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Functional electric stimulation

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https://www.readbyqxmd.com/read/28213469/insulin-signaling-via-the-pi3k-akt-pathway-regulates-airway-glucose-uptake-and-barrier-function-in-a-cftr-dependent-manner
#1
Samuel A Molina, Hannah K Moriarty, Danny T Infield, Barry R Imhoff, Rachel J Vance, Agnes H Kim, Jason M Hansen, William R Hunt, Michael Koval, Nael A McCarty
Cystic fibrosis-related diabetes (CFRD) is the most common co-morbidity associated with cystic fibrosis (CF) and correlates with increased rates of lung function decline. Since glucose is a nutrient present in the airways of patients with bacterial airway infections and since insulin controls glucose metabolism, the effect of insulin on CF airway epithelia was investigated to determine the role of insulin receptors and glucose transport in regulating glucose availability in the airway. The response to insulin by human airway epithelial cells was characterized by qPCR, immunoblot, immunofluorescence, and glucose uptake assays...
February 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28213205/sensory-trigeminal-ulf-tens-stimulation-reduces-hrv-response-to-experimentally-induced-arithmetic-stress-a-randomized-clinical-trial
#2
Monaco Annalisa, Cattaneo Ruggero, Ortu Eleonora, Constantinescu Marian Vladimir, Pietropaoli Davide
Ultra Low Frequency Transcutaneous Electric Nervous Stimulation (ULF-TENS) is extensively used for pain relief and for the diagnosis and treatment of temporomandibular disorders (TMD). In addition to its local effects, ULF-TENS acts on the autonomic nervous system (ANS), with particular reference to the periaqueductal gray (PAG), promoting the release of endogenous opioids and modulating descending pain systems. It has been suggested that the PAG participates in the coupling between the emotional stimulus and the appropriate behavioral autonomic response...
February 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28211795/a-murine-model-of-a-novel-surgical-architecture-for-proprioceptive-muscle-feedback-and-its-potential-application-to-control-of-advanced-limb-prostheses
#3
Tyler R Clites, Matthew Carty, Shriya Srinivasan, Anthony Zorzos, Hugh Herr
<i>Objective:</i> Proprioceptive mechanisms play a critical role in both reflexive and volitional lower extremity control. Significant strides have been made in the development of bionic limbs that are capable of bi-directional communication with the peripheral nervous system, but none of these systems have been capable of providing physiologically-relevant muscle-based proprioceptive feedback through natural neural pathways. In this study, we present the Agonist-antagonist Myoplastic Interface (AMI), a surgical approach with the capacity to provide graded kinesthetic feedback from a prosthesis through mechanical activation of native mechanoreceptors within residual agonist-antagonist muscle pairs...
February 17, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28210068/use-of-an-arm-weight-bearing-combined-with-upper-limb-reaching-apparatus-to-facilitate-motor-paralysis-recovery-in-an-incomplete-spinal-cord-injury-patient-a-single-case-report
#4
Takashi Hoei, Kazumi Kawahira, Hidefumi Fukuda, Keizo Sihgenobu, Megumi Shimodozono, Tadashi Ogura
[Purpose] Training using an arm weight-bearing device combined with upper-limb reaching apparatus to facilitate motor paralysis recovery, named the "Reaching Robot", as well as Repetitive Facilitation Exercise were applied to a patient with severe impairment of the shoulder and elbow due to incomplete spinal cord injury and the effects were examined. [Subjects and Methods] A 66-year-old man with incomplete spinal cord injury participated in an upper extremity rehabilitation program involving a Reaching Robot...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28209965/high-amplitude-electrical-stimulation-can-reduce-elicited-neuronal-activity-in-visual-prosthesis
#5
Alejandro Barriga-Rivera, Tianruo Guo, Chih-Yu Yang, Amr Al Abed, Socrates Dokos, Nigel H Lovell, John W Morley, Gregg J Suaning
Retinal electrostimulation is promising a successful therapy to restore functional vision. However, a narrow stimulating current range exists between retinal neuron excitation and inhibition which may lead to misperformance of visual prostheses. As the conveyance of representation of complex visual scenes may require neighbouring electrodes to be activated simultaneously, electric field summation may contribute to reach this inhibitory threshold. This study used three approaches to assess the implications of relatively high stimulating conditions in visual prostheses: (1) in vivo, using a suprachoroidal prosthesis implanted in a feline model, (2) in vitro through electrostimulation of murine retinal preparations, and (3) in silico by computing the response of a population of retinal ganglion cells...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28207578/the-impact-of-a-cochlear-implant-electrode-array-on-the-middle-ear-transfer-function
#6
David Pazen, Andreas Anagiotos, Maike Nünning, Antoniu-Oreste Gostian, Magdalene Ortmann, Dirk Beutner
OBJECTIVES: As a treatment for partial deafness with residual hearing in the lower frequency range, the combined acoustic and electric stimulation of the cochlea has become widespread. Acoustic stimulation is provided by a hearing aid's airborne sound and the electric stimulation by a cochlear implant electrode array, which may be inserted through the round window or a cochleostomy. To take advantage of that concept, it is essential to preserve residual hearing after surgery. Therefore, the intracochlear electrode array should not compromise the middle ear vibration transmission...
