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https://www.readbyqxmd.com/read/28717751/second-primary-cancers-after-primary-breast-cancer-diagnosis-in-israeli-women-1992-to-2006
#1
Barbara G Silverman, Irena Lipshitz, Lital Keinan-Boker
PURPOSE: Improvements in early detection and treatment have resulted in improved long-term survival from breast cancer, which increases the likelihood of the occurrence of second primary cancers. We calculated the risk of second primary cancers among Israeli women receiving a first primary breast cancer diagnosis. METHODS: By using data from the Israel National Cancer Registry, we identified 46,090 women with invasive breast cancer diagnosed between 1990 and 2006 and non-breast primary cancers diagnosed subsequent to breast cancer diagnosis...
April 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716637/update-on-the-management-of-abnormal-uterine-bleeding
#2
Yael Levy-Zauberman, Anne-Gaëlle Pourcelot, Perrine Capmas, Hervé Fernandez
Abnormal uterine bleeding (AUB) is a common complaint that affects large numbers of women from puberty to menopause. It negatively affects health by causing anemia, and impacts the quality of life of women affected. AUB also has an economic impact for both women and society. Therefore, it should not be under- or overestimate and diagnosis, investigations and treatment should be proposed, taking into account the scientific data available in the current state of medical knowledge. Using the new terminology and etiologic classification of AUB is essential to communicate properly around the subject...
July 14, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28715818/first-trimester-combined-multimarker-prospective-study-for-the-detection-of-pregnancies-at-a-high-risk-of-developing-preeclampsia-using-the-fetal-medicine-foundation-algorithm
#3
Meriem Guizani, Joseph Valsamis, Vivien Dutemeyer, Xin Kang, Vera Ceccoti, Joe Khalife, Silvia F Duiella, Frederic Blavier, Alessandra Faraca, Teresa Cos, Jacques C Jani
OBJECTIVE: To evaluate the Fetal Medicine Foundation (FMF) algorithm prospectively at 11-13 weeks' gestation in the prediction of preeclampsia (PE). METHODS: Single-center prospective screening study for PE of singleton pregnancies at 11-13 weeks. The FMF algorithm takes into account maternal characteristics and biomarkers. Detection rate (DR) for a 10% false-positive rate (FPR) for delivery with preterm and term PE was estimated. RESULTS: Between January 2011 and December 2013, of 3,239 patients available for final analysis, 36 (1...
July 18, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28715450/african-genetic-ancestry-interacts-with-body-mass-index-to-modify-risk-for-uterine-fibroids
#4
Ayush Giri, Todd L Edwards, Katherine E Hartmann, Eric S Torstenson, Melissa Wellons, Pamela J Schreiner, Digna R Velez Edwards
Race, specifically African ancestry, and obesity are important risk factors for uterine fibroids, and likely interact to provide the right conditions for fibroid growth. However, existing studies largely focus on the main-effects rather than their interaction. Here, we firstly provide evidence for interaction between categories of body mass index (BMI) and reported-race in relation to uterine fibroids. We then investigate whether the association between inferred local European ancestry and fibroid risk is modified by BMI in African American (AA) women in the Vanderbilt University Medical Center bio-repository (BioVU) (539 cases and 794 controls) and the Coronary Artery Risk Development in Young Adults study (CARDIA, 264 cases and 173 controls)...
July 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28714779/serum-free-placental-growth-factor-isoform-1-at-11-13-week-gestation-effects-of-maternal-factors-mean-arterial-pressure-placental-volume-and-uterine-artery-pulsatility-index
#5
Maolee Bhuwapathanapun, Busadee Pratumvinit, Piyaporn Lahfahroengron, Sithikan Hanyongyuth, Amprapha Phaophan, Julaporn Pooliam, Tuangsit Wataganara
INTRODUCTION: To define the effects of maternal factors, mean arterial pressure (MAP), placental volume (PV), and uterine artery Doppler pulsatility index (UtAPI) to serum level of free form of placental growth factor isoform 1 (free PlGF-1) measured with a novel automated assay. METHODS: We enrolled 200 Thai women singleton pregnancy from 11(+0) to 13(+6) weeks gestation with low prior risk maternal factors (age, parity, tobacco use, assisted reproductive technology, and body mass index)...
