain. In addition to pain, women with endometriosis often experience infertility. Defining the molecular etiology of endometriosis is a significant challenge for improving the quality of women's lives. Unfortunately, the pathophysiology of endometriosis is not well understood...
January 12, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29306096/embryotoxic-cytokines-potential-roles-in-embryo-loss-and-fetal-programming
#2
REVIEW
Sarah A Robertson, Peck-Yin Chin, Joseph G Femia, Hannah M Brown
Cytokines in the reproductive tract environment at conception mediate a dialogue between the embryo and maternal tissues to profoundly influence embryo development and implantation success. Through effects on gene expression and the cell stress response, cytokines elicit an epigenetic impact with consequences for placental development and fetal growth, which in turn affect metabolic phenotype and long-term health of offspring. There is substantial evidence demonstrating that pro-survival cytokines, such as GM-CSF, CSF1, LIF, HB-EGF and IGFII, support embryos to develop optimally...
December 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29304224/in-vitro-differentiation-of-human-oocyte-like-cells-from-oogonial-stem-cells-single-cell-isolation-and-molecular-characterization
#3
Erica Silvestris, Paola Cafforio, Stella D'Oronzo, Claudia Felici, Franco Silvestris, Giuseppe Loverro
STUDY QUESTION: Are the large cells derived from cultured DEAD box polypeptide 4 (DDX4)-positive oogonial stem cells (OSCs), isolated from the ovarian cortex of non-menopausal and menopausal women, oocyte-like cells? SUMMARY ANSWER: Under appropriate culture conditions, DDX4-positive OSCs from non-menopausal and menopausal women differentiate into large haploid oocyte-like cells expressing the major oocyte markers growth differentiation factor 9 (GDF-9) and synaptonemal complex protein 3 (SYCP3) and then enter meiosis...
January 3, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29276652/endometriosis-epidemiology-diagnosis-and-clinical-management
#4
Parveen Parasar, Pinar Ozcan, Kathryn L Terry
Purpose of review: Endometriosis is a disease of adolescents and reproductive-aged women characterized by the presence of endometrial tissue outside the uterine cavity and commonly associated with chronic pelvic pain and infertility. Here we review the epidemiology of endometriosis as well as potential biomarkers for detection and with the goal of highlighting risk factors that could be used in combination with biomarkers to identify and treat women with endometriosis earlier.. Recent findings: Early age at menarche, shorter menstrual length, and taller height are associated with a higher risk of endometriosis while parity, higher body mass index (BMI) and smoking are associated with decreased risk...
March 2017: Current Obstetrics and Gynecology Reports
https://www.readbyqxmd.com/read/29273681/sorcin-is-involved-during-embryo-implantation-via-activating-vegf-pi3k-akt-pathway-in-mice
#5
Kanchan Gupta, Vijay Kumar Sirohi, Suparna Kumari, Vinay Shukla, Murli Manohar, Pooja Popli, Anila Dwivedi
Earlier studies have demonstrated the cyclic variation and also the altered expression of sorcin in endometrium during early- to mid-secretory phase transition in women with unexplained infertility. The current study was undertaken to establish the functional role of sorcin in endometrial receptivity in mice. Results indicated that sorcin was highly expressed during the window of implantation in mice and functional blockage of sorcin caused significant reduction in number of implanted blastocyst. The receptivity markers (i...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29259482/uterus-transplantation-toward-clinical-application-in-japan
#6
REVIEW
Nobuhiko Suganuma, Ayako Hayashi, Iori Kisu, Kouji Banno, Hisako Hara, Makoto Mihara
Background: In recent years, uterus transplantation (UTx) has been applied as the treatment for patients with uterine factor infertility worldwide. Thus, the clinical application of UTx in Japan should be considered through both the history of UTx technology development in the world and future prospects. Methods: Recent information on UTx was collected via a literature survey and the Internet. Results: Basic research using various animals has been done mainly since 2000...