February 15, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28197198/application-of-a-paraplegic-gait-orthosis-in-thoracolumbar-spinal-cord-injury
#7
Lang Shuai, Guo-Hua Yu, Zhen Feng, Wan-Song Wang, Wei-Ming Sun, Lu Zhou, Yin Yan
Paraplegic gait orthosis has been shown to help paraplegic patients stand and walk, although this method cannot be individualized for patients with different spinal cord injuries and functional recovery of the lower extremities. There is, however, a great need to develop individualized paraplegic orthosis to improve overall quality of life for paraplegic patients. In the present study, 36 spinal cord (below T4) injury patients were equally and randomly divided into control and observation groups. The control group received systematic rehabilitation training, including maintenance of joint range of motion, residual muscle strength training, standing training, balance training, and functional electrical stimulation...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28194746/stimuli-responsive-polymeric-nanocarriers-for-efficient-gene-delivery
#8
REVIEW
Yingqin Li, Jinbiao Gao, Chao Zhang, Zhong Cao, Du Cheng, Jie Liu, Xintao Shuai
Gene therapy provides an alternative and effective method for treatment of genetic diseases and cancers that are refractory to conventional therapeutics. The success of gene therapy is largely dependent on the development of safe and effective gene delivery vectors for transporting genetic material from the blood stream to the cytoplasm or nucleus. Current gene vectors can be divided into viral and non-viral vectors. Although non-viral gene delivery carriers can offer some advantages, such as safety and facile fabrication, they do not possess the same high gene transfection efficiency as viral vectors due to a lack of functionality to overcome extra- and intracellular gene delivery obstacles...
April 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28194098/spatiotemporal-profiles-of-proprioception-processed-by-the-masseter-muscle-spindles-in-rat-cerebral-cortex-an-optical-imaging-study
#9
Satoshi Fujita, Mari Kaneko, Hiroko Nakamura, Masayuki Kobayashi
Muscle spindles in the jaw-closing muscles, which are innervated by trigeminal mesencephalic neurons (MesV neurons), control the strength of occlusion and the position of the mandible. The mechanisms underlying cortical processing of proprioceptive information are critical to understanding how sensory information from the masticatory muscles regulates orofacial motor function. However, these mechanisms are mostly unknown. The present study aimed to identify the regions that process proprioception of the jaw-closing muscles using in vivo optical imaging with a voltage-sensitive dye in rats under urethane anesthesia...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28193579/zinc-enhances-intestinal-epithelial-barrier-function-through-the-pi3k-akt-mtor-signaling-pathway-in-caco-2-cells
#10
Yuxin Shao, Patricia G Wolf, Shuangshuang Guo, Yuming Guo, H Rex Gaskins, Bingkun Zhang
Zinc plays an important role in maintaining intestinal barrier function as well as modulating cellular signaling recognition and protein kinase activities. The phosphatidylinositol 3-kinase (PI3K) cascade has been demonstrated to affect intercellular integrity and tight junction (TJ) proteins. The current study investigated the hypothesis that zinc regulates intestinal intercellular junction integrity through the PI3K/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. A transwell model of Caco-2 cell was incubated with 0, 50 and 100 μM of zinc at various time points...