July 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28714317/prospective-observational-study-to-determine-the-accuracy-of-first-trimester-serum-biomarkers-and-uterine-artery-dopplers-in-combination-with-maternal-characteristics-and-arteriography-for-the-prediction-of-women-at-risk-of-preeclampsia-and-other-adverse-pregnancy
#6
Rebecca Allen, Joseph Aquilina
OBJECTIVES: To assess the efficacy of biomarkers, arteriography and uterine artery Dopplers for predicting hypertensive disease of pregnancy, small for gestational age and stillbirth. METHODS: This was a prospective first trimester study. Ultrasound was used to assess uterine artery Doppler. Maternal arteriography performed and serum taken for measurement of placental growth factor (PlGF), alpha fetoprotein (AFP), pregnancy associated plasma protein (PAPP-A) and beta human chorionic gonadotrophin (β-hCG) levels...
July 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28710882/mid-trimester-preterm-premature-rupture-of-membranes-pprom-etiology-diagnosis-classification-international-recommendations-of-treatment-options-and-outcome
#7
REVIEW
Michael Tchirikov, Natalia Schlabritz-Loutsevitch, James Maher, Jörg Buchmann, Yuri Naberezhnev, Andreas S Winarno, Gregor Seliger
Mid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal membranes prior to 28 weeks of gestation, complicates approximately 0.4%-0.7% of all pregnancies. This condition is associated with a very high neonatal mortality rate as well as an increased risk of long- and short-term severe neonatal morbidity. The causes of the mid-trimester PPROM are multifactorial. Altered membrane morphology including marked swelling and disruption of the collagen network which is seen with PPROM can be triggered by bacterial products or/and pro-inflammatory cytokines...
July 15, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28709703/extent-of-lymphovascular-space-invasion-may-predict-lymph-node-metastasis-in-uterine-serous-carcinoma
#8
Yushen Qian, Erqi L Pollom, Chika Nwachukwu, Kira Seiger, Rie von Eyben, Ann K Folkins, Elizabeth A Kidd
OBJECTIVES: Emerging evidence suggests that extent of lymphovascular space invasion (LVSI) predicts for risk of lymph node metastasis in endometrioid uterine cancers. However, this correlation remains unknown in the setting of uterine serous carcinoma (USC). We sought to examine the association between extent of LVSI and other histopathologic characteristics with risk of nodal metastasis for women with USC. MATERIALS/METHODS: Pathological data from all cases of uterine serous carcinoma between July 1998 to July 2015 at our institution were reviewed...
July 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28709581/trends-in-end-of-life-care-and-healthcare-spending-in-women-with-uterine-cancer
#9
Benjamin Margolis, Ling Chen, Melissa K Accordino, Grace Clarke Hillyer, June Y Hou, Ana I Tergas, William M Burke, Alfred I Neugut, Cande V Ananth, Dawn L Hershman, Jason D Wright
BACKGROUND: High intensity care including hospitalizations, chemotherapy and other interventions at the end of life is costly and often of little value for cancer patients. Little is known about patterns of end of life care and resource utilization for women with uterine cancer. OBJECTIVE: We examined the costs and predictors of aggressive end of life care for women with uterine cancer. METHODS: In this observational cohort study the Surveillance, Epidemiology and End Results-Medicare linked database was used to identify women >65 who died from uterine cancer from 2000-2011...
July 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28708788/therapy-modalities-prognostic-factors-and-outcome-of-the-primary-cervical-carcinosarcoma-meta-analysis-of-extremely-rare-tumor-of-cervix
#10
Gunsu Kimyon Comert, Osman Turkmen, Alper Karalok, Derman Basaran, Dilek Bulbul, Taner Turan
OBJECTIVE: The aim of this study was to evaluate the prognostic factors, treatment options, and survival outcomes of primary carcinosarcomas of the uterine cervix. METHODS: An electronic search of the literature was conducted from 1951 to February 2017 to identify articles on primary cervical carcinosarcoma. After comprehensive evaluation of case series and case reports, 81 cases were included in the study. RESULTS: The most common clinical FIGO (International Federation of Gynecology and Obstetrics) stage was IB at 53% of cases...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708506/expression-and-localization-of-cyclooxygenases-in-the-oviduct-of-laying-hens-during-the-ovulatory-cycle
#11
M Elhamouly, N Isobe, Y Yoshimura
Prostaglandins (PGs) play important roles in regulation of the functions of the hen oviduct. However, little is known about the expression and localization of the rate-limiting cyclooxygenases (COX-1 and COX-2) in the oviduct. The aim of this study was to determine the COXs expression and localization in the different segments of the oviduct and to investigate changes in their expression levels during the ovulatory cycle of laying hens. White Leghorn laying hens were killed at 0, 4, 7, 16 and 24 h after oviposition, and samples from the infundibulum, magnum, isthmus, uterus, and vagina were collected...