October 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29242974/effect-of-intramural-fibroid-on-uterine-and-endometrial-vascularity-in-infertile-women-scheduled-for-in-vitro-fertilization
#7
Ahmed Kamel, Akmal El-Mazny, Wafaa Ramadan, Suzy Abdelaziz, Sherine Gad-Allah, Hany Saad, Ahmed M Hussein, Emad Salah
PURPOSE: To study the effect of intramural fibroids on uterine and endometrial vascularity in infertile women scheduled for in-vitro fertilization (IVF). METHODS: 3D power Doppler was used to measure the endometrial volume and blood flow indices in 182 women with intramural fibroids not affecting the uterine cavity and compared them to a matched control group without fibroids. RESULTS: There was significantly increased vascularity in the endometrium of the fibroid group as denoted by higher endometrial VI (p = 0...
December 14, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29242273/rbpj-mediates-uterine-repair-in-the-mouse-and-is-reduced-in-women-with-recurrent-pregnancy-loss
#8
Michael R Strug, Ren-Wei Su, Tae Hoon Kim, Alessandro Mauriello, Carlo Ticconi, Bruce A Lessey, Steven L Young, Jeong Mook Lim, Jae-Wook Jeong, Asgerally T Fazleabas
Unexplained recurrent pregnancy loss (uRPL) is associated with repeated embryo loss and endometrial repair with elevated endometrial expression of inflammatory cytokines, including IFN-γ. Notch signaling through its transcription factor recombination signal binding protein Jκ (RBPJ) regulates mechanisms including the immune response and repair after tissue injury. Initially, null mutation of RBPJ in the mouse uterus (Pgrcre/+Rbpjf/f ; Rbpj c-KO) results in subfertility, but we have found that these mice become infertile after pregnancy as a result of dysfunctional postpartum uterine repair, including delayed endometrial epithelial and myometrial regeneration...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29230527/lefty2-inhibits-endometrial-receptivity-by-downregulating-orai1-expression-and-store-operated-ca2-entry
#9
Madhuri S Salker, Yogesh Singh, Ruban R Peter Durairaj, Jing Yan, Md Alauddin, Ni Zeng, Jennifer H Steel, Shaqiu Zhang, Jaya Nautiyal, Zoe Webster, Sara Y Brucker, Diethelm Wallwiener, B Anne Croy, Jan J Brosens, Florian Lang
Early embryo development and endometrial differentiation are initially independent processes, and synchronization, imposed by a limited window of implantation, is critical for reproductive success. A putative negative regulator of endometrial receptivity is LEFTY2, a member of the transforming growth factor (TGF)-β family. LEFTY2 is highly expressed in decidualizing human endometrial stromal cells (HESCs) during the late luteal phase of the menstrual cycle, coinciding with the closure of the window of implantation...
December 11, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29228447/ethical-and-medico-legal-remarks-on-uterus-transplantation-may-it-solve-uterine-factor-infertility
#10
S Zaami, E Marinelli, N M di Luca, G Montanari Vergallo
Uterus transplantation was firstly tested with animal trials sixty-five years ago. Despite several successful attempts in human subjects, the different procedures still lay at the experimental stage, in need of further studies and investigations before they can be considered as standard clinical practices. Uterus transplant cannot be regarded as a life-saving procedure, but rather a method to restore woman ability to procreate, when lost, thus improving her quality of life. Uterus transplant is a complex surgical procedure and presents significant health threats...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228019/loci-and-pathways-associated-with-uterine-capacity-for-pregnancy-and-fertility-in-beef-cattle
#11
Mahesh Neupane, Thomas W Geary, Jennifer N Kiser, Gregory W Burns, Peter J Hansen, Thomas E Spencer, Holly L Neibergs
Infertility and subfertility negatively impact the economics and reproductive performance of cattle. Of note, significant pregnancy loss occurs in cattle during the first month of pregnancy, yet little is known about the genetic loci influencing pregnancy success and loss in cattle. To identify quantitative trait loci (QTL) with large effects associated with early pregnancy loss, Angus crossbred heifers were classified based on day 28 pregnancy outcomes to serial embryo transfer. A genome wide association analysis (GWAA) was conducted comparing 30 high fertility heifers with 100% success in establishing pregnancy to 55 subfertile heifers with 25% or less success...