January 31, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28192130/ielvis-an-open-source-matlab-toolbox-for-localizing-and-visualizing-human-intracranial-electrode-data
#11
David M Groppe, Stephan Bickel, Andrew R Dykstra, Xiuyuan Wang, Pierre Mégevand, Manuel R Mercier, Fred A Lado, Ashesh D Mehta, Christopher J Honey
BACKGROUND: Intracranial electrical recordings (iEEG) and brain stimulation (iEBS) are invaluable human neuroscience methodologies. However, the value of such data is often unrealized as many laboratories lack tools for localizing electrodes relative to anatomy. To remedy this, we have developed a MATLAB toolbox for intracranial electrode localization and visualization, iELVis. NEW METHOD: iELVis uses existing tools (BioImage Suite, FSL, and FreeSurfer) for preimplant magnetic resonance imaging (MRI) segmentation, neuroimaging coregistration, and manual identification of electrodes in postimplant neuroimaging...
February 9, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28192079/electrical-neuromodulation-of-the-cervical-spinal-cord-facilitates-forelimb-skilled-function-recovery-in-spinal-cord-injured-rats
#12
Monzurul Alam, Guillermo Garcia-Alias, Benita Jin, Jonathan Keyes, Hui Zhong, Roland R Roy, Yury Gerasimenko, Daniel C Lu, V Reggie Edgerton
Enabling motor control by epidural electrical stimulation of the spinal cord is a promising therapeutic technique for the recovery of motor function after a spinal cord injury (SCI). Although epidural electrical stimulation has resulted in improvement in hindlimb motor function, it is unknown whether it has any therapeutic benefit for improving forelimb fine motor function after a cervical SCI. We tested whether trains of pulses delivered at spinal cord segments C6 and C8 would facilitate the recovery of forelimb fine motor control after a cervical SCI in rats...
February 9, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28191886/sirtuin-1-regulates-cardiac-electrical-activity-by-deacetylating-the-cardiac-sodium-channel
#13
Ajit Vikram, Christopher M Lewarchik, Jin-Young Yoon, Asma Naqvi, Santosh Kumar, Gina M Morgan, Julia S Jacobs, Qiuxia Li, Young-Rae Kim, Modar Kassan, Jing Liu, Mohanad Gabani, Ajay Kumar, Haider Mehdi, Xiaodong Zhu, Xiaoqun Guan, William Kutschke, Xiaoming Zhang, Ryan L Boudreau, Shengchuan Dai, Daniel S Matasic, Saet-Byel Jung, Kenneth B Margulies, Vikas Kumar, Markus M Bachschmid, Barry London, Kaikobad Irani
The voltage-gated cardiac Na(+) channel (Nav1.5), encoded by the SCN5A gene, conducts the inward depolarizing cardiac Na(+) current (INa) and is vital for normal cardiac electrical activity. Inherited loss-of-function mutations in SCN5A lead to defects in the generation and conduction of the cardiac electrical impulse and are associated with various arrhythmia phenotypes. Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1...
February 13, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28191352/hybrid-assistive-neuromuscular-dynamic-stimulation-therapy-a-new-strategy-for-improving-upper-extremity-function-in-patients-with-hemiparesis-following-stroke
#14
REVIEW
Toshiyuki Fujiwara, Michiyuki Kawakami, Kaoru Honaga, Michi Tochikura, Kaoru Abe
Hybrid Assistive Neuromuscular Dynamic Stimulation (HANDS) therapy is one of the neurorehabilitation therapeutic approaches that facilitates the use of the paretic upper extremity (UE) in daily life by combining closed-loop electromyography- (EMG-) controlled neuromuscular electrical stimulation (NMES) with a wrist-hand splint. This closed-loop EMG-controlled NMES can change its stimulation intensity in direct proportion to the changes in voluntary generated EMG amplitudes recorded with surface electrodes placed on the target muscle...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28188756/therapeutic-effect-and-mechanism-of-electrical-stimulation-in-female-stress-urinary-incontinence
#15
Jie Min, Bingshu Li, Cheng Liu, Shasha Hong, Jianming Tang, Ming Hu, Yaodan Liu, Suting Li, Li Hong
OBJECTIVE: To investigate the therapeutic effect and underlying molecular mechanism of electrical stimulation (ES) in a murine SUI model. MATERIALS AND METHODS: Sixty female C57BL/6 mice were divided into four groups: CON group, no intervention; VD group, vaginal distension (VD) with an 8-mm dilator for 1 h; VD+ES 20 group, 20 Hz ES for 0.5 h for 7 days after VD; VD+ES 50 group, 50 Hz ES for 7 days after VD. For functional studies, assessments of urodynamics and sneezing test were performed; then, anterior vaginal wall specimens were collected...