June 13, 2017: Theriogenology
https://www.readbyqxmd.com/read/28707146/association-between-g1733a-rs6152-polymorphism-in-androgen-receptor-gene-and-recurrent-spontaneous-abortions-in-mexican-population
#12
Ángela Porras-Dorantes, Aniel Jessica Leticia Brambila-Tapia, Alma Benita Lazcano-Castellanos, Thiago Donizete Da Silva-José, Jesús Alejandro Juárez-Osuna, José Elías García-Ortiz
INTRODUCTION: Recurrent spontaneous abortion (RSA) is a multifactorial condition that occurs with a frequency of 0.2-5% in women of reproductive age. Among genetic factors, the single nucleotide polymorphism (SNP) G1733A in the androgen receptor (AR) gene has been associated with its presence in Greek and Iranian populations. Therefore, the aim of this study is to determine its possible association with RSA in this population. PATIENTS AND METHODS: A total of 156 Mexican RSA (with at least 2 consecutive abortions) unrelated patients and 152 unrelated healthy women were included, the presence of karyotype anomalies in the parents as well as uterine anomalies as well as antiphospholipid antibodies was excluded in patients; while all the controls presented at least two healthy pregnancies and no abortion...
July 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28706457/relaxant-and-anti-inflammatory-effect-of-two-thalidomide-analogs-as-pde-4-inhibitors-in-pregnant-rat-uterus
#13
Víctor Manuel Muñoz-Pérez, Eduardo Fernández-Martínez, Héctor Ponce-Monter, Mario I Ortiz
The aim of this study was to evaluate the relaxant and anti-inflammatory effects of two thalidomide analogs as phosphodiesterase-4 (PDE-4) inhibitors in pregnant rat uterus. Uteri from Wistar female rats were isolated at 19 day of pregnancy. Uterine samples were used in functional studies to evaluate the inhibitory effects of the thalidomide analogs, methyl 3-(4-nitrophthalimido)-3-(3,4-dimethoxyphenyl)-propanoate (4NO2PDPMe) and methyl 3-(4-aminophthalimido)-3-(3,4-dimethoxyphenyl)-propanoate (4APDPMe), on prostaglandin-F2α (PGF2α)-induced phasic, K(+)-induced tonic, and Ca(2+)-induced contractions...
July 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28704345/the-effects-and-possible-mechanisms-of-puerarin-to-treat-uterine-fibrosis-induced-by-ischemia-reperfusion-injury-in-rats
#14
Lin Lin, Yi He, Jiashu Zhang, Qi Liu, Lixia Wang
BACKGROUND Tissues fibrosis is caused by ischemia-reperfusion injury (IRI) and results in organ dysfunction. In this study, we aimed to investigate whether fibrosis occurs after uterine ischemia-reperfusion injury, and to investigate the effects of puerarin (Pur) on the fibrosis process in rats. MATERIAL AND METHODS Twenty-four female Wistar rats were randomly divided into three groups (8 in each group): the control group rats only received operation without uterine ischemic, the IRI group and the IRI + Pur group rats received 30-minutes ischemia and 2-weeks of reperfusion...