2017: PloS One
https://www.readbyqxmd.com/read/29221993/accuracy-of-tubal-patency-assessment-in-diagnostic-hysteroscopy-compared-to-laparoscopy-in-infertile-women-a-retrospective-cohort-study
#12
Regina Promberger, Inga-Malin Simek, Kazem Nouri, Karin Obermaier, Christine Kurz, Johannes Ott
STUDY OBJECTIVE: To evaluate whether the presence of a visualizable "flow" effect in the Fallopian tube ostia in hysteroscopic routine evaluation is predictive of tube patency. DESIGN: Retrospective cohort study (Canadian Task Force Classification II-2) SETTING: Data from all patients who underwent surgery due to infertility at the study center between 2008 and 2016 was analyzed retrospectively. The main outcome parameter was Fallopian tube patency as assessed by laparoscopic chromopertubation...
December 5, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29186429/extracellular-matrix-in-uterine-leiomyoma-pathogenesis-a-potential-target-for-future-therapeutics
#13
Md Soriful Islam, Andrea Ciavattini, Felice Petraglia, Mario Castellucci, Pasquapina Ciarmela
BACKGROUND: Uterine leiomyoma (also known as fibroid or myoma) is the most common benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can produce serious clinical symptoms, including excessive uterine bleeding, pelvic pain or pressure, infertility and pregnancy complications. Due to lack of effective medical treatments surgery has been a definitive choice for the management of this tumor. OBJECTIVE AND RATIONALE: Extracellular matrix (ECM) accumulation and remodeling are thought to be crucial for fibrotic diseases such as uterine leiomyoma...
January 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29184865/etiological-evaluation-of-repeated-biochemical-pregnancy-in-infertile-couples-who-have-undergone-in-vitro-fertilization
#14
Hyun-Mi Lee, Hwa Jeong Lee, Kwang Moon Yang, Sun Hwa Cha, Hyun Kyong Ahn, Young Joo Kim
Objective: This study aims to investigate whether there are any notable etiologies for repeated biochemical pregnancy (RBP) and, if so, to compare those etiologies associated with repeated spontaneous abortion in infertile couples who have undergone in vitro fertilization (IVF). Methods: Forty-four infertile couples who underwent IVF and experienced RBP were included in this study. RBP was defined as more than 2 early pregnancy losses that occurred before the detection of a gestational sac, with ectopic pregnancies specifically excluded by serial serum beta human chorionic gonadotropin evaluation...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29171883/a-call-for-empirical-research-on-uterine-transplantation-and-reproductive-autonomy
#15
Cristie Cole Horsburgh
Uterine transplantation could give women who suffer from uterine factor infertility the possibility of experiencing gestation. Much of the ethical discussion about uterine transplantation has focused on whether research on it should even be pursued, but researchers are nevertheless moving forward with several uterine transplant research protocols. Scholars should therefore already be identifying and engaging in an intimate examination of the ethical realities of offering uterine transplantation in a clinical setting...
December 2017: Hastings Center Report
https://www.readbyqxmd.com/read/29162950/intrauterine-insemination-fundamentals-revisited
#16
EDITORIAL
Gautam N Allahbadia
Intrauterine insemination (IUI) is an assisted conception technique that involves the deposition of a processed semen sample in the upper uterine cavity, overcoming natural barriers to sperm ascent in the female reproductive tract. It is a cost-effective, noninvasive first-line therapy for selected patients with functionally normal tubes, and infertility due to a cervical factor, anovulation, moderate male factor, unexplained factors, immunological factor, and ejaculatory disorders with clinical pregnancy rates per cycle ranging from 10 to 20%...