February 7, 2017: Urology
https://www.readbyqxmd.com/read/28188627/dose-dependency-of-transcranial-direct-current-stimulation-implications-for-neuroplasticity-induction-in-health-and-disease
#16
Mitchell R Goldsworthy, Brenton Hordacre
There has been a rapid growth in the use of non-invasive brain stimulation to induce neuroplasticity and modulate human brain function over the past decade. An example of this is transcranial direct current stimulation (tDCS), which involves the application of weak electrical currents between at least two electrodes placed over the scalp. When applied to the primary motor cortex (M1), tDCS can induce lasting polarity-dependent changes in excitability, with facilitation following anodal stimulation and suppression following cathodal...
February 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28188470/modeling-the-effect-of-tilting-passive-leg-exercise-and-functional-electrical-stimulation-on-the-human-cardiovascular-system
#17
Amirehsan Sarabadani Tafreshi, Jan Okle, Verena Klamroth-Marganska, Robert Riener
Long periods of bed rest negatively affect the human body organs, notably the cardiovascular system. To avert these negative effects and promote functional recovery in patients dealing with prolonged bed rest, the goal is to mobilize them as early as possible while controlling and stabilizing their cardiovascular system. A robotic tilt table allows early mobilization by modulating body inclination, automated passive leg exercise, and the intensity of functional electrical stimulation applied to leg muscles (inputs)...
February 10, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28187396/methyl-orvinol-dual-activity-opioid-receptor-ligand-inhibits-gastrointestinal-transit-and-alleviates-abdominal-pain-in-the-mouse-models-mimicking-diarrhea-predominant-irritable-bowel-syndrome
#18
Marta Zielińska, Agata Jarmuż, Andrzej Wasilewski, Gerta Cami-Kobeci, Stephen Husbands, Jakub Fichna
BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional disorder of the gastrointestinal (GI) tract. The major IBS-D symptoms include diarrhea, abdominal pain and discomfort. High density of opioid receptors (ORs) in the GI tract and their participation in the maintenance of GI homeostasis make ORs ligands an attractive option for developing new anti-IBS-D treatments. The aim of this study was to characterize the effect of methyl-orvinol on the GI motility and secretion and in mouse models mimicking symptoms of IBS-D...
December 5, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28187250/phase-imaging-with-multiple-phase-cycled-balanced-steady-state-free-precession-at-9-4%C3%A2-t
#19
Jae-Woong Kim, Seong-Gi Kim, Sung-Hong Park
While phase imaging with a gradient echo (GRE) sequence is popular, phase imaging with balanced steady-state free precession (bSSFP) has been underexplored. The purpose of this study was to investigate anatomical and functional phase imaging with multiple phase-cycled bSSFP, in expectation of increasing spatial coverage of steep phase-change regions of bSSFP. Eight different dynamic 2D pass-band bSSFP studies at four phase-cycling (PC) angles and two TE /TR values were performed on rat brains at 9.4 T with electrical forepaw stimulation, in comparison with dynamic 2D GRE...
February 10, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28185910/ultrasoft-microwire-neural-electrodes-improve-chronic-tissue-integration
#20
Zhanhong Jeff Du, Christi L Kolarcik, Takashi D Y Kozai, Silvia D Luebben, Shawn A Sapp, Xin Sally Zheng, James A Nabity, X Tracy Cui
: Chronically implanted neural multi-electrode arrays (MEA) are an essential technology for recording electrical signals from neurons and/or modulating neural activity through stimulation. However, current MEAs, regardless of the type, elicit an inflammatory response that ultimately leads to device failure. Traditionally, rigid materials like tungsten and silicon have been employed to interface with the relatively soft neural tissue. The large stiffness mismatch is thought to exacerbate the inflammatory response...
February 6, 2017: Acta Biomaterialia
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