July 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28702255/diabetes-and-its-drivers-the-largest-epidemic-in-human-history
#15
EDITORIAL
Paul Z Zimmet
The "Diabesity" epidemic (obesity and type 2 diabetes) is likely to be the biggest epidemic in human history. Diabetes has been seriously underrated as a global public health issue and the world can no longer ignore "the rise and rise" of type 2 diabetes. Currently, most of the national and global diabetes estimates come from the IDF Atlas. These estimates have significant limitations from a public health perspective. It is apparent that the IDF have consistently underestimated the global burden. More reliable estimates of the future burden of diabetes are urgently needed...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/28698006/identification-of-tradd-as-a-potential-biomarker-in-human-uterine-leiomyoma-through-itraq-based-proteomic-profiling
#16
Yong Liu, Dan Lu, Jie Sheng, Lijing Luo, Weiyuan Zhang
Recurrent and refractory leiomyoma of uterus is one of the most common diseases in women of reproductive age. Despite its benign nature, uterine leiomyoma has presented an extremely deleterious impact on public health. The etiology of uterine leiomyoma remains unclear and clinical management remains suboptimal, leaving radical hysterectomy the only effective approach. Delineating the molecular mechanism underlying the leiomyoma initiation and progression remains an unmet clinical need. To screen proteins that were differentially expressed in uterine leiomyoma versus normal myometrium, we examined proteomic profile by isobaric tag for relative and absolute quantitation (iTRAQ) labeling coupled with liquid chromatography - tandem mass spectrometry (LC-MS/MS)...
July 8, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28697115/selective-progesterone-receptor-modulators-for-the-treatment-of-uterine-leiomyomas
#17
Myriam Safrai, Henry H Chill, Adi Reuveni Salzman, Asher Shushan
Uterine leiomyomas have drawn much attention since being described more than 200 years ago. These common benign uterine tumors often present with prolonged menstrual bleeding, pelvic pressure, and reproductive disorders and pose a true financial burden on health care systems all over the world. Over the past few decades, surgical treatment of uterine leiomyomas has received most of the focus compared with other treatment options. Choosing the appropriate surgical technique depends on many factors such as uterine leiomyoma location, patient's age, interest in future fertility, concomitant comorbidities, and the patient's preference...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28697106/readmission-after-gynecologic-surgery-a-comparison-of-procedures-for-benign-and-malignant-indications
#18
Lori Cory, Nawar Latif, Colleen Brensinger, Xiaochen Zhang, Robert L Giuntoli, Robert A Burger, Mark Morgan, Emily Ko
OBJECTIVE: To compare 30-day postsurgical readmission rates and associated risk factors for readmission among women undergoing gynecologic surgery for benign and malignant conditions. METHODS: In a retrospective cohort study, we identified patients after surgery for benign and malignant gynecologic conditions in the National Surgical Quality Improvement Program database between January 1, 2011, and December 31, 2012. Data collected included surgical factors, perioperative characteristics, surgical complications, and 30-day readmissions...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28696852/imaging-of-pregnancy-related-vascular-complications
#19
R Scooter Plowman, Cylen Javidan-Nejad, Constantine A Raptis, Douglas S Katz, Vincent M Mellnick, Sanjeev Bhalla, Patricia Cornejo, Christine O Menias
Pregnancy results in substantial hemodynamic and prothrombotic changes that form the foundation for downstream vascular complications, both during pregnancy and in the postpartum period. In addition, several important risk factors, including older patient age, diabetes, and smoking, can increase the risk for vascular-related pregnancy complications. Because radiologists often play an important role in evaluation of the pregnant patient, understanding the pathophysiology of vascular-related complications in pregnancy and their imaging appearances is essential for diagnostic accuracy...
July 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28694860/postpartum-aortic-bifurcation-thrombosis-on-the-background-of-thrombophilic-disorder
#20
Roxana Elena Bohîltea, Natalia Turcan, Horia Muresian, Silvia Condu, Elvira Bratila, Monica Mihaela Cîrstoiu
Two main causes of arterial thrombosis are known: fi rst - atherosclerosis, extensively studied, and the second - atrial fi brillation. The lack of any risk factors and the occurrence at young age of a thrombotic event requires us to investigate possible other conditions, including inherited thrombophilia that is represented by a series of genetic disorders that increase the risk of thromboembolic disease. The role of thrombophilia in the occurrence of arterial thrombosis is inconsequential; this disorder is characterized by the tendency of developing venous thrombosis...
September 2016: Mædica
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