December 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29157289/vitamin-c-plus-hydrogel-facilitates-bone-marrow-stromal-cell-mediated-endometrium-regeneration-in-rats
#17
Huan Yang, Su Wu, Ran Feng, Junjiu Huang, Lixiang Liu, Feng Liu, Yuqing Chen
BACKGROUND: Intrauterine adhesion (IUA) is a common uterine cavity disease which can be caused by mechanical damage that may eventually lead to infertility and pregnancy abnormalities. Since the effect of therapeutic drugs appears disappointing, cell therapy has emerged as an alternative choice for endometrium regeneration. The aim of this study is to investigate whether the combination of hydrogel Pluronic F-127 (PF-127), Vitamin C (Vc), and a bone marrow stromal cell (BMSC) mixture could be a feasible strategy to improve the endometrial regeneration in a mechanical damage model of IUA in rats...
November 21, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29141456/increased-serum-levels-of-mbdnf-in-women-with-minimal-and-mild-endometriosis-have-no-predictive-power-for-the-disease
#18
Alexandra Perricos, Kazem Ashjaei, Heinrich Husslein, Katharina Proestling, Lorenz Kuessel, Reinhard Obwegeser, Rene Wenzl, Iveta Yotova
The objective of our pilot clinical, prospective study was to determine the serum levels of mature brain-derived neurotrophic factor, in of women with endometriosis and controls and explore whether mature brain-derived neurotrophic factor is a potential biomarker for the disease. The patients were selected from the Endometriosis Marker Austria prospective cohort study conducted at the tertiary referral certified Endometriosis Center of the Medical University of Vienna. All women underwent laparoscopic surgery because there was a suspicion of endometriosis, or the women had pelvic pain, adnexal cysts, unexplained infertility, or uterine fibroids...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29126187/med12-regulates-ovarian-steroidogenesis-uterine-development-and-maternal-effects-in-the-mammalian-egg
#19
Xinye Wang, Priya Mittal, Carlos A Castro, Gabriel Rajkovic, Aleksandar Rajkovic
The transcriptional factor MED12 is part of the essential mediator transcriptional complex that acts as a transcriptional coactivator in all eukaryotes. Missense gain of function mutations in human MED12 are associated with uterine leiomyomas, yet the role of MED12 deficiency in tumorigenesis and reproductive biology has not been fully explored. We generated a Med12 reproductive conditional knockout mouse model to evaluate its role in uterine mesenchyme, granulosa cells, and oocytes. Mice heterozygous for Med12 deficiency in granulosa cells and uterus (Med12fl/+ Amhr2-Cre) were subfertile, while mice homozygous for Med12 deficiency in granulosa cells and uterus (Med12fl/fl Amhr2-Cre) were infertile...
November 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29104078/eucalyptus-robusta-leaves-methanolic-extract-suppresses-inflammatory-mediators-by-specifically-targeting-tlr4-tlr9-mpo-cox2-inos-and-inflammatory-cytokines-in-experimentally-induced-endometritis-in-rats
#20
Aastha Tiwari, Preeti Singh, Pooja Jaitley, Sushant Sharma, Atul Prakash, Rajesh Mandil, Soumen Choudhury, Neeraj Kumar Gangwar, Satish K Garg
ETHNOPHARMACOLOGICAL RELEVANCE: Bacterial endometritis is one of the major causes of reproductive disorders including infertility in farm animals. Antibiotics are generally used for treatment of such disorders but now a days residues of antibiotics are of great public health concern, therefore, phytoremediation is being considered as an alternative to use of antibiotics. AIM OF THE STUDY: Present study was undertaken to investigate the efficacy of Eucalyptus robusta leaves methanolic extract against endometritis along with the possible mechanism of action especially targeting inflammatory biomarkers...
November 2, 2017: Journal of Ethnopharmacology